-- dump date 20120504_134220 -- class Genbank::misc_feature -- table misc_feature_note -- id note 315750000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 315750000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 315750000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750000004 Walker A motif; other site 315750000005 ATP binding site [chemical binding]; other site 315750000006 Walker B motif; other site 315750000007 arginine finger; other site 315750000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 315750000009 DnaA box-binding interface [nucleotide binding]; other site 315750000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 315750000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 315750000012 putative DNA binding surface [nucleotide binding]; other site 315750000013 dimer interface [polypeptide binding]; other site 315750000014 beta-clamp/clamp loader binding surface; other site 315750000015 beta-clamp/translesion DNA polymerase binding surface; other site 315750000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 315750000017 recombination protein F; Reviewed; Region: recF; PRK00064 315750000018 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 315750000019 Walker A/P-loop; other site 315750000020 ATP binding site [chemical binding]; other site 315750000021 Q-loop/lid; other site 315750000022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750000023 ABC transporter signature motif; other site 315750000024 Walker B; other site 315750000025 D-loop; other site 315750000026 H-loop/switch region; other site 315750000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 315750000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750000029 ATP binding site [chemical binding]; other site 315750000030 Mg2+ binding site [ion binding]; other site 315750000031 G-X-G motif; other site 315750000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 315750000033 anchoring element; other site 315750000034 dimer interface [polypeptide binding]; other site 315750000035 ATP binding site [chemical binding]; other site 315750000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 315750000037 active site 315750000038 putative metal-binding site [ion binding]; other site 315750000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 315750000040 DNA gyrase subunit A; Validated; Region: PRK05560 315750000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 315750000042 CAP-like domain; other site 315750000043 active site 315750000044 primary dimer interface [polypeptide binding]; other site 315750000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315750000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315750000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315750000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315750000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315750000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315750000051 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 315750000052 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 315750000053 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 315750000054 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 315750000055 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 315750000056 homodimer interface [polypeptide binding]; other site 315750000057 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750000058 catalytic residue [active] 315750000059 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 315750000060 thymidylate kinase; Validated; Region: tmk; PRK00698 315750000061 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 315750000062 TMP-binding site; other site 315750000063 ATP-binding site [chemical binding]; other site 315750000064 Nitrogen regulatory protein P-II; Region: P-II; cl00412 315750000065 Protein of unknown function (DUF327); Region: DUF327; cl00753 315750000066 DNA polymerase III subunit delta'; Validated; Region: PRK08058 315750000067 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750000068 PSP1 C-terminal conserved region; Region: PSP1; cl00770 315750000069 TSC-22/dip/bun family; Region: TSC22; cl01853 315750000070 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 315750000071 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750000072 S-adenosylmethionine binding site [chemical binding]; other site 315750000073 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 315750000074 GIY-YIG motif/motif A; other site 315750000075 putative active site [active] 315750000076 putative metal binding site [ion binding]; other site 315750000077 Predicted methyltransferases [General function prediction only]; Region: COG0313 315750000078 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 315750000079 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 315750000080 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 315750000081 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 315750000082 active site 315750000083 HIGH motif; other site 315750000084 KMSKS motif; other site 315750000085 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 315750000086 tRNA binding surface [nucleotide binding]; other site 315750000087 anticodon binding site; other site 315750000088 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 315750000089 putative tRNA-binding site [nucleotide binding]; other site 315750000090 dimer interface [polypeptide binding]; other site 315750000091 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 315750000092 active site 315750000093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 315750000094 Domain of unknown function (DUF348); Region: DUF348; pfam03990 315750000095 Domain of unknown function (DUF348); Region: DUF348; pfam03990 315750000096 Domain of unknown function (DUF348); Region: DUF348; pfam03990 315750000097 G5 domain; Region: G5; pfam07501 315750000098 3D domain; Region: 3D; cl01439 315750000099 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 315750000100 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 315750000101 putative active site [active] 315750000102 putative metal binding site [ion binding]; other site 315750000103 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 315750000104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750000105 S-adenosylmethionine binding site [chemical binding]; other site 315750000106 YabG peptidase U57; Region: Peptidase_U57; cl05250 315750000107 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 315750000108 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 315750000109 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 315750000110 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 315750000111 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 315750000112 pur operon repressor; Provisional; Region: PRK09213 315750000113 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 315750000114 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315750000115 active site 315750000116 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 315750000117 homotrimer interaction site [polypeptide binding]; other site 315750000118 putative active site [active] 315750000119 SpoVG; Region: SpoVG; cl00915 315750000120 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 315750000121 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 315750000122 Substrate binding site; other site 315750000123 Mg++ binding site; other site 315750000124 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 315750000125 active site 315750000126 substrate binding site [chemical binding]; other site 315750000127 CoA binding site [chemical binding]; other site 315750000128 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 315750000129 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 315750000130 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315750000131 active site 315750000132 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 315750000133 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 315750000134 5S rRNA interface [nucleotide binding]; other site 315750000135 CTC domain interface [polypeptide binding]; other site 315750000136 L16 interface [polypeptide binding]; other site 315750000137 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 315750000138 putative active site [active] 315750000139 catalytic residue [active] 315750000140 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 315750000141 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 315750000142 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 315750000143 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315750000144 ATP binding site [chemical binding]; other site 315750000145 putative Mg++ binding site [ion binding]; other site 315750000146 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315750000147 nucleotide binding region [chemical binding]; other site 315750000148 ATP-binding site [chemical binding]; other site 315750000149 TRCF domain; Region: TRCF; cl04088 315750000150 stage V sporulation protein T; Region: spore_V_T; TIGR02851 315750000151 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 315750000152 GAF domain; Region: GAF; cl15785 315750000153 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 315750000154 MatE; Region: MatE; cl10513 315750000155 MatE; Region: MatE; cl10513 315750000156 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 315750000157 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 315750000158 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 315750000159 homodimer interface [polypeptide binding]; other site 315750000160 metal binding site [ion binding]; metal-binding site 315750000161 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs'; Region: NTP-PPase_MazG_Cterm; cd11529 315750000162 homodimer interface [polypeptide binding]; other site 315750000163 active site 315750000164 putative chemical substrate binding site [chemical binding]; other site 315750000165 metal binding site [ion binding]; metal-binding site 315750000166 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315750000167 RNA binding surface [nucleotide binding]; other site 315750000168 YabP family; Region: YabP; cl06766 315750000169 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 315750000170 Septum formation initiator; Region: DivIC; cl11433 315750000171 hypothetical protein; Provisional; Region: PRK08582 315750000172 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 315750000173 RNA binding site [nucleotide binding]; other site 315750000174 stage II sporulation protein E; Region: spore_II_E; TIGR02865 315750000175 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 315750000176 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 315750000177 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 315750000178 metal ion-dependent adhesion site (MIDAS); other site 315750000179 Catalytic domain of Protein Kinases; Region: PKc; cd00180 315750000180 active site 315750000181 ATP binding site [chemical binding]; other site 315750000182 substrate binding site [chemical binding]; other site 315750000183 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 315750000184 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 315750000185 Ligand Binding Site [chemical binding]; other site 315750000186 B3/4 domain; Region: B3_4; cl11458 315750000187 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315750000188 active site 315750000189 FtsH Extracellular; Region: FtsH_ext; pfam06480 315750000190 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 315750000191 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750000192 Walker A motif; other site 315750000193 ATP binding site [chemical binding]; other site 315750000194 Walker B motif; other site 315750000195 arginine finger; other site 315750000196 Peptidase family M41; Region: Peptidase_M41; pfam01434 315750000197 Type III pantothenate kinase; Region: Pan_kinase; cl09130 315750000198 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 315750000199 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 315750000200 dimerization interface [polypeptide binding]; other site 315750000201 domain crossover interface; other site 315750000202 redox-dependent activation switch; other site 315750000203 SurA N-terminal domain; Region: SurA_N_3; cl07813 315750000204 PPIC-type PPIASE domain; Region: Rotamase; cl08278 315750000205 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 315750000206 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 315750000207 dimer interface [polypeptide binding]; other site 315750000208 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750000209 catalytic residue [active] 315750000210 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 315750000211 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 315750000212 chorismate binding enzyme; Region: Chorismate_bind; cl10555 315750000213 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 315750000214 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 315750000215 glutamine binding [chemical binding]; other site 315750000216 catalytic triad [active] 315750000217 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 315750000218 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750000219 catalytic residue [active] 315750000220 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 315750000221 dihydropteroate synthase; Region: DHPS; TIGR01496 315750000222 substrate binding pocket [chemical binding]; other site 315750000223 dimer interface [polypeptide binding]; other site 315750000224 inhibitor binding site; inhibition site 315750000225 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 315750000226 homooctamer interface [polypeptide binding]; other site 315750000227 active site 315750000228 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 315750000229 catalytic center binding site [active] 315750000230 ATP binding site [chemical binding]; other site 315750000231 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315750000232 non-specific DNA binding site [nucleotide binding]; other site 315750000233 salt bridge; other site 315750000234 sequence-specific DNA binding site [nucleotide binding]; other site 315750000235 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 315750000236 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 315750000237 FMN binding site [chemical binding]; other site 315750000238 active site 315750000239 catalytic residues [active] 315750000240 substrate binding site [chemical binding]; other site 315750000241 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 315750000242 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 315750000243 dimer interface [polypeptide binding]; other site 315750000244 putative anticodon binding site; other site 315750000245 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 315750000246 motif 1; other site 315750000247 active site 315750000248 motif 2; other site 315750000249 motif 3; other site 315750000250 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 315750000251 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 315750000252 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 315750000253 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 315750000254 ADP binding site [chemical binding]; other site 315750000255 phosphagen binding site; other site 315750000256 substrate specificity loop; other site 315750000257 Clp protease ATP binding subunit; Region: clpC; CHL00095 315750000258 Clp amino terminal domain; Region: Clp_N; pfam02861 315750000259 Clp amino terminal domain; Region: Clp_N; pfam02861 315750000260 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750000261 Walker A motif; other site 315750000262 ATP binding site [chemical binding]; other site 315750000263 Walker B motif; other site 315750000264 arginine finger; other site 315750000265 UvrB/uvrC motif; Region: UVR; pfam02151 315750000266 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750000267 Walker A motif; other site 315750000268 ATP binding site [chemical binding]; other site 315750000269 Walker B motif; other site 315750000270 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 315750000271 DNA repair protein RadA; Provisional; Region: PRK11823 315750000272 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 315750000273 Walker A motif/ATP binding site; other site 315750000274 ATP binding site [chemical binding]; other site 315750000275 Walker B motif; other site 315750000276 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 315750000277 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 315750000278 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 315750000279 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 315750000280 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 315750000281 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 315750000282 putative active site [active] 315750000283 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 315750000284 substrate binding site; other site 315750000285 dimer interface; other site 315750000286 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 315750000287 homotrimer interaction site [polypeptide binding]; other site 315750000288 zinc binding site [ion binding]; other site 315750000289 CDP-binding sites; other site 315750000290 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 315750000291 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 315750000292 HIGH motif; other site 315750000293 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 315750000294 active site 315750000295 KMSKS motif; other site 315750000296 serine O-acetyltransferase; Region: cysE; TIGR01172 315750000297 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 315750000298 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 315750000299 trimer interface [polypeptide binding]; other site 315750000300 active site 315750000301 substrate binding site [chemical binding]; other site 315750000302 CoA binding site [chemical binding]; other site 315750000303 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 315750000304 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 315750000305 active site 315750000306 HIGH motif; other site 315750000307 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 315750000308 KMSKS motif; other site 315750000309 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 315750000310 tRNA binding surface [nucleotide binding]; other site 315750000311 anticodon binding site; other site 315750000312 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 315750000313 active site 315750000314 metal binding site [ion binding]; metal-binding site 315750000315 dimerization interface [polypeptide binding]; other site 315750000316 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 315750000317 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 315750000318 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 315750000319 YacP-like NYN domain; Region: NYN_YacP; cl01491 315750000320 RNA polymerase factor sigma-70; Validated; Region: PRK08295 315750000321 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315750000322 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 315750000323 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 315750000324 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 315750000325 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 315750000326 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 315750000327 putative homodimer interface [polypeptide binding]; other site 315750000328 KOW motif; Region: KOW; cl00354 315750000329 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 315750000330 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 315750000331 putative thiostrepton binding site; other site 315750000332 23S rRNA interface [nucleotide binding]; other site 315750000333 L7/L12 interface [polypeptide binding]; other site 315750000334 L25 interface [polypeptide binding]; other site 315750000335 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 315750000336 mRNA/rRNA interface [nucleotide binding]; other site 315750000337 BPUM_nc0001; ribosomal protein L10 leader 315750000338 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 315750000339 23S rRNA interface [nucleotide binding]; other site 315750000340 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 315750000341 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 315750000342 core dimer interface [polypeptide binding]; other site 315750000343 peripheral dimer interface [polypeptide binding]; other site 315750000344 L10 interface [polypeptide binding]; other site 315750000345 L11 interface [polypeptide binding]; other site 315750000346 putative EF-Tu interaction site [polypeptide binding]; other site 315750000347 putative EF-G interaction site [polypeptide binding]; other site 315750000348 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 315750000349 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750000350 DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085 315750000351 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 315750000352 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 315750000353 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 315750000354 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 315750000355 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 315750000356 RPB12 interaction site [polypeptide binding]; other site 315750000357 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 315750000358 RPB10 interaction site [polypeptide binding]; other site 315750000359 RPB1 interaction site [polypeptide binding]; other site 315750000360 RPB11 interaction site [polypeptide binding]; other site 315750000361 RPB3 interaction site [polypeptide binding]; other site 315750000362 RPB12 interaction site [polypeptide binding]; other site 315750000363 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 315750000364 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 315750000365 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 315750000366 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 315750000367 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 315750000368 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 315750000369 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 315750000370 G-loop; other site 315750000371 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 315750000372 DNA binding site [nucleotide binding] 315750000373 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 315750000374 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 315750000375 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 315750000376 S17 interaction site [polypeptide binding]; other site 315750000377 S8 interaction site; other site 315750000378 16S rRNA interaction site [nucleotide binding]; other site 315750000379 streptomycin interaction site [chemical binding]; other site 315750000380 23S rRNA interaction site [nucleotide binding]; other site 315750000381 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 315750000382 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 315750000383 elongation factor G; Reviewed; Region: PRK00007 315750000384 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 315750000385 G1 box; other site 315750000386 putative GEF interaction site [polypeptide binding]; other site 315750000387 GTP/Mg2+ binding site [chemical binding]; other site 315750000388 Switch I region; other site 315750000389 G2 box; other site 315750000390 G3 box; other site 315750000391 Switch II region; other site 315750000392 G4 box; other site 315750000393 G5 box; other site 315750000394 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 315750000395 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 315750000396 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 315750000397 elongation factor Tu; Reviewed; Region: PRK00049 315750000398 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 315750000399 G1 box; other site 315750000400 GEF interaction site [polypeptide binding]; other site 315750000401 GTP/Mg2+ binding site [chemical binding]; other site 315750000402 Switch I region; other site 315750000403 G2 box; other site 315750000404 G3 box; other site 315750000405 Switch II region; other site 315750000406 G4 box; other site 315750000407 G5 box; other site 315750000408 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 315750000409 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 315750000410 Antibiotic Binding Site [chemical binding]; other site 315750000411 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315750000412 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 315750000413 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 315750000414 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 315750000415 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 315750000416 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 315750000417 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 315750000418 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 315750000419 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 315750000420 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 315750000421 putative translocon binding site; other site 315750000422 protein-rRNA interface [nucleotide binding]; other site 315750000423 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 315750000424 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 315750000425 G-X-X-G motif; other site 315750000426 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 315750000427 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 315750000428 23S rRNA interface [nucleotide binding]; other site 315750000429 5S rRNA interface [nucleotide binding]; other site 315750000430 putative antibiotic binding site [chemical binding]; other site 315750000431 L25 interface [polypeptide binding]; other site 315750000432 L27 interface [polypeptide binding]; other site 315750000433 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 315750000434 23S rRNA interface [nucleotide binding]; other site 315750000435 putative translocon interaction site; other site 315750000436 signal recognition particle (SRP54) interaction site; other site 315750000437 L23 interface [polypeptide binding]; other site 315750000438 trigger factor interaction site; other site 315750000439 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 315750000440 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 315750000441 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 315750000442 KOW motif; Region: KOW; cl00354 315750000443 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 315750000444 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 315750000445 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 315750000446 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 315750000447 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 315750000448 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 315750000449 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 315750000450 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 315750000451 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 315750000452 5S rRNA interface [nucleotide binding]; other site 315750000453 L27 interface [polypeptide binding]; other site 315750000454 23S rRNA interface [nucleotide binding]; other site 315750000455 L5 interface [polypeptide binding]; other site 315750000456 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 315750000457 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 315750000458 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 315750000459 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 315750000460 23S rRNA binding site [nucleotide binding]; other site 315750000461 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 315750000462 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 315750000463 SecY translocase; Region: SecY; pfam00344 315750000464 adenylate kinase; Reviewed; Region: adk; PRK00279 315750000465 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 315750000466 AMP-binding site [chemical binding]; other site 315750000467 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 315750000468 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 315750000469 active site 315750000470 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 315750000471 rRNA binding site [nucleotide binding]; other site 315750000472 predicted 30S ribosome binding site; other site 315750000473 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 315750000474 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 315750000475 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 315750000476 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 315750000477 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 315750000478 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 315750000479 alphaNTD homodimer interface [polypeptide binding]; other site 315750000480 alphaNTD - beta interaction site [polypeptide binding]; other site 315750000481 alphaNTD - beta' interaction site [polypeptide binding]; other site 315750000482 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 315750000483 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 315750000484 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 315750000485 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 315750000486 Walker A/P-loop; other site 315750000487 ATP binding site [chemical binding]; other site 315750000488 Q-loop/lid; other site 315750000489 ABC transporter signature motif; other site 315750000490 Walker B; other site 315750000491 D-loop; other site 315750000492 H-loop/switch region; other site 315750000493 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 315750000494 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 315750000495 Walker A/P-loop; other site 315750000496 ATP binding site [chemical binding]; other site 315750000497 Q-loop/lid; other site 315750000498 ABC transporter signature motif; other site 315750000499 Walker B; other site 315750000500 D-loop; other site 315750000501 H-loop/switch region; other site 315750000502 Cobalt transport protein; Region: CbiQ; cl00463 315750000503 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 315750000504 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 315750000505 dimerization interface 3.5A [polypeptide binding]; other site 315750000506 active site 315750000507 BPUM_nc0002; ribosomal protein L13 leader 315750000508 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 315750000509 23S rRNA interface [nucleotide binding]; other site 315750000510 L3 interface [polypeptide binding]; other site 315750000511 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 315750000512 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315750000513 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315750000514 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 315750000515 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 315750000516 active site 315750000517 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 315750000518 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750000519 Coenzyme A binding pocket [chemical binding]; other site 315750000520 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315750000521 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 315750000522 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 315750000523 active site 315750000524 metal binding site [ion binding]; metal-binding site 315750000525 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 315750000526 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 315750000527 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 315750000528 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 315750000529 flagellin; Provisional; Region: PRK12804 315750000530 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 315750000531 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 315750000532 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 315750000533 Sulfate transporter family; Region: Sulfate_transp; cl15842 315750000534 Sulfate transporter family; Region: Sulfate_transp; cl15842 315750000535 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 315750000536 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 315750000537 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 315750000538 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 315750000539 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 315750000540 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 315750000541 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315750000542 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 315750000543 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 315750000544 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 315750000545 active site turn [active] 315750000546 phosphorylation site [posttranslational modification] 315750000547 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 315750000548 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 315750000549 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 315750000550 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 315750000551 putative active site [active] 315750000552 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 315750000553 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 315750000554 putative active site [active] 315750000555 Arginase family; Region: Arginase; cl00306 315750000556 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 315750000557 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315750000558 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315750000559 DNA binding residues [nucleotide binding] 315750000560 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 315750000561 Putative zinc-finger; Region: zf-HC2; cl15806 315750000562 TIGR00159 family protein; Region: TIGR00159 315750000563 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 315750000564 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 315750000565 YbbR-like protein; Region: YbbR; pfam07949 315750000566 YbbR-like protein; Region: YbbR; pfam07949 315750000567 YbbR-like protein; Region: YbbR; pfam07949 315750000568 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 315750000569 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 315750000570 active site 315750000571 substrate binding site [chemical binding]; other site 315750000572 metal binding site [ion binding]; metal-binding site 315750000573 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 315750000574 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 315750000575 glutaminase active site [active] 315750000576 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 315750000577 dimer interface [polypeptide binding]; other site 315750000578 active site 315750000579 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 315750000580 dimer interface [polypeptide binding]; other site 315750000581 active site 315750000582 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; cl02047 315750000583 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 315750000584 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315750000585 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 315750000586 Walker A/P-loop; other site 315750000587 ATP binding site [chemical binding]; other site 315750000588 Q-loop/lid; other site 315750000589 ABC transporter signature motif; other site 315750000590 Walker B; other site 315750000591 D-loop; other site 315750000592 H-loop/switch region; other site 315750000593 ABC-2 type transporter; Region: ABC2_membrane; cl11417 315750000594 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 315750000595 homotrimer interaction site [polypeptide binding]; other site 315750000596 putative active site [active] 315750000597 Predicted membrane protein [Function unknown]; Region: COG2311 315750000598 Protein of unknown function (DUF418); Region: DUF418; cl12135 315750000599 Predicted transcriptional regulators [Transcription]; Region: COG1725 315750000600 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315750000601 DNA-binding site [nucleotide binding]; DNA binding site 315750000602 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315750000603 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 315750000604 Walker A/P-loop; other site 315750000605 ATP binding site [chemical binding]; other site 315750000606 Q-loop/lid; other site 315750000607 ABC transporter signature motif; other site 315750000608 Walker B; other site 315750000609 D-loop; other site 315750000610 H-loop/switch region; other site 315750000611 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 315750000612 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315750000613 non-specific DNA binding site [nucleotide binding]; other site 315750000614 salt bridge; other site 315750000615 sequence-specific DNA binding site [nucleotide binding]; other site 315750000616 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315750000617 putative transport protein YifK; Provisional; Region: PRK10746 315750000618 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 315750000619 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 315750000620 active site 315750000621 catalytic site [active] 315750000622 metal binding site [ion binding]; metal-binding site 315750000623 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 315750000624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750000625 putative substrate translocation pore; other site 315750000626 SurA N-terminal domain; Region: SurA_N_3; cl07813 315750000627 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 315750000628 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 315750000629 catalytic residues [active] 315750000630 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 315750000631 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 315750000632 putative homodimer interface [polypeptide binding]; other site 315750000633 putative homotetramer interface [polypeptide binding]; other site 315750000634 putative metal binding site [ion binding]; other site 315750000635 putative homodimer-homodimer interface [polypeptide binding]; other site 315750000636 putative allosteric switch controlling residues; other site 315750000637 DsrE/DsrF-like family; Region: DrsE; cl00672 315750000638 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 315750000639 active site residue [active] 315750000640 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 315750000641 CPxP motif; other site 315750000642 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 315750000643 active site residue [active] 315750000644 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 315750000645 active site residue [active] 315750000646 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315750000647 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 315750000648 CPxP motif; other site 315750000649 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 315750000650 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 315750000651 prolyl-tRNA synthetase; Provisional; Region: PRK08661 315750000652 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_arch_euk; cd00778 315750000653 dimer interface [polypeptide binding]; other site 315750000654 motif 1; other site 315750000655 active site 315750000656 motif 2; other site 315750000657 motif 3; other site 315750000658 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 315750000659 anticodon binding site; other site 315750000660 zinc-binding site [ion binding]; other site 315750000661 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 315750000662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750000663 putative substrate translocation pore; other site 315750000664 Predicted acetyltransferase [General function prediction only]; Region: COG3393 315750000665 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315750000666 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315750000667 Helix-turn-helix domains; Region: HTH; cl00088 315750000668 Protein of unknown function (DUF523); Region: DUF523; cl00733 315750000669 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 315750000670 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 315750000671 active site 315750000672 catalytic tetrad [active] 315750000673 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 315750000674 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 315750000675 putative active site [active] 315750000676 metal binding site [ion binding]; metal-binding site 315750000677 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 315750000678 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 315750000679 active site residue [active] 315750000680 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 315750000681 amino acid transporter; Region: 2A0306; TIGR00909 315750000682 Spore germination protein; Region: Spore_permease; cl15802 315750000683 transcriptional antiterminator BglG; Provisional; Region: PRK09772 315750000684 CAT RNA binding domain; Region: CAT_RBD; cl03904 315750000685 PRD domain; Region: PRD; cl15445 315750000686 PRD domain; Region: PRD; cl15445 315750000687 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 315750000688 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 315750000689 active site turn [active] 315750000690 phosphorylation site [posttranslational modification] 315750000691 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 315750000692 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 315750000693 HPr interaction site; other site 315750000694 glycerol kinase (GK) interaction site [polypeptide binding]; other site 315750000695 active site 315750000696 phosphorylation site [posttranslational modification] 315750000697 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 315750000698 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 315750000699 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 315750000700 Helix-turn-helix domains; Region: HTH; cl00088 315750000701 Helix-turn-helix domains; Region: HTH; cl00088 315750000702 PRD domain; Region: PRD; cl15445 315750000703 PRD domain; Region: PRD; cl15445 315750000704 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 315750000705 active site 315750000706 P-loop; other site 315750000707 phosphorylation site [posttranslational modification] 315750000708 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 315750000709 active site 315750000710 phosphorylation site [posttranslational modification] 315750000711 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 315750000712 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 315750000713 alpha-mannosidase; Provisional; Region: PRK09819 315750000714 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 315750000715 active site 315750000716 metal binding site [ion binding]; metal-binding site 315750000717 catalytic site [active] 315750000718 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 315750000719 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 315750000720 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 315750000721 active site 315750000722 P-loop; other site 315750000723 phosphorylation site [posttranslational modification] 315750000724 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 315750000725 active site 315750000726 phosphorylation site [posttranslational modification] 315750000727 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 315750000728 active site 315750000729 catalytic triad [active] 315750000730 MG2 domain; Region: A2M_N; pfam01835 315750000731 S-methylmethionine transporter; Provisional; Region: PRK11387 315750000732 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 315750000733 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 315750000734 Helix-turn-helix domains; Region: HTH; cl00088 315750000735 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 315750000736 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 315750000737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750000738 putative substrate translocation pore; other site 315750000739 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 315750000740 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750000741 Coenzyme A binding pocket [chemical binding]; other site 315750000742 Protein of unknown function (DUF402); Region: DUF402; cl00979 315750000743 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 315750000744 active site 315750000745 catalytic residues [active] 315750000746 amidase; Provisional; Region: PRK06529 315750000747 Amidase; Region: Amidase; cl11426 315750000748 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750000749 Helix-turn-helix domains; Region: HTH; cl00088 315750000750 Cupin domain; Region: Cupin_2; cl09118 315750000751 Cupin domain; Region: Cupin_2; cl09118 315750000752 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 315750000753 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 315750000754 NAD binding site [chemical binding]; other site 315750000755 catalytic Zn binding site [ion binding]; other site 315750000756 structural Zn binding site [ion binding]; other site 315750000757 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315750000758 Helix-turn-helix domains; Region: HTH; cl00088 315750000759 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 315750000760 AMP-binding enzyme; Region: AMP-binding; cl15778 315750000761 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315750000762 amino acid transporter; Region: 2A0306; TIGR00909 315750000763 Spore germination protein; Region: Spore_permease; cl15802 315750000764 Spore germination protein; Region: Spore_permease; cl15802 315750000765 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 315750000766 dimer interface [polypeptide binding]; other site 315750000767 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315750000768 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315750000769 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315750000770 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 315750000771 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 315750000772 Glutaminase; Region: Glutaminase; cl00907 315750000773 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315750000774 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750000775 ATP binding site [chemical binding]; other site 315750000776 Mg2+ binding site [ion binding]; other site 315750000777 G-X-G motif; other site 315750000778 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750000779 Response regulator receiver domain; Region: Response_reg; pfam00072 315750000780 active site 315750000781 phosphorylation site [posttranslational modification] 315750000782 intermolecular recognition site; other site 315750000783 dimerization interface [polypeptide binding]; other site 315750000784 YcbB domain; Region: YcbB; pfam08664 315750000785 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 315750000786 SEC-C motif; Region: SEC-C; pfam02810 315750000787 Helix-turn-helix domains; Region: HTH; cl00088 315750000788 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 315750000789 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 315750000790 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 315750000791 active site 315750000792 catalytic tetrad [active] 315750000793 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 315750000794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750000795 ATP binding site [chemical binding]; other site 315750000796 Mg2+ binding site [ion binding]; other site 315750000797 G-X-G motif; other site 315750000798 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 315750000799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750000800 active site 315750000801 phosphorylation site [posttranslational modification] 315750000802 intermolecular recognition site; other site 315750000803 dimerization interface [polypeptide binding]; other site 315750000804 LytTr DNA-binding domain; Region: LytTR; cl04498 315750000805 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 315750000806 NatA is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled proton or K+ uptake. NatB possess six putative membrane spanning regions at its...; Region: ABC_NatA_sodium_exporter; cd03266 315750000807 Walker A/P-loop; other site 315750000808 ATP binding site [chemical binding]; other site 315750000809 Q-loop/lid; other site 315750000810 ABC transporter signature motif; other site 315750000811 Walker B; other site 315750000812 D-loop; other site 315750000813 H-loop/switch region; other site 315750000814 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 315750000815 ABC-2 type transporter; Region: ABC2_membrane; cl11417 315750000816 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 315750000817 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 315750000818 glucose-1-dehydrogenase; Provisional; Region: PRK08936 315750000819 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 315750000820 NAD binding site [chemical binding]; other site 315750000821 homodimer interface [polypeptide binding]; other site 315750000822 active site 315750000823 OpgC protein; Region: OpgC_C; cl00792 315750000824 Acyltransferase family; Region: Acyl_transf_3; pfam01757 315750000825 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 315750000826 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 315750000827 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 315750000828 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 315750000829 putative metal binding site [ion binding]; other site 315750000830 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 315750000831 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 315750000832 putative metal binding site [ion binding]; other site 315750000833 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 315750000834 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 315750000835 putative metal binding site [ion binding]; other site 315750000836 Integral membrane protein TerC family; Region: TerC; cl10468 315750000837 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 315750000838 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 315750000839 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 315750000840 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 315750000841 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 315750000842 active site 315750000843 motif I; other site 315750000844 motif II; other site 315750000845 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 315750000846 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 315750000847 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 315750000848 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 315750000849 Walker A/P-loop; other site 315750000850 ATP binding site [chemical binding]; other site 315750000851 Q-loop/lid; other site 315750000852 ABC transporter signature motif; other site 315750000853 Walker B; other site 315750000854 D-loop; other site 315750000855 H-loop/switch region; other site 315750000856 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 315750000857 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750000858 dimer interface [polypeptide binding]; other site 315750000859 conserved gate region; other site 315750000860 putative PBP binding loops; other site 315750000861 ABC-ATPase subunit interface; other site 315750000862 NMT1-like family; Region: NMT1_2; cl15260 315750000863 NMT1-like family; Region: NMT1_2; cl15260 315750000864 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315750000865 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315750000866 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 315750000867 classical (c) SDRs; Region: SDR_c; cd05233 315750000868 NAD(P) binding site [chemical binding]; other site 315750000869 active site 315750000870 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 315750000871 amidohydrolase; Region: amidohydrolases; TIGR01891 315750000872 metal binding site [ion binding]; metal-binding site 315750000873 putative dimer interface [polypeptide binding]; other site 315750000874 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 315750000875 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 315750000876 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 315750000877 tetramer (dimer of dimers) interface [polypeptide binding]; other site 315750000878 NAD binding site [chemical binding]; other site 315750000879 dimer interface [polypeptide binding]; other site 315750000880 substrate binding site [chemical binding]; other site 315750000881 glycolate transporter; Provisional; Region: PRK09695 315750000882 L-lactate permease; Region: Lactate_perm; cl00701 315750000883 Transcriptional regulators [Transcription]; Region: PurR; COG1609 315750000884 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315750000885 DNA binding site [nucleotide binding] 315750000886 domain linker motif; other site 315750000887 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 315750000888 putative dimerization interface [polypeptide binding]; other site 315750000889 putative ligand binding site [chemical binding]; other site 315750000890 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 315750000891 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 315750000892 inhibitor-cofactor binding pocket; inhibition site 315750000893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750000894 catalytic residue [active] 315750000895 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 315750000896 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 315750000897 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750000898 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 315750000899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750000900 putative substrate translocation pore; other site 315750000901 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315750000902 LysE type translocator; Region: LysE; cl00565 315750000903 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 315750000904 Spore germination protein; Region: Spore_permease; cl15802 315750000905 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 315750000906 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 315750000907 NAD+ synthetase; Region: nadE; TIGR00552 315750000908 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 315750000909 homodimer interface [polypeptide binding]; other site 315750000910 NAD binding pocket [chemical binding]; other site 315750000911 ATP binding pocket [chemical binding]; other site 315750000912 Mg binding site [ion binding]; other site 315750000913 active-site loop [active] 315750000914 shikimate kinase; Reviewed; Region: aroK; PRK00131 315750000915 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 315750000916 ADP binding site [chemical binding]; other site 315750000917 magnesium binding site [ion binding]; other site 315750000918 putative shikimate binding site; other site 315750000919 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 315750000920 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 315750000921 inhibitor site; inhibition site 315750000922 active site 315750000923 dimer interface [polypeptide binding]; other site 315750000924 catalytic residue [active] 315750000925 Transcriptional regulators [Transcription]; Region: PurR; COG1609 315750000926 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315750000927 DNA binding site [nucleotide binding] 315750000928 domain linker motif; other site 315750000929 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 315750000930 dimerization interface [polypeptide binding]; other site 315750000931 ligand binding site [chemical binding]; other site 315750000932 benzoate transport; Region: 2A0115; TIGR00895 315750000933 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750000934 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750000935 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315750000936 Helix-turn-helix domains; Region: HTH; cl00088 315750000937 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315750000938 dimerization interface [polypeptide binding]; other site 315750000939 Predicted amidohydrolase [General function prediction only]; Region: COG0388 315750000940 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 315750000941 putative active site [active] 315750000942 catalytic triad [active] 315750000943 putative dimer interface [polypeptide binding]; other site 315750000944 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 315750000945 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 315750000946 Proline dehydrogenase; Region: Pro_dh; cl03282 315750000947 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 315750000948 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 315750000949 Glutamate binding site [chemical binding]; other site 315750000950 homodimer interface [polypeptide binding]; other site 315750000951 NAD binding site [chemical binding]; other site 315750000952 catalytic residues [active] 315750000953 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 315750000954 Helix-turn-helix domains; Region: HTH; cl00088 315750000955 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 315750000956 arsenical pump membrane protein; Provisional; Region: PRK15445 315750000957 transmembrane helices; other site 315750000958 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 315750000959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750000960 dimer interface [polypeptide binding]; other site 315750000961 conserved gate region; other site 315750000962 putative PBP binding loops; other site 315750000963 ABC-ATPase subunit interface; other site 315750000964 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 315750000965 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 315750000966 substrate binding pocket [chemical binding]; other site 315750000967 membrane-bound complex binding site; other site 315750000968 hinge residues; other site 315750000969 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 315750000970 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315750000971 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 315750000972 Helix-turn-helix domains; Region: HTH; cl00088 315750000973 AsnC family; Region: AsnC_trans_reg; pfam01037 315750000974 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 315750000975 Competence protein J (ComJ); Region: ComJ; pfam11033 315750000976 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315750000977 dimerization interface [polypeptide binding]; other site 315750000978 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315750000979 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750000980 dimer interface [polypeptide binding]; other site 315750000981 putative CheW interface [polypeptide binding]; other site 315750000982 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 315750000983 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 315750000984 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 315750000985 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 315750000986 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 315750000987 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 315750000988 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 315750000989 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 315750000990 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750000991 Walker A/P-loop; other site 315750000992 ATP binding site [chemical binding]; other site 315750000993 Q-loop/lid; other site 315750000994 ABC transporter signature motif; other site 315750000995 Walker B; other site 315750000996 D-loop; other site 315750000997 H-loop/switch region; other site 315750000998 TOBE domain; Region: TOBE_2; cl01440 315750000999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750001000 dimer interface [polypeptide binding]; other site 315750001001 conserved gate region; other site 315750001002 putative PBP binding loops; other site 315750001003 ABC-ATPase subunit interface; other site 315750001004 peptide synthase; Provisional; Region: PRK12467 315750001005 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315750001006 AMP-binding enzyme; Region: AMP-binding; cl15778 315750001007 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315750001008 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315750001009 AMP-binding enzyme; Region: AMP-binding; cl15778 315750001010 AMP-binding enzyme; Region: AMP-binding; cl15778 315750001011 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315750001012 peptide synthase; Provisional; Region: PRK12316 315750001013 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315750001014 AMP-binding enzyme; Region: AMP-binding; cl15778 315750001015 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315750001016 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 315750001017 peptide synthase; Provisional; Region: PRK12467 315750001018 AMP-binding enzyme; Region: AMP-binding; cl15778 315750001019 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315750001020 peptide synthase; Provisional; Region: PRK12467 315750001021 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315750001022 AMP-binding enzyme; Region: AMP-binding; cl15778 315750001023 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315750001024 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315750001025 AMP-binding enzyme; Region: AMP-binding; cl15778 315750001026 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315750001027 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 315750001028 peptide synthase; Provisional; Region: PRK12467 315750001029 AMP-binding enzyme; Region: AMP-binding; cl15778 315750001030 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315750001031 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 315750001032 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 315750001033 AMP-binding enzyme; Region: AMP-binding; cl15778 315750001034 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 315750001035 putative NADP binding site [chemical binding]; other site 315750001036 active site 315750001037 peptide synthase; Provisional; Region: PRK12467 315750001038 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315750001039 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315750001040 AMP-binding enzyme; Region: AMP-binding; cl15778 315750001041 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315750001042 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 315750001043 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 315750001044 AMP-binding enzyme; Region: AMP-binding; cl15778 315750001045 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 315750001046 putative NADP binding site [chemical binding]; other site 315750001047 active site 315750001048 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315750001049 Condensation domain; Region: Condensation; pfam00668 315750001050 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 315750001051 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315750001052 AMP-binding enzyme; Region: AMP-binding; cl15778 315750001053 AMP-binding enzyme; Region: AMP-binding; cl15778 315750001054 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315750001055 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 315750001056 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 315750001057 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 315750001058 EamA-like transporter family; Region: EamA; cl01037 315750001059 EamA-like transporter family; Region: EamA; cl01037 315750001060 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 315750001061 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315750001062 DNA-binding site [nucleotide binding]; DNA binding site 315750001063 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315750001064 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750001065 homodimer interface [polypeptide binding]; other site 315750001066 catalytic residue [active] 315750001067 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 315750001068 Predicted membrane protein [Function unknown]; Region: COG2364 315750001069 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315750001070 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 315750001071 active site 315750001072 catalytic site [active] 315750001073 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 315750001074 FtsX-like permease family; Region: FtsX; cl15850 315750001075 FtsX-like permease family; Region: FtsX; cl15850 315750001076 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315750001077 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 315750001078 Walker A/P-loop; other site 315750001079 ATP binding site [chemical binding]; other site 315750001080 Q-loop/lid; other site 315750001081 ABC transporter signature motif; other site 315750001082 Walker B; other site 315750001083 D-loop; other site 315750001084 H-loop/switch region; other site 315750001085 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 315750001086 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 315750001087 Walker A/P-loop; other site 315750001088 ATP binding site [chemical binding]; other site 315750001089 Q-loop/lid; other site 315750001090 ABC transporter signature motif; other site 315750001091 Walker B; other site 315750001092 D-loop; other site 315750001093 H-loop/switch region; other site 315750001094 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 315750001095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750001096 dimer interface [polypeptide binding]; other site 315750001097 conserved gate region; other site 315750001098 putative PBP binding loops; other site 315750001099 ABC-ATPase subunit interface; other site 315750001100 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 315750001101 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 315750001102 substrate binding pocket [chemical binding]; other site 315750001103 membrane-bound complex binding site; other site 315750001104 hinge residues; other site 315750001105 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 315750001106 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 315750001107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750001108 putative substrate translocation pore; other site 315750001109 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 315750001110 Right handed beta helix region; Region: Beta_helix; pfam13229 315750001111 Right handed beta helix region; Region: Beta_helix; pfam13229 315750001112 Right handed beta helix region; Region: Beta_helix; pfam13229 315750001113 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 315750001114 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 315750001115 active site 315750001116 non-prolyl cis peptide bond; other site 315750001117 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315750001118 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 315750001119 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 315750001120 substrate binding pocket [chemical binding]; other site 315750001121 membrane-bound complex binding site; other site 315750001122 hinge residues; other site 315750001123 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 315750001124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750001125 dimer interface [polypeptide binding]; other site 315750001126 conserved gate region; other site 315750001127 putative PBP binding loops; other site 315750001128 ABC-ATPase subunit interface; other site 315750001129 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 315750001130 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 315750001131 Walker A/P-loop; other site 315750001132 ATP binding site [chemical binding]; other site 315750001133 Q-loop/lid; other site 315750001134 ABC transporter signature motif; other site 315750001135 Walker B; other site 315750001136 D-loop; other site 315750001137 H-loop/switch region; other site 315750001138 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 315750001139 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 315750001140 metal binding site [ion binding]; metal-binding site 315750001141 dimer interface [polypeptide binding]; other site 315750001142 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 315750001143 Transposase domain (DUF772); Region: DUF772; pfam05598 315750001144 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 315750001145 DDE superfamily endonuclease; Region: DDE_4; cl15789 315750001146 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315750001147 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750001148 active site 315750001149 phosphorylation site [posttranslational modification] 315750001150 intermolecular recognition site; other site 315750001151 dimerization interface [polypeptide binding]; other site 315750001152 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315750001153 DNA binding site [nucleotide binding] 315750001154 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 315750001155 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315750001156 dimerization interface [polypeptide binding]; other site 315750001157 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 315750001158 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315750001159 dimer interface [polypeptide binding]; other site 315750001160 phosphorylation site [posttranslational modification] 315750001161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750001162 ATP binding site [chemical binding]; other site 315750001163 Mg2+ binding site [ion binding]; other site 315750001164 G-X-G motif; other site 315750001165 GAF domain; Region: GAF_2; pfam13185 315750001166 GAF domain; Region: GAF; cl15785 315750001167 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 315750001168 aspartate kinase; Reviewed; Region: PRK09034 315750001169 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 315750001170 putative catalytic residues [active] 315750001171 putative nucleotide binding site [chemical binding]; other site 315750001172 putative aspartate binding site [chemical binding]; other site 315750001173 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 315750001174 allosteric regulatory residue; other site 315750001175 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 315750001176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750001177 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 315750001178 putative substrate translocation pore; other site 315750001179 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750001180 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750001181 Helix-turn-helix domains; Region: HTH; cl00088 315750001182 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315750001183 dimerization interface [polypeptide binding]; other site 315750001184 putative DNA binding site [nucleotide binding]; other site 315750001185 putative Zn2+ binding site [ion binding]; other site 315750001186 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 315750001187 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315750001188 DNA-binding site [nucleotide binding]; DNA binding site 315750001189 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315750001190 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750001191 homodimer interface [polypeptide binding]; other site 315750001192 catalytic residue [active] 315750001193 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 315750001194 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315750001195 inhibitor-cofactor binding pocket; inhibition site 315750001196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750001197 catalytic residue [active] 315750001198 amino acid transporter; Region: 2A0306; TIGR00909 315750001199 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 315750001200 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 315750001201 tetramerization interface [polypeptide binding]; other site 315750001202 NAD(P) binding site [chemical binding]; other site 315750001203 catalytic residues [active] 315750001204 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 315750001205 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 315750001206 Bacterial Ig-like domain; Region: Big_5; cl01012 315750001207 Copper resistance protein D; Region: CopD; cl00563 315750001208 FixH; Region: FixH; cl01254 315750001209 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 315750001210 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 315750001211 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 315750001212 active site 315750001213 P-loop; other site 315750001214 phosphorylation site [posttranslational modification] 315750001215 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 315750001216 active site 315750001217 phosphorylation site [posttranslational modification] 315750001218 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 315750001219 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 315750001220 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 315750001221 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 315750001222 Cache domain; Region: Cache_2; cl07034 315750001223 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 315750001224 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315750001225 dimerization interface [polypeptide binding]; other site 315750001226 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315750001227 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750001228 dimer interface [polypeptide binding]; other site 315750001229 putative CheW interface [polypeptide binding]; other site 315750001230 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 315750001231 homotrimer interaction site [polypeptide binding]; other site 315750001232 putative active site [active] 315750001233 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315750001234 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 315750001235 active site 315750001236 metal binding site [ion binding]; metal-binding site 315750001237 Excalibur calcium-binding domain; Region: Excalibur; cl05460 315750001238 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750001239 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 315750001240 active site 315750001241 motif I; other site 315750001242 motif II; other site 315750001243 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 315750001244 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 315750001245 putative active site [active] 315750001246 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 315750001247 Protein of unknown function (DUF1445); Region: DUF1445; cl01790 315750001248 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 315750001249 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 315750001250 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 315750001251 Transcriptional regulator [Transcription]; Region: IclR; COG1414 315750001252 Helix-turn-helix domains; Region: HTH; cl00088 315750001253 Bacterial transcriptional regulator; Region: IclR; pfam01614 315750001254 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 315750001255 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 315750001256 active site 315750001257 catalytic triad [active] 315750001258 oxyanion hole [active] 315750001259 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 315750001260 active site 315750001261 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 315750001262 Helix-turn-helix domains; Region: HTH; cl00088 315750001263 Helix-turn-helix domains; Region: HTH; cl00088 315750001264 PRD domain; Region: PRD; cl15445 315750001265 PRD domain; Region: PRD; cl15445 315750001266 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 315750001267 active site 315750001268 P-loop; other site 315750001269 phosphorylation site [posttranslational modification] 315750001270 Methyltransferase domain; Region: Methyltransf_31; pfam13847 315750001271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750001272 S-adenosylmethionine binding site [chemical binding]; other site 315750001273 short chain dehydrogenase; Provisional; Region: PRK06701 315750001274 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 315750001275 NAD binding site [chemical binding]; other site 315750001276 metal binding site [ion binding]; metal-binding site 315750001277 active site 315750001278 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 315750001279 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 315750001280 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 315750001281 Transcriptional regulators [Transcription]; Region: GntR; COG1802 315750001282 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315750001283 DNA-binding site [nucleotide binding]; DNA binding site 315750001284 FCD domain; Region: FCD; cl11656 315750001285 tartrate dehydrogenase; Provisional; Region: PRK08194 315750001286 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 315750001287 DNA topoisomerase III; Provisional; Region: PRK07726 315750001288 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 315750001289 active site 315750001290 putative interdomain interaction site [polypeptide binding]; other site 315750001291 putative metal-binding site [ion binding]; other site 315750001292 putative nucleotide binding site [chemical binding]; other site 315750001293 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 315750001294 domain I; other site 315750001295 DNA binding groove [nucleotide binding] 315750001296 phosphate binding site [ion binding]; other site 315750001297 domain II; other site 315750001298 domain III; other site 315750001299 nucleotide binding site [chemical binding]; other site 315750001300 catalytic site [active] 315750001301 domain IV; other site 315750001302 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 315750001303 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 315750001304 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 315750001305 metal binding site [ion binding]; metal-binding site 315750001306 active site 315750001307 I-site; other site 315750001308 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 315750001309 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 315750001310 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 315750001311 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 315750001312 DXD motif; other site 315750001313 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 315750001314 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 315750001315 possible YdaO-YuaA riboswitch; BPUM_nc0004 315750001316 Amino acid permease; Region: AA_permease_2; pfam13520 315750001317 pyruvate oxidase; Provisional; Region: PRK08611 315750001318 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 315750001319 PYR/PP interface [polypeptide binding]; other site 315750001320 dimer interface [polypeptide binding]; other site 315750001321 tetramer interface [polypeptide binding]; other site 315750001322 TPP binding site [chemical binding]; other site 315750001323 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 315750001324 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 315750001325 TPP-binding site [chemical binding]; other site 315750001326 Uncharacterized conserved protein [Function unknown]; Region: COG5444 315750001327 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 315750001328 Uncharacterized protein conserved in bacteria (DUF2247); Region: DUF2247; cl01763 315750001329 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315750001330 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315750001331 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 315750001332 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 315750001333 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 315750001334 EcsC protein family; Region: EcsC; pfam12787 315750001335 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 315750001336 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 315750001337 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 315750001338 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 315750001339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750001340 ATP binding site [chemical binding]; other site 315750001341 Mg2+ binding site [ion binding]; other site 315750001342 G-X-G motif; other site 315750001343 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 315750001344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750001345 active site 315750001346 phosphorylation site [posttranslational modification] 315750001347 intermolecular recognition site; other site 315750001348 dimerization interface [polypeptide binding]; other site 315750001349 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 315750001350 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 315750001351 Domain of unknown function DUF20; Region: UPF0118; pfam01594 315750001352 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 315750001353 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 315750001354 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315750001355 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750001356 Walker A/P-loop; other site 315750001357 ATP binding site [chemical binding]; other site 315750001358 Q-loop/lid; other site 315750001359 ABC transporter signature motif; other site 315750001360 Walker B; other site 315750001361 D-loop; other site 315750001362 H-loop/switch region; other site 315750001363 ABC-2 type transporter; Region: ABC2_membrane; cl11417 315750001364 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 315750001365 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 315750001366 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 315750001367 catalytic residues [active] 315750001368 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 315750001369 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 315750001370 ATP-grasp domain; Region: ATP-grasp_4; cl03087 315750001371 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 315750001372 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 315750001373 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 315750001374 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 315750001375 Esterase/lipase [General function prediction only]; Region: COG1647 315750001376 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315750001377 helicase 45; Provisional; Region: PTZ00424 315750001378 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 315750001379 ATP binding site [chemical binding]; other site 315750001380 Mg++ binding site [ion binding]; other site 315750001381 motif III; other site 315750001382 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315750001383 nucleotide binding region [chemical binding]; other site 315750001384 ATP-binding site [chemical binding]; other site 315750001385 Bacterial PH domain; Region: DUF304; cl01348 315750001386 Predicted membrane protein [Function unknown]; Region: COG3428 315750001387 Bacterial PH domain; Region: DUF304; cl01348 315750001388 Bacterial PH domain; Region: DUF304; cl01348 315750001389 Bacterial PH domain; Region: DUF304; cl01348 315750001390 Rhomboid family; Region: Rhomboid; cl11446 315750001391 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 315750001392 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 315750001393 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 315750001394 alanine racemase; Region: alr; TIGR00492 315750001395 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 315750001396 active site 315750001397 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 315750001398 dimer interface [polypeptide binding]; other site 315750001399 substrate binding site [chemical binding]; other site 315750001400 catalytic residues [active] 315750001401 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 315750001402 PemK-like protein; Region: PemK; cl00995 315750001403 Rsbr N terminal; Region: Rsbr_N; pfam08678 315750001404 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 315750001405 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 315750001406 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 315750001407 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750001408 ATP binding site [chemical binding]; other site 315750001409 Mg2+ binding site [ion binding]; other site 315750001410 G-X-G motif; other site 315750001411 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 315750001412 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 315750001413 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 315750001414 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 315750001415 anti sigma factor interaction site; other site 315750001416 regulatory phosphorylation site [posttranslational modification]; other site 315750001417 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 315750001418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750001419 ATP binding site [chemical binding]; other site 315750001420 Mg2+ binding site [ion binding]; other site 315750001421 G-X-G motif; other site 315750001422 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 315750001423 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315750001424 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 315750001425 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315750001426 DNA binding residues [nucleotide binding] 315750001427 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 315750001428 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 315750001429 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 315750001430 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 315750001431 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 315750001432 RNA binding site [nucleotide binding]; other site 315750001433 hypothetical protein; Provisional; Region: PRK04351 315750001434 SprT homologues; Region: SprT; cl01182 315750001435 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 315750001436 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 315750001437 tetramer interface [polypeptide binding]; other site 315750001438 TPP-binding site [chemical binding]; other site 315750001439 heterodimer interface [polypeptide binding]; other site 315750001440 phosphorylation loop region [posttranslational modification] 315750001441 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 315750001442 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 315750001443 alpha subunit interface [polypeptide binding]; other site 315750001444 TPP binding site [chemical binding]; other site 315750001445 heterodimer interface [polypeptide binding]; other site 315750001446 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 315750001447 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 315750001448 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 315750001449 E3 interaction surface; other site 315750001450 lipoyl attachment site [posttranslational modification]; other site 315750001451 e3 binding domain; Region: E3_binding; pfam02817 315750001452 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 315750001453 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 315750001454 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750001455 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315750001456 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 315750001457 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 315750001458 GAF domain; Region: GAF; cl15785 315750001459 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750001460 Walker A motif; other site 315750001461 ATP binding site [chemical binding]; other site 315750001462 Walker B motif; other site 315750001463 arginine finger; other site 315750001464 Helix-turn-helix domains; Region: HTH; cl00088 315750001465 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315750001466 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 315750001467 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 315750001468 DNA-binding site [nucleotide binding]; DNA binding site 315750001469 RNA-binding motif; other site 315750001470 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 315750001471 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 315750001472 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 315750001473 putative NAD(P) binding site [chemical binding]; other site 315750001474 putative substrate binding site [chemical binding]; other site 315750001475 catalytic Zn binding site [ion binding]; other site 315750001476 structural Zn binding site [ion binding]; other site 315750001477 dimer interface [polypeptide binding]; other site 315750001478 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 315750001479 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 315750001480 DNA binding residues [nucleotide binding] 315750001481 putative dimer interface [polypeptide binding]; other site 315750001482 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 315750001483 active site 315750001484 active site 315750001485 catalytic residues [active] 315750001486 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750001487 Helix-turn-helix domains; Region: HTH; cl00088 315750001488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750001489 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 315750001490 putative substrate translocation pore; other site 315750001491 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315750001492 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 315750001493 substrate binding pocket [chemical binding]; other site 315750001494 Protein of unknown function (DUF419); Region: DUF419; cl15265 315750001495 classical (c) SDRs; Region: SDR_c; cd05233 315750001496 NAD(P) binding site [chemical binding]; other site 315750001497 active site 315750001498 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 315750001499 active site 315750001500 homotetramer interface [polypeptide binding]; other site 315750001501 homodimer interface [polypeptide binding]; other site 315750001502 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315750001503 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315750001504 Transcriptional regulators [Transcription]; Region: MarR; COG1846 315750001505 Helix-turn-helix domains; Region: HTH; cl00088 315750001506 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750001507 Helix-turn-helix domains; Region: HTH; cl00088 315750001508 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 315750001509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750001510 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315750001511 putative substrate translocation pore; other site 315750001512 Protein of unknown function (DUF627); Region: DUF627; pfam04781 315750001513 LytTr DNA-binding domain; Region: LytTR; cl04498 315750001514 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315750001515 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 315750001516 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750001517 Coenzyme A binding pocket [chemical binding]; other site 315750001518 YesK-like protein; Region: YesK; pfam14150 315750001519 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315750001520 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315750001521 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 315750001522 dimer interface [polypeptide binding]; other site 315750001523 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315750001524 metal binding site [ion binding]; metal-binding site 315750001525 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315750001526 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 315750001527 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 315750001528 NADP+ binding site [chemical binding]; other site 315750001529 folate binding site [chemical binding]; other site 315750001530 Transcriptional regulators [Transcription]; Region: MarR; COG1846 315750001531 Helix-turn-helix domains; Region: HTH; cl00088 315750001532 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 315750001533 dimer interface [polypeptide binding]; other site 315750001534 FMN binding site [chemical binding]; other site 315750001535 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 315750001536 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 315750001537 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 315750001538 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 315750001539 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315750001540 non-specific DNA binding site [nucleotide binding]; other site 315750001541 salt bridge; other site 315750001542 sequence-specific DNA binding site [nucleotide binding]; other site 315750001543 Anabaena sensory rhodopsin transducer; Region: ASRT; cl01751 315750001544 Cupin domain; Region: Cupin_2; cl09118 315750001545 LysE type translocator; Region: LysE; cl00565 315750001546 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 315750001547 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750001548 Coenzyme A binding pocket [chemical binding]; other site 315750001549 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 315750001550 Helix-turn-helix domains; Region: HTH; cl00088 315750001551 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 315750001552 dimerization interface [polypeptide binding]; other site 315750001553 substrate binding pocket [chemical binding]; other site 315750001554 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 315750001555 active site 315750001556 catalytic tetrad [active] 315750001557 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 315750001558 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 315750001559 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 315750001560 AzlC protein; Region: AzlC; cl00570 315750001561 EamA-like transporter family; Region: EamA; cl01037 315750001562 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 315750001563 EamA-like transporter family; Region: EamA; cl01037 315750001564 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 315750001565 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 315750001566 YaaC-like Protein; Region: YaaC; pfam14175 315750001567 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 315750001568 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 315750001569 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 315750001570 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 315750001571 active site 315750001572 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 315750001573 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315750001574 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 315750001575 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 315750001576 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315750001577 DNA-binding site [nucleotide binding]; DNA binding site 315750001578 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315750001579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750001580 homodimer interface [polypeptide binding]; other site 315750001581 catalytic residue [active] 315750001582 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 315750001583 active site 315750001584 multimer interface [polypeptide binding]; other site 315750001585 imidazole glycerol phosphate synthase subunit hisH; Provisional; Region: hisH; CHL00188 315750001586 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 315750001587 predicted active site [active] 315750001588 catalytic triad [active] 315750001589 seryl-tRNA synthetase; Provisional; Region: PRK05431 315750001590 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 315750001591 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 315750001592 dimer interface [polypeptide binding]; other site 315750001593 active site 315750001594 motif 1; other site 315750001595 motif 2; other site 315750001596 motif 3; other site 315750001597 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750001598 dimer interface [polypeptide binding]; other site 315750001599 putative CheW interface [polypeptide binding]; other site 315750001600 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 315750001601 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 315750001602 Substrate-binding site [chemical binding]; other site 315750001603 Substrate specificity [chemical binding]; other site 315750001604 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 315750001605 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 315750001606 Substrate-binding site [chemical binding]; other site 315750001607 Substrate specificity [chemical binding]; other site 315750001608 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 315750001609 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 315750001610 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 315750001611 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 315750001612 active site 315750001613 Isochorismatase family; Region: Isochorismatase; pfam00857 315750001614 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 315750001615 catalytic triad [active] 315750001616 conserved cis-peptide bond; other site 315750001617 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 315750001618 nucleoside/Zn binding site; other site 315750001619 dimer interface [polypeptide binding]; other site 315750001620 catalytic motif [active] 315750001621 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 315750001622 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750001623 Walker A motif; other site 315750001624 ATP binding site [chemical binding]; other site 315750001625 Walker B motif; other site 315750001626 arginine finger; other site 315750001627 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 315750001628 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 315750001629 recombination protein RecR; Reviewed; Region: recR; PRK00076 315750001630 RecR protein; Region: RecR; pfam02132 315750001631 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 315750001632 putative active site [active] 315750001633 putative metal-binding site [ion binding]; other site 315750001634 tetramer interface [polypeptide binding]; other site 315750001635 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 315750001636 SigmaK-factor processing regulatory protein BofA; Region: BofA; cl06466 315750001637 thiamine monophosphate kinase; Provisional; Region: PRK05731 315750001638 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 315750001639 ATP binding site [chemical binding]; other site 315750001640 dimerization interface [polypeptide binding]; other site 315750001641 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 315750001642 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 315750001643 Glycoprotease family; Region: Peptidase_M22; pfam00814 315750001644 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 315750001645 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750001646 Coenzyme A binding pocket [chemical binding]; other site 315750001647 UGMP family protein; Validated; Region: PRK09604 315750001648 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 315750001649 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 315750001650 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 315750001651 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 315750001652 ABC transporter; Region: ABC_tran_2; pfam12848 315750001653 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 315750001654 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 315750001655 trimer interface [polypeptide binding]; other site 315750001656 dimer interface [polypeptide binding]; other site 315750001657 putative active site [active] 315750001658 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 315750001659 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 315750001660 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750001661 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 315750001662 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 315750001663 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 315750001664 nudix motif; other site 315750001665 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 315750001666 CAAX protease self-immunity; Region: Abi; cl00558 315750001667 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 315750001668 oligomerisation interface [polypeptide binding]; other site 315750001669 mobile loop; other site 315750001670 roof hairpin; other site 315750001671 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 315750001672 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 315750001673 ring oligomerisation interface [polypeptide binding]; other site 315750001674 ATP/Mg binding site [chemical binding]; other site 315750001675 stacking interactions; other site 315750001676 hinge regions; other site 315750001677 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 315750001678 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 315750001679 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 315750001680 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 315750001681 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 315750001682 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 315750001683 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 315750001684 Cation efflux family; Region: Cation_efflux; cl00316 315750001685 MoxR-like ATPases [General function prediction only]; Region: COG0714 315750001686 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750001687 Walker A motif; other site 315750001688 ATP binding site [chemical binding]; other site 315750001689 Walker B motif; other site 315750001690 arginine finger; other site 315750001691 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 315750001692 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 315750001693 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 315750001694 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 315750001695 GMP synthase; Reviewed; Region: guaA; PRK00074 315750001696 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 315750001697 AMP/PPi binding site [chemical binding]; other site 315750001698 candidate oxyanion hole; other site 315750001699 catalytic triad [active] 315750001700 potential glutamine specificity residues [chemical binding]; other site 315750001701 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 315750001702 ATP Binding subdomain [chemical binding]; other site 315750001703 Ligand Binding sites [chemical binding]; other site 315750001704 Dimerization subdomain; other site 315750001705 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315750001706 non-specific DNA binding site [nucleotide binding]; other site 315750001707 salt bridge; other site 315750001708 sequence-specific DNA binding site [nucleotide binding]; other site 315750001709 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315750001710 sequence-specific DNA binding site [nucleotide binding]; other site 315750001711 salt bridge; other site 315750001712 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750001713 Replication initiation factor; Region: Rep_trans; pfam02486 315750001714 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 315750001715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 315750001716 cofactor binding site; other site 315750001717 DNA binding site [nucleotide binding] 315750001718 substrate interaction site [chemical binding]; other site 315750001719 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 315750001720 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750001721 Walker A motif; other site 315750001722 ATP binding site [chemical binding]; other site 315750001723 Walker B motif; other site 315750001724 Domain of unknown function (DUF4320); Region: DUF4320; pfam14208 315750001725 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 315750001726 TcpE family; Region: TcpE; pfam12648 315750001727 hypothetical protein; Provisional; Region: PHA02940 315750001728 AAA-like domain; Region: AAA_10; pfam12846 315750001729 Ring-infected erythrocyte surface antigen; Provisional; Region: PTZ00341 315750001730 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 315750001731 N-acetyl-D-glucosamine binding site [chemical binding]; other site 315750001732 catalytic residue [active] 315750001733 NlpC/P60 family; Region: NLPC_P60; cl11438 315750001734 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 315750001735 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 315750001736 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 315750001737 Int/Topo IB signature motif; other site 315750001738 Cupin domain; Region: Cupin_2; cl09118 315750001739 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 315750001740 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315750001741 2-isopropylmalate synthase; Validated; Region: PRK03739 315750001742 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 315750001743 active site 315750001744 catalytic residues [active] 315750001745 metal binding site [ion binding]; metal-binding site 315750001746 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 315750001747 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315750001748 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 315750001749 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315750001750 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315750001751 Helix-turn-helix domain; Region: HTH_18; pfam12833 315750001752 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 315750001753 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315750001754 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315750001755 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315750001756 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315750001757 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 315750001758 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315750001759 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315750001760 DNA binding residues [nucleotide binding] 315750001761 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 315750001762 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 315750001763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750001764 putative substrate translocation pore; other site 315750001765 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315750001766 Helix-turn-helix domains; Region: HTH; cl00088 315750001767 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315750001768 dimerization interface [polypeptide binding]; other site 315750001769 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 315750001770 hypothetical protein; Provisional; Region: PRK04164 315750001771 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 315750001772 NETI protein; Region: NETI; pfam14044 315750001773 AIR carboxylase; Region: AIRC; cl00310 315750001774 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 315750001775 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750001776 ATP-grasp domain; Region: ATP-grasp_4; cl03087 315750001777 adenylosuccinate lyase; Provisional; Region: PRK07492 315750001778 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 315750001779 tetramer interface [polypeptide binding]; other site 315750001780 active site 315750001781 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 315750001782 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 315750001783 ATP binding site [chemical binding]; other site 315750001784 active site 315750001785 substrate binding site [chemical binding]; other site 315750001786 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 315750001787 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 315750001788 putative active site [active] 315750001789 catalytic triad [active] 315750001790 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 315750001791 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 315750001792 dimerization interface [polypeptide binding]; other site 315750001793 ATP binding site [chemical binding]; other site 315750001794 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 315750001795 dimerization interface [polypeptide binding]; other site 315750001796 ATP binding site [chemical binding]; other site 315750001797 amidophosphoribosyltransferase; Provisional; Region: PRK07631 315750001798 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 315750001799 active site 315750001800 tetramer interface [polypeptide binding]; other site 315750001801 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315750001802 active site 315750001803 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 315750001804 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 315750001805 dimerization interface [polypeptide binding]; other site 315750001806 putative ATP binding site [chemical binding]; other site 315750001807 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 315750001808 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 315750001809 active site 315750001810 substrate binding site [chemical binding]; other site 315750001811 cosubstrate binding site; other site 315750001812 catalytic site [active] 315750001813 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 315750001814 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 315750001815 purine monophosphate binding site [chemical binding]; other site 315750001816 dimer interface [polypeptide binding]; other site 315750001817 putative catalytic residues [active] 315750001818 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 315750001819 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 315750001820 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 315750001821 ATP-grasp domain; Region: ATP-grasp_4; cl03087 315750001822 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 315750001823 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 315750001824 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315750001825 ATP binding site [chemical binding]; other site 315750001826 putative Mg++ binding site [ion binding]; other site 315750001827 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 315750001828 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315750001829 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 315750001830 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 315750001831 Helix-turn-helix domains; Region: HTH; cl00088 315750001832 hypothetical protein; Provisional; Region: PRK06917 315750001833 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315750001834 inhibitor-cofactor binding pocket; inhibition site 315750001835 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750001836 catalytic residue [active] 315750001837 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 315750001838 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 315750001839 acetylornithine deacetylase; Validated; Region: PRK06915 315750001840 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 315750001841 metal binding site [ion binding]; metal-binding site 315750001842 dimer interface [polypeptide binding]; other site 315750001843 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 315750001844 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 315750001845 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 315750001846 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 315750001847 active site 315750001848 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 315750001849 Helix-turn-helix domains; Region: HTH; cl00088 315750001850 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 315750001851 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 315750001852 active site 315750001853 FMN binding site [chemical binding]; other site 315750001854 substrate binding site [chemical binding]; other site 315750001855 3Fe-4S cluster binding site [ion binding]; other site 315750001856 Protein of unknown function (DUF2283); Region: DUF2283; cl02251 315750001857 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 315750001858 substrate binding site [chemical binding]; other site 315750001859 putative active site [active] 315750001860 dimer interface [polypeptide binding]; other site 315750001861 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 315750001862 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750001863 Family description; Region: UvrD_C_2; cl15862 315750001864 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 315750001865 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 315750001866 nucleotide binding pocket [chemical binding]; other site 315750001867 K-X-D-G motif; other site 315750001868 catalytic site [active] 315750001869 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 315750001870 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 315750001871 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 315750001872 Dimer interface [polypeptide binding]; other site 315750001873 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 315750001874 H+ Antiporter protein; Region: 2A0121; TIGR00900 315750001875 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750001876 peptide synthase; Provisional; Region: PRK12316 315750001877 AMP-binding enzyme; Region: AMP-binding; cl15778 315750001878 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315750001879 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 315750001880 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 315750001881 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315750001882 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 315750001883 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 315750001884 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750001885 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 315750001886 FkbH-like domain; Region: FkbH; TIGR01686 315750001887 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750001888 active site 315750001889 motif I; other site 315750001890 motif II; other site 315750001891 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315750001892 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 315750001893 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 315750001894 active site 315750001895 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 315750001896 AMP-binding enzyme; Region: AMP-binding; cl15778 315750001897 acyl-CoA synthetase; Validated; Region: PRK08308 315750001898 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315750001899 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 315750001900 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 315750001901 active site 315750001902 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 315750001903 Acyl transferase domain; Region: Acyl_transf_1; cl08282 315750001904 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 315750001905 putative NADP binding site [chemical binding]; other site 315750001906 active site 315750001907 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315750001908 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 315750001909 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 315750001910 active site 315750001911 Acyl transferase domain; Region: Acyl_transf_1; cl08282 315750001912 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315750001913 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 315750001914 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 315750001915 active site 315750001916 Acyl transferase domain; Region: Acyl_transf_1; cl08282 315750001917 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 315750001918 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 315750001919 putative NADP binding site [chemical binding]; other site 315750001920 active site 315750001921 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315750001922 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 315750001923 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 315750001924 active site 315750001925 Acyl transferase domain; Region: Acyl_transf_1; cl08282 315750001926 peptide synthase; Provisional; Region: PRK12467 315750001927 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315750001928 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315750001929 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 315750001930 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 315750001931 peptide synthase; Provisional; Region: PRK12316 315750001932 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315750001933 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315750001934 active site 315750001935 ATP binding site [chemical binding]; other site 315750001936 substrate binding site [chemical binding]; other site 315750001937 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 315750001938 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 315750001939 dimer interface [polypeptide binding]; other site 315750001940 active site 315750001941 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 315750001942 MgtC family; Region: MgtC; pfam02308 315750001943 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 315750001944 Na binding site [ion binding]; other site 315750001945 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 315750001946 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 315750001947 Amidase; Region: Amidase; cl11426 315750001948 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 315750001949 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 315750001950 GatB domain; Region: GatB_Yqey; cl11497 315750001951 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750001952 Helix-turn-helix domains; Region: HTH; cl00088 315750001953 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 315750001954 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 315750001955 Protein export membrane protein; Region: SecD_SecF; cl14618 315750001956 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 315750001957 active site 315750001958 dimerization interface [polypeptide binding]; other site 315750001959 putative lipid kinase; Reviewed; Region: PRK13337 315750001960 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 315750001961 TRAM domain; Region: TRAM; cl01282 315750001962 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 315750001963 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750001964 S-adenosylmethionine binding site [chemical binding]; other site 315750001965 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750001966 ATP binding site [chemical binding]; other site 315750001967 Mg2+ binding site [ion binding]; other site 315750001968 G-X-G motif; other site 315750001969 Z1 domain; Region: Z1; pfam10593 315750001970 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 315750001971 AIPR protein; Region: AIPR; pfam10592 315750001972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 315750001973 cofactor binding site; other site 315750001974 DNA binding site [nucleotide binding] 315750001975 substrate interaction site [chemical binding]; other site 315750001976 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 315750001977 substrate interaction site [chemical binding]; other site 315750001978 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 315750001979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 315750001980 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 315750001981 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 315750001982 FMN binding site [chemical binding]; other site 315750001983 active site 315750001984 catalytic residues [active] 315750001985 substrate binding site [chemical binding]; other site 315750001986 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 315750001987 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 315750001988 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 315750001989 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 315750001990 putative active site [active] 315750001991 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 315750001992 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 315750001993 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 315750001994 active site turn [active] 315750001995 phosphorylation site [posttranslational modification] 315750001996 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 315750001997 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 315750001998 NAD binding site [chemical binding]; other site 315750001999 sugar binding site [chemical binding]; other site 315750002000 divalent metal binding site [ion binding]; other site 315750002001 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 315750002002 dimer interface [polypeptide binding]; other site 315750002003 Predicted transcriptional regulator [Transcription]; Region: COG1959 315750002004 Helix-turn-helix domains; Region: HTH; cl00088 315750002005 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 315750002006 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 315750002007 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 315750002008 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 315750002009 NAD binding site [chemical binding]; other site 315750002010 sugar binding site [chemical binding]; other site 315750002011 divalent metal binding site [ion binding]; other site 315750002012 tetramer (dimer of dimers) interface [polypeptide binding]; other site 315750002013 dimer interface [polypeptide binding]; other site 315750002014 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 315750002015 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 315750002016 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 315750002017 putative active site [active] 315750002018 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 315750002019 putative deacylase active site [active] 315750002020 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315750002021 Helix-turn-helix domains; Region: HTH; cl00088 315750002022 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315750002023 dimerization interface [polypeptide binding]; other site 315750002024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750002025 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315750002026 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 315750002027 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 315750002028 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 315750002029 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 315750002030 substrate binding site; other site 315750002031 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 315750002032 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750002033 NAD(P) binding site [chemical binding]; other site 315750002034 active site 315750002035 Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; cl05288 315750002036 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 315750002037 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 315750002038 active site 315750002039 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 315750002040 Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; cl05288 315750002041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750002042 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315750002043 putative substrate translocation pore; other site 315750002044 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 315750002045 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 315750002046 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315750002047 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315750002048 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 315750002049 transmembrane helices; other site 315750002050 Spore germination protein GerPC; Region: GerPC; pfam10737 315750002051 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 315750002052 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 315750002053 putative dimer interface [polypeptide binding]; other site 315750002054 amino acid transporter; Region: 2A0306; TIGR00909 315750002055 Spore germination protein; Region: Spore_permease; cl15802 315750002056 Spore germination protein; Region: Spore_permease; cl15802 315750002057 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 315750002058 putative metal binding site; other site 315750002059 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750002060 binding surface 315750002061 TPR motif; other site 315750002062 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 315750002063 binding surface 315750002064 TPR motif; other site 315750002065 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 315750002066 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 315750002067 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 315750002068 ABC transporter; Region: ABC_tran_2; pfam12848 315750002069 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 315750002070 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 315750002071 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 315750002072 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315750002073 DNA binding residues [nucleotide binding] 315750002074 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 315750002075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750002076 putative substrate translocation pore; other site 315750002077 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 315750002078 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750002079 Walker A/P-loop; other site 315750002080 ATP binding site [chemical binding]; other site 315750002081 Q-loop/lid; other site 315750002082 ABC transporter signature motif; other site 315750002083 Walker B; other site 315750002084 D-loop; other site 315750002085 H-loop/switch region; other site 315750002086 ABC transporter; Region: ABC_tran_2; pfam12848 315750002087 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 315750002088 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 315750002089 DEAD-like helicases superfamily; Region: DEXDc; smart00487 315750002090 ATP binding site [chemical binding]; other site 315750002091 Mg++ binding site [ion binding]; other site 315750002092 motif III; other site 315750002093 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315750002094 nucleotide binding region [chemical binding]; other site 315750002095 ATP-binding site [chemical binding]; other site 315750002096 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 315750002097 Prostaglandin dehydrogenases; Region: PGDH; cd05288 315750002098 NAD(P) binding site [chemical binding]; other site 315750002099 substrate binding site [chemical binding]; other site 315750002100 dimer interface [polypeptide binding]; other site 315750002101 Protein of unknown function (DUF3212); Region: DUF3212; pfam11486 315750002102 Heat induced stress protein YflT; Region: YflT; pfam11181 315750002103 Predicted AdoMet-dependent methyltransferase; Region: AdoMet_MTase; pfam07757 315750002104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750002105 S-adenosylmethionine binding site [chemical binding]; other site 315750002106 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 315750002107 dimerization interface [polypeptide binding]; other site 315750002108 active site 315750002109 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 315750002110 structural tetrad; other site 315750002111 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 315750002112 structural tetrad; other site 315750002113 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 315750002114 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 315750002115 catalytic motif [active] 315750002116 Zn binding site [ion binding]; other site 315750002117 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 315750002118 BclB C-terminal domain; Region: exospore_TM; TIGR03721 315750002119 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 315750002120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750002121 ATP binding site [chemical binding]; other site 315750002122 Mg2+ binding site [ion binding]; other site 315750002123 G-X-G motif; other site 315750002124 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 315750002125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750002126 active site 315750002127 phosphorylation site [posttranslational modification] 315750002128 intermolecular recognition site; other site 315750002129 dimerization interface [polypeptide binding]; other site 315750002130 Helix-turn-helix domains; Region: HTH; cl00088 315750002131 NMT1-like family; Region: NMT1_2; cl15260 315750002132 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 315750002133 Citrate transporter; Region: CitMHS; pfam03600 315750002134 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 315750002135 active site 315750002136 Zn binding site [ion binding]; other site 315750002137 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 315750002138 Helix-turn-helix domains; Region: HTH; cl00088 315750002139 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 315750002140 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 315750002141 active site 315750002142 dimer interface [polypeptide binding]; other site 315750002143 Acylphosphatase; Region: Acylphosphatase; cl00551 315750002144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 315750002145 MOSC domain; Region: MOSC; pfam03473 315750002146 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 315750002147 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 315750002148 active site 315750002149 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 315750002150 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 315750002151 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 315750002152 active site turn [active] 315750002153 phosphorylation site [posttranslational modification] 315750002154 Protein of unknown function (DUF817); Region: DUF817; cl01520 315750002155 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 315750002156 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 315750002157 Sulfatase; Region: Sulfatase; cl10460 315750002158 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 315750002159 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 315750002160 catalytic residue [active] 315750002161 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 315750002162 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315750002163 dimerization interface [polypeptide binding]; other site 315750002164 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315750002165 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750002166 dimer interface [polypeptide binding]; other site 315750002167 putative CheW interface [polypeptide binding]; other site 315750002168 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 315750002169 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 315750002170 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 315750002171 active site turn [active] 315750002172 phosphorylation site [posttranslational modification] 315750002173 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 315750002174 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 315750002175 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 315750002176 Ca binding site [ion binding]; other site 315750002177 active site 315750002178 catalytic site [active] 315750002179 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 315750002180 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315750002181 DNA-binding site [nucleotide binding]; DNA binding site 315750002182 UTRA domain; Region: UTRA; cl01230 315750002183 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 315750002184 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 315750002185 active site 315750002186 metal binding site [ion binding]; metal-binding site 315750002187 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 315750002188 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 315750002189 active site 315750002190 metal binding site [ion binding]; metal-binding site 315750002191 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 315750002192 intracellular protease, PfpI family; Region: PfpI; TIGR01382 315750002193 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 315750002194 proposed catalytic triad [active] 315750002195 conserved cys residue [active] 315750002196 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 315750002197 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 315750002198 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 315750002199 Low molecular weight phosphatase family; Region: LMWPc; cd00115 315750002200 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 315750002201 active site 315750002202 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 315750002203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750002204 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315750002205 putative substrate translocation pore; other site 315750002206 OsmC-like protein; Region: OsmC; cl00767 315750002207 calcium/proton exchanger (cax); Region: cax; TIGR00378 315750002208 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 315750002209 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 315750002210 YfkD-like protein; Region: YfkD; pfam14167 315750002211 Transcriptional regulator; Region: Transcrip_reg; cl00361 315750002212 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 315750002213 Mechanosensitive ion channel; Region: MS_channel; pfam00924 315750002214 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 315750002215 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 315750002216 YfkB-like domain; Region: YfkB; pfam08756 315750002217 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 315750002218 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 315750002219 NodB motif; other site 315750002220 active site 315750002221 catalytic site [active] 315750002222 Cd binding site [ion binding]; other site 315750002223 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 315750002224 magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383 315750002225 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 315750002226 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 315750002227 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 315750002228 minor groove reading motif; other site 315750002229 helix-hairpin-helix signature motif; other site 315750002230 substrate binding pocket [chemical binding]; other site 315750002231 active site 315750002232 TRAM domain; Region: TRAM; cl01282 315750002233 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 315750002234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750002235 S-adenosylmethionine binding site [chemical binding]; other site 315750002236 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750002237 Helix-turn-helix domains; Region: HTH; cl00088 315750002238 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 315750002239 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 315750002240 putative NAD(P) binding site [chemical binding]; other site 315750002241 active site 315750002242 putative substrate binding site [chemical binding]; other site 315750002243 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315750002244 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 315750002245 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315750002246 DNA binding residues [nucleotide binding] 315750002247 drug binding residues [chemical binding]; other site 315750002248 dimer interface [polypeptide binding]; other site 315750002249 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 315750002250 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 315750002251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750002252 putative substrate translocation pore; other site 315750002253 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 315750002254 Protein of unknown function; Region: DUF3658; pfam12395 315750002255 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 315750002256 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 315750002257 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 315750002258 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 315750002259 active site 315750002260 dimer interface [polypeptide binding]; other site 315750002261 motif 1; other site 315750002262 motif 2; other site 315750002263 motif 3; other site 315750002264 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 315750002265 anticodon binding site; other site 315750002266 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 315750002267 Helix-turn-helix domains; Region: HTH; cl00088 315750002268 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 315750002269 Collagen binding domain; Region: Collagen_bind; pfam05737 315750002270 Collagen binding domain; Region: Collagen_bind; pfam05737 315750002271 Collagen binding domain; Region: Collagen_bind; pfam05737 315750002272 Collagen binding domain; Region: Collagen_bind; pfam05737 315750002273 Collagen binding domain; Region: Collagen_bind; pfam05737 315750002274 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315750002275 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315750002276 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315750002277 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315750002278 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315750002279 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315750002280 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315750002281 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315750002282 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315750002283 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315750002284 Gram positive anchor; Region: Gram_pos_anchor; cl15427 315750002285 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd06166 315750002286 active site 315750002287 catalytic site [active] 315750002288 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 315750002289 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 315750002290 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750002291 Helix-turn-helix domains; Region: HTH; cl00088 315750002292 VanZ like family; Region: VanZ; cl01971 315750002293 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 315750002294 active site 315750002295 catalytic triad [active] 315750002296 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 315750002297 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750002298 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315750002299 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 315750002300 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315750002301 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315750002302 DNA binding residues [nucleotide binding] 315750002303 Putative zinc-finger; Region: zf-HC2; cl15806 315750002304 putative anti-sigmaE protein; Provisional; Region: PRK13920 315750002305 Anti-sigma-K factor rskA; Region: RskA; pfam10099 315750002306 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 315750002307 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 315750002308 putative NAD(P) binding site [chemical binding]; other site 315750002309 dimer interface [polypeptide binding]; other site 315750002310 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 315750002311 DinB superfamily; Region: DinB_2; pfam12867 315750002312 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315750002313 Helix-turn-helix domains; Region: HTH; cl00088 315750002314 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 315750002315 Uncharacterized conserved protein [Function unknown]; Region: COG2898 315750002316 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 315750002317 Protein of unknown function, DUF393; Region: DUF393; cl01136 315750002318 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315750002319 non-specific DNA binding site [nucleotide binding]; other site 315750002320 salt bridge; other site 315750002321 sequence-specific DNA binding site [nucleotide binding]; other site 315750002322 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 315750002323 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 315750002324 putative FMN binding site [chemical binding]; other site 315750002325 YfhD-like protein; Region: YfhD; pfam14151 315750002326 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 315750002327 TIGR01777 family protein; Region: yfcH 315750002328 putative NAD(P) binding site [chemical binding]; other site 315750002329 putative active site [active] 315750002330 RecX family; Region: RecX; cl00936 315750002331 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 315750002332 YpzG-like protein; Region: YpzG; pfam14139 315750002333 Small acid-soluble spore protein K family; Region: SspK; cl11509 315750002334 WVELL protein; Region: WVELL; pfam14043 315750002335 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 315750002336 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 315750002337 Ligand binding site; other site 315750002338 Putative Catalytic site; other site 315750002339 DXD motif; other site 315750002340 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 315750002341 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 315750002342 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750002343 DinB superfamily; Region: DinB_2; pfam12867 315750002344 Regulatory protein YrvL; Region: YrvL; pfam14184 315750002345 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 315750002346 Cupin domain; Region: Cupin_2; cl09118 315750002347 Cupin domain; Region: Cupin_2; cl09118 315750002348 YvrJ protein family; Region: YvrJ; pfam12841 315750002349 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 315750002350 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315750002351 DNA binding residues [nucleotide binding] 315750002352 hypothetical protein; Provisional; Region: PRK14082 315750002353 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 315750002354 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 315750002355 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 315750002356 minor groove reading motif; other site 315750002357 helix-hairpin-helix signature motif; other site 315750002358 substrate binding pocket [chemical binding]; other site 315750002359 active site 315750002360 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 315750002361 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 315750002362 DNA binding and oxoG recognition site [nucleotide binding] 315750002363 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 315750002364 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 315750002365 putative NAD(P) binding site [chemical binding]; other site 315750002366 active site 315750002367 Transposase domain (DUF772); Region: DUF772; pfam05598 315750002368 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 315750002369 DDE superfamily endonuclease; Region: DDE_4; cl15789 315750002370 YgaB-like protein; Region: YgaB; pfam14182 315750002371 Protein of unknown function (DUF402); Region: DUF402; cl00979 315750002372 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 315750002373 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 315750002374 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 315750002375 Walker A/P-loop; other site 315750002376 ATP binding site [chemical binding]; other site 315750002377 Q-loop/lid; other site 315750002378 ABC transporter signature motif; other site 315750002379 Walker B; other site 315750002380 D-loop; other site 315750002381 H-loop/switch region; other site 315750002382 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 315750002383 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 315750002384 Walker A/P-loop; other site 315750002385 ATP binding site [chemical binding]; other site 315750002386 Q-loop/lid; other site 315750002387 ABC transporter signature motif; other site 315750002388 Walker B; other site 315750002389 D-loop; other site 315750002390 H-loop/switch region; other site 315750002391 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 315750002392 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 315750002393 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 315750002394 Walker A/P-loop; other site 315750002395 ATP binding site [chemical binding]; other site 315750002396 Q-loop/lid; other site 315750002397 ABC transporter signature motif; other site 315750002398 Walker B; other site 315750002399 D-loop; other site 315750002400 H-loop/switch region; other site 315750002401 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 315750002402 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 315750002403 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 315750002404 peptide binding site [polypeptide binding]; other site 315750002405 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 315750002406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 315750002407 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 315750002408 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 315750002409 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750002410 dimer interface [polypeptide binding]; other site 315750002411 conserved gate region; other site 315750002412 putative PBP binding loops; other site 315750002413 ABC-ATPase subunit interface; other site 315750002414 Predicted membrane protein [Function unknown]; Region: COG4129 315750002415 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 315750002416 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 315750002417 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315750002418 inhibitor-cofactor binding pocket; inhibition site 315750002419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750002420 catalytic residue [active] 315750002421 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 315750002422 catalytic triad [active] 315750002423 ferric uptake regulator; Provisional; Region: fur; PRK09462 315750002424 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 315750002425 metal binding site 2 [ion binding]; metal-binding site 315750002426 putative DNA binding helix; other site 315750002427 metal binding site 1 [ion binding]; metal-binding site 315750002428 dimer interface [polypeptide binding]; other site 315750002429 structural Zn2+ binding site [ion binding]; other site 315750002430 Protein of unknown function (DUF2614); Region: DUF2614; cl07936 315750002431 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 315750002432 active site 315750002433 substrate binding site [chemical binding]; other site 315750002434 ATP binding site [chemical binding]; other site 315750002435 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 315750002436 catalytic core [active] 315750002437 Bacitracin resistance protein BacA; Region: BacA; cl00858 315750002438 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 315750002439 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; cl01757 315750002440 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 315750002441 Sulfatase; Region: Sulfatase; cl10460 315750002442 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 315750002443 Catalytic site [active] 315750002444 Transposase domain (DUF772); Region: DUF772; pfam05598 315750002445 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 315750002446 DDE superfamily endonuclease; Region: DDE_4; cl15789 315750002447 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 315750002448 NlpC/P60 family; Region: NLPC_P60; cl11438 315750002449 iron-sulfur cluster binding protein, putative; Region: TIGR00276 315750002450 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 315750002451 HEAT repeats; Region: HEAT_2; pfam13646 315750002452 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 315750002453 B3/4 domain; Region: B3_4; cl11458 315750002454 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 315750002455 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 315750002456 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 315750002457 Walker A/P-loop; other site 315750002458 ATP binding site [chemical binding]; other site 315750002459 Q-loop/lid; other site 315750002460 ABC transporter signature motif; other site 315750002461 Walker B; other site 315750002462 D-loop; other site 315750002463 H-loop/switch region; other site 315750002464 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08248 315750002465 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 315750002466 homodimer interface [polypeptide binding]; other site 315750002467 substrate-cofactor binding pocket; other site 315750002468 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750002469 catalytic residue [active] 315750002470 similar to hypothetical protein 315750002471 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 315750002472 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 315750002473 Uncharacterized conserved protein [Function unknown]; Region: COG2718 315750002474 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 315750002475 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 315750002476 E3 interaction surface; other site 315750002477 lipoyl attachment site [posttranslational modification]; other site 315750002478 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 315750002479 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 315750002480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750002481 putative substrate translocation pore; other site 315750002482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750002483 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 315750002484 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 315750002485 DNA-binding site [nucleotide binding]; DNA binding site 315750002486 RNA-binding motif; other site 315750002487 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 315750002488 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 315750002489 metal binding site [ion binding]; metal-binding site 315750002490 active site 315750002491 I-site; other site 315750002492 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 315750002493 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 315750002494 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 315750002495 Coat F domain; Region: Coat_F; cl15836 315750002496 CheB methylesterase; Region: CheB_methylest; pfam01339 315750002497 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 315750002498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 315750002499 PAS domain; Region: PAS_10; pfam13596 315750002500 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 315750002501 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315750002502 putative active site [active] 315750002503 heme pocket [chemical binding]; other site 315750002504 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315750002505 dimer interface [polypeptide binding]; other site 315750002506 phosphorylation site [posttranslational modification] 315750002507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750002508 ATP binding site [chemical binding]; other site 315750002509 Mg2+ binding site [ion binding]; other site 315750002510 G-X-G motif; other site 315750002511 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG4085 315750002512 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 315750002513 generic binding surface II; other site 315750002514 generic binding surface I; other site 315750002515 Staphylococcal nuclease homologues; Region: SNc; smart00318 315750002516 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 315750002517 Catalytic site; other site 315750002518 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 315750002519 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 315750002520 putative active site [active] 315750002521 putative metal binding site [ion binding]; other site 315750002522 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 315750002523 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 315750002524 active site 315750002525 catalytic site [active] 315750002526 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 315750002527 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 315750002528 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 315750002529 active site 315750002530 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 315750002531 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750002532 motif II; other site 315750002533 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750002534 Coenzyme A binding pocket [chemical binding]; other site 315750002535 Predicted amidohydrolase [General function prediction only]; Region: COG0388 315750002536 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 315750002537 putative active site [active] 315750002538 catalytic triad [active] 315750002539 putative dimer interface [polypeptide binding]; other site 315750002540 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 315750002541 Membrane transport protein; Region: Mem_trans; cl09117 315750002542 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 315750002543 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 315750002544 Helix-turn-helix domains; Region: HTH; cl00088 315750002545 aminotransferase; Validated; Region: PRK07678 315750002546 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315750002547 inhibitor-cofactor binding pocket; inhibition site 315750002548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750002549 catalytic residue [active] 315750002550 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 315750002551 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 315750002552 amphipathic channel; other site 315750002553 Asn-Pro-Ala signature motifs; other site 315750002554 glycerol kinase; Provisional; Region: glpK; PRK00047 315750002555 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 315750002556 N- and C-terminal domain interface [polypeptide binding]; other site 315750002557 active site 315750002558 MgATP binding site [chemical binding]; other site 315750002559 catalytic site [active] 315750002560 metal binding site [ion binding]; metal-binding site 315750002561 glycerol binding site [chemical binding]; other site 315750002562 homotetramer interface [polypeptide binding]; other site 315750002563 homodimer interface [polypeptide binding]; other site 315750002564 FBP binding site [chemical binding]; other site 315750002565 protein IIAGlc interface [polypeptide binding]; other site 315750002566 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 315750002567 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 315750002568 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 315750002569 active site 315750002570 substrate binding site [chemical binding]; other site 315750002571 metal binding site [ion binding]; metal-binding site 315750002572 GAF domain; Region: GAF_2; pfam13185 315750002573 GAF domain; Region: GAF; cl15785 315750002574 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 315750002575 Histidine kinase; Region: HisKA_3; pfam07730 315750002576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750002577 ATP binding site [chemical binding]; other site 315750002578 Mg2+ binding site [ion binding]; other site 315750002579 G-X-G motif; other site 315750002580 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 315750002581 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750002582 active site 315750002583 phosphorylation site [posttranslational modification] 315750002584 intermolecular recognition site; other site 315750002585 dimerization interface [polypeptide binding]; other site 315750002586 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 315750002587 DNA binding residues [nucleotide binding] 315750002588 dimerization interface [polypeptide binding]; other site 315750002589 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315750002590 YhdB-like protein; Region: YhdB; pfam14148 315750002591 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 315750002592 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 315750002593 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 315750002594 tetramer interface [polypeptide binding]; other site 315750002595 heme binding pocket [chemical binding]; other site 315750002596 Helix-turn-helix domains; Region: HTH; cl00088 315750002597 Rrf2 family protein; Region: rrf2_super; TIGR00738 315750002598 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 315750002599 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 315750002600 heme-binding site [chemical binding]; other site 315750002601 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 315750002602 FAD binding pocket [chemical binding]; other site 315750002603 FAD binding motif [chemical binding]; other site 315750002604 phosphate binding motif [ion binding]; other site 315750002605 beta-alpha-beta structure motif; other site 315750002606 NAD binding pocket [chemical binding]; other site 315750002607 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 315750002608 SpoVR like protein; Region: SpoVR; pfam04293 315750002609 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 315750002610 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 315750002611 dimer interface [polypeptide binding]; other site 315750002612 active site 315750002613 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 315750002614 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 315750002615 NlpC/P60 family; Region: NLPC_P60; cl11438 315750002616 Helix-turn-helix domains; Region: HTH; cl00088 315750002617 putative transposase OrfB; Reviewed; Region: PHA02517 315750002618 HTH-like domain; Region: HTH_21; pfam13276 315750002619 Integrase core domain; Region: rve; cl01316 315750002620 Integrase core domain; Region: rve_3; cl15866 315750002621 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 315750002622 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 315750002623 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 315750002624 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315750002625 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315750002626 DNA binding residues [nucleotide binding] 315750002627 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 315750002628 putative acyl-acceptor binding pocket; other site 315750002629 AAA domain; Region: AAA_32; pfam13654 315750002630 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 315750002631 Domain of unknown function DUF21; Region: DUF21; pfam01595 315750002632 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 315750002633 Transporter associated domain; Region: CorC_HlyC; cl08393 315750002634 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 315750002635 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315750002636 DNA binding residues [nucleotide binding] 315750002637 putative dimer interface [polypeptide binding]; other site 315750002638 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 315750002639 Domain of unknown function DUF21; Region: DUF21; pfam01595 315750002640 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 315750002641 Transporter associated domain; Region: CorC_HlyC; cl08393 315750002642 CrcB-like protein; Region: CRCB; cl09114 315750002643 CrcB-like protein; Region: CRCB; cl09114 315750002644 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 315750002645 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 315750002646 active site 315750002647 catalytic site [active] 315750002648 Mechanosensitive ion channel; Region: MS_channel; pfam00924 315750002649 NAD-dependent deacetylase; Provisional; Region: PRK00481 315750002650 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 315750002651 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 315750002652 NodB motif; other site 315750002653 active site 315750002654 catalytic site [active] 315750002655 Zn binding site [ion binding]; other site 315750002656 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 315750002657 homodimer interface [polypeptide binding]; other site 315750002658 substrate-cofactor binding pocket; other site 315750002659 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750002660 catalytic residue [active] 315750002661 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 315750002662 Ligand Binding Site [chemical binding]; other site 315750002663 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 315750002664 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 315750002665 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750002666 Walker A/P-loop; other site 315750002667 ATP binding site [chemical binding]; other site 315750002668 Q-loop/lid; other site 315750002669 ABC transporter signature motif; other site 315750002670 Walker B; other site 315750002671 D-loop; other site 315750002672 H-loop/switch region; other site 315750002673 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 315750002674 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 315750002675 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 315750002676 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 315750002677 Walker A/P-loop; other site 315750002678 ATP binding site [chemical binding]; other site 315750002679 Q-loop/lid; other site 315750002680 ABC transporter signature motif; other site 315750002681 Walker B; other site 315750002682 D-loop; other site 315750002683 H-loop/switch region; other site 315750002684 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 315750002685 NADH(P)-binding; Region: NAD_binding_10; pfam13460 315750002686 NAD binding site [chemical binding]; other site 315750002687 substrate binding site [chemical binding]; other site 315750002688 putative active site [active] 315750002689 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 315750002690 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 315750002691 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 315750002692 Walker A/P-loop; other site 315750002693 ATP binding site [chemical binding]; other site 315750002694 Q-loop/lid; other site 315750002695 ABC transporter signature motif; other site 315750002696 Walker B; other site 315750002697 D-loop; other site 315750002698 H-loop/switch region; other site 315750002699 TOBE domain; Region: TOBE_2; cl01440 315750002700 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 315750002701 Helix-turn-helix domains; Region: HTH; cl00088 315750002702 ATP-grasp domain; Region: ATP-grasp_4; cl03087 315750002703 ATP-grasp domain; Region: ATP-grasp_4; cl03087 315750002704 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 315750002705 Protein of unknown function (DUF964); Region: DUF964; cl01483 315750002706 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750002707 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 315750002708 active site 315750002709 motif I; other site 315750002710 motif II; other site 315750002711 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 315750002712 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315750002713 FeS/SAM binding site; other site 315750002714 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 315750002715 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750002716 enoyl-CoA hydratase; Provisional; Region: PRK07659 315750002717 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 315750002718 substrate binding site [chemical binding]; other site 315750002719 oxyanion hole (OAH) forming residues; other site 315750002720 trimer interface [polypeptide binding]; other site 315750002721 YhzD-like protein; Region: YhzD; pfam14120 315750002722 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 315750002723 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 315750002724 active site 315750002725 metal binding site [ion binding]; metal-binding site 315750002726 DNA binding site [nucleotide binding] 315750002727 Uncharacterized conserved protein [Function unknown]; Region: COG4717 315750002728 Aphid transmission protein; Region: Cauli_AT; pfam03233 315750002729 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 315750002730 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 315750002731 generic binding surface II; other site 315750002732 generic binding surface I; other site 315750002733 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 315750002734 Zn2+ binding site [ion binding]; other site 315750002735 Mg2+ binding site [ion binding]; other site 315750002736 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 315750002737 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 315750002738 PPIC-type PPIASE domain; Region: Rotamase; cl08278 315750002739 similar to hypothetical protein 315750002740 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 315750002741 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 315750002742 transcriptional regulator Hpr; Provisional; Region: PRK13777 315750002743 Helix-turn-helix domains; Region: HTH; cl00088 315750002744 YtxH-like protein; Region: YtxH; cl02079 315750002745 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 315750002746 homodimer interface [polypeptide binding]; other site 315750002747 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 315750002748 substrate-cofactor binding pocket; other site 315750002749 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750002750 catalytic residue [active] 315750002751 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 315750002752 HIT family signature motif; other site 315750002753 catalytic residue [active] 315750002754 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 315750002755 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 315750002756 Walker A/P-loop; other site 315750002757 ATP binding site [chemical binding]; other site 315750002758 Q-loop/lid; other site 315750002759 ABC transporter signature motif; other site 315750002760 Walker B; other site 315750002761 D-loop; other site 315750002762 H-loop/switch region; other site 315750002763 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 315750002764 EcsC protein family; Region: EcsC; pfam12787 315750002765 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 315750002766 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 315750002767 metal binding site [ion binding]; metal-binding site 315750002768 dimer interface [polypeptide binding]; other site 315750002769 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 315750002770 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 315750002771 Transglycosylase; Region: Transgly; cl07896 315750002772 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 315750002773 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315750002774 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 315750002775 substrate binding site [chemical binding]; other site 315750002776 active site 315750002777 ferrochelatase; Provisional; Region: PRK12435 315750002778 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 315750002779 C-terminal domain interface [polypeptide binding]; other site 315750002780 active site 315750002781 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 315750002782 active site 315750002783 N-terminal domain interface [polypeptide binding]; other site 315750002784 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 315750002785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750002786 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750002787 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750002788 Helix-turn-helix domains; Region: HTH; cl00088 315750002789 Predicted membrane protein [Function unknown]; Region: COG1511 315750002790 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 315750002791 ABC-2 type transporter; Region: ABC2_membrane; cl11417 315750002792 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 315750002793 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 315750002794 putative oligomer interface [polypeptide binding]; other site 315750002795 putative active site [active] 315750002796 metal binding site [ion binding]; metal-binding site 315750002797 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 315750002798 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 315750002799 YhfH-like protein; Region: YhfH; pfam14149 315750002800 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315750002801 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 315750002802 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 315750002803 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 315750002804 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 315750002805 AMP-binding enzyme; Region: AMP-binding; cl15778 315750002806 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315750002807 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 315750002808 Peptidase family M48; Region: Peptidase_M48; cl12018 315750002809 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 315750002810 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 315750002811 active site 315750002812 catalytic residues [active] 315750002813 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 315750002814 catalytic core [active] 315750002815 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 315750002816 heme-binding site [chemical binding]; other site 315750002817 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750002818 dimer interface [polypeptide binding]; other site 315750002819 putative CheW interface [polypeptide binding]; other site 315750002820 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750002821 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 315750002822 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 315750002823 [2Fe-2S] cluster binding site [ion binding]; other site 315750002824 short chain dehydrogenase; Provisional; Region: PRK06701 315750002825 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 315750002826 NAD binding site [chemical binding]; other site 315750002827 metal binding site [ion binding]; metal-binding site 315750002828 active site 315750002829 IDEAL domain; Region: IDEAL; cl07452 315750002830 ComK protein; Region: ComK; cl11560 315750002831 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 315750002832 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 315750002833 dimer interface [polypeptide binding]; other site 315750002834 active site 315750002835 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 315750002836 substrate binding site [chemical binding]; other site 315750002837 catalytic residue [active] 315750002838 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 315750002839 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315750002840 DNA-binding site [nucleotide binding]; DNA binding site 315750002841 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315750002842 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750002843 homodimer interface [polypeptide binding]; other site 315750002844 catalytic residue [active] 315750002845 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750002846 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 315750002847 RNAase interaction site [polypeptide binding]; other site 315750002848 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 315750002849 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315750002850 ABC-ATPase subunit interface; other site 315750002851 dimer interface [polypeptide binding]; other site 315750002852 putative PBP binding regions; other site 315750002853 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315750002854 ABC-ATPase subunit interface; other site 315750002855 dimer interface [polypeptide binding]; other site 315750002856 putative PBP binding regions; other site 315750002857 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 315750002858 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 315750002859 Walker A/P-loop; other site 315750002860 ATP binding site [chemical binding]; other site 315750002861 Q-loop/lid; other site 315750002862 ABC transporter signature motif; other site 315750002863 Walker B; other site 315750002864 D-loop; other site 315750002865 H-loop/switch region; other site 315750002866 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 315750002867 putative ligand binding residues [chemical binding]; other site 315750002868 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 315750002869 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 315750002870 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 315750002871 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 315750002872 Putative ammonia monooxygenase; Region: AmoA; pfam05145 315750002873 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 315750002874 Peptidase family M48; Region: Peptidase_M48; cl12018 315750002875 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 315750002876 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 315750002877 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 315750002878 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750002879 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 315750002880 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 315750002881 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 315750002882 active site 315750002883 metal binding site [ion binding]; metal-binding site 315750002884 DNA binding site [nucleotide binding] 315750002885 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 315750002886 exonuclease SbcC; Region: sbcc; TIGR00618 315750002887 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 315750002888 Walker A/P-loop; other site 315750002889 ATP binding site [chemical binding]; other site 315750002890 Q-loop/lid; other site 315750002891 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 315750002892 ABC transporter signature motif; other site 315750002893 Walker B; other site 315750002894 D-loop; other site 315750002895 H-loop/switch region; other site 315750002896 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 315750002897 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 315750002898 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 315750002899 Spore germination protein GerPC; Region: GerPC; pfam10737 315750002900 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 315750002901 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 315750002902 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 315750002903 CotH protein; Region: CotH; pfam08757 315750002904 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 315750002905 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 315750002906 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 315750002907 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 315750002908 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 315750002909 active site 315750002910 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 315750002911 dimer interface [polypeptide binding]; other site 315750002912 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 315750002913 Ligand Binding Site [chemical binding]; other site 315750002914 Molecular Tunnel; other site 315750002915 phytoene desaturase; Region: crtI_fam; TIGR02734 315750002916 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750002917 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 315750002918 active site lid residues [active] 315750002919 substrate binding pocket [chemical binding]; other site 315750002920 catalytic residues [active] 315750002921 substrate-Mg2+ binding site; other site 315750002922 aspartate-rich region 1; other site 315750002923 aspartate-rich region 2; other site 315750002924 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 315750002925 MatE; Region: MatE; cl10513 315750002926 MatE; Region: MatE; cl10513 315750002927 Cupin domain; Region: Cupin_2; cl09118 315750002928 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315750002929 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 315750002930 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315750002931 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315750002932 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315750002933 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315750002934 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 315750002935 trimer interface [polypeptide binding]; other site 315750002936 active site 315750002937 substrate binding site [chemical binding]; other site 315750002938 CoA binding site [chemical binding]; other site 315750002939 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 315750002940 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315750002941 inhibitor-cofactor binding pocket; inhibition site 315750002942 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750002943 catalytic residue [active] 315750002944 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 315750002945 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 315750002946 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750002947 catalytic residue [active] 315750002948 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 315750002949 IucA / IucC family; Region: IucA_IucC; pfam04183 315750002950 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 315750002951 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 315750002952 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 315750002953 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315750002954 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 315750002955 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 315750002956 IucA / IucC family; Region: IucA_IucC; pfam04183 315750002957 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 315750002958 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315750002959 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 315750002960 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 315750002961 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 315750002962 substrate binding pocket [chemical binding]; other site 315750002963 dimer interface [polypeptide binding]; other site 315750002964 inhibitor binding site; inhibition site 315750002965 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 315750002966 B12 binding site [chemical binding]; other site 315750002967 cobalt ligand [ion binding]; other site 315750002968 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 315750002969 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 315750002970 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 315750002971 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 315750002972 FAD binding site [chemical binding]; other site 315750002973 Protein of unknown function (DUF520); Region: DUF520; cl00723 315750002974 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 315750002975 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 315750002976 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 315750002977 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 315750002978 ligand binding site [chemical binding]; other site 315750002979 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 315750002980 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315750002981 dimerization interface [polypeptide binding]; other site 315750002982 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315750002983 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750002984 dimer interface [polypeptide binding]; other site 315750002985 putative CheW interface [polypeptide binding]; other site 315750002986 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 315750002987 Uncharacterized conserved protein [Function unknown]; Region: COG1284 315750002988 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315750002989 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315750002990 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 315750002991 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 315750002992 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 315750002993 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 315750002994 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 315750002995 motif II; other site 315750002996 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 315750002997 esterase; Provisional; Region: PRK10566 315750002998 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315750002999 Domain of unknown function DUF59; Region: DUF59; cl00941 315750003000 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 315750003001 FAD binding domain; Region: FAD_binding_4; pfam01565 315750003002 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 315750003003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750003004 putative substrate translocation pore; other site 315750003005 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 315750003006 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750003007 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 315750003008 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 315750003009 heterotetramer interface [polypeptide binding]; other site 315750003010 active site pocket [active] 315750003011 cleavage site 315750003012 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 315750003013 nucleotide binding site [chemical binding]; other site 315750003014 N-acetyl-L-glutamate binding site [chemical binding]; other site 315750003015 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 315750003016 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315750003017 inhibitor-cofactor binding pocket; inhibition site 315750003018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750003019 catalytic residue [active] 315750003020 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 315750003021 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 315750003022 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 315750003023 catalytic site [active] 315750003024 subunit interface [polypeptide binding]; other site 315750003025 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 315750003026 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 315750003027 ATP-grasp domain; Region: ATP-grasp_4; cl03087 315750003028 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 315750003029 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 315750003030 ATP-grasp domain; Region: ATP-grasp_4; cl03087 315750003031 ornithine carbamoyltransferase; Provisional; Region: PRK00779 315750003032 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 315750003033 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750003034 YjzC-like protein; Region: YjzC; pfam14168 315750003035 H+ Antiporter protein; Region: 2A0121; TIGR00900 315750003036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750003037 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 315750003038 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 315750003039 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 315750003040 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 315750003041 putative ligand binding site [chemical binding]; other site 315750003042 ComZ; Region: ComZ; pfam10815 315750003043 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 315750003044 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 315750003045 dimer interface [polypeptide binding]; other site 315750003046 active site 315750003047 CoA binding pocket [chemical binding]; other site 315750003048 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 315750003049 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 315750003050 dimer interface [polypeptide binding]; other site 315750003051 active site 315750003052 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 315750003053 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 315750003054 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 315750003055 Walker A/P-loop; other site 315750003056 ATP binding site [chemical binding]; other site 315750003057 Q-loop/lid; other site 315750003058 ABC transporter signature motif; other site 315750003059 Walker B; other site 315750003060 D-loop; other site 315750003061 H-loop/switch region; other site 315750003062 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 315750003063 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 315750003064 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 315750003065 Walker A/P-loop; other site 315750003066 ATP binding site [chemical binding]; other site 315750003067 Q-loop/lid; other site 315750003068 ABC transporter signature motif; other site 315750003069 Walker B; other site 315750003070 D-loop; other site 315750003071 H-loop/switch region; other site 315750003072 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 315750003073 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 315750003074 peptide binding site [polypeptide binding]; other site 315750003075 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 315750003076 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 315750003077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750003078 dimer interface [polypeptide binding]; other site 315750003079 conserved gate region; other site 315750003080 putative PBP binding loops; other site 315750003081 ABC-ATPase subunit interface; other site 315750003082 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 315750003083 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 315750003084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750003085 dimer interface [polypeptide binding]; other site 315750003086 conserved gate region; other site 315750003087 putative PBP binding loops; other site 315750003088 ABC-ATPase subunit interface; other site 315750003089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750003090 S-adenosylmethionine binding site [chemical binding]; other site 315750003091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750003092 H+ Antiporter protein; Region: 2A0121; TIGR00900 315750003093 putative substrate translocation pore; other site 315750003094 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 315750003095 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 315750003096 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 315750003097 active site 315750003098 HIGH motif; other site 315750003099 dimer interface [polypeptide binding]; other site 315750003100 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 315750003101 KMSKS motif; other site 315750003102 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 315750003103 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 315750003104 peptide binding site [polypeptide binding]; other site 315750003105 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 315750003106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750003107 dimer interface [polypeptide binding]; other site 315750003108 conserved gate region; other site 315750003109 putative PBP binding loops; other site 315750003110 ABC-ATPase subunit interface; other site 315750003111 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 315750003112 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 315750003113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750003114 dimer interface [polypeptide binding]; other site 315750003115 conserved gate region; other site 315750003116 putative PBP binding loops; other site 315750003117 ABC-ATPase subunit interface; other site 315750003118 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 315750003119 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 315750003120 Walker A/P-loop; other site 315750003121 ATP binding site [chemical binding]; other site 315750003122 Q-loop/lid; other site 315750003123 ABC transporter signature motif; other site 315750003124 Walker B; other site 315750003125 D-loop; other site 315750003126 H-loop/switch region; other site 315750003127 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 315750003128 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 315750003129 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 315750003130 Walker A/P-loop; other site 315750003131 ATP binding site [chemical binding]; other site 315750003132 Q-loop/lid; other site 315750003133 ABC transporter signature motif; other site 315750003134 Walker B; other site 315750003135 D-loop; other site 315750003136 H-loop/switch region; other site 315750003137 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 315750003138 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 315750003139 ArsC family; Region: ArsC; pfam03960 315750003140 putative catalytic residues [active] 315750003141 thiol/disulfide switch; other site 315750003142 Integral membrane protein TerC family; Region: TerC; cl10468 315750003143 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 315750003144 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 315750003145 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 315750003146 putative active site [active] 315750003147 catalytic site [active] 315750003148 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 315750003149 putative active site [active] 315750003150 catalytic site [active] 315750003151 Competence protein CoiA-like family; Region: CoiA; cl11541 315750003152 oligoendopeptidase F; Region: pepF; TIGR00181 315750003153 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 315750003154 active site 315750003155 Zn binding site [ion binding]; other site 315750003156 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 315750003157 Thioredoxin; Region: Thioredoxin_5; pfam13743 315750003158 catalytic residues [active] 315750003159 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 315750003160 apolar tunnel; other site 315750003161 heme binding site [chemical binding]; other site 315750003162 dimerization interface [polypeptide binding]; other site 315750003163 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 315750003164 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 315750003165 N-acetyl-D-glucosamine binding site [chemical binding]; other site 315750003166 catalytic residue [active] 315750003167 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 315750003168 putative active site [active] 315750003169 putative metal binding residues [ion binding]; other site 315750003170 signature motif; other site 315750003171 putative triphosphate binding site [ion binding]; other site 315750003172 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 315750003173 synthetase active site [active] 315750003174 NTP binding site [chemical binding]; other site 315750003175 metal binding site [ion binding]; metal-binding site 315750003176 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 315750003177 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 315750003178 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 315750003179 active site 315750003180 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 315750003181 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 315750003182 active site 315750003183 metal binding site [ion binding]; metal-binding site 315750003184 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 315750003185 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 315750003186 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 315750003187 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750003188 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 315750003189 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 315750003190 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 315750003191 thiamine phosphate binding site [chemical binding]; other site 315750003192 active site 315750003193 pyrophosphate binding site [ion binding]; other site 315750003194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750003195 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 315750003196 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 315750003197 thiS-thiF/thiG interaction site; other site 315750003198 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 315750003199 ThiS interaction site; other site 315750003200 putative active site [active] 315750003201 tetramer interface [polypeptide binding]; other site 315750003202 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 315750003203 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 315750003204 ATP binding site [chemical binding]; other site 315750003205 substrate interface [chemical binding]; other site 315750003206 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 315750003207 dimer interface [polypeptide binding]; other site 315750003208 substrate binding site [chemical binding]; other site 315750003209 ATP binding site [chemical binding]; other site 315750003210 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 315750003211 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 315750003212 NAD binding site [chemical binding]; other site 315750003213 homotetramer interface [polypeptide binding]; other site 315750003214 homodimer interface [polypeptide binding]; other site 315750003215 substrate binding site [chemical binding]; other site 315750003216 active site 315750003217 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 315750003218 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 315750003219 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 315750003220 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 315750003221 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 315750003222 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 315750003223 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 315750003224 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 315750003225 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 315750003226 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750003227 Family description; Region: UvrD_C_2; cl15862 315750003228 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750003229 Coenzyme A binding pocket [chemical binding]; other site 315750003230 hypothetical protein; Provisional; Region: PRK13679 315750003231 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 315750003232 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315750003233 Putative esterase; Region: Esterase; pfam00756 315750003234 cystathionine gamma-synthase; Reviewed; Region: PRK08247 315750003235 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 315750003236 homodimer interface [polypeptide binding]; other site 315750003237 substrate-cofactor binding pocket; other site 315750003238 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750003239 catalytic residue [active] 315750003240 cystathionine beta-lyase; Provisional; Region: PRK08064 315750003241 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 315750003242 homodimer interface [polypeptide binding]; other site 315750003243 substrate-cofactor binding pocket; other site 315750003244 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750003245 catalytic residue [active] 315750003246 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 315750003247 Helix-turn-helix domains; Region: HTH; cl00088 315750003248 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 315750003249 homotrimer interaction site [polypeptide binding]; other site 315750003250 putative active site [active] 315750003251 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 315750003252 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 315750003253 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315750003254 Helix-turn-helix domains; Region: HTH; cl00088 315750003255 Domain of unknown function (DUF303); Region: DUF303; pfam03629 315750003256 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 315750003257 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 315750003258 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315750003259 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315750003260 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 315750003261 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 315750003262 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 315750003263 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315750003264 Helix-turn-helix domains; Region: HTH; cl00088 315750003265 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315750003266 dimerization interface [polypeptide binding]; other site 315750003267 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 315750003268 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315750003269 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315750003270 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315750003271 Helix-turn-helix domains; Region: HTH; cl00088 315750003272 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315750003273 dimerization interface [polypeptide binding]; other site 315750003274 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 315750003275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750003276 putative substrate translocation pore; other site 315750003277 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 315750003278 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750003279 Coenzyme A binding pocket [chemical binding]; other site 315750003280 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750003281 binding surface 315750003282 TPR motif; other site 315750003283 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 315750003284 alanine racemase; Region: alr; TIGR00492 315750003285 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 315750003286 active site 315750003287 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 315750003288 dimer interface [polypeptide binding]; other site 315750003289 substrate binding site [chemical binding]; other site 315750003290 catalytic residues [active] 315750003291 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 315750003292 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 315750003293 catalytic Zn binding site [ion binding]; other site 315750003294 NAD binding site [chemical binding]; other site 315750003295 structural Zn binding site [ion binding]; other site 315750003296 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750003297 Helix-turn-helix domains; Region: HTH; cl00088 315750003298 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 315750003299 flagellin; Provisional; Region: PRK12804 315750003300 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 315750003301 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 315750003302 flagellin; Provisional; Region: PRK12804 315750003303 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 315750003304 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 315750003305 flagellin; Provisional; Region: PRK12804 315750003306 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 315750003307 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 315750003308 flagellin; Provisional; Region: PRK12804 315750003309 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 315750003310 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 315750003311 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 315750003312 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750003313 dimer interface [polypeptide binding]; other site 315750003314 putative CheW interface [polypeptide binding]; other site 315750003315 Protein of unknown function (DUF867); Region: DUF867; cl01713 315750003316 Domain of unknown function (DUF955); Region: DUF955; cl01076 315750003317 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 315750003318 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 315750003319 amidase catalytic site [active] 315750003320 Zn binding residues [ion binding]; other site 315750003321 substrate binding site [chemical binding]; other site 315750003322 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 315750003323 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 315750003324 Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185 315750003325 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 315750003326 Phosphate transporter family; Region: PHO4; cl00396 315750003327 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 315750003328 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 315750003329 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 315750003330 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 315750003331 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 315750003332 active site 315750003333 phosphorylation site [posttranslational modification] 315750003334 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 315750003335 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 315750003336 active site 315750003337 P-loop; other site 315750003338 phosphorylation site [posttranslational modification] 315750003339 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 315750003340 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 315750003341 putative NAD(P) binding site [chemical binding]; other site 315750003342 catalytic Zn binding site [ion binding]; other site 315750003343 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 315750003344 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 315750003345 tetramer interface [polypeptide binding]; other site 315750003346 TPP-binding site [chemical binding]; other site 315750003347 heterodimer interface [polypeptide binding]; other site 315750003348 phosphorylation loop region [posttranslational modification] 315750003349 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 315750003350 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 315750003351 alpha subunit interface [polypeptide binding]; other site 315750003352 TPP binding site [chemical binding]; other site 315750003353 heterodimer interface [polypeptide binding]; other site 315750003354 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 315750003355 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 315750003356 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 315750003357 E3 interaction surface; other site 315750003358 lipoyl attachment site [posttranslational modification]; other site 315750003359 e3 binding domain; Region: E3_binding; pfam02817 315750003360 e3 binding domain; Region: E3_binding; pfam02817 315750003361 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 315750003362 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 315750003363 glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Region: glycerol3P_GlpB; TIGR03378 315750003364 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315750003365 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 315750003366 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750003367 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 315750003368 NAD(P) binding site [chemical binding]; other site 315750003369 active site 315750003370 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 315750003371 classical (c) SDRs; Region: SDR_c; cd05233 315750003372 NAD(P) binding site [chemical binding]; other site 315750003373 active site 315750003374 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 315750003375 Helix-turn-helix domains; Region: HTH; cl00088 315750003376 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 315750003377 C3HC zinc finger-like; Region: zf-C3HC; pfam07967 315750003378 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 315750003379 Spore germination protein; Region: Spore_permease; cl15802 315750003380 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 315750003381 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315750003382 Zn binding site [ion binding]; other site 315750003383 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 315750003384 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315750003385 Zn binding site [ion binding]; other site 315750003386 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 315750003387 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 315750003388 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 315750003389 protein binding site [polypeptide binding]; other site 315750003390 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750003391 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 315750003392 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 315750003393 SxDxEG motif; other site 315750003394 active site 315750003395 metal binding site [ion binding]; metal-binding site 315750003396 homopentamer interface [polypeptide binding]; other site 315750003397 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 315750003398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750003399 dimer interface [polypeptide binding]; other site 315750003400 conserved gate region; other site 315750003401 putative PBP binding loops; other site 315750003402 ABC-ATPase subunit interface; other site 315750003403 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 315750003404 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 315750003405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750003406 putative PBP binding loops; other site 315750003407 dimer interface [polypeptide binding]; other site 315750003408 ABC-ATPase subunit interface; other site 315750003409 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 315750003410 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 315750003411 Walker A/P-loop; other site 315750003412 ATP binding site [chemical binding]; other site 315750003413 Q-loop/lid; other site 315750003414 ABC transporter signature motif; other site 315750003415 Walker B; other site 315750003416 D-loop; other site 315750003417 H-loop/switch region; other site 315750003418 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 315750003419 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 315750003420 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 315750003421 peptide binding site [polypeptide binding]; other site 315750003422 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 315750003423 dimer interface [polypeptide binding]; other site 315750003424 catalytic triad [active] 315750003425 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 315750003426 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 315750003427 active site 315750003428 NlpC/P60 family; Region: NLPC_P60; cl11438 315750003429 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 315750003430 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 315750003431 Walker A/P-loop; other site 315750003432 ATP binding site [chemical binding]; other site 315750003433 Q-loop/lid; other site 315750003434 ABC transporter signature motif; other site 315750003435 Walker B; other site 315750003436 D-loop; other site 315750003437 H-loop/switch region; other site 315750003438 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 315750003439 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 315750003440 Amidinotransferase; Region: Amidinotransf; cl12043 315750003441 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 315750003442 Helix-turn-helix domains; Region: HTH; cl00088 315750003443 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315750003444 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 315750003445 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 315750003446 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 315750003447 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 315750003448 DNA binding site [nucleotide binding] 315750003449 active site 315750003450 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 315750003451 possible YkkC-YxkD riboswitch; BPUM_nc0009 315750003452 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 315750003453 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 315750003454 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 315750003455 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 315750003456 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 315750003457 putative active site [active] 315750003458 putative substrate binding site [chemical binding]; other site 315750003459 putative cosubstrate binding site; other site 315750003460 catalytic site [active] 315750003461 gamma-glutamyl kinase; Provisional; Region: PRK05429 315750003462 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 315750003463 nucleotide binding site [chemical binding]; other site 315750003464 homotetrameric interface [polypeptide binding]; other site 315750003465 putative phosphate binding site [ion binding]; other site 315750003466 putative allosteric binding site; other site 315750003467 PUA domain; Region: PUA; cl00607 315750003468 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 315750003469 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 315750003470 putative catalytic cysteine [active] 315750003471 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750003472 TPR motif; other site 315750003473 binding surface 315750003474 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315750003475 OsmC-like protein; Region: OsmC; cl00767 315750003476 Helix-turn-helix domains; Region: HTH; cl00088 315750003477 OsmC-like protein; Region: OsmC; cl00767 315750003478 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 315750003479 nucleoside/Zn binding site; other site 315750003480 dimer interface [polypeptide binding]; other site 315750003481 catalytic motif [active] 315750003482 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 315750003483 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 315750003484 THF binding site; other site 315750003485 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 315750003486 substrate binding site [chemical binding]; other site 315750003487 THF binding site; other site 315750003488 zinc-binding site [ion binding]; other site 315750003489 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 315750003490 active site 315750003491 catalytic residues [active] 315750003492 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315750003493 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750003494 active site 315750003495 phosphorylation site [posttranslational modification] 315750003496 intermolecular recognition site; other site 315750003497 dimerization interface [polypeptide binding]; other site 315750003498 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315750003499 DNA binding site [nucleotide binding] 315750003500 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315750003501 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 315750003502 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315750003503 dimer interface [polypeptide binding]; other site 315750003504 phosphorylation site [posttranslational modification] 315750003505 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750003506 ATP binding site [chemical binding]; other site 315750003507 Mg2+ binding site [ion binding]; other site 315750003508 G-X-G motif; other site 315750003509 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 315750003510 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 315750003511 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 315750003512 YkoK riboswitch; BPUM_nc0010 315750003513 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 315750003514 MgtE intracellular N domain; Region: MgtE_N; cl15244 315750003515 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 315750003516 Divalent cation transporter; Region: MgtE; cl00786 315750003517 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315750003518 Helix-turn-helix domains; Region: HTH; cl00088 315750003519 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 315750003520 dimerization interface [polypeptide binding]; other site 315750003521 Cupin domain; Region: Cupin_2; cl09118 315750003522 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 315750003523 DNA binding residues [nucleotide binding] 315750003524 putative dimer interface [polypeptide binding]; other site 315750003525 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315750003526 Helix-turn-helix domains; Region: HTH; cl00088 315750003527 Helix-turn-helix domains; Region: HTH; cl00088 315750003528 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 315750003529 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 315750003530 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 315750003531 metal binding site [ion binding]; metal-binding site 315750003532 active site 315750003533 I-site; other site 315750003534 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 315750003535 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 315750003536 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 315750003537 YybP-YkoY riboswitch element; SraF riboswitch; BPUM_nc0011 315750003538 Integral membrane protein TerC family; Region: TerC; cl10468 315750003539 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 315750003540 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315750003541 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 315750003542 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 315750003543 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 315750003544 Peptidase family M48; Region: Peptidase_M48; cl12018 315750003545 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 315750003546 Cation transport protein; Region: TrkH; cl10514 315750003547 Protein of unknown function (DUF421); Region: DUF421; cl00990 315750003548 OpgC protein; Region: OpgC_C; cl00792 315750003549 Acyltransferase family; Region: Acyl_transf_3; pfam01757 315750003550 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 315750003551 PAS domain; Region: PAS_9; pfam13426 315750003552 PAS domain S-box; Region: sensory_box; TIGR00229 315750003553 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 315750003554 PAS domain S-box; Region: sensory_box; TIGR00229 315750003555 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 315750003556 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 315750003557 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 315750003558 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315750003559 dimer interface [polypeptide binding]; other site 315750003560 phosphorylation site [posttranslational modification] 315750003561 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750003562 ATP binding site [chemical binding]; other site 315750003563 Mg2+ binding site [ion binding]; other site 315750003564 G-X-G motif; other site 315750003565 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 315750003566 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 315750003567 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 315750003568 DNA binding site [nucleotide binding] 315750003569 active site 315750003570 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 315750003571 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 315750003572 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 315750003573 transaminase; Reviewed; Region: PRK08068 315750003574 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315750003575 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750003576 homodimer interface [polypeptide binding]; other site 315750003577 catalytic residue [active] 315750003578 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 315750003579 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 315750003580 dimer interface [polypeptide binding]; other site 315750003581 active site 315750003582 catalytic residue [active] 315750003583 metal binding site [ion binding]; metal-binding site 315750003584 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 315750003585 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750003586 motif II; other site 315750003587 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 315750003588 intersubunit interface [polypeptide binding]; other site 315750003589 active site 315750003590 Zn2+ binding site [ion binding]; other site 315750003591 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 315750003592 Cupin domain; Region: Cupin_2; cl09118 315750003593 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 315750003594 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315750003595 dimer interface [polypeptide binding]; other site 315750003596 phosphorylation site [posttranslational modification] 315750003597 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750003598 ATP binding site [chemical binding]; other site 315750003599 Mg2+ binding site [ion binding]; other site 315750003600 G-X-G motif; other site 315750003601 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315750003602 Helix-turn-helix domains; Region: HTH; cl00088 315750003603 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 315750003604 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 315750003605 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 315750003606 ligand binding site [chemical binding]; other site 315750003607 flagellar motor protein MotA; Validated; Region: PRK08124 315750003608 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 315750003609 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750003610 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 315750003611 Walker A motif; other site 315750003612 ATP binding site [chemical binding]; other site 315750003613 Walker B motif; other site 315750003614 arginine finger; other site 315750003615 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750003616 Walker A motif; other site 315750003617 ATP binding site [chemical binding]; other site 315750003618 Walker B motif; other site 315750003619 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 315750003620 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 315750003621 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 315750003622 Ligand Binding Site [chemical binding]; other site 315750003623 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 315750003624 active site 315750003625 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 315750003626 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315750003627 FeS/SAM binding site; other site 315750003628 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 315750003629 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315750003630 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750003631 Coenzyme A binding pocket [chemical binding]; other site 315750003632 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 315750003633 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 315750003634 MatE; Region: MatE; cl10513 315750003635 MatE; Region: MatE; cl10513 315750003636 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 315750003637 catalytic residues [active] 315750003638 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 315750003639 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 315750003640 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 315750003641 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 315750003642 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 315750003643 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 315750003644 active site 315750003645 Transcriptional regulators [Transcription]; Region: PurR; COG1609 315750003646 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315750003647 DNA binding site [nucleotide binding] 315750003648 domain linker motif; other site 315750003649 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 315750003650 putative dimerization interface [polypeptide binding]; other site 315750003651 putative ligand binding site [chemical binding]; other site 315750003652 CAT RNA binding domain; Region: CAT_RBD; cl03904 315750003653 transcriptional antiterminator BglG; Provisional; Region: PRK09772 315750003654 PRD domain; Region: PRD; cl15445 315750003655 PRD domain; Region: PRD; cl15445 315750003656 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 315750003657 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 315750003658 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 315750003659 active site turn [active] 315750003660 phosphorylation site [posttranslational modification] 315750003661 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 315750003662 HPr interaction site; other site 315750003663 glycerol kinase (GK) interaction site [polypeptide binding]; other site 315750003664 active site 315750003665 phosphorylation site [posttranslational modification] 315750003666 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 315750003667 dimerization domain swap beta strand [polypeptide binding]; other site 315750003668 regulatory protein interface [polypeptide binding]; other site 315750003669 active site 315750003670 regulatory phosphorylation site [posttranslational modification]; other site 315750003671 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 315750003672 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 315750003673 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 315750003674 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 315750003675 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 315750003676 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 315750003677 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315750003678 FeS/SAM binding site; other site 315750003679 Cache domain; Region: Cache_1; pfam02743 315750003680 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315750003681 dimerization interface [polypeptide binding]; other site 315750003682 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315750003683 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750003684 dimer interface [polypeptide binding]; other site 315750003685 putative CheW interface [polypeptide binding]; other site 315750003686 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 315750003687 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 315750003688 putative NAD(P) binding site [chemical binding]; other site 315750003689 putative active site [active] 315750003690 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 315750003691 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750003692 Transposase domain (DUF772); Region: DUF772; pfam05598 315750003693 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 315750003694 DDE superfamily endonuclease; Region: DDE_4; cl15789 315750003695 PCI domain; Region: PCI; cl02111 315750003696 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 315750003697 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315750003698 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315750003699 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315750003700 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 315750003701 PAS fold; Region: PAS; pfam00989 315750003702 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315750003703 putative active site [active] 315750003704 heme pocket [chemical binding]; other site 315750003705 PAS fold; Region: PAS; pfam00989 315750003706 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 315750003707 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 315750003708 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315750003709 dimer interface [polypeptide binding]; other site 315750003710 phosphorylation site [posttranslational modification] 315750003711 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750003712 ATP binding site [chemical binding]; other site 315750003713 Mg2+ binding site [ion binding]; other site 315750003714 G-X-G motif; other site 315750003715 aminotransferase A; Validated; Region: PRK07683 315750003716 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315750003717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750003718 homodimer interface [polypeptide binding]; other site 315750003719 catalytic residue [active] 315750003720 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 315750003721 Cation efflux family; Region: Cation_efflux; cl00316 315750003722 RDD family; Region: RDD; cl00746 315750003723 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 315750003724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750003725 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 315750003726 putative CheA interaction surface; other site 315750003727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 315750003728 Response regulator receiver domain; Region: Response_reg; pfam00072 315750003729 YkyB-like protein; Region: YkyB; pfam14177 315750003730 H+ Antiporter protein; Region: 2A0121; TIGR00900 315750003731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750003732 putative substrate translocation pore; other site 315750003733 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 315750003734 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 315750003735 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 315750003736 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 315750003737 putative active site [active] 315750003738 putative metal binding site [ion binding]; other site 315750003739 short chain dehydrogenase; Provisional; Region: PRK07677 315750003740 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 315750003741 NAD(P) binding site [chemical binding]; other site 315750003742 substrate binding site [chemical binding]; other site 315750003743 homotetramer interface [polypeptide binding]; other site 315750003744 active site 315750003745 homodimer interface [polypeptide binding]; other site 315750003746 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 315750003747 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 315750003748 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 315750003749 dimanganese center [ion binding]; other site 315750003750 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 315750003751 Protein of unknown function (DUF458); Region: DUF458; cl00861 315750003752 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 315750003753 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 315750003754 FOG: CBS domain [General function prediction only]; Region: COG0517 315750003755 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315750003756 Helix-turn-helix domains; Region: HTH; cl00088 315750003757 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315750003758 dimerization interface [polypeptide binding]; other site 315750003759 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 315750003760 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 315750003761 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 315750003762 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 315750003763 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 315750003764 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 315750003765 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 315750003766 active site 315750003767 trimer interface [polypeptide binding]; other site 315750003768 substrate binding site [chemical binding]; other site 315750003769 CoA binding site [chemical binding]; other site 315750003770 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 315750003771 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 315750003772 metal binding site [ion binding]; metal-binding site 315750003773 putative dimer interface [polypeptide binding]; other site 315750003774 Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214 315750003775 Mechanosensitive ion channel; Region: MS_channel; pfam00924 315750003776 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 315750003777 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 315750003778 dimer interface [polypeptide binding]; other site 315750003779 decamer (pentamer of dimers) interface [polypeptide binding]; other site 315750003780 catalytic triad [active] 315750003781 peroxidatic and resolving cysteines [active] 315750003782 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 315750003783 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 315750003784 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; cl01353 315750003785 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 315750003786 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 315750003787 GTP binding site; other site 315750003788 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 315750003789 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 315750003790 ATP binding site [chemical binding]; other site 315750003791 substrate interface [chemical binding]; other site 315750003792 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 315750003793 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 315750003794 dimer interface [polypeptide binding]; other site 315750003795 putative functional site; other site 315750003796 putative MPT binding site; other site 315750003797 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750003798 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 315750003799 MoaE homodimer interface [polypeptide binding]; other site 315750003800 MoaD interaction [polypeptide binding]; other site 315750003801 active site residues [active] 315750003802 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 315750003803 MoaE interaction surface [polypeptide binding]; other site 315750003804 MoeB interaction surface [polypeptide binding]; other site 315750003805 thiocarboxylated glycine; other site 315750003806 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 315750003807 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 315750003808 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315750003809 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 315750003810 Walker A/P-loop; other site 315750003811 ATP binding site [chemical binding]; other site 315750003812 Q-loop/lid; other site 315750003813 ABC transporter signature motif; other site 315750003814 Walker B; other site 315750003815 D-loop; other site 315750003816 H-loop/switch region; other site 315750003817 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 315750003818 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 315750003819 FtsX-like permease family; Region: FtsX; cl15850 315750003820 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 315750003821 Helix-turn-helix domains; Region: HTH; cl00088 315750003822 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 315750003823 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 315750003824 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 315750003825 putative substrate binding site [chemical binding]; other site 315750003826 putative ATP binding site [chemical binding]; other site 315750003827 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 315750003828 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 315750003829 active site 315750003830 phosphorylation site [posttranslational modification] 315750003831 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 315750003832 active site 315750003833 P-loop; other site 315750003834 phosphorylation site [posttranslational modification] 315750003835 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 315750003836 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 315750003837 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 315750003838 Catalytic site [active] 315750003839 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 315750003840 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 315750003841 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 315750003842 ABC transporter; Region: ABC_tran_2; pfam12848 315750003843 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 315750003844 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 315750003845 rod-share determining protein MreBH; Provisional; Region: PRK13929 315750003846 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 315750003847 ATP binding site [chemical binding]; other site 315750003848 profilin binding site; other site 315750003849 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 315750003850 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 315750003851 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315750003852 putative active site [active] 315750003853 heme pocket [chemical binding]; other site 315750003854 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315750003855 dimer interface [polypeptide binding]; other site 315750003856 phosphorylation site [posttranslational modification] 315750003857 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750003858 ATP binding site [chemical binding]; other site 315750003859 Mg2+ binding site [ion binding]; other site 315750003860 G-X-G motif; other site 315750003861 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 315750003862 putative active site pocket [active] 315750003863 dimerization interface [polypeptide binding]; other site 315750003864 putative catalytic residue [active] 315750003865 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 315750003866 putative active site pocket [active] 315750003867 dimerization interface [polypeptide binding]; other site 315750003868 putative catalytic residue [active] 315750003869 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 315750003870 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750003871 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 315750003872 adenine deaminase; Region: ade; TIGR01178 315750003873 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 315750003874 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 315750003875 active site 315750003876 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 315750003877 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 315750003878 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315750003879 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 315750003880 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 315750003881 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750003882 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 315750003883 active site 315750003884 motif I; other site 315750003885 motif II; other site 315750003886 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 315750003887 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 315750003888 active site 315750003889 catalytic residues [active] 315750003890 metal binding site [ion binding]; metal-binding site 315750003891 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 315750003892 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 315750003893 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 315750003894 TPP-binding site [chemical binding]; other site 315750003895 tetramer interface [polypeptide binding]; other site 315750003896 heterodimer interface [polypeptide binding]; other site 315750003897 phosphorylation loop region [posttranslational modification] 315750003898 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 315750003899 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 315750003900 alpha subunit interface [polypeptide binding]; other site 315750003901 TPP binding site [chemical binding]; other site 315750003902 heterodimer interface [polypeptide binding]; other site 315750003903 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 315750003904 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 315750003905 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 315750003906 E3 interaction surface; other site 315750003907 lipoyl attachment site [posttranslational modification]; other site 315750003908 e3 binding domain; Region: E3_binding; pfam02817 315750003909 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 315750003910 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 315750003911 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750003912 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315750003913 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 315750003914 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 315750003915 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 315750003916 homodimer interface [polypeptide binding]; other site 315750003917 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750003918 catalytic residue [active] 315750003919 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 315750003920 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 315750003921 Protein of unknown function (DUF1054); Region: DUF1054; cl11544 315750003922 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 315750003923 active site 315750003924 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 315750003925 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 315750003926 G1 box; other site 315750003927 putative GEF interaction site [polypeptide binding]; other site 315750003928 GTP/Mg2+ binding site [chemical binding]; other site 315750003929 Switch I region; other site 315750003930 G2 box; other site 315750003931 G3 box; other site 315750003932 Switch II region; other site 315750003933 G4 box; other site 315750003934 G5 box; other site 315750003935 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 315750003936 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 315750003937 YlaH-like protein; Region: YlaH; pfam14036 315750003938 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; cl11558 315750003939 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 315750003940 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 315750003941 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 315750003942 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 315750003943 putative active site [active] 315750003944 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750003945 Glutaminase; Region: Glutaminase; cl00907 315750003946 Protein of unknown function (DUF1507); Region: DUF1507; cl11487 315750003947 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 315750003948 pyruvate carboxylase; Reviewed; Region: PRK12999 315750003949 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 315750003950 ATP-grasp domain; Region: ATP-grasp_4; cl03087 315750003951 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 315750003952 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 315750003953 active site 315750003954 catalytic residues [active] 315750003955 metal binding site [ion binding]; metal-binding site 315750003956 homodimer binding site [polypeptide binding]; other site 315750003957 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 315750003958 carboxyltransferase (CT) interaction site; other site 315750003959 biotinylation site [posttranslational modification]; other site 315750003960 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 315750003961 DNA photolyase; Region: DNA_photolyase; pfam00875 315750003962 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 315750003963 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 315750003964 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 315750003965 UbiA prenyltransferase family; Region: UbiA; cl00337 315750003966 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 315750003967 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 315750003968 Cytochrome c; Region: Cytochrom_C; cl11414 315750003969 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 315750003970 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 315750003971 D-pathway; other site 315750003972 Putative ubiquinol binding site [chemical binding]; other site 315750003973 Low-spin heme (heme b) binding site [chemical binding]; other site 315750003974 Putative water exit pathway; other site 315750003975 Binuclear center (heme o3/CuB) [ion binding]; other site 315750003976 K-pathway; other site 315750003977 Putative proton exit pathway; other site 315750003978 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 315750003979 Subunit I/III interface [polypeptide binding]; other site 315750003980 Subunit III/IV interface [polypeptide binding]; other site 315750003981 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 315750003982 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 315750003983 YugN-like family; Region: YugN; pfam08868 315750003984 FOG: CBS domain [General function prediction only]; Region: COG0517 315750003985 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 315750003986 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 315750003987 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 315750003988 Putative coat protein; Region: YlbD_coat; pfam14071 315750003989 YlbE-like protein; Region: YlbE; pfam14003 315750003990 Protein of unknown function (DUF964); Region: DUF964; cl01483 315750003991 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 315750003992 BPUM_nc0013; possible ylbH leader 315750003993 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750003994 S-adenosylmethionine binding site [chemical binding]; other site 315750003995 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 315750003996 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 315750003997 active site 315750003998 (T/H)XGH motif; other site 315750003999 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 315750004000 Nucleoside recognition; Region: Gate; cl00486 315750004001 Nucleoside recognition; Region: Gate; cl00486 315750004002 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 315750004003 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 315750004004 active site 315750004005 nucleophile elbow; other site 315750004006 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 315750004007 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 315750004008 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 315750004009 protein binding site [polypeptide binding]; other site 315750004010 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 315750004011 hypothetical protein; Provisional; Region: PRK13670 315750004012 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 315750004013 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 315750004014 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 315750004015 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 315750004016 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 315750004017 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315750004018 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 315750004019 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750004020 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 315750004021 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 315750004022 MraZ protein; Region: MraZ; pfam02381 315750004023 MraZ protein; Region: MraZ; pfam02381 315750004024 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 315750004025 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 315750004026 Septum formation initiator; Region: DivIC; cl11433 315750004027 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 315750004028 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315750004029 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315750004030 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 315750004031 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 315750004032 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 315750004033 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315750004034 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315750004035 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 315750004036 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 315750004037 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 315750004038 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 315750004039 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 315750004040 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 315750004041 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 315750004042 Mg++ binding site [ion binding]; other site 315750004043 putative catalytic motif [active] 315750004044 putative substrate binding site [chemical binding]; other site 315750004045 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 315750004046 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 315750004047 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 315750004048 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 315750004049 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 315750004050 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 315750004051 active site 315750004052 homodimer interface [polypeptide binding]; other site 315750004053 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 315750004054 FAD binding domain; Region: FAD_binding_4; pfam01565 315750004055 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 315750004056 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 315750004057 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 315750004058 Cell division protein FtsQ; Region: FtsQ; pfam03799 315750004059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 315750004060 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 315750004061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 315750004062 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 315750004063 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 315750004064 cell division protein FtsA; Region: ftsA; TIGR01174 315750004065 Cell division protein FtsA; Region: FtsA; cl11496 315750004066 Cell division protein FtsA; Region: FtsA; cl11496 315750004067 cell division protein FtsZ; Validated; Region: PRK09330 315750004068 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 315750004069 nucleotide binding site [chemical binding]; other site 315750004070 SulA interaction site; other site 315750004071 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 315750004072 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 315750004073 active site 315750004074 catalytic triad [active] 315750004075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 315750004076 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315750004077 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315750004078 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 315750004079 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 315750004080 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 315750004081 sporulation sigma factor SigE; Reviewed; Region: PRK08301 315750004082 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315750004083 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315750004084 DNA binding residues [nucleotide binding] 315750004085 sporulation sigma factor SigG; Reviewed; Region: PRK08215 315750004086 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315750004087 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 315750004088 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315750004089 DNA binding residues [nucleotide binding] 315750004090 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 315750004091 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315750004092 putative DNA binding site [nucleotide binding]; other site 315750004093 putative Zn2+ binding site [ion binding]; other site 315750004094 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 315750004095 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 315750004096 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750004097 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 315750004098 Glucitol operon activator protein (GutM); Region: GutM; cl01890 315750004099 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 315750004100 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 315750004101 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 315750004102 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 315750004103 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 315750004104 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 315750004105 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 315750004106 Walker A/P-loop; other site 315750004107 ATP binding site [chemical binding]; other site 315750004108 Q-loop/lid; other site 315750004109 ABC transporter signature motif; other site 315750004110 Walker B; other site 315750004111 D-loop; other site 315750004112 H-loop/switch region; other site 315750004113 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 315750004114 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 315750004115 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 315750004116 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 315750004117 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 315750004118 catalytic residue [active] 315750004119 Protein of unknown function (DUF552); Region: DUF552; cl00775 315750004120 YGGT family; Region: YGGT; cl00508 315750004121 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 315750004122 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315750004123 RNA binding surface [nucleotide binding]; other site 315750004124 DivIVA protein; Region: DivIVA; pfam05103 315750004125 DivIVA domain; Region: DivI1A_domain; TIGR03544 315750004126 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 315750004127 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 315750004128 HIGH motif; other site 315750004129 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 315750004130 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 315750004131 active site 315750004132 KMSKS motif; other site 315750004133 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 315750004134 tRNA binding surface [nucleotide binding]; other site 315750004135 anticodon binding site; other site 315750004136 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 315750004137 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 315750004138 lipoprotein signal peptidase; Provisional; Region: PRK14787 315750004139 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 315750004140 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315750004141 RNA binding surface [nucleotide binding]; other site 315750004142 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 315750004143 active site 315750004144 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315750004145 active site 315750004146 uracil transporter; Provisional; Region: PRK10720 315750004147 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 315750004148 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 315750004149 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750004150 dihydroorotase; Validated; Region: pyrC; PRK09357 315750004151 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 315750004152 active site 315750004153 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 315750004154 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 315750004155 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 315750004156 catalytic site [active] 315750004157 subunit interface [polypeptide binding]; other site 315750004158 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 315750004159 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 315750004160 ATP-grasp domain; Region: ATP-grasp_4; cl03087 315750004161 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 315750004162 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 315750004163 ATP-grasp domain; Region: ATP-grasp_4; cl03087 315750004164 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 315750004165 IMP binding site; other site 315750004166 dimer interface [polypeptide binding]; other site 315750004167 interdomain contacts; other site 315750004168 partial ornithine binding site; other site 315750004169 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 315750004170 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 315750004171 FAD binding pocket [chemical binding]; other site 315750004172 FAD binding motif [chemical binding]; other site 315750004173 phosphate binding motif [ion binding]; other site 315750004174 beta-alpha-beta structure motif; other site 315750004175 NAD binding pocket [chemical binding]; other site 315750004176 Iron coordination center [ion binding]; other site 315750004177 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 315750004178 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 315750004179 heterodimer interface [polypeptide binding]; other site 315750004180 active site 315750004181 FMN binding site [chemical binding]; other site 315750004182 homodimer interface [polypeptide binding]; other site 315750004183 substrate binding site [chemical binding]; other site 315750004184 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 315750004185 active site 315750004186 dimer interface [polypeptide binding]; other site 315750004187 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315750004188 active site 315750004189 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 315750004190 Active Sites [active] 315750004191 Phosphate transporter family; Region: PHO4; cl00396 315750004192 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 315750004193 ATP-sulfurylase; Region: ATPS; cd00517 315750004194 active site 315750004195 HXXH motif; other site 315750004196 flexible loop; other site 315750004197 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 315750004198 AAA domain; Region: AAA_18; pfam13238 315750004199 ligand-binding site [chemical binding]; other site 315750004200 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 315750004201 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 315750004202 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 315750004203 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 315750004204 putative active site [active] 315750004205 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 315750004206 putative active site [active] 315750004207 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750004208 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 315750004209 Domain of unknown function (DUF814); Region: DUF814; pfam05670 315750004210 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 315750004211 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 315750004212 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 315750004213 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 315750004214 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 315750004215 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 315750004216 hypothetical protein; Provisional; Region: PRK11820 315750004217 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 315750004218 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 315750004219 Domain of unknown function (DUF370); Region: DUF370; cl00898 315750004220 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 315750004221 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 315750004222 catalytic site [active] 315750004223 G-X2-G-X-G-K; other site 315750004224 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 315750004225 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 315750004226 Flavoprotein; Region: Flavoprotein; cl08021 315750004227 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 315750004228 primosome assembly protein PriA; Validated; Region: PRK05580 315750004229 primosome assembly protein PriA; Validated; Region: PRK05580 315750004230 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315750004231 ATP binding site [chemical binding]; other site 315750004232 putative Mg++ binding site [ion binding]; other site 315750004233 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315750004234 nucleotide binding region [chemical binding]; other site 315750004235 ATP-binding site [chemical binding]; other site 315750004236 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 315750004237 active site 315750004238 catalytic residues [active] 315750004239 metal binding site [ion binding]; metal-binding site 315750004240 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 315750004241 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 315750004242 putative active site [active] 315750004243 substrate binding site [chemical binding]; other site 315750004244 putative cosubstrate binding site; other site 315750004245 catalytic site [active] 315750004246 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 315750004247 substrate binding site [chemical binding]; other site 315750004248 16S rRNA methyltransferase B; Provisional; Region: PRK14902 315750004249 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 315750004250 putative RNA binding site [nucleotide binding]; other site 315750004251 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750004252 S-adenosylmethionine binding site [chemical binding]; other site 315750004253 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 315750004254 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315750004255 FeS/SAM binding site; other site 315750004256 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 315750004257 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 315750004258 active site 315750004259 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 315750004260 Catalytic domain of Protein Kinases; Region: PKc; cd00180 315750004261 active site 315750004262 ATP binding site [chemical binding]; other site 315750004263 substrate binding site [chemical binding]; other site 315750004264 activation loop (A-loop); other site 315750004265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 315750004266 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 315750004267 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 315750004268 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 315750004269 GTPase RsgA; Reviewed; Region: PRK00098 315750004270 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 315750004271 RNA binding site [nucleotide binding]; other site 315750004272 homodimer interface [polypeptide binding]; other site 315750004273 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 315750004274 GTPase/Zn-binding domain interface [polypeptide binding]; other site 315750004275 GTP/Mg2+ binding site [chemical binding]; other site 315750004276 G4 box; other site 315750004277 G5 box; other site 315750004278 G1 box; other site 315750004279 Switch I region; other site 315750004280 G2 box; other site 315750004281 G3 box; other site 315750004282 Switch II region; other site 315750004283 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 315750004284 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 315750004285 substrate binding site [chemical binding]; other site 315750004286 hexamer interface [polypeptide binding]; other site 315750004287 metal binding site [ion binding]; metal-binding site 315750004288 Thiamine pyrophosphokinase; Region: TPK; cd07995 315750004289 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 315750004290 active site 315750004291 dimerization interface [polypeptide binding]; other site 315750004292 thiamine binding site [chemical binding]; other site 315750004293 Stage V sporulation protein family; Region: SpoV; cl15455 315750004294 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 315750004295 Asp23 family; Region: Asp23; cl00574 315750004296 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 315750004297 DAK2 domain; Region: Dak2; cl03685 315750004298 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 315750004299 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 315750004300 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 315750004301 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 315750004302 putative L-serine binding site [chemical binding]; other site 315750004303 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 315750004304 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 315750004305 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 315750004306 Y-family of DNA polymerases; Region: PolY; cl12025 315750004307 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 315750004308 generic binding surface II; other site 315750004309 ssDNA binding site; other site 315750004310 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315750004311 ATP binding site [chemical binding]; other site 315750004312 putative Mg++ binding site [ion binding]; other site 315750004313 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315750004314 nucleotide binding region [chemical binding]; other site 315750004315 ATP-binding site [chemical binding]; other site 315750004316 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 315750004317 Helix-turn-helix domains; Region: HTH; cl00088 315750004318 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 315750004319 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 315750004320 Acyl transferase domain; Region: Acyl_transf_1; cl08282 315750004321 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 315750004322 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 315750004323 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 315750004324 NAD(P) binding site [chemical binding]; other site 315750004325 homotetramer interface [polypeptide binding]; other site 315750004326 homodimer interface [polypeptide binding]; other site 315750004327 active site 315750004328 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315750004329 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 315750004330 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 315750004331 dimerization interface [polypeptide binding]; other site 315750004332 active site 315750004333 metal binding site [ion binding]; metal-binding site 315750004334 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 315750004335 dsRNA binding site [nucleotide binding]; other site 315750004336 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 315750004337 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 315750004338 Walker A/P-loop; other site 315750004339 ATP binding site [chemical binding]; other site 315750004340 Q-loop/lid; other site 315750004341 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 315750004342 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 315750004343 ABC transporter signature motif; other site 315750004344 Walker B; other site 315750004345 D-loop; other site 315750004346 H-loop/switch region; other site 315750004347 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 315750004348 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 315750004349 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 315750004350 P loop; other site 315750004351 GTP binding site [chemical binding]; other site 315750004352 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 315750004353 signal recognition particle protein; Provisional; Region: PRK10867 315750004354 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 315750004355 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 315750004356 P loop; other site 315750004357 GTP binding site [chemical binding]; other site 315750004358 Signal peptide binding domain; Region: SRP_SPB; pfam02978 315750004359 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 315750004360 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 315750004361 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 315750004362 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 315750004363 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 315750004364 RimM N-terminal domain; Region: RimM; pfam01782 315750004365 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 315750004366 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 315750004367 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 315750004368 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 315750004369 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 315750004370 GTP/Mg2+ binding site [chemical binding]; other site 315750004371 G4 box; other site 315750004372 G5 box; other site 315750004373 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 315750004374 G1 box; other site 315750004375 G1 box; other site 315750004376 GTP/Mg2+ binding site [chemical binding]; other site 315750004377 Switch I region; other site 315750004378 G2 box; other site 315750004379 G2 box; other site 315750004380 G3 box; other site 315750004381 G3 box; other site 315750004382 Switch II region; other site 315750004383 Switch II region; other site 315750004384 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 315750004385 RNA/DNA hybrid binding site [nucleotide binding]; other site 315750004386 active site 315750004387 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 315750004388 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 315750004389 ATP-grasp domain; Region: ATP-grasp_4; cl03087 315750004390 CoA-ligase; Region: Ligase_CoA; cl02894 315750004391 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 315750004392 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750004393 CoA-ligase; Region: Ligase_CoA; cl02894 315750004394 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 315750004395 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 315750004396 DNA topoisomerase I; Validated; Region: PRK05582 315750004397 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 315750004398 active site 315750004399 interdomain interaction site; other site 315750004400 putative metal-binding site [ion binding]; other site 315750004401 nucleotide binding site [chemical binding]; other site 315750004402 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 315750004403 domain I; other site 315750004404 DNA binding groove [nucleotide binding] 315750004405 phosphate binding site [ion binding]; other site 315750004406 domain II; other site 315750004407 domain III; other site 315750004408 nucleotide binding site [chemical binding]; other site 315750004409 catalytic site [active] 315750004410 domain IV; other site 315750004411 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 315750004412 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 315750004413 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 315750004414 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 315750004415 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750004416 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 315750004417 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 315750004418 active site 315750004419 Int/Topo IB signature motif; other site 315750004420 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 315750004421 active site 315750004422 HslU subunit interaction site [polypeptide binding]; other site 315750004423 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 315750004424 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750004425 Walker A motif; other site 315750004426 ATP binding site [chemical binding]; other site 315750004427 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750004428 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 315750004429 transcriptional repressor CodY; Validated; Region: PRK04158 315750004430 CodY GAF-like domain; Region: CodY; pfam06018 315750004431 Helix-turn-helix domains; Region: HTH; cl00088 315750004432 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 315750004433 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 315750004434 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 315750004435 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 315750004436 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 315750004437 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 315750004438 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 315750004439 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 315750004440 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 315750004441 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 315750004442 FliG C-terminal domain; Region: FliG_C; pfam01706 315750004443 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 315750004444 Flagellar assembly protein FliH; Region: FliH; pfam02108 315750004445 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 315750004446 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 315750004447 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 315750004448 Walker A motif/ATP binding site; other site 315750004449 Walker B motif; other site 315750004450 flagellar biosynthesis chaperone; Validated; Region: fliJ; cl09161 315750004451 MgtE intracellular N domain; Region: MgtE_N; cl15244 315750004452 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 315750004453 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 315750004454 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 315750004455 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 315750004456 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 315750004457 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 315750004458 Flagellar protein (FlbD); Region: FlbD; cl00683 315750004459 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 315750004460 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 315750004461 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 315750004462 flagellar motor switch protein; Validated; Region: PRK08119 315750004463 Chemotaxis phosphatase CheX; Region: CheX; cl15816 315750004464 Chemotaxis phosphatase CheX; Region: CheX; cl15816 315750004465 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 315750004466 Response regulator receiver domain; Region: Response_reg; pfam00072 315750004467 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750004468 active site 315750004469 phosphorylation site [posttranslational modification] 315750004470 intermolecular recognition site; other site 315750004471 dimerization interface [polypeptide binding]; other site 315750004472 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 315750004473 FliP family; Region: FliP; cl00593 315750004474 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 315750004475 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 315750004476 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 315750004477 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 315750004478 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 315750004479 FHIPEP family; Region: FHIPEP; pfam00771 315750004480 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 315750004481 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750004482 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 315750004483 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 315750004484 P-loop; other site 315750004485 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 315750004486 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 315750004487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750004488 active site 315750004489 phosphorylation site [posttranslational modification] 315750004490 intermolecular recognition site; other site 315750004491 dimerization interface [polypeptide binding]; other site 315750004492 CheB methylesterase; Region: CheB_methylest; pfam01339 315750004493 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 315750004494 putative binding surface; other site 315750004495 active site 315750004496 P2 response regulator binding domain; Region: P2; pfam07194 315750004497 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 315750004498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750004499 ATP binding site [chemical binding]; other site 315750004500 Mg2+ binding site [ion binding]; other site 315750004501 G-X-G motif; other site 315750004502 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 315750004503 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 315750004504 putative CheA interaction surface; other site 315750004505 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 315750004506 Chemotaxis phosphatase CheX; Region: CheX; cl15816 315750004507 Chemotaxis phosphatase CheX; Region: CheX; cl15816 315750004508 CheD chemotactic sensory transduction; Region: CheD; cl00810 315750004509 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 315750004510 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315750004511 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 315750004512 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315750004513 DNA binding residues [nucleotide binding] 315750004514 elongation factor Ts; Provisional; Region: tsf; PRK09377 315750004515 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 315750004516 Elongation factor TS; Region: EF_TS; pfam00889 315750004517 Elongation factor TS; Region: EF_TS; pfam00889 315750004518 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 315750004519 putative nucleotide binding site [chemical binding]; other site 315750004520 uridine monophosphate binding site [chemical binding]; other site 315750004521 homohexameric interface [polypeptide binding]; other site 315750004522 ribosome recycling factor; Reviewed; Region: frr; PRK00083 315750004523 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 315750004524 hinge region; other site 315750004525 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 315750004526 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 315750004527 catalytic residue [active] 315750004528 putative FPP diphosphate binding site; other site 315750004529 putative FPP binding hydrophobic cleft; other site 315750004530 dimer interface [polypeptide binding]; other site 315750004531 putative IPP diphosphate binding site; other site 315750004532 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 315750004533 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 315750004534 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 315750004535 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 315750004536 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 315750004537 RIP metalloprotease RseP; Region: TIGR00054 315750004538 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 315750004539 active site 315750004540 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 315750004541 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 315750004542 protein binding site [polypeptide binding]; other site 315750004543 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 315750004544 putative substrate binding region [chemical binding]; other site 315750004545 prolyl-tRNA synthetase; Provisional; Region: PRK09194 315750004546 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 315750004547 dimer interface [polypeptide binding]; other site 315750004548 motif 1; other site 315750004549 active site 315750004550 motif 2; other site 315750004551 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 315750004552 putative deacylase active site [active] 315750004553 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 315750004554 active site 315750004555 motif 3; other site 315750004556 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 315750004557 anticodon binding site; other site 315750004558 DNA polymerase III PolC; Validated; Region: polC; PRK00448 315750004559 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 315750004560 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 315750004561 generic binding surface II; other site 315750004562 generic binding surface I; other site 315750004563 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 315750004564 active site 315750004565 catalytic site [active] 315750004566 substrate binding site [chemical binding]; other site 315750004567 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1; Region: tRNA_synt_1c_R1; pfam04558 315750004568 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 315750004569 endoglucanase; Region: PLN02420 315750004570 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 315750004571 Cellulose binding domain; Region: CBM_3; cl03026 315750004572 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 315750004573 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 315750004574 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 315750004575 ribosome maturation protein RimP; Reviewed; Region: PRK00092 315750004576 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 315750004577 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 315750004578 Sm1 motif; other site 315750004579 predicted subunit interaction site [polypeptide binding]; other site 315750004580 RNA binding pocket [nucleotide binding]; other site 315750004581 Sm2 motif; other site 315750004582 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 315750004583 NusA N-terminal domain; Region: NusA_N; pfam08529 315750004584 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 315750004585 RNA binding site [nucleotide binding]; other site 315750004586 homodimer interface [polypeptide binding]; other site 315750004587 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 315750004588 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 315750004589 G-X-X-G motif; other site 315750004590 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 315750004591 putative RNA binding cleft [nucleotide binding]; other site 315750004592 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 315750004593 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 315750004594 translation initiation factor IF-2; Region: IF-2; TIGR00487 315750004595 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 315750004596 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 315750004597 G1 box; other site 315750004598 putative GEF interaction site [polypeptide binding]; other site 315750004599 GTP/Mg2+ binding site [chemical binding]; other site 315750004600 Switch I region; other site 315750004601 G2 box; other site 315750004602 G3 box; other site 315750004603 Switch II region; other site 315750004604 G4 box; other site 315750004605 G5 box; other site 315750004606 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 315750004607 Translation-initiation factor 2; Region: IF-2; pfam11987 315750004608 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 315750004609 Protein of unknown function (DUF503); Region: DUF503; cl00669 315750004610 Ribosome-binding factor A; Region: RBFA; cl00542 315750004611 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 315750004612 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 315750004613 RNA binding site [nucleotide binding]; other site 315750004614 active site 315750004615 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 315750004616 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 315750004617 active site 315750004618 Riboflavin kinase; Region: Flavokinase; cl03312 315750004619 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 315750004620 16S/18S rRNA binding site [nucleotide binding]; other site 315750004621 S13e-L30e interaction site [polypeptide binding]; other site 315750004622 25S rRNA binding site [nucleotide binding]; other site 315750004623 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 315750004624 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 315750004625 RNase E interface [polypeptide binding]; other site 315750004626 trimer interface [polypeptide binding]; other site 315750004627 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 315750004628 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 315750004629 RNase E interface [polypeptide binding]; other site 315750004630 trimer interface [polypeptide binding]; other site 315750004631 active site 315750004632 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 315750004633 putative nucleic acid binding region [nucleotide binding]; other site 315750004634 G-X-X-G motif; other site 315750004635 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 315750004636 RNA binding site [nucleotide binding]; other site 315750004637 domain interface; other site 315750004638 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 315750004639 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 315750004640 NodB motif; other site 315750004641 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 315750004642 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 315750004643 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 315750004644 Phosphotransferase enzyme family; Region: APH; pfam01636 315750004645 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 315750004646 active site 315750004647 ATP binding site [chemical binding]; other site 315750004648 substrate binding site [chemical binding]; other site 315750004649 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 315750004650 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 315750004651 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750004652 Flavoprotein; Region: Flavoprotein; cl08021 315750004653 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 315750004654 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750004655 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 315750004656 aspartate kinase I; Reviewed; Region: PRK08210 315750004657 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 315750004658 nucleotide binding site [chemical binding]; other site 315750004659 substrate binding site [chemical binding]; other site 315750004660 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 315750004661 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 315750004662 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 315750004663 dihydrodipicolinate synthase; Region: dapA; TIGR00674 315750004664 dimer interface [polypeptide binding]; other site 315750004665 active site 315750004666 catalytic residue [active] 315750004667 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 315750004668 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315750004669 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 315750004670 Clp protease; Region: CLP_protease; pfam00574 315750004671 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 315750004672 active site 315750004673 YlzJ-like protein; Region: YlzJ; pfam14035 315750004674 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 315750004675 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 315750004676 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750004677 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 315750004678 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 315750004679 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315750004680 DNA-binding site [nucleotide binding]; DNA binding site 315750004681 UTRA domain; Region: UTRA; cl01230 315750004682 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 315750004683 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 315750004684 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 315750004685 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 315750004686 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 315750004687 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 315750004688 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 315750004689 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 315750004690 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315750004691 Helix-turn-helix domains; Region: HTH; cl00088 315750004692 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 315750004693 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 315750004694 dimer interface [polypeptide binding]; other site 315750004695 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 315750004696 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 315750004697 classical (c) SDRs; Region: SDR_c; cd05233 315750004698 NAD(P) binding site [chemical binding]; other site 315750004699 active site 315750004700 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 315750004701 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 315750004702 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 315750004703 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 315750004704 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 315750004705 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 315750004706 competence damage-inducible protein A; Provisional; Region: PRK00549 315750004707 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 315750004708 putative MPT binding site; other site 315750004709 Competence-damaged protein; Region: CinA; cl00666 315750004710 recombinase A; Provisional; Region: recA; PRK09354 315750004711 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 315750004712 hexamer interface [polypeptide binding]; other site 315750004713 Walker A motif; other site 315750004714 ATP binding site [chemical binding]; other site 315750004715 Walker B motif; other site 315750004716 phosphodiesterase; Provisional; Region: PRK12704 315750004717 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 315750004718 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 315750004719 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 315750004720 putative active site [active] 315750004721 metal binding site [ion binding]; metal-binding site 315750004722 homodimer binding site [polypeptide binding]; other site 315750004723 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 315750004724 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 315750004725 Protein export membrane protein; Region: SecD_SecF; cl14618 315750004726 Threonine dehydrogenase; Region: TDH; cd05281 315750004727 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 315750004728 structural Zn binding site [ion binding]; other site 315750004729 catalytic Zn binding site [ion binding]; other site 315750004730 tetramer interface [polypeptide binding]; other site 315750004731 NADP binding site [chemical binding]; other site 315750004732 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 315750004733 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 315750004734 substrate-cofactor binding pocket; other site 315750004735 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750004736 catalytic residue [active] 315750004737 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 315750004738 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 315750004739 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315750004740 FeS/SAM binding site; other site 315750004741 TRAM domain; Region: TRAM; cl01282 315750004742 Protein of unknown function (DUF964); Region: DUF964; cl01483 315750004743 Outer spore coat protein E (CotE); Region: CotE; pfam10628 315750004744 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 315750004745 MutS domain I; Region: MutS_I; pfam01624 315750004746 MutS domain II; Region: MutS_II; pfam05188 315750004747 MutS family domain IV; Region: MutS_IV; pfam05190 315750004748 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 315750004749 Walker A/P-loop; other site 315750004750 ATP binding site [chemical binding]; other site 315750004751 Q-loop/lid; other site 315750004752 ABC transporter signature motif; other site 315750004753 Walker B; other site 315750004754 D-loop; other site 315750004755 H-loop/switch region; other site 315750004756 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 315750004757 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750004758 ATP binding site [chemical binding]; other site 315750004759 Mg2+ binding site [ion binding]; other site 315750004760 G-X-G motif; other site 315750004761 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 315750004762 ATP binding site [chemical binding]; other site 315750004763 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 315750004764 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 315750004765 Protein of unknown function (DUF867); Region: DUF867; cl01713 315750004766 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750004767 TPR motif; other site 315750004768 binding surface 315750004769 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 315750004770 active site 315750004771 catalytic triad [active] 315750004772 Protein of unknown function (DUF867); Region: DUF867; cl01713 315750004773 OsmC-like protein; Region: OsmC; cl00767 315750004774 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 315750004775 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 315750004776 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750004777 Helix-turn-helix domains; Region: HTH; cl00088 315750004778 YmaF family; Region: YmaF; pfam12788 315750004779 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750004780 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 315750004781 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 315750004782 Sm1 motif; other site 315750004783 intra - hexamer interaction site; other site 315750004784 inter - hexamer interaction site [polypeptide binding]; other site 315750004785 nucleotide binding pocket [chemical binding]; other site 315750004786 Sm2 motif; other site 315750004787 YmzC-like protein; Region: YmzC; pfam14157 315750004788 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 315750004789 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 315750004790 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 315750004791 Class I ribonucleotide reductase; Region: RNR_I; cd01679 315750004792 active site 315750004793 dimer interface [polypeptide binding]; other site 315750004794 catalytic residues [active] 315750004795 effector binding site; other site 315750004796 R2 peptide binding site; other site 315750004797 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 315750004798 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 315750004799 dimer interface [polypeptide binding]; other site 315750004800 putative radical transfer pathway; other site 315750004801 diiron center [ion binding]; other site 315750004802 tyrosyl radical; other site 315750004803 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 315750004804 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 315750004805 active site 315750004806 metal binding site [ion binding]; metal-binding site 315750004807 Sporulation related domain; Region: SPOR; cl10051 315750004808 stage V sporulation protein K; Region: spore_V_K; TIGR02881 315750004809 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750004810 Walker A motif; other site 315750004811 ATP binding site [chemical binding]; other site 315750004812 Walker B motif; other site 315750004813 arginine finger; other site 315750004814 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 315750004815 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 315750004816 HflX GTPase family; Region: HflX; cd01878 315750004817 G1 box; other site 315750004818 GTP/Mg2+ binding site [chemical binding]; other site 315750004819 Switch I region; other site 315750004820 G2 box; other site 315750004821 G3 box; other site 315750004822 Switch II region; other site 315750004823 G4 box; other site 315750004824 G5 box; other site 315750004825 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 315750004826 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 315750004827 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 315750004828 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315750004829 DNA binding residues [nucleotide binding] 315750004830 putative dimer interface [polypeptide binding]; other site 315750004831 glutamine synthetase, type I; Region: GlnA; TIGR00653 315750004832 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 315750004833 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 315750004834 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 315750004835 active site 315750004836 nucleophile elbow; other site 315750004837 positive control sigma-like factor; Validated; Region: PRK06930 315750004838 positive control sigma-like factor; Validated; Region: PRK06930 315750004839 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 315750004840 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750004841 binding surface 315750004842 TPR motif; other site 315750004843 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315750004844 Uncharacterized conserved protein [Function unknown]; Region: COG5444 315750004845 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 315750004846 Protein of unknown function, DUF600; Region: DUF600; cl04640 315750004847 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 315750004848 Protein of unknown function, DUF600; Region: DUF600; cl04640 315750004849 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 315750004850 ADP-ribose binding site [chemical binding]; other site 315750004851 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315750004852 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315750004853 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 315750004854 active site 315750004855 Protein of unknown function (DUF419); Region: DUF419; cl15265 315750004856 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 315750004857 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315750004858 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 315750004859 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 315750004860 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 315750004861 active site 315750004862 DNA binding site [nucleotide binding] 315750004863 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 315750004864 nucleotide binding site [chemical binding]; other site 315750004865 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 315750004866 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 315750004867 putative DNA binding site [nucleotide binding]; other site 315750004868 putative homodimer interface [polypeptide binding]; other site 315750004869 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 315750004870 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 315750004871 active site 315750004872 metal binding site [ion binding]; metal-binding site 315750004873 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315750004874 Rrf2 family protein; Region: rrf2_super; TIGR00738 315750004875 Helix-turn-helix domains; Region: HTH; cl00088 315750004876 Helix-turn-helix domains; Region: HTH; cl00088 315750004877 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 315750004878 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 315750004879 NADP binding site [chemical binding]; other site 315750004880 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 315750004881 Cysteine-rich domain; Region: CCG; pfam02754 315750004882 Cysteine-rich domain; Region: CCG; pfam02754 315750004883 iron-sulfur cluster-binding protein; Region: TIGR00273 315750004884 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 315750004885 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 315750004886 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 315750004887 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 315750004888 EamA-like transporter family; Region: EamA; cl01037 315750004889 EamA-like transporter family; Region: EamA; cl01037 315750004890 Predicted kinase [General function prediction only]; Region: COG4639 315750004891 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 315750004892 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 315750004893 active site 315750004894 metal binding site [ion binding]; metal-binding site 315750004895 RNA ligase; Region: RNA_lig_T4_1; cl09743 315750004896 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750004897 Helix-turn-helix domains; Region: HTH; cl00088 315750004898 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 315750004899 Cytochrome P450; Region: p450; pfam00067 315750004900 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 315750004901 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 315750004902 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 315750004903 FAD binding pocket [chemical binding]; other site 315750004904 FAD binding motif [chemical binding]; other site 315750004905 catalytic residues [active] 315750004906 NAD binding pocket [chemical binding]; other site 315750004907 phosphate binding motif [ion binding]; other site 315750004908 beta-alpha-beta structure motif; other site 315750004909 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 315750004910 active site 315750004911 substrate binding sites [chemical binding]; other site 315750004912 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 315750004913 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 315750004914 LexA repressor; Validated; Region: PRK00215 315750004915 Helix-turn-helix domains; Region: HTH; cl00088 315750004916 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 315750004917 Catalytic site [active] 315750004918 cell division suppressor protein YneA; Provisional; Region: PRK14125 315750004919 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 315750004920 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 315750004921 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 315750004922 catalytic residues [active] 315750004923 catalytic nucleophile [active] 315750004924 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 315750004925 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 315750004926 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 315750004927 TPP-binding site [chemical binding]; other site 315750004928 dimer interface [polypeptide binding]; other site 315750004929 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 315750004930 PYR/PP interface [polypeptide binding]; other site 315750004931 dimer interface [polypeptide binding]; other site 315750004932 TPP binding site [chemical binding]; other site 315750004933 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 315750004934 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 315750004935 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 315750004936 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 315750004937 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 315750004938 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 315750004939 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 315750004940 Small acid-soluble spore protein P family; Region: SspP; cl12105 315750004941 Small acid-soluble spore protein O family; Region: SspO; cl07943 315750004942 aconitate hydratase; Validated; Region: PRK09277 315750004943 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 315750004944 substrate binding site [chemical binding]; other site 315750004945 ligand binding site [chemical binding]; other site 315750004946 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 315750004947 substrate binding site [chemical binding]; other site 315750004948 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 315750004949 catalytic residues [active] 315750004950 Small acid-soluble spore protein N family; Region: SspN; cl11659 315750004951 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830; cl07951 315750004952 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 315750004953 active site 315750004954 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 315750004955 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 315750004956 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750004957 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 315750004958 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750004959 ATP binding site [chemical binding]; other site 315750004960 Mg2+ binding site [ion binding]; other site 315750004961 G-X-G motif; other site 315750004962 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 315750004963 anchoring element; other site 315750004964 dimer interface [polypeptide binding]; other site 315750004965 ATP binding site [chemical binding]; other site 315750004966 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 315750004967 active site 315750004968 putative metal-binding site [ion binding]; other site 315750004969 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 315750004970 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 315750004971 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 315750004972 CAP-like domain; other site 315750004973 active site 315750004974 primary dimer interface [polypeptide binding]; other site 315750004975 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315750004976 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315750004977 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315750004978 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315750004979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750004980 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 315750004981 active site 315750004982 FMN binding site [chemical binding]; other site 315750004983 substrate binding site [chemical binding]; other site 315750004984 homotetramer interface [polypeptide binding]; other site 315750004985 catalytic residue [active] 315750004986 Helix-turn-helix domains; Region: HTH; cl00088 315750004987 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 315750004988 Helix-turn-helix domains; Region: HTH; cl00088 315750004989 threonine synthase; Validated; Region: PRK08329 315750004990 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 315750004991 homodimer interface [polypeptide binding]; other site 315750004992 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750004993 catalytic residue [active] 315750004994 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 315750004995 homotrimer interaction site [polypeptide binding]; other site 315750004996 putative active site [active] 315750004997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 315750004998 YheO-like PAS domain; Region: PAS_6; pfam08348 315750004999 Helix-turn-helix domains; Region: HTH; cl00088 315750005000 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315750005001 Helix-turn-helix domains; Region: HTH; cl00088 315750005002 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 315750005003 Helix-turn-helix domains; Region: HTH; cl00088 315750005004 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 315750005005 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 315750005006 Thioredoxin; Region: Thioredoxin_5; pfam13743 315750005007 catalytic residues [active] 315750005008 Putative mono-oxygenase ydhR; Region: ydhR; cl07420 315750005009 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 315750005010 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 315750005011 active site 315750005012 catalytic motif [active] 315750005013 Zn binding site [ion binding]; other site 315750005014 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315750005015 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 315750005016 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 315750005017 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315750005018 DNA binding residues [nucleotide binding] 315750005019 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 315750005020 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 315750005021 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 315750005022 active site turn [active] 315750005023 phosphorylation site [posttranslational modification] 315750005024 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 315750005025 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 315750005026 HPr interaction site; other site 315750005027 glycerol kinase (GK) interaction site [polypeptide binding]; other site 315750005028 active site 315750005029 phosphorylation site [posttranslational modification] 315750005030 CAT RNA binding domain; Region: CAT_RBD; cl03904 315750005031 transcriptional antiterminator BglG; Provisional; Region: PRK09772 315750005032 PRD domain; Region: PRD; cl15445 315750005033 PRD domain; Region: PRD; cl15445 315750005034 Tic20-like protein; Region: Tic20; pfam09685 315750005035 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 315750005036 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315750005037 dimer interface [polypeptide binding]; other site 315750005038 phosphorylation site [posttranslational modification] 315750005039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750005040 ATP binding site [chemical binding]; other site 315750005041 Mg2+ binding site [ion binding]; other site 315750005042 G-X-G motif; other site 315750005043 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750005044 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315750005045 active site 315750005046 phosphorylation site [posttranslational modification] 315750005047 intermolecular recognition site; other site 315750005048 dimerization interface [polypeptide binding]; other site 315750005049 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315750005050 DNA binding site [nucleotide binding] 315750005051 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 315750005052 Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057 315750005053 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 315750005054 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 315750005055 substrate binding site [chemical binding]; other site 315750005056 active site 315750005057 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 315750005058 metal binding site [ion binding]; metal-binding site 315750005059 ligand binding site [chemical binding]; other site 315750005060 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 315750005061 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 315750005062 tetrameric interface [polypeptide binding]; other site 315750005063 NAD binding site [chemical binding]; other site 315750005064 catalytic residues [active] 315750005065 alpha-galactosidase; Provisional; Region: PRK15076 315750005066 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 315750005067 NAD binding site [chemical binding]; other site 315750005068 sugar binding site [chemical binding]; other site 315750005069 divalent metal binding site [ion binding]; other site 315750005070 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 315750005071 dimer interface [polypeptide binding]; other site 315750005072 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 315750005073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750005074 dimer interface [polypeptide binding]; other site 315750005075 conserved gate region; other site 315750005076 putative PBP binding loops; other site 315750005077 ABC-ATPase subunit interface; other site 315750005078 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 315750005079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750005080 dimer interface [polypeptide binding]; other site 315750005081 conserved gate region; other site 315750005082 putative PBP binding loops; other site 315750005083 ABC-ATPase subunit interface; other site 315750005084 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 315750005085 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 315750005086 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 315750005087 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 315750005088 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315750005089 DNA binding site [nucleotide binding] 315750005090 domain linker motif; other site 315750005091 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 315750005092 putative ligand binding site [chemical binding]; other site 315750005093 putative dimerization interface [polypeptide binding]; other site 315750005094 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 315750005095 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 315750005096 substrate binding site [chemical binding]; other site 315750005097 hexamer interface [polypeptide binding]; other site 315750005098 metal binding site [ion binding]; metal-binding site 315750005099 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 315750005100 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 315750005101 active site 315750005102 P-loop; other site 315750005103 phosphorylation site [posttranslational modification] 315750005104 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 315750005105 Helix-turn-helix domains; Region: HTH; cl00088 315750005106 PRD domain; Region: PRD; cl15445 315750005107 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 315750005108 active site 315750005109 P-loop; other site 315750005110 phosphorylation site [posttranslational modification] 315750005111 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 315750005112 active site 315750005113 phosphorylation site [posttranslational modification] 315750005114 Uncharacterized conserved protein [Function unknown]; Region: COG5444 315750005115 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 315750005116 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 315750005117 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315750005118 Helix-turn-helix domains; Region: HTH; cl00088 315750005119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750005120 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315750005121 putative substrate translocation pore; other site 315750005122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750005123 hypothetical protein; Provisional; Region: PRK08185 315750005124 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 315750005125 intersubunit interface [polypeptide binding]; other site 315750005126 active site 315750005127 zinc binding site [ion binding]; other site 315750005128 Na+ binding site [ion binding]; other site 315750005129 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 315750005130 active site 315750005131 phosphorylation site [posttranslational modification] 315750005132 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 315750005133 active site 315750005134 P-loop; other site 315750005135 phosphorylation site [posttranslational modification] 315750005136 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 315750005137 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 315750005138 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 315750005139 putative substrate binding site [chemical binding]; other site 315750005140 putative ATP binding site [chemical binding]; other site 315750005141 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 315750005142 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 315750005143 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 315750005144 putative active site [active] 315750005145 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 315750005146 PLD-like domain; Region: PLDc_2; pfam13091 315750005147 putative active site [active] 315750005148 catalytic site [active] 315750005149 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 315750005150 PLD-like domain; Region: PLDc_2; pfam13091 315750005151 putative active site [active] 315750005152 catalytic site [active] 315750005153 Protein of unknown function, DUF606; Region: DUF606; cl01273 315750005154 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 315750005155 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 315750005156 ligand binding site [chemical binding]; other site 315750005157 flexible hinge region; other site 315750005158 Helix-turn-helix domains; Region: HTH; cl00088 315750005159 Protein of unknown function, DUF606; Region: DUF606; cl01273 315750005160 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 315750005161 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 315750005162 NAD binding site [chemical binding]; other site 315750005163 catalytic residues [active] 315750005164 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 315750005165 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 315750005166 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 315750005167 FAD binding pocket [chemical binding]; other site 315750005168 FAD binding motif [chemical binding]; other site 315750005169 catalytic residues [active] 315750005170 NAD binding pocket [chemical binding]; other site 315750005171 phosphate binding motif [ion binding]; other site 315750005172 beta-alpha-beta structure motif; other site 315750005173 sulfite reductase subunit beta; Provisional; Region: PRK13504 315750005174 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 315750005175 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 315750005176 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 315750005177 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 315750005178 AMP-binding enzyme; Region: AMP-binding; cl15778 315750005179 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315750005180 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 315750005181 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 315750005182 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 315750005183 enoyl-CoA hydratase; Provisional; Region: PRK07657 315750005184 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 315750005185 substrate binding site [chemical binding]; other site 315750005186 oxyanion hole (OAH) forming residues; other site 315750005187 trimer interface [polypeptide binding]; other site 315750005188 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 315750005189 active site 315750005190 catalytic residues [active] 315750005191 metal binding site [ion binding]; metal-binding site 315750005192 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 315750005193 carboxyltransferase (CT) interaction site; other site 315750005194 biotinylation site [posttranslational modification]; other site 315750005195 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 315750005196 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 315750005197 ATP-grasp domain; Region: ATP-grasp_4; cl03087 315750005198 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 315750005199 AMP-binding domain protein; Validated; Region: PRK08315 315750005200 AMP-binding enzyme; Region: AMP-binding; cl15778 315750005201 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315750005202 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 315750005203 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 315750005204 FAD binding site [chemical binding]; other site 315750005205 homotetramer interface [polypeptide binding]; other site 315750005206 substrate binding pocket [chemical binding]; other site 315750005207 catalytic base [active] 315750005208 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 315750005209 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 315750005210 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 315750005211 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 315750005212 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 315750005213 Helix-turn-helix domains; Region: HTH; cl00088 315750005214 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 315750005215 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 315750005216 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 315750005217 Helix-turn-helix domains; Region: HTH; cl00088 315750005218 FAD binding domain; Region: FAD_binding_4; pfam01565 315750005219 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 315750005220 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 315750005221 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 315750005222 Cysteine-rich domain; Region: CCG; pfam02754 315750005223 Cysteine-rich domain; Region: CCG; pfam02754 315750005224 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 315750005225 Spore germination protein; Region: Spore_permease; cl15802 315750005226 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 315750005227 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 315750005228 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 315750005229 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 315750005230 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 315750005231 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 315750005232 active site 315750005233 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 315750005234 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 315750005235 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 315750005236 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 315750005237 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 315750005238 trimer interface [polypeptide binding]; other site 315750005239 active site 315750005240 substrate binding site [chemical binding]; other site 315750005241 CoA binding site [chemical binding]; other site 315750005242 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 315750005243 MatE; Region: MatE; cl10513 315750005244 MatE; Region: MatE; cl10513 315750005245 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 315750005246 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315750005247 Pectinesterase; Region: Pectinesterase; cl01911 315750005248 Protein of unknown function (DUF421); Region: DUF421; cl00990 315750005249 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 315750005250 [2Fe-2S] cluster binding site [ion binding]; other site 315750005251 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 315750005252 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315750005253 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 315750005254 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 315750005255 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 315750005256 Transposase domain (DUF772); Region: DUF772; pfam05598 315750005257 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 315750005258 DDE superfamily endonuclease; Region: DDE_4; cl15789 315750005259 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 315750005260 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315750005261 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 315750005262 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 315750005263 active site 315750005264 dimer interface [polypeptide binding]; other site 315750005265 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 315750005266 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 315750005267 active site 315750005268 FMN binding site [chemical binding]; other site 315750005269 substrate binding site [chemical binding]; other site 315750005270 3Fe-4S cluster binding site [ion binding]; other site 315750005271 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 315750005272 domain interface; other site 315750005273 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315750005274 Helix-turn-helix domains; Region: HTH; cl00088 315750005275 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 315750005276 putative dimerization interface [polypeptide binding]; other site 315750005277 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 315750005278 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 315750005279 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750005280 Walker A/P-loop; other site 315750005281 ATP binding site [chemical binding]; other site 315750005282 Q-loop/lid; other site 315750005283 ABC transporter signature motif; other site 315750005284 Walker B; other site 315750005285 D-loop; other site 315750005286 H-loop/switch region; other site 315750005287 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 315750005288 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 315750005289 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 315750005290 Walker A/P-loop; other site 315750005291 ATP binding site [chemical binding]; other site 315750005292 Q-loop/lid; other site 315750005293 ABC transporter signature motif; other site 315750005294 Walker B; other site 315750005295 D-loop; other site 315750005296 H-loop/switch region; other site 315750005297 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 315750005298 DNA binding residues [nucleotide binding] 315750005299 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315750005300 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 315750005301 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315750005302 Transposase domain (DUF772); Region: DUF772; pfam05598 315750005303 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 315750005304 DDE superfamily endonuclease; Region: DDE_4; cl15789 315750005305 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315750005306 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315750005307 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 315750005308 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 315750005309 putative catalytic cysteine [active] 315750005310 gamma-glutamyl kinase; Provisional; Region: PRK13402 315750005311 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 315750005312 nucleotide binding site [chemical binding]; other site 315750005313 homotetrameric interface [polypeptide binding]; other site 315750005314 putative phosphate binding site [ion binding]; other site 315750005315 putative allosteric binding site; other site 315750005316 PUA domain; Region: PUA; cl00607 315750005317 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750005318 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 315750005319 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 315750005320 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 315750005321 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 315750005322 putative [4Fe-4S] binding site [ion binding]; other site 315750005323 putative molybdopterin cofactor binding site [chemical binding]; other site 315750005324 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 315750005325 putative molybdopterin cofactor binding site; other site 315750005326 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 315750005327 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 315750005328 N- and C-terminal domain interface [polypeptide binding]; other site 315750005329 D-xylulose kinase; Region: XylB; TIGR01312 315750005330 active site 315750005331 catalytic site [active] 315750005332 metal binding site [ion binding]; metal-binding site 315750005333 xylulose binding site [chemical binding]; other site 315750005334 putative ATP binding site [chemical binding]; other site 315750005335 homodimer interface [polypeptide binding]; other site 315750005336 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 315750005337 Helix-turn-helix domains; Region: HTH; cl00088 315750005338 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 315750005339 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 315750005340 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 315750005341 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 315750005342 inhibitor binding site; inhibition site 315750005343 active site 315750005344 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 315750005345 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 315750005346 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 315750005347 dimer interface [polypeptide binding]; other site 315750005348 putative tRNA-binding site [nucleotide binding]; other site 315750005349 YndJ-like protein; Region: YndJ; pfam14158 315750005350 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 315750005351 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 315750005352 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750005353 Helix-turn-helix domains; Region: HTH; cl00088 315750005354 WHG domain; Region: WHG; pfam13305 315750005355 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315750005356 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 315750005357 Predicted transcriptional regulator [Transcription]; Region: COG2378 315750005358 Helix-turn-helix domains; Region: HTH; cl00088 315750005359 WYL domain; Region: WYL; cl14852 315750005360 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315750005361 dimerization interface [polypeptide binding]; other site 315750005362 putative DNA binding site [nucleotide binding]; other site 315750005363 putative Zn2+ binding site [ion binding]; other site 315750005364 amino acid transporter; Region: 2A0306; TIGR00909 315750005365 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 315750005366 N-acetyl-D-glucosamine binding site [chemical binding]; other site 315750005367 catalytic residue [active] 315750005368 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 315750005369 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 315750005370 tetramer interface [polypeptide binding]; other site 315750005371 active site 315750005372 Mg2+/Mn2+ binding site [ion binding]; other site 315750005373 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 315750005374 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 315750005375 dimer interface [polypeptide binding]; other site 315750005376 Citrate synthase; Region: Citrate_synt; pfam00285 315750005377 active site 315750005378 coenzyme A binding site [chemical binding]; other site 315750005379 citrylCoA binding site [chemical binding]; other site 315750005380 oxalacetate/citrate binding site [chemical binding]; other site 315750005381 catalytic triad [active] 315750005382 Protein of unknown function (DUF420); Region: DUF420; cl00989 315750005383 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315750005384 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 315750005385 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 315750005386 3D domain; Region: 3D; cl01439 315750005387 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 315750005388 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315750005389 ATP binding site [chemical binding]; other site 315750005390 putative Mg++ binding site [ion binding]; other site 315750005391 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315750005392 nucleotide binding region [chemical binding]; other site 315750005393 ATP-binding site [chemical binding]; other site 315750005394 RQC domain; Region: RQC; cl09632 315750005395 HRDC domain; Region: HRDC; cl02578 315750005396 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 315750005397 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 315750005398 NADH(P)-binding; Region: NAD_binding_10; pfam13460 315750005399 NAD(P) binding site [chemical binding]; other site 315750005400 putative active site [active] 315750005401 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 315750005402 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 315750005403 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 315750005404 NAD(P) binding site [chemical binding]; other site 315750005405 catalytic residues [active] 315750005406 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 315750005407 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 315750005408 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 315750005409 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 315750005410 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 315750005411 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 315750005412 Membrane transport protein; Region: Mem_trans; cl09117 315750005413 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 315750005414 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 315750005415 E3 interaction surface; other site 315750005416 lipoyl attachment site [posttranslational modification]; other site 315750005417 e3 binding domain; Region: E3_binding; pfam02817 315750005418 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 315750005419 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 315750005420 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 315750005421 TPP-binding site [chemical binding]; other site 315750005422 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 315750005423 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 315750005424 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 315750005425 metal ion-dependent adhesion site (MIDAS); other site 315750005426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750005427 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 315750005428 Walker A motif; other site 315750005429 ATP binding site [chemical binding]; other site 315750005430 Walker B motif; other site 315750005431 arginine finger; other site 315750005432 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 315750005433 E-class dimer interface [polypeptide binding]; other site 315750005434 P-class dimer interface [polypeptide binding]; other site 315750005435 active site 315750005436 Cu2+ binding site [ion binding]; other site 315750005437 Zn2+ binding site [ion binding]; other site 315750005438 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 315750005439 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 315750005440 multidrug efflux protein; Reviewed; Region: PRK01766 315750005441 MatE; Region: MatE; cl10513 315750005442 MatE; Region: MatE; cl10513 315750005443 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 315750005444 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 315750005445 Predicted permeases [General function prediction only]; Region: RarD; COG2962 315750005446 EamA-like transporter family; Region: EamA; cl01037 315750005447 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 315750005448 Helix-turn-helix domains; Region: HTH; cl00088 315750005449 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 315750005450 dimer interface [polypeptide binding]; other site 315750005451 FMN binding site [chemical binding]; other site 315750005452 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 315750005453 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 315750005454 Na binding site [ion binding]; other site 315750005455 Leucine carboxyl methyltransferase; Region: LCM; cl01306 315750005456 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 315750005457 C-terminal peptidase (prc); Region: prc; TIGR00225 315750005458 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 315750005459 protein binding site [polypeptide binding]; other site 315750005460 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 315750005461 Catalytic dyad [active] 315750005462 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 315750005463 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 315750005464 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750005465 S-adenosylmethionine binding site [chemical binding]; other site 315750005466 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 315750005467 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 315750005468 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 315750005469 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 315750005470 active site 315750005471 YozD-like protein; Region: YozD; pfam14162 315750005472 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 315750005473 YokU-like protein; Region: YokU; cl15819 315750005474 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 315750005475 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315750005476 FeS/SAM binding site; other site 315750005477 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 315750005478 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 315750005479 sensory histidine kinase AtoS; Provisional; Region: PRK11360 315750005480 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750005481 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 315750005482 Walker A motif; other site 315750005483 ATP binding site [chemical binding]; other site 315750005484 Walker B motif; other site 315750005485 arginine finger; other site 315750005486 Helix-turn-helix domains; Region: HTH; cl00088 315750005487 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 315750005488 active site 315750005489 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 315750005490 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 315750005491 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 315750005492 active site 315750005493 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 315750005494 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 315750005495 NAD(P) binding site [chemical binding]; other site 315750005496 homodimer interface [polypeptide binding]; other site 315750005497 substrate binding site [chemical binding]; other site 315750005498 active site 315750005499 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 315750005500 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 315750005501 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 315750005502 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315750005503 Helix-turn-helix domains; Region: HTH; cl00088 315750005504 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 315750005505 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 315750005506 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 315750005507 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 315750005508 active site 315750005509 catalytic triad [active] 315750005510 oxyanion hole [active] 315750005511 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 315750005512 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 315750005513 Cu(I) binding site [ion binding]; other site 315750005514 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 315750005515 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 315750005516 threonine dehydratase; Validated; Region: PRK08639 315750005517 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 315750005518 tetramer interface [polypeptide binding]; other site 315750005519 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750005520 catalytic residue [active] 315750005521 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 315750005522 putative Ile/Val binding site [chemical binding]; other site 315750005523 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 315750005524 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750005525 Walker A motif; other site 315750005526 ATP binding site [chemical binding]; other site 315750005527 Walker B motif; other site 315750005528 arginine finger; other site 315750005529 Haemolysin-III related; Region: HlyIII; cl03831 315750005530 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 315750005531 putative acyl-acceptor binding pocket; other site 315750005532 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 315750005533 folate binding site [chemical binding]; other site 315750005534 NADP+ binding site [chemical binding]; other site 315750005535 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 315750005536 dimerization interface [polypeptide binding]; other site 315750005537 active site 315750005538 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 315750005539 tetramer interfaces [polypeptide binding]; other site 315750005540 binuclear metal-binding site [ion binding]; other site 315750005541 YpjP-like protein; Region: YpjP; pfam14005 315750005542 Predicted methyltransferase [General function prediction only]; Region: COG2520 315750005543 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750005544 S-adenosylmethionine binding site [chemical binding]; other site 315750005545 Disulphide isomerase; Region: Disulph_isomer; cl05813 315750005546 Dehydratase family; Region: ILVD_EDD; cl00340 315750005547 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 315750005548 Virulence factor; Region: Virulence_fact; pfam13769 315750005549 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 315750005550 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 315750005551 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 315750005552 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 315750005553 catalytic residues [active] 315750005554 dimer interface [polypeptide binding]; other site 315750005555 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 315750005556 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 315750005557 Potassium binding sites [ion binding]; other site 315750005558 Cesium cation binding sites [ion binding]; other site 315750005559 homoserine O-succinyltransferase; Provisional; Region: PRK05368 315750005560 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 315750005561 proposed active site lysine [active] 315750005562 conserved cys residue [active] 315750005563 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 315750005564 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 315750005565 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 315750005566 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 315750005567 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 315750005568 DNA-binding site [nucleotide binding]; DNA binding site 315750005569 RNA-binding motif; other site 315750005570 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 315750005571 hypothetical protein; Validated; Region: PRK07708 315750005572 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 315750005573 RNA/DNA hybrid binding site [nucleotide binding]; other site 315750005574 active site 315750005575 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 315750005576 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 315750005577 RNA/DNA hybrid binding site [nucleotide binding]; other site 315750005578 active site 315750005579 5'-3' exonuclease; Region: 53EXOc; smart00475 315750005580 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 315750005581 active site 315750005582 metal binding site 1 [ion binding]; metal-binding site 315750005583 putative 5' ssDNA interaction site; other site 315750005584 metal binding site 3; metal-binding site 315750005585 metal binding site 2 [ion binding]; metal-binding site 315750005586 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 315750005587 putative DNA binding site [nucleotide binding]; other site 315750005588 putative metal binding site [ion binding]; other site 315750005589 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 315750005590 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 315750005591 Dynamin family; Region: Dynamin_N; pfam00350 315750005592 G1 box; other site 315750005593 GTP/Mg2+ binding site [chemical binding]; other site 315750005594 G2 box; other site 315750005595 Switch I region; other site 315750005596 G3 box; other site 315750005597 Switch II region; other site 315750005598 G4 box; other site 315750005599 G5 box; other site 315750005600 Dynamin family; Region: Dynamin_N; pfam00350 315750005601 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 315750005602 G3 box; other site 315750005603 Switch II region; other site 315750005604 GTP/Mg2+ binding site [chemical binding]; other site 315750005605 G4 box; other site 315750005606 G5 box; other site 315750005607 Phospholipid methyltransferase; Region: PEMT; cl00763 315750005608 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 315750005609 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 315750005610 malonyl-CoA binding site [chemical binding]; other site 315750005611 dimer interface [polypeptide binding]; other site 315750005612 active site 315750005613 product binding site; other site 315750005614 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 315750005615 NodB motif; other site 315750005616 active site 315750005617 catalytic site [active] 315750005618 Zn binding site [ion binding]; other site 315750005619 xanthine permease; Region: pbuX; TIGR03173 315750005620 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 315750005621 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 315750005622 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 315750005623 active site 315750005624 Zn binding site [ion binding]; other site 315750005625 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 315750005626 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750005627 putative transposase OrfB; Reviewed; Region: PHA02517 315750005628 HTH-like domain; Region: HTH_21; pfam13276 315750005629 Integrase core domain; Region: rve; cl01316 315750005630 Integrase core domain; Region: rve_3; cl15866 315750005631 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 315750005632 THUMP domain; Region: THUMP; cl12076 315750005633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 315750005634 cell division protein GpsB; Provisional; Region: PRK14127 315750005635 DivIVA domain; Region: DivI1A_domain; TIGR03544 315750005636 Interactor of ZYG-11; Region: ZYG-11_interact; pfam05884 315750005637 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 315750005638 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 315750005639 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 315750005640 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 315750005641 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315750005642 ATP binding site [chemical binding]; other site 315750005643 putative Mg++ binding site [ion binding]; other site 315750005644 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315750005645 nucleotide binding region [chemical binding]; other site 315750005646 ATP-binding site [chemical binding]; other site 315750005647 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 315750005648 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 315750005649 putative active site [active] 315750005650 putative FMN binding site [chemical binding]; other site 315750005651 putative substrate binding site [chemical binding]; other site 315750005652 putative catalytic residue [active] 315750005653 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 315750005654 HPr interaction site; other site 315750005655 glycerol kinase (GK) interaction site [polypeptide binding]; other site 315750005656 active site 315750005657 phosphorylation site [posttranslational modification] 315750005658 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 315750005659 YppG-like protein; Region: YppG; pfam14179 315750005660 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 315750005661 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 315750005662 Recombination protein U; Region: RecU; cl01314 315750005663 Transglycosylase; Region: Transgly; cl07896 315750005664 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 315750005665 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315750005666 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 315750005667 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 315750005668 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 315750005669 minor groove reading motif; other site 315750005670 helix-hairpin-helix signature motif; other site 315750005671 substrate binding pocket [chemical binding]; other site 315750005672 active site 315750005673 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 315750005674 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 315750005675 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 315750005676 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 315750005677 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 315750005678 putative dimer interface [polypeptide binding]; other site 315750005679 putative anticodon binding site; other site 315750005680 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 315750005681 homodimer interface [polypeptide binding]; other site 315750005682 motif 1; other site 315750005683 motif 2; other site 315750005684 active site 315750005685 motif 3; other site 315750005686 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 315750005687 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 315750005688 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 315750005689 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 315750005690 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 315750005691 active site 315750005692 catalytic site [active] 315750005693 substrate binding site [chemical binding]; other site 315750005694 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750005695 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750005696 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 315750005697 tetramerization interface [polypeptide binding]; other site 315750005698 active site 315750005699 pantoate--beta-alanine ligase; Region: panC; TIGR00018 315750005700 Pantoate-beta-alanine ligase; Region: PanC; cd00560 315750005701 active site 315750005702 ATP-binding site [chemical binding]; other site 315750005703 pantoate-binding site; other site 315750005704 HXXH motif; other site 315750005705 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 315750005706 oligomerization interface [polypeptide binding]; other site 315750005707 active site 315750005708 metal binding site [ion binding]; metal-binding site 315750005709 Helix-turn-helix domains; Region: HTH; cl00088 315750005710 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 315750005711 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 315750005712 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 315750005713 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 315750005714 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 315750005715 active site 315750005716 NTP binding site [chemical binding]; other site 315750005717 metal binding triad [ion binding]; metal-binding site 315750005718 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 315750005719 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 315750005720 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 315750005721 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 315750005722 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 315750005723 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 315750005724 active site 315750005725 dimer interfaces [polypeptide binding]; other site 315750005726 catalytic residues [active] 315750005727 dihydrodipicolinate reductase; Provisional; Region: PRK00048 315750005728 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750005729 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 315750005730 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 315750005731 homodimer interface [polypeptide binding]; other site 315750005732 metal binding site [ion binding]; metal-binding site 315750005733 Uncharacterized conserved protein [Function unknown]; Region: COG1284 315750005734 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315750005735 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315750005736 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 315750005737 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 315750005738 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 315750005739 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 315750005740 Cytochrome c; Region: Cytochrom_C; cl11414 315750005741 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 315750005742 interchain domain interface [polypeptide binding]; other site 315750005743 intrachain domain interface; other site 315750005744 heme bH binding site [chemical binding]; other site 315750005745 Qi binding site; other site 315750005746 heme bL binding site [chemical binding]; other site 315750005747 Qo binding site; other site 315750005748 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 315750005749 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 315750005750 iron-sulfur cluster [ion binding]; other site 315750005751 [2Fe-2S] cluster binding site [ion binding]; other site 315750005752 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 315750005753 hypothetical protein; Provisional; Region: PRK03636 315750005754 UPF0302 domain; Region: UPF0302; pfam08864 315750005755 IDEAL domain; Region: IDEAL; cl07452 315750005756 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 315750005757 TPR motif; other site 315750005758 binding surface 315750005759 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750005760 binding surface 315750005761 TPR motif; other site 315750005762 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315750005763 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 315750005764 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750005765 binding surface 315750005766 TPR motif; other site 315750005767 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750005768 binding surface 315750005769 TPR motif; other site 315750005770 Tetratricopeptide repeat; Region: TPR_16; pfam13432 315750005771 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 315750005772 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 315750005773 hinge; other site 315750005774 active site 315750005775 prephenate dehydrogenase; Validated; Region: PRK06545 315750005776 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750005777 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 315750005778 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 315750005779 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315750005780 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750005781 homodimer interface [polypeptide binding]; other site 315750005782 catalytic residue [active] 315750005783 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 315750005784 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 315750005785 substrate binding site [chemical binding]; other site 315750005786 active site 315750005787 catalytic residues [active] 315750005788 heterodimer interface [polypeptide binding]; other site 315750005789 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 315750005790 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 315750005791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750005792 catalytic residue [active] 315750005793 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 315750005794 active site 315750005795 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 315750005796 active site 315750005797 ribulose/triose binding site [chemical binding]; other site 315750005798 phosphate binding site [ion binding]; other site 315750005799 substrate (anthranilate) binding pocket [chemical binding]; other site 315750005800 product (indole) binding pocket [chemical binding]; other site 315750005801 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 315750005802 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 315750005803 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 315750005804 anthranilate synthase component I; Provisional; Region: PRK13569 315750005805 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 315750005806 chorismate binding enzyme; Region: Chorismate_bind; cl10555 315750005807 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 315750005808 homotrimer interaction site [polypeptide binding]; other site 315750005809 active site 315750005810 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 315750005811 active site 315750005812 dimer interface [polypeptide binding]; other site 315750005813 metal binding site [ion binding]; metal-binding site 315750005814 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 315750005815 Tetramer interface [polypeptide binding]; other site 315750005816 active site 315750005817 FMN-binding site [chemical binding]; other site 315750005818 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 315750005819 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 315750005820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 315750005821 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 315750005822 active site 315750005823 multimer interface [polypeptide binding]; other site 315750005824 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 315750005825 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 315750005826 substrate binding pocket [chemical binding]; other site 315750005827 chain length determination region; other site 315750005828 substrate-Mg2+ binding site; other site 315750005829 catalytic residues [active] 315750005830 aspartate-rich region 1; other site 315750005831 active site lid residues [active] 315750005832 aspartate-rich region 2; other site 315750005833 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 315750005834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750005835 S-adenosylmethionine binding site [chemical binding]; other site 315750005836 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 315750005837 Tryptophan RNA-binding attenuator protein; Region: TrpBP; cl03437 315750005838 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 315750005839 homodecamer interface [polypeptide binding]; other site 315750005840 GTP cyclohydrolase I; Provisional; Region: PLN03044 315750005841 active site 315750005842 putative catalytic site residues [active] 315750005843 zinc binding site [ion binding]; other site 315750005844 GTP-CH-I/GFRP interaction surface; other site 315750005845 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 315750005846 IHF dimer interface [polypeptide binding]; other site 315750005847 IHF - DNA interface [nucleotide binding]; other site 315750005848 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; cl09772 315750005849 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 315750005850 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 315750005851 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750005852 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 315750005853 GTP-binding protein Der; Reviewed; Region: PRK00093 315750005854 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 315750005855 G1 box; other site 315750005856 GTP/Mg2+ binding site [chemical binding]; other site 315750005857 Switch I region; other site 315750005858 G2 box; other site 315750005859 Switch II region; other site 315750005860 G3 box; other site 315750005861 G4 box; other site 315750005862 G5 box; other site 315750005863 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 315750005864 G1 box; other site 315750005865 GTP/Mg2+ binding site [chemical binding]; other site 315750005866 Switch I region; other site 315750005867 G2 box; other site 315750005868 G3 box; other site 315750005869 Switch II region; other site 315750005870 G4 box; other site 315750005871 G5 box; other site 315750005872 YIEGIA protein; Region: YIEGIA; pfam14045 315750005873 YpzI-like protein; Region: YpzI; pfam14140 315750005874 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 315750005875 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 315750005876 homotetramer interface [polypeptide binding]; other site 315750005877 FMN binding site [chemical binding]; other site 315750005878 homodimer contacts [polypeptide binding]; other site 315750005879 putative active site [active] 315750005880 putative substrate binding site [chemical binding]; other site 315750005881 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 315750005882 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 315750005883 RNA binding site [nucleotide binding]; other site 315750005884 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 315750005885 RNA binding site [nucleotide binding]; other site 315750005886 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 315750005887 RNA binding site [nucleotide binding]; other site 315750005888 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 315750005889 RNA binding site [nucleotide binding]; other site 315750005890 cytidylate kinase; Provisional; Region: cmk; PRK00023 315750005891 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 315750005892 CMP-binding site; other site 315750005893 The sites determining sugar specificity; other site 315750005894 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 315750005895 Flagellar protein YcgR; Region: YcgR_2; pfam12945 315750005896 PilZ domain; Region: PilZ; cl01260 315750005897 germination protein YpeB; Region: spore_YpeB; TIGR02889 315750005898 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 315750005899 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 315750005900 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 315750005901 Protease prsW family; Region: PrsW-protease; cl15823 315750005902 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 315750005903 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750005904 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315750005905 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 315750005906 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 315750005907 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 315750005908 NAD(P) binding site [chemical binding]; other site 315750005909 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 315750005910 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 315750005911 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 315750005912 putative active site [active] 315750005913 putative metal binding site [ion binding]; other site 315750005914 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 315750005915 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 315750005916 CAAX protease self-immunity; Region: Abi; cl00558 315750005917 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 315750005918 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315750005919 ATP binding site [chemical binding]; other site 315750005920 putative Mg++ binding site [ion binding]; other site 315750005921 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315750005922 nucleotide binding region [chemical binding]; other site 315750005923 ATP-binding site [chemical binding]; other site 315750005924 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 315750005925 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 315750005926 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 315750005927 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 315750005928 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750005929 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 315750005930 putative L-serine binding site [chemical binding]; other site 315750005931 Peptidase family M23; Region: Peptidase_M23; pfam01551 315750005932 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 315750005933 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 315750005934 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 315750005935 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315750005936 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315750005937 DNA binding residues [nucleotide binding] 315750005938 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 315750005939 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315750005940 dimerization interface [polypeptide binding]; other site 315750005941 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 315750005942 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315750005943 dimer interface [polypeptide binding]; other site 315750005944 phosphorylation site [posttranslational modification] 315750005945 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750005946 ATP binding site [chemical binding]; other site 315750005947 Mg2+ binding site [ion binding]; other site 315750005948 G-X-G motif; other site 315750005949 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315750005950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750005951 active site 315750005952 phosphorylation site [posttranslational modification] 315750005953 intermolecular recognition site; other site 315750005954 dimerization interface [polypeptide binding]; other site 315750005955 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315750005956 DNA binding site [nucleotide binding] 315750005957 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 315750005958 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 315750005959 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 315750005960 ResB-like family; Region: ResB; pfam05140 315750005961 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 315750005962 catalytic residues [active] 315750005963 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 315750005964 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315750005965 RNA binding surface [nucleotide binding]; other site 315750005966 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 315750005967 active site 315750005968 Nucleoside recognition; Region: Gate; cl00486 315750005969 Nucleoside recognition; Region: Gate; cl00486 315750005970 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 315750005971 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315750005972 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 315750005973 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 315750005974 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 315750005975 ScpA/B protein; Region: ScpA_ScpB; cl00598 315750005976 Domain of unknown function (DUF309); Region: DUF309; cl00667 315750005977 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750005978 Coenzyme A binding pocket [chemical binding]; other site 315750005979 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 315750005980 homopentamer interface [polypeptide binding]; other site 315750005981 active site 315750005982 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 315750005983 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 315750005984 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 315750005985 Lumazine binding domain; Region: Lum_binding; pfam00677 315750005986 Lumazine binding domain; Region: Lum_binding; pfam00677 315750005987 Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278 315750005988 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750005989 Helix-turn-helix domains; Region: HTH; cl00088 315750005990 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 315750005991 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750005992 putative substrate translocation pore; other site 315750005993 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 315750005994 active site 315750005995 Predicted secreted protein [Function unknown]; Region: COG4086 315750005996 diaminopimelate decarboxylase; Region: lysA; TIGR01048 315750005997 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 315750005998 active site 315750005999 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 315750006000 substrate binding site [chemical binding]; other site 315750006001 catalytic residues [active] 315750006002 dimer interface [polypeptide binding]; other site 315750006003 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 315750006004 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 315750006005 SpoVA protein; Region: SpoVA; cl04298 315750006006 stage V sporulation protein AD; Validated; Region: PRK08304 315750006007 stage V sporulation protein AD; Provisional; Region: PRK12404 315750006008 SpoVA protein; Region: SpoVA; cl04298 315750006009 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 315750006010 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 315750006011 sporulation sigma factor SigF; Validated; Region: PRK05572 315750006012 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315750006013 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 315750006014 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315750006015 DNA binding residues [nucleotide binding] 315750006016 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 315750006017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750006018 ATP binding site [chemical binding]; other site 315750006019 Mg2+ binding site [ion binding]; other site 315750006020 G-X-G motif; other site 315750006021 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 315750006022 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 315750006023 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315750006024 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 315750006025 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 315750006026 Sulfatase; Region: Sulfatase; cl10460 315750006027 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 315750006028 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 315750006029 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 315750006030 active site 315750006031 Int/Topo IB signature motif; other site 315750006032 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 315750006033 ferric uptake regulator; Provisional; Region: fur; PRK09462 315750006034 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 315750006035 metal binding site 2 [ion binding]; metal-binding site 315750006036 putative DNA binding helix; other site 315750006037 metal binding site 1 [ion binding]; metal-binding site 315750006038 dimer interface [polypeptide binding]; other site 315750006039 structural Zn2+ binding site [ion binding]; other site 315750006040 Integral membrane protein DUF95; Region: DUF95; cl00572 315750006041 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315750006042 TIGR00375 family protein; Region: TIGR00375 315750006043 PHP-associated; Region: PHP_C; pfam13263 315750006044 Y-family of DNA polymerases; Region: PolY; cl12025 315750006045 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 315750006046 dimer interface [polypeptide binding]; other site 315750006047 ADP-ribose binding site [chemical binding]; other site 315750006048 active site 315750006049 nudix motif; other site 315750006050 metal binding site [ion binding]; metal-binding site 315750006051 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 315750006052 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 315750006053 active site 315750006054 catalytic tetrad [active] 315750006055 TMAO/DMSO reductase; Reviewed; Region: PRK05363 315750006056 Bacillus cereus group antimicrobial protein; Region: lci; pfam12197 315750006057 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315750006058 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 315750006059 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315750006060 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315750006061 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 315750006062 TPR motif; other site 315750006063 binding surface 315750006064 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 315750006065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 315750006066 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750006067 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315750006068 Coenzyme A binding pocket [chemical binding]; other site 315750006069 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 315750006070 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 315750006071 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750006072 Coenzyme A binding pocket [chemical binding]; other site 315750006073 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 315750006074 DNA polymerase IV; Reviewed; Region: PRK03103 315750006075 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 315750006076 active site 315750006077 DNA binding site [nucleotide binding] 315750006078 YolD-like protein; Region: YolD; pfam08863 315750006079 putative transporter; Provisional; Region: PRK10054 315750006080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750006081 putative substrate translocation pore; other site 315750006082 pantothenate kinase; Provisional; Region: PRK05439 315750006083 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 315750006084 ATP-binding site [chemical binding]; other site 315750006085 CoA-binding site [chemical binding]; other site 315750006086 Mg2+-binding site [ion binding]; other site 315750006087 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 315750006088 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315750006089 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 315750006090 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 315750006091 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750006092 NAD(P) binding site [chemical binding]; other site 315750006093 active site 315750006094 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315750006095 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750006096 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 315750006097 Bacillus cereus group antimicrobial protein; Region: lci; pfam12197 315750006098 Arginine degradation protein (predicted deacylase) [Amino acid transport and metabolism]; Region: RocB; COG4187 315750006099 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 315750006100 putative metal binding site [ion binding]; other site 315750006101 putative dimer interface [polypeptide binding]; other site 315750006102 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 315750006103 active site 315750006104 FMN binding site [chemical binding]; other site 315750006105 substrate binding site [chemical binding]; other site 315750006106 homotetramer interface [polypeptide binding]; other site 315750006107 catalytic residue [active] 315750006108 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315750006109 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315750006110 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 315750006111 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750006112 homodimer interface [polypeptide binding]; other site 315750006113 catalytic residue [active] 315750006114 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315750006115 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 315750006116 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 315750006117 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 315750006118 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 315750006119 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315750006120 DNA-binding site [nucleotide binding]; DNA binding site 315750006121 UTRA domain; Region: UTRA; cl01230 315750006122 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 315750006123 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 315750006124 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 315750006125 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 315750006126 active site 315750006127 methionine cluster; other site 315750006128 phosphorylation site [posttranslational modification] 315750006129 metal binding site [ion binding]; metal-binding site 315750006130 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 315750006131 active site 315750006132 P-loop; other site 315750006133 phosphorylation site [posttranslational modification] 315750006134 glucose-1-dehydrogenase; Provisional; Region: PRK08936 315750006135 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 315750006136 NAD binding site [chemical binding]; other site 315750006137 homodimer interface [polypeptide binding]; other site 315750006138 active site 315750006139 Sugar transport protein; Region: Sugar_transport; pfam06800 315750006140 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750006141 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 315750006142 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 315750006143 DNA polymerase IV; Validated; Region: PRK01810 315750006144 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 315750006145 active site 315750006146 DNA binding site [nucleotide binding] 315750006147 Predicted amidohydrolase [General function prediction only]; Region: COG0388 315750006148 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 315750006149 putative active site [active] 315750006150 catalytic triad [active] 315750006151 putative dimer interface [polypeptide binding]; other site 315750006152 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 315750006153 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 315750006154 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 315750006155 peptidase T-like protein; Region: PepT-like; TIGR01883 315750006156 metal binding site [ion binding]; metal-binding site 315750006157 putative dimer interface [polypeptide binding]; other site 315750006158 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 315750006159 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 315750006160 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 315750006161 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315750006162 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 315750006163 dimer interface [polypeptide binding]; other site 315750006164 substrate binding site [chemical binding]; other site 315750006165 metal binding site [ion binding]; metal-binding site 315750006166 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 315750006167 Predicted membrane protein [Function unknown]; Region: COG4129 315750006168 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 315750006169 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 315750006170 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 315750006171 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 315750006172 Walker A/P-loop; other site 315750006173 ATP binding site [chemical binding]; other site 315750006174 Q-loop/lid; other site 315750006175 ABC transporter signature motif; other site 315750006176 Walker B; other site 315750006177 D-loop; other site 315750006178 H-loop/switch region; other site 315750006179 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 315750006180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750006181 dimer interface [polypeptide binding]; other site 315750006182 conserved gate region; other site 315750006183 putative PBP binding loops; other site 315750006184 ABC-ATPase subunit interface; other site 315750006185 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 315750006186 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 315750006187 substrate binding pocket [chemical binding]; other site 315750006188 membrane-bound complex binding site; other site 315750006189 hinge residues; other site 315750006190 Disulphide isomerase; Region: Disulph_isomer; cl05813 315750006191 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 315750006192 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 315750006193 YesK-like protein; Region: YesK; pfam14150 315750006194 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 315750006195 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 315750006196 E3 interaction surface; other site 315750006197 lipoyl attachment site [posttranslational modification]; other site 315750006198 e3 binding domain; Region: E3_binding; pfam02817 315750006199 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 315750006200 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 315750006201 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 315750006202 alpha subunit interface [polypeptide binding]; other site 315750006203 TPP binding site [chemical binding]; other site 315750006204 heterodimer interface [polypeptide binding]; other site 315750006205 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 315750006206 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 315750006207 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 315750006208 tetramer interface [polypeptide binding]; other site 315750006209 TPP-binding site [chemical binding]; other site 315750006210 heterodimer interface [polypeptide binding]; other site 315750006211 phosphorylation loop region [posttranslational modification] 315750006212 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 315750006213 glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Region: glycerol3P_GlpB; TIGR03378 315750006214 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315750006215 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 315750006216 Acetokinase family; Region: Acetate_kinase; cl01029 315750006217 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 315750006218 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 315750006219 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 315750006220 NAD binding site [chemical binding]; other site 315750006221 Phe binding site; other site 315750006222 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 315750006223 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 315750006224 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 315750006225 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315750006226 putative active site [active] 315750006227 heme pocket [chemical binding]; other site 315750006228 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 315750006229 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750006230 Walker A motif; other site 315750006231 ATP binding site [chemical binding]; other site 315750006232 Walker B motif; other site 315750006233 arginine finger; other site 315750006234 Helix-turn-helix domains; Region: HTH; cl00088 315750006235 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 315750006236 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 315750006237 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 315750006238 active site 315750006239 catalytic site [active] 315750006240 metal binding site [ion binding]; metal-binding site 315750006241 dimer interface [polypeptide binding]; other site 315750006242 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 315750006243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750006244 active site 315750006245 phosphorylation site [posttranslational modification] 315750006246 intermolecular recognition site; other site 315750006247 dimerization interface [polypeptide binding]; other site 315750006248 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 315750006249 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 315750006250 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 315750006251 protein binding site [polypeptide binding]; other site 315750006252 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 315750006253 DNA repair protein RecN; Region: recN; TIGR00634 315750006254 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 315750006255 Walker A/P-loop; other site 315750006256 ATP binding site [chemical binding]; other site 315750006257 Q-loop/lid; other site 315750006258 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 315750006259 ABC transporter signature motif; other site 315750006260 Walker B; other site 315750006261 D-loop; other site 315750006262 H-loop/switch region; other site 315750006263 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 315750006264 arginine repressor; Provisional; Region: PRK04280 315750006265 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 315750006266 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 315750006267 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315750006268 RNA binding surface [nucleotide binding]; other site 315750006269 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 315750006270 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 315750006271 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 315750006272 TPP-binding site; other site 315750006273 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 315750006274 PYR/PP interface [polypeptide binding]; other site 315750006275 dimer interface [polypeptide binding]; other site 315750006276 TPP binding site [chemical binding]; other site 315750006277 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 315750006278 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 315750006279 substrate binding pocket [chemical binding]; other site 315750006280 chain length determination region; other site 315750006281 substrate-Mg2+ binding site; other site 315750006282 catalytic residues [active] 315750006283 aspartate-rich region 1; other site 315750006284 active site lid residues [active] 315750006285 aspartate-rich region 2; other site 315750006286 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 315750006287 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 315750006288 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 315750006289 generic binding surface II; other site 315750006290 generic binding surface I; other site 315750006291 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 315750006292 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 315750006293 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 315750006294 homodimer interface [polypeptide binding]; other site 315750006295 NADP binding site [chemical binding]; other site 315750006296 substrate binding site [chemical binding]; other site 315750006297 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 315750006298 putative RNA binding site [nucleotide binding]; other site 315750006299 Asp23 family; Region: Asp23; cl00574 315750006300 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 315750006301 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 315750006302 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 315750006303 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 315750006304 carboxyltransferase (CT) interaction site; other site 315750006305 biotinylation site [posttranslational modification]; other site 315750006306 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 315750006307 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 315750006308 stage III sporulation protein AF; Region: spore_III_AF; TIGR02896 315750006309 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 315750006310 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 315750006311 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 315750006312 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 315750006313 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 315750006314 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 315750006315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750006316 Walker A motif; other site 315750006317 ATP binding site [chemical binding]; other site 315750006318 Walker B motif; other site 315750006319 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 315750006320 elongation factor P; Validated; Region: PRK00529 315750006321 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 315750006322 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 315750006323 RNA binding site [nucleotide binding]; other site 315750006324 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 315750006325 RNA binding site [nucleotide binding]; other site 315750006326 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 315750006327 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 315750006328 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 315750006329 active site 315750006330 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 315750006331 trimer interface [polypeptide binding]; other site 315750006332 active site 315750006333 dimer interface [polypeptide binding]; other site 315750006334 Conserved membrane protein YqhR; Region: YqhR; pfam11085 315750006335 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 315750006336 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 315750006337 manganese transport transcriptional regulator; Provisional; Region: PRK03902 315750006338 Helix-turn-helix domains; Region: HTH; cl00088 315750006339 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 315750006340 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 315750006341 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 315750006342 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 315750006343 active site residue [active] 315750006344 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 315750006345 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 315750006346 tetramer interface [polypeptide binding]; other site 315750006347 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750006348 catalytic residue [active] 315750006349 glycine dehydrogenase subunit 1; Validated; Region: PRK00451 315750006350 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 315750006351 tetramer interface [polypeptide binding]; other site 315750006352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750006353 catalytic residue [active] 315750006354 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 315750006355 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 315750006356 DEAD-like helicases superfamily; Region: DEXDc; smart00487 315750006357 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315750006358 ATP binding site [chemical binding]; other site 315750006359 putative Mg++ binding site [ion binding]; other site 315750006360 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315750006361 nucleotide binding region [chemical binding]; other site 315750006362 ATP-binding site [chemical binding]; other site 315750006363 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 315750006364 Anti-repressor SinI; Region: SinI; pfam08671 315750006365 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315750006366 non-specific DNA binding site [nucleotide binding]; other site 315750006367 salt bridge; other site 315750006368 sequence-specific DNA binding site [nucleotide binding]; other site 315750006369 Anti-repressor SinI; Region: SinI; pfam08671 315750006370 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 315750006371 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 315750006372 Catalytic site [active] 315750006373 YqxM protein; Region: YqxM_for_SipW; TIGR04087 315750006374 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 315750006375 YqzE-like protein; Region: YqzE; pfam14038 315750006376 ComG operon protein 7; Region: ComGG; pfam14173 315750006377 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 315750006378 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 315750006379 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 315750006380 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 315750006381 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 315750006382 Type II/IV secretion system protein; Region: T2SE; pfam00437 315750006383 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750006384 Walker A motif; other site 315750006385 ATP binding site [chemical binding]; other site 315750006386 Walker B motif; other site 315750006387 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 315750006388 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 315750006389 ArsC family; Region: ArsC; pfam03960 315750006390 putative catalytic residues [active] 315750006391 thiol/disulfide switch; other site 315750006392 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 315750006393 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315750006394 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 315750006395 Domain of unknown function DUF77; Region: DUF77; cl00307 315750006396 H+ Antiporter protein; Region: 2A0121; TIGR00900 315750006397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750006398 putative substrate translocation pore; other site 315750006399 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 315750006400 active site 315750006401 Zn binding site [ion binding]; other site 315750006402 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 315750006403 Sulfatase; Region: Sulfatase; cl10460 315750006404 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 315750006405 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 315750006406 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 315750006407 Rhomboid family; Region: Rhomboid; cl11446 315750006408 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750006409 binding surface 315750006410 Tetratricopeptide repeat; Region: TPR_16; pfam13432 315750006411 TPR motif; other site 315750006412 Tetratricopeptide repeat; Region: TPR_16; pfam13432 315750006413 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 315750006414 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 315750006415 proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675 315750006416 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274 315750006417 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 315750006418 Walker A/P-loop; other site 315750006419 ATP binding site [chemical binding]; other site 315750006420 Q-loop/lid; other site 315750006421 ABC transporter signature motif; other site 315750006422 Walker B; other site 315750006423 D-loop; other site 315750006424 H-loop/switch region; other site 315750006425 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248 315750006426 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 315750006427 Walker A/P-loop; other site 315750006428 ATP binding site [chemical binding]; other site 315750006429 Q-loop/lid; other site 315750006430 ABC transporter signature motif; other site 315750006431 Walker B; other site 315750006432 D-loop; other site 315750006433 H-loop/switch region; other site 315750006434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750006435 dimer interface [polypeptide binding]; other site 315750006436 conserved gate region; other site 315750006437 putative PBP binding loops; other site 315750006438 ABC-ATPase subunit interface; other site 315750006439 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 315750006440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750006441 dimer interface [polypeptide binding]; other site 315750006442 conserved gate region; other site 315750006443 putative PBP binding loops; other site 315750006444 ABC-ATPase subunit interface; other site 315750006445 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 315750006446 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 315750006447 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 315750006448 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315750006449 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315750006450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750006451 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315750006452 putative substrate translocation pore; other site 315750006453 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 315750006454 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 315750006455 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 315750006456 Protein of unknown function (DUF456); Region: DUF456; cl01069 315750006457 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 315750006458 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315750006459 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315750006460 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 315750006461 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 315750006462 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 315750006463 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 315750006464 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 315750006465 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 315750006466 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 315750006467 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 315750006468 metal binding site 2 [ion binding]; metal-binding site 315750006469 putative DNA binding helix; other site 315750006470 metal binding site 1 [ion binding]; metal-binding site 315750006471 dimer interface [polypeptide binding]; other site 315750006472 structural Zn2+ binding site [ion binding]; other site 315750006473 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315750006474 ABC-ATPase subunit interface; other site 315750006475 dimer interface [polypeptide binding]; other site 315750006476 putative PBP binding regions; other site 315750006477 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 315750006478 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 315750006479 Uncharacterized conserved protein [Function unknown]; Region: COG1284 315750006480 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315750006481 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 315750006482 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 315750006483 endonuclease IV; Provisional; Region: PRK01060 315750006484 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 315750006485 AP (apurinic/apyrimidinic) site pocket; other site 315750006486 DNA interaction; other site 315750006487 Metal-binding active site; metal-binding site 315750006488 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 315750006489 DEAD-like helicases superfamily; Region: DEXDc; smart00487 315750006490 ATP binding site [chemical binding]; other site 315750006491 Mg++ binding site [ion binding]; other site 315750006492 motif III; other site 315750006493 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315750006494 nucleotide binding region [chemical binding]; other site 315750006495 ATP-binding site [chemical binding]; other site 315750006496 YqfQ-like protein; Region: YqfQ; pfam14181 315750006497 LytB protein; Region: LYTB; cl00507 315750006498 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 315750006499 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 315750006500 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 315750006501 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 315750006502 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 315750006503 Cytochrome c; Region: Cytochrom_C; cl11414 315750006504 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 315750006505 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 315750006506 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 315750006507 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315750006508 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 315750006509 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315750006510 DNA binding residues [nucleotide binding] 315750006511 DNA primase; Validated; Region: dnaG; PRK05667 315750006512 CHC2 zinc finger; Region: zf-CHC2; cl15369 315750006513 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 315750006514 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 315750006515 active site 315750006516 metal binding site [ion binding]; metal-binding site 315750006517 interdomain interaction site; other site 315750006518 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 315750006519 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 315750006520 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 315750006521 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 315750006522 Helix-turn-helix domains; Region: HTH; cl00088 315750006523 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 315750006524 FOG: CBS domain [General function prediction only]; Region: COG0517 315750006525 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 315750006526 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 315750006527 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 315750006528 dimer interface [polypeptide binding]; other site 315750006529 motif 1; other site 315750006530 active site 315750006531 motif 2; other site 315750006532 motif 3; other site 315750006533 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 315750006534 Recombination protein O N terminal; Region: RecO_N; cl15812 315750006535 Recombination protein O C terminal; Region: RecO_C; pfam02565 315750006536 YqzL-like protein; Region: YqzL; pfam14006 315750006537 GTPase Era; Reviewed; Region: era; PRK00089 315750006538 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 315750006539 G1 box; other site 315750006540 GTP/Mg2+ binding site [chemical binding]; other site 315750006541 Switch I region; other site 315750006542 G2 box; other site 315750006543 Switch II region; other site 315750006544 G3 box; other site 315750006545 G4 box; other site 315750006546 G5 box; other site 315750006547 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 315750006548 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 315750006549 active site 315750006550 catalytic motif [active] 315750006551 Zn binding site [ion binding]; other site 315750006552 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 315750006553 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 315750006554 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 315750006555 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 315750006556 Zn2+ binding site [ion binding]; other site 315750006557 Mg2+ binding site [ion binding]; other site 315750006558 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 315750006559 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750006560 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 315750006561 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 315750006562 YabP family; Region: YabP; cl06766 315750006563 RES domain; Region: RES; cl02411 315750006564 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 315750006565 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 315750006566 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 315750006567 dimer interface [polypeptide binding]; other site 315750006568 active site residues [active] 315750006569 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 315750006570 GatB domain; Region: GatB_Yqey; cl11497 315750006571 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 315750006572 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 315750006573 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 315750006574 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 315750006575 radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089 315750006576 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 315750006577 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315750006578 FeS/SAM binding site; other site 315750006579 TRAM domain; Region: TRAM; cl01282 315750006580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 315750006581 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 315750006582 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 315750006583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750006584 S-adenosylmethionine binding site [chemical binding]; other site 315750006585 chaperone protein DnaJ; Provisional; Region: PRK14280 315750006586 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 315750006587 HSP70 interaction site [polypeptide binding]; other site 315750006588 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 315750006589 substrate binding site [polypeptide binding]; other site 315750006590 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 315750006591 Zn binding sites [ion binding]; other site 315750006592 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 315750006593 dimer interface [polypeptide binding]; other site 315750006594 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 315750006595 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 315750006596 dimer interface [polypeptide binding]; other site 315750006597 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 315750006598 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 315750006599 Helix-turn-helix domains; Region: HTH; cl00088 315750006600 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 315750006601 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315750006602 FeS/SAM binding site; other site 315750006603 HemN C-terminal domain; Region: HemN_C; pfam06969 315750006604 GTP-binding protein LepA; Provisional; Region: PRK05433 315750006605 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 315750006606 G1 box; other site 315750006607 putative GEF interaction site [polypeptide binding]; other site 315750006608 GTP/Mg2+ binding site [chemical binding]; other site 315750006609 Switch I region; other site 315750006610 G2 box; other site 315750006611 G3 box; other site 315750006612 Switch II region; other site 315750006613 G4 box; other site 315750006614 G5 box; other site 315750006615 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 315750006616 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 315750006617 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 315750006618 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 315750006619 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 315750006620 stage II sporulation protein P; Region: spore_II_P; TIGR02867 315750006621 Germination protease; Region: Peptidase_A25; cl04057 315750006622 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 315750006623 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 315750006624 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 315750006625 YqzM-like protein; Region: YqzM; pfam14141 315750006626 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 315750006627 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 315750006628 Competence protein; Region: Competence; cl00471 315750006629 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315750006630 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 315750006631 catalytic motif [active] 315750006632 Zn binding site [ion binding]; other site 315750006633 SLBB domain; Region: SLBB; pfam10531 315750006634 comEA protein; Region: comE; TIGR01259 315750006635 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 315750006636 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750006637 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 315750006638 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 315750006639 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750006640 S-adenosylmethionine binding site [chemical binding]; other site 315750006641 Oligomerisation domain; Region: Oligomerisation; cl00519 315750006642 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 315750006643 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 315750006644 Zn2+ binding site [ion binding]; other site 315750006645 Mg2+ binding site [ion binding]; other site 315750006646 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 315750006647 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 315750006648 active site 315750006649 (T/H)XGH motif; other site 315750006650 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 315750006651 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 315750006652 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 315750006653 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 315750006654 shikimate binding site; other site 315750006655 NAD(P) binding site [chemical binding]; other site 315750006656 GTPase YqeH; Provisional; Region: PRK13796 315750006657 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 315750006658 GTP/Mg2+ binding site [chemical binding]; other site 315750006659 G4 box; other site 315750006660 G5 box; other site 315750006661 G1 box; other site 315750006662 Switch I region; other site 315750006663 G2 box; other site 315750006664 G3 box; other site 315750006665 Switch II region; other site 315750006666 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750006667 motif II; other site 315750006668 Sporulation inhibitor A; Region: Sda; pfam08970 315750006669 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 315750006670 active site 315750006671 catalytic triad [active] 315750006672 oxyanion hole [active] 315750006673 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 315750006674 NodB motif; other site 315750006675 putative active site [active] 315750006676 putative catalytic site [active] 315750006677 putative Zn binding site [ion binding]; other site 315750006678 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315750006679 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 315750006680 binding surface 315750006681 TPR motif; other site 315750006682 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315750006683 sporulation sigma factor SigK; Reviewed; Region: PRK05803 315750006684 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315750006685 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315750006686 DNA binding residues [nucleotide binding] 315750006687 Transposase domain (DUF772); Region: DUF772; pfam05598 315750006688 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 315750006689 DDE superfamily endonuclease; Region: DDE_4; cl15789 315750006690 Immunity protein Imm6; Region: Imm6; pfam14434 315750006691 Domain of unknown function (DUF955); Region: DUF955; cl01076 315750006692 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 315750006693 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 315750006694 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 315750006695 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 315750006696 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750006697 Coenzyme A binding pocket [chemical binding]; other site 315750006698 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 315750006699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750006700 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 315750006701 putative substrate translocation pore; other site 315750006702 L-arabinose isomerase; Provisional; Region: PRK02929 315750006703 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 315750006704 hexamer (dimer of trimers) interface [polypeptide binding]; other site 315750006705 trimer interface [polypeptide binding]; other site 315750006706 substrate binding site [chemical binding]; other site 315750006707 Mn binding site [ion binding]; other site 315750006708 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 315750006709 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 315750006710 intersubunit interface [polypeptide binding]; other site 315750006711 active site 315750006712 Zn2+ binding site [ion binding]; other site 315750006713 L-ribulokinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 315750006714 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 315750006715 putative N- and C-terminal domain interface [polypeptide binding]; other site 315750006716 putative active site [active] 315750006717 putative MgATP binding site [chemical binding]; other site 315750006718 catalytic site [active] 315750006719 metal binding site [ion binding]; metal-binding site 315750006720 putative carbohydrate binding site [chemical binding]; other site 315750006721 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315750006722 DNA-binding site [nucleotide binding]; DNA binding site 315750006723 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 315750006724 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 315750006725 putative dimerization interface [polypeptide binding]; other site 315750006726 putative ligand binding site [chemical binding]; other site 315750006727 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 315750006728 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 315750006729 catalytic residues [active] 315750006730 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 315750006731 tetramer interface [polypeptide binding]; other site 315750006732 Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane]; Region: GutQ; COG0794 315750006733 active site 315750006734 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 315750006735 active site 315750006736 dimer interface [polypeptide binding]; other site 315750006737 magnesium binding site [ion binding]; other site 315750006738 Helix-turn-helix domains; Region: HTH; cl00088 315750006739 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315750006740 substrate binding pocket [chemical binding]; other site 315750006741 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315750006742 YxiJ-like protein; Region: YxiJ; pfam14176 315750006743 RHS Repeat; Region: RHS_repeat; cl11982 315750006744 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 315750006745 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 315750006746 RHS Repeat; Region: RHS_repeat; cl11982 315750006747 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 315750006748 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315750006749 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 315750006750 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 315750006751 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 315750006752 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 315750006753 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 315750006754 Walker A/P-loop; other site 315750006755 ATP binding site [chemical binding]; other site 315750006756 Q-loop/lid; other site 315750006757 ABC transporter signature motif; other site 315750006758 Walker B; other site 315750006759 D-loop; other site 315750006760 H-loop/switch region; other site 315750006761 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 315750006762 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 315750006763 substrate binding pocket [chemical binding]; other site 315750006764 membrane-bound complex binding site; other site 315750006765 hinge residues; other site 315750006766 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 315750006767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750006768 dimer interface [polypeptide binding]; other site 315750006769 conserved gate region; other site 315750006770 putative PBP binding loops; other site 315750006771 ABC-ATPase subunit interface; other site 315750006772 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 315750006773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750006774 dimer interface [polypeptide binding]; other site 315750006775 conserved gate region; other site 315750006776 putative PBP binding loops; other site 315750006777 ABC-ATPase subunit interface; other site 315750006778 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 315750006779 dimanganese center [ion binding]; other site 315750006780 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 315750006781 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 315750006782 putative NAD(P) binding site [chemical binding]; other site 315750006783 catalytic Zn binding site [ion binding]; other site 315750006784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750006785 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315750006786 putative substrate translocation pore; other site 315750006787 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 315750006788 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750006789 NAD(P) binding site [chemical binding]; other site 315750006790 active site 315750006791 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 315750006792 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 315750006793 active site 315750006794 metal binding site [ion binding]; metal-binding site 315750006795 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 315750006796 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 315750006797 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315750006798 Helix-turn-helix domains; Region: HTH; cl00088 315750006799 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315750006800 dimerization interface [polypeptide binding]; other site 315750006801 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 315750006802 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 315750006803 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750006804 Walker A/P-loop; other site 315750006805 ATP binding site [chemical binding]; other site 315750006806 Q-loop/lid; other site 315750006807 ABC transporter signature motif; other site 315750006808 Walker B; other site 315750006809 D-loop; other site 315750006810 H-loop/switch region; other site 315750006811 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315750006812 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 315750006813 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 315750006814 NAD binding site [chemical binding]; other site 315750006815 catalytic Zn binding site [ion binding]; other site 315750006816 structural Zn binding site [ion binding]; other site 315750006817 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750006818 S-adenosylmethionine binding site [chemical binding]; other site 315750006819 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 315750006820 YrhC-like protein; Region: YrhC; pfam14143 315750006821 cystathionine beta-lyase; Provisional; Region: PRK07671 315750006822 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 315750006823 homodimer interface [polypeptide binding]; other site 315750006824 substrate-cofactor binding pocket; other site 315750006825 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750006826 catalytic residue [active] 315750006827 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 315750006828 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 315750006829 dimer interface [polypeptide binding]; other site 315750006830 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750006831 catalytic residue [active] 315750006832 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 315750006833 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 315750006834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 315750006835 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 315750006836 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 315750006837 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 315750006838 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315750006839 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315750006840 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 315750006841 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 315750006842 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 315750006843 Transposase domain (DUF772); Region: DUF772; pfam05598 315750006844 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 315750006845 DDE superfamily endonuclease; Region: DDE_4; cl15789 315750006846 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 315750006847 ATP-binding site [chemical binding]; other site 315750006848 Sugar specificity; other site 315750006849 Pyrimidine base specificity; other site 315750006850 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 315750006851 Peptidase family U32; Region: Peptidase_U32; cl03113 315750006852 Peptidase family U32; Region: Peptidase_U32; cl03113 315750006853 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 315750006854 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750006855 S-adenosylmethionine binding site [chemical binding]; other site 315750006856 YceG-like family; Region: YceG; pfam02618 315750006857 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 315750006858 dimerization interface [polypeptide binding]; other site 315750006859 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 315750006860 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 315750006861 dimer interface [polypeptide binding]; other site 315750006862 active site 315750006863 acyl-CoA synthetase; Validated; Region: PRK07638 315750006864 AMP-binding enzyme; Region: AMP-binding; cl15778 315750006865 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 315750006866 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 315750006867 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 315750006868 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 315750006869 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 315750006870 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 315750006871 motif 1; other site 315750006872 active site 315750006873 motif 2; other site 315750006874 motif 3; other site 315750006875 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 315750006876 DHHA1 domain; Region: DHHA1; pfam02272 315750006877 Domain of unknown function DUF20; Region: UPF0118; pfam01594 315750006878 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 315750006879 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 315750006880 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 315750006881 Walker A/P-loop; other site 315750006882 ATP binding site [chemical binding]; other site 315750006883 Q-loop/lid; other site 315750006884 ABC transporter signature motif; other site 315750006885 Walker B; other site 315750006886 D-loop; other site 315750006887 H-loop/switch region; other site 315750006888 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 315750006889 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 315750006890 substrate binding pocket [chemical binding]; other site 315750006891 membrane-bound complex binding site; other site 315750006892 hinge residues; other site 315750006893 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 315750006894 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750006895 dimer interface [polypeptide binding]; other site 315750006896 conserved gate region; other site 315750006897 putative PBP binding loops; other site 315750006898 ABC-ATPase subunit interface; other site 315750006899 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 315750006900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750006901 dimer interface [polypeptide binding]; other site 315750006902 conserved gate region; other site 315750006903 putative PBP binding loops; other site 315750006904 ABC-ATPase subunit interface; other site 315750006905 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 315750006906 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 315750006907 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750006908 Family description; Region: UvrD_C_2; cl15862 315750006909 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750006910 binding surface 315750006911 TPR motif; other site 315750006912 TPR repeat; Region: TPR_11; pfam13414 315750006913 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750006914 binding surface 315750006915 TPR motif; other site 315750006916 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 315750006917 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 315750006918 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 315750006919 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 315750006920 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 315750006921 catalytic residue [active] 315750006922 Predicted transcriptional regulator [Transcription]; Region: COG1959 315750006923 Helix-turn-helix domains; Region: HTH; cl00088 315750006924 recombination factor protein RarA; Reviewed; Region: PRK13342 315750006925 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750006926 Walker A motif; other site 315750006927 ATP binding site [chemical binding]; other site 315750006928 Walker B motif; other site 315750006929 arginine finger; other site 315750006930 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 315750006931 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 315750006932 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 315750006933 putative ATP binding site [chemical binding]; other site 315750006934 putative substrate interface [chemical binding]; other site 315750006935 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 315750006936 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 315750006937 dimer interface [polypeptide binding]; other site 315750006938 anticodon binding site; other site 315750006939 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 315750006940 homodimer interface [polypeptide binding]; other site 315750006941 motif 1; other site 315750006942 active site 315750006943 motif 2; other site 315750006944 GAD domain; Region: GAD; pfam02938 315750006945 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 315750006946 motif 3; other site 315750006947 histidyl-tRNA synthetase; Region: hisS; TIGR00442 315750006948 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 315750006949 dimer interface [polypeptide binding]; other site 315750006950 motif 1; other site 315750006951 active site 315750006952 motif 2; other site 315750006953 motif 3; other site 315750006954 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 315750006955 Bacterial SH3 domain; Region: SH3_3; cl02551 315750006956 Bacterial SH3 domain; Region: SH3_3; cl02551 315750006957 Bacterial SH3 domain; Region: SH3_3; cl02551 315750006958 Bacterial SH3 domain; Region: SH3_3; cl02551 315750006959 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 315750006960 active site 315750006961 metal binding site [ion binding]; metal-binding site 315750006962 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 315750006963 putative active site [active] 315750006964 dimerization interface [polypeptide binding]; other site 315750006965 putative tRNAtyr binding site [nucleotide binding]; other site 315750006966 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 315750006967 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 315750006968 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 315750006969 synthetase active site [active] 315750006970 NTP binding site [chemical binding]; other site 315750006971 metal binding site [ion binding]; metal-binding site 315750006972 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 315750006973 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 315750006974 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315750006975 active site 315750006976 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 315750006977 DHH family; Region: DHH; pfam01368 315750006978 DHHA1 domain; Region: DHHA1; pfam02272 315750006979 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 315750006980 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 315750006981 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 315750006982 Protein export membrane protein; Region: SecD_SecF; cl14618 315750006983 Protein export membrane protein; Region: SecD_SecF; cl14618 315750006984 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 315750006985 stage V sporulation protein B; Region: spore_V_B; TIGR02900 315750006986 MatE; Region: MatE; cl10513 315750006987 MatE; Region: MatE; cl10513 315750006988 Protein of unknown function (DUF421); Region: DUF421; cl00990 315750006989 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 315750006990 Preprotein translocase subunit; Region: YajC; cl00806 315750006991 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 315750006992 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 315750006993 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 315750006994 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 315750006995 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 315750006996 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 315750006997 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750006998 Walker A motif; other site 315750006999 ATP binding site [chemical binding]; other site 315750007000 Walker B motif; other site 315750007001 arginine finger; other site 315750007002 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 315750007003 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 315750007004 RuvA N terminal domain; Region: RuvA_N; pfam01330 315750007005 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 315750007006 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 315750007007 BofC C-terminal domain; Region: BofC_C; pfam08955 315750007008 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 315750007009 active site 315750007010 substrate binding site [chemical binding]; other site 315750007011 ATP binding site [chemical binding]; other site 315750007012 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 315750007013 ThiC-associated domain; Region: ThiC-associated; pfam13667 315750007014 ThiC family; Region: ThiC; cl08031 315750007015 LysE type translocator; Region: LysE; cl00565 315750007016 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 315750007017 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 315750007018 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 315750007019 Quinolinate synthetase A protein; Region: NadA; cl00420 315750007020 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 315750007021 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 315750007022 dimerization interface [polypeptide binding]; other site 315750007023 active site 315750007024 L-aspartate oxidase; Provisional; Region: PRK08071 315750007025 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750007026 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 315750007027 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 315750007028 Helix-turn-helix domains; Region: HTH; cl00088 315750007029 3H domain; Region: 3H; pfam02829 315750007030 prephenate dehydratase; Provisional; Region: PRK11898 315750007031 Prephenate dehydratase; Region: PDT; pfam00800 315750007032 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 315750007033 putative L-Phe binding site [chemical binding]; other site 315750007034 hypothetical protein; Provisional; Region: PRK04435 315750007035 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 315750007036 GTPase CgtA; Reviewed; Region: obgE; PRK12297 315750007037 GTP1/OBG; Region: GTP1_OBG; pfam01018 315750007038 Obg GTPase; Region: Obg; cd01898 315750007039 G1 box; other site 315750007040 GTP/Mg2+ binding site [chemical binding]; other site 315750007041 Switch I region; other site 315750007042 G2 box; other site 315750007043 G3 box; other site 315750007044 Switch II region; other site 315750007045 G4 box; other site 315750007046 G5 box; other site 315750007047 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 315750007048 sensory histidine kinase DcuS; Provisional; Region: PRK11086 315750007049 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 315750007050 Protein of unknown function (DUF464); Region: DUF464; cl01080 315750007051 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 315750007052 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 315750007053 active site 315750007054 putative substrate binding region [chemical binding]; other site 315750007055 Peptidase family M23; Region: Peptidase_M23; pfam01551 315750007056 septum site-determining protein MinD; Region: minD_bact; TIGR01968 315750007057 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 315750007058 Switch I; other site 315750007059 Switch II; other site 315750007060 septum formation inhibitor; Reviewed; Region: minC; PRK00513 315750007061 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 315750007062 rod shape-determining protein MreD; Region: MreD; cl01087 315750007063 rod shape-determining protein MreC; Provisional; Region: PRK13922 315750007064 rod shape-determining protein MreC; Region: MreC; pfam04085 315750007065 rod shape-determining protein MreB; Provisional; Region: PRK13927 315750007066 Cell division protein FtsA; Region: FtsA; cl11496 315750007067 hypothetical protein; Reviewed; Region: PRK00024 315750007068 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 315750007069 MPN+ (JAMM) motif; other site 315750007070 Zinc-binding site [ion binding]; other site 315750007071 Maf-like protein; Region: Maf; pfam02545 315750007072 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 315750007073 active site 315750007074 dimer interface [polypeptide binding]; other site 315750007075 Sporulation related domain; Region: SPOR; cl10051 315750007076 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 315750007077 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 315750007078 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 315750007079 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 315750007080 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 315750007081 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 315750007082 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 315750007083 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 315750007084 active site 315750007085 HIGH motif; other site 315750007086 nucleotide binding site [chemical binding]; other site 315750007087 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 315750007088 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 315750007089 active site 315750007090 KMSKS motif; other site 315750007091 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 315750007092 tRNA binding surface [nucleotide binding]; other site 315750007093 anticodon binding site; other site 315750007094 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 315750007095 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315750007096 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 315750007097 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 315750007098 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 315750007099 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315750007100 inhibitor-cofactor binding pocket; inhibition site 315750007101 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750007102 catalytic residue [active] 315750007103 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 315750007104 dimer interface [polypeptide binding]; other site 315750007105 active site 315750007106 Schiff base residues; other site 315750007107 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 315750007108 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 315750007109 active site 315750007110 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 315750007111 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 315750007112 domain interfaces; other site 315750007113 active site 315750007114 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 315750007115 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 315750007116 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 315750007117 tRNA; other site 315750007118 putative tRNA binding site [nucleotide binding]; other site 315750007119 putative NADP binding site [chemical binding]; other site 315750007120 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 315750007121 Predicted GTPase [General function prediction only]; Region: COG0218 315750007122 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 315750007123 G1 box; other site 315750007124 GTP/Mg2+ binding site [chemical binding]; other site 315750007125 Switch I region; other site 315750007126 G2 box; other site 315750007127 G3 box; other site 315750007128 Switch II region; other site 315750007129 G4 box; other site 315750007130 G5 box; other site 315750007131 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 315750007132 Found in ATP-dependent protease La (LON); Region: LON; smart00464 315750007133 Found in ATP-dependent protease La (LON); Region: LON; smart00464 315750007134 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750007135 Walker A motif; other site 315750007136 ATP binding site [chemical binding]; other site 315750007137 Walker B motif; other site 315750007138 arginine finger; other site 315750007139 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 315750007140 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 315750007141 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750007142 Walker A motif; other site 315750007143 ATP binding site [chemical binding]; other site 315750007144 Walker B motif; other site 315750007145 arginine finger; other site 315750007146 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 315750007147 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 315750007148 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 315750007149 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750007150 Walker A motif; other site 315750007151 ATP binding site [chemical binding]; other site 315750007152 Walker B motif; other site 315750007153 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 315750007154 trigger factor; Provisional; Region: tig; PRK01490 315750007155 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 315750007156 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 315750007157 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750007158 binding surface 315750007159 TPR motif; other site 315750007160 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 315750007161 substrate binding site [chemical binding]; other site 315750007162 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 315750007163 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 315750007164 substrate binding site [chemical binding]; other site 315750007165 ligand binding site [chemical binding]; other site 315750007166 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 315750007167 tartrate dehydrogenase; Provisional; Region: PRK08194 315750007168 2-isopropylmalate synthase; Validated; Region: PRK00915 315750007169 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 315750007170 active site 315750007171 catalytic residues [active] 315750007172 metal binding site [ion binding]; metal-binding site 315750007173 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 315750007174 ketol-acid reductoisomerase; Provisional; Region: PRK05479 315750007175 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750007176 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 315750007177 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 315750007178 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 315750007179 putative valine binding site [chemical binding]; other site 315750007180 dimer interface [polypeptide binding]; other site 315750007181 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 315750007182 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 315750007183 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 315750007184 PYR/PP interface [polypeptide binding]; other site 315750007185 dimer interface [polypeptide binding]; other site 315750007186 TPP binding site [chemical binding]; other site 315750007187 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 315750007188 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 315750007189 TPP-binding site [chemical binding]; other site 315750007190 dimer interface [polypeptide binding]; other site 315750007191 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 315750007192 homodimer interface [polypeptide binding]; other site 315750007193 substrate-cofactor binding pocket; other site 315750007194 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750007195 catalytic residue [active] 315750007196 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 315750007197 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 315750007198 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 315750007199 DltD N-terminal region; Region: DltD_N; pfam04915 315750007200 DltD central region; Region: DltD_M; pfam04918 315750007201 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 315750007202 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315750007203 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 315750007204 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 315750007205 AMP-binding enzyme; Region: AMP-binding; cl15778 315750007206 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 315750007207 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 315750007208 putative dimer interface [polypeptide binding]; other site 315750007209 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315750007210 ligand binding site [chemical binding]; other site 315750007211 Zn binding site [ion binding]; other site 315750007212 Autophagy protein Apg9; Region: APG9; pfam04109 315750007213 LXG domain of WXG superfamily; Region: LXG; pfam04740 315750007214 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 315750007215 short chain dehydrogenase; Provisional; Region: PRK06701 315750007216 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750007217 NAD(P) binding site [chemical binding]; other site 315750007218 active site 315750007219 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 315750007220 active site 315750007221 metal binding site [ion binding]; metal-binding site 315750007222 homotetramer interface [polypeptide binding]; other site 315750007223 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 315750007224 active site 315750007225 dimerization interface [polypeptide binding]; other site 315750007226 ribonuclease PH; Reviewed; Region: rph; PRK00173 315750007227 Ribonuclease PH; Region: RNase_PH_bact; cd11362 315750007228 hexamer interface [polypeptide binding]; other site 315750007229 active site 315750007230 Sporulation and spore germination; Region: Germane; cl11253 315750007231 Spore germination protein [General function prediction only]; Region: COG5401 315750007232 Sporulation and spore germination; Region: Germane; cl11253 315750007233 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 315750007234 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315750007235 Helix-turn-helix domains; Region: HTH; cl00088 315750007236 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 315750007237 DNA binding residues [nucleotide binding] 315750007238 dimerization interface [polypeptide binding]; other site 315750007239 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 315750007240 Citrate transporter; Region: CitMHS; pfam03600 315750007241 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315750007242 Helix-turn-helix domains; Region: HTH; cl00088 315750007243 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315750007244 dimerization interface [polypeptide binding]; other site 315750007245 PrpF protein; Region: PrpF; pfam04303 315750007246 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 315750007247 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 315750007248 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 315750007249 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 315750007250 active site 315750007251 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 315750007252 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 315750007253 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 315750007254 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 315750007255 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750007256 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 315750007257 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 315750007258 putative Iron-sulfur protein interface [polypeptide binding]; other site 315750007259 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 315750007260 proximal heme binding site [chemical binding]; other site 315750007261 distal heme binding site [chemical binding]; other site 315750007262 putative dimer interface [polypeptide binding]; other site 315750007263 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 315750007264 aspartate kinase; Reviewed; Region: PRK06635 315750007265 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 315750007266 putative nucleotide binding site [chemical binding]; other site 315750007267 putative catalytic residues [active] 315750007268 putative Mg ion binding site [ion binding]; other site 315750007269 putative aspartate binding site [chemical binding]; other site 315750007270 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 315750007271 putative allosteric regulatory site; other site 315750007272 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 315750007273 putative allosteric regulatory residue; other site 315750007274 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 315750007275 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 315750007276 GIY-YIG motif/motif A; other site 315750007277 active site 315750007278 catalytic site [active] 315750007279 putative DNA binding site [nucleotide binding]; other site 315750007280 metal binding site [ion binding]; metal-binding site 315750007281 UvrB/uvrC motif; Region: UVR; pfam02151 315750007282 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 315750007283 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 315750007284 catalytic residues [active] 315750007285 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 315750007286 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 315750007287 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 315750007288 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 315750007289 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 315750007290 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 315750007291 Ligand binding site [chemical binding]; other site 315750007292 Electron transfer flavoprotein domain; Region: ETF; pfam01012 315750007293 enoyl-CoA hydratase; Provisional; Region: PRK07658 315750007294 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 315750007295 substrate binding site [chemical binding]; other site 315750007296 oxyanion hole (OAH) forming residues; other site 315750007297 trimer interface [polypeptide binding]; other site 315750007298 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750007299 Helix-turn-helix domains; Region: HTH; cl00088 315750007300 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 315750007301 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 315750007302 AMP-binding enzyme; Region: AMP-binding; cl15778 315750007303 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315750007304 Predicted membrane protein [Function unknown]; Region: COG3766 315750007305 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 315750007306 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 315750007307 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 315750007308 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 315750007309 Walker A/P-loop; other site 315750007310 ATP binding site [chemical binding]; other site 315750007311 Q-loop/lid; other site 315750007312 ABC transporter signature motif; other site 315750007313 Walker B; other site 315750007314 D-loop; other site 315750007315 H-loop/switch region; other site 315750007316 Smr domain; Region: Smr; cl02619 315750007317 hypothetical protein; Provisional; Region: PRK08609 315750007318 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 315750007319 active site 315750007320 primer binding site [nucleotide binding]; other site 315750007321 NTP binding site [chemical binding]; other site 315750007322 metal binding triad [ion binding]; metal-binding site 315750007323 Colicin V production protein; Region: Colicin_V; cl00567 315750007324 Cell division protein ZapA; Region: ZapA; cl01146 315750007325 ribonuclease HIII; Provisional; Region: PRK00996 315750007326 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 315750007327 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 315750007328 RNA/DNA hybrid binding site [nucleotide binding]; other site 315750007329 active site 315750007330 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 315750007331 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 315750007332 putative tRNA-binding site [nucleotide binding]; other site 315750007333 B3/4 domain; Region: B3_4; cl11458 315750007334 tRNA synthetase B5 domain; Region: B5; cl08394 315750007335 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 315750007336 dimer interface [polypeptide binding]; other site 315750007337 motif 1; other site 315750007338 motif 3; other site 315750007339 motif 2; other site 315750007340 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 315750007341 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 315750007342 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 315750007343 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 315750007344 dimer interface [polypeptide binding]; other site 315750007345 motif 1; other site 315750007346 active site 315750007347 motif 2; other site 315750007348 motif 3; other site 315750007349 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 315750007350 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 315750007351 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 315750007352 Small, acid-soluble spore protein I; Region: SSPI; cl07940 315750007353 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 315750007354 Carbon starvation protein CstA; Region: CstA; pfam02554 315750007355 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 315750007356 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 315750007357 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 315750007358 oligomer interface [polypeptide binding]; other site 315750007359 active site 315750007360 metal binding site [ion binding]; metal-binding site 315750007361 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 315750007362 ribosomal protein L20; Region: rpl20; CHL00068 315750007363 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 315750007364 23S rRNA binding site [nucleotide binding]; other site 315750007365 L21 binding site [polypeptide binding]; other site 315750007366 L13 binding site [polypeptide binding]; other site 315750007367 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 315750007368 LrgB-like family; Region: LrgB; cl00596 315750007369 LrgA family; Region: LrgA; cl00608 315750007370 two-component response regulator; Provisional; Region: PRK14084 315750007371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750007372 active site 315750007373 phosphorylation site [posttranslational modification] 315750007374 intermolecular recognition site; other site 315750007375 dimerization interface [polypeptide binding]; other site 315750007376 LytTr DNA-binding domain; Region: LytTR; cl04498 315750007377 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 315750007378 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 315750007379 GAF domain; Region: GAF; cl15785 315750007380 Histidine kinase; Region: His_kinase; pfam06580 315750007381 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750007382 ATP binding site [chemical binding]; other site 315750007383 Mg2+ binding site [ion binding]; other site 315750007384 G-X-G motif; other site 315750007385 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 315750007386 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750007387 motif II; other site 315750007388 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315750007389 PAS domain; Region: PAS_9; pfam13426 315750007390 putative active site [active] 315750007391 heme pocket [chemical binding]; other site 315750007392 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750007393 dimer interface [polypeptide binding]; other site 315750007394 putative CheW interface [polypeptide binding]; other site 315750007395 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 315750007396 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 315750007397 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 315750007398 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 315750007399 active site 315750007400 dimer interface [polypeptide binding]; other site 315750007401 motif 1; other site 315750007402 motif 2; other site 315750007403 motif 3; other site 315750007404 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 315750007405 anticodon binding site; other site 315750007406 YtxC-like family; Region: YtxC; cl08500 315750007407 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 315750007408 primosomal protein DnaI; Reviewed; Region: PRK08939 315750007409 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 315750007410 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750007411 Walker A motif; other site 315750007412 ATP binding site [chemical binding]; other site 315750007413 Walker B motif; other site 315750007414 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 315750007415 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 315750007416 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 315750007417 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 315750007418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750007419 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 315750007420 dephospho-CoA kinase; Region: TIGR00152 315750007421 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 315750007422 CoA-binding site [chemical binding]; other site 315750007423 ATP-binding [chemical binding]; other site 315750007424 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 315750007425 Domain of unknown function DUF; Region: DUF204; pfam02659 315750007426 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 315750007427 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 315750007428 DNA binding site [nucleotide binding] 315750007429 catalytic residue [active] 315750007430 H2TH interface [polypeptide binding]; other site 315750007431 putative catalytic residues [active] 315750007432 turnover-facilitating residue; other site 315750007433 intercalation triad [nucleotide binding]; other site 315750007434 8OG recognition residue [nucleotide binding]; other site 315750007435 putative reading head residues; other site 315750007436 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 315750007437 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 315750007438 DNA polymerase I; Provisional; Region: PRK05755 315750007439 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 315750007440 active site 315750007441 metal binding site 1 [ion binding]; metal-binding site 315750007442 putative 5' ssDNA interaction site; other site 315750007443 metal binding site 3; metal-binding site 315750007444 metal binding site 2 [ion binding]; metal-binding site 315750007445 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 315750007446 putative DNA binding site [nucleotide binding]; other site 315750007447 putative metal binding site [ion binding]; other site 315750007448 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 315750007449 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 315750007450 active site 315750007451 DNA binding site [nucleotide binding] 315750007452 catalytic site [active] 315750007453 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 315750007454 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 315750007455 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315750007456 dimer interface [polypeptide binding]; other site 315750007457 phosphorylation site [posttranslational modification] 315750007458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750007459 ATP binding site [chemical binding]; other site 315750007460 Mg2+ binding site [ion binding]; other site 315750007461 G-X-G motif; other site 315750007462 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315750007463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750007464 active site 315750007465 phosphorylation site [posttranslational modification] 315750007466 intermolecular recognition site; other site 315750007467 dimerization interface [polypeptide binding]; other site 315750007468 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315750007469 DNA binding site [nucleotide binding] 315750007470 malate dehydrogenase; Reviewed; Region: PRK06223 315750007471 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 315750007472 NAD(P) binding site [chemical binding]; other site 315750007473 dimer interface [polypeptide binding]; other site 315750007474 tetramer (dimer of dimers) interface [polypeptide binding]; other site 315750007475 substrate binding site [chemical binding]; other site 315750007476 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 315750007477 isocitrate dehydrogenase; Validated; Region: PRK07362 315750007478 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 315750007479 dimer interface [polypeptide binding]; other site 315750007480 Citrate synthase; Region: Citrate_synt; pfam00285 315750007481 active site 315750007482 citrylCoA binding site [chemical binding]; other site 315750007483 oxalacetate/citrate binding site [chemical binding]; other site 315750007484 coenzyme A binding site [chemical binding]; other site 315750007485 catalytic triad [active] 315750007486 Protein of unknown function (DUF441); Region: DUF441; cl01041 315750007487 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 315750007488 Domain of unknown function DUF20; Region: UPF0118; pfam01594 315750007489 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 315750007490 pyruvate kinase; Provisional; Region: PRK06354 315750007491 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 315750007492 domain interfaces; other site 315750007493 active site 315750007494 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 315750007495 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 315750007496 active site 315750007497 ADP/pyrophosphate binding site [chemical binding]; other site 315750007498 dimerization interface [polypeptide binding]; other site 315750007499 allosteric effector site; other site 315750007500 fructose-1,6-bisphosphate binding site; other site 315750007501 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 315750007502 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 315750007503 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 315750007504 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 315750007505 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 315750007506 Malic enzyme, N-terminal domain; Region: malic; pfam00390 315750007507 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 315750007508 putative NAD(P) binding site [chemical binding]; other site 315750007509 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 315750007510 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 315750007511 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 315750007512 generic binding surface I; other site 315750007513 generic binding surface II; other site 315750007514 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 315750007515 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 315750007516 DHH family; Region: DHH; pfam01368 315750007517 DHHA1 domain; Region: DHHA1; pfam02272 315750007518 YtpI-like protein; Region: YtpI; pfam14007 315750007519 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 315750007520 Helix-turn-helix domains; Region: HTH; cl00088 315750007521 DNA-binding site [nucleotide binding]; DNA binding site 315750007522 DRTGG domain; Region: DRTGG; cl12147 315750007523 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 315750007524 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 315750007525 active site 2 [active] 315750007526 active site 1 [active] 315750007527 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315750007528 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 315750007529 classical (c) SDRs; Region: SDR_c; cd05233 315750007530 NAD(P) binding site [chemical binding]; other site 315750007531 active site 315750007532 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315750007533 Phosphotransferase enzyme family; Region: APH; pfam01636 315750007534 active site 315750007535 ATP binding site [chemical binding]; other site 315750007536 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315750007537 active site 315750007538 ATP binding site [chemical binding]; other site 315750007539 argininosuccinate lyase; Provisional; Region: PRK00855 315750007540 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 315750007541 active sites [active] 315750007542 tetramer interface [polypeptide binding]; other site 315750007543 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 315750007544 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 315750007545 ANP binding site [chemical binding]; other site 315750007546 Substrate Binding Site II [chemical binding]; other site 315750007547 Substrate Binding Site I [chemical binding]; other site 315750007548 acetate kinase; Region: ackA; TIGR00016 315750007549 Acetokinase family; Region: Acetate_kinase; cl01029 315750007550 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 315750007551 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 315750007552 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 315750007553 dimer interface [polypeptide binding]; other site 315750007554 catalytic triad [active] 315750007555 peroxidatic and resolving cysteines [active] 315750007556 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 315750007557 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 315750007558 RDD family; Region: RDD; cl00746 315750007559 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 315750007560 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 315750007561 tandem repeat interface [polypeptide binding]; other site 315750007562 oligomer interface [polypeptide binding]; other site 315750007563 active site residues [active] 315750007564 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 315750007565 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 315750007566 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 315750007567 ATP binding site [chemical binding]; other site 315750007568 Mg++ binding site [ion binding]; other site 315750007569 motif III; other site 315750007570 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315750007571 nucleotide binding region [chemical binding]; other site 315750007572 ATP-binding site [chemical binding]; other site 315750007573 DbpA RNA binding domain; Region: DbpA; pfam03880 315750007574 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 315750007575 Fatty acid desaturase; Region: FA_desaturase; pfam00487 315750007576 putative di-iron ligands [ion binding]; other site 315750007577 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 315750007578 Histidine kinase; Region: HisKA_3; pfam07730 315750007579 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 315750007580 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 315750007581 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750007582 active site 315750007583 phosphorylation site [posttranslational modification] 315750007584 intermolecular recognition site; other site 315750007585 dimerization interface [polypeptide binding]; other site 315750007586 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 315750007587 DNA binding residues [nucleotide binding] 315750007588 dimerization interface [polypeptide binding]; other site 315750007589 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 315750007590 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 315750007591 putative ligand binding residues [chemical binding]; other site 315750007592 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315750007593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750007594 active site 315750007595 phosphorylation site [posttranslational modification] 315750007596 intermolecular recognition site; other site 315750007597 dimerization interface [polypeptide binding]; other site 315750007598 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315750007599 DNA binding site [nucleotide binding] 315750007600 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315750007601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750007602 ATP binding site [chemical binding]; other site 315750007603 Mg2+ binding site [ion binding]; other site 315750007604 G-X-G motif; other site 315750007605 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315750007606 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 315750007607 Walker A/P-loop; other site 315750007608 ATP binding site [chemical binding]; other site 315750007609 Q-loop/lid; other site 315750007610 ABC transporter signature motif; other site 315750007611 Walker B; other site 315750007612 D-loop; other site 315750007613 H-loop/switch region; other site 315750007614 FtsX-like permease family; Region: FtsX; cl15850 315750007615 hypothetical protein; Provisional; Region: PRK08204 315750007616 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 315750007617 active site 315750007618 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 315750007619 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315750007620 Helix-turn-helix domains; Region: HTH; cl00088 315750007621 LysE type translocator; Region: LysE; cl00565 315750007622 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 315750007623 AMP-binding enzyme; Region: AMP-binding; cl15778 315750007624 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315750007625 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 315750007626 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 315750007627 THUMP domain; Region: THUMP; cl12076 315750007628 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 315750007629 Ligand Binding Site [chemical binding]; other site 315750007630 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 315750007631 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 315750007632 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 315750007633 histidinol-phosphatase; Reviewed; Region: PRK08123 315750007634 PHP-associated; Region: PHP_C; pfam13263 315750007635 Helix-turn-helix domains; Region: HTH; cl00088 315750007636 GAF domain; Region: GAF; cl15785 315750007637 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 315750007638 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 315750007639 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315750007640 RNA binding surface [nucleotide binding]; other site 315750007641 Isochorismatase family; Region: Isochorismatase; pfam00857 315750007642 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 315750007643 catalytic triad [active] 315750007644 conserved cis-peptide bond; other site 315750007645 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315750007646 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 315750007647 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 315750007648 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 315750007649 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 315750007650 active site 315750007651 HIGH motif; other site 315750007652 dimer interface [polypeptide binding]; other site 315750007653 KMSKS motif; other site 315750007654 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315750007655 RNA binding surface [nucleotide binding]; other site 315750007656 acetyl-CoA synthetase; Provisional; Region: PRK04319 315750007657 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 315750007658 AMP-binding enzyme; Region: AMP-binding; cl15778 315750007659 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315750007660 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315750007661 FOG: CBS domain [General function prediction only]; Region: COG0517 315750007662 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 315750007663 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 315750007664 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 315750007665 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 315750007666 catabolite control protein A; Region: ccpA; TIGR01481 315750007667 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315750007668 DNA binding site [nucleotide binding] 315750007669 domain linker motif; other site 315750007670 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 315750007671 dimerization interface [polypeptide binding]; other site 315750007672 effector binding site; other site 315750007673 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 315750007674 Chorismate mutase type II; Region: CM_2; cl00693 315750007675 NeuB family; Region: NeuB; cl00496 315750007676 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 315750007677 YtxH-like protein; Region: YtxH; cl02079 315750007678 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 315750007679 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 315750007680 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 315750007681 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 315750007682 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 315750007683 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 315750007684 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750007685 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 315750007686 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 315750007687 putative tRNA-binding site [nucleotide binding]; other site 315750007688 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 315750007689 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 315750007690 catalytic residues [active] 315750007691 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 315750007692 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 315750007693 Protein of unknown function (DUF2872); Region: DUF2872; cl11924 315750007694 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 315750007695 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 315750007696 oligomer interface [polypeptide binding]; other site 315750007697 active site 315750007698 metal binding site [ion binding]; metal-binding site 315750007699 Predicted small secreted protein [Function unknown]; Region: COG5584 315750007700 malate dehydrogenase; Provisional; Region: PRK13529 315750007701 Malic enzyme, N-terminal domain; Region: malic; pfam00390 315750007702 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 315750007703 NAD(P) binding site [chemical binding]; other site 315750007704 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 315750007705 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315750007706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750007707 S-adenosylmethionine binding site [chemical binding]; other site 315750007708 YtzH-like protein; Region: YtzH; pfam14165 315750007709 Phosphotransferase enzyme family; Region: APH; pfam01636 315750007710 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 315750007711 active site 315750007712 substrate binding site [chemical binding]; other site 315750007713 ATP binding site [chemical binding]; other site 315750007714 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 315750007715 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 315750007716 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 315750007717 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 315750007718 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 315750007719 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 315750007720 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 315750007721 dimer interface [polypeptide binding]; other site 315750007722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750007723 catalytic residue [active] 315750007724 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 315750007725 conserved cys residue [active] 315750007726 dipeptidase PepV; Reviewed; Region: PRK07318 315750007727 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 315750007728 active site 315750007729 metal binding site [ion binding]; metal-binding site 315750007730 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 315750007731 Helix-turn-helix domains; Region: HTH; cl00088 315750007732 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 315750007733 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315750007734 RNA binding surface [nucleotide binding]; other site 315750007735 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 315750007736 active site 315750007737 uracil binding [chemical binding]; other site 315750007738 stage V sporulation protein B; Region: spore_V_B; TIGR02900 315750007739 MatE; Region: MatE; cl10513 315750007740 HI0933-like protein; Region: HI0933_like; pfam03486 315750007741 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750007742 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750007743 BCCT family transporter; Region: BCCT; cl00569 315750007744 Uncharacterized protein family (UPF0167); Region: UPF0167; cl01252 315750007745 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 315750007746 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 315750007747 active site residue [active] 315750007748 Protein of unknown function, DUF624; Region: DUF624; cl02369 315750007749 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750007750 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 315750007751 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 315750007752 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 315750007753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 315750007754 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 315750007755 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315750007756 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315750007757 Helix-turn-helix domains; Region: HTH; cl00088 315750007758 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 315750007759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750007760 putative substrate translocation pore; other site 315750007761 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 315750007762 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 315750007763 active site 315750007764 catalytic tetrad [active] 315750007765 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 315750007766 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 315750007767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750007768 dimer interface [polypeptide binding]; other site 315750007769 conserved gate region; other site 315750007770 putative PBP binding loops; other site 315750007771 ABC-ATPase subunit interface; other site 315750007772 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750007773 NAD(P) binding site [chemical binding]; other site 315750007774 active site 315750007775 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315750007776 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 315750007777 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 315750007778 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 315750007779 HIGH motif; other site 315750007780 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 315750007781 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 315750007782 active site 315750007783 KMSKS motif; other site 315750007784 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 315750007785 tRNA binding surface [nucleotide binding]; other site 315750007786 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 315750007787 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315750007788 PAS domain; Region: PAS_9; pfam13426 315750007789 putative active site [active] 315750007790 heme pocket [chemical binding]; other site 315750007791 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 315750007792 Protein of unknown function (DUF981); Region: DUF981; cl01337 315750007793 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 315750007794 FtsX-like permease family; Region: FtsX; cl15850 315750007795 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315750007796 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 315750007797 Walker A/P-loop; other site 315750007798 ATP binding site [chemical binding]; other site 315750007799 Q-loop/lid; other site 315750007800 ABC transporter signature motif; other site 315750007801 Walker B; other site 315750007802 D-loop; other site 315750007803 H-loop/switch region; other site 315750007804 ABC-2 type transporter; Region: ABC2_membrane; cl11417 315750007805 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315750007806 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 315750007807 Walker A/P-loop; other site 315750007808 ATP binding site [chemical binding]; other site 315750007809 Q-loop/lid; other site 315750007810 ABC transporter signature motif; other site 315750007811 Walker B; other site 315750007812 D-loop; other site 315750007813 H-loop/switch region; other site 315750007814 Predicted transcriptional regulators [Transcription]; Region: COG1725 315750007815 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315750007816 DNA-binding site [nucleotide binding]; DNA binding site 315750007817 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 315750007818 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 315750007819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750007820 S-adenosylmethionine binding site [chemical binding]; other site 315750007821 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 315750007822 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 315750007823 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315750007824 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315750007825 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 315750007826 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 315750007827 trimer interface [polypeptide binding]; other site 315750007828 putative metal binding site [ion binding]; other site 315750007829 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 315750007830 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 315750007831 active site 315750007832 dimer interface [polypeptide binding]; other site 315750007833 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 315750007834 Ligand Binding Site [chemical binding]; other site 315750007835 Molecular Tunnel; other site 315750007836 S-adenosylmethionine synthetase; Validated; Region: PRK05250 315750007837 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 315750007838 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 315750007839 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 315750007840 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 315750007841 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 315750007842 active site 315750007843 substrate-binding site [chemical binding]; other site 315750007844 metal-binding site [ion binding] 315750007845 ATP binding site [chemical binding]; other site 315750007846 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 315750007847 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315750007848 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315750007849 phytoene desaturase; Region: crtI_fam; TIGR02734 315750007850 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750007851 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 315750007852 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 315750007853 active site 315750007854 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 315750007855 putative acyl-acceptor binding pocket; other site 315750007856 Protein of unknown function (DUF422); Region: DUF422; cl00991 315750007857 NMT1-like family; Region: NMT1_2; cl15260 315750007858 NMT1/THI5 like; Region: NMT1; pfam09084 315750007859 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 315750007860 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 315750007861 Walker A/P-loop; other site 315750007862 ATP binding site [chemical binding]; other site 315750007863 Q-loop/lid; other site 315750007864 ABC transporter signature motif; other site 315750007865 Walker B; other site 315750007866 D-loop; other site 315750007867 H-loop/switch region; other site 315750007868 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 315750007869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750007870 dimer interface [polypeptide binding]; other site 315750007871 conserved gate region; other site 315750007872 putative PBP binding loops; other site 315750007873 ABC-ATPase subunit interface; other site 315750007874 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 315750007875 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 315750007876 nudix motif; other site 315750007877 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 315750007878 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 315750007879 putative metal binding site [ion binding]; other site 315750007880 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 315750007881 Holin family; Region: Phage_holin_4; cl01989 315750007882 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 315750007883 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 315750007884 dimerization interface [polypeptide binding]; other site 315750007885 DPS ferroxidase diiron center [ion binding]; other site 315750007886 ion pore; other site 315750007887 FixH; Region: FixH; cl01254 315750007888 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 315750007889 Haemolytic domain; Region: Haemolytic; cl00506 315750007890 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 315750007891 active site clefts [active] 315750007892 zinc binding site [ion binding]; other site 315750007893 dimer interface [polypeptide binding]; other site 315750007894 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 315750007895 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 315750007896 metal binding site [ion binding]; metal-binding site 315750007897 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 315750007898 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 315750007899 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 315750007900 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 315750007901 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 315750007902 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 315750007903 active site 315750007904 octamer interface [polypeptide binding]; other site 315750007905 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 315750007906 AMP-binding enzyme; Region: AMP-binding; cl15778 315750007907 AMP-binding enzyme; Region: AMP-binding; cl15778 315750007908 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 315750007909 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 315750007910 substrate binding site [chemical binding]; other site 315750007911 oxyanion hole (OAH) forming residues; other site 315750007912 trimer interface [polypeptide binding]; other site 315750007913 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315750007914 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 315750007915 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 315750007916 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 315750007917 dimer interface [polypeptide binding]; other site 315750007918 tetramer interface [polypeptide binding]; other site 315750007919 PYR/PP interface [polypeptide binding]; other site 315750007920 TPP binding site [chemical binding]; other site 315750007921 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 315750007922 TPP-binding site; other site 315750007923 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 315750007924 chorismate binding enzyme; Region: Chorismate_bind; cl10555 315750007925 UbiA prenyltransferase family; Region: UbiA; cl00337 315750007926 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 315750007927 TspO/MBR family; Region: TspO_MBR; cl01379 315750007928 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 315750007929 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 315750007930 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315750007931 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 315750007932 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 315750007933 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 315750007934 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 315750007935 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 315750007936 DinB superfamily; Region: DinB_2; pfam12867 315750007937 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 315750007938 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 315750007939 active site 315750007940 NAD binding site [chemical binding]; other site 315750007941 metal binding site [ion binding]; metal-binding site 315750007942 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 315750007943 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 315750007944 tetramerization interface [polypeptide binding]; other site 315750007945 NAD(P) binding site [chemical binding]; other site 315750007946 catalytic residues [active] 315750007947 Predicted transcriptional regulators [Transcription]; Region: COG1510 315750007948 Helix-turn-helix domains; Region: HTH; cl00088 315750007949 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 315750007950 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 315750007951 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 315750007952 OpgC protein; Region: OpgC_C; cl00792 315750007953 Acyltransferase family; Region: Acyl_transf_3; pfam01757 315750007954 Phage lysis protein, holin; Region: Phage_holin; cl04675 315750007955 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 315750007956 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 315750007957 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 315750007958 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 315750007959 XkdW protein; Region: XkdW; pfam09636 315750007960 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 315750007961 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 315750007962 Baseplate J-like protein; Region: Baseplate_J; cl01294 315750007963 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 315750007964 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 315750007965 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 315750007966 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 315750007967 Phage-related protein [Function unknown]; Region: COG5412 315750007968 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 315750007969 N-acetyl-D-glucosamine binding site [chemical binding]; other site 315750007970 catalytic residue [active] 315750007971 Phage XkdN-like protein; Region: XkdN; pfam08890 315750007972 similar to hypothetical protein 315750007973 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 315750007974 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 315750007975 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 315750007976 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 315750007977 Phage capsid family; Region: Phage_capsid; pfam05065 315750007978 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 315750007979 Phage-related protein [Function unknown]; Region: COG4695; cl01923 315750007980 phage portal protein, PBSX family; Region: portal_PBSX; TIGR01540 315750007981 Phage terminase large subunit; Region: Terminase_3; cl12054 315750007982 Terminase-like family; Region: Terminase_6; pfam03237 315750007983 Uncharacterized conserved protein [Function unknown]; Region: COG5484 315750007984 Helix-turn-helix domains; Region: HTH; cl00088 315750007985 positive control sigma-like factor; Validated; Region: PRK06930 315750007986 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315750007987 DNA binding residues [nucleotide binding] 315750007988 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315750007989 non-specific DNA binding site [nucleotide binding]; other site 315750007990 salt bridge; other site 315750007991 sequence-specific DNA binding site [nucleotide binding]; other site 315750007992 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315750007993 non-specific DNA binding site [nucleotide binding]; other site 315750007994 salt bridge; other site 315750007995 sequence-specific DNA binding site [nucleotide binding]; other site 315750007996 biotin synthase; Validated; Region: PRK06256 315750007997 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315750007998 FeS/SAM binding site; other site 315750007999 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 315750008000 Bacitracin resistance protein BacA; Region: BacA; cl00858 315750008001 Domain of unknown function DUF20; Region: UPF0118; pfam01594 315750008002 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 315750008003 Predicted membrane protein [Function unknown]; Region: COG4270 315750008004 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 315750008005 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750008006 intracellular protease, PfpI family; Region: PfpI; TIGR01382 315750008007 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 315750008008 proposed catalytic triad [active] 315750008009 conserved cys residue [active] 315750008010 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 315750008011 Cache domain; Region: Cache_1; pfam02743 315750008012 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315750008013 dimerization interface [polypeptide binding]; other site 315750008014 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315750008015 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750008016 dimer interface [polypeptide binding]; other site 315750008017 putative CheW interface [polypeptide binding]; other site 315750008018 Cache domain; Region: Cache_1; pfam02743 315750008019 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315750008020 dimerization interface [polypeptide binding]; other site 315750008021 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750008022 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315750008023 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750008024 dimer interface [polypeptide binding]; other site 315750008025 putative CheW interface [polypeptide binding]; other site 315750008026 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 315750008027 Cache domain; Region: Cache_1; pfam02743 315750008028 proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785 315750008029 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315750008030 dimerization interface [polypeptide binding]; other site 315750008031 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315750008032 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750008033 dimer interface [polypeptide binding]; other site 315750008034 putative CheW interface [polypeptide binding]; other site 315750008035 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 315750008036 Cache domain; Region: Cache_1; pfam02743 315750008037 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315750008038 dimerization interface [polypeptide binding]; other site 315750008039 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315750008040 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750008041 dimer interface [polypeptide binding]; other site 315750008042 putative CheW interface [polypeptide binding]; other site 315750008043 transglutaminase; Provisional; Region: tgl; PRK03187 315750008044 Nitronate monooxygenase; Region: NMO; pfam03060 315750008045 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 315750008046 FMN binding site [chemical binding]; other site 315750008047 substrate binding site [chemical binding]; other site 315750008048 putative catalytic residue [active] 315750008049 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 315750008050 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 315750008051 Domain of unknown function DUF21; Region: DUF21; pfam01595 315750008052 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 315750008053 Transporter associated domain; Region: CorC_HlyC; cl08393 315750008054 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 315750008055 Ion channel; Region: Ion_trans_2; cl11596 315750008056 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750008057 YugN-like family; Region: YugN; pfam08868 315750008058 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 315750008059 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 315750008060 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 315750008061 active site 315750008062 dimer interface [polypeptide binding]; other site 315750008063 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 315750008064 dimer interface [polypeptide binding]; other site 315750008065 active site 315750008066 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 315750008067 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 315750008068 dimer interface [polypeptide binding]; other site 315750008069 active site 315750008070 metal binding site [ion binding]; metal-binding site 315750008071 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 315750008072 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 315750008073 dimer interface [polypeptide binding]; other site 315750008074 active site 315750008075 metal binding site [ion binding]; metal-binding site 315750008076 Domain of unknown function (DUF378); Region: DUF378; cl00943 315750008077 general stress protein 13; Validated; Region: PRK08059 315750008078 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 315750008079 RNA binding site [nucleotide binding]; other site 315750008080 hypothetical protein; Validated; Region: PRK07682 315750008081 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315750008082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750008083 homodimer interface [polypeptide binding]; other site 315750008084 catalytic residue [active] 315750008085 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 315750008086 AsnC family; Region: AsnC_trans_reg; pfam01037 315750008087 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315750008088 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315750008089 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 315750008090 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 315750008091 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315750008092 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750008093 homodimer interface [polypeptide binding]; other site 315750008094 catalytic residue [active] 315750008095 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 315750008096 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315750008097 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315750008098 dimer interface [polypeptide binding]; other site 315750008099 phosphorylation site [posttranslational modification] 315750008100 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750008101 ATP binding site [chemical binding]; other site 315750008102 Mg2+ binding site [ion binding]; other site 315750008103 G-X-G motif; other site 315750008104 Kinase associated protein B; Region: KapB; pfam08810 315750008105 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 315750008106 active site 315750008107 catalytic site [active] 315750008108 substrate binding site [chemical binding]; other site 315750008109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750008110 drug efflux system protein MdtG; Provisional; Region: PRK09874 315750008111 putative substrate translocation pore; other site 315750008112 Transglycosylase; Region: Transgly; cl07896 315750008113 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 315750008114 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315750008115 Protein of unknown function, DUF393; Region: DUF393; cl01136 315750008116 sensory histidine kinase DcuS; Provisional; Region: PRK11086 315750008117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750008118 ATP binding site [chemical binding]; other site 315750008119 Mg2+ binding site [ion binding]; other site 315750008120 G-X-G motif; other site 315750008121 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 315750008122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750008123 active site 315750008124 phosphorylation site [posttranslational modification] 315750008125 intermolecular recognition site; other site 315750008126 dimerization interface [polypeptide binding]; other site 315750008127 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 315750008128 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 315750008129 ligand binding site [chemical binding]; other site 315750008130 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 315750008131 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 315750008132 Walker A/P-loop; other site 315750008133 ATP binding site [chemical binding]; other site 315750008134 Q-loop/lid; other site 315750008135 ABC transporter signature motif; other site 315750008136 Walker B; other site 315750008137 D-loop; other site 315750008138 H-loop/switch region; other site 315750008139 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 315750008140 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 315750008141 TM-ABC transporter signature motif; other site 315750008142 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 315750008143 TM-ABC transporter signature motif; other site 315750008144 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 315750008145 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 315750008146 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 315750008147 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 315750008148 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 315750008149 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 315750008150 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 315750008151 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 315750008152 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 315750008153 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 315750008154 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 315750008155 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 315750008156 CoenzymeA binding site [chemical binding]; other site 315750008157 subunit interaction site [polypeptide binding]; other site 315750008158 PHB binding site; other site 315750008159 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 315750008160 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750008161 active site 315750008162 phosphorylation site [posttranslational modification] 315750008163 intermolecular recognition site; other site 315750008164 dimerization interface [polypeptide binding]; other site 315750008165 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 315750008166 DNA binding residues [nucleotide binding] 315750008167 dimerization interface [polypeptide binding]; other site 315750008168 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 315750008169 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 315750008170 Histidine kinase; Region: HisKA_3; pfam07730 315750008171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750008172 ATP binding site [chemical binding]; other site 315750008173 Mg2+ binding site [ion binding]; other site 315750008174 G-X-G motif; other site 315750008175 Bacillus competence pheromone ComX; Region: ComX; pfam05952 315750008176 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 315750008177 aspartate-rich region 2; other site 315750008178 DegQ (SacQ) family; Region: DegQ; pfam08181 315750008179 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 315750008180 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 315750008181 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 315750008182 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 315750008183 active site 315750008184 Isochorismatase family; Region: Isochorismatase; pfam00857 315750008185 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 315750008186 catalytic triad [active] 315750008187 conserved cis-peptide bond; other site 315750008188 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 315750008189 YueH-like protein; Region: YueH; pfam14166 315750008190 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 315750008191 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 315750008192 Domain of unknown function DUF20; Region: UPF0118; pfam01594 315750008193 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 315750008194 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 315750008195 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315750008196 Lecithin:cholesterol acyltransferase; Region: LACT; pfam02450 315750008197 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 315750008198 short chain dehydrogenase; Provisional; Region: PRK06924 315750008199 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750008200 NAD(P) binding site [chemical binding]; other site 315750008201 active site 315750008202 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 315750008203 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 315750008204 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 315750008205 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 315750008206 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 315750008207 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 315750008208 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 315750008209 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 315750008210 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750008211 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750008212 Domain of unknown function DUF87; Region: DUF87; pfam01935 315750008213 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 315750008214 Ubiquitin-like proteins; Region: UBQ; cl00155 315750008215 Proteins of 100 residues with WXG; Region: WXG100; cl02005 315750008216 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 315750008217 CodY GAF-like domain; Region: CodY; pfam06018 315750008218 Helix-turn-helix domains; Region: HTH; cl00088 315750008219 alanine dehydrogenase; Region: alaDH; TIGR00518 315750008220 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 315750008221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750008222 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 315750008223 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 315750008224 SpoOM protein; Region: Spo0M; pfam07070 315750008225 Predicted permease [General function prediction only]; Region: COG2056 315750008226 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 315750008227 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 315750008228 multifunctional aminopeptidase A; Provisional; Region: PRK00913 315750008229 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 315750008230 interface (dimer of trimers) [polypeptide binding]; other site 315750008231 Substrate-binding/catalytic site; other site 315750008232 Zn-binding sites [ion binding]; other site 315750008233 Divergent PAP2 family; Region: DUF212; cl00855 315750008234 3D domain; Region: 3D; cl01439 315750008235 Putative membrane protein; Region: YuiB; pfam14068 315750008236 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 315750008237 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 315750008238 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315750008239 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 315750008240 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315750008241 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 315750008242 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 315750008243 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 315750008244 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 315750008245 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 315750008246 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 315750008247 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315750008248 WYL domain; Region: WYL; cl14852 315750008249 Protein of unknown function (DUF1462); Region: DUF1462; cl11552 315750008250 NifU-like domain; Region: NifU; cl00484 315750008251 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 315750008252 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315750008253 homoserine kinase; Provisional; Region: PRK01212 315750008254 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 315750008255 threonine synthase; Reviewed; Region: PRK06721 315750008256 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 315750008257 homodimer interface [polypeptide binding]; other site 315750008258 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750008259 catalytic residue [active] 315750008260 homoserine dehydrogenase; Provisional; Region: PRK06349 315750008261 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750008262 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 315750008263 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 315750008264 glyoxylate reductase; Reviewed; Region: PRK13243 315750008265 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750008266 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315750008267 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 315750008268 tetramer interfaces [polypeptide binding]; other site 315750008269 binuclear metal-binding site [ion binding]; other site 315750008270 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 315750008271 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750008272 active site 315750008273 motif I; other site 315750008274 motif II; other site 315750008275 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750008276 Protein of unknown function DUF86; Region: DUF86; cl01031 315750008277 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 315750008278 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 315750008279 lipoyl synthase; Provisional; Region: PRK05481 315750008280 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315750008281 FeS/SAM binding site; other site 315750008282 Peptidase family M23; Region: Peptidase_M23; pfam01551 315750008283 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 315750008284 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 315750008285 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 315750008286 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 315750008287 active site 315750008288 metal binding site [ion binding]; metal-binding site 315750008289 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 315750008290 Protein of unknown function DUF72; Region: DUF72; cl00777 315750008291 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 315750008292 Helix-turn-helix domains; Region: HTH; cl00088 315750008293 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 315750008294 Cupin domain; Region: Cupin_2; cl09118 315750008295 Cupin domain; Region: Cupin_2; cl09118 315750008296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750008297 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315750008298 putative substrate translocation pore; other site 315750008299 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 315750008300 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 315750008301 homodimer interface [polypeptide binding]; other site 315750008302 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750008303 catalytic residue [active] 315750008304 Endonuclease I; Region: Endonuclease_1; cl01003 315750008305 Uncharacterized Fe-S protein [General function prediction only]; Region: FhuF; COG4114 315750008306 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 315750008307 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 315750008308 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 315750008309 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315750008310 ABC-ATPase subunit interface; other site 315750008311 dimer interface [polypeptide binding]; other site 315750008312 putative PBP binding regions; other site 315750008313 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 315750008314 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315750008315 ABC-ATPase subunit interface; other site 315750008316 dimer interface [polypeptide binding]; other site 315750008317 putative PBP binding regions; other site 315750008318 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 315750008319 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 315750008320 siderophore binding site; other site 315750008321 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 315750008322 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315750008323 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315750008324 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 315750008325 Phosphate-starvation-inducible E; Region: PsiE; cl01264 315750008326 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315750008327 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 315750008328 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315750008329 dimer interface [polypeptide binding]; other site 315750008330 phosphorylation site [posttranslational modification] 315750008331 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315750008332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750008333 active site 315750008334 phosphorylation site [posttranslational modification] 315750008335 intermolecular recognition site; other site 315750008336 dimerization interface [polypeptide binding]; other site 315750008337 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315750008338 DNA binding site [nucleotide binding] 315750008339 Predicted membrane protein [Function unknown]; Region: COG2311 315750008340 Protein of unknown function (DUF418); Region: DUF418; cl12135 315750008341 Protein of unknown function (DUF418); Region: DUF418; cl12135 315750008342 Predicted transcriptional regulator [Transcription]; Region: COG2378 315750008343 Helix-turn-helix domains; Region: HTH; cl00088 315750008344 WYL domain; Region: WYL; cl14852 315750008345 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 315750008346 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 315750008347 FeS assembly protein SufB; Region: sufB; TIGR01980 315750008348 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 315750008349 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 315750008350 trimerization site [polypeptide binding]; other site 315750008351 active site 315750008352 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 315750008353 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 315750008354 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 315750008355 catalytic residue [active] 315750008356 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 315750008357 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 315750008358 FeS assembly ATPase SufC; Region: sufC; TIGR01978 315750008359 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 315750008360 Walker A/P-loop; other site 315750008361 ATP binding site [chemical binding]; other site 315750008362 Q-loop/lid; other site 315750008363 ABC transporter signature motif; other site 315750008364 Walker B; other site 315750008365 D-loop; other site 315750008366 H-loop/switch region; other site 315750008367 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 315750008368 NMT1-like family; Region: NMT1_2; cl15260 315750008369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750008370 dimer interface [polypeptide binding]; other site 315750008371 conserved gate region; other site 315750008372 ABC-ATPase subunit interface; other site 315750008373 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 315750008374 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 315750008375 Walker A/P-loop; other site 315750008376 ATP binding site [chemical binding]; other site 315750008377 Q-loop/lid; other site 315750008378 ABC transporter signature motif; other site 315750008379 Walker B; other site 315750008380 D-loop; other site 315750008381 H-loop/switch region; other site 315750008382 NIL domain; Region: NIL; cl09633 315750008383 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 315750008384 catalytic residues [active] 315750008385 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 315750008386 active site 315750008387 metal binding site [ion binding]; metal-binding site 315750008388 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 315750008389 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 315750008390 lipoyl attachment site [posttranslational modification]; other site 315750008391 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 315750008392 ArsC family; Region: ArsC; pfam03960 315750008393 putative ArsC-like catalytic residues; other site 315750008394 putative TRX-like catalytic residues [active] 315750008395 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 315750008396 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 315750008397 active site 315750008398 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 315750008399 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 315750008400 dimer interface [polypeptide binding]; other site 315750008401 active site 315750008402 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 315750008403 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750008404 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 315750008405 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 315750008406 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 315750008407 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 315750008408 substrate binding site [chemical binding]; other site 315750008409 oxyanion hole (OAH) forming residues; other site 315750008410 trimer interface [polypeptide binding]; other site 315750008411 YuzL-like protein; Region: YuzL; pfam14115 315750008412 Coat F domain; Region: Coat_F; cl15836 315750008413 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 315750008414 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 315750008415 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 315750008416 Walker A/P-loop; other site 315750008417 ATP binding site [chemical binding]; other site 315750008418 Q-loop/lid; other site 315750008419 ABC transporter signature motif; other site 315750008420 Walker B; other site 315750008421 D-loop; other site 315750008422 H-loop/switch region; other site 315750008423 YusW-like protein; Region: YusW; pfam14039 315750008424 short chain dehydrogenase; Provisional; Region: PRK06914 315750008425 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 315750008426 NADP binding site [chemical binding]; other site 315750008427 active site 315750008428 steroid binding site; other site 315750008429 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 315750008430 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 315750008431 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 315750008432 protein binding site [polypeptide binding]; other site 315750008433 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315750008434 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750008435 active site 315750008436 phosphorylation site [posttranslational modification] 315750008437 intermolecular recognition site; other site 315750008438 dimerization interface [polypeptide binding]; other site 315750008439 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315750008440 DNA binding site [nucleotide binding] 315750008441 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315750008442 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315750008443 dimerization interface [polypeptide binding]; other site 315750008444 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315750008445 dimer interface [polypeptide binding]; other site 315750008446 phosphorylation site [posttranslational modification] 315750008447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750008448 ATP binding site [chemical binding]; other site 315750008449 Mg2+ binding site [ion binding]; other site 315750008450 G-X-G motif; other site 315750008451 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750008452 Helix-turn-helix domains; Region: HTH; cl00088 315750008453 fumarate hydratase; Reviewed; Region: fumC; PRK00485 315750008454 Class II fumarases; Region: Fumarase_classII; cd01362 315750008455 active site 315750008456 tetramer interface [polypeptide binding]; other site 315750008457 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 315750008458 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 315750008459 Spore germination protein; Region: Spore_permease; cl15802 315750008460 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 315750008461 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 315750008462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750008463 active site 315750008464 phosphorylation site [posttranslational modification] 315750008465 intermolecular recognition site; other site 315750008466 dimerization interface [polypeptide binding]; other site 315750008467 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 315750008468 DNA binding residues [nucleotide binding] 315750008469 dimerization interface [polypeptide binding]; other site 315750008470 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 315750008471 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315750008472 dimerization interface [polypeptide binding]; other site 315750008473 Histidine kinase; Region: HisKA_3; pfam07730 315750008474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750008475 ATP binding site [chemical binding]; other site 315750008476 Mg2+ binding site [ion binding]; other site 315750008477 G-X-G motif; other site 315750008478 Predicted membrane protein [Function unknown]; Region: COG4758 315750008479 Predicted membrane protein (DUF2157); Region: DUF2157; cl10480 315750008480 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 315750008481 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 315750008482 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 315750008483 PspA/IM30 family; Region: PspA_IM30; pfam04012 315750008484 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 315750008485 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 315750008486 classical (c) SDRs; Region: SDR_c; cd05233 315750008487 NAD(P) binding site [chemical binding]; other site 315750008488 active site 315750008489 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 315750008490 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 315750008491 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 315750008492 Propionate catabolism activator; Region: PrpR_N; pfam06506 315750008493 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 315750008494 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750008495 Walker A motif; other site 315750008496 ATP binding site [chemical binding]; other site 315750008497 Walker B motif; other site 315750008498 arginine finger; other site 315750008499 Helix-turn-helix domains; Region: HTH; cl00088 315750008500 BNR repeat-like domain; Region: BNR_2; pfam13088 315750008501 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 315750008502 catalytic site [active] 315750008503 Asp-box motif; other site 315750008504 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 315750008505 Na binding site [ion binding]; other site 315750008506 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 315750008507 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 315750008508 putative active site [active] 315750008509 metal binding site [ion binding]; metal-binding site 315750008510 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 315750008511 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 315750008512 inhibitor site; inhibition site 315750008513 active site 315750008514 dimer interface [polypeptide binding]; other site 315750008515 catalytic residue [active] 315750008516 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 315750008517 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 315750008518 Walker A/P-loop; other site 315750008519 ATP binding site [chemical binding]; other site 315750008520 Q-loop/lid; other site 315750008521 ABC transporter signature motif; other site 315750008522 Walker B; other site 315750008523 D-loop; other site 315750008524 H-loop/switch region; other site 315750008525 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 315750008526 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315750008527 dimer interface [polypeptide binding]; other site 315750008528 ABC-ATPase subunit interface; other site 315750008529 putative PBP binding regions; other site 315750008530 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 315750008531 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 315750008532 putative binding site residues; other site 315750008533 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 315750008534 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 315750008535 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 315750008536 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 315750008537 Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721 315750008538 altronate oxidoreductase; Provisional; Region: PRK03643 315750008539 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 315750008540 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 315750008541 Transcriptional regulators [Transcription]; Region: PurR; COG1609 315750008542 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315750008543 DNA binding site [nucleotide binding] 315750008544 domain linker motif; other site 315750008545 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 315750008546 dimerization interface [polypeptide binding]; other site 315750008547 ligand binding site [chemical binding]; other site 315750008548 Glucuronate isomerase; Region: UxaC; cl00829 315750008549 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315750008550 dimer interface [polypeptide binding]; other site 315750008551 phosphorylation site [posttranslational modification] 315750008552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750008553 ATP binding site [chemical binding]; other site 315750008554 Mg2+ binding site [ion binding]; other site 315750008555 G-X-G motif; other site 315750008556 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315750008557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750008558 active site 315750008559 phosphorylation site [posttranslational modification] 315750008560 intermolecular recognition site; other site 315750008561 dimerization interface [polypeptide binding]; other site 315750008562 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315750008563 DNA binding site [nucleotide binding] 315750008564 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 315750008565 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 315750008566 Walker A/P-loop; other site 315750008567 ATP binding site [chemical binding]; other site 315750008568 Q-loop/lid; other site 315750008569 ABC transporter signature motif; other site 315750008570 Walker B; other site 315750008571 D-loop; other site 315750008572 H-loop/switch region; other site 315750008573 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 315750008574 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315750008575 ABC-ATPase subunit interface; other site 315750008576 dimer interface [polypeptide binding]; other site 315750008577 putative PBP binding regions; other site 315750008578 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 315750008579 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315750008580 ABC-ATPase subunit interface; other site 315750008581 dimer interface [polypeptide binding]; other site 315750008582 putative PBP binding regions; other site 315750008583 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 315750008584 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 315750008585 putative ligand binding residues [chemical binding]; other site 315750008586 arginine:agmatin antiporter; Provisional; Region: PRK10644 315750008587 Spore germination protein; Region: Spore_permease; cl15802 315750008588 Small spore protein J (Spore_SspJ); Region: Spore_SspJ; cl09798 315750008589 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315750008590 Helix-turn-helix domains; Region: HTH; cl00088 315750008591 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 315750008592 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 315750008593 Sulfatase; Region: Sulfatase; cl10460 315750008594 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 315750008595 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 315750008596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750008597 dimer interface [polypeptide binding]; other site 315750008598 conserved gate region; other site 315750008599 putative PBP binding loops; other site 315750008600 ABC-ATPase subunit interface; other site 315750008601 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 315750008602 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 315750008603 active site 315750008604 catalytic tetrad [active] 315750008605 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 315750008606 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 315750008607 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 315750008608 Predicted membrane protein [Function unknown]; Region: COG2860 315750008609 UPF0126 domain; Region: UPF0126; pfam03458 315750008610 UPF0126 domain; Region: UPF0126; pfam03458 315750008611 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 315750008612 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 315750008613 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 315750008614 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 315750008615 metal-binding site [ion binding] 315750008616 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 315750008617 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 315750008618 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 315750008619 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 315750008620 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315750008621 dimer interface [polypeptide binding]; other site 315750008622 ABC-ATPase subunit interface; other site 315750008623 putative PBP binding regions; other site 315750008624 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 315750008625 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 315750008626 metal binding site [ion binding]; metal-binding site 315750008627 Helix-turn-helix domains; Region: HTH; cl00088 315750008628 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 315750008629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750008630 Response regulator receiver domain; Region: Response_reg; pfam00072 315750008631 active site 315750008632 phosphorylation site [posttranslational modification] 315750008633 intermolecular recognition site; other site 315750008634 dimerization interface [polypeptide binding]; other site 315750008635 YcbB domain; Region: YcbB; pfam08664 315750008636 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315750008637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750008638 ATP binding site [chemical binding]; other site 315750008639 Mg2+ binding site [ion binding]; other site 315750008640 G-X-G motif; other site 315750008641 aspartate ammonia-lyase; Provisional; Region: PRK13353 315750008642 Aspartase; Region: Aspartase; cd01357 315750008643 active sites [active] 315750008644 tetramer interface [polypeptide binding]; other site 315750008645 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 315750008646 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 315750008647 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 315750008648 metal-binding site [ion binding] 315750008649 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 315750008650 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 315750008651 metal-binding site [ion binding] 315750008652 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 315750008653 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 315750008654 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 315750008655 metal-binding site [ion binding] 315750008656 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 315750008657 putative homodimer interface [polypeptide binding]; other site 315750008658 putative homotetramer interface [polypeptide binding]; other site 315750008659 putative allosteric switch controlling residues; other site 315750008660 putative metal binding site [ion binding]; other site 315750008661 putative homodimer-homodimer interface [polypeptide binding]; other site 315750008662 conjugal transfer protein TraV; Provisional; Region: PRK13733 315750008663 Substrate binding subunit of ER-derived-lipid transporter; Provisional; Region: PLN03094 315750008664 sensory histidine kinase AtoS; Provisional; Region: PRK11360 315750008665 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 315750008666 metal binding site [ion binding]; metal-binding site 315750008667 active site 315750008668 I-site; other site 315750008669 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 315750008670 SmpB-tmRNA interface; other site 315750008671 ribonuclease R; Region: RNase_R; TIGR02063 315750008672 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 315750008673 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 315750008674 RNB domain; Region: RNB; pfam00773 315750008675 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 315750008676 RNA binding site [nucleotide binding]; other site 315750008677 Esterase/lipase [General function prediction only]; Region: COG1647 315750008678 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315750008679 Preprotein translocase SecG subunit; Region: SecG; cl09123 315750008680 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 315750008681 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315750008682 salt bridge; other site 315750008683 non-specific DNA binding site [nucleotide binding]; other site 315750008684 sequence-specific DNA binding site [nucleotide binding]; other site 315750008685 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315750008686 non-specific DNA binding site [nucleotide binding]; other site 315750008687 salt bridge; other site 315750008688 sequence-specific DNA binding site [nucleotide binding]; other site 315750008689 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 315750008690 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315750008691 non-specific DNA binding site [nucleotide binding]; other site 315750008692 salt bridge; other site 315750008693 sequence-specific DNA binding site [nucleotide binding]; other site 315750008694 Helix-turn-helix domains; Region: HTH; cl00088 315750008695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750008696 dimer interface [polypeptide binding]; other site 315750008697 conserved gate region; other site 315750008698 putative PBP binding loops; other site 315750008699 ABC-ATPase subunit interface; other site 315750008700 NMT1-like family; Region: NMT1_2; cl15260 315750008701 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 315750008702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750008703 dimer interface [polypeptide binding]; other site 315750008704 conserved gate region; other site 315750008705 putative PBP binding loops; other site 315750008706 ABC-ATPase subunit interface; other site 315750008707 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 315750008708 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 315750008709 Walker A/P-loop; other site 315750008710 ATP binding site [chemical binding]; other site 315750008711 Q-loop/lid; other site 315750008712 ABC transporter signature motif; other site 315750008713 Walker B; other site 315750008714 D-loop; other site 315750008715 H-loop/switch region; other site 315750008716 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 315750008717 Predicted transcriptional regulators [Transcription]; Region: COG1510 315750008718 Helix-turn-helix domains; Region: HTH; cl00088 315750008719 MarC family integral membrane protein; Region: MarC; cl00919 315750008720 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750008721 Coenzyme A binding pocket [chemical binding]; other site 315750008722 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 315750008723 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 315750008724 Walker A/P-loop; other site 315750008725 ATP binding site [chemical binding]; other site 315750008726 Q-loop/lid; other site 315750008727 ABC transporter signature motif; other site 315750008728 Walker B; other site 315750008729 D-loop; other site 315750008730 H-loop/switch region; other site 315750008731 TIGR03503 family protein; Region: TIGR03503 315750008732 enolase; Provisional; Region: eno; PRK00077 315750008733 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 315750008734 dimer interface [polypeptide binding]; other site 315750008735 metal binding site [ion binding]; metal-binding site 315750008736 substrate binding pocket [chemical binding]; other site 315750008737 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 315750008738 Sulfatase; Region: Sulfatase; cl10460 315750008739 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 315750008740 substrate binding site [chemical binding]; other site 315750008741 dimer interface [polypeptide binding]; other site 315750008742 catalytic triad [active] 315750008743 Phosphoglycerate kinase; Region: PGK; pfam00162 315750008744 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 315750008745 substrate binding site [chemical binding]; other site 315750008746 hinge regions; other site 315750008747 ADP binding site [chemical binding]; other site 315750008748 catalytic site [active] 315750008749 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 315750008750 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750008751 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 315750008752 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 315750008753 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 315750008754 S-methylmethionine transporter; Provisional; Region: PRK11387 315750008755 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 315750008756 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315750008757 inhibitor-cofactor binding pocket; inhibition site 315750008758 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750008759 catalytic residue [active] 315750008760 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 315750008761 PAS fold; Region: PAS_4; pfam08448 315750008762 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 315750008763 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315750008764 Walker A motif; other site 315750008765 ATP binding site [chemical binding]; other site 315750008766 Walker B motif; other site 315750008767 arginine finger; other site 315750008768 Helix-turn-helix domains; Region: HTH; cl00088 315750008769 Transcriptional regulators [Transcription]; Region: FadR; COG2186 315750008770 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315750008771 DNA-binding site [nucleotide binding]; DNA binding site 315750008772 FCD domain; Region: FCD; cl11656 315750008773 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 315750008774 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 315750008775 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 315750008776 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 315750008777 YvfG protein; Region: YvfG; pfam09628 315750008778 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 315750008779 MatE; Region: MatE; cl10513 315750008780 MatE; Region: MatE; cl10513 315750008781 nickel import ATP-binding protein NikE; Region: nickel_nikE; TIGR02769 315750008782 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 315750008783 Walker A/P-loop; other site 315750008784 ATP binding site [chemical binding]; other site 315750008785 Q-loop/lid; other site 315750008786 ABC transporter signature motif; other site 315750008787 Walker B; other site 315750008788 D-loop; other site 315750008789 H-loop/switch region; other site 315750008790 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 315750008791 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 315750008792 Walker A/P-loop; other site 315750008793 ATP binding site [chemical binding]; other site 315750008794 Q-loop/lid; other site 315750008795 ABC transporter signature motif; other site 315750008796 Walker B; other site 315750008797 D-loop; other site 315750008798 H-loop/switch region; other site 315750008799 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 315750008800 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 315750008801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750008802 dimer interface [polypeptide binding]; other site 315750008803 conserved gate region; other site 315750008804 putative PBP binding loops; other site 315750008805 ABC-ATPase subunit interface; other site 315750008806 nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789 315750008807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750008808 dimer interface [polypeptide binding]; other site 315750008809 conserved gate region; other site 315750008810 putative PBP binding loops; other site 315750008811 ABC-ATPase subunit interface; other site 315750008812 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 315750008813 substrate binding site [chemical binding]; other site 315750008814 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 315750008815 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 315750008816 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 315750008817 inhibitor-cofactor binding pocket; inhibition site 315750008818 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750008819 catalytic residue [active] 315750008820 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 315750008821 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 315750008822 putative trimer interface [polypeptide binding]; other site 315750008823 putative CoA binding site [chemical binding]; other site 315750008824 Bacterial sugar transferase; Region: Bac_transf; cl00939 315750008825 MatE; Region: MatE; cl10513 315750008826 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 315750008827 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 315750008828 putative glycosyl transferase; Provisional; Region: PRK10073 315750008829 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 315750008830 active site 315750008831 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315750008832 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 315750008833 putative ADP-binding pocket [chemical binding]; other site 315750008834 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 315750008835 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 315750008836 active site 315750008837 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 315750008838 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315750008839 putative ADP-binding pocket [chemical binding]; other site 315750008840 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 315750008841 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 315750008842 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 315750008843 NAD(P) binding site [chemical binding]; other site 315750008844 homodimer interface [polypeptide binding]; other site 315750008845 substrate binding site [chemical binding]; other site 315750008846 active site 315750008847 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 315750008848 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750008849 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 315750008850 Chain length determinant protein; Region: Wzz; cl15801 315750008851 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315750008852 non-specific DNA binding site [nucleotide binding]; other site 315750008853 salt bridge; other site 315750008854 sequence-specific DNA binding site [nucleotide binding]; other site 315750008855 Anti-repressor SinI; Region: SinI; pfam08671 315750008856 Phage lysis protein, holin; Region: Phage_holin; cl04675 315750008857 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 315750008858 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 315750008859 putative ligand binding residues [chemical binding]; other site 315750008860 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315750008861 ABC-ATPase subunit interface; other site 315750008862 dimer interface [polypeptide binding]; other site 315750008863 putative PBP binding regions; other site 315750008864 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315750008865 ABC-ATPase subunit interface; other site 315750008866 dimer interface [polypeptide binding]; other site 315750008867 putative PBP binding regions; other site 315750008868 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 315750008869 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 315750008870 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 315750008871 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 315750008872 ABC transporter; Region: ABC_tran_2; pfam12848 315750008873 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315750008874 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 315750008875 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 315750008876 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 315750008877 Walker A/P-loop; other site 315750008878 ATP binding site [chemical binding]; other site 315750008879 Q-loop/lid; other site 315750008880 ABC transporter signature motif; other site 315750008881 Walker B; other site 315750008882 D-loop; other site 315750008883 H-loop/switch region; other site 315750008884 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 315750008885 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 315750008886 Walker A/P-loop; other site 315750008887 ATP binding site [chemical binding]; other site 315750008888 Q-loop/lid; other site 315750008889 ABC transporter signature motif; other site 315750008890 Walker B; other site 315750008891 D-loop; other site 315750008892 H-loop/switch region; other site 315750008893 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 315750008894 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750008895 dimer interface [polypeptide binding]; other site 315750008896 conserved gate region; other site 315750008897 putative PBP binding loops; other site 315750008898 ABC-ATPase subunit interface; other site 315750008899 nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789 315750008900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750008901 dimer interface [polypeptide binding]; other site 315750008902 conserved gate region; other site 315750008903 putative PBP binding loops; other site 315750008904 ABC-ATPase subunit interface; other site 315750008905 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 315750008906 substrate binding site [chemical binding]; other site 315750008907 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 315750008908 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 315750008909 glycosyltransferase, MGT family; Region: MGT; TIGR01426 315750008910 active site 315750008911 TDP-binding site; other site 315750008912 acceptor substrate-binding pocket; other site 315750008913 homodimer interface [polypeptide binding]; other site 315750008914 TM2 domain; Region: TM2; cl00984 315750008915 Clp protease; Region: CLP_protease; pfam00574 315750008916 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 315750008917 oligomer interface [polypeptide binding]; other site 315750008918 active site residues [active] 315750008919 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 315750008920 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 315750008921 metal binding site [ion binding]; metal-binding site 315750008922 putative transporter; Provisional; Region: PRK11660 315750008923 Sulfate transporter family; Region: Sulfate_transp; cl15842 315750008924 Sulfate transporter family; Region: Sulfate_transp; cl15842 315750008925 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 315750008926 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 315750008927 active site clefts [active] 315750008928 zinc binding site [ion binding]; other site 315750008929 dimer interface [polypeptide binding]; other site 315750008930 glyoxylate reductase; Reviewed; Region: PRK13243 315750008931 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750008932 Barnase, a member of the family of homologous microbial ribonucleases, catalyses the cleavage of single-stranded RNA via a two-step mechanism thought to be similar to that of pancreatic ribonuclease. The mechanism involves a transesterification to give a...; Region: barnase; cd00933 315750008933 active site 315750008934 N-acetyltransferase; Region: Acetyltransf_2; cl00949 315750008935 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 315750008936 dimerization domain swap beta strand [polypeptide binding]; other site 315750008937 regulatory protein interface [polypeptide binding]; other site 315750008938 active site 315750008939 regulatory phosphorylation site [posttranslational modification]; other site 315750008940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 315750008941 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 315750008942 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 315750008943 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 315750008944 phosphate binding site [ion binding]; other site 315750008945 putative substrate binding pocket [chemical binding]; other site 315750008946 dimer interface [polypeptide binding]; other site 315750008947 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 315750008948 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 315750008949 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 315750008950 putative active site [active] 315750008951 nucleotide binding site [chemical binding]; other site 315750008952 nudix motif; other site 315750008953 putative metal binding site [ion binding]; other site 315750008954 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 315750008955 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750008956 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315750008957 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 315750008958 NlpC/P60 family; Region: NLPC_P60; cl11438 315750008959 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750008960 binding surface 315750008961 TPR motif; other site 315750008962 Tetratricopeptide repeat; Region: TPR_16; pfam13432 315750008963 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750008964 TPR motif; other site 315750008965 binding surface 315750008966 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 315750008967 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 315750008968 metal binding site [ion binding]; metal-binding site 315750008969 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 315750008970 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 315750008971 substrate binding site [chemical binding]; other site 315750008972 glutamase interaction surface [polypeptide binding]; other site 315750008973 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 315750008974 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 315750008975 catalytic residues [active] 315750008976 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 315750008977 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 315750008978 putative active site [active] 315750008979 oxyanion strand; other site 315750008980 catalytic triad [active] 315750008981 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 315750008982 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 315750008983 putative active site pocket [active] 315750008984 4-fold oligomerization interface [polypeptide binding]; other site 315750008985 metal binding residues [ion binding]; metal-binding site 315750008986 3-fold/trimer interface [polypeptide binding]; other site 315750008987 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 315750008988 histidinol dehydrogenase; Region: hisD; TIGR00069 315750008989 NAD binding site [chemical binding]; other site 315750008990 dimerization interface [polypeptide binding]; other site 315750008991 product binding site; other site 315750008992 substrate binding site [chemical binding]; other site 315750008993 zinc binding site [ion binding]; other site 315750008994 catalytic residues [active] 315750008995 ATP phosphoribosyltransferase; Region: HisG; cl15266 315750008996 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 315750008997 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 315750008998 dimer interface [polypeptide binding]; other site 315750008999 motif 1; other site 315750009000 active site 315750009001 motif 2; other site 315750009002 motif 3; other site 315750009003 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 315750009004 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 315750009005 putative active site [active] 315750009006 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 315750009007 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 315750009008 catalytic residues [active] 315750009009 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 315750009010 NADH(P)-binding; Region: NAD_binding_10; pfam13460 315750009011 NAD binding site [chemical binding]; other site 315750009012 substrate binding site [chemical binding]; other site 315750009013 putative active site [active] 315750009014 Predicted transcriptional regulator [Transcription]; Region: COG1959 315750009015 Helix-turn-helix domains; Region: HTH; cl00088 315750009016 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 315750009017 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 315750009018 trimer interface [polypeptide binding]; other site 315750009019 active site 315750009020 substrate binding site [chemical binding]; other site 315750009021 CoA binding site [chemical binding]; other site 315750009022 pyrophosphatase PpaX; Provisional; Region: PRK13288 315750009023 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750009024 active site 315750009025 motif I; other site 315750009026 motif II; other site 315750009027 Nucleoside recognition; Region: Gate; cl00486 315750009028 Nucleoside recognition; Region: Gate; cl00486 315750009029 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 315750009030 HPr kinase/phosphorylase; Provisional; Region: PRK05428 315750009031 DRTGG domain; Region: DRTGG; cl12147 315750009032 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 315750009033 Hpr binding site; other site 315750009034 active site 315750009035 homohexamer subunit interaction site [polypeptide binding]; other site 315750009036 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 315750009037 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 315750009038 active site 315750009039 dimer interface [polypeptide binding]; other site 315750009040 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 315750009041 active site 315750009042 trimer interface [polypeptide binding]; other site 315750009043 allosteric site; other site 315750009044 active site lid [active] 315750009045 hexamer (dimer of trimers) interface [polypeptide binding]; other site 315750009046 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 315750009047 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315750009048 DNA-binding site [nucleotide binding]; DNA binding site 315750009049 UTRA domain; Region: UTRA; cl01230 315750009050 Lamin Tail Domain; Region: LTD; pfam00932 315750009051 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 315750009052 putative active site [active] 315750009053 putative metal binding site [ion binding]; other site 315750009054 Membrane protein of unknown function; Region: DUF360; cl00850 315750009055 PspC domain; Region: PspC; cl00864 315750009056 Uncharacterized conserved protein [Function unknown]; Region: COG3595 315750009057 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 315750009058 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 315750009059 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 315750009060 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 315750009061 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 315750009062 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 315750009063 excinuclease ABC subunit B; Provisional; Region: PRK05298 315750009064 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315750009065 ATP binding site [chemical binding]; other site 315750009066 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315750009067 nucleotide binding region [chemical binding]; other site 315750009068 ATP-binding site [chemical binding]; other site 315750009069 Ultra-violet resistance protein B; Region: UvrB; pfam12344 315750009070 UvrB/uvrC motif; Region: UVR; pfam02151 315750009071 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 315750009072 phosphoenolpyruvate synthase; Validated; Region: PRK06241 315750009073 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 315750009074 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 315750009075 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750009076 Helix-turn-helix domains; Region: HTH; cl00088 315750009077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750009078 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315750009079 putative substrate translocation pore; other site 315750009080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750009081 Uncharacterized conserved protein [Function unknown]; Region: COG3391 315750009082 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 315750009083 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 315750009084 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315750009085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750009086 active site 315750009087 phosphorylation site [posttranslational modification] 315750009088 intermolecular recognition site; other site 315750009089 dimerization interface [polypeptide binding]; other site 315750009090 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315750009091 DNA binding site [nucleotide binding] 315750009092 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315750009093 dimerization interface [polypeptide binding]; other site 315750009094 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315750009095 dimer interface [polypeptide binding]; other site 315750009096 phosphorylation site [posttranslational modification] 315750009097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750009098 ATP binding site [chemical binding]; other site 315750009099 Mg2+ binding site [ion binding]; other site 315750009100 G-X-G motif; other site 315750009101 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 315750009102 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 315750009103 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 315750009104 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 315750009105 Ligand binding site; other site 315750009106 Putative Catalytic site; other site 315750009107 DXD motif; other site 315750009108 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 315750009109 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 315750009110 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 315750009111 dimer interface [polypeptide binding]; other site 315750009112 FMN binding site [chemical binding]; other site 315750009113 Helix-turn-helix domains; Region: HTH; cl00088 315750009114 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 315750009115 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 315750009116 C-terminal peptidase (prc); Region: prc; TIGR00225 315750009117 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 315750009118 protein binding site [polypeptide binding]; other site 315750009119 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 315750009120 Catalytic dyad [active] 315750009121 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 315750009122 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 315750009123 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 315750009124 Peptidase family M23; Region: Peptidase_M23; pfam01551 315750009125 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 315750009126 FtsX-like permease family; Region: FtsX; cl15850 315750009127 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 315750009128 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750009129 Walker A/P-loop; other site 315750009130 ATP binding site [chemical binding]; other site 315750009131 Q-loop/lid; other site 315750009132 ABC transporter signature motif; other site 315750009133 Walker B; other site 315750009134 D-loop; other site 315750009135 H-loop/switch region; other site 315750009136 Cytochrome c; Region: Cytochrom_C; cl11414 315750009137 Uncharacterized conserved protein [Function unknown]; Region: COG1284 315750009138 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315750009139 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315750009140 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 315750009141 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 315750009142 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 315750009143 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 315750009144 active site 315750009145 Zn binding site [ion binding]; other site 315750009146 peptide chain release factor 2; Provisional; Region: PRK06746 315750009147 RF-1 domain; Region: RF-1; cl02875 315750009148 RF-1 domain; Region: RF-1; cl02875 315750009149 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 315750009150 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 315750009151 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315750009152 nucleotide binding region [chemical binding]; other site 315750009153 ATP-binding site [chemical binding]; other site 315750009154 SEC-C motif; Region: SEC-C; pfam02810 315750009155 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 315750009156 30S subunit binding site; other site 315750009157 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 315750009158 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315750009159 dimerization interface [polypeptide binding]; other site 315750009160 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750009161 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315750009162 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750009163 dimer interface [polypeptide binding]; other site 315750009164 putative CheW interface [polypeptide binding]; other site 315750009165 Flagellar protein FliS; Region: FliS; cl00654 315750009166 flagellar capping protein; Validated; Region: fliD; PRK07737 315750009167 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 315750009168 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 315750009169 FlaG protein; Region: FlaG; cl00591 315750009170 Global regulator protein family; Region: CsrA; cl00670 315750009171 FliW protein; Region: FliW; cl00740 315750009172 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 315750009173 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 315750009174 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 315750009175 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 315750009176 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 315750009177 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 315750009178 FlgN protein; Region: FlgN; cl09176 315750009179 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 315750009180 flagellar operon protein TIGR03826; Region: YvyF 315750009181 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 315750009182 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315750009183 Late competence development protein ComFB; Region: ComFB; pfam10719 315750009184 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 315750009185 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315750009186 ATP binding site [chemical binding]; other site 315750009187 putative Mg++ binding site [ion binding]; other site 315750009188 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315750009189 nucleotide binding region [chemical binding]; other site 315750009190 ATP-binding site [chemical binding]; other site 315750009191 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 315750009192 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 315750009193 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750009194 active site 315750009195 phosphorylation site [posttranslational modification] 315750009196 intermolecular recognition site; other site 315750009197 dimerization interface [polypeptide binding]; other site 315750009198 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 315750009199 DNA binding residues [nucleotide binding] 315750009200 dimerization interface [polypeptide binding]; other site 315750009201 Sensor protein DegS; Region: DegS; pfam05384 315750009202 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 315750009203 Histidine kinase; Region: HisKA_3; pfam07730 315750009204 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750009205 ATP binding site [chemical binding]; other site 315750009206 Mg2+ binding site [ion binding]; other site 315750009207 G-X-G motif; other site 315750009208 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 315750009209 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 315750009210 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 315750009211 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 315750009212 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 315750009213 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 315750009214 Mg++ binding site [ion binding]; other site 315750009215 putative catalytic motif [active] 315750009216 substrate binding site [chemical binding]; other site 315750009217 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 315750009218 putative homodimer interface [polypeptide binding]; other site 315750009219 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 315750009220 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 315750009221 active site 315750009222 O-Antigen ligase; Region: Wzy_C; cl04850 315750009223 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 315750009224 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750009225 NAD(P) binding site [chemical binding]; other site 315750009226 active site 315750009227 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 315750009228 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750009229 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 315750009230 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750009231 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 315750009232 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 315750009233 colanic acid exporter; Provisional; Region: PRK10459 315750009234 MatE; Region: MatE; cl10513 315750009235 Bacterial sugar transferase; Region: Bac_transf; cl00939 315750009236 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 315750009237 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 315750009238 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 315750009239 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 315750009240 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 315750009241 active site 315750009242 metal binding site [ion binding]; metal-binding site 315750009243 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 315750009244 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 315750009245 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 315750009246 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 315750009247 Stage II sporulation protein; Region: SpoIID; pfam08486 315750009248 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 315750009249 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 315750009250 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 315750009251 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 315750009252 active site 315750009253 homodimer interface [polypeptide binding]; other site 315750009254 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 315750009255 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 315750009256 active site 315750009257 tetramer interface; other site 315750009258 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 315750009259 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 315750009260 Walker A/P-loop; other site 315750009261 ATP binding site [chemical binding]; other site 315750009262 Q-loop/lid; other site 315750009263 ABC transporter signature motif; other site 315750009264 Walker B; other site 315750009265 D-loop; other site 315750009266 H-loop/switch region; other site 315750009267 ABC-2 type transporter; Region: ABC2_membrane; cl11417 315750009268 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 315750009269 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 315750009270 active site 315750009271 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 315750009272 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 315750009273 inhibitor-cofactor binding pocket; inhibition site 315750009274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750009275 catalytic residue [active] 315750009276 ATP-grasp domain; Region: ATP-grasp_4; cl03087 315750009277 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 315750009278 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 315750009279 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 315750009280 NAD binding site [chemical binding]; other site 315750009281 substrate binding site [chemical binding]; other site 315750009282 homodimer interface [polypeptide binding]; other site 315750009283 active site 315750009284 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 315750009285 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 315750009286 substrate binding site; other site 315750009287 tetramer interface; other site 315750009288 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 315750009289 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 315750009290 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 315750009291 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 315750009292 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 315750009293 active site 315750009294 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 315750009295 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 315750009296 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 315750009297 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 315750009298 Bacterial SH3 domain; Region: SH3_3; cl02551 315750009299 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 315750009300 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 315750009301 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 315750009302 SH3-like domain; Region: SH3_8; pfam13457 315750009303 SH3-like domain; Region: SH3_8; pfam13457 315750009304 SH3-like domain; Region: SH3_8; pfam13457 315750009305 SH3-like domain; Region: SH3_8; pfam13457 315750009306 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 315750009307 putative ADP-binding pocket [chemical binding]; other site 315750009308 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 315750009309 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 315750009310 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 315750009311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750009312 dimer interface [polypeptide binding]; other site 315750009313 conserved gate region; other site 315750009314 putative PBP binding loops; other site 315750009315 ABC-ATPase subunit interface; other site 315750009316 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 315750009317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750009318 dimer interface [polypeptide binding]; other site 315750009319 ABC-ATPase subunit interface; other site 315750009320 putative PBP binding loops; other site 315750009321 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 315750009322 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 315750009323 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 315750009324 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 315750009325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750009326 active site 315750009327 phosphorylation site [posttranslational modification] 315750009328 intermolecular recognition site; other site 315750009329 dimerization interface [polypeptide binding]; other site 315750009330 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315750009331 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315750009332 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 315750009333 Histidine kinase; Region: His_kinase; pfam06580 315750009334 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750009335 ATP binding site [chemical binding]; other site 315750009336 Mg2+ binding site [ion binding]; other site 315750009337 G-X-G motif; other site 315750009338 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 315750009339 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 315750009340 ligand binding site [chemical binding]; other site 315750009341 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 315750009342 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750009343 Coenzyme A binding pocket [chemical binding]; other site 315750009344 KDPG and KHG aldolase; Region: Aldolase; pfam01081 315750009345 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 315750009346 active site 315750009347 intersubunit interface [polypeptide binding]; other site 315750009348 catalytic residue [active] 315750009349 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 315750009350 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 315750009351 substrate binding site [chemical binding]; other site 315750009352 ATP binding site [chemical binding]; other site 315750009353 Transcriptional regulators [Transcription]; Region: PurR; COG1609 315750009354 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315750009355 DNA binding site [nucleotide binding] 315750009356 domain linker motif; other site 315750009357 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 315750009358 putative dimerization interface [polypeptide binding]; other site 315750009359 putative ligand binding site [chemical binding]; other site 315750009360 KduI/IolB family; Region: KduI; cl01508 315750009361 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 315750009362 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 315750009363 NADP binding site [chemical binding]; other site 315750009364 homodimer interface [polypeptide binding]; other site 315750009365 active site 315750009366 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 315750009367 Spore germination protein; Region: Spore_permease; cl15802 315750009368 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 315750009369 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 315750009370 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 315750009371 Probable Catalytic site; other site 315750009372 metal-binding site 315750009373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750009374 S-adenosylmethionine binding site [chemical binding]; other site 315750009375 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 315750009376 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750009377 putative substrate translocation pore; other site 315750009378 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 315750009379 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 315750009380 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750009381 active site 315750009382 motif I; other site 315750009383 motif II; other site 315750009384 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750009385 NlpC/P60 family; Region: NLPC_P60; cl11438 315750009386 NlpC/P60 family; Region: NLPC_P60; cl11438 315750009387 NlpC/P60 family; Region: NLPC_P60; cl11438 315750009388 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 315750009389 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 315750009390 putative active site [active] 315750009391 putative metal binding site [ion binding]; other site 315750009392 Capsule biosynthesis CapC; Region: Caps_synth_CapC; cl14855 315750009393 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 315750009394 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 315750009395 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 315750009396 Spore germination protein; Region: Spore_permease; cl15802 315750009397 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 315750009398 Transcriptional regulators [Transcription]; Region: PurR; COG1609 315750009399 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315750009400 DNA binding site [nucleotide binding] 315750009401 domain linker motif; other site 315750009402 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 315750009403 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 315750009404 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 315750009405 substrate binding site [chemical binding]; other site 315750009406 dimer interface [polypeptide binding]; other site 315750009407 ATP binding site [chemical binding]; other site 315750009408 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 315750009409 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 315750009410 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 315750009411 Walker A/P-loop; other site 315750009412 ATP binding site [chemical binding]; other site 315750009413 Q-loop/lid; other site 315750009414 ABC transporter signature motif; other site 315750009415 Walker B; other site 315750009416 D-loop; other site 315750009417 H-loop/switch region; other site 315750009418 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 315750009419 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 315750009420 TM-ABC transporter signature motif; other site 315750009421 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 315750009422 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 315750009423 ligand binding site [chemical binding]; other site 315750009424 dimerization interface [polypeptide binding]; other site 315750009425 Flavin Reductases; Region: FlaRed; cl00801 315750009426 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 315750009427 Helix-turn-helix domains; Region: HTH; cl00088 315750009428 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 315750009429 dimerization interface [polypeptide binding]; other site 315750009430 acetolactate synthase; Reviewed; Region: PRK08617 315750009431 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 315750009432 PYR/PP interface [polypeptide binding]; other site 315750009433 dimer interface [polypeptide binding]; other site 315750009434 TPP binding site [chemical binding]; other site 315750009435 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 315750009436 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 315750009437 TPP-binding site [chemical binding]; other site 315750009438 dimer interface [polypeptide binding]; other site 315750009439 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 315750009440 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 315750009441 Helix-turn-helix domains; Region: HTH; cl00088 315750009442 AsnC family; Region: AsnC_trans_reg; pfam01037 315750009443 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 315750009444 Chromate transporter; Region: Chromate_transp; pfam02417 315750009445 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 315750009446 Chromate transporter; Region: Chromate_transp; pfam02417 315750009447 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 315750009448 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750009449 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 315750009450 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750009451 SWIM zinc finger; Region: SWIM; cl15408 315750009452 SNF2 Helicase protein; Region: DUF3670; pfam12419 315750009453 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 315750009454 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315750009455 ATP binding site [chemical binding]; other site 315750009456 putative Mg++ binding site [ion binding]; other site 315750009457 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315750009458 nucleotide binding region [chemical binding]; other site 315750009459 ATP-binding site [chemical binding]; other site 315750009460 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315750009461 PAS domain; Region: PAS_9; pfam13426 315750009462 putative active site [active] 315750009463 heme pocket [chemical binding]; other site 315750009464 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 315750009465 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 315750009466 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750009467 motif II; other site 315750009468 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750009469 YwpF-like protein; Region: YwpF; pfam14183 315750009470 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 315750009471 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 315750009472 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 315750009473 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315750009474 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 315750009475 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 315750009476 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 315750009477 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 315750009478 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 315750009479 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 315750009480 rod shape-determining protein Mbl; Provisional; Region: PRK13928 315750009481 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 315750009482 ATP binding site [chemical binding]; other site 315750009483 profilin binding site; other site 315750009484 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 315750009485 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315750009486 Helix-turn-helix domains; Region: HTH; cl00088 315750009487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750009488 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315750009489 putative substrate translocation pore; other site 315750009490 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 315750009491 active site 315750009492 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750009493 D-galactonate transporter; Region: 2A0114; TIGR00893 315750009494 putative substrate translocation pore; other site 315750009495 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750009496 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 315750009497 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 315750009498 substrate binding pocket [chemical binding]; other site 315750009499 membrane-bound complex binding site; other site 315750009500 hinge residues; other site 315750009501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750009502 dimer interface [polypeptide binding]; other site 315750009503 conserved gate region; other site 315750009504 putative PBP binding loops; other site 315750009505 ABC-ATPase subunit interface; other site 315750009506 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 315750009507 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 315750009508 Walker A/P-loop; other site 315750009509 ATP binding site [chemical binding]; other site 315750009510 Q-loop/lid; other site 315750009511 ABC transporter signature motif; other site 315750009512 Walker B; other site 315750009513 D-loop; other site 315750009514 H-loop/switch region; other site 315750009515 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 315750009516 Nitrogen regulatory protein P-II; Region: P-II; cl00412 315750009517 Nitrogen regulatory protein P-II; Region: P-II; smart00938 315750009518 Peptidase family M23; Region: Peptidase_M23; pfam01551 315750009519 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 315750009520 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750009521 Coenzyme A binding pocket [chemical binding]; other site 315750009522 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 315750009523 DoxX; Region: DoxX; cl00976 315750009524 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 315750009525 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 315750009526 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750009527 Walker A/P-loop; other site 315750009528 ATP binding site [chemical binding]; other site 315750009529 Q-loop/lid; other site 315750009530 ABC transporter signature motif; other site 315750009531 Walker B; other site 315750009532 D-loop; other site 315750009533 H-loop/switch region; other site 315750009534 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 315750009535 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 315750009536 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750009537 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 315750009538 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 315750009539 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 315750009540 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315750009541 FeS/SAM binding site; other site 315750009542 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 315750009543 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 315750009544 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 315750009545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750009546 putative substrate translocation pore; other site 315750009547 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 315750009548 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 315750009549 molybdopterin cofactor binding site; other site 315750009550 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 315750009551 putative molybdopterin cofactor binding site; other site 315750009552 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 315750009553 metal ion-dependent adhesion site (MIDAS); other site 315750009554 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 315750009555 metal ion-dependent adhesion site (MIDAS); other site 315750009556 stage II sporulation protein D; Region: spore_II_D; TIGR02870 315750009557 Stage II sporulation protein; Region: SpoIID; pfam08486 315750009558 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 315750009559 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 315750009560 hinge; other site 315750009561 active site 315750009562 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 315750009563 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 315750009564 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 315750009565 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 315750009566 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 315750009567 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 315750009568 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 315750009569 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 315750009570 alpha subunit interaction interface [polypeptide binding]; other site 315750009571 Walker A motif; other site 315750009572 ATP binding site [chemical binding]; other site 315750009573 Walker B motif; other site 315750009574 inhibitor binding site; inhibition site 315750009575 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 315750009576 ATP synthase; Region: ATP-synt; cl00365 315750009577 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 315750009578 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 315750009579 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 315750009580 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 315750009581 beta subunit interaction interface [polypeptide binding]; other site 315750009582 Walker A motif; other site 315750009583 ATP binding site [chemical binding]; other site 315750009584 Walker B motif; other site 315750009585 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 315750009586 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 315750009587 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 315750009588 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 315750009589 ATP synthase subunit C; Region: ATP-synt_C; cl00466 315750009590 ATP synthase A chain; Region: ATP-synt_A; cl00413 315750009591 ATP synthase I chain; Region: ATP_synt_I; cl09170 315750009592 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315750009593 active site 315750009594 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 315750009595 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 315750009596 dimer interface [polypeptide binding]; other site 315750009597 active site 315750009598 glycine-pyridoxal phosphate binding site [chemical binding]; other site 315750009599 folate binding site [chemical binding]; other site 315750009600 Protein of unknown function (DUF436); Region: DUF436; cl01860 315750009601 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 315750009602 Low molecular weight phosphatase family; Region: LMWPc; cd00115 315750009603 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 315750009604 active site 315750009605 Domain of unknown function DUF; Region: DUF204; pfam02659 315750009606 Domain of unknown function DUF; Region: DUF204; pfam02659 315750009607 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 315750009608 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 315750009609 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315750009610 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775 315750009611 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 315750009612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750009613 S-adenosylmethionine binding site [chemical binding]; other site 315750009614 peptide chain release factor 1; Validated; Region: prfA; PRK00591 315750009615 RF-1 domain; Region: RF-1; cl02875 315750009616 RF-1 domain; Region: RF-1; cl02875 315750009617 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 315750009618 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 315750009619 DNA binding residues [nucleotide binding] 315750009620 Membrane transport protein; Region: Mem_trans; cl09117 315750009621 malate dehydrogenase; Provisional; Region: PRK13529 315750009622 Malic enzyme, N-terminal domain; Region: malic; pfam00390 315750009623 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 315750009624 NAD(P) binding site [chemical binding]; other site 315750009625 thymidine kinase; Provisional; Region: PRK04296 315750009626 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 315750009627 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 315750009628 putative active site [active] 315750009629 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 315750009630 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 315750009631 hinge; other site 315750009632 active site 315750009633 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 315750009634 active site 315750009635 intersubunit interactions; other site 315750009636 catalytic residue [active] 315750009637 hypothetical protein; Provisional; Region: PRK08185 315750009638 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 315750009639 intersubunit interface [polypeptide binding]; other site 315750009640 active site 315750009641 zinc binding site [ion binding]; other site 315750009642 Na+ binding site [ion binding]; other site 315750009643 Response regulator receiver domain; Region: Response_reg; pfam00072 315750009644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750009645 active site 315750009646 phosphorylation site [posttranslational modification] 315750009647 intermolecular recognition site; other site 315750009648 dimerization interface [polypeptide binding]; other site 315750009649 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 315750009650 CTP synthetase; Validated; Region: pyrG; PRK05380 315750009651 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 315750009652 Catalytic site [active] 315750009653 active site 315750009654 UTP binding site [chemical binding]; other site 315750009655 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 315750009656 active site 315750009657 putative oxyanion hole; other site 315750009658 catalytic triad [active] 315750009659 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 315750009660 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750009661 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 315750009662 Walker A/P-loop; other site 315750009663 ATP binding site [chemical binding]; other site 315750009664 Q-loop/lid; other site 315750009665 ABC transporter signature motif; other site 315750009666 Walker B; other site 315750009667 D-loop; other site 315750009668 H-loop/switch region; other site 315750009669 Integral membrane protein DUF95; Region: DUF95; cl00572 315750009670 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 315750009671 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 315750009672 FAD binding site [chemical binding]; other site 315750009673 homotetramer interface [polypeptide binding]; other site 315750009674 substrate binding pocket [chemical binding]; other site 315750009675 catalytic base [active] 315750009676 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 315750009677 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 315750009678 active site 315750009679 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 315750009680 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750009681 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 315750009682 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 315750009683 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 315750009684 dimer interface [polypeptide binding]; other site 315750009685 active site 315750009686 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 315750009687 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 315750009688 Cysteine-rich domain; Region: CCG; pfam02754 315750009689 Cysteine-rich domain; Region: CCG; pfam02754 315750009690 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 315750009691 putative active site [active] 315750009692 catalytic site [active] 315750009693 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 315750009694 PLD-like domain; Region: PLDc_2; pfam13091 315750009695 putative active site [active] 315750009696 catalytic site [active] 315750009697 UV-endonuclease UvdE; Region: UvdE; cl10036 315750009698 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 315750009699 putative dimer interface [polypeptide binding]; other site 315750009700 catalytic triad [active] 315750009701 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 315750009702 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 315750009703 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 315750009704 Walker A/P-loop; other site 315750009705 ATP binding site [chemical binding]; other site 315750009706 Q-loop/lid; other site 315750009707 ABC transporter signature motif; other site 315750009708 Walker B; other site 315750009709 D-loop; other site 315750009710 H-loop/switch region; other site 315750009711 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 315750009712 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 315750009713 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 315750009714 putative active site [active] 315750009715 catalytic site [active] 315750009716 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 315750009717 putative active site [active] 315750009718 catalytic site [active] 315750009719 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 315750009720 putative dimer interface [polypeptide binding]; other site 315750009721 catalytic triad [active] 315750009722 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 315750009723 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 315750009724 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 315750009725 active site 315750009726 HIGH motif; other site 315750009727 KMSK motif region; other site 315750009728 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 315750009729 tRNA binding surface [nucleotide binding]; other site 315750009730 anticodon binding site; other site 315750009731 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 315750009732 Arginase family; Region: Arginase; cl00306 315750009733 spermidine synthase; Provisional; Region: PRK00811 315750009734 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750009735 Transglycosylase; Region: Transgly; cl07896 315750009736 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 315750009737 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315750009738 YwhD family; Region: YwhD; pfam08741 315750009739 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 315750009740 active site 315750009741 putative substrate binding region [chemical binding]; other site 315750009742 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 315750009743 active site 1 [active] 315750009744 dimer interface [polypeptide binding]; other site 315750009745 hexamer interface [polypeptide binding]; other site 315750009746 active site 2 [active] 315750009747 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 315750009748 active site 315750009749 Uncharacterized conserved protein [Function unknown]; Region: COG3465 315750009750 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 315750009751 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 315750009752 Zn2+ binding site [ion binding]; other site 315750009753 Mg2+ binding site [ion binding]; other site 315750009754 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 315750009755 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 315750009756 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 315750009757 cellulose synthase A (UDP-forming), catalytic subunit; Region: PLN02638 315750009758 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 315750009759 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 315750009760 DXD motif; other site 315750009761 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 315750009762 PilZ domain; Region: PilZ; cl01260 315750009763 PilZ domain; Region: PilZ; cl01260 315750009764 TPR repeat; Region: TPR_11; pfam13414 315750009765 Tetratrico peptide repeat; Region: TPR_5; pfam12688 315750009766 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315750009767 binding surface 315750009768 TPR motif; other site 315750009769 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 315750009770 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 315750009771 LXG domain of WXG superfamily; Region: LXG; pfam04740 315750009772 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 315750009773 Cytotoxic; Region: Cytotoxic; pfam09000 315750009774 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 315750009775 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 315750009776 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750009777 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 315750009778 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 315750009779 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 315750009780 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 315750009781 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 315750009782 putative active site [active] 315750009783 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 315750009784 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 315750009785 Chlorite dismutase; Region: Chlor_dismutase; cl01280 315750009786 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 315750009787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750009788 putative substrate translocation pore; other site 315750009789 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 315750009790 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315750009791 putative DNA binding site [nucleotide binding]; other site 315750009792 putative Zn2+ binding site [ion binding]; other site 315750009793 AsnC family; Region: AsnC_trans_reg; pfam01037 315750009794 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 315750009795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750009796 putative substrate translocation pore; other site 315750009797 Prephenate dehydratase; Region: PDT; pfam00800 315750009798 Cupin domain; Region: Cupin_2; cl09118 315750009799 Cupin domain; Region: Cupin_2; cl09118 315750009800 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 315750009801 classical (c) SDRs; Region: SDR_c; cd05233 315750009802 NAD(P) binding site [chemical binding]; other site 315750009803 active site 315750009804 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 315750009805 ATP-grasp domain; Region: ATP-grasp_4; cl03087 315750009806 transaminase; Reviewed; Region: PRK08068 315750009807 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315750009808 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750009809 homodimer interface [polypeptide binding]; other site 315750009810 catalytic residue [active] 315750009811 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 315750009812 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750009813 NAD(P) binding site [chemical binding]; other site 315750009814 active site 315750009815 Cupin domain; Region: Cupin_2; cl09118 315750009816 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 315750009817 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 315750009818 NADP binding site [chemical binding]; other site 315750009819 active site 315750009820 putative substrate binding site [chemical binding]; other site 315750009821 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 315750009822 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 315750009823 NAD binding site [chemical binding]; other site 315750009824 substrate binding site [chemical binding]; other site 315750009825 homodimer interface [polypeptide binding]; other site 315750009826 active site 315750009827 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 315750009828 active site 315750009829 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 315750009830 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 315750009831 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 315750009832 ligand binding site; other site 315750009833 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 315750009834 NeuB family; Region: NeuB; cl00496 315750009835 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 315750009836 NeuB binding interface [polypeptide binding]; other site 315750009837 putative substrate binding site [chemical binding]; other site 315750009838 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315750009839 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750009840 Coenzyme A binding pocket [chemical binding]; other site 315750009841 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 315750009842 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 315750009843 inhibitor-cofactor binding pocket; inhibition site 315750009844 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315750009845 catalytic residue [active] 315750009846 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 315750009847 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 315750009848 active site 315750009849 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; cl09881 315750009850 Cupin domain; Region: Cupin_2; cl09118 315750009851 Protein of unknown function (DUF423); Region: DUF423; cl01008 315750009852 Permease family; Region: Xan_ur_permease; pfam00860 315750009853 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 315750009854 ligand binding site [chemical binding]; other site 315750009855 active site 315750009856 UGI interface [polypeptide binding]; other site 315750009857 catalytic site [active] 315750009858 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 315750009859 active site 315750009860 Heat induced stress protein YflT; Region: YflT; pfam11181 315750009861 Heat induced stress protein YflT; Region: YflT; pfam11181 315750009862 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 315750009863 dimer interface [polypeptide binding]; other site 315750009864 substrate binding site [chemical binding]; other site 315750009865 ATP binding site [chemical binding]; other site 315750009866 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 315750009867 Predicted peptidase [General function prediction only]; Region: COG4099 315750009868 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 315750009869 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 315750009870 substrate binding [chemical binding]; other site 315750009871 active site 315750009872 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 315750009873 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 315750009874 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 315750009875 active site turn [active] 315750009876 phosphorylation site [posttranslational modification] 315750009877 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 315750009878 transcriptional antiterminator BglG; Provisional; Region: PRK09772 315750009879 CAT RNA binding domain; Region: CAT_RBD; cl03904 315750009880 PRD domain; Region: PRD; cl15445 315750009881 PRD domain; Region: PRD; cl15445 315750009882 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 315750009883 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 315750009884 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 315750009885 putative active site [active] 315750009886 catalytic triad [active] 315750009887 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 315750009888 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 315750009889 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 315750009890 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 315750009891 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 315750009892 dimer interface [polypeptide binding]; other site 315750009893 FMN binding site [chemical binding]; other site 315750009894 NADPH bind site [chemical binding]; other site 315750009895 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 315750009896 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 315750009897 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 315750009898 Subunit I/III interface [polypeptide binding]; other site 315750009899 Subunit III/IV interface [polypeptide binding]; other site 315750009900 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 315750009901 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 315750009902 D-pathway; other site 315750009903 Putative ubiquinol binding site [chemical binding]; other site 315750009904 Low-spin heme (heme b) binding site [chemical binding]; other site 315750009905 Putative water exit pathway; other site 315750009906 Binuclear center (heme o3/CuB) [ion binding]; other site 315750009907 K-pathway; other site 315750009908 Putative proton exit pathway; other site 315750009909 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 315750009910 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 315750009911 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 315750009912 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 315750009913 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 315750009914 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 315750009915 active site 315750009916 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 315750009917 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 315750009918 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 315750009919 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 315750009920 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 315750009921 NAD binding site [chemical binding]; other site 315750009922 homodimer interface [polypeptide binding]; other site 315750009923 active site 315750009924 substrate binding site [chemical binding]; other site 315750009925 galactokinase; Provisional; Region: PRK05322 315750009926 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 315750009927 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 315750009928 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 315750009929 Cupin domain; Region: Cupin_2; cl09118 315750009930 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315750009931 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 315750009932 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315750009933 GtrA-like protein; Region: GtrA; cl00971 315750009934 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 315750009935 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750009936 S-adenosylmethionine binding site [chemical binding]; other site 315750009937 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 315750009938 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315750009939 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315750009940 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 315750009941 methionine aminopeptidase 2; Provisional; Region: PTZ00053 315750009942 Protein of unknown function, DUF485; Region: DUF485; cl01231 315750009943 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 315750009944 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 315750009945 Na binding site [ion binding]; other site 315750009946 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 315750009947 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 315750009948 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 315750009949 thiamine phosphate binding site [chemical binding]; other site 315750009950 active site 315750009951 pyrophosphate binding site [ion binding]; other site 315750009952 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 315750009953 substrate binding site [chemical binding]; other site 315750009954 multimerization interface [polypeptide binding]; other site 315750009955 ATP binding site [chemical binding]; other site 315750009956 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315750009957 Helix-turn-helix domains; Region: HTH; cl00088 315750009958 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 315750009959 putative dimerization interface [polypeptide binding]; other site 315750009960 LrgA family; Region: LrgA; cl00608 315750009961 LrgB-like family; Region: LrgB; cl00596 315750009962 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 315750009963 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 315750009964 putative RNA binding site [nucleotide binding]; other site 315750009965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 315750009966 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315750009967 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 315750009968 active site 315750009969 metal binding site [ion binding]; metal-binding site 315750009970 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 315750009971 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 315750009972 Walker A/P-loop; other site 315750009973 ATP binding site [chemical binding]; other site 315750009974 Q-loop/lid; other site 315750009975 ABC transporter signature motif; other site 315750009976 Walker B; other site 315750009977 D-loop; other site 315750009978 H-loop/switch region; other site 315750009979 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315750009980 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 315750009981 synthetase active site [active] 315750009982 NTP binding site [chemical binding]; other site 315750009983 metal binding site [ion binding]; metal-binding site 315750009984 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 315750009985 TM-ABC transporter signature motif; other site 315750009986 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 315750009987 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 315750009988 Walker A/P-loop; other site 315750009989 ATP binding site [chemical binding]; other site 315750009990 Q-loop/lid; other site 315750009991 ABC transporter signature motif; other site 315750009992 Walker B; other site 315750009993 D-loop; other site 315750009994 H-loop/switch region; other site 315750009995 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 315750009996 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 315750009997 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 315750009998 putative ligand binding site [chemical binding]; other site 315750009999 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 315750010000 Pectinesterase; Region: Pectinesterase; cl01911 315750010001 Right handed beta helix region; Region: Beta_helix; pfam13229 315750010002 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 315750010003 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 315750010004 homodimer interface [polypeptide binding]; other site 315750010005 substrate-cofactor binding pocket; other site 315750010006 catalytic residue [active] 315750010007 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 315750010008 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 315750010009 NAD binding site [chemical binding]; other site 315750010010 sugar binding site [chemical binding]; other site 315750010011 divalent metal binding site [ion binding]; other site 315750010012 tetramer (dimer of dimers) interface [polypeptide binding]; other site 315750010013 dimer interface [polypeptide binding]; other site 315750010014 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 315750010015 methionine cluster; other site 315750010016 active site 315750010017 phosphorylation site [posttranslational modification] 315750010018 metal binding site [ion binding]; metal-binding site 315750010019 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 315750010020 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 315750010021 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 315750010022 active site 315750010023 P-loop; other site 315750010024 phosphorylation site [posttranslational modification] 315750010025 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 315750010026 Helix-turn-helix domains; Region: HTH; cl00088 315750010027 Helix-turn-helix domains; Region: HTH; cl00088 315750010028 PRD domain; Region: PRD; cl15445 315750010029 PRD domain; Region: PRD; cl15445 315750010030 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 315750010031 active site 315750010032 P-loop; other site 315750010033 phosphorylation site [posttranslational modification] 315750010034 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 315750010035 active site 315750010036 phosphorylation site [posttranslational modification] 315750010037 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 315750010038 active site 315750010039 putative catalytic site [active] 315750010040 glutamate dehydrogenase; Provisional; Region: PRK09414 315750010041 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 315750010042 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 315750010043 NAD(P) binding site [chemical binding]; other site 315750010044 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 315750010045 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315750010046 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315750010047 DNA binding residues [nucleotide binding] 315750010048 Pectate lyase; Region: Pec_lyase_C; cl01593 315750010049 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 315750010050 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 315750010051 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750010052 Walker A/P-loop; other site 315750010053 ATP binding site [chemical binding]; other site 315750010054 Q-loop/lid; other site 315750010055 ABC transporter signature motif; other site 315750010056 Walker B; other site 315750010057 D-loop; other site 315750010058 H-loop/switch region; other site 315750010059 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 315750010060 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 315750010061 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750010062 Walker A/P-loop; other site 315750010063 ATP binding site [chemical binding]; other site 315750010064 Q-loop/lid; other site 315750010065 ABC transporter signature motif; other site 315750010066 Walker B; other site 315750010067 D-loop; other site 315750010068 H-loop/switch region; other site 315750010069 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 315750010070 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 315750010071 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 315750010072 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 315750010073 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 315750010074 Walker A/P-loop; other site 315750010075 ATP binding site [chemical binding]; other site 315750010076 Q-loop/lid; other site 315750010077 ABC transporter signature motif; other site 315750010078 Walker B; other site 315750010079 D-loop; other site 315750010080 H-loop/switch region; other site 315750010081 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 315750010082 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315750010083 ABC-ATPase subunit interface; other site 315750010084 dimer interface [polypeptide binding]; other site 315750010085 putative PBP binding regions; other site 315750010086 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 315750010087 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 315750010088 intersubunit interface [polypeptide binding]; other site 315750010089 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 315750010090 active site 315750010091 catalytic site [active] 315750010092 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 315750010093 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 315750010094 Walker A/P-loop; other site 315750010095 ATP binding site [chemical binding]; other site 315750010096 Q-loop/lid; other site 315750010097 ABC transporter signature motif; other site 315750010098 Walker B; other site 315750010099 D-loop; other site 315750010100 H-loop/switch region; other site 315750010101 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315750010102 ABC-ATPase subunit interface; other site 315750010103 dimer interface [polypeptide binding]; other site 315750010104 putative PBP binding regions; other site 315750010105 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 315750010106 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 315750010107 intersubunit interface [polypeptide binding]; other site 315750010108 Helix-turn-helix domains; Region: HTH; cl00088 315750010109 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 315750010110 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 315750010111 putative metal binding site [ion binding]; other site 315750010112 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 315750010113 active site 315750010114 metal binding site [ion binding]; metal-binding site 315750010115 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 315750010116 dimerization interface [polypeptide binding]; other site 315750010117 active site 315750010118 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 315750010119 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 315750010120 catalytic motif [active] 315750010121 Zn binding site [ion binding]; other site 315750010122 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 315750010123 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 315750010124 putative active site [active] 315750010125 putative metal binding site [ion binding]; other site 315750010126 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 315750010127 methionine cluster; other site 315750010128 active site 315750010129 phosphorylation site [posttranslational modification] 315750010130 metal binding site [ion binding]; metal-binding site 315750010131 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 315750010132 active site 315750010133 P-loop; other site 315750010134 phosphorylation site [posttranslational modification] 315750010135 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 315750010136 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 315750010137 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 315750010138 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 315750010139 Helix-turn-helix domains; Region: HTH; cl00088 315750010140 Helix-turn-helix domains; Region: HTH; cl00088 315750010141 PRD domain; Region: PRD; cl15445 315750010142 PRD domain; Region: PRD; cl15445 315750010143 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 315750010144 active site 315750010145 P-loop; other site 315750010146 phosphorylation site [posttranslational modification] 315750010147 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 315750010148 active site 315750010149 phosphorylation site [posttranslational modification] 315750010150 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 315750010151 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 315750010152 aspartate ammonia-lyase; Provisional; Region: PRK13353 315750010153 Aspartase; Region: Aspartase; cd01357 315750010154 active sites [active] 315750010155 tetramer interface [polypeptide binding]; other site 315750010156 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 315750010157 active site 315750010158 homodimer interface [polypeptide binding]; other site 315750010159 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315750010160 sequence-specific DNA binding site [nucleotide binding]; other site 315750010161 salt bridge; other site 315750010162 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 315750010163 Proteins of 100 residues with WXG; Region: WXG100; cl02005 315750010164 peptidase T; Region: peptidase-T; TIGR01882 315750010165 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 315750010166 metal binding site [ion binding]; metal-binding site 315750010167 dimer interface [polypeptide binding]; other site 315750010168 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 315750010169 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 315750010170 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 315750010171 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 315750010172 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 315750010173 putative active site [active] 315750010174 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 315750010175 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750010176 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 315750010177 GntP family permease; Region: GntP_permease; pfam02447 315750010178 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 315750010179 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 315750010180 substrate binding site [chemical binding]; other site 315750010181 THF binding site; other site 315750010182 zinc-binding site [ion binding]; other site 315750010183 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315750010184 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750010185 Walker A/P-loop; other site 315750010186 ATP binding site [chemical binding]; other site 315750010187 Q-loop/lid; other site 315750010188 ABC transporter signature motif; other site 315750010189 Walker B; other site 315750010190 D-loop; other site 315750010191 H-loop/switch region; other site 315750010192 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 315750010193 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 315750010194 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 315750010195 active site turn [active] 315750010196 phosphorylation site [posttranslational modification] 315750010197 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 315750010198 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 315750010199 HPr interaction site; other site 315750010200 glycerol kinase (GK) interaction site [polypeptide binding]; other site 315750010201 active site 315750010202 phosphorylation site [posttranslational modification] 315750010203 transcriptional antiterminator BglG; Provisional; Region: PRK09772 315750010204 CAT RNA binding domain; Region: CAT_RBD; cl03904 315750010205 PRD domain; Region: PRD; cl15445 315750010206 PRD domain; Region: PRD; cl15445 315750010207 Transposase domain (DUF772); Region: DUF772; pfam05598 315750010208 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 315750010209 DDE superfamily endonuclease; Region: DDE_4; cl15789 315750010210 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 315750010211 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750010212 dimer interface [polypeptide binding]; other site 315750010213 putative CheW interface [polypeptide binding]; other site 315750010214 Cobalt transport protein; Region: CbiQ; cl00463 315750010215 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 315750010216 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 315750010217 Walker A/P-loop; other site 315750010218 ATP binding site [chemical binding]; other site 315750010219 Q-loop/lid; other site 315750010220 ABC transporter signature motif; other site 315750010221 Walker B; other site 315750010222 D-loop; other site 315750010223 H-loop/switch region; other site 315750010224 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 315750010225 Walker A/P-loop; other site 315750010226 ATP binding site [chemical binding]; other site 315750010227 Q-loop/lid; other site 315750010228 ABC transporter signature motif; other site 315750010229 Walker B; other site 315750010230 D-loop; other site 315750010231 H-loop/switch region; other site 315750010232 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 315750010233 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 315750010234 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 315750010235 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 315750010236 potential catalytic triad [active] 315750010237 conserved cys residue [active] 315750010238 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 315750010239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 315750010240 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 315750010241 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 315750010242 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 315750010243 dimer interface [polypeptide binding]; other site 315750010244 FMN binding site [chemical binding]; other site 315750010245 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315750010246 Helix-turn-helix domains; Region: HTH; cl00088 315750010247 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 315750010248 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 315750010249 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 315750010250 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 315750010251 nucleoside transporter; Region: nupC; TIGR00804 315750010252 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 315750010253 Nucleoside recognition; Region: Gate; cl00486 315750010254 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 315750010255 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 315750010256 intersubunit interface [polypeptide binding]; other site 315750010257 active site 315750010258 catalytic residue [active] 315750010259 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 315750010260 Helix-turn-helix domains; Region: HTH; cl00088 315750010261 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 315750010262 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 315750010263 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 315750010264 active site 315750010265 catalytic residues [active] 315750010266 OpgC protein; Region: OpgC_C; cl00792 315750010267 Acyltransferase family; Region: Acyl_transf_3; pfam01757 315750010268 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 315750010269 catalytic triad [active] 315750010270 catalytic triad [active] 315750010271 oxyanion hole [active] 315750010272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750010273 putative substrate translocation pore; other site 315750010274 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 315750010275 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 315750010276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315750010277 S-adenosylmethionine binding site [chemical binding]; other site 315750010278 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 315750010279 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 315750010280 DNA binding residues [nucleotide binding] 315750010281 dimerization interface [polypeptide binding]; other site 315750010282 sugar phosphate phosphatase; Provisional; Region: PRK10513 315750010283 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750010284 active site 315750010285 motif I; other site 315750010286 motif II; other site 315750010287 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315750010288 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315750010289 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 315750010290 DNA binding residues [nucleotide binding] 315750010291 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 315750010292 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750010293 PAS fold; Region: PAS_3; pfam08447 315750010294 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 315750010295 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315750010296 PAS fold; Region: PAS_3; pfam08447 315750010297 putative active site [active] 315750010298 heme pocket [chemical binding]; other site 315750010299 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315750010300 dimer interface [polypeptide binding]; other site 315750010301 putative CheW interface [polypeptide binding]; other site 315750010302 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 315750010303 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 315750010304 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 315750010305 GntP family permease; Region: GntP_permease; pfam02447 315750010306 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 315750010307 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 315750010308 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 315750010309 N- and C-terminal domain interface [polypeptide binding]; other site 315750010310 putative active site [active] 315750010311 catalytic site [active] 315750010312 metal binding site [ion binding]; metal-binding site 315750010313 carbohydrate binding site [chemical binding]; other site 315750010314 ATP binding site [chemical binding]; other site 315750010315 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 315750010316 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 315750010317 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 315750010318 putative active site [active] 315750010319 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 315750010320 active site 315750010321 tetramer interface [polypeptide binding]; other site 315750010322 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 315750010323 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 315750010324 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 315750010325 Helix-turn-helix domains; Region: HTH; cl00088 315750010326 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 315750010327 putative dimerization interface [polypeptide binding]; other site 315750010328 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 315750010329 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315750010330 DNA binding site [nucleotide binding] 315750010331 domain linker motif; other site 315750010332 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 315750010333 putative dimerization interface [polypeptide binding]; other site 315750010334 putative ligand binding site [chemical binding]; other site 315750010335 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 315750010336 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 315750010337 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 315750010338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750010339 dimer interface [polypeptide binding]; other site 315750010340 conserved gate region; other site 315750010341 putative PBP binding loops; other site 315750010342 ABC-ATPase subunit interface; other site 315750010343 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 315750010344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750010345 dimer interface [polypeptide binding]; other site 315750010346 conserved gate region; other site 315750010347 putative PBP binding loops; other site 315750010348 ABC-ATPase subunit interface; other site 315750010349 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 315750010350 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 315750010351 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 315750010352 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 315750010353 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 315750010354 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 315750010355 Citrate transporter; Region: CitMHS; pfam03600 315750010356 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 315750010357 ABC-2 type transporter; Region: ABC2_membrane; cl11417 315750010358 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315750010359 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 315750010360 Walker A/P-loop; other site 315750010361 ATP binding site [chemical binding]; other site 315750010362 Q-loop/lid; other site 315750010363 ABC transporter signature motif; other site 315750010364 Walker B; other site 315750010365 D-loop; other site 315750010366 H-loop/switch region; other site 315750010367 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315750010368 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750010369 Walker A/P-loop; other site 315750010370 ATP binding site [chemical binding]; other site 315750010371 Q-loop/lid; other site 315750010372 ABC transporter signature motif; other site 315750010373 Walker B; other site 315750010374 D-loop; other site 315750010375 H-loop/switch region; other site 315750010376 LytTr DNA-binding domain; Region: LytTR; cl04498 315750010377 hypothetical protein; Provisional; Region: PRK10220 315750010378 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 315750010379 PhnA protein; Region: PhnA; pfam03831 315750010380 Glycerate kinase family; Region: Gly_kinase; cl00841 315750010381 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 315750010382 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 315750010383 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 315750010384 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 315750010385 Helix-turn-helix domains; Region: HTH; cl00088 315750010386 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750010387 Helix-turn-helix domains; Region: HTH; cl00088 315750010388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750010389 H+ Antiporter protein; Region: 2A0121; TIGR00900 315750010390 putative substrate translocation pore; other site 315750010391 FtsX-like permease family; Region: FtsX; cl15850 315750010392 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315750010393 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 315750010394 Walker A/P-loop; other site 315750010395 ATP binding site [chemical binding]; other site 315750010396 Q-loop/lid; other site 315750010397 ABC transporter signature motif; other site 315750010398 Walker B; other site 315750010399 D-loop; other site 315750010400 H-loop/switch region; other site 315750010401 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315750010402 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 315750010403 transcriptional antiterminator BglG; Provisional; Region: PRK09772 315750010404 CAT RNA binding domain; Region: CAT_RBD; cl03904 315750010405 PRD domain; Region: PRD; cl15445 315750010406 PRD domain; Region: PRD; cl15445 315750010407 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 315750010408 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 315750010409 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 315750010410 active site turn [active] 315750010411 phosphorylation site [posttranslational modification] 315750010412 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 315750010413 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 315750010414 HPr interaction site; other site 315750010415 glycerol kinase (GK) interaction site [polypeptide binding]; other site 315750010416 active site 315750010417 phosphorylation site [posttranslational modification] 315750010418 Helix-turn-helix domains; Region: HTH; cl00088 315750010419 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 315750010420 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 315750010421 putative active site [active] 315750010422 putative CoA binding site [chemical binding]; other site 315750010423 nudix motif; other site 315750010424 metal binding site [ion binding]; metal-binding site 315750010425 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315750010426 non-specific DNA binding site [nucleotide binding]; other site 315750010427 salt bridge; other site 315750010428 sequence-specific DNA binding site [nucleotide binding]; other site 315750010429 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 315750010430 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 315750010431 Transcriptional regulators [Transcription]; Region: PurR; COG1609 315750010432 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315750010433 DNA binding site [nucleotide binding] 315750010434 domain linker motif; other site 315750010435 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 315750010436 putative dimerization interface [polypeptide binding]; other site 315750010437 putative ligand binding site [chemical binding]; other site 315750010438 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315750010439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750010440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750010441 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 315750010442 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 315750010443 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 315750010444 shikimate binding site; other site 315750010445 NAD(P) binding site [chemical binding]; other site 315750010446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750010447 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315750010448 putative substrate translocation pore; other site 315750010449 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 315750010450 putative metal binding site [ion binding]; other site 315750010451 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 315750010452 putative metal binding site [ion binding]; other site 315750010453 Uncharacterized conserved protein [Function unknown]; Region: COG4127 315750010454 Restriction endonuclease; Region: Mrr_cat; cl00516 315750010455 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 315750010456 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 315750010457 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315750010458 DNA-binding site [nucleotide binding]; DNA binding site 315750010459 UTRA domain; Region: UTRA; cl01230 315750010460 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 315750010461 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 315750010462 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315750010463 Helix-turn-helix domains; Region: HTH; cl00088 315750010464 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315750010465 dimerization interface [polypeptide binding]; other site 315750010466 Scramblase; Region: Scramblase; cl02043 315750010467 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 315750010468 ligand binding site [chemical binding]; other site 315750010469 flexible hinge region; other site 315750010470 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315750010471 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315750010472 ATP binding site [chemical binding]; other site 315750010473 putative Mg++ binding site [ion binding]; other site 315750010474 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750010475 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 315750010476 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 315750010477 Cobalt transport protein; Region: CbiQ; cl00463 315750010478 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 315750010479 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 315750010480 Walker A/P-loop; other site 315750010481 ATP binding site [chemical binding]; other site 315750010482 Q-loop/lid; other site 315750010483 ABC transporter signature motif; other site 315750010484 Walker B; other site 315750010485 D-loop; other site 315750010486 H-loop/switch region; other site 315750010487 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 315750010488 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 315750010489 Walker A/P-loop; other site 315750010490 ATP binding site [chemical binding]; other site 315750010491 Q-loop/lid; other site 315750010492 ABC transporter signature motif; other site 315750010493 Walker B; other site 315750010494 D-loop; other site 315750010495 H-loop/switch region; other site 315750010496 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 315750010497 Uncharacterized conserved protein [Function unknown]; Region: COG1912 315750010498 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 315750010499 ABC-2 type transporter; Region: ABC2_membrane; cl11417 315750010500 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750010501 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 315750010502 Walker A/P-loop; other site 315750010503 ATP binding site [chemical binding]; other site 315750010504 Q-loop/lid; other site 315750010505 ABC transporter signature motif; other site 315750010506 Walker B; other site 315750010507 D-loop; other site 315750010508 H-loop/switch region; other site 315750010509 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315750010510 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315750010511 Coenzyme A binding pocket [chemical binding]; other site 315750010512 serine endoprotease; Provisional; Region: PRK10898 315750010513 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 315750010514 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 315750010515 protein binding site [polypeptide binding]; other site 315750010516 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315750010517 YycH protein; Region: YycI; cl02015 315750010518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 315750010519 YycH protein; Region: YycH; pfam07435 315750010520 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 315750010521 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315750010522 dimerization interface [polypeptide binding]; other site 315750010523 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 315750010524 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315750010525 dimer interface [polypeptide binding]; other site 315750010526 phosphorylation site [posttranslational modification] 315750010527 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315750010528 ATP binding site [chemical binding]; other site 315750010529 Mg2+ binding site [ion binding]; other site 315750010530 G-X-G motif; other site 315750010531 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315750010532 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315750010533 active site 315750010534 phosphorylation site [posttranslational modification] 315750010535 intermolecular recognition site; other site 315750010536 dimerization interface [polypeptide binding]; other site 315750010537 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315750010538 DNA binding site [nucleotide binding] 315750010539 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 315750010540 putative catalytic residues [active] 315750010541 Predicted membrane protein [Function unknown]; Region: COG2311 315750010542 Protein of unknown function (DUF418); Region: DUF418; cl12135 315750010543 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 315750010544 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 315750010545 GDP-binding site [chemical binding]; other site 315750010546 ACT binding site; other site 315750010547 IMP binding site; other site 315750010548 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315750010549 Helix-turn-helix domains; Region: HTH; cl00088 315750010550 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 315750010551 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 315750010552 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315750010553 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 315750010554 active site 315750010555 metal binding site [ion binding]; metal-binding site 315750010556 replicative DNA helicase; Provisional; Region: PRK05748 315750010557 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 315750010558 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 315750010559 Walker A motif; other site 315750010560 ATP binding site [chemical binding]; other site 315750010561 Walker B motif; other site 315750010562 DNA binding loops [nucleotide binding] 315750010563 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 315750010564 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315750010565 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 315750010566 intersubunit interface [polypeptide binding]; other site 315750010567 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 315750010568 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 315750010569 putative ligand binding residues [chemical binding]; other site 315750010570 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315750010571 YycC-like protein; Region: YycC; pfam14174 315750010572 cyanate transporter; Region: CynX; TIGR00896 315750010573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315750010574 putative substrate translocation pore; other site 315750010575 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 315750010576 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 315750010577 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 315750010578 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 315750010579 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 315750010580 DHH family; Region: DHH; pfam01368 315750010581 DHHA1 domain; Region: DHHA1; pfam02272 315750010582 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 315750010583 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 315750010584 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 315750010585 DHHA2 domain; Region: DHHA2; pfam02833 315750010586 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 315750010587 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 315750010588 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 315750010589 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315750010590 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315750010591 DNA binding residues [nucleotide binding] 315750010592 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 315750010593 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 315750010594 tetramer interface [polypeptide binding]; other site 315750010595 heme binding pocket [chemical binding]; other site 315750010596 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 315750010597 Predicted esterase [General function prediction only]; Region: COG0400 315750010598 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 315750010599 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315750010600 Zn binding site [ion binding]; other site 315750010601 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 315750010602 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315750010603 Zn binding site [ion binding]; other site 315750010604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315750010605 ABC-ATPase subunit interface; other site 315750010606 NMT1-like family; Region: NMT1_2; cl15260 315750010607 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 315750010608 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 315750010609 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 315750010610 Walker A/P-loop; other site 315750010611 ATP binding site [chemical binding]; other site 315750010612 Q-loop/lid; other site 315750010613 ABC transporter signature motif; other site 315750010614 Walker B; other site 315750010615 D-loop; other site 315750010616 H-loop/switch region; other site 315750010617 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 315750010618 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 315750010619 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 315750010620 dimer interface [polypeptide binding]; other site 315750010621 ssDNA binding site [nucleotide binding]; other site 315750010622 tetramer (dimer of dimers) interface [polypeptide binding]; other site 315750010623 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 315750010624 GTP-binding protein YchF; Reviewed; Region: PRK09601 315750010625 YchF GTPase; Region: YchF; cd01900 315750010626 G1 box; other site 315750010627 GTP/Mg2+ binding site [chemical binding]; other site 315750010628 Switch I region; other site 315750010629 G2 box; other site 315750010630 Switch II region; other site 315750010631 G3 box; other site 315750010632 G4 box; other site 315750010633 G5 box; other site 315750010634 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 315750010635 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 315750010636 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 315750010637 Uncharacterized membrane protein [Function unknown]; Region: COG3949 315750010638 Spore germination protein; Region: Spore_permease; cl15802 315750010639 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 315750010640 ParB-like partition proteins; Region: parB_part; TIGR00180 315750010641 ParB-like nuclease domain; Region: ParBc; cl02129 315750010642 KorB domain; Region: KorB; pfam08535 315750010643 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 315750010644 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 315750010645 P-loop; other site 315750010646 Magnesium ion binding site [ion binding]; other site 315750010647 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 315750010648 Magnesium ion binding site [ion binding]; other site 315750010649 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315750010650 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 315750010651 ParB-like partition proteins; Region: parB_part; TIGR00180 315750010652 ParB-like nuclease domain; Region: ParBc; cl02129 315750010653 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 315750010654 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 315750010655 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315750010656 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 315750010657 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 315750010658 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 315750010659 trmE is a tRNA modification GTPase; Region: trmE; cd04164 315750010660 G1 box; other site 315750010661 GTP/Mg2+ binding site [chemical binding]; other site 315750010662 Switch I region; other site 315750010663 G2 box; other site 315750010664 Switch II region; other site 315750010665 G3 box; other site 315750010666 G4 box; other site 315750010667 G5 box; other site 315750010668 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 315750010669 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 315750010670 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 315750010671 G-X-X-G motif; other site 315750010672 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 315750010673 RxxxH motif; other site 315750010674 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 315750010675 Ribonuclease P; Region: Ribonuclease_P; cl00457 315750010676 Ribosomal protein L34; Region: Ribosomal_L34; cl00370