-- dump date 20120504_134327 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1052588000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1052588000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1052588000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588000004 Walker A motif; other site 1052588000005 ATP binding site [chemical binding]; other site 1052588000006 Walker B motif; other site 1052588000007 arginine finger; other site 1052588000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1052588000009 DnaA box-binding interface [nucleotide binding]; other site 1052588000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1052588000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1052588000012 putative DNA binding surface [nucleotide binding]; other site 1052588000013 dimer interface [polypeptide binding]; other site 1052588000014 beta-clamp/clamp loader binding surface; other site 1052588000015 beta-clamp/translesion DNA polymerase binding surface; other site 1052588000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1052588000017 recF protein; Region: recf; TIGR00611 1052588000018 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 1052588000019 Walker A/P-loop; other site 1052588000020 ATP binding site [chemical binding]; other site 1052588000021 Q-loop/lid; other site 1052588000022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588000023 ABC transporter signature motif; other site 1052588000024 Walker B; other site 1052588000025 D-loop; other site 1052588000026 H-loop/switch region; other site 1052588000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1052588000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588000029 ATP binding site [chemical binding]; other site 1052588000030 Mg2+ binding site [ion binding]; other site 1052588000031 G-X-G motif; other site 1052588000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1052588000033 anchoring element; other site 1052588000034 dimer interface [polypeptide binding]; other site 1052588000035 ATP binding site [chemical binding]; other site 1052588000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1052588000037 active site 1052588000038 putative metal-binding site [ion binding]; other site 1052588000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1052588000040 DNA gyrase subunit A; Validated; Region: PRK05560 1052588000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 1052588000042 CAP-like domain; other site 1052588000043 active site 1052588000044 primary dimer interface [polypeptide binding]; other site 1052588000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052588000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052588000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052588000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052588000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052588000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052588000051 YaaC-like Protein; Region: YaaC; pfam14175 1052588000052 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1052588000053 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1052588000054 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 1052588000055 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 1052588000056 active site 1052588000057 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1052588000058 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052588000059 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 1052588000060 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1052588000061 active site 1052588000062 multimer interface [polypeptide binding]; other site 1052588000063 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1052588000064 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 1052588000065 predicted active site [active] 1052588000066 catalytic triad [active] 1052588000067 seryl-tRNA synthetase; Provisional; Region: PRK05431 1052588000068 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1052588000069 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 1052588000070 dimer interface [polypeptide binding]; other site 1052588000071 active site 1052588000072 motif 1; other site 1052588000073 motif 2; other site 1052588000074 motif 3; other site 1052588000075 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1052588000076 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1052588000077 Substrate-binding site [chemical binding]; other site 1052588000078 Substrate specificity [chemical binding]; other site 1052588000079 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1052588000080 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1052588000081 Substrate-binding site [chemical binding]; other site 1052588000082 Substrate specificity [chemical binding]; other site 1052588000083 Isochorismatase family; Region: Isochorismatase; pfam00857 1052588000084 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1052588000085 catalytic triad [active] 1052588000086 conserved cis-peptide bond; other site 1052588000087 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1052588000088 nucleoside/Zn binding site; other site 1052588000089 dimer interface [polypeptide binding]; other site 1052588000090 catalytic motif [active] 1052588000091 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1052588000092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588000093 Walker A motif; other site 1052588000094 ATP binding site [chemical binding]; other site 1052588000095 Walker B motif; other site 1052588000096 arginine finger; other site 1052588000097 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1052588000098 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 1052588000099 recombination protein RecR; Reviewed; Region: recR; PRK00076 1052588000100 RecR protein; Region: RecR; pfam02132 1052588000101 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1052588000102 putative active site [active] 1052588000103 putative metal-binding site [ion binding]; other site 1052588000104 tetramer interface [polypeptide binding]; other site 1052588000105 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1052588000106 SigmaK-factor processing regulatory protein BofA; Region: BofA; cl06466 1052588000107 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 1052588000108 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 1052588000109 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1052588000110 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1052588000111 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1052588000112 homodimer interface [polypeptide binding]; other site 1052588000113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588000114 catalytic residue [active] 1052588000115 thymidylate kinase; Validated; Region: tmk; PRK00698 1052588000116 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1052588000117 TMP-binding site; other site 1052588000118 ATP-binding site [chemical binding]; other site 1052588000119 Nitrogen regulatory protein P-II; Region: P-II; cl00412 1052588000120 Protein of unknown function (DUF327); Region: DUF327; cl00753 1052588000121 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1052588000122 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588000123 PSP1 C-terminal conserved region; Region: PSP1; cl00770 1052588000124 TSC-22/dip/bun family; Region: TSC22; cl01853 1052588000125 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1052588000126 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1052588000127 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1052588000128 GIY-YIG motif/motif A; other site 1052588000129 putative active site [active] 1052588000130 putative metal binding site [ion binding]; other site 1052588000131 Predicted methyltransferases [General function prediction only]; Region: COG0313 1052588000132 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1052588000133 stage V sporulation protein T; Region: spore_V_T; TIGR02851 1052588000134 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1052588000135 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1052588000136 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1052588000137 active site 1052588000138 HIGH motif; other site 1052588000139 KMSKS motif; other site 1052588000140 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1052588000141 tRNA binding surface [nucleotide binding]; other site 1052588000142 anticodon binding site; other site 1052588000143 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1052588000144 dimer interface [polypeptide binding]; other site 1052588000145 putative tRNA-binding site [nucleotide binding]; other site 1052588000146 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1052588000147 active site 1052588000148 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1052588000149 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1052588000150 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1052588000151 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1052588000152 G5 domain; Region: G5; pfam07501 1052588000153 3D domain; Region: 3D; cl01439 1052588000154 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1052588000155 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1052588000156 putative active site [active] 1052588000157 putative metal binding site [ion binding]; other site 1052588000158 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1052588000159 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588000160 S-adenosylmethionine binding site [chemical binding]; other site 1052588000161 YabG peptidase U57; Region: Peptidase_U57; cl05250 1052588000162 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 1052588000163 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1052588000164 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1052588000165 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1052588000166 pur operon repressor, Bacillus subtilis type; Region: purR_Bsub; TIGR01743 1052588000167 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1052588000168 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052588000169 active site 1052588000170 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1052588000171 homotrimer interaction site [polypeptide binding]; other site 1052588000172 putative active site [active] 1052588000173 SpoVG; Region: SpoVG; cl00915 1052588000174 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1052588000175 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1052588000176 Substrate binding site; other site 1052588000177 Mg++ binding site; other site 1052588000178 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1052588000179 active site 1052588000180 substrate binding site [chemical binding]; other site 1052588000181 CoA binding site [chemical binding]; other site 1052588000182 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1052588000183 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1052588000184 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052588000185 active site 1052588000186 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1052588000187 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1052588000188 5S rRNA interface [nucleotide binding]; other site 1052588000189 CTC domain interface [polypeptide binding]; other site 1052588000190 L16 interface [polypeptide binding]; other site 1052588000191 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1052588000192 putative active site [active] 1052588000193 catalytic residue [active] 1052588000194 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 1052588000195 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588000196 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1052588000197 TRCF domain; Region: TRCF; cl04088 1052588000198 stage V sporulation protein T; Region: spore_V_T; TIGR02851 1052588000199 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1052588000200 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1052588000201 MatE; Region: MatE; cl10513 1052588000202 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 1052588000203 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1052588000204 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1052588000205 homodimer interface [polypeptide binding]; other site 1052588000206 metal binding site [ion binding]; metal-binding site 1052588000207 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs'; Region: NTP-PPase_MazG_Cterm; cd11529 1052588000208 homodimer interface [polypeptide binding]; other site 1052588000209 active site 1052588000210 putative chemical substrate binding site [chemical binding]; other site 1052588000211 metal binding site [ion binding]; metal-binding site 1052588000212 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052588000213 RNA binding surface [nucleotide binding]; other site 1052588000214 YabP family; Region: YabP; cl06766 1052588000215 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 1052588000216 hypothetical protein; Provisional; Region: PRK08582 1052588000217 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 1052588000218 RNA binding site [nucleotide binding]; other site 1052588000219 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1052588000220 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1052588000221 metal ion-dependent adhesion site (MIDAS); other site 1052588000222 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052588000223 active site 1052588000224 ATP binding site [chemical binding]; other site 1052588000225 substrate binding site [chemical binding]; other site 1052588000226 activation loop (A-loop); other site 1052588000227 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1052588000228 Ligand Binding Site [chemical binding]; other site 1052588000229 B3/4 domain; Region: B3_4; cl11458 1052588000230 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052588000231 active site 1052588000232 FtsH Extracellular; Region: FtsH_ext; pfam06480 1052588000233 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1052588000234 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588000235 Walker A motif; other site 1052588000236 ATP binding site [chemical binding]; other site 1052588000237 Walker B motif; other site 1052588000238 arginine finger; other site 1052588000239 Peptidase family M41; Region: Peptidase_M41; pfam01434 1052588000240 Type III pantothenate kinase; Region: Pan_kinase; cl09130 1052588000241 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1052588000242 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1052588000243 dimerization interface [polypeptide binding]; other site 1052588000244 domain crossover interface; other site 1052588000245 redox-dependent activation switch; other site 1052588000246 SurA N-terminal domain; Region: SurA_N_3; cl07813 1052588000247 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1052588000248 PPIC-type PPIASE domain; Region: Rotamase; cl08278 1052588000249 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1052588000250 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1052588000251 dimer interface [polypeptide binding]; other site 1052588000252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588000253 catalytic residue [active] 1052588000254 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1052588000255 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1052588000256 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1052588000257 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1052588000258 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1052588000259 glutamine binding [chemical binding]; other site 1052588000260 catalytic triad [active] 1052588000261 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1052588000262 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588000263 catalytic residue [active] 1052588000264 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1052588000265 dihydropteroate synthase; Region: DHPS; TIGR01496 1052588000266 substrate binding pocket [chemical binding]; other site 1052588000267 dimer interface [polypeptide binding]; other site 1052588000268 inhibitor binding site; inhibition site 1052588000269 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1052588000270 homooctamer interface [polypeptide binding]; other site 1052588000271 active site 1052588000272 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1052588000273 catalytic center binding site [active] 1052588000274 ATP binding site [chemical binding]; other site 1052588000275 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052588000276 non-specific DNA binding site [nucleotide binding]; other site 1052588000277 salt bridge; other site 1052588000278 sequence-specific DNA binding site [nucleotide binding]; other site 1052588000279 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1052588000280 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1052588000281 FMN binding site [chemical binding]; other site 1052588000282 active site 1052588000283 catalytic residues [active] 1052588000284 substrate binding site [chemical binding]; other site 1052588000285 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1052588000286 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1052588000287 dimer interface [polypeptide binding]; other site 1052588000288 putative anticodon binding site; other site 1052588000289 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1052588000290 motif 1; other site 1052588000291 active site 1052588000292 motif 2; other site 1052588000293 motif 3; other site 1052588000294 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 1052588000295 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1052588000296 UvrB/uvrC motif; Region: UVR; pfam02151 1052588000297 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 1052588000298 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1052588000299 ADP binding site [chemical binding]; other site 1052588000300 phosphagen binding site; other site 1052588000301 substrate specificity loop; other site 1052588000302 Clp protease ATP binding subunit; Region: clpC; CHL00095 1052588000303 Clp amino terminal domain; Region: Clp_N; pfam02861 1052588000304 Clp amino terminal domain; Region: Clp_N; pfam02861 1052588000305 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588000306 Walker A motif; other site 1052588000307 ATP binding site [chemical binding]; other site 1052588000308 Walker B motif; other site 1052588000309 arginine finger; other site 1052588000310 UvrB/uvrC motif; Region: UVR; pfam02151 1052588000311 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588000312 Walker A motif; other site 1052588000313 ATP binding site [chemical binding]; other site 1052588000314 Walker B motif; other site 1052588000315 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1052588000316 DNA repair protein RadA; Provisional; Region: PRK11823 1052588000317 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1052588000318 Walker A motif/ATP binding site; other site 1052588000319 ATP binding site [chemical binding]; other site 1052588000320 Walker B motif; other site 1052588000321 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1052588000322 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1052588000323 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1052588000324 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1052588000325 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1052588000326 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1052588000327 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1052588000328 putative active site [active] 1052588000329 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1052588000330 substrate binding site; other site 1052588000331 dimer interface; other site 1052588000332 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1052588000333 homotrimer interaction site [polypeptide binding]; other site 1052588000334 zinc binding site [ion binding]; other site 1052588000335 CDP-binding sites; other site 1052588000336 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1052588000337 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1052588000338 active site 1052588000339 HIGH motif; other site 1052588000340 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1052588000341 active site 1052588000342 KMSKS motif; other site 1052588000343 serine O-acetyltransferase; Region: cysE; TIGR01172 1052588000344 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1052588000345 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1052588000346 trimer interface [polypeptide binding]; other site 1052588000347 active site 1052588000348 substrate binding site [chemical binding]; other site 1052588000349 CoA binding site [chemical binding]; other site 1052588000350 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1052588000351 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1052588000352 active site 1052588000353 HIGH motif; other site 1052588000354 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1052588000355 KMSKS motif; other site 1052588000356 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1052588000357 tRNA binding surface [nucleotide binding]; other site 1052588000358 anticodon binding site; other site 1052588000359 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1052588000360 active site 1052588000361 metal binding site [ion binding]; metal-binding site 1052588000362 dimerization interface [polypeptide binding]; other site 1052588000363 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1052588000364 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 1052588000365 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1052588000366 YacP-like NYN domain; Region: NYN_YacP; cl01491 1052588000367 RNA polymerase factor sigma-70; Validated; Region: PRK08295 1052588000368 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052588000369 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1052588000370 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 1052588000371 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1052588000372 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1052588000373 putative homodimer interface [polypeptide binding]; other site 1052588000374 KOW motif; Region: KOW; cl00354 1052588000375 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1052588000376 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1052588000377 23S rRNA interface [nucleotide binding]; other site 1052588000378 L7/L12 interface [polypeptide binding]; other site 1052588000379 putative thiostrepton binding site; other site 1052588000380 L25 interface [polypeptide binding]; other site 1052588000381 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1052588000382 mRNA/rRNA interface [nucleotide binding]; other site 1052588000383 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1052588000384 23S rRNA interface [nucleotide binding]; other site 1052588000385 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1052588000386 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1052588000387 core dimer interface [polypeptide binding]; other site 1052588000388 peripheral dimer interface [polypeptide binding]; other site 1052588000389 L10 interface [polypeptide binding]; other site 1052588000390 L11 interface [polypeptide binding]; other site 1052588000391 putative EF-Tu interaction site [polypeptide binding]; other site 1052588000392 putative EF-G interaction site [polypeptide binding]; other site 1052588000393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588000394 S-adenosylmethionine binding site [chemical binding]; other site 1052588000395 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1052588000396 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 1052588000397 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1052588000398 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1052588000399 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1052588000400 RPB1 interaction site [polypeptide binding]; other site 1052588000401 RPB10 interaction site [polypeptide binding]; other site 1052588000402 RPB11 interaction site [polypeptide binding]; other site 1052588000403 RPB3 interaction site [polypeptide binding]; other site 1052588000404 RPB12 interaction site [polypeptide binding]; other site 1052588000405 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1052588000406 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1052588000407 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 1052588000408 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1052588000409 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1052588000410 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1052588000411 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1052588000412 G-loop; other site 1052588000413 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1052588000414 DNA binding site [nucleotide binding] 1052588000415 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1052588000416 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1052588000417 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 1052588000418 elongation factor G; Reviewed; Region: PRK00007 1052588000419 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1052588000420 Switch I region; other site 1052588000421 G2 box; other site 1052588000422 putative GEF interaction site [polypeptide binding]; other site 1052588000423 G3 box; other site 1052588000424 Switch II region; other site 1052588000425 GTP/Mg2+ binding site [chemical binding]; other site 1052588000426 G4 box; other site 1052588000427 G5 box; other site 1052588000428 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1052588000429 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1052588000430 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1052588000431 elongation factor Tu; Reviewed; Region: PRK00049 1052588000432 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1052588000433 G1 box; other site 1052588000434 GEF interaction site [polypeptide binding]; other site 1052588000435 GTP/Mg2+ binding site [chemical binding]; other site 1052588000436 Switch I region; other site 1052588000437 G2 box; other site 1052588000438 G3 box; other site 1052588000439 Switch II region; other site 1052588000440 G4 box; other site 1052588000441 G5 box; other site 1052588000442 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1052588000443 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1052588000444 Antibiotic Binding Site [chemical binding]; other site 1052588000445 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052588000446 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 1052588000447 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 1052588000448 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1052588000449 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 1052588000450 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1052588000451 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1052588000452 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1052588000453 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1052588000454 putative translocon binding site; other site 1052588000455 protein-rRNA interface [nucleotide binding]; other site 1052588000456 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1052588000457 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1052588000458 G-X-X-G motif; other site 1052588000459 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1052588000460 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1052588000461 23S rRNA interface [nucleotide binding]; other site 1052588000462 5S rRNA interface [nucleotide binding]; other site 1052588000463 putative antibiotic binding site [chemical binding]; other site 1052588000464 L25 interface [polypeptide binding]; other site 1052588000465 L27 interface [polypeptide binding]; other site 1052588000466 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1052588000467 23S rRNA interface [nucleotide binding]; other site 1052588000468 putative translocon interaction site; other site 1052588000469 signal recognition particle (SRP54) interaction site; other site 1052588000470 L23 interface [polypeptide binding]; other site 1052588000471 trigger factor interaction site; other site 1052588000472 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 1052588000473 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1052588000474 KOW motif; Region: KOW; cl00354 1052588000475 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1052588000476 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1052588000477 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1052588000478 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 1052588000479 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 1052588000480 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1052588000481 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1052588000482 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1052588000483 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1052588000484 5S rRNA interface [nucleotide binding]; other site 1052588000485 L27 interface [polypeptide binding]; other site 1052588000486 23S rRNA interface [nucleotide binding]; other site 1052588000487 L5 interface [polypeptide binding]; other site 1052588000488 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1052588000489 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1052588000490 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1052588000491 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1052588000492 23S rRNA binding site [nucleotide binding]; other site 1052588000493 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 1052588000494 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1052588000495 SecY translocase; Region: SecY; pfam00344 1052588000496 adenylate kinase; Reviewed; Region: adk; PRK00279 1052588000497 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1052588000498 AMP-binding site [chemical binding]; other site 1052588000499 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1052588000500 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1052588000501 active site 1052588000502 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 1052588000503 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1052588000504 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 1052588000505 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 1052588000506 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1052588000507 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1052588000508 alphaNTD homodimer interface [polypeptide binding]; other site 1052588000509 alphaNTD - beta interaction site [polypeptide binding]; other site 1052588000510 alphaNTD - beta' interaction site [polypeptide binding]; other site 1052588000511 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 1052588000512 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 1052588000513 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1052588000514 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 1052588000515 Walker A/P-loop; other site 1052588000516 ATP binding site [chemical binding]; other site 1052588000517 Q-loop/lid; other site 1052588000518 ABC transporter signature motif; other site 1052588000519 Walker B; other site 1052588000520 D-loop; other site 1052588000521 H-loop/switch region; other site 1052588000522 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 1052588000523 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 1052588000524 Walker A/P-loop; other site 1052588000525 ATP binding site [chemical binding]; other site 1052588000526 Q-loop/lid; other site 1052588000527 ABC transporter signature motif; other site 1052588000528 Walker B; other site 1052588000529 D-loop; other site 1052588000530 H-loop/switch region; other site 1052588000531 Cobalt transport protein; Region: CbiQ; cl00463 1052588000532 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1052588000533 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1052588000534 dimerization interface 3.5A [polypeptide binding]; other site 1052588000535 active site 1052588000536 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1052588000537 23S rRNA interface [nucleotide binding]; other site 1052588000538 L3 interface [polypeptide binding]; other site 1052588000539 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 1052588000540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588000541 S-adenosylmethionine binding site [chemical binding]; other site 1052588000542 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 1052588000543 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1052588000544 active site 1052588000545 metal binding site [ion binding]; metal-binding site 1052588000546 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1052588000547 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 1052588000548 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 1052588000549 NodB motif; other site 1052588000550 putative active site [active] 1052588000551 putative catalytic site [active] 1052588000552 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1052588000553 Sulfate transporter family; Region: Sulfate_transp; cl15842 1052588000554 Sulfate transporter family; Region: Sulfate_transp; cl15842 1052588000555 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1052588000556 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1052588000557 Membrane transport protein; Region: Mem_trans; cl09117 1052588000558 Membrane transport protein; Region: Mem_trans; cl09117 1052588000559 Putative esterase; Region: Esterase; pfam00756 1052588000560 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052588000561 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1052588000562 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052588000563 dimer interface [polypeptide binding]; other site 1052588000564 putative PBP binding regions; other site 1052588000565 ABC-ATPase subunit interface; other site 1052588000566 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052588000567 ABC-ATPase subunit interface; other site 1052588000568 dimer interface [polypeptide binding]; other site 1052588000569 putative PBP binding regions; other site 1052588000570 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1052588000571 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1052588000572 putative ligand binding residues [chemical binding]; other site 1052588000573 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052588000574 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052588000575 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052588000576 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1052588000577 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1052588000578 putative ligand binding residues [chemical binding]; other site 1052588000579 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 1052588000580 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1052588000581 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1052588000582 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1052588000583 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052588000584 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1052588000585 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1052588000586 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052588000587 active site turn [active] 1052588000588 phosphorylation site [posttranslational modification] 1052588000589 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1052588000590 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1052588000591 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1052588000592 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1052588000593 putative active site [active] 1052588000594 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1052588000595 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1052588000596 putative active site [active] 1052588000597 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1052588000598 Protein of unknown function (DUF523); Region: DUF523; cl00733 1052588000599 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 1052588000600 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052588000601 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588000602 DNA binding residues [nucleotide binding] 1052588000603 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1052588000604 Putative zinc-finger; Region: zf-HC2; cl15806 1052588000605 TIGR00159 family protein; Region: TIGR00159 1052588000606 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1052588000607 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1052588000608 YbbR-like protein; Region: YbbR; pfam07949 1052588000609 YbbR-like protein; Region: YbbR; pfam07949 1052588000610 YbbR-like protein; Region: YbbR; pfam07949 1052588000611 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1052588000612 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1052588000613 active site 1052588000614 substrate binding site [chemical binding]; other site 1052588000615 metal binding site [ion binding]; metal-binding site 1052588000616 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1052588000617 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1052588000618 glutaminase active site [active] 1052588000619 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1052588000620 dimer interface [polypeptide binding]; other site 1052588000621 active site 1052588000622 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1052588000623 dimer interface [polypeptide binding]; other site 1052588000624 active site 1052588000625 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 1052588000626 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 1052588000627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 1052588000628 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1052588000629 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1052588000630 zinc binding site [ion binding]; other site 1052588000631 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 1052588000632 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052588000633 dimerization interface [polypeptide binding]; other site 1052588000634 putative DNA binding site [nucleotide binding]; other site 1052588000635 putative Zn2+ binding site [ion binding]; other site 1052588000636 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052588000637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588000638 putative substrate translocation pore; other site 1052588000639 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1052588000640 active site 1052588000641 ATP binding site [chemical binding]; other site 1052588000642 substrate binding site [chemical binding]; other site 1052588000643 activation loop (A-loop); other site 1052588000644 putative transport protein YifK; Provisional; Region: PRK10746 1052588000645 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052588000646 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1052588000647 Spore germination protein; Region: Spore_permease; cl15802 1052588000648 amino acid transporter; Region: 2A0306; TIGR00909 1052588000649 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1052588000650 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052588000651 active site 1052588000652 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1052588000653 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1052588000654 active site 1052588000655 catalytic site [active] 1052588000656 metal binding site [ion binding]; metal-binding site 1052588000657 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 1052588000658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588000659 putative substrate translocation pore; other site 1052588000660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588000661 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 1052588000662 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588000663 Helix-turn-helix domains; Region: HTH; cl00088 1052588000664 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052588000665 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588000666 Coenzyme A binding pocket [chemical binding]; other site 1052588000667 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588000668 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588000669 putative substrate translocation pore; other site 1052588000670 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1052588000671 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1052588000672 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1052588000673 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 1052588000674 active site 1052588000675 EamA-like transporter family; Region: EamA; cl01037 1052588000676 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1052588000677 EamA-like transporter family; Region: EamA; cl01037 1052588000678 Cupin domain; Region: Cupin_2; cl09118 1052588000679 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052588000680 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052588000681 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052588000682 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1052588000683 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052588000684 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1052588000685 alanyl-tRNA synthetase; Provisional; Region: PRK01584 1052588000686 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1052588000687 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 1052588000688 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052588000689 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052588000690 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1052588000691 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1052588000692 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 1052588000693 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 1052588000694 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1052588000695 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1052588000696 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1052588000697 active site residue [active] 1052588000698 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1052588000699 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1052588000700 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1052588000701 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1052588000702 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1052588000703 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052588000704 active site turn [active] 1052588000705 phosphorylation site [posttranslational modification] 1052588000706 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1052588000707 HPr interaction site; other site 1052588000708 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1052588000709 active site 1052588000710 phosphorylation site [posttranslational modification] 1052588000711 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1052588000712 active site 1052588000713 trimer interface [polypeptide binding]; other site 1052588000714 allosteric site; other site 1052588000715 active site lid [active] 1052588000716 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1052588000717 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1052588000718 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588000719 DNA-binding site [nucleotide binding]; DNA binding site 1052588000720 UTRA domain; Region: UTRA; cl01230 1052588000721 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1052588000722 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1052588000723 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1052588000724 homodimer interface [polypeptide binding]; other site 1052588000725 substrate-cofactor binding pocket; other site 1052588000726 catalytic residue [active] 1052588000727 S-methylmethionine transporter; Provisional; Region: PRK11387 1052588000728 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1052588000729 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1052588000730 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1052588000731 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1052588000732 Glutaminase; Region: Glutaminase; cl00907 1052588000733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588000734 Response regulator receiver domain; Region: Response_reg; pfam00072 1052588000735 active site 1052588000736 phosphorylation site [posttranslational modification] 1052588000737 intermolecular recognition site; other site 1052588000738 dimerization interface [polypeptide binding]; other site 1052588000739 YcbB domain; Region: YcbB; pfam08664 1052588000740 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 1052588000741 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1052588000742 putative active site [active] 1052588000743 catalytic residue [active] 1052588000744 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 1052588000745 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1052588000746 NAD(P) binding site [chemical binding]; other site 1052588000747 catalytic residues [active] 1052588000748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588000749 D-galactonate transporter; Region: 2A0114; TIGR00893 1052588000750 putative substrate translocation pore; other site 1052588000751 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1052588000752 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1052588000753 active site 1052588000754 tetramer interface [polypeptide binding]; other site 1052588000755 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1052588000756 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588000757 DNA-binding site [nucleotide binding]; DNA binding site 1052588000758 FCD domain; Region: FCD; cl11656 1052588000759 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1052588000760 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1052588000761 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1052588000762 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 1052588000763 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: MPH2'; cd05152 1052588000764 putative active site [active] 1052588000765 putative substrate binding site [chemical binding]; other site 1052588000766 ATP binding site [chemical binding]; other site 1052588000767 anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748 1052588000768 dodecamer interface 1 [polypeptide binding]; other site 1052588000769 dodecamer interface 2 [polypeptide binding]; other site 1052588000770 trimer interface [polypeptide binding]; other site 1052588000771 TRAP binding interface [polypeptide binding]; other site 1052588000772 Zn binding site [ion binding]; other site 1052588000773 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1052588000774 EamA-like transporter family; Region: EamA; cl01037 1052588000775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588000776 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1052588000777 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1052588000778 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1052588000779 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1052588000780 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1052588000781 putative active site [active] 1052588000782 putative metal binding site [ion binding]; other site 1052588000783 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1052588000784 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1052588000785 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 1052588000786 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1052588000787 putative substrate binding pocket [chemical binding]; other site 1052588000788 AC domain interface; other site 1052588000789 catalytic triad [active] 1052588000790 AB domain interface; other site 1052588000791 interchain disulfide; other site 1052588000792 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1052588000793 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1052588000794 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052588000795 catalytic residue [active] 1052588000796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588000797 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588000798 putative substrate translocation pore; other site 1052588000799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588000800 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052588000801 Helix-turn-helix domains; Region: HTH; cl00088 1052588000802 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1052588000803 active site 1052588000804 homotetramer interface [polypeptide binding]; other site 1052588000805 homodimer interface [polypeptide binding]; other site 1052588000806 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1052588000807 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052588000808 RDD family; Region: RDD; cl00746 1052588000809 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 1052588000810 helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225 1052588000811 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1052588000812 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588000813 ATP binding site [chemical binding]; other site 1052588000814 Mg2+ binding site [ion binding]; other site 1052588000815 G-X-G motif; other site 1052588000816 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1052588000817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588000818 active site 1052588000819 phosphorylation site [posttranslational modification] 1052588000820 intermolecular recognition site; other site 1052588000821 dimerization interface [polypeptide binding]; other site 1052588000822 LytTr DNA-binding domain; Region: LytTR; cl04498 1052588000823 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1052588000824 NatA is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled proton or K+ uptake. NatB possess six putative membrane spanning regions at its...; Region: ABC_NatA_sodium_exporter; cd03266 1052588000825 Walker A/P-loop; other site 1052588000826 ATP binding site [chemical binding]; other site 1052588000827 Q-loop/lid; other site 1052588000828 ABC transporter signature motif; other site 1052588000829 Walker B; other site 1052588000830 D-loop; other site 1052588000831 H-loop/switch region; other site 1052588000832 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1052588000833 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1052588000834 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1052588000835 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052588000836 active site 1052588000837 catalytic tetrad [active] 1052588000838 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1052588000839 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1052588000840 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 1052588000841 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 1052588000842 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052588000843 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1052588000844 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1052588000845 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1052588000846 NAD binding site [chemical binding]; other site 1052588000847 homodimer interface [polypeptide binding]; other site 1052588000848 active site 1052588000849 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1052588000850 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1052588000851 Ca binding site [ion binding]; other site 1052588000852 active site 1052588000853 catalytic site [active] 1052588000854 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1052588000855 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1052588000856 metal binding site [ion binding]; metal-binding site 1052588000857 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1052588000858 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 1052588000859 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052588000860 ABC-ATPase subunit interface; other site 1052588000861 dimer interface [polypeptide binding]; other site 1052588000862 putative PBP binding regions; other site 1052588000863 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1052588000864 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1052588000865 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1052588000866 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1052588000867 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1052588000868 putative metal binding site [ion binding]; other site 1052588000869 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1052588000870 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1052588000871 putative metal binding site [ion binding]; other site 1052588000872 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1052588000873 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1052588000874 putative metal binding site [ion binding]; other site 1052588000875 Integral membrane protein TerC family; Region: TerC; cl10468 1052588000876 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 1052588000877 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1052588000878 benzoate transport; Region: 2A0115; TIGR00895 1052588000879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588000880 putative substrate translocation pore; other site 1052588000881 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052588000882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588000883 putative substrate translocation pore; other site 1052588000884 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052588000885 dimerization interface [polypeptide binding]; other site 1052588000886 putative DNA binding site [nucleotide binding]; other site 1052588000887 putative Zn2+ binding site [ion binding]; other site 1052588000888 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 1052588000889 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1052588000890 Walker A/P-loop; other site 1052588000891 ATP binding site [chemical binding]; other site 1052588000892 Q-loop/lid; other site 1052588000893 ABC transporter signature motif; other site 1052588000894 Walker B; other site 1052588000895 D-loop; other site 1052588000896 H-loop/switch region; other site 1052588000897 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1052588000898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588000899 dimer interface [polypeptide binding]; other site 1052588000900 conserved gate region; other site 1052588000901 putative PBP binding loops; other site 1052588000902 ABC-ATPase subunit interface; other site 1052588000903 NMT1-like family; Region: NMT1_2; cl15260 1052588000904 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 1052588000905 amidohydrolase; Region: amidohydrolases; TIGR01891 1052588000906 metal binding site [ion binding]; metal-binding site 1052588000907 putative dimer interface [polypeptide binding]; other site 1052588000908 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 1052588000909 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1052588000910 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 1052588000911 active site 1052588000912 Ca binding site [ion binding]; other site 1052588000913 catalytic site [active] 1052588000914 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 1052588000915 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1052588000916 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1052588000917 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052588000918 NAD binding site [chemical binding]; other site 1052588000919 dimer interface [polypeptide binding]; other site 1052588000920 substrate binding site [chemical binding]; other site 1052588000921 glycolate transporter; Provisional; Region: PRK09695 1052588000922 L-lactate permease; Region: Lactate_perm; cl00701 1052588000923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588000924 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588000925 putative substrate translocation pore; other site 1052588000926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588000927 Helix-turn-helix domains; Region: HTH; cl00088 1052588000928 LysE type translocator; Region: LysE; cl00565 1052588000929 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 1052588000930 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1052588000931 Spore germination protein; Region: Spore_permease; cl15802 1052588000932 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 1052588000933 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1052588000934 NAD+ synthetase; Region: nadE; TIGR00552 1052588000935 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1052588000936 homodimer interface [polypeptide binding]; other site 1052588000937 NAD binding pocket [chemical binding]; other site 1052588000938 ATP binding pocket [chemical binding]; other site 1052588000939 Mg binding site [ion binding]; other site 1052588000940 active-site loop [active] 1052588000941 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588000942 shikimate kinase; Reviewed; Region: aroK; PRK00131 1052588000943 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1052588000944 ADP binding site [chemical binding]; other site 1052588000945 magnesium binding site [ion binding]; other site 1052588000946 putative shikimate binding site; other site 1052588000947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588000948 S-adenosylmethionine binding site [chemical binding]; other site 1052588000949 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052588000950 Helix-turn-helix domains; Region: HTH; cl00088 1052588000951 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052588000952 dimerization interface [polypeptide binding]; other site 1052588000953 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1052588000954 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 1052588000955 Proline dehydrogenase; Region: Pro_dh; cl03282 1052588000956 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1052588000957 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1052588000958 Glutamate binding site [chemical binding]; other site 1052588000959 homodimer interface [polypeptide binding]; other site 1052588000960 NAD binding site [chemical binding]; other site 1052588000961 catalytic residues [active] 1052588000962 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1052588000963 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1052588000964 Na binding site [ion binding]; other site 1052588000965 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1052588000966 Helix-turn-helix domains; Region: HTH; cl00088 1052588000967 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 1052588000968 Predicted permeases [General function prediction only]; Region: COG0701 1052588000969 Predicted permease; Region: DUF318; pfam03773 1052588000970 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1052588000971 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1052588000972 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052588000973 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1052588000974 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 1052588000975 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1052588000976 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1052588000977 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1052588000978 [2Fe-2S] cluster binding site [ion binding]; other site 1052588000979 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1052588000980 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052588000981 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1052588000982 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1052588000983 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1052588000984 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1052588000985 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1052588000986 [4Fe-4S] binding site [ion binding]; other site 1052588000987 molybdopterin cofactor binding site; other site 1052588000988 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1052588000989 molybdopterin cofactor binding site; other site 1052588000990 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1052588000991 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052588000992 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1052588000993 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1052588000994 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1052588000995 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1052588000996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588000997 putative substrate translocation pore; other site 1052588000998 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 1052588000999 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 1052588001000 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1052588001001 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588001002 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 1052588001003 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1052588001004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588001005 dimer interface [polypeptide binding]; other site 1052588001006 conserved gate region; other site 1052588001007 putative PBP binding loops; other site 1052588001008 ABC-ATPase subunit interface; other site 1052588001009 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1052588001010 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1052588001011 substrate binding pocket [chemical binding]; other site 1052588001012 membrane-bound complex binding site; other site 1052588001013 hinge residues; other site 1052588001014 RDD family; Region: RDD; cl00746 1052588001015 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 1052588001016 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588001017 Helix-turn-helix domains; Region: HTH; cl00088 1052588001018 hypothetical protein; Provisional; Region: PRK09272 1052588001019 Predicted ATPase [General function prediction only]; Region: COG3910 1052588001020 ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The...; Region: ABC_ATPase; cd00267 1052588001021 Walker A/P-loop; other site 1052588001022 ATP binding site [chemical binding]; other site 1052588001023 Q-loop/lid; other site 1052588001024 ABC transporter signature motif; other site 1052588001025 Walker B; other site 1052588001026 D-loop; other site 1052588001027 H-loop/switch region; other site 1052588001028 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1052588001029 Competence protein J (ComJ); Region: ComJ; pfam11033 1052588001030 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1052588001031 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1052588001032 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052588001033 dimer interface [polypeptide binding]; other site 1052588001034 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1052588001035 putative CheW interface [polypeptide binding]; other site 1052588001036 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1052588001037 tetramer interface [polypeptide binding]; other site 1052588001038 Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane]; Region: GutQ; COG0794 1052588001039 active site 1052588001040 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1052588001041 active site 1052588001042 dimer interface [polypeptide binding]; other site 1052588001043 magnesium binding site [ion binding]; other site 1052588001044 Helix-turn-helix domains; Region: HTH; cl00088 1052588001045 peptide synthase; Provisional; Region: PRK12467 1052588001046 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588001047 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588001048 peptide synthase; Provisional; Region: PRK12467 1052588001049 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052588001050 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588001051 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588001052 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052588001053 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588001054 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588001055 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052588001056 peptide synthase; Provisional; Region: PRK12467 1052588001057 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588001058 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588001059 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588001060 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1052588001061 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1052588001062 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 1052588001063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588001064 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588001065 putative substrate translocation pore; other site 1052588001066 YcxB-like protein; Region: YcxB; pfam14317 1052588001067 EamA-like transporter family; Region: EamA; cl01037 1052588001068 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1052588001069 EamA-like transporter family; Region: EamA; cl01037 1052588001070 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1052588001071 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588001072 DNA-binding site [nucleotide binding]; DNA binding site 1052588001073 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052588001074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588001075 homodimer interface [polypeptide binding]; other site 1052588001076 catalytic residue [active] 1052588001077 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1052588001078 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1052588001079 Predicted membrane protein [Function unknown]; Region: COG2364 1052588001080 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052588001081 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1052588001082 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1052588001083 Walker A/P-loop; other site 1052588001084 ATP binding site [chemical binding]; other site 1052588001085 Q-loop/lid; other site 1052588001086 ABC transporter signature motif; other site 1052588001087 Walker B; other site 1052588001088 D-loop; other site 1052588001089 H-loop/switch region; other site 1052588001090 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1052588001091 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588001092 dimer interface [polypeptide binding]; other site 1052588001093 conserved gate region; other site 1052588001094 putative PBP binding loops; other site 1052588001095 ABC-ATPase subunit interface; other site 1052588001096 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1052588001097 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1052588001098 substrate binding pocket [chemical binding]; other site 1052588001099 membrane-bound complex binding site; other site 1052588001100 hinge residues; other site 1052588001101 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052588001102 Helix-turn-helix domains; Region: HTH; cl00088 1052588001103 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052588001104 dimerization interface [polypeptide binding]; other site 1052588001105 polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases; Region: ubiX_pad; TIGR00421 1052588001106 Flavoprotein; Region: Flavoprotein; cl08021 1052588001107 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 1052588001108 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1052588001109 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1052588001110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588001111 putative substrate translocation pore; other site 1052588001112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 1052588001113 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1052588001114 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1052588001115 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1052588001116 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 1052588001117 Spore germination protein; Region: Spore_permease; cl15802 1052588001118 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052588001119 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1052588001120 Walker A/P-loop; other site 1052588001121 ATP binding site [chemical binding]; other site 1052588001122 Q-loop/lid; other site 1052588001123 ABC transporter signature motif; other site 1052588001124 Walker B; other site 1052588001125 D-loop; other site 1052588001126 H-loop/switch region; other site 1052588001127 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1052588001128 FtsX-like permease family; Region: FtsX; cl15850 1052588001129 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052588001130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588001131 active site 1052588001132 phosphorylation site [posttranslational modification] 1052588001133 intermolecular recognition site; other site 1052588001134 dimerization interface [polypeptide binding]; other site 1052588001135 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052588001136 DNA binding site [nucleotide binding] 1052588001137 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052588001138 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052588001139 dimerization interface [polypeptide binding]; other site 1052588001140 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052588001141 dimer interface [polypeptide binding]; other site 1052588001142 phosphorylation site [posttranslational modification] 1052588001143 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588001144 ATP binding site [chemical binding]; other site 1052588001145 Mg2+ binding site [ion binding]; other site 1052588001146 G-X-G motif; other site 1052588001147 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052588001148 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052588001149 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1052588001150 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 1052588001151 aspartate kinase; Reviewed; Region: PRK09034 1052588001152 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1052588001153 putative catalytic residues [active] 1052588001154 putative nucleotide binding site [chemical binding]; other site 1052588001155 putative aspartate binding site [chemical binding]; other site 1052588001156 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1052588001157 allosteric regulatory residue; other site 1052588001158 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1052588001159 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1052588001160 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052588001161 ABC-ATPase subunit interface; other site 1052588001162 dimer interface [polypeptide binding]; other site 1052588001163 putative PBP binding regions; other site 1052588001164 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052588001165 ABC-ATPase subunit interface; other site 1052588001166 dimer interface [polypeptide binding]; other site 1052588001167 putative PBP binding regions; other site 1052588001168 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1052588001169 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1052588001170 Walker A/P-loop; other site 1052588001171 ATP binding site [chemical binding]; other site 1052588001172 Q-loop/lid; other site 1052588001173 ABC transporter signature motif; other site 1052588001174 Walker B; other site 1052588001175 D-loop; other site 1052588001176 H-loop/switch region; other site 1052588001177 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1052588001178 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1052588001179 putative ligand binding residues [chemical binding]; other site 1052588001180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588001181 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588001182 putative substrate translocation pore; other site 1052588001183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588001184 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052588001185 Helix-turn-helix domains; Region: HTH; cl00088 1052588001186 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1052588001187 dimer interface [polypeptide binding]; other site 1052588001188 FMN binding site [chemical binding]; other site 1052588001189 NADPH bind site [chemical binding]; other site 1052588001190 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1052588001191 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052588001192 dimerization interface [polypeptide binding]; other site 1052588001193 putative DNA binding site [nucleotide binding]; other site 1052588001194 putative Zn2+ binding site [ion binding]; other site 1052588001195 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1052588001196 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588001197 DNA-binding site [nucleotide binding]; DNA binding site 1052588001198 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052588001199 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588001200 homodimer interface [polypeptide binding]; other site 1052588001201 catalytic residue [active] 1052588001202 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 1052588001203 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052588001204 inhibitor-cofactor binding pocket; inhibition site 1052588001205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588001206 catalytic residue [active] 1052588001207 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1052588001208 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1052588001209 tetramerization interface [polypeptide binding]; other site 1052588001210 NAD(P) binding site [chemical binding]; other site 1052588001211 catalytic residues [active] 1052588001212 Sugar transport protein; Region: Sugar_transport; pfam06800 1052588001213 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1052588001214 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1052588001215 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1052588001216 NAD binding site [chemical binding]; other site 1052588001217 homodimer interface [polypeptide binding]; other site 1052588001218 active site 1052588001219 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1052588001220 Bacterial Ig-like domain; Region: Big_5; cl01012 1052588001221 Copper resistance protein D; Region: CopD; cl00563 1052588001222 FixH; Region: FixH; cl01254 1052588001223 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1052588001224 Helix-turn-helix domains; Region: HTH; cl00088 1052588001225 NosL; Region: NosL; cl01769 1052588001226 Integrase core domain; Region: rve; cl01316 1052588001227 Integrase core domain; Region: rve_3; cl15866 1052588001228 HTH-like domain; Region: HTH_21; pfam13276 1052588001229 Integrase core domain; Region: rve; cl01316 1052588001230 Helix-turn-helix domains; Region: HTH; cl00088 1052588001231 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1052588001232 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1052588001233 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1052588001234 active site 1052588001235 P-loop; other site 1052588001236 phosphorylation site [posttranslational modification] 1052588001237 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1052588001238 active site 1052588001239 phosphorylation site [posttranslational modification] 1052588001240 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1052588001241 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1052588001242 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1052588001243 tartrate dehydrogenase; Provisional; Region: PRK08194 1052588001244 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1052588001245 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1052588001246 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1052588001247 Catalytic site [active] 1052588001248 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1052588001249 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1052588001250 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588001251 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1052588001252 active site 1052588001253 motif I; other site 1052588001254 motif II; other site 1052588001255 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588001256 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1052588001257 putative active site [active] 1052588001258 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1052588001259 Protein of unknown function (DUF1445); Region: DUF1445; cl01790 1052588001260 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1052588001261 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1052588001262 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 1052588001263 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1052588001264 Helix-turn-helix domains; Region: HTH; cl00088 1052588001265 Bacterial transcriptional regulator; Region: IclR; pfam01614 1052588001266 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1052588001267 active site 1052588001268 catalytic triad [active] 1052588001269 oxyanion hole [active] 1052588001270 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 1052588001271 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1052588001272 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1052588001273 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1052588001274 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1052588001275 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052588001276 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052588001277 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052588001278 active site 1052588001279 catalytic tetrad [active] 1052588001280 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1052588001281 Helix-turn-helix domains; Region: HTH; cl00088 1052588001282 PRD domain; Region: PRD; cl15445 1052588001283 PRD domain; Region: PRD; cl15445 1052588001284 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1052588001285 active site 1052588001286 P-loop; other site 1052588001287 phosphorylation site [posttranslational modification] 1052588001288 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1052588001289 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588001290 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588001291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588001292 S-adenosylmethionine binding site [chemical binding]; other site 1052588001293 short chain dehydrogenase; Provisional; Region: PRK06701 1052588001294 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1052588001295 NAD binding site [chemical binding]; other site 1052588001296 metal binding site [ion binding]; metal-binding site 1052588001297 active site 1052588001298 Cupin domain; Region: Cupin_2; cl09118 1052588001299 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052588001300 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052588001301 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1052588001302 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1052588001303 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 1052588001304 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 1052588001305 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1052588001306 Helix-turn-helix domains; Region: HTH; cl00088 1052588001307 AsnC family; Region: AsnC_trans_reg; pfam01037 1052588001308 DNA topoisomerase III; Provisional; Region: PRK07726 1052588001309 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1052588001310 active site 1052588001311 putative interdomain interaction site [polypeptide binding]; other site 1052588001312 putative metal-binding site [ion binding]; other site 1052588001313 putative nucleotide binding site [chemical binding]; other site 1052588001314 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1052588001315 domain I; other site 1052588001316 DNA binding groove [nucleotide binding] 1052588001317 phosphate binding site [ion binding]; other site 1052588001318 domain II; other site 1052588001319 domain III; other site 1052588001320 nucleotide binding site [chemical binding]; other site 1052588001321 catalytic site [active] 1052588001322 domain IV; other site 1052588001323 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1052588001324 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1052588001325 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1052588001326 CCC1-related family of proteins; Region: CCC1_like; cl00278 1052588001327 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1052588001328 metal binding site [ion binding]; metal-binding site 1052588001329 active site 1052588001330 I-site; other site 1052588001331 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 1052588001332 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 1052588001333 NodB motif; other site 1052588001334 putative active site [active] 1052588001335 putative catalytic site [active] 1052588001336 putative Zn binding site [ion binding]; other site 1052588001337 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1052588001338 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1052588001339 DXD motif; other site 1052588001340 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1052588001341 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1052588001342 K+ potassium transporter; Region: K_trans; cl15781 1052588001343 pyruvate oxidase; Provisional; Region: PRK08611 1052588001344 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1052588001345 PYR/PP interface [polypeptide binding]; other site 1052588001346 tetramer interface [polypeptide binding]; other site 1052588001347 dimer interface [polypeptide binding]; other site 1052588001348 TPP binding site [chemical binding]; other site 1052588001349 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1052588001350 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1052588001351 TPP-binding site [chemical binding]; other site 1052588001352 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 1052588001353 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1052588001354 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1052588001355 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1052588001356 EcsC protein family; Region: EcsC; pfam12787 1052588001357 General stress protein [General function prediction only]; Region: GsiB; COG3729 1052588001358 Cupin domain; Region: Cupin_2; cl09118 1052588001359 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1052588001360 dimanganese center [ion binding]; other site 1052588001361 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1052588001362 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1052588001363 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1052588001364 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1052588001365 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588001366 ATP binding site [chemical binding]; other site 1052588001367 Mg2+ binding site [ion binding]; other site 1052588001368 G-X-G motif; other site 1052588001369 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1052588001370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588001371 active site 1052588001372 phosphorylation site [posttranslational modification] 1052588001373 intermolecular recognition site; other site 1052588001374 dimerization interface [polypeptide binding]; other site 1052588001375 Helix-turn-helix domains; Region: HTH; cl00088 1052588001376 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1052588001377 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1052588001378 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052588001379 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588001380 Walker A/P-loop; other site 1052588001381 ATP binding site [chemical binding]; other site 1052588001382 Q-loop/lid; other site 1052588001383 ABC transporter signature motif; other site 1052588001384 Walker B; other site 1052588001385 D-loop; other site 1052588001386 H-loop/switch region; other site 1052588001387 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1052588001388 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1052588001389 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1052588001390 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1052588001391 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1052588001392 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 1052588001393 Cation efflux family; Region: Cation_efflux; cl00316 1052588001394 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1052588001395 catalytic residues [active] 1052588001396 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1052588001397 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1052588001398 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1052588001399 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1052588001400 helicase 45; Provisional; Region: PTZ00424 1052588001401 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1052588001402 ATP binding site [chemical binding]; other site 1052588001403 Mg++ binding site [ion binding]; other site 1052588001404 motif III; other site 1052588001405 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052588001406 nucleotide binding region [chemical binding]; other site 1052588001407 ATP-binding site [chemical binding]; other site 1052588001408 Bacterial PH domain; Region: DUF304; cl01348 1052588001409 Predicted membrane protein [Function unknown]; Region: COG3428 1052588001410 Bacterial PH domain; Region: DUF304; cl01348 1052588001411 Bacterial PH domain; Region: DUF304; cl01348 1052588001412 Bacterial PH domain; Region: DUF304; cl01348 1052588001413 Rhomboid family; Region: Rhomboid; cl11446 1052588001414 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1052588001415 alanine racemase; Region: alr; TIGR00492 1052588001416 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1052588001417 active site 1052588001418 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1052588001419 dimer interface [polypeptide binding]; other site 1052588001420 substrate binding site [chemical binding]; other site 1052588001421 catalytic residues [active] 1052588001422 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1052588001423 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 1052588001424 PemK-like protein; Region: PemK; cl00995 1052588001425 Rsbr N terminal; Region: Rsbr_N; pfam08678 1052588001426 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1052588001427 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1052588001428 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1052588001429 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588001430 ATP binding site [chemical binding]; other site 1052588001431 Mg2+ binding site [ion binding]; other site 1052588001432 G-X-G motif; other site 1052588001433 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1052588001434 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1052588001435 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1052588001436 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1052588001437 anti sigma factor interaction site; other site 1052588001438 regulatory phosphorylation site [posttranslational modification]; other site 1052588001439 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1052588001440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588001441 ATP binding site [chemical binding]; other site 1052588001442 Mg2+ binding site [ion binding]; other site 1052588001443 G-X-G motif; other site 1052588001444 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 1052588001445 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052588001446 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1052588001447 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588001448 DNA binding residues [nucleotide binding] 1052588001449 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 1052588001450 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1052588001451 EVE domain; Region: EVE; cl00728 1052588001452 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588001453 Helix-turn-helix domains; Region: HTH; cl00088 1052588001454 Helix-turn-helix domains; Region: HTH; cl00088 1052588001455 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1052588001456 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1052588001457 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 1052588001458 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1052588001459 RNA binding site [nucleotide binding]; other site 1052588001460 SprT homologues; Region: SprT; cl01182 1052588001461 hypothetical protein; Provisional; Region: PRK04351 1052588001462 potential frameshift: common BLAST hit: gi|350264743|ref|YP_004876050.1| luciferase family protein 1052588001463 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1052588001464 potential frameshift: common BLAST hit: gi|350264743|ref|YP_004876050.1| luciferase family protein 1052588001465 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1052588001466 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1052588001467 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052588001468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588001469 putative substrate translocation pore; other site 1052588001470 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1052588001471 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1052588001472 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052588001473 non-specific DNA binding site [nucleotide binding]; other site 1052588001474 salt bridge; other site 1052588001475 sequence-specific DNA binding site [nucleotide binding]; other site 1052588001476 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1052588001477 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1052588001478 putative di-iron ligands [ion binding]; other site 1052588001479 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1052588001480 DNA-binding site [nucleotide binding]; DNA binding site 1052588001481 RNA-binding motif; other site 1052588001482 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1052588001483 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1052588001484 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588001485 DNA-binding site [nucleotide binding]; DNA binding site 1052588001486 FCD domain; Region: FCD; cl11656 1052588001487 cyanate transporter; Region: CynX; TIGR00896 1052588001488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588001489 putative substrate translocation pore; other site 1052588001490 Cupin domain; Region: Cupin_2; cl09118 1052588001491 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052588001492 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052588001493 EamA-like transporter family; Region: EamA; cl01037 1052588001494 EamA-like transporter family; Region: EamA; cl01037 1052588001495 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052588001496 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052588001497 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1052588001498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588001499 putative substrate translocation pore; other site 1052588001500 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1052588001501 Protein of unknown function (DUF419); Region: DUF419; cl15265 1052588001502 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1052588001503 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1052588001504 Response regulator receiver domain; Region: Response_reg; pfam00072 1052588001505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588001506 active site 1052588001507 phosphorylation site [posttranslational modification] 1052588001508 intermolecular recognition site; other site 1052588001509 dimerization interface [polypeptide binding]; other site 1052588001510 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052588001511 Helix-turn-helix domains; Region: HTH; cl00088 1052588001512 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1052588001513 putative dimerization interface [polypeptide binding]; other site 1052588001514 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1052588001515 Class II fumarases; Region: Fumarase_classII; cd01362 1052588001516 active site 1052588001517 tetramer interface [polypeptide binding]; other site 1052588001518 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052588001519 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1052588001520 Helix-turn-helix domains; Region: HTH; cl00088 1052588001521 AsnC family; Region: AsnC_trans_reg; pfam01037 1052588001522 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1052588001523 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588001524 DNA-binding site [nucleotide binding]; DNA binding site 1052588001525 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052588001526 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588001527 homodimer interface [polypeptide binding]; other site 1052588001528 catalytic residue [active] 1052588001529 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1052588001530 putative active site [active] 1052588001531 putative catalytic site [active] 1052588001532 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052588001533 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052588001534 Helix-turn-helix domains; Region: HTH; cl00088 1052588001535 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1052588001536 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052588001537 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052588001538 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 1052588001539 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052588001540 dimerization interface [polypeptide binding]; other site 1052588001541 putative DNA binding site [nucleotide binding]; other site 1052588001542 putative Zn2+ binding site [ion binding]; other site 1052588001543 arsenical pump membrane protein; Provisional; Region: PRK15445 1052588001544 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1052588001545 transmembrane helices; other site 1052588001546 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1052588001547 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1052588001548 active site 1052588001549 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052588001550 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1052588001551 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1052588001552 NodB motif; other site 1052588001553 active site 1052588001554 catalytic site [active] 1052588001555 Zn binding site [ion binding]; other site 1052588001556 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1052588001557 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1052588001558 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052588001559 dimerization interface [polypeptide binding]; other site 1052588001560 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052588001561 dimer interface [polypeptide binding]; other site 1052588001562 phosphorylation site [posttranslational modification] 1052588001563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588001564 ATP binding site [chemical binding]; other site 1052588001565 Mg2+ binding site [ion binding]; other site 1052588001566 G-X-G motif; other site 1052588001567 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052588001568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588001569 active site 1052588001570 phosphorylation site [posttranslational modification] 1052588001571 intermolecular recognition site; other site 1052588001572 dimerization interface [polypeptide binding]; other site 1052588001573 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052588001574 DNA binding site [nucleotide binding] 1052588001575 EamA-like transporter family; Region: EamA; cl01037 1052588001576 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1052588001577 EamA-like transporter family; Region: EamA; cl01037 1052588001578 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1052588001579 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588001580 DNA-binding site [nucleotide binding]; DNA binding site 1052588001581 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052588001582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588001583 homodimer interface [polypeptide binding]; other site 1052588001584 catalytic residue [active] 1052588001585 Flavin Reductases; Region: FlaRed; cl00801 1052588001586 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052588001587 putative DNA binding site [nucleotide binding]; other site 1052588001588 putative Zn2+ binding site [ion binding]; other site 1052588001589 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1052588001590 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052588001591 Histidine kinase; Region: HisKA_3; pfam07730 1052588001592 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588001593 ATP binding site [chemical binding]; other site 1052588001594 Mg2+ binding site [ion binding]; other site 1052588001595 G-X-G motif; other site 1052588001596 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052588001597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588001598 active site 1052588001599 phosphorylation site [posttranslational modification] 1052588001600 intermolecular recognition site; other site 1052588001601 dimerization interface [polypeptide binding]; other site 1052588001602 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052588001603 DNA binding residues [nucleotide binding] 1052588001604 dimerization interface [polypeptide binding]; other site 1052588001605 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1052588001606 Protein of unknown function (DUF554); Region: DUF554; cl00784 1052588001607 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1052588001608 DNA binding residues [nucleotide binding] 1052588001609 drug binding residues [chemical binding]; other site 1052588001610 dimer interface [polypeptide binding]; other site 1052588001611 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1052588001612 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1052588001613 Cation efflux family; Region: Cation_efflux; cl00316 1052588001614 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1052588001615 dimer interface [polypeptide binding]; other site 1052588001616 FMN binding site [chemical binding]; other site 1052588001617 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1052588001618 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052588001619 Zn binding site [ion binding]; other site 1052588001620 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1052588001621 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052588001622 Zn binding site [ion binding]; other site 1052588001623 DoxX; Region: DoxX; cl00976 1052588001624 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1052588001625 catalytic residues [active] 1052588001626 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1052588001627 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1052588001628 Protein of unknown function (DUF421); Region: DUF421; cl00990 1052588001629 Protein of unknown function (DUF421); Region: DUF421; cl00990 1052588001630 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1052588001631 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1052588001632 putative dimer interface [polypeptide binding]; other site 1052588001633 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1052588001634 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1052588001635 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052588001636 Helix-turn-helix domains; Region: HTH; cl00088 1052588001637 DoxX; Region: DoxX; cl00976 1052588001638 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588001639 Coenzyme A binding pocket [chemical binding]; other site 1052588001640 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1052588001641 nucleotide binding site/active site [active] 1052588001642 HIT family signature motif; other site 1052588001643 catalytic residue [active] 1052588001644 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052588001645 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588001646 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1052588001647 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052588001648 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052588001649 DNA binding site [nucleotide binding] 1052588001650 domain linker motif; other site 1052588001651 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1052588001652 dimerization interface [polypeptide binding]; other site 1052588001653 ligand binding site [chemical binding]; other site 1052588001654 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1052588001655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588001656 putative substrate translocation pore; other site 1052588001657 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1052588001658 UV-endonuclease UvdE; Region: UvdE; cl10036 1052588001659 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1052588001660 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1052588001661 ABC transporter; Region: ABC_tran_2; pfam12848 1052588001662 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1052588001663 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1052588001664 Spore germination protein; Region: Spore_permease; cl15802 1052588001665 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1052588001666 DinB superfamily; Region: DinB_2; pfam12867 1052588001667 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588001668 Helix-turn-helix domains; Region: HTH; cl00088 1052588001669 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1052588001670 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1052588001671 dimer interface [polypeptide binding]; other site 1052588001672 FMN binding site [chemical binding]; other site 1052588001673 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588001674 Helix-turn-helix domains; Region: HTH; cl00088 1052588001675 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1052588001676 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588001677 putative substrate translocation pore; other site 1052588001678 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 1052588001679 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1052588001680 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588001681 DNA-binding site [nucleotide binding]; DNA binding site 1052588001682 FCD domain; Region: FCD; cl11656 1052588001683 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1052588001684 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588001685 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588001686 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1052588001687 active site 1052588001688 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1052588001689 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1052588001690 homodimer interface [polypeptide binding]; other site 1052588001691 active site 1052588001692 TDP-binding site; other site 1052588001693 acceptor substrate-binding pocket; other site 1052588001694 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1052588001695 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1052588001696 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1052588001697 dimer interface [polypeptide binding]; other site 1052588001698 Alkaline phosphatase homologues; Region: alkPPc; smart00098 1052588001699 active site 1052588001700 Protein of unknown function (DUF419); Region: DUF419; cl15265 1052588001701 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588001702 Coenzyme A binding pocket [chemical binding]; other site 1052588001703 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1052588001704 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1052588001705 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1052588001706 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1052588001707 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052588001708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588001709 putative substrate translocation pore; other site 1052588001710 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1052588001711 active site 1052588001712 P-loop; other site 1052588001713 phosphorylation site [posttranslational modification] 1052588001714 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1052588001715 active site 1052588001716 methionine cluster; other site 1052588001717 phosphorylation site [posttranslational modification] 1052588001718 metal binding site [ion binding]; metal-binding site 1052588001719 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1052588001720 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1052588001721 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1052588001722 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1052588001723 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588001724 DNA-binding site [nucleotide binding]; DNA binding site 1052588001725 UTRA domain; Region: UTRA; cl01230 1052588001726 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1052588001727 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1052588001728 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1052588001729 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 1052588001730 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 1052588001731 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1052588001732 dimanganese center [ion binding]; other site 1052588001733 thiamine-monophosphate kinase; Region: thiL; TIGR01379 1052588001734 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1052588001735 ATP binding site [chemical binding]; other site 1052588001736 dimerization interface [polypeptide binding]; other site 1052588001737 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 1052588001738 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 1052588001739 Glycoprotease family; Region: Peptidase_M22; pfam00814 1052588001740 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1052588001741 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588001742 Coenzyme A binding pocket [chemical binding]; other site 1052588001743 UGMP family protein; Validated; Region: PRK09604 1052588001744 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 1052588001745 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1052588001746 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1052588001747 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1052588001748 ABC transporter; Region: ABC_tran_2; pfam12848 1052588001749 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1052588001750 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1052588001751 trimer interface [polypeptide binding]; other site 1052588001752 dimer interface [polypeptide binding]; other site 1052588001753 putative active site [active] 1052588001754 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1052588001755 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1052588001756 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588001757 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1052588001758 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 1052588001759 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 1052588001760 CAAX protease self-immunity; Region: Abi; cl00558 1052588001761 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1052588001762 oligomerisation interface [polypeptide binding]; other site 1052588001763 mobile loop; other site 1052588001764 roof hairpin; other site 1052588001765 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1052588001766 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1052588001767 ring oligomerisation interface [polypeptide binding]; other site 1052588001768 ATP/Mg binding site [chemical binding]; other site 1052588001769 stacking interactions; other site 1052588001770 hinge regions; other site 1052588001771 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052588001772 NB-ARC domain; Region: NB-ARC; pfam00931 1052588001773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1052588001774 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588001775 binding surface 1052588001776 TPR motif; other site 1052588001777 TPR repeat; Region: TPR_11; pfam13414 1052588001778 L-idonate 5-dehydrogenase; Region: PLN02702 1052588001779 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1052588001780 inhibitor binding site; inhibition site 1052588001781 catalytic Zn binding site [ion binding]; other site 1052588001782 structural Zn binding site [ion binding]; other site 1052588001783 NADP binding site [chemical binding]; other site 1052588001784 tetramer interface [polypeptide binding]; other site 1052588001785 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1052588001786 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1052588001787 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1052588001788 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1052588001789 putative substrate binding site [chemical binding]; other site 1052588001790 putative ATP binding site [chemical binding]; other site 1052588001791 Ion channel; Region: Ion_trans_2; cl11596 1052588001792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588001793 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1052588001794 putative substrate translocation pore; other site 1052588001795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588001796 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1052588001797 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1052588001798 putative NAD(P) binding site [chemical binding]; other site 1052588001799 catalytic Zn binding site [ion binding]; other site 1052588001800 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 1052588001801 Cold-inducible protein YdjO; Region: YdjO; pfam14169 1052588001802 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052588001803 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052588001804 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 1052588001805 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1052588001806 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1052588001807 Cation efflux family; Region: Cation_efflux; cl00316 1052588001808 MoxR-like ATPases [General function prediction only]; Region: COG0714 1052588001809 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588001810 Walker A motif; other site 1052588001811 ATP binding site [chemical binding]; other site 1052588001812 Walker B motif; other site 1052588001813 arginine finger; other site 1052588001814 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1052588001815 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1052588001816 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1052588001817 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 1052588001818 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1052588001819 GMP synthase; Reviewed; Region: guaA; PRK00074 1052588001820 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1052588001821 AMP/PPi binding site [chemical binding]; other site 1052588001822 candidate oxyanion hole; other site 1052588001823 catalytic triad [active] 1052588001824 potential glutamine specificity residues [chemical binding]; other site 1052588001825 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1052588001826 ATP Binding subdomain [chemical binding]; other site 1052588001827 Ligand Binding sites [chemical binding]; other site 1052588001828 Dimerization subdomain; other site 1052588001829 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 1052588001830 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052588001831 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588001832 DNA binding residues [nucleotide binding] 1052588001833 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1052588001834 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 1052588001835 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1052588001836 hypothetical protein; Provisional; Region: PRK04164 1052588001837 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 1052588001838 NETI protein; Region: NETI; pfam14044 1052588001839 AIR carboxylase; Region: AIRC; cl00310 1052588001840 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1052588001841 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588001842 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1052588001843 adenylosuccinate lyase; Provisional; Region: PRK07492 1052588001844 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1052588001845 tetramer interface [polypeptide binding]; other site 1052588001846 active site 1052588001847 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1052588001848 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1052588001849 ATP binding site [chemical binding]; other site 1052588001850 active site 1052588001851 substrate binding site [chemical binding]; other site 1052588001852 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 1052588001853 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1052588001854 putative active site [active] 1052588001855 catalytic triad [active] 1052588001856 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1052588001857 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1052588001858 dimerization interface [polypeptide binding]; other site 1052588001859 ATP binding site [chemical binding]; other site 1052588001860 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1052588001861 dimerization interface [polypeptide binding]; other site 1052588001862 ATP binding site [chemical binding]; other site 1052588001863 amidophosphoribosyltransferase; Provisional; Region: PRK07631 1052588001864 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1052588001865 active site 1052588001866 tetramer interface [polypeptide binding]; other site 1052588001867 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052588001868 active site 1052588001869 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1052588001870 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1052588001871 dimerization interface [polypeptide binding]; other site 1052588001872 putative ATP binding site [chemical binding]; other site 1052588001873 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1052588001874 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1052588001875 active site 1052588001876 substrate binding site [chemical binding]; other site 1052588001877 cosubstrate binding site; other site 1052588001878 catalytic site [active] 1052588001879 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1052588001880 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1052588001881 purine monophosphate binding site [chemical binding]; other site 1052588001882 dimer interface [polypeptide binding]; other site 1052588001883 putative catalytic residues [active] 1052588001884 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1052588001885 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1052588001886 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1052588001887 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1052588001888 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1052588001889 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1052588001890 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1052588001891 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052588001892 putative DNA binding site [nucleotide binding]; other site 1052588001893 putative Zn2+ binding site [ion binding]; other site 1052588001894 AsnC family; Region: AsnC_trans_reg; pfam01037 1052588001895 putative transporter; Provisional; Region: PRK11021 1052588001896 Spore germination protein; Region: Spore_permease; cl15802 1052588001897 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1052588001898 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1052588001899 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1052588001900 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1052588001901 active site 1052588001902 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1052588001903 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 1052588001904 Helix-turn-helix domains; Region: HTH; cl00088 1052588001905 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 1052588001906 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1052588001907 active site 1052588001908 FMN binding site [chemical binding]; other site 1052588001909 substrate binding site [chemical binding]; other site 1052588001910 3Fe-4S cluster binding site [ion binding]; other site 1052588001911 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1052588001912 substrate binding site [chemical binding]; other site 1052588001913 putative active site [active] 1052588001914 dimer interface [polypeptide binding]; other site 1052588001915 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1052588001916 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588001917 Family description; Region: UvrD_C_2; cl15862 1052588001918 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1052588001919 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1052588001920 nucleotide binding pocket [chemical binding]; other site 1052588001921 K-X-D-G motif; other site 1052588001922 catalytic site [active] 1052588001923 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1052588001924 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1052588001925 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1052588001926 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1052588001927 Dimer interface [polypeptide binding]; other site 1052588001928 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 1052588001929 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052588001930 active site 1052588001931 ATP binding site [chemical binding]; other site 1052588001932 substrate binding site [chemical binding]; other site 1052588001933 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1052588001934 MgtC family; Region: MgtC; pfam02308 1052588001935 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1052588001936 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1052588001937 Na binding site [ion binding]; other site 1052588001938 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 1052588001939 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1052588001940 Amidase; Region: Amidase; cl11426 1052588001941 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1052588001942 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1052588001943 GatB domain; Region: GatB_Yqey; cl11497 1052588001944 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052588001945 Helix-turn-helix domains; Region: HTH; cl00088 1052588001946 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1052588001947 Protein export membrane protein; Region: SecD_SecF; cl14618 1052588001948 Protein export membrane protein; Region: SecD_SecF; cl14618 1052588001949 putative lipid kinase; Reviewed; Region: PRK13337 1052588001950 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1052588001951 TRAM domain; Region: TRAM; cl01282 1052588001952 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1052588001953 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588001954 S-adenosylmethionine binding site [chemical binding]; other site 1052588001955 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1052588001956 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1052588001957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1052588001958 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1052588001959 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1052588001960 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1052588001961 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1052588001962 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1052588001963 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052588001964 ATP binding site [chemical binding]; other site 1052588001965 putative Mg++ binding site [ion binding]; other site 1052588001966 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 1052588001967 Protein of unknown function, DUF600; Region: DUF600; cl04640 1052588001968 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1052588001969 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 1052588001970 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 1052588001971 Transcriptional regulator; Region: Transcrip_reg; cl00361 1052588001972 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052588001973 Helix-turn-helix domains; Region: HTH; cl00088 1052588001974 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1052588001975 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1052588001976 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1052588001977 NADP binding site [chemical binding]; other site 1052588001978 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 1052588001979 CotJB protein; Region: CotJB; pfam12652 1052588001980 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1052588001981 dimanganese center [ion binding]; other site 1052588001982 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052588001983 YesK-like protein; Region: YesK; pfam14150 1052588001984 Protein of unknown function, DUF624; Region: DUF624; cl02369 1052588001985 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1052588001986 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1052588001987 Histidine kinase; Region: His_kinase; pfam06580 1052588001988 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588001989 ATP binding site [chemical binding]; other site 1052588001990 Mg2+ binding site [ion binding]; other site 1052588001991 G-X-G motif; other site 1052588001992 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 1052588001993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588001994 active site 1052588001995 phosphorylation site [posttranslational modification] 1052588001996 intermolecular recognition site; other site 1052588001997 dimerization interface [polypeptide binding]; other site 1052588001998 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052588001999 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052588002000 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1052588002001 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052588002002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588002003 dimer interface [polypeptide binding]; other site 1052588002004 conserved gate region; other site 1052588002005 putative PBP binding loops; other site 1052588002006 ABC-ATPase subunit interface; other site 1052588002007 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052588002008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588002009 dimer interface [polypeptide binding]; other site 1052588002010 conserved gate region; other site 1052588002011 putative PBP binding loops; other site 1052588002012 ABC-ATPase subunit interface; other site 1052588002013 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1052588002014 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052588002015 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052588002016 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1052588002017 active site 1052588002018 catalytic triad [active] 1052588002019 Domain of unknown function (DUF1961); Region: DUF1961; pfam09224 1052588002020 Protein of unknown function, DUF624; Region: DUF624; cl02369 1052588002021 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1052588002022 metal binding site [ion binding]; metal-binding site 1052588002023 active site 1052588002024 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1052588002025 metal binding site [ion binding]; metal-binding site 1052588002026 active site 1052588002027 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1052588002028 active site 1052588002029 catalytic triad [active] 1052588002030 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1052588002031 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 1052588002032 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1052588002033 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1052588002034 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1052588002035 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052588002036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588002037 dimer interface [polypeptide binding]; other site 1052588002038 putative PBP binding loops; other site 1052588002039 ABC-ATPase subunit interface; other site 1052588002040 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052588002041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588002042 dimer interface [polypeptide binding]; other site 1052588002043 conserved gate region; other site 1052588002044 putative PBP binding loops; other site 1052588002045 ABC-ATPase subunit interface; other site 1052588002046 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1052588002047 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1052588002048 NAD binding site [chemical binding]; other site 1052588002049 sugar binding site [chemical binding]; other site 1052588002050 divalent metal binding site [ion binding]; other site 1052588002051 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052588002052 dimer interface [polypeptide binding]; other site 1052588002053 Protein of unknown function (DUF421); Region: DUF421; cl00990 1052588002054 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1052588002055 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052588002056 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1052588002057 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1052588002058 Uncharacterized small protein (DUF2292); Region: DUF2292; cl02371 1052588002059 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1052588002060 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588002061 Helix-turn-helix domains; Region: HTH; cl00088 1052588002062 hypothetical protein; Provisional; Region: PRK06847 1052588002063 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588002064 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 1052588002065 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 1052588002066 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1052588002067 Cytochrome P450; Region: p450; pfam00067 1052588002068 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1052588002069 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1052588002070 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1052588002071 FAD binding pocket [chemical binding]; other site 1052588002072 FAD binding motif [chemical binding]; other site 1052588002073 catalytic residues [active] 1052588002074 NAD binding pocket [chemical binding]; other site 1052588002075 phosphate binding motif [ion binding]; other site 1052588002076 beta-alpha-beta structure motif; other site 1052588002077 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1052588002078 Sulfatase; Region: Sulfatase; cl10460 1052588002079 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1052588002080 substrate binding site; other site 1052588002081 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588002082 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 1052588002083 NAD(P) binding site [chemical binding]; other site 1052588002084 active site 1052588002085 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1052588002086 Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; cl05288 1052588002087 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588002088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588002089 putative substrate translocation pore; other site 1052588002090 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1052588002091 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588002092 active site 1052588002093 motif I; other site 1052588002094 motif II; other site 1052588002095 amino acid transporter; Region: 2A0306; TIGR00909 1052588002096 Spore germination protein; Region: Spore_permease; cl15802 1052588002097 Spore germination protein; Region: Spore_permease; cl15802 1052588002098 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1052588002099 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052588002100 dimer interface [polypeptide binding]; other site 1052588002101 putative CheW interface [polypeptide binding]; other site 1052588002102 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1052588002103 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588002104 Walker A/P-loop; other site 1052588002105 ATP binding site [chemical binding]; other site 1052588002106 Q-loop/lid; other site 1052588002107 ABC transporter signature motif; other site 1052588002108 Walker B; other site 1052588002109 D-loop; other site 1052588002110 H-loop/switch region; other site 1052588002111 ABC transporter; Region: ABC_tran_2; pfam12848 1052588002112 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1052588002113 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 1052588002114 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 1052588002115 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1052588002116 DNA binding residues [nucleotide binding] 1052588002117 putative dimer interface [polypeptide binding]; other site 1052588002118 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052588002119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588002120 putative substrate translocation pore; other site 1052588002121 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1052588002122 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588002123 Walker A/P-loop; other site 1052588002124 ATP binding site [chemical binding]; other site 1052588002125 Q-loop/lid; other site 1052588002126 ABC transporter signature motif; other site 1052588002127 Walker B; other site 1052588002128 D-loop; other site 1052588002129 H-loop/switch region; other site 1052588002130 ABC transporter; Region: ABC_tran_2; pfam12848 1052588002131 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1052588002132 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1052588002133 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1052588002134 ATP binding site [chemical binding]; other site 1052588002135 Mg++ binding site [ion binding]; other site 1052588002136 motif III; other site 1052588002137 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052588002138 nucleotide binding region [chemical binding]; other site 1052588002139 ATP-binding site [chemical binding]; other site 1052588002140 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1052588002141 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052588002142 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1052588002143 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1052588002144 NAD(P) binding site [chemical binding]; other site 1052588002145 substrate binding site [chemical binding]; other site 1052588002146 dimer interface [polypeptide binding]; other site 1052588002147 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1052588002148 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1052588002149 Walker A/P-loop; other site 1052588002150 ATP binding site [chemical binding]; other site 1052588002151 Q-loop/lid; other site 1052588002152 ABC transporter signature motif; other site 1052588002153 Walker B; other site 1052588002154 D-loop; other site 1052588002155 H-loop/switch region; other site 1052588002156 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052588002157 ABC-ATPase subunit interface; other site 1052588002158 dimer interface [polypeptide binding]; other site 1052588002159 putative PBP binding regions; other site 1052588002160 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052588002161 ABC-ATPase subunit interface; other site 1052588002162 dimer interface [polypeptide binding]; other site 1052588002163 putative PBP binding regions; other site 1052588002164 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1052588002165 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1052588002166 siderophore binding site; other site 1052588002167 Protein of unknown function (DUF3212); Region: DUF3212; pfam11486 1052588002168 Heat induced stress protein YflT; Region: YflT; pfam11181 1052588002169 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1052588002170 Pectate lyase; Region: Pec_lyase_C; cl01593 1052588002171 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1052588002172 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1052588002173 transmembrane helices; other site 1052588002174 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 1052588002175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588002176 S-adenosylmethionine binding site [chemical binding]; other site 1052588002177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1052588002178 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1052588002179 putative metal binding site; other site 1052588002180 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588002181 binding surface 1052588002182 TPR motif; other site 1052588002183 TPR repeat; Region: TPR_11; pfam13414 1052588002184 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588002185 binding surface 1052588002186 TPR motif; other site 1052588002187 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 1052588002188 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1052588002189 Probable Catalytic site; other site 1052588002190 metal-binding site 1052588002191 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1052588002192 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1052588002193 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588002194 ATP binding site [chemical binding]; other site 1052588002195 Mg2+ binding site [ion binding]; other site 1052588002196 G-X-G motif; other site 1052588002197 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1052588002198 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588002199 active site 1052588002200 phosphorylation site [posttranslational modification] 1052588002201 intermolecular recognition site; other site 1052588002202 dimerization interface [polypeptide binding]; other site 1052588002203 Transcriptional regulator; Region: CitT; pfam12431 1052588002204 Helix-turn-helix domains; Region: HTH; cl00088 1052588002205 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1052588002206 NMT1-like family; Region: NMT1_2; cl15260 1052588002207 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 1052588002208 Citrate transporter; Region: CitMHS; pfam03600 1052588002209 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052588002210 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 1052588002211 active site 1052588002212 dimer interface [polypeptide binding]; other site 1052588002213 Acylphosphatase; Region: Acylphosphatase; cl00551 1052588002214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1052588002215 MOSC domain; Region: MOSC; pfam03473 1052588002216 3-alpha domain; Region: 3-alpha; pfam03475 1052588002217 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 1052588002218 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1052588002219 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1052588002220 active site 1052588002221 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1052588002222 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1052588002223 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052588002224 active site turn [active] 1052588002225 phosphorylation site [posttranslational modification] 1052588002226 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1052588002227 Sulfatase; Region: Sulfatase; cl10460 1052588002228 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 1052588002229 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1052588002230 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1052588002231 Spore germination protein; Region: Spore_permease; cl15802 1052588002232 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 1052588002233 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1052588002234 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1052588002235 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052588002236 active site turn [active] 1052588002237 phosphorylation site [posttranslational modification] 1052588002238 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1052588002239 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1052588002240 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1052588002241 Ca binding site [ion binding]; other site 1052588002242 active site 1052588002243 catalytic site [active] 1052588002244 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1052588002245 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588002246 DNA-binding site [nucleotide binding]; DNA binding site 1052588002247 UTRA domain; Region: UTRA; cl01230 1052588002248 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1052588002249 dimer interface [polypeptide binding]; other site 1052588002250 FMN binding site [chemical binding]; other site 1052588002251 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 1052588002252 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1052588002253 active site 1052588002254 metal binding site [ion binding]; metal-binding site 1052588002255 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1052588002256 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 1052588002257 active site 1052588002258 metal binding site [ion binding]; metal-binding site 1052588002259 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1052588002260 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1052588002261 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1052588002262 proposed catalytic triad [active] 1052588002263 conserved cys residue [active] 1052588002264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588002265 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588002266 putative substrate translocation pore; other site 1052588002267 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 1052588002268 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1052588002269 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1052588002270 active site 1052588002271 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1052588002272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588002273 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588002274 putative substrate translocation pore; other site 1052588002275 calcium/proton exchanger (cax); Region: cax; TIGR00378 1052588002276 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1052588002277 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1052588002278 YfkD-like protein; Region: YfkD; pfam14167 1052588002279 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1052588002280 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1052588002281 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052588002282 FeS/SAM binding site; other site 1052588002283 YfkB-like domain; Region: YfkB; pfam08756 1052588002284 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 1052588002285 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1052588002286 NodB motif; other site 1052588002287 active site 1052588002288 catalytic site [active] 1052588002289 Cd binding site [ion binding]; other site 1052588002290 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1052588002291 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588002292 magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383 1052588002293 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 1052588002294 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1052588002295 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1052588002296 minor groove reading motif; other site 1052588002297 helix-hairpin-helix signature motif; other site 1052588002298 substrate binding pocket [chemical binding]; other site 1052588002299 active site 1052588002300 TRAM domain; Region: TRAM; cl01282 1052588002301 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1052588002302 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588002303 S-adenosylmethionine binding site [chemical binding]; other site 1052588002304 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1052588002305 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1052588002306 FMN binding site [chemical binding]; other site 1052588002307 active site 1052588002308 catalytic residues [active] 1052588002309 substrate binding site [chemical binding]; other site 1052588002310 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1052588002311 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1052588002312 tetramer interface [polypeptide binding]; other site 1052588002313 TPP-binding site [chemical binding]; other site 1052588002314 heterodimer interface [polypeptide binding]; other site 1052588002315 phosphorylation loop region [posttranslational modification] 1052588002316 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1052588002317 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1052588002318 alpha subunit interface [polypeptide binding]; other site 1052588002319 TPP binding site [chemical binding]; other site 1052588002320 heterodimer interface [polypeptide binding]; other site 1052588002321 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1052588002322 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1052588002323 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1052588002324 E3 interaction surface; other site 1052588002325 lipoyl attachment site [posttranslational modification]; other site 1052588002326 e3 binding domain; Region: E3_binding; pfam02817 1052588002327 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 1052588002328 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 1052588002329 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052588002330 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1052588002331 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1052588002332 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588002333 Walker A motif; other site 1052588002334 ATP binding site [chemical binding]; other site 1052588002335 Walker B motif; other site 1052588002336 arginine finger; other site 1052588002337 Helix-turn-helix domains; Region: HTH; cl00088 1052588002338 Small acid-soluble spore protein H family; Region: SspH; cl06949 1052588002339 Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 1052588002340 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1052588002341 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 1052588002342 LXG domain of WXG superfamily; Region: LXG; pfam04740 1052588002343 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1052588002344 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 1052588002345 NAD binding site [chemical binding]; other site 1052588002346 sugar binding site [chemical binding]; other site 1052588002347 divalent metal binding site [ion binding]; other site 1052588002348 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052588002349 dimer interface [polypeptide binding]; other site 1052588002350 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1052588002351 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1052588002352 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1052588002353 putative active site [active] 1052588002354 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1052588002355 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1052588002356 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052588002357 active site turn [active] 1052588002358 phosphorylation site [posttranslational modification] 1052588002359 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052588002360 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1052588002361 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588002362 Walker A/P-loop; other site 1052588002363 ATP binding site [chemical binding]; other site 1052588002364 Q-loop/lid; other site 1052588002365 ABC transporter signature motif; other site 1052588002366 Walker B; other site 1052588002367 D-loop; other site 1052588002368 H-loop/switch region; other site 1052588002369 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052588002370 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1052588002371 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 1052588002372 Walker A/P-loop; other site 1052588002373 ATP binding site [chemical binding]; other site 1052588002374 Q-loop/lid; other site 1052588002375 ABC transporter signature motif; other site 1052588002376 Walker B; other site 1052588002377 D-loop; other site 1052588002378 H-loop/switch region; other site 1052588002379 DoxX; Region: DoxX; cl00976 1052588002380 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1052588002381 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1052588002382 putative metal binding site [ion binding]; other site 1052588002383 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1052588002384 active site 1052588002385 metal binding site [ion binding]; metal-binding site 1052588002386 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052588002387 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052588002388 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052588002389 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1052588002390 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1052588002391 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052588002392 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588002393 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1052588002394 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052588002395 Histidine kinase; Region: HisKA_3; pfam07730 1052588002396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588002397 ATP binding site [chemical binding]; other site 1052588002398 Mg2+ binding site [ion binding]; other site 1052588002399 G-X-G motif; other site 1052588002400 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052588002401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588002402 active site 1052588002403 phosphorylation site [posttranslational modification] 1052588002404 intermolecular recognition site; other site 1052588002405 dimerization interface [polypeptide binding]; other site 1052588002406 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052588002407 DNA binding residues [nucleotide binding] 1052588002408 dimerization interface [polypeptide binding]; other site 1052588002409 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588002410 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1052588002411 Walker A/P-loop; other site 1052588002412 ATP binding site [chemical binding]; other site 1052588002413 Q-loop/lid; other site 1052588002414 ABC transporter signature motif; other site 1052588002415 Walker B; other site 1052588002416 D-loop; other site 1052588002417 H-loop/switch region; other site 1052588002418 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1052588002419 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1052588002420 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1052588002421 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1052588002422 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1052588002423 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052588002424 Helix-turn-helix domains; Region: HTH; cl00088 1052588002425 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1052588002426 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052588002427 OpgC protein; Region: OpgC_C; cl00792 1052588002428 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1052588002429 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1052588002430 DinB superfamily; Region: DinB_2; pfam12867 1052588002431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588002432 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588002433 putative substrate translocation pore; other site 1052588002434 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588002435 Helix-turn-helix domains; Region: HTH; cl00088 1052588002436 Predicted integral membrane protein [Function unknown]; Region: COG0392 1052588002437 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 1052588002438 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1052588002439 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 1052588002440 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1052588002441 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1052588002442 siderophore binding site; other site 1052588002443 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052588002444 ABC-ATPase subunit interface; other site 1052588002445 dimer interface [polypeptide binding]; other site 1052588002446 putative PBP binding regions; other site 1052588002447 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1052588002448 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052588002449 ABC-ATPase subunit interface; other site 1052588002450 dimer interface [polypeptide binding]; other site 1052588002451 putative PBP binding regions; other site 1052588002452 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 1052588002453 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1052588002454 putative FMN binding site [chemical binding]; other site 1052588002455 YfhD-like protein; Region: YfhD; pfam14151 1052588002456 YfhE-like protein; Region: YfhE; pfam14152 1052588002457 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1052588002458 TIGR01777 family protein; Region: yfcH 1052588002459 putative NAD(P) binding site [chemical binding]; other site 1052588002460 putative active site [active] 1052588002461 RecX family; Region: RecX; cl00936 1052588002462 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1052588002463 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052588002464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588002465 putative substrate translocation pore; other site 1052588002466 Small acid-soluble spore protein K family; Region: SspK; cl11509 1052588002467 WVELL protein; Region: WVELL; pfam14043 1052588002468 Bacterial SH3 domain; Region: SH3_3; cl02551 1052588002469 Bacterial SH3 domain; Region: SH3_3; cl02551 1052588002470 SdpI/YhfL protein family; Region: SdpI; pfam13630 1052588002471 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1052588002472 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1052588002473 Ligand binding site; other site 1052588002474 Putative Catalytic site; other site 1052588002475 DXD motif; other site 1052588002476 Predicted membrane protein [Function unknown]; Region: COG4485 1052588002477 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 1052588002478 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 1052588002479 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1052588002480 minor groove reading motif; other site 1052588002481 helix-hairpin-helix signature motif; other site 1052588002482 substrate binding pocket [chemical binding]; other site 1052588002483 active site 1052588002484 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1052588002485 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1052588002486 DNA binding and oxoG recognition site [nucleotide binding] 1052588002487 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1052588002488 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 1052588002489 putative NAD(P) binding site [chemical binding]; other site 1052588002490 active site 1052588002491 YgaB-like protein; Region: YgaB; pfam14182 1052588002492 Protein of unknown function (DUF402); Region: DUF402; cl00979 1052588002493 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052588002494 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1052588002495 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 1052588002496 Walker A/P-loop; other site 1052588002497 ATP binding site [chemical binding]; other site 1052588002498 Q-loop/lid; other site 1052588002499 ABC transporter signature motif; other site 1052588002500 Walker B; other site 1052588002501 D-loop; other site 1052588002502 H-loop/switch region; other site 1052588002503 Predicted membrane protein [Function unknown]; Region: COG4129 1052588002504 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 1052588002505 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1052588002506 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052588002507 inhibitor-cofactor binding pocket; inhibition site 1052588002508 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588002509 catalytic residue [active] 1052588002510 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1052588002511 catalytic triad [active] 1052588002512 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1052588002513 metal binding site 2 [ion binding]; metal-binding site 1052588002514 putative DNA binding helix; other site 1052588002515 metal binding site 1 [ion binding]; metal-binding site 1052588002516 dimer interface [polypeptide binding]; other site 1052588002517 structural Zn2+ binding site [ion binding]; other site 1052588002518 Protein of unknown function (DUF2614); Region: DUF2614; cl07936 1052588002519 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 1052588002520 SpoOM protein; Region: Spo0M; pfam07070 1052588002521 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1052588002522 Coat F domain; Region: Coat_F; cl15836 1052588002523 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1052588002524 active site pocket [active] 1052588002525 oxyanion hole [active] 1052588002526 catalytic triad [active] 1052588002527 active site nucleophile [active] 1052588002528 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1052588002529 ThiC-associated domain; Region: ThiC-associated; pfam13667 1052588002530 ThiC family; Region: ThiC; cl08031 1052588002531 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1052588002532 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1052588002533 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1052588002534 tetramer interface [polypeptide binding]; other site 1052588002535 heme binding pocket [chemical binding]; other site 1052588002536 NADPH binding site [chemical binding]; other site 1052588002537 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 1052588002538 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1052588002539 Walker A/P-loop; other site 1052588002540 ATP binding site [chemical binding]; other site 1052588002541 Q-loop/lid; other site 1052588002542 ABC transporter signature motif; other site 1052588002543 Walker B; other site 1052588002544 D-loop; other site 1052588002545 H-loop/switch region; other site 1052588002546 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1052588002547 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1052588002548 substrate binding pocket [chemical binding]; other site 1052588002549 membrane-bound complex binding site; other site 1052588002550 hinge residues; other site 1052588002551 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1052588002552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588002553 dimer interface [polypeptide binding]; other site 1052588002554 conserved gate region; other site 1052588002555 putative PBP binding loops; other site 1052588002556 ABC-ATPase subunit interface; other site 1052588002557 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1052588002558 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1052588002559 active site 1052588002560 dimer interface [polypeptide binding]; other site 1052588002561 non-prolyl cis peptide bond; other site 1052588002562 insertion regions; other site 1052588002563 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 1052588002564 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052588002565 non-specific DNA binding site [nucleotide binding]; other site 1052588002566 salt bridge; other site 1052588002567 sequence-specific DNA binding site [nucleotide binding]; other site 1052588002568 B3/4 domain; Region: B3_4; cl11458 1052588002569 iron-sulfur cluster binding protein, putative; Region: TIGR00276 1052588002570 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1052588002571 HEAT repeats; Region: HEAT_2; pfam13646 1052588002572 NlpC/P60 family; Region: NLPC_P60; cl11438 1052588002573 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1052588002574 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 1052588002575 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 1052588002576 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1052588002577 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1052588002578 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 1052588002579 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1052588002580 Uncharacterized conserved protein [Function unknown]; Region: COG2718 1052588002581 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1052588002582 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588002583 Helix-turn-helix domains; Region: HTH; cl00088 1052588002584 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1052588002585 carboxyltransferase (CT) interaction site; other site 1052588002586 biotinylation site [posttranslational modification]; other site 1052588002587 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1052588002588 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1052588002589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588002590 putative substrate translocation pore; other site 1052588002591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588002592 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1052588002593 Predicted transcriptional regulators [Transcription]; Region: COG1725 1052588002594 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588002595 DNA-binding site [nucleotide binding]; DNA binding site 1052588002596 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1052588002597 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1052588002598 Walker A/P-loop; other site 1052588002599 ATP binding site [chemical binding]; other site 1052588002600 Q-loop/lid; other site 1052588002601 ABC transporter signature motif; other site 1052588002602 Walker B; other site 1052588002603 D-loop; other site 1052588002604 H-loop/switch region; other site 1052588002605 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052588002606 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 1052588002607 Walker A/P-loop; other site 1052588002608 ATP binding site [chemical binding]; other site 1052588002609 Q-loop/lid; other site 1052588002610 ABC transporter signature motif; other site 1052588002611 Walker B; other site 1052588002612 D-loop; other site 1052588002613 H-loop/switch region; other site 1052588002614 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1052588002615 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1052588002616 DNA-binding site [nucleotide binding]; DNA binding site 1052588002617 RNA-binding motif; other site 1052588002618 NMT1-like family; Region: NMT1_2; cl15260 1052588002619 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 1052588002620 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1052588002621 metal binding site [ion binding]; metal-binding site 1052588002622 active site 1052588002623 I-site; other site 1052588002624 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1052588002625 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1052588002626 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1052588002627 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1052588002628 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG4085 1052588002629 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1052588002630 generic binding surface II; other site 1052588002631 generic binding surface I; other site 1052588002632 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1052588002633 generic binding surface II; other site 1052588002634 generic binding surface I; other site 1052588002635 Staphylococcal nuclease homologues; Region: SNc; smart00318 1052588002636 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1052588002637 Catalytic site; other site 1052588002638 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1052588002639 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1052588002640 putative active site [active] 1052588002641 putative metal binding site [ion binding]; other site 1052588002642 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1052588002643 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 1052588002644 active site 1052588002645 catalytic site [active] 1052588002646 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1052588002647 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1052588002648 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1052588002649 active site 1052588002650 FOG: CBS domain [General function prediction only]; Region: COG0517 1052588002651 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1052588002652 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588002653 motif II; other site 1052588002654 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588002655 Coenzyme A binding pocket [chemical binding]; other site 1052588002656 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1052588002657 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 1052588002658 putative active site [active] 1052588002659 catalytic triad [active] 1052588002660 putative dimer interface [polypeptide binding]; other site 1052588002661 aminotransferase; Validated; Region: PRK07678 1052588002662 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052588002663 inhibitor-cofactor binding pocket; inhibition site 1052588002664 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588002665 catalytic residue [active] 1052588002666 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 1052588002667 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1052588002668 amphipathic channel; other site 1052588002669 Asn-Pro-Ala signature motifs; other site 1052588002670 glycerol kinase; Provisional; Region: glpK; PRK00047 1052588002671 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1052588002672 N- and C-terminal domain interface [polypeptide binding]; other site 1052588002673 active site 1052588002674 MgATP binding site [chemical binding]; other site 1052588002675 catalytic site [active] 1052588002676 metal binding site [ion binding]; metal-binding site 1052588002677 glycerol binding site [chemical binding]; other site 1052588002678 homotetramer interface [polypeptide binding]; other site 1052588002679 homodimer interface [polypeptide binding]; other site 1052588002680 FBP binding site [chemical binding]; other site 1052588002681 protein IIAGlc interface [polypeptide binding]; other site 1052588002682 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1052588002683 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1052588002684 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1052588002685 active site 1052588002686 substrate binding site [chemical binding]; other site 1052588002687 metal binding site [ion binding]; metal-binding site 1052588002688 GAF domain; Region: GAF_2; pfam13185 1052588002689 GAF domain; Region: GAF; cl15785 1052588002690 Histidine kinase; Region: HisKA_3; pfam07730 1052588002691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588002692 ATP binding site [chemical binding]; other site 1052588002693 Mg2+ binding site [ion binding]; other site 1052588002694 G-X-G motif; other site 1052588002695 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052588002696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588002697 active site 1052588002698 phosphorylation site [posttranslational modification] 1052588002699 intermolecular recognition site; other site 1052588002700 dimerization interface [polypeptide binding]; other site 1052588002701 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052588002702 DNA binding residues [nucleotide binding] 1052588002703 dimerization interface [polypeptide binding]; other site 1052588002704 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1052588002705 YhdB-like protein; Region: YhdB; pfam14148 1052588002706 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1052588002707 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588002708 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588002709 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588002710 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588002711 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 1052588002712 NlpC/P60 family; Region: NLPC_P60; cl11438 1052588002713 Helix-turn-helix domains; Region: HTH; cl00088 1052588002714 Rrf2 family protein; Region: rrf2_super; TIGR00738 1052588002715 Conserved TM helix; Region: TM_helix; pfam05552 1052588002716 Conserved TM helix; Region: TM_helix; pfam05552 1052588002717 Conserved TM helix; Region: TM_helix; pfam05552 1052588002718 Conserved TM helix; Region: TM_helix; pfam05552 1052588002719 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1052588002720 SpoVR like protein; Region: SpoVR; pfam04293 1052588002721 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1052588002722 dimer interface [polypeptide binding]; other site 1052588002723 Alkaline phosphatase homologues; Region: alkPPc; smart00098 1052588002724 active site 1052588002725 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588002726 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588002727 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588002728 NlpC/P60 family; Region: NLPC_P60; cl11438 1052588002729 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052588002730 Helix-turn-helix domains; Region: HTH; cl00088 1052588002731 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052588002732 dimerization interface [polypeptide binding]; other site 1052588002733 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1052588002734 dimer interface [polypeptide binding]; other site 1052588002735 Citrate synthase; Region: Citrate_synt; pfam00285 1052588002736 active site 1052588002737 citrylCoA binding site [chemical binding]; other site 1052588002738 oxalacetate/citrate binding site [chemical binding]; other site 1052588002739 coenzyme A binding site [chemical binding]; other site 1052588002740 catalytic triad [active] 1052588002741 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588002742 NAD(P) binding site [chemical binding]; other site 1052588002743 active site 1052588002744 amino acid transporter; Region: 2A0306; TIGR00909 1052588002745 Spore germination protein; Region: Spore_permease; cl15802 1052588002746 Spore germination protein; Region: Spore_permease; cl15802 1052588002747 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1052588002748 Na2 binding site [ion binding]; other site 1052588002749 putative substrate binding site 1 [chemical binding]; other site 1052588002750 Na binding site 1 [ion binding]; other site 1052588002751 putative substrate binding site 2 [chemical binding]; other site 1052588002752 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1052588002753 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588002754 DNA-binding site [nucleotide binding]; DNA binding site 1052588002755 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052588002756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588002757 homodimer interface [polypeptide binding]; other site 1052588002758 catalytic residue [active] 1052588002759 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1052588002760 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588002761 Coenzyme A binding pocket [chemical binding]; other site 1052588002762 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 1052588002763 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 1052588002764 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 1052588002765 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052588002766 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588002767 DNA binding residues [nucleotide binding] 1052588002768 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1052588002769 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052588002770 active site 1052588002771 catalytic tetrad [active] 1052588002772 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1052588002773 putative acyl-acceptor binding pocket; other site 1052588002774 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1052588002775 Domain of unknown function DUF21; Region: DUF21; pfam01595 1052588002776 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1052588002777 Transporter associated domain; Region: CorC_HlyC; cl08393 1052588002778 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 1052588002779 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1052588002780 DNA binding residues [nucleotide binding] 1052588002781 putative dimer interface [polypeptide binding]; other site 1052588002782 aspartate aminotransferase; Provisional; Region: PRK06836 1052588002783 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052588002784 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588002785 homodimer interface [polypeptide binding]; other site 1052588002786 catalytic residue [active] 1052588002787 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1052588002788 Domain of unknown function DUF21; Region: DUF21; pfam01595 1052588002789 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1052588002790 Transporter associated domain; Region: CorC_HlyC; cl08393 1052588002791 CrcB-like protein; Region: CRCB; cl09114 1052588002792 CrcB-like protein; Region: CRCB; cl09114 1052588002793 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1052588002794 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1052588002795 active site 1052588002796 catalytic site [active] 1052588002797 metal binding site [ion binding]; metal-binding site 1052588002798 dimer interface [polypeptide binding]; other site 1052588002799 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1052588002800 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1052588002801 NAD-dependent deacetylase; Provisional; Region: PRK00481 1052588002802 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1052588002803 NAD+ binding site [chemical binding]; other site 1052588002804 substrate binding site [chemical binding]; other site 1052588002805 Zn binding site [ion binding]; other site 1052588002806 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1052588002807 NodB motif; other site 1052588002808 active site 1052588002809 catalytic site [active] 1052588002810 Zn binding site [ion binding]; other site 1052588002811 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1052588002812 homodimer interface [polypeptide binding]; other site 1052588002813 substrate-cofactor binding pocket; other site 1052588002814 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588002815 catalytic residue [active] 1052588002816 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1052588002817 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1052588002818 Ligand Binding Site [chemical binding]; other site 1052588002819 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1052588002820 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1052588002821 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588002822 Walker A/P-loop; other site 1052588002823 ATP binding site [chemical binding]; other site 1052588002824 Q-loop/lid; other site 1052588002825 ABC transporter signature motif; other site 1052588002826 Walker B; other site 1052588002827 D-loop; other site 1052588002828 H-loop/switch region; other site 1052588002829 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052588002830 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1052588002831 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 1052588002832 Walker A/P-loop; other site 1052588002833 ATP binding site [chemical binding]; other site 1052588002834 Q-loop/lid; other site 1052588002835 ABC transporter signature motif; other site 1052588002836 Walker B; other site 1052588002837 D-loop; other site 1052588002838 H-loop/switch region; other site 1052588002839 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1052588002840 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1052588002841 NAD binding site [chemical binding]; other site 1052588002842 substrate binding site [chemical binding]; other site 1052588002843 putative active site [active] 1052588002844 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1052588002845 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1052588002846 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1052588002847 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1052588002848 Protein of unknown function (DUF964); Region: DUF964; cl01483 1052588002849 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1052588002850 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588002851 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1052588002852 active site 1052588002853 motif I; other site 1052588002854 motif II; other site 1052588002855 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1052588002856 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 1052588002857 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052588002858 FeS/SAM binding site; other site 1052588002859 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1052588002860 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1052588002861 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1052588002862 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1052588002863 enoyl-CoA hydratase; Provisional; Region: PRK07659 1052588002864 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1052588002865 substrate binding site [chemical binding]; other site 1052588002866 oxyanion hole (OAH) forming residues; other site 1052588002867 trimer interface [polypeptide binding]; other site 1052588002868 YhzD-like protein; Region: YhzD; pfam14120 1052588002869 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1052588002870 This subfamily is involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity. In eubacteria and archaea, the typical organization consists of one ABC and one or two IMs. Eukaryote systems of the ABCA subfamily...; Region: ABC_putative_ATPase; cd03269 1052588002871 Walker A/P-loop; other site 1052588002872 ATP binding site [chemical binding]; other site 1052588002873 Q-loop/lid; other site 1052588002874 ABC transporter signature motif; other site 1052588002875 Walker B; other site 1052588002876 D-loop; other site 1052588002877 H-loop/switch region; other site 1052588002878 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1052588002879 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1052588002880 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1052588002881 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1052588002882 active site 1052588002883 metal binding site [ion binding]; metal-binding site 1052588002884 DNA binding site [nucleotide binding] 1052588002885 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1052588002886 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588002887 Q-loop/lid; other site 1052588002888 ABC transporter signature motif; other site 1052588002889 Walker B; other site 1052588002890 D-loop; other site 1052588002891 H-loop/switch region; other site 1052588002892 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1052588002893 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 1052588002894 generic binding surface II; other site 1052588002895 generic binding surface I; other site 1052588002896 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052588002897 Zn2+ binding site [ion binding]; other site 1052588002898 Mg2+ binding site [ion binding]; other site 1052588002899 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 1052588002900 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1052588002901 PPIC-type PPIASE domain; Region: Rotamase; cl08278 1052588002902 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1052588002903 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 1052588002904 transcriptional regulator Hpr; Provisional; Region: PRK13777 1052588002905 Helix-turn-helix domains; Region: HTH; cl00088 1052588002906 YtxH-like protein; Region: YtxH; cl02079 1052588002907 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1052588002908 homodimer interface [polypeptide binding]; other site 1052588002909 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1052588002910 substrate-cofactor binding pocket; other site 1052588002911 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588002912 catalytic residue [active] 1052588002913 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1052588002914 HIT family signature motif; other site 1052588002915 catalytic residue [active] 1052588002916 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1052588002917 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1052588002918 Walker A/P-loop; other site 1052588002919 ATP binding site [chemical binding]; other site 1052588002920 Q-loop/lid; other site 1052588002921 ABC transporter signature motif; other site 1052588002922 Walker B; other site 1052588002923 D-loop; other site 1052588002924 H-loop/switch region; other site 1052588002925 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 1052588002926 EcsC protein family; Region: EcsC; pfam12787 1052588002927 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1052588002928 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1052588002929 metal binding site [ion binding]; metal-binding site 1052588002930 dimer interface [polypeptide binding]; other site 1052588002931 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 1052588002932 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1052588002933 Transglycosylase; Region: Transgly; cl07896 1052588002934 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1052588002935 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052588002936 methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463 1052588002937 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1052588002938 substrate binding site [chemical binding]; other site 1052588002939 active site 1052588002940 ferrochelatase; Provisional; Region: PRK12435 1052588002941 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1052588002942 C-terminal domain interface [polypeptide binding]; other site 1052588002943 active site 1052588002944 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1052588002945 active site 1052588002946 N-terminal domain interface [polypeptide binding]; other site 1052588002947 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1052588002948 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588002949 SEA domain; Region: SEA; cl02507 1052588002950 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052588002951 Helix-turn-helix domains; Region: HTH; cl00088 1052588002952 Predicted membrane protein [Function unknown]; Region: COG1511 1052588002953 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1052588002954 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1052588002955 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 1052588002956 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1052588002957 dimer interface [polypeptide binding]; other site 1052588002958 active site 1052588002959 CoA binding pocket [chemical binding]; other site 1052588002960 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 1052588002961 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1052588002962 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1052588002963 putative oligomer interface [polypeptide binding]; other site 1052588002964 putative active site [active] 1052588002965 metal binding site [ion binding]; metal-binding site 1052588002966 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 1052588002967 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1052588002968 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1052588002969 YhfH-like protein; Region: YhfH; pfam14149 1052588002970 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052588002971 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1052588002972 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1052588002973 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1052588002974 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1052588002975 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1052588002976 NAD(P) binding site [chemical binding]; other site 1052588002977 putative active site [active] 1052588002978 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1052588002979 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588002980 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052588002981 Peptidase family M48; Region: Peptidase_M48; cl12018 1052588002982 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1052588002983 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1052588002984 active site 1052588002985 catalytic residues [active] 1052588002986 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1052588002987 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588002988 Coenzyme A binding pocket [chemical binding]; other site 1052588002989 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 1052588002990 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1052588002991 putative NADP binding site [chemical binding]; other site 1052588002992 putative dimer interface [polypeptide binding]; other site 1052588002993 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1052588002994 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1052588002995 siderophore binding site; other site 1052588002996 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1052588002997 catalytic core [active] 1052588002998 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 1052588002999 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1052588003000 dimer interface [polypeptide binding]; other site 1052588003001 active site 1052588003002 acyl-CoA synthetase; Validated; Region: PRK07638 1052588003003 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588003004 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052588003005 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 1052588003006 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 1052588003007 heme-binding site [chemical binding]; other site 1052588003008 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052588003009 dimer interface [polypeptide binding]; other site 1052588003010 putative CheW interface [polypeptide binding]; other site 1052588003011 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1052588003012 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 1052588003013 [2Fe-2S] cluster binding site [ion binding]; other site 1052588003014 short chain dehydrogenase; Provisional; Region: PRK06701 1052588003015 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1052588003016 NAD binding site [chemical binding]; other site 1052588003017 metal binding site [ion binding]; metal-binding site 1052588003018 active site 1052588003019 IDEAL domain; Region: IDEAL; cl07452 1052588003020 ComK protein; Region: ComK; cl11560 1052588003021 oxidoreductase; Provisional; Region: PRK07985 1052588003022 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1052588003023 NAD binding site [chemical binding]; other site 1052588003024 metal binding site [ion binding]; metal-binding site 1052588003025 active site 1052588003026 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1052588003027 Na binding site [ion binding]; other site 1052588003028 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1052588003029 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1052588003030 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1052588003031 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1052588003032 Catalytic site [active] 1052588003033 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588003034 hypothetical protein; Provisional; Region: PRK08244 1052588003035 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588003036 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588003037 Helix-turn-helix domains; Region: HTH; cl00088 1052588003038 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1052588003039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588003040 putative substrate translocation pore; other site 1052588003041 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588003042 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052588003043 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1052588003044 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1052588003045 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588003046 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1052588003047 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1052588003048 inhibitor-cofactor binding pocket; inhibition site 1052588003049 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588003050 catalytic residue [active] 1052588003051 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052588003052 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052588003053 DNA binding site [nucleotide binding] 1052588003054 domain linker motif; other site 1052588003055 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1052588003056 putative dimerization interface [polypeptide binding]; other site 1052588003057 putative ligand binding site [chemical binding]; other site 1052588003058 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1052588003059 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1052588003060 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1052588003061 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588003062 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588003063 putative substrate translocation pore; other site 1052588003064 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1052588003065 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1052588003066 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1052588003067 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1052588003068 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 1052588003069 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1052588003070 dinuclear metal binding motif [ion binding]; other site 1052588003071 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1052588003072 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1052588003073 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1052588003074 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588003075 Family description; Region: UvrD_C_2; cl15862 1052588003076 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1052588003077 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1052588003078 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1052588003079 active site 1052588003080 metal binding site [ion binding]; metal-binding site 1052588003081 DNA binding site [nucleotide binding] 1052588003082 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1052588003083 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1052588003084 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 1052588003085 Walker A/P-loop; other site 1052588003086 ATP binding site [chemical binding]; other site 1052588003087 Q-loop/lid; other site 1052588003088 ABC transporter signature motif; other site 1052588003089 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 1052588003090 ABC transporter signature motif; other site 1052588003091 Walker B; other site 1052588003092 D-loop; other site 1052588003093 H-loop/switch region; other site 1052588003094 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1052588003095 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1052588003096 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1052588003097 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1052588003098 Spore germination protein GerPC; Region: GerPC; pfam10737 1052588003099 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 1052588003100 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1052588003101 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1052588003102 CotH protein; Region: CotH; pfam08757 1052588003103 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1052588003104 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1052588003105 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 1052588003106 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1052588003107 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 1052588003108 active site 1052588003109 catalytic triad [active] 1052588003110 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 1052588003111 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1052588003112 active site 1052588003113 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1052588003114 dimer interface [polypeptide binding]; other site 1052588003115 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1052588003116 Ligand Binding Site [chemical binding]; other site 1052588003117 Molecular Tunnel; other site 1052588003118 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1052588003119 substrate binding pocket [chemical binding]; other site 1052588003120 aspartate-rich region 2; other site 1052588003121 substrate-Mg2+ binding site; other site 1052588003122 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1052588003123 MatE; Region: MatE; cl10513 1052588003124 MatE; Region: MatE; cl10513 1052588003125 Cupin domain; Region: Cupin_2; cl09118 1052588003126 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052588003127 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052588003128 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052588003129 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052588003130 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052588003131 DNA binding site [nucleotide binding] 1052588003132 domain linker motif; other site 1052588003133 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1052588003134 dimerization interface [polypeptide binding]; other site 1052588003135 ligand binding site [chemical binding]; other site 1052588003136 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1052588003137 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1052588003138 LysE type translocator; Region: LysE; cl00565 1052588003139 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052588003140 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588003141 homodimer interface [polypeptide binding]; other site 1052588003142 catalytic residue [active] 1052588003143 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1052588003144 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1052588003145 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1052588003146 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052588003147 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052588003148 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 1052588003149 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 1052588003150 ligand-binding site [chemical binding]; other site 1052588003151 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1052588003152 ATP-sulfurylase; Region: ATPS; cd00517 1052588003153 active site 1052588003154 HXXH motif; other site 1052588003155 flexible loop; other site 1052588003156 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1052588003157 Active Sites [active] 1052588003158 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 1052588003159 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 1052588003160 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782 1052588003161 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1052588003162 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052588003163 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1052588003164 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1052588003165 active site pocket [active] 1052588003166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588003167 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588003168 putative substrate translocation pore; other site 1052588003169 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1052588003170 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052588003171 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052588003172 Protein of unknown function (DUF520); Region: DUF520; cl00723 1052588003173 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1052588003174 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1052588003175 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1052588003176 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 1052588003177 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052588003178 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052588003179 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 1052588003180 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 1052588003181 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 1052588003182 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1052588003183 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588003184 motif II; other site 1052588003185 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588003186 esterase; Provisional; Region: PRK10566 1052588003187 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052588003188 Domain of unknown function DUF59; Region: DUF59; cl00941 1052588003189 Proteolipid membrane potential modulator; Region: Pmp3; cl00431 1052588003190 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1052588003191 FAD binding domain; Region: FAD_binding_4; pfam01565 1052588003192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588003193 putative substrate translocation pore; other site 1052588003194 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 1052588003195 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588003196 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1052588003197 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1052588003198 heterotetramer interface [polypeptide binding]; other site 1052588003199 active site pocket [active] 1052588003200 cleavage site 1052588003201 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1052588003202 nucleotide binding site [chemical binding]; other site 1052588003203 N-acetyl-L-glutamate binding site [chemical binding]; other site 1052588003204 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 1052588003205 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052588003206 inhibitor-cofactor binding pocket; inhibition site 1052588003207 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588003208 catalytic residue [active] 1052588003209 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 1052588003210 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 1052588003211 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1052588003212 catalytic site [active] 1052588003213 subunit interface [polypeptide binding]; other site 1052588003214 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 1052588003215 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052588003216 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1052588003217 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1052588003218 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052588003219 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1052588003220 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1052588003221 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1052588003222 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588003223 YjzC-like protein; Region: YjzC; pfam14168 1052588003224 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1052588003225 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1052588003226 UDP-apiose/xylose synthase; Region: PLN02427 1052588003227 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1052588003228 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1052588003229 putative ligand binding site [chemical binding]; other site 1052588003230 ComZ; Region: ComZ; pfam10815 1052588003231 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1052588003232 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1052588003233 dimer interface [polypeptide binding]; other site 1052588003234 active site 1052588003235 CoA binding pocket [chemical binding]; other site 1052588003236 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1052588003237 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1052588003238 dimer interface [polypeptide binding]; other site 1052588003239 active site 1052588003240 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 1052588003241 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1052588003242 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1052588003243 Walker A/P-loop; other site 1052588003244 ATP binding site [chemical binding]; other site 1052588003245 Q-loop/lid; other site 1052588003246 ABC transporter signature motif; other site 1052588003247 Walker B; other site 1052588003248 D-loop; other site 1052588003249 H-loop/switch region; other site 1052588003250 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1052588003251 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1052588003252 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1052588003253 Walker A/P-loop; other site 1052588003254 ATP binding site [chemical binding]; other site 1052588003255 Q-loop/lid; other site 1052588003256 ABC transporter signature motif; other site 1052588003257 Walker B; other site 1052588003258 D-loop; other site 1052588003259 H-loop/switch region; other site 1052588003260 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1052588003261 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 1052588003262 peptide binding site [polypeptide binding]; other site 1052588003263 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1052588003264 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1052588003265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588003266 dimer interface [polypeptide binding]; other site 1052588003267 conserved gate region; other site 1052588003268 putative PBP binding loops; other site 1052588003269 ABC-ATPase subunit interface; other site 1052588003270 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1052588003271 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1052588003272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588003273 dimer interface [polypeptide binding]; other site 1052588003274 conserved gate region; other site 1052588003275 putative PBP binding loops; other site 1052588003276 ABC-ATPase subunit interface; other site 1052588003277 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 1052588003278 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1052588003279 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1052588003280 active site 1052588003281 HIGH motif; other site 1052588003282 dimer interface [polypeptide binding]; other site 1052588003283 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1052588003284 KMSKS motif; other site 1052588003285 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1052588003286 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1052588003287 peptide binding site [polypeptide binding]; other site 1052588003288 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1052588003289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588003290 dimer interface [polypeptide binding]; other site 1052588003291 conserved gate region; other site 1052588003292 putative PBP binding loops; other site 1052588003293 ABC-ATPase subunit interface; other site 1052588003294 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1052588003295 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1052588003296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588003297 dimer interface [polypeptide binding]; other site 1052588003298 conserved gate region; other site 1052588003299 putative PBP binding loops; other site 1052588003300 ABC-ATPase subunit interface; other site 1052588003301 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1052588003302 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1052588003303 Walker A/P-loop; other site 1052588003304 ATP binding site [chemical binding]; other site 1052588003305 Q-loop/lid; other site 1052588003306 ABC transporter signature motif; other site 1052588003307 Walker B; other site 1052588003308 D-loop; other site 1052588003309 H-loop/switch region; other site 1052588003310 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1052588003311 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1052588003312 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1052588003313 Walker A/P-loop; other site 1052588003314 ATP binding site [chemical binding]; other site 1052588003315 Q-loop/lid; other site 1052588003316 ABC transporter signature motif; other site 1052588003317 Walker B; other site 1052588003318 D-loop; other site 1052588003319 H-loop/switch region; other site 1052588003320 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1052588003321 H+ Antiporter protein; Region: 2A0121; TIGR00900 1052588003322 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1052588003323 ArsC family; Region: ArsC; pfam03960 1052588003324 putative catalytic residues [active] 1052588003325 thiol/disulfide switch; other site 1052588003326 Integral membrane protein TerC family; Region: TerC; cl10468 1052588003327 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 1052588003328 Competence protein CoiA-like family; Region: CoiA; cl11541 1052588003329 oligoendopeptidase F; Region: pepF; TIGR00181 1052588003330 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1052588003331 active site 1052588003332 Zn binding site [ion binding]; other site 1052588003333 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1052588003334 Thioredoxin; Region: Thioredoxin_5; pfam13743 1052588003335 catalytic residues [active] 1052588003336 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1052588003337 apolar tunnel; other site 1052588003338 heme binding site [chemical binding]; other site 1052588003339 dimerization interface [polypeptide binding]; other site 1052588003340 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1052588003341 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1052588003342 catalytic residue [active] 1052588003343 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1052588003344 putative active site [active] 1052588003345 putative metal binding residues [ion binding]; other site 1052588003346 signature motif; other site 1052588003347 putative triphosphate binding site [ion binding]; other site 1052588003348 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1052588003349 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1052588003350 synthetase active site [active] 1052588003351 NTP binding site [chemical binding]; other site 1052588003352 metal binding site [ion binding]; metal-binding site 1052588003353 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1052588003354 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1052588003355 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1052588003356 active site 1052588003357 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 1052588003358 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 1052588003359 active site 1052588003360 metal binding site [ion binding]; metal-binding site 1052588003361 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1052588003362 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1052588003363 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1052588003364 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588003365 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1052588003366 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 1052588003367 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1052588003368 thiamine phosphate binding site [chemical binding]; other site 1052588003369 active site 1052588003370 pyrophosphate binding site [ion binding]; other site 1052588003371 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1052588003372 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588003373 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1052588003374 thiS-thiF/thiG interaction site; other site 1052588003375 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1052588003376 ThiS interaction site; other site 1052588003377 putative active site [active] 1052588003378 tetramer interface [polypeptide binding]; other site 1052588003379 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1052588003380 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1052588003381 ATP binding site [chemical binding]; other site 1052588003382 substrate interface [chemical binding]; other site 1052588003383 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1052588003384 dimer interface [polypeptide binding]; other site 1052588003385 substrate binding site [chemical binding]; other site 1052588003386 ATP binding site [chemical binding]; other site 1052588003387 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 1052588003388 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1052588003389 NAD binding site [chemical binding]; other site 1052588003390 homotetramer interface [polypeptide binding]; other site 1052588003391 homodimer interface [polypeptide binding]; other site 1052588003392 substrate binding site [chemical binding]; other site 1052588003393 active site 1052588003394 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 1052588003395 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1052588003396 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1052588003397 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1052588003398 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1052588003399 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1052588003400 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1052588003401 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 1052588003402 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1052588003403 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588003404 Family description; Region: UvrD_C_2; cl15862 1052588003405 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052588003406 hypothetical protein; Provisional; Region: PRK13679 1052588003407 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1052588003408 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052588003409 Putative esterase; Region: Esterase; pfam00756 1052588003410 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1052588003411 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1052588003412 homodimer interface [polypeptide binding]; other site 1052588003413 substrate-cofactor binding pocket; other site 1052588003414 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588003415 catalytic residue [active] 1052588003416 cystathionine beta-lyase; Provisional; Region: PRK08064 1052588003417 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1052588003418 homodimer interface [polypeptide binding]; other site 1052588003419 substrate-cofactor binding pocket; other site 1052588003420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588003421 catalytic residue [active] 1052588003422 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052588003423 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052588003424 Peptidase family M48; Region: Peptidase_M48; cl12018 1052588003425 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1052588003426 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1052588003427 Holin family; Region: Phage_holin_4; cl01989 1052588003428 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1052588003429 amidase catalytic site [active] 1052588003430 Zn binding residues [ion binding]; other site 1052588003431 substrate binding site [chemical binding]; other site 1052588003432 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1052588003433 YolD-like protein; Region: YolD; pfam08863 1052588003434 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1052588003435 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1052588003436 Helix-turn-helix domains; Region: HTH; cl00088 1052588003437 Helix-turn-helix domains; Region: HTH; cl00088 1052588003438 PRD domain; Region: PRD; cl15445 1052588003439 PRD domain; Region: PRD; cl15445 1052588003440 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1052588003441 active site 1052588003442 P-loop; other site 1052588003443 phosphorylation site [posttranslational modification] 1052588003444 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1052588003445 active site 1052588003446 phosphorylation site [posttranslational modification] 1052588003447 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1052588003448 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1052588003449 active site 1052588003450 P-loop; other site 1052588003451 phosphorylation site [posttranslational modification] 1052588003452 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1052588003453 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1052588003454 active site 1052588003455 phosphorylation site [posttranslational modification] 1052588003456 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1052588003457 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 1052588003458 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 1052588003459 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052588003460 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052588003461 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1052588003462 putative deacylase active site [active] 1052588003463 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1052588003464 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 1052588003465 UbiA prenyltransferase family; Region: UbiA; cl00337 1052588003466 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1052588003467 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1052588003468 Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947 1052588003469 NodB motif; other site 1052588003470 active site 1052588003471 catalytic site [active] 1052588003472 Zn binding site [ion binding]; other site 1052588003473 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 1052588003474 Putative motility protein; Region: YjfB_motility; pfam14070 1052588003475 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 1052588003476 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 1052588003477 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 1052588003478 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1052588003479 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1052588003480 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 1052588003481 4Fe-4S binding domain; Region: Fer4; cl02805 1052588003482 4Fe-4S binding domain; Region: Fer4; cl02805 1052588003483 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1052588003484 [4Fe-4S] binding site [ion binding]; other site 1052588003485 molybdopterin cofactor binding site; other site 1052588003486 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1052588003487 molybdopterin cofactor binding site; other site 1052588003488 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 1052588003489 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1052588003490 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1052588003491 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1052588003492 nudix motif; other site 1052588003493 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1052588003494 Cytochrome P450; Region: p450; pfam00067 1052588003495 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1052588003496 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1052588003497 active site 1052588003498 TDP-binding site; other site 1052588003499 acceptor substrate-binding pocket; other site 1052588003500 homodimer interface [polypeptide binding]; other site 1052588003501 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1052588003502 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1052588003503 active site 1052588003504 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 1052588003505 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1052588003506 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 1052588003507 Walker A/P-loop; other site 1052588003508 ATP binding site [chemical binding]; other site 1052588003509 Q-loop/lid; other site 1052588003510 ABC transporter signature motif; other site 1052588003511 Walker B; other site 1052588003512 D-loop; other site 1052588003513 H-loop/switch region; other site 1052588003514 EamA-like transporter family; Region: EamA; cl01037 1052588003515 Cupin domain; Region: Cupin_2; cl09118 1052588003516 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 1052588003517 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1052588003518 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052588003519 Glucuronate isomerase; Region: UxaC; cl00829 1052588003520 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1052588003521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588003522 putative substrate translocation pore; other site 1052588003523 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1052588003524 putative oxidoreductase; Provisional; Region: PRK10083 1052588003525 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1052588003526 putative NAD(P) binding site [chemical binding]; other site 1052588003527 catalytic Zn binding site [ion binding]; other site 1052588003528 structural Zn binding site [ion binding]; other site 1052588003529 mannonate dehydratase; Provisional; Region: PRK03906 1052588003530 mannonate dehydratase; Region: uxuA; TIGR00695 1052588003531 D-mannonate oxidoreductase; Provisional; Region: PRK08277 1052588003532 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 1052588003533 putative NAD(P) binding site [chemical binding]; other site 1052588003534 active site 1052588003535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588003536 D-galactonate transporter; Region: 2A0114; TIGR00893 1052588003537 putative substrate translocation pore; other site 1052588003538 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052588003539 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052588003540 DNA binding site [nucleotide binding] 1052588003541 domain linker motif; other site 1052588003542 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1052588003543 dimerization interface [polypeptide binding]; other site 1052588003544 ligand binding site [chemical binding]; other site 1052588003545 altronate oxidoreductase; Provisional; Region: PRK03643 1052588003546 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1052588003547 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1052588003548 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1052588003549 Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721 1052588003550 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1052588003551 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 1052588003552 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1052588003553 DinB superfamily; Region: DinB_2; pfam12867 1052588003554 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 1052588003555 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588003556 Walker A motif; other site 1052588003557 ATP binding site [chemical binding]; other site 1052588003558 Walker B motif; other site 1052588003559 arginine finger; other site 1052588003560 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052588003561 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1052588003562 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1052588003563 YCII-related domain; Region: YCII; cl00999 1052588003564 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1052588003565 amidase catalytic site [active] 1052588003566 Zn binding residues [ion binding]; other site 1052588003567 substrate binding site [chemical binding]; other site 1052588003568 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588003569 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1052588003570 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 1052588003571 Protein of unknown function (DUF867); Region: DUF867; cl01713 1052588003572 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1052588003573 dimanganese center [ion binding]; other site 1052588003574 Domain of unknown function (DUF955); Region: DUF955; cl01076 1052588003575 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052588003576 non-specific DNA binding site [nucleotide binding]; other site 1052588003577 salt bridge; other site 1052588003578 sequence-specific DNA binding site [nucleotide binding]; other site 1052588003579 DNA replication protein DnaC; Validated; Region: PRK07952 1052588003580 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1052588003581 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588003582 Walker A motif; other site 1052588003583 ATP binding site [chemical binding]; other site 1052588003584 Walker B motif; other site 1052588003585 positive control sigma-like factor; Validated; Region: PRK06930 1052588003586 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588003587 DNA binding residues [nucleotide binding] 1052588003588 Phage terminase small subunit; Region: Phage_terminase; pfam10668 1052588003589 Terminase small subunit; Region: Terminase_2; cl01513 1052588003590 Phage terminase large subunit; Region: Terminase_3; cl12054 1052588003591 Terminase-like family; Region: Terminase_6; pfam03237 1052588003592 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1052588003593 phage portal protein, PBSX family; Region: portal_PBSX; TIGR01540 1052588003594 Phage capsid family; Region: Phage_capsid; pfam05065 1052588003595 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 1052588003596 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 1052588003597 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1052588003598 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 1052588003599 Phage XkdN-like protein; Region: XkdN; pfam08890 1052588003600 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1052588003601 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1052588003602 catalytic residue [active] 1052588003603 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1052588003604 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588003605 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1052588003606 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 1052588003607 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 1052588003608 Baseplate J-like protein; Region: Baseplate_J; cl01294 1052588003609 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 1052588003610 XkdW protein; Region: XkdW; pfam09636 1052588003611 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 1052588003612 Haemolysin XhlA; Region: XhlA; pfam10779 1052588003613 Phage lysis protein, holin; Region: Phage_holin; cl04675 1052588003614 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1052588003615 amidase catalytic site [active] 1052588003616 Zn binding residues [ion binding]; other site 1052588003617 substrate binding site [chemical binding]; other site 1052588003618 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588003619 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1052588003620 Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185 1052588003621 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 1052588003622 Phosphate transporter family; Region: PHO4; cl00396 1052588003623 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1052588003624 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 1052588003625 Spore germination protein; Region: Spore_permease; cl15802 1052588003626 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1052588003627 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052588003628 Zn binding site [ion binding]; other site 1052588003629 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1052588003630 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052588003631 Zn binding site [ion binding]; other site 1052588003632 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 1052588003633 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1052588003634 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1052588003635 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1052588003636 Ligand binding site; other site 1052588003637 Putative Catalytic site; other site 1052588003638 DXD motif; other site 1052588003639 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1052588003640 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1052588003641 protein binding site [polypeptide binding]; other site 1052588003642 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588003643 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1052588003644 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cd00281 1052588003645 SxDxEG motif; other site 1052588003646 active site 1052588003647 metal binding site [ion binding]; metal-binding site 1052588003648 homopentamer interface [polypeptide binding]; other site 1052588003649 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1052588003650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588003651 dimer interface [polypeptide binding]; other site 1052588003652 conserved gate region; other site 1052588003653 putative PBP binding loops; other site 1052588003654 ABC-ATPase subunit interface; other site 1052588003655 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1052588003656 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1052588003657 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588003658 dimer interface [polypeptide binding]; other site 1052588003659 conserved gate region; other site 1052588003660 putative PBP binding loops; other site 1052588003661 ABC-ATPase subunit interface; other site 1052588003662 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1052588003663 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1052588003664 Walker A/P-loop; other site 1052588003665 ATP binding site [chemical binding]; other site 1052588003666 Q-loop/lid; other site 1052588003667 ABC transporter signature motif; other site 1052588003668 Walker B; other site 1052588003669 D-loop; other site 1052588003670 H-loop/switch region; other site 1052588003671 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1052588003672 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1052588003673 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1052588003674 peptide binding site [polypeptide binding]; other site 1052588003675 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1052588003676 dimer interface [polypeptide binding]; other site 1052588003677 catalytic triad [active] 1052588003678 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1052588003679 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1052588003680 active site 1052588003681 NlpC/P60 family; Region: NLPC_P60; cl11438 1052588003682 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1052588003683 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1052588003684 Walker A/P-loop; other site 1052588003685 ATP binding site [chemical binding]; other site 1052588003686 Q-loop/lid; other site 1052588003687 ABC transporter signature motif; other site 1052588003688 Walker B; other site 1052588003689 D-loop; other site 1052588003690 H-loop/switch region; other site 1052588003691 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1052588003692 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1052588003693 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1052588003694 Amidinotransferase; Region: Amidinotransf; cl12043 1052588003695 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1052588003696 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1052588003697 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1052588003698 heme-binding site [chemical binding]; other site 1052588003699 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1052588003700 FAD binding pocket [chemical binding]; other site 1052588003701 FAD binding motif [chemical binding]; other site 1052588003702 phosphate binding motif [ion binding]; other site 1052588003703 beta-alpha-beta structure motif; other site 1052588003704 NAD binding pocket [chemical binding]; other site 1052588003705 Heme binding pocket [chemical binding]; other site 1052588003706 Protein of unknown function (DUF421); Region: DUF421; cl00990 1052588003707 DinB superfamily; Region: DinB_2; pfam12867 1052588003708 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1052588003709 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1052588003710 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052588003711 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1052588003712 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1052588003713 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1052588003714 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1052588003715 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1052588003716 putative active site [active] 1052588003717 putative substrate binding site [chemical binding]; other site 1052588003718 putative cosubstrate binding site; other site 1052588003719 catalytic site [active] 1052588003720 glutamate 5-kinase; Region: proB; TIGR01027 1052588003721 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1052588003722 nucleotide binding site [chemical binding]; other site 1052588003723 homotetrameric interface [polypeptide binding]; other site 1052588003724 putative phosphate binding site [ion binding]; other site 1052588003725 putative allosteric binding site; other site 1052588003726 PUA domain; Region: PUA; cl00607 1052588003727 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1052588003728 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1052588003729 putative catalytic cysteine [active] 1052588003730 OsmC-like protein; Region: OsmC; cl00767 1052588003731 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1052588003732 Helix-turn-helix domains; Region: HTH; cl00088 1052588003733 OsmC-like protein; Region: OsmC; cl00767 1052588003734 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1052588003735 nucleoside/Zn binding site; other site 1052588003736 dimer interface [polypeptide binding]; other site 1052588003737 catalytic motif [active] 1052588003738 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1052588003739 catalytic core [active] 1052588003740 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1052588003741 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Region: met_syn_B12ind; TIGR01371 1052588003742 THF binding site; other site 1052588003743 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1052588003744 substrate binding site [chemical binding]; other site 1052588003745 THF binding site; other site 1052588003746 zinc-binding site [ion binding]; other site 1052588003747 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1052588003748 active site 1052588003749 catalytic residues [active] 1052588003750 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1052588003751 Cobalt transport protein; Region: CbiQ; cl00463 1052588003752 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1052588003753 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 1052588003754 Walker A/P-loop; other site 1052588003755 ATP binding site [chemical binding]; other site 1052588003756 Q-loop/lid; other site 1052588003757 ABC transporter signature motif; other site 1052588003758 Walker B; other site 1052588003759 D-loop; other site 1052588003760 H-loop/switch region; other site 1052588003761 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 1052588003762 Walker A/P-loop; other site 1052588003763 ATP binding site [chemical binding]; other site 1052588003764 Q-loop/lid; other site 1052588003765 ABC transporter signature motif; other site 1052588003766 Walker B; other site 1052588003767 D-loop; other site 1052588003768 H-loop/switch region; other site 1052588003769 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1052588003770 YKOF-related Family; Region: Ykof; pfam07615 1052588003771 YKOF-related Family; Region: Ykof; pfam07615 1052588003772 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052588003773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588003774 active site 1052588003775 phosphorylation site [posttranslational modification] 1052588003776 intermolecular recognition site; other site 1052588003777 dimerization interface [polypeptide binding]; other site 1052588003778 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052588003779 DNA binding site [nucleotide binding] 1052588003780 Predicted membrane protein [Function unknown]; Region: COG3212 1052588003781 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 1052588003782 Predicted membrane protein [Function unknown]; Region: COG3212 1052588003783 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 1052588003784 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1052588003785 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 1052588003786 MgtE intracellular N domain; Region: MgtE_N; cl15244 1052588003787 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1052588003788 Divalent cation transporter; Region: MgtE; cl00786 1052588003789 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1052588003790 DNA binding residues [nucleotide binding] 1052588003791 putative dimer interface [polypeptide binding]; other site 1052588003792 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588003793 Helix-turn-helix domains; Region: HTH; cl00088 1052588003794 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 1052588003795 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1052588003796 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 1052588003797 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1052588003798 putative active site [active] 1052588003799 putative metal binding site [ion binding]; other site 1052588003800 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 1052588003801 RNA polymerase beta'' subunit; Reviewed; Region: rpoC2; CHL00117 1052588003802 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1052588003803 Ligand binding site; other site 1052588003804 Putative Catalytic site; other site 1052588003805 DXD motif; other site 1052588003806 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 1052588003807 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1052588003808 active site 1052588003809 DNA binding site [nucleotide binding] 1052588003810 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 1052588003811 nucleotide binding site [chemical binding]; other site 1052588003812 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1052588003813 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1052588003814 putative DNA binding site [nucleotide binding]; other site 1052588003815 putative homodimer interface [polypeptide binding]; other site 1052588003816 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1052588003817 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1052588003818 PAS domain; Region: PAS_9; pfam13426 1052588003819 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1052588003820 metal binding site [ion binding]; metal-binding site 1052588003821 active site 1052588003822 I-site; other site 1052588003823 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1052588003824 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1052588003825 Integral membrane protein TerC family; Region: TerC; cl10468 1052588003826 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 1052588003827 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052588003828 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 1052588003829 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1052588003830 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1052588003831 Peptidase family M48; Region: Peptidase_M48; cl12018 1052588003832 Cation transport protein; Region: TrkH; cl10514 1052588003833 OpgC protein; Region: OpgC_C; cl00792 1052588003834 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1052588003835 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1052588003836 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1052588003837 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1052588003838 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1052588003839 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1052588003840 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1052588003841 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1052588003842 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052588003843 dimer interface [polypeptide binding]; other site 1052588003844 phosphorylation site [posttranslational modification] 1052588003845 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588003846 ATP binding site [chemical binding]; other site 1052588003847 Mg2+ binding site [ion binding]; other site 1052588003848 G-X-G motif; other site 1052588003849 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1052588003850 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1052588003851 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1052588003852 DNA binding site [nucleotide binding] 1052588003853 active site 1052588003854 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1052588003855 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 1052588003856 Phosphotransferase enzyme family; Region: APH; pfam01636 1052588003857 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052588003858 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1052588003859 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1052588003860 putative active site [active] 1052588003861 catalytic triad [active] 1052588003862 putative dimer interface [polypeptide binding]; other site 1052588003863 transaminase; Reviewed; Region: PRK08068 1052588003864 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052588003865 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588003866 homodimer interface [polypeptide binding]; other site 1052588003867 catalytic residue [active] 1052588003868 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: salvage_mtnW; TIGR03332 1052588003869 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 1052588003870 dimer interface [polypeptide binding]; other site 1052588003871 active site 1052588003872 catalytic residue [active] 1052588003873 metal binding site [ion binding]; metal-binding site 1052588003874 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588003875 motif II; other site 1052588003876 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1052588003877 intersubunit interface [polypeptide binding]; other site 1052588003878 active site 1052588003879 Zn2+ binding site [ion binding]; other site 1052588003880 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1052588003881 Cupin domain; Region: Cupin_2; cl09118 1052588003882 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 1052588003883 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1052588003884 Cache domain; Region: Cache_1; pfam02743 1052588003885 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1052588003886 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052588003887 dimer interface [polypeptide binding]; other site 1052588003888 phosphorylation site [posttranslational modification] 1052588003889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588003890 ATP binding site [chemical binding]; other site 1052588003891 Mg2+ binding site [ion binding]; other site 1052588003892 G-X-G motif; other site 1052588003893 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588003894 Helix-turn-helix domains; Region: HTH; cl00088 1052588003895 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 1052588003896 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1052588003897 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1052588003898 ligand binding site [chemical binding]; other site 1052588003899 flagellar motor protein MotA; Validated; Region: PRK08124 1052588003900 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1052588003901 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588003902 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1052588003903 Walker A motif; other site 1052588003904 ATP binding site [chemical binding]; other site 1052588003905 Walker B motif; other site 1052588003906 arginine finger; other site 1052588003907 UvrB/uvrC motif; Region: UVR; pfam02151 1052588003908 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588003909 Walker A motif; other site 1052588003910 ATP binding site [chemical binding]; other site 1052588003911 Walker B motif; other site 1052588003912 arginine finger; other site 1052588003913 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1052588003914 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1052588003915 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1052588003916 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1052588003917 Ligand Binding Site [chemical binding]; other site 1052588003918 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1052588003919 active site 1052588003920 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1052588003921 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052588003922 FeS/SAM binding site; other site 1052588003923 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1052588003924 Helix-turn-helix domains; Region: HTH; cl00088 1052588003925 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1052588003926 classical (c) SDRs; Region: SDR_c; cd05233 1052588003927 NAD(P) binding site [chemical binding]; other site 1052588003928 active site 1052588003929 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588003930 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1052588003931 active site 1052588003932 Protein of unknown function (DUF3219); Region: DUF3219; pfam11514 1052588003933 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 1052588003934 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1052588003935 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1052588003936 MatE; Region: MatE; cl10513 1052588003937 MatE; Region: MatE; cl10513 1052588003938 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1052588003939 catalytic residues [active] 1052588003940 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1052588003941 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1052588003942 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1052588003943 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1052588003944 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1052588003945 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1052588003946 active site 1052588003947 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052588003948 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052588003949 DNA binding site [nucleotide binding] 1052588003950 domain linker motif; other site 1052588003951 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1052588003952 putative dimerization interface [polypeptide binding]; other site 1052588003953 putative ligand binding site [chemical binding]; other site 1052588003954 CAT RNA binding domain; Region: CAT_RBD; cl03904 1052588003955 PRD domain; Region: PRD; cl15445 1052588003956 PRD domain; Region: PRD; cl15445 1052588003957 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1052588003958 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1052588003959 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052588003960 active site turn [active] 1052588003961 phosphorylation site [posttranslational modification] 1052588003962 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1052588003963 HPr interaction site; other site 1052588003964 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1052588003965 active site 1052588003966 phosphorylation site [posttranslational modification] 1052588003967 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1052588003968 dimerization domain swap beta strand [polypeptide binding]; other site 1052588003969 regulatory protein interface [polypeptide binding]; other site 1052588003970 active site 1052588003971 regulatory phosphorylation site [posttranslational modification]; other site 1052588003972 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 1052588003973 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1052588003974 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1052588003975 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 1052588003976 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1052588003977 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1052588003978 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052588003979 FeS/SAM binding site; other site 1052588003980 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052588003981 Cache domain; Region: Cache_1; pfam02743 1052588003982 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052588003983 dimerization interface [polypeptide binding]; other site 1052588003984 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052588003985 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052588003986 dimer interface [polypeptide binding]; other site 1052588003987 putative CheW interface [polypeptide binding]; other site 1052588003988 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588003989 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1052588003990 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1052588003991 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1052588003992 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1052588003993 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1052588003994 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052588003995 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052588003996 putative active site [active] 1052588003997 heme pocket [chemical binding]; other site 1052588003998 PAS fold; Region: PAS; pfam00989 1052588003999 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052588004000 putative active site [active] 1052588004001 heme pocket [chemical binding]; other site 1052588004002 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1052588004003 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1052588004004 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052588004005 dimer interface [polypeptide binding]; other site 1052588004006 phosphorylation site [posttranslational modification] 1052588004007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588004008 ATP binding site [chemical binding]; other site 1052588004009 Mg2+ binding site [ion binding]; other site 1052588004010 G-X-G motif; other site 1052588004011 aminotransferase A; Validated; Region: PRK07683 1052588004012 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052588004013 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588004014 homodimer interface [polypeptide binding]; other site 1052588004015 catalytic residue [active] 1052588004016 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1052588004017 putative CheA interaction surface; other site 1052588004018 Response regulator receiver domain; Region: Response_reg; pfam00072 1052588004019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588004020 active site 1052588004021 phosphorylation site [posttranslational modification] 1052588004022 intermolecular recognition site; other site 1052588004023 dimerization interface [polypeptide binding]; other site 1052588004024 YkyB-like protein; Region: YkyB; pfam14177 1052588004025 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588004026 H+ Antiporter protein; Region: 2A0121; TIGR00900 1052588004027 putative substrate translocation pore; other site 1052588004028 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588004029 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 1052588004030 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 1052588004031 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1052588004032 putative active site [active] 1052588004033 putative metal binding site [ion binding]; other site 1052588004034 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1052588004035 short chain dehydrogenase; Provisional; Region: PRK07677 1052588004036 NAD(P) binding site [chemical binding]; other site 1052588004037 substrate binding site [chemical binding]; other site 1052588004038 homotetramer interface [polypeptide binding]; other site 1052588004039 active site 1052588004040 homodimer interface [polypeptide binding]; other site 1052588004041 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1052588004042 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 1052588004043 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 1052588004044 Protein of unknown function (DUF458); Region: DUF458; cl00861 1052588004045 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 1052588004046 FOG: CBS domain [General function prediction only]; Region: COG0517 1052588004047 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1052588004048 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052588004049 Helix-turn-helix domains; Region: HTH; cl00088 1052588004050 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052588004051 dimerization interface [polypeptide binding]; other site 1052588004052 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1052588004053 BNR repeat-like domain; Region: BNR_2; pfam13088 1052588004054 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1052588004055 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1052588004056 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1052588004057 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1052588004058 active site 1052588004059 trimer interface [polypeptide binding]; other site 1052588004060 substrate binding site [chemical binding]; other site 1052588004061 CoA binding site [chemical binding]; other site 1052588004062 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1052588004063 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1052588004064 metal binding site [ion binding]; metal-binding site 1052588004065 putative dimer interface [polypeptide binding]; other site 1052588004066 Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214 1052588004067 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1052588004068 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1052588004069 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1052588004070 dimer interface [polypeptide binding]; other site 1052588004071 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1052588004072 catalytic triad [active] 1052588004073 peroxidatic and resolving cysteines [active] 1052588004074 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1052588004075 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 1052588004076 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1052588004077 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1052588004078 GTP binding site; other site 1052588004079 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 1052588004080 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1052588004081 ATP binding site [chemical binding]; other site 1052588004082 substrate interface [chemical binding]; other site 1052588004083 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1052588004084 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1052588004085 dimer interface [polypeptide binding]; other site 1052588004086 putative functional site; other site 1052588004087 putative MPT binding site; other site 1052588004088 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1052588004089 Walker A motif; other site 1052588004090 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1052588004091 MoaE homodimer interface [polypeptide binding]; other site 1052588004092 MoaD interaction [polypeptide binding]; other site 1052588004093 active site residues [active] 1052588004094 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1052588004095 MoaE interaction surface [polypeptide binding]; other site 1052588004096 MoeB interaction surface [polypeptide binding]; other site 1052588004097 thiocarboxylated glycine; other site 1052588004098 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052588004099 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1052588004100 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 1052588004101 Walker A/P-loop; other site 1052588004102 ATP binding site [chemical binding]; other site 1052588004103 Q-loop/lid; other site 1052588004104 ABC transporter signature motif; other site 1052588004105 Walker B; other site 1052588004106 D-loop; other site 1052588004107 H-loop/switch region; other site 1052588004108 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052588004109 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1052588004110 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 1052588004111 Walker A/P-loop; other site 1052588004112 ATP binding site [chemical binding]; other site 1052588004113 Q-loop/lid; other site 1052588004114 ABC transporter signature motif; other site 1052588004115 Walker B; other site 1052588004116 D-loop; other site 1052588004117 H-loop/switch region; other site 1052588004118 Yip1 domain; Region: Yip1; cl12048 1052588004119 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1052588004120 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1052588004121 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1052588004122 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052588004123 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1052588004124 Walker A/P-loop; other site 1052588004125 ATP binding site [chemical binding]; other site 1052588004126 Q-loop/lid; other site 1052588004127 ABC transporter signature motif; other site 1052588004128 Walker B; other site 1052588004129 D-loop; other site 1052588004130 H-loop/switch region; other site 1052588004131 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1052588004132 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1052588004133 FtsX-like permease family; Region: FtsX; cl15850 1052588004134 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1052588004135 Helix-turn-helix domains; Region: HTH; cl00088 1052588004136 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1052588004137 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1052588004138 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1052588004139 putative substrate binding site [chemical binding]; other site 1052588004140 putative ATP binding site [chemical binding]; other site 1052588004141 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1052588004142 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1052588004143 active site 1052588004144 phosphorylation site [posttranslational modification] 1052588004145 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1052588004146 active site 1052588004147 P-loop; other site 1052588004148 phosphorylation site [posttranslational modification] 1052588004149 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1052588004150 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1052588004151 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1052588004152 Catalytic site [active] 1052588004153 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1052588004154 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1052588004155 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1052588004156 ABC transporter; Region: ABC_tran_2; pfam12848 1052588004157 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1052588004158 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1052588004159 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588004160 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1052588004161 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1052588004162 rod-share determining protein MreBH; Provisional; Region: PRK13929 1052588004163 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 1052588004164 ATP binding site [chemical binding]; other site 1052588004165 profilin binding site; other site 1052588004166 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1052588004167 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1052588004168 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052588004169 putative active site [active] 1052588004170 heme pocket [chemical binding]; other site 1052588004171 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052588004172 dimer interface [polypeptide binding]; other site 1052588004173 phosphorylation site [posttranslational modification] 1052588004174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588004175 ATP binding site [chemical binding]; other site 1052588004176 Mg2+ binding site [ion binding]; other site 1052588004177 G-X-G motif; other site 1052588004178 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1052588004179 putative active site pocket [active] 1052588004180 dimerization interface [polypeptide binding]; other site 1052588004181 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1052588004182 putative active site pocket [active] 1052588004183 dimerization interface [polypeptide binding]; other site 1052588004184 putative catalytic residue [active] 1052588004185 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1052588004186 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588004187 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1052588004188 adenine deaminase; Region: ade; TIGR01178 1052588004189 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1052588004190 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1052588004191 active site 1052588004192 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1052588004193 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1052588004194 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052588004195 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1052588004196 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 1052588004197 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588004198 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1052588004199 active site 1052588004200 motif I; other site 1052588004201 motif II; other site 1052588004202 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1052588004203 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1052588004204 active site 1052588004205 catalytic residues [active] 1052588004206 metal binding site [ion binding]; metal-binding site 1052588004207 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1052588004208 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1052588004209 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1052588004210 TPP-binding site [chemical binding]; other site 1052588004211 tetramer interface [polypeptide binding]; other site 1052588004212 heterodimer interface [polypeptide binding]; other site 1052588004213 phosphorylation loop region [posttranslational modification] 1052588004214 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1052588004215 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1052588004216 alpha subunit interface [polypeptide binding]; other site 1052588004217 TPP binding site [chemical binding]; other site 1052588004218 heterodimer interface [polypeptide binding]; other site 1052588004219 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1052588004220 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1052588004221 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1052588004222 E3 interaction surface; other site 1052588004223 lipoyl attachment site [posttranslational modification]; other site 1052588004224 e3 binding domain; Region: E3_binding; pfam02817 1052588004225 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 1052588004226 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1052588004227 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588004228 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052588004229 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1052588004230 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 1052588004231 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1052588004232 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1052588004233 homodimer interface [polypeptide binding]; other site 1052588004234 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588004235 catalytic residue [active] 1052588004236 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1052588004237 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 1052588004238 Protein of unknown function (DUF1054); Region: DUF1054; cl11544 1052588004239 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1052588004240 active site 1052588004241 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1052588004242 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1052588004243 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1052588004244 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 1052588004245 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1052588004246 active site 1052588004247 Zn binding site [ion binding]; other site 1052588004248 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052588004249 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 1052588004250 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588004251 DNA binding residues [nucleotide binding] 1052588004252 Predicted integral membrane protein [Function unknown]; Region: COG5660 1052588004253 Putative zinc-finger; Region: zf-HC2; cl15806 1052588004254 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1052588004255 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1052588004256 G1 box; other site 1052588004257 putative GEF interaction site [polypeptide binding]; other site 1052588004258 GTP/Mg2+ binding site [chemical binding]; other site 1052588004259 Switch I region; other site 1052588004260 G2 box; other site 1052588004261 G3 box; other site 1052588004262 Switch II region; other site 1052588004263 G4 box; other site 1052588004264 G5 box; other site 1052588004265 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1052588004266 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1052588004267 YlaH-like protein; Region: YlaH; pfam14036 1052588004268 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; cl11558 1052588004269 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1052588004270 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1052588004271 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1052588004272 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1052588004273 putative active site [active] 1052588004274 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588004275 Glutaminase; Region: Glutaminase; cl00907 1052588004276 Protein of unknown function (DUF1507); Region: DUF1507; cl11487 1052588004277 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1052588004278 pyruvate carboxylase; Reviewed; Region: PRK12999 1052588004279 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052588004280 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1052588004281 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1052588004282 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1052588004283 active site 1052588004284 catalytic residues [active] 1052588004285 metal binding site [ion binding]; metal-binding site 1052588004286 homodimer binding site [polypeptide binding]; other site 1052588004287 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1052588004288 carboxyltransferase (CT) interaction site; other site 1052588004289 biotinylation site [posttranslational modification]; other site 1052588004290 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1052588004291 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 1052588004292 UbiA prenyltransferase family; Region: UbiA; cl00337 1052588004293 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1052588004294 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1052588004295 Cytochrome c; Region: Cytochrom_C; cl11414 1052588004296 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1052588004297 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1052588004298 D-pathway; other site 1052588004299 Putative ubiquinol binding site [chemical binding]; other site 1052588004300 Low-spin heme (heme b) binding site [chemical binding]; other site 1052588004301 Putative water exit pathway; other site 1052588004302 Binuclear center (heme o3/CuB) [ion binding]; other site 1052588004303 K-pathway; other site 1052588004304 Putative proton exit pathway; other site 1052588004305 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1052588004306 Subunit I/III interface [polypeptide binding]; other site 1052588004307 Subunit III/IV interface [polypeptide binding]; other site 1052588004308 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 1052588004309 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 1052588004310 YugN-like family; Region: YugN; pfam08868 1052588004311 FOG: CBS domain [General function prediction only]; Region: COG0517 1052588004312 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1052588004313 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1052588004314 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1052588004315 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1052588004316 Putative coat protein; Region: YlbD_coat; pfam14071 1052588004317 YlbE-like protein; Region: YlbE; pfam14003 1052588004318 Protein of unknown function (DUF964); Region: DUF964; cl01483 1052588004319 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 1052588004320 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588004321 S-adenosylmethionine binding site [chemical binding]; other site 1052588004322 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1052588004323 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1052588004324 active site 1052588004325 (T/H)XGH motif; other site 1052588004326 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 1052588004327 Nucleoside recognition; Region: Gate; cl00486 1052588004328 Nucleoside recognition; Region: Gate; cl00486 1052588004329 hypothetical protein; Provisional; Region: PRK10279 1052588004330 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1052588004331 nucleophile elbow; other site 1052588004332 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1052588004333 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1052588004334 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 1052588004335 protein binding site [polypeptide binding]; other site 1052588004336 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1052588004337 hypothetical protein; Provisional; Region: PRK13670 1052588004338 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1052588004339 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1052588004340 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1052588004341 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1052588004342 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588004343 Coenzyme A binding pocket [chemical binding]; other site 1052588004344 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1052588004345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588004346 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1052588004347 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1052588004348 mraZ protein; Region: TIGR00242 1052588004349 MraZ protein; Region: MraZ; pfam02381 1052588004350 MraZ protein; Region: MraZ; pfam02381 1052588004351 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1052588004352 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1052588004353 Septum formation initiator; Region: DivIC; cl11433 1052588004354 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1052588004355 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1052588004356 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052588004357 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1052588004358 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1052588004359 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 1052588004360 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1052588004361 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052588004362 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 1052588004363 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1052588004364 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1052588004365 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1052588004366 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1052588004367 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 1052588004368 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1052588004369 Mg++ binding site [ion binding]; other site 1052588004370 putative catalytic motif [active] 1052588004371 putative substrate binding site [chemical binding]; other site 1052588004372 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1052588004373 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1052588004374 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1052588004375 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1052588004376 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1052588004377 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1052588004378 active site 1052588004379 homodimer interface [polypeptide binding]; other site 1052588004380 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1052588004381 FAD binding domain; Region: FAD_binding_4; pfam01565 1052588004382 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1052588004383 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1052588004384 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1052588004385 Cell division protein FtsQ; Region: FtsQ; pfam03799 1052588004386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1052588004387 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1052588004388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1052588004389 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1052588004390 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 1052588004391 cell division protein FtsA; Region: ftsA; TIGR01174 1052588004392 Cell division protein FtsA; Region: FtsA; cl11496 1052588004393 Cell division protein FtsA; Region: FtsA; cl11496 1052588004394 cell division protein FtsZ; Validated; Region: PRK09330 1052588004395 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1052588004396 nucleotide binding site [chemical binding]; other site 1052588004397 SulA interaction site; other site 1052588004398 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1052588004399 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 1052588004400 active site 1052588004401 catalytic triad [active] 1052588004402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 1052588004403 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1052588004404 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1052588004405 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1052588004406 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 1052588004407 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 1052588004408 sporulation sigma factor SigE; Reviewed; Region: PRK08301 1052588004409 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052588004410 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588004411 DNA binding residues [nucleotide binding] 1052588004412 sporulation sigma factor SigG; Reviewed; Region: PRK08215 1052588004413 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052588004414 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1052588004415 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588004416 DNA binding residues [nucleotide binding] 1052588004417 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1052588004418 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588004419 Walker A/P-loop; other site 1052588004420 ATP binding site [chemical binding]; other site 1052588004421 Q-loop/lid; other site 1052588004422 ABC transporter signature motif; other site 1052588004423 Walker B; other site 1052588004424 D-loop; other site 1052588004425 H-loop/switch region; other site 1052588004426 acetylornithine deacetylase; Validated; Region: PRK08596 1052588004427 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1052588004428 metal binding site [ion binding]; metal-binding site 1052588004429 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 1052588004430 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1052588004431 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1052588004432 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1052588004433 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1052588004434 catalytic residue [active] 1052588004435 Protein of unknown function (DUF552); Region: DUF552; cl00775 1052588004436 YGGT family; Region: YGGT; cl00508 1052588004437 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1052588004438 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052588004439 RNA binding surface [nucleotide binding]; other site 1052588004440 DivIVA protein; Region: DivIVA; pfam05103 1052588004441 DivIVA domain; Region: DivI1A_domain; TIGR03544 1052588004442 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1052588004443 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1052588004444 lipoprotein signal peptidase; Provisional; Region: PRK14787 1052588004445 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1052588004446 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052588004447 RNA binding surface [nucleotide binding]; other site 1052588004448 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1052588004449 active site 1052588004450 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052588004451 active site 1052588004452 uracil-xanthine permease; Region: ncs2; TIGR00801 1052588004453 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1052588004454 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1052588004455 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588004456 dihydroorotase; Validated; Region: pyrC; PRK09357 1052588004457 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1052588004458 active site 1052588004459 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1052588004460 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 1052588004461 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1052588004462 catalytic site [active] 1052588004463 subunit interface [polypeptide binding]; other site 1052588004464 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1052588004465 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052588004466 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1052588004467 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1052588004468 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052588004469 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1052588004470 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1052588004471 IMP binding site; other site 1052588004472 dimer interface [polypeptide binding]; other site 1052588004473 interdomain contacts; other site 1052588004474 partial ornithine binding site; other site 1052588004475 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1052588004476 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1052588004477 FAD binding pocket [chemical binding]; other site 1052588004478 FAD binding motif [chemical binding]; other site 1052588004479 phosphate binding motif [ion binding]; other site 1052588004480 beta-alpha-beta structure motif; other site 1052588004481 NAD binding pocket [chemical binding]; other site 1052588004482 Iron coordination center [ion binding]; other site 1052588004483 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1052588004484 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1052588004485 heterodimer interface [polypeptide binding]; other site 1052588004486 active site 1052588004487 FMN binding site [chemical binding]; other site 1052588004488 homodimer interface [polypeptide binding]; other site 1052588004489 substrate binding site [chemical binding]; other site 1052588004490 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 1052588004491 active site 1052588004492 dimer interface [polypeptide binding]; other site 1052588004493 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052588004494 active site 1052588004495 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1052588004496 Active Sites [active] 1052588004497 Phosphate transporter family; Region: PHO4; cl00396 1052588004498 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1052588004499 ATP-sulfurylase; Region: ATPS; cd00517 1052588004500 active site 1052588004501 HXXH motif; other site 1052588004502 flexible loop; other site 1052588004503 AAA domain; Region: AAA_33; pfam13671 1052588004504 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 1052588004505 ligand-binding site [chemical binding]; other site 1052588004506 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1052588004507 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 1052588004508 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1052588004509 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1052588004510 putative active site [active] 1052588004511 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1052588004512 putative active site [active] 1052588004513 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588004514 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1052588004515 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1052588004516 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1052588004517 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 1052588004518 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1052588004519 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1052588004520 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588004521 motif II; other site 1052588004522 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1052588004523 TIGR00255 family protein; Region: TIGR00255 1052588004524 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1052588004525 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1052588004526 Domain of unknown function (DUF370); Region: DUF370; cl00898 1052588004527 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1052588004528 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1052588004529 catalytic site [active] 1052588004530 G-X2-G-X-G-K; other site 1052588004531 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 1052588004532 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 1052588004533 primosome assembly protein PriA; Validated; Region: PRK05580 1052588004534 primosome assembly protein PriA; Validated; Region: PRK05580 1052588004535 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052588004536 ATP binding site [chemical binding]; other site 1052588004537 putative Mg++ binding site [ion binding]; other site 1052588004538 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052588004539 nucleotide binding region [chemical binding]; other site 1052588004540 ATP-binding site [chemical binding]; other site 1052588004541 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1052588004542 active site 1052588004543 catalytic residues [active] 1052588004544 metal binding site [ion binding]; metal-binding site 1052588004545 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1052588004546 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1052588004547 putative active site [active] 1052588004548 substrate binding site [chemical binding]; other site 1052588004549 putative cosubstrate binding site; other site 1052588004550 catalytic site [active] 1052588004551 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1052588004552 substrate binding site [chemical binding]; other site 1052588004553 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1052588004554 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1052588004555 putative RNA binding site [nucleotide binding]; other site 1052588004556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588004557 S-adenosylmethionine binding site [chemical binding]; other site 1052588004558 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1052588004559 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052588004560 FeS/SAM binding site; other site 1052588004561 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1052588004562 Protein phosphatase 2C; Region: PP2C; pfam00481 1052588004563 active site 1052588004564 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052588004565 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1052588004566 active site 1052588004567 ATP binding site [chemical binding]; other site 1052588004568 substrate binding site [chemical binding]; other site 1052588004569 activation loop (A-loop); other site 1052588004570 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1052588004571 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1052588004572 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1052588004573 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1052588004574 GTPase RsgA; Reviewed; Region: PRK00098 1052588004575 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1052588004576 RNA binding site [nucleotide binding]; other site 1052588004577 homodimer interface [polypeptide binding]; other site 1052588004578 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1052588004579 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1052588004580 GTP/Mg2+ binding site [chemical binding]; other site 1052588004581 G4 box; other site 1052588004582 G5 box; other site 1052588004583 G1 box; other site 1052588004584 Switch I region; other site 1052588004585 G2 box; other site 1052588004586 G3 box; other site 1052588004587 Switch II region; other site 1052588004588 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1052588004589 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1052588004590 substrate binding site [chemical binding]; other site 1052588004591 hexamer interface [polypeptide binding]; other site 1052588004592 metal binding site [ion binding]; metal-binding site 1052588004593 Thiamine pyrophosphokinase; Region: TPK; cd07995 1052588004594 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1052588004595 active site 1052588004596 dimerization interface [polypeptide binding]; other site 1052588004597 thiamine binding site [chemical binding]; other site 1052588004598 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 1052588004599 Asp23 family; Region: Asp23; cl00574 1052588004600 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1052588004601 DAK2 domain; Region: Dak2; cl03685 1052588004602 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 1052588004603 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1052588004604 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1052588004605 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 1052588004606 putative L-serine binding site [chemical binding]; other site 1052588004607 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1052588004608 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1052588004609 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1052588004610 TfoX N-terminal domain; Region: TfoX_N; cl01167 1052588004611 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1052588004612 generic binding surface II; other site 1052588004613 ssDNA binding site; other site 1052588004614 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052588004615 ATP binding site [chemical binding]; other site 1052588004616 putative Mg++ binding site [ion binding]; other site 1052588004617 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052588004618 nucleotide binding region [chemical binding]; other site 1052588004619 ATP-binding site [chemical binding]; other site 1052588004620 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1052588004621 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1052588004622 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 1052588004623 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1052588004624 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1052588004625 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1052588004626 NAD(P) binding site [chemical binding]; other site 1052588004627 homotetramer interface [polypeptide binding]; other site 1052588004628 homodimer interface [polypeptide binding]; other site 1052588004629 active site 1052588004630 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588004631 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 1052588004632 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1052588004633 dimerization interface [polypeptide binding]; other site 1052588004634 active site 1052588004635 metal binding site [ion binding]; metal-binding site 1052588004636 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1052588004637 dsRNA binding site [nucleotide binding]; other site 1052588004638 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1052588004639 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 1052588004640 Walker A/P-loop; other site 1052588004641 ATP binding site [chemical binding]; other site 1052588004642 Q-loop/lid; other site 1052588004643 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 1052588004644 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 1052588004645 ABC transporter signature motif; other site 1052588004646 Walker B; other site 1052588004647 D-loop; other site 1052588004648 H-loop/switch region; other site 1052588004649 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1052588004650 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 1052588004651 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1052588004652 GTP binding site [chemical binding]; other site 1052588004653 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1052588004654 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1052588004655 signal recognition particle protein; Provisional; Region: PRK10867 1052588004656 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 1052588004657 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1052588004658 P loop; other site 1052588004659 GTP binding site [chemical binding]; other site 1052588004660 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1052588004661 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 1052588004662 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1052588004663 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 1052588004664 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 1052588004665 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1052588004666 RimM N-terminal domain; Region: RimM; pfam01782 1052588004667 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 1052588004668 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 1052588004669 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 1052588004670 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1052588004671 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1052588004672 GTP/Mg2+ binding site [chemical binding]; other site 1052588004673 G4 box; other site 1052588004674 G5 box; other site 1052588004675 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1052588004676 G1 box; other site 1052588004677 G1 box; other site 1052588004678 GTP/Mg2+ binding site [chemical binding]; other site 1052588004679 Switch I region; other site 1052588004680 G2 box; other site 1052588004681 G2 box; other site 1052588004682 G3 box; other site 1052588004683 G3 box; other site 1052588004684 Switch II region; other site 1052588004685 Switch II region; other site 1052588004686 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1052588004687 RNA/DNA hybrid binding site [nucleotide binding]; other site 1052588004688 active site 1052588004689 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1052588004690 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1052588004691 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1052588004692 CoA-ligase; Region: Ligase_CoA; cl02894 1052588004693 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1052588004694 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588004695 CoA-ligase; Region: Ligase_CoA; cl02894 1052588004696 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1052588004697 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1052588004698 DNA topoisomerase I; Validated; Region: PRK05582 1052588004699 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1052588004700 active site 1052588004701 interdomain interaction site; other site 1052588004702 putative metal-binding site [ion binding]; other site 1052588004703 nucleotide binding site [chemical binding]; other site 1052588004704 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1052588004705 domain I; other site 1052588004706 DNA binding groove [nucleotide binding] 1052588004707 phosphate binding site [ion binding]; other site 1052588004708 domain II; other site 1052588004709 domain III; other site 1052588004710 nucleotide binding site [chemical binding]; other site 1052588004711 catalytic site [active] 1052588004712 domain IV; other site 1052588004713 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1052588004714 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1052588004715 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1052588004716 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588004717 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1052588004718 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1052588004719 active site 1052588004720 Int/Topo IB signature motif; other site 1052588004721 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1052588004722 active site 1052588004723 HslU subunit interaction site [polypeptide binding]; other site 1052588004724 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1052588004725 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588004726 Walker A motif; other site 1052588004727 ATP binding site [chemical binding]; other site 1052588004728 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588004729 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1052588004730 transcriptional repressor CodY; Validated; Region: PRK04158 1052588004731 CodY GAF-like domain; Region: CodY; pfam06018 1052588004732 Helix-turn-helix domains; Region: HTH; cl00088 1052588004733 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1052588004734 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 1052588004735 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 1052588004736 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1052588004737 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 1052588004738 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1052588004739 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 1052588004740 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 1052588004741 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1052588004742 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1052588004743 flagellar motor switch protein FliG; Region: fliG; TIGR00207 1052588004744 MgtE intracellular N domain; Region: MgtE_N; cl15244 1052588004745 FliG C-terminal domain; Region: FliG_C; pfam01706 1052588004746 flagellar assembly protein H; Validated; Region: fliH; PRK06669 1052588004747 Flagellar assembly protein FliH; Region: FliH; pfam02108 1052588004748 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 1052588004749 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 1052588004750 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1052588004751 Walker A motif/ATP binding site; other site 1052588004752 Walker B motif; other site 1052588004753 flagellar biosynthesis chaperone; Validated; Region: fliJ; cl09161 1052588004754 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 1052588004755 MgtE intracellular N domain; Region: MgtE_N; cl15244 1052588004756 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 1052588004757 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 1052588004758 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 1052588004759 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1052588004760 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 1052588004761 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 1052588004762 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1052588004763 Flagellar protein (FlbD); Region: FlbD; cl00683 1052588004764 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 1052588004765 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1052588004766 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1052588004767 flagellar motor switch protein; Validated; Region: PRK08119 1052588004768 Chemotaxis phosphatase CheX; Region: CheX; cl15816 1052588004769 Chemotaxis phosphatase CheX; Region: CheX; cl15816 1052588004770 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1052588004771 Response regulator receiver domain; Region: Response_reg; pfam00072 1052588004772 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588004773 active site 1052588004774 phosphorylation site [posttranslational modification] 1052588004775 intermolecular recognition site; other site 1052588004776 dimerization interface [polypeptide binding]; other site 1052588004777 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 1052588004778 FliP family; Region: FliP; cl00593 1052588004779 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 1052588004780 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 1052588004781 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1052588004782 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1052588004783 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 1052588004784 FHIPEP family; Region: FHIPEP; pfam00771 1052588004785 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1052588004786 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588004787 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1052588004788 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1052588004789 P-loop; other site 1052588004790 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1052588004791 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1052588004792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588004793 active site 1052588004794 phosphorylation site [posttranslational modification] 1052588004795 intermolecular recognition site; other site 1052588004796 dimerization interface [polypeptide binding]; other site 1052588004797 CheB methylesterase; Region: CheB_methylest; pfam01339 1052588004798 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1052588004799 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1052588004800 putative binding surface; other site 1052588004801 active site 1052588004802 P2 response regulator binding domain; Region: P2; pfam07194 1052588004803 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1052588004804 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588004805 ATP binding site [chemical binding]; other site 1052588004806 Mg2+ binding site [ion binding]; other site 1052588004807 G-X-G motif; other site 1052588004808 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1052588004809 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1052588004810 putative CheA interaction surface; other site 1052588004811 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1052588004812 Chemotaxis phosphatase CheX; Region: CheX; cl15816 1052588004813 Chemotaxis phosphatase CheX; Region: CheX; cl15816 1052588004814 CheD chemotactic sensory transduction; Region: CheD; cl00810 1052588004815 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 1052588004816 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052588004817 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1052588004818 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588004819 DNA binding residues [nucleotide binding] 1052588004820 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1052588004821 rRNA interaction site [nucleotide binding]; other site 1052588004822 S8 interaction site; other site 1052588004823 putative laminin-1 binding site; other site 1052588004824 elongation factor Ts; Provisional; Region: tsf; PRK09377 1052588004825 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 1052588004826 Elongation factor TS; Region: EF_TS; pfam00889 1052588004827 Elongation factor TS; Region: EF_TS; pfam00889 1052588004828 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1052588004829 putative nucleotide binding site [chemical binding]; other site 1052588004830 uridine monophosphate binding site [chemical binding]; other site 1052588004831 homohexameric interface [polypeptide binding]; other site 1052588004832 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1052588004833 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 1052588004834 hinge region; other site 1052588004835 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1052588004836 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1052588004837 catalytic residue [active] 1052588004838 putative FPP diphosphate binding site; other site 1052588004839 putative FPP binding hydrophobic cleft; other site 1052588004840 dimer interface [polypeptide binding]; other site 1052588004841 putative IPP diphosphate binding site; other site 1052588004842 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 1052588004843 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1052588004844 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1052588004845 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1052588004846 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1052588004847 RIP metalloprotease RseP; Region: TIGR00054 1052588004848 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1052588004849 active site 1052588004850 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1052588004851 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1052588004852 protein binding site [polypeptide binding]; other site 1052588004853 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1052588004854 putative substrate binding region [chemical binding]; other site 1052588004855 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 1052588004856 motif 3; other site 1052588004857 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1052588004858 anticodon binding site; other site 1052588004859 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1052588004860 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1052588004861 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1052588004862 generic binding surface II; other site 1052588004863 generic binding surface I; other site 1052588004864 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1052588004865 active site 1052588004866 catalytic site [active] 1052588004867 substrate binding site [chemical binding]; other site 1052588004868 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 1052588004869 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1052588004870 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 1052588004871 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 1052588004872 Sm1 motif; other site 1052588004873 predicted subunit interaction site [polypeptide binding]; other site 1052588004874 RNA binding pocket [nucleotide binding]; other site 1052588004875 Sm2 motif; other site 1052588004876 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1052588004877 NusA N-terminal domain; Region: NusA_N; pfam08529 1052588004878 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1052588004879 RNA binding site [nucleotide binding]; other site 1052588004880 homodimer interface [polypeptide binding]; other site 1052588004881 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 1052588004882 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1052588004883 G-X-X-G motif; other site 1052588004884 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1052588004885 putative RNA binding cleft [nucleotide binding]; other site 1052588004886 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1052588004887 Translation-initiation factor 2; Region: IF-2; pfam11987 1052588004888 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1052588004889 Protein of unknown function (DUF503); Region: DUF503; cl00669 1052588004890 Ribosome-binding factor A; Region: RBFA; cl00542 1052588004891 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1052588004892 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1052588004893 RNA binding site [nucleotide binding]; other site 1052588004894 active site 1052588004895 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1052588004896 riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083 1052588004897 active site 1052588004898 Riboflavin kinase; Region: Flavokinase; cl03312 1052588004899 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1052588004900 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1052588004901 RNase E interface [polypeptide binding]; other site 1052588004902 trimer interface [polypeptide binding]; other site 1052588004903 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1052588004904 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1052588004905 RNase E interface [polypeptide binding]; other site 1052588004906 trimer interface [polypeptide binding]; other site 1052588004907 active site 1052588004908 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1052588004909 putative nucleic acid binding region [nucleotide binding]; other site 1052588004910 G-X-X-G motif; other site 1052588004911 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1052588004912 RNA binding site [nucleotide binding]; other site 1052588004913 domain interface; other site 1052588004914 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 1052588004915 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 1052588004916 NodB motif; other site 1052588004917 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1052588004918 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1052588004919 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1052588004920 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 1052588004921 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 1052588004922 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588004923 Flavoprotein; Region: Flavoprotein; cl08021 1052588004924 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1052588004925 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588004926 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1052588004927 aspartate kinase I; Reviewed; Region: PRK08210 1052588004928 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1052588004929 nucleotide binding site [chemical binding]; other site 1052588004930 substrate binding site [chemical binding]; other site 1052588004931 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 1052588004932 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 1052588004933 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1052588004934 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1052588004935 dimer interface [polypeptide binding]; other site 1052588004936 active site 1052588004937 catalytic residue [active] 1052588004938 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1052588004939 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052588004940 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1052588004941 Clp protease; Region: CLP_protease; pfam00574 1052588004942 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1052588004943 active site 1052588004944 YlzJ-like protein; Region: YlzJ; pfam14035 1052588004945 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1052588004946 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1052588004947 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588004948 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 1052588004949 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1052588004950 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588004951 DNA-binding site [nucleotide binding]; DNA binding site 1052588004952 UTRA domain; Region: UTRA; cl01230 1052588004953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588004954 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588004955 putative substrate translocation pore; other site 1052588004956 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1052588004957 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1052588004958 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1052588004959 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1052588004960 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1052588004961 classical (c) SDRs; Region: SDR_c; cd05233 1052588004962 NAD(P) binding site [chemical binding]; other site 1052588004963 active site 1052588004964 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1052588004965 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1052588004966 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1052588004967 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1052588004968 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1052588004969 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1052588004970 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1052588004971 competence damage-inducible protein A; Provisional; Region: PRK00549 1052588004972 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1052588004973 putative MPT binding site; other site 1052588004974 Competence-damaged protein; Region: CinA; cl00666 1052588004975 recombinase A; Provisional; Region: recA; PRK09354 1052588004976 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1052588004977 hexamer interface [polypeptide binding]; other site 1052588004978 Walker A motif; other site 1052588004979 ATP binding site [chemical binding]; other site 1052588004980 Walker B motif; other site 1052588004981 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052588004982 phosphodiesterase; Provisional; Region: PRK12704 1052588004983 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1052588004984 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1052588004985 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1052588004986 putative active site [active] 1052588004987 metal binding site [ion binding]; metal-binding site 1052588004988 homodimer binding site [polypeptide binding]; other site 1052588004989 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 1052588004990 Threonine dehydrogenase; Region: TDH; cd05281 1052588004991 L-threonine 3-dehydrogenase; Region: tdh; TIGR00692 1052588004992 structural Zn binding site [ion binding]; other site 1052588004993 catalytic Zn binding site [ion binding]; other site 1052588004994 tetramer interface [polypeptide binding]; other site 1052588004995 NADP binding site [chemical binding]; other site 1052588004996 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1052588004997 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1052588004998 substrate-cofactor binding pocket; other site 1052588004999 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588005000 catalytic residue [active] 1052588005001 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 1052588005002 TRAM domain; Region: TRAM; cl01282 1052588005003 Protein of unknown function (DUF964); Region: DUF964; cl01483 1052588005004 Outer spore coat protein E (CotE); Region: CotE; pfam10628 1052588005005 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1052588005006 MutS domain I; Region: MutS_I; pfam01624 1052588005007 MutS domain II; Region: MutS_II; pfam05188 1052588005008 MutS family domain IV; Region: MutS_IV; pfam05190 1052588005009 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 1052588005010 Walker A/P-loop; other site 1052588005011 ATP binding site [chemical binding]; other site 1052588005012 Q-loop/lid; other site 1052588005013 ABC transporter signature motif; other site 1052588005014 Walker B; other site 1052588005015 D-loop; other site 1052588005016 H-loop/switch region; other site 1052588005017 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1052588005018 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588005019 ATP binding site [chemical binding]; other site 1052588005020 Mg2+ binding site [ion binding]; other site 1052588005021 G-X-G motif; other site 1052588005022 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1052588005023 ATP binding site [chemical binding]; other site 1052588005024 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 1052588005025 Regulatory protein YrvL; Region: YrvL; pfam14184 1052588005026 transcriptional regulator BetI; Validated; Region: PRK00767 1052588005027 Helix-turn-helix domains; Region: HTH; cl00088 1052588005028 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 1052588005029 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052588005030 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1052588005031 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1052588005032 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1052588005033 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1052588005034 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1052588005035 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1052588005036 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1052588005037 FMN binding site [chemical binding]; other site 1052588005038 substrate binding site [chemical binding]; other site 1052588005039 putative catalytic residue [active] 1052588005040 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588005041 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 1052588005042 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1052588005043 dimer interface [polypeptide binding]; other site 1052588005044 active site 1052588005045 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 1052588005046 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827 1052588005047 dimer interface [polypeptide binding]; other site 1052588005048 active site 1052588005049 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1052588005050 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1052588005051 substrate binding site [chemical binding]; other site 1052588005052 oxyanion hole (OAH) forming residues; other site 1052588005053 trimer interface [polypeptide binding]; other site 1052588005054 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1052588005055 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1052588005056 substrate binding site [chemical binding]; other site 1052588005057 oxyanion hole (OAH) forming residues; other site 1052588005058 trimer interface [polypeptide binding]; other site 1052588005059 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1052588005060 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588005061 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588005062 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588005063 Condensation domain; Region: Condensation; pfam00668 1052588005064 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052588005065 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052588005066 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588005067 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588005068 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588005069 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052588005070 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052588005071 active site 1052588005072 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052588005073 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052588005074 putative NADP binding site [chemical binding]; other site 1052588005075 active site 1052588005076 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588005077 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588005078 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052588005079 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052588005080 active site 1052588005081 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052588005082 putative NADP binding site [chemical binding]; other site 1052588005083 active site 1052588005084 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588005085 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052588005086 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052588005087 active site 1052588005088 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052588005089 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588005090 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052588005091 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052588005092 active site 1052588005093 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052588005094 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052588005095 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1052588005096 putative NADP binding site [chemical binding]; other site 1052588005097 active site 1052588005098 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588005099 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052588005100 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052588005101 active site 1052588005102 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588005103 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588005104 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052588005105 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052588005106 active site 1052588005107 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052588005108 putative NADP binding site [chemical binding]; other site 1052588005109 active site 1052588005110 peptide synthase; Provisional; Region: PRK12316 1052588005111 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588005112 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052588005113 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052588005114 active site 1052588005115 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052588005116 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588005117 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052588005118 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052588005119 active site 1052588005120 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052588005121 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052588005122 putative NADP binding site [chemical binding]; other site 1052588005123 active site 1052588005124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1052588005125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1052588005126 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588005127 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052588005128 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052588005129 active site 1052588005130 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588005131 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052588005132 putative NADP binding site [chemical binding]; other site 1052588005133 active site 1052588005134 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588005135 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052588005136 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052588005137 active site 1052588005138 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588005139 Condensation domain; Region: Condensation; pfam00668 1052588005140 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052588005141 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052588005142 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588005143 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588005144 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588005145 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052588005146 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052588005147 active site 1052588005148 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052588005149 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052588005150 putative NADP binding site [chemical binding]; other site 1052588005151 active site 1052588005152 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588005153 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052588005154 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052588005155 active site 1052588005156 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052588005157 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052588005158 putative NADP binding site [chemical binding]; other site 1052588005159 active site 1052588005160 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588005161 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052588005162 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052588005163 active site 1052588005164 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052588005165 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052588005166 putative NADP binding site [chemical binding]; other site 1052588005167 active site 1052588005168 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1052588005169 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588005170 S-adenosylmethionine binding site [chemical binding]; other site 1052588005171 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588005172 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052588005173 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052588005174 active site 1052588005175 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588005176 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052588005177 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052588005178 active site 1052588005179 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588005180 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1052588005181 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1052588005182 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052588005183 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 1052588005184 active site 1052588005185 catalytic triad [active] 1052588005186 WYL domain; Region: WYL; cl14852 1052588005187 Protein of unknown function (DUF867); Region: DUF867; cl01713 1052588005188 OsmC-like protein; Region: OsmC; cl00767 1052588005189 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1052588005190 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1052588005191 YmaF family; Region: YmaF; pfam12788 1052588005192 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588005193 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1052588005194 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 1052588005195 Sm1 motif; other site 1052588005196 intra - hexamer interaction site; other site 1052588005197 inter - hexamer interaction site [polypeptide binding]; other site 1052588005198 nucleotide binding pocket [chemical binding]; other site 1052588005199 Sm2 motif; other site 1052588005200 YmzC-like protein; Region: YmzC; pfam14157 1052588005201 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1052588005202 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1052588005203 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1052588005204 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1052588005205 active site 1052588005206 dimer interface [polypeptide binding]; other site 1052588005207 catalytic residues [active] 1052588005208 effector binding site; other site 1052588005209 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1052588005210 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1052588005211 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1052588005212 dimer interface [polypeptide binding]; other site 1052588005213 putative radical transfer pathway; other site 1052588005214 diiron center [ion binding]; other site 1052588005215 tyrosyl radical; other site 1052588005216 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1052588005217 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1052588005218 active site 1052588005219 metal binding site [ion binding]; metal-binding site 1052588005220 Sporulation related domain; Region: SPOR; cl10051 1052588005221 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1052588005222 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588005223 Walker A motif; other site 1052588005224 ATP binding site [chemical binding]; other site 1052588005225 Walker B motif; other site 1052588005226 arginine finger; other site 1052588005227 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1052588005228 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1052588005229 HflX GTPase family; Region: HflX; cd01878 1052588005230 G1 box; other site 1052588005231 GTP/Mg2+ binding site [chemical binding]; other site 1052588005232 Switch I region; other site 1052588005233 G2 box; other site 1052588005234 G3 box; other site 1052588005235 Switch II region; other site 1052588005236 G4 box; other site 1052588005237 G5 box; other site 1052588005238 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1052588005239 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1052588005240 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052588005241 catalytic residue [active] 1052588005242 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1052588005243 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1052588005244 DNA binding residues [nucleotide binding] 1052588005245 putative dimer interface [polypeptide binding]; other site 1052588005246 glutamine synthetase, type I; Region: GlnA; TIGR00653 1052588005247 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1052588005248 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1052588005249 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1052588005250 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1052588005251 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1052588005252 active site 1052588005253 catalytic site [active] 1052588005254 Holin family; Region: Phage_holin_4; cl01989 1052588005255 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1052588005256 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1052588005257 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 1052588005258 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1052588005259 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052588005260 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 1052588005261 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1052588005262 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1052588005263 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1052588005264 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1052588005265 inhibitor binding site; inhibition site 1052588005266 active site 1052588005267 Helix-turn-helix domains; Region: HTH; cl00088 1052588005268 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1052588005269 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1052588005270 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 1052588005271 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1052588005272 N- and C-terminal domain interface [polypeptide binding]; other site 1052588005273 D-xylulose kinase; Region: XylB; TIGR01312 1052588005274 active site 1052588005275 catalytic site [active] 1052588005276 metal binding site [ion binding]; metal-binding site 1052588005277 xylulose binding site [chemical binding]; other site 1052588005278 putative ATP binding site [chemical binding]; other site 1052588005279 homodimer interface [polypeptide binding]; other site 1052588005280 Staphylococcal nuclease homologues; Region: SNc; smart00318 1052588005281 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1052588005282 Catalytic site; other site 1052588005283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588005284 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1052588005285 putative substrate translocation pore; other site 1052588005286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588005287 alanine racemase; Region: alr; TIGR00492 1052588005288 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1052588005289 active site 1052588005290 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1052588005291 dimer interface [polypeptide binding]; other site 1052588005292 substrate binding site [chemical binding]; other site 1052588005293 catalytic residues [active] 1052588005294 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 1052588005295 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1052588005296 trimer interface [polypeptide binding]; other site 1052588005297 active site 1052588005298 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1052588005299 dimerization interface [polypeptide binding]; other site 1052588005300 active site 1052588005301 YoqO-like protein; Region: YoqO; pfam14037 1052588005302 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1052588005303 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1052588005304 putative hydrophobic ligand binding site [chemical binding]; other site 1052588005305 Spore germination protein; Region: Spore_permease; cl15802 1052588005306 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 1052588005307 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 1052588005308 YndJ-like protein; Region: YndJ; pfam14158 1052588005309 Protein of unknown function (DUF867); Region: DUF867; cl01713 1052588005310 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1052588005311 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052588005312 FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363 1052588005313 putative active site [active] 1052588005314 putative Mg binding site [ion binding]; other site 1052588005315 LexA repressor; Validated; Region: PRK00215 1052588005316 Helix-turn-helix domains; Region: HTH; cl00088 1052588005317 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1052588005318 Catalytic site [active] 1052588005319 cell division suppressor protein YneA; Provisional; Region: PRK14125 1052588005320 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 1052588005321 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1052588005322 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1052588005323 catalytic residues [active] 1052588005324 catalytic nucleophile [active] 1052588005325 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 1052588005326 transketolase, bacterial and yeast; Region: tktlase_bact; TIGR00232 1052588005327 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1052588005328 TPP-binding site [chemical binding]; other site 1052588005329 dimer interface [polypeptide binding]; other site 1052588005330 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1052588005331 PYR/PP interface [polypeptide binding]; other site 1052588005332 dimer interface [polypeptide binding]; other site 1052588005333 TPP binding site [chemical binding]; other site 1052588005334 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1052588005335 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 1052588005336 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 1052588005337 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1052588005338 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1052588005339 Response regulator receiver domain; Region: Response_reg; pfam00072 1052588005340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588005341 active site 1052588005342 phosphorylation site [posttranslational modification] 1052588005343 intermolecular recognition site; other site 1052588005344 dimerization interface [polypeptide binding]; other site 1052588005345 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 1052588005346 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 1052588005347 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1052588005348 putative dimer interface [polypeptide binding]; other site 1052588005349 Small acid-soluble spore protein P family; Region: SspP; cl12105 1052588005350 Small acid-soluble spore protein O family; Region: SspO; cl07943 1052588005351 aconitate hydratase; Validated; Region: PRK09277 1052588005352 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1052588005353 substrate binding site [chemical binding]; other site 1052588005354 ligand binding site [chemical binding]; other site 1052588005355 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1052588005356 substrate binding site [chemical binding]; other site 1052588005357 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 1052588005358 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1052588005359 catalytic residues [active] 1052588005360 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1052588005361 Small acid-soluble spore protein N family; Region: SspN; cl11659 1052588005362 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830; cl07951 1052588005363 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1052588005364 active site 1052588005365 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1052588005366 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 1052588005367 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588005368 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 1052588005369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588005370 ATP binding site [chemical binding]; other site 1052588005371 Mg2+ binding site [ion binding]; other site 1052588005372 G-X-G motif; other site 1052588005373 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1052588005374 anchoring element; other site 1052588005375 dimer interface [polypeptide binding]; other site 1052588005376 ATP binding site [chemical binding]; other site 1052588005377 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1052588005378 active site 1052588005379 putative metal-binding site [ion binding]; other site 1052588005380 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1052588005381 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 1052588005382 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 1052588005383 CAP-like domain; other site 1052588005384 active site 1052588005385 primary dimer interface [polypeptide binding]; other site 1052588005386 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052588005387 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052588005388 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052588005389 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052588005390 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1052588005391 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1052588005392 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1052588005393 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 1052588005394 Cellulose binding domain; Region: CBM_3; cl03026 1052588005395 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1052588005396 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1052588005397 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 1052588005398 substrate binding site [chemical binding]; other site 1052588005399 active site 1052588005400 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1052588005401 metal binding site [ion binding]; metal-binding site 1052588005402 ligand binding site [chemical binding]; other site 1052588005403 GtrA-like protein; Region: GtrA; cl00971 1052588005404 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1052588005405 active site 1052588005406 tetramer interface; other site 1052588005407 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1052588005408 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 1052588005409 DHH family; Region: DHH; pfam01368 1052588005410 DHHA1 domain; Region: DHHA1; pfam02272 1052588005411 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1052588005412 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1052588005413 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1052588005414 enoyl-CoA hydratase; Provisional; Region: PRK07657 1052588005415 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1052588005416 substrate binding site [chemical binding]; other site 1052588005417 oxyanion hole (OAH) forming residues; other site 1052588005418 trimer interface [polypeptide binding]; other site 1052588005419 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1052588005420 active site 1052588005421 catalytic residues [active] 1052588005422 metal binding site [ion binding]; metal-binding site 1052588005423 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1052588005424 carboxyltransferase (CT) interaction site; other site 1052588005425 biotinylation site [posttranslational modification]; other site 1052588005426 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 1052588005427 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052588005428 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1052588005429 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1052588005430 AMP-binding domain protein; Validated; Region: PRK08315 1052588005431 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588005432 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052588005433 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1052588005434 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1052588005435 active site 1052588005436 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052588005437 Helix-turn-helix domains; Region: HTH; cl00088 1052588005438 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052588005439 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052588005440 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 1052588005441 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1052588005442 peptide synthase; Provisional; Region: PRK12467 1052588005443 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588005444 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588005445 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588005446 peptide synthase; Provisional; Region: PRK12467 1052588005447 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588005448 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588005449 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052588005450 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588005451 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588005452 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588005453 peptide synthase; Provisional; Region: PRK12316 1052588005454 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052588005455 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588005456 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588005457 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052588005458 peptide synthase; Provisional; Region: PRK12467 1052588005459 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588005460 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588005461 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588005462 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052588005463 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588005464 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588005465 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052588005466 peptide synthase; Provisional; Region: PRK12467 1052588005467 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588005468 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588005469 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052588005470 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588005471 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588005472 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052588005473 peptide synthase; Provisional; Region: PRK12316 1052588005474 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052588005475 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588005476 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588005477 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588005478 peptide synthase; Provisional; Region: PRK12316 1052588005479 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052588005480 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588005481 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588005482 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588005483 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052588005484 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 1052588005485 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052588005486 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 1052588005487 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 1052588005488 active site 1052588005489 catalytic residues [active] 1052588005490 MatE; Region: MatE; cl10513 1052588005491 putative efflux protein, MATE family; Region: matE; TIGR00797 1052588005492 MatE; Region: MatE; cl10513 1052588005493 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1052588005494 Int/Topo IB signature motif; other site 1052588005495 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1052588005496 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1052588005497 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1052588005498 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052588005499 Helix-turn-helix domains; Region: HTH; cl00088 1052588005500 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1052588005501 putative dimerization interface [polypeptide binding]; other site 1052588005502 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1052588005503 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1052588005504 NAD(P) binding site [chemical binding]; other site 1052588005505 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 1052588005506 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588005507 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1052588005508 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1052588005509 active site 1052588005510 dimer interface [polypeptide binding]; other site 1052588005511 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1052588005512 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1052588005513 active site 1052588005514 FMN binding site [chemical binding]; other site 1052588005515 substrate binding site [chemical binding]; other site 1052588005516 3Fe-4S cluster binding site [ion binding]; other site 1052588005517 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1052588005518 domain interface; other site 1052588005519 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052588005520 Helix-turn-helix domains; Region: HTH; cl00088 1052588005521 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1052588005522 putative dimerization interface [polypeptide binding]; other site 1052588005523 gamma-glutamyl kinase; Provisional; Region: PRK13402 1052588005524 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1052588005525 nucleotide binding site [chemical binding]; other site 1052588005526 homotetrameric interface [polypeptide binding]; other site 1052588005527 putative phosphate binding site [ion binding]; other site 1052588005528 putative allosteric binding site; other site 1052588005529 PUA domain; Region: PUA; cl00607 1052588005530 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588005531 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 1052588005532 Replication terminator protein; Region: RTP; pfam02334 1052588005533 classical (c) SDRs; Region: SDR_c; cd05233 1052588005534 NAD(P) binding site [chemical binding]; other site 1052588005535 active site 1052588005536 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 1052588005537 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1052588005538 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052588005539 polyol permease family; Region: 2A0118; TIGR00897 1052588005540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588005541 putative substrate translocation pore; other site 1052588005542 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1052588005543 Autoinducer-2 kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K_like; cd07798 1052588005544 putative N- and C-terminal domain interface [polypeptide binding]; other site 1052588005545 putative active site [active] 1052588005546 putative MgATP binding site [chemical binding]; other site 1052588005547 catalytic site [active] 1052588005548 metal binding site [ion binding]; metal-binding site 1052588005549 carbohydrate binding site [chemical binding]; other site 1052588005550 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1052588005551 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588005552 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1052588005553 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1052588005554 putative [4Fe-4S] binding site [ion binding]; other site 1052588005555 putative molybdopterin cofactor binding site [chemical binding]; other site 1052588005556 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 1052588005557 putative molybdopterin cofactor binding site; other site 1052588005558 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052588005559 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588005560 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1052588005561 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1052588005562 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052588005563 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052588005564 DNA binding site [nucleotide binding] 1052588005565 domain linker motif; other site 1052588005566 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1052588005567 dimerization interface [polypeptide binding]; other site 1052588005568 ligand binding site [chemical binding]; other site 1052588005569 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 1052588005570 CHASE3 domain; Region: CHASE3; cl05000 1052588005571 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052588005572 dimerization interface [polypeptide binding]; other site 1052588005573 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052588005574 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052588005575 dimer interface [polypeptide binding]; other site 1052588005576 putative CheW interface [polypeptide binding]; other site 1052588005577 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 1052588005578 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1052588005579 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 1052588005580 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 1052588005581 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 1052588005582 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1052588005583 Pectate lyase; Region: Pec_lyase_C; cl01593 1052588005584 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1052588005585 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1052588005586 Cupin domain; Region: Cupin_2; cl09118 1052588005587 Cupin domain; Region: Cupin_2; cl09118 1052588005588 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1052588005589 VanW like protein; Region: VanW; pfam04294 1052588005590 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 1052588005591 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1052588005592 Protein of unknown function (DUF817); Region: DUF817; cl01520 1052588005593 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052588005594 Helix-turn-helix domains; Region: HTH; cl00088 1052588005595 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052588005596 dimerization interface [polypeptide binding]; other site 1052588005597 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1052588005598 EamA-like transporter family; Region: EamA; cl01037 1052588005599 EamA-like transporter family; Region: EamA; cl01037 1052588005600 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 1052588005601 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1052588005602 conserved cys residue [active] 1052588005603 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1052588005604 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052588005605 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 1052588005606 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1052588005607 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1052588005608 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1052588005609 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 1052588005610 TM2 domain; Region: TM2; cl00984 1052588005611 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052588005612 non-specific DNA binding site [nucleotide binding]; other site 1052588005613 salt bridge; other site 1052588005614 sequence-specific DNA binding site [nucleotide binding]; other site 1052588005615 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1052588005616 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1052588005617 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1052588005618 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052588005619 Helix-turn-helix domains; Region: HTH; cl00088 1052588005620 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052588005621 dimerization interface [polypeptide binding]; other site 1052588005622 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1052588005623 putative deacylase active site [active] 1052588005624 EamA-like transporter family; Region: EamA; cl01037 1052588005625 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1052588005626 EamA-like transporter family; Region: EamA; cl01037 1052588005627 Bacteriophage holin; Region: Phage_holin_1; cl02344 1052588005628 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052588005629 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052588005630 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1052588005631 LXG domain of WXG superfamily; Region: LXG; pfam04740 1052588005632 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1052588005633 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1052588005634 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1052588005635 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1052588005636 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1052588005637 dimer interface [polypeptide binding]; other site 1052588005638 putative tRNA-binding site [nucleotide binding]; other site 1052588005639 Cupin domain; Region: Cupin_2; cl09118 1052588005640 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052588005641 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052588005642 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052588005643 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1052588005644 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588005645 Coenzyme A binding pocket [chemical binding]; other site 1052588005646 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052588005647 Helix-turn-helix domains; Region: HTH; cl00088 1052588005648 WHG domain; Region: WHG; pfam13305 1052588005649 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052588005650 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1052588005651 Predicted transcriptional regulator [Transcription]; Region: COG2378 1052588005652 Helix-turn-helix domains; Region: HTH; cl00088 1052588005653 WYL domain; Region: WYL; cl14852 1052588005654 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052588005655 dimerization interface [polypeptide binding]; other site 1052588005656 putative DNA binding site [nucleotide binding]; other site 1052588005657 putative Zn2+ binding site [ion binding]; other site 1052588005658 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1052588005659 Protein of unknown function (DUF420); Region: DUF420; cl00989 1052588005660 Protein required for attachment to host cells; Region: Host_attach; cl02398 1052588005661 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052588005662 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1052588005663 putative dimer interface [polypeptide binding]; other site 1052588005664 catalytic triad [active] 1052588005665 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1052588005666 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1052588005667 putative di-iron ligands [ion binding]; other site 1052588005668 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052588005669 Histidine kinase; Region: HisKA_3; pfam07730 1052588005670 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1052588005671 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052588005672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588005673 active site 1052588005674 phosphorylation site [posttranslational modification] 1052588005675 intermolecular recognition site; other site 1052588005676 dimerization interface [polypeptide binding]; other site 1052588005677 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052588005678 DNA binding residues [nucleotide binding] 1052588005679 dimerization interface [polypeptide binding]; other site 1052588005680 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588005681 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588005682 3D domain; Region: 3D; cl01439 1052588005683 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1052588005684 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052588005685 ATP binding site [chemical binding]; other site 1052588005686 putative Mg++ binding site [ion binding]; other site 1052588005687 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052588005688 nucleotide binding region [chemical binding]; other site 1052588005689 ATP-binding site [chemical binding]; other site 1052588005690 RQC domain; Region: RQC; cl09632 1052588005691 HRDC domain; Region: HRDC; cl02578 1052588005692 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1052588005693 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1052588005694 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1052588005695 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1052588005696 putative dimer interface [polypeptide binding]; other site 1052588005697 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 1052588005698 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 1052588005699 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1052588005700 NAD(P) binding site [chemical binding]; other site 1052588005701 catalytic residues [active] 1052588005702 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 1052588005703 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1052588005704 Active site cavity [active] 1052588005705 Squalene cyclase [Lipid metabolism]; Region: SqhC; COG1657 1052588005706 catalytic acid [active] 1052588005707 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1052588005708 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1052588005709 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1052588005710 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1052588005711 Na2 binding site [ion binding]; other site 1052588005712 putative substrate binding site 1 [chemical binding]; other site 1052588005713 Na binding site 1 [ion binding]; other site 1052588005714 putative substrate binding site 2 [chemical binding]; other site 1052588005715 bile acid transporter; Region: bass; TIGR00841 1052588005716 Membrane transport protein; Region: Mem_trans; cl09117 1052588005717 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1052588005718 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1052588005719 E3 interaction surface; other site 1052588005720 lipoyl attachment site [posttranslational modification]; other site 1052588005721 e3 binding domain; Region: E3_binding; pfam02817 1052588005722 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 1052588005723 2-oxoglutarate dehydrogenase, E1 component; Region: 2oxo_dh_E1; TIGR00239 1052588005724 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1052588005725 TPP-binding site [chemical binding]; other site 1052588005726 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1052588005727 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1052588005728 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1052588005729 metal ion-dependent adhesion site (MIDAS); other site 1052588005730 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588005731 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1052588005732 Walker A motif; other site 1052588005733 ATP binding site [chemical binding]; other site 1052588005734 Walker B motif; other site 1052588005735 arginine finger; other site 1052588005736 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1052588005737 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1052588005738 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1052588005739 E-class dimer interface [polypeptide binding]; other site 1052588005740 P-class dimer interface [polypeptide binding]; other site 1052588005741 active site 1052588005742 Cu2+ binding site [ion binding]; other site 1052588005743 Zn2+ binding site [ion binding]; other site 1052588005744 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588005745 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588005746 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588005747 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588005748 NlpC/P60 family; Region: NLPC_P60; cl11438 1052588005749 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1052588005750 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1052588005751 active site 1052588005752 TDP-binding site; other site 1052588005753 acceptor substrate-binding pocket; other site 1052588005754 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 1052588005755 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1052588005756 multidrug efflux protein; Reviewed; Region: PRK01766 1052588005757 MatE; Region: MatE; cl10513 1052588005758 MatE; Region: MatE; cl10513 1052588005759 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1052588005760 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1052588005761 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1052588005762 rarD protein; Region: rarD; TIGR00688 1052588005763 EamA-like transporter family; Region: EamA; cl01037 1052588005764 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 1052588005765 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1052588005766 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052588005767 dimerization interface [polypeptide binding]; other site 1052588005768 putative DNA binding site [nucleotide binding]; other site 1052588005769 putative Zn2+ binding site [ion binding]; other site 1052588005770 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1052588005771 dimer interface [polypeptide binding]; other site 1052588005772 FMN binding site [chemical binding]; other site 1052588005773 Predicted esterase [General function prediction only]; Region: COG0400 1052588005774 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1052588005775 Zn binding site [ion binding]; other site 1052588005776 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1052588005777 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052588005778 Zn binding site [ion binding]; other site 1052588005779 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1052588005780 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 1052588005781 Na binding site [ion binding]; other site 1052588005782 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1052588005783 C-terminal peptidase (prc); Region: prc; TIGR00225 1052588005784 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1052588005785 protein binding site [polypeptide binding]; other site 1052588005786 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1052588005787 Catalytic dyad [active] 1052588005788 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1052588005789 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1052588005790 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588005791 S-adenosylmethionine binding site [chemical binding]; other site 1052588005792 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 1052588005793 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1052588005794 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1052588005795 YodL-like; Region: YodL; pfam14191 1052588005796 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1052588005797 active site 1052588005798 YozD-like protein; Region: YozD; pfam14162 1052588005799 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 1052588005800 YokU-like protein; Region: YokU; cl15819 1052588005801 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 1052588005802 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052588005803 FeS/SAM binding site; other site 1052588005804 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 1052588005805 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 1052588005806 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588005807 Coenzyme A binding pocket [chemical binding]; other site 1052588005808 acetylornithine deacetylase; Validated; Region: PRK06915 1052588005809 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 1052588005810 metal binding site [ion binding]; metal-binding site 1052588005811 dimer interface [polypeptide binding]; other site 1052588005812 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1052588005813 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1052588005814 hypothetical protein; Provisional; Region: PRK06917 1052588005815 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052588005816 inhibitor-cofactor binding pocket; inhibition site 1052588005817 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588005818 catalytic residue [active] 1052588005819 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588005820 Coenzyme A binding pocket [chemical binding]; other site 1052588005821 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052588005822 active site 1052588005823 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1052588005824 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1052588005825 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1052588005826 3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase) [Lipid metabolism]; Region: Phy; COG4247 1052588005827 Phytase; Region: Phytase; pfam02333 1052588005828 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1052588005829 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 1052588005830 NAD(P) binding site [chemical binding]; other site 1052588005831 homodimer interface [polypeptide binding]; other site 1052588005832 substrate binding site [chemical binding]; other site 1052588005833 active site 1052588005834 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 1052588005835 SelR domain; Region: SelR; pfam01641 1052588005836 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 1052588005837 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588005838 Helix-turn-helix domains; Region: HTH; cl00088 1052588005839 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1052588005840 MatE; Region: MatE; cl10513 1052588005841 MatE; Region: MatE; cl10513 1052588005842 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 1052588005843 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1052588005844 active site 1052588005845 catalytic triad [active] 1052588005846 oxyanion hole [active] 1052588005847 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1052588005848 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1052588005849 Cu(I) binding site [ion binding]; other site 1052588005850 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 1052588005851 threonine dehydratase; Validated; Region: PRK08639 1052588005852 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1052588005853 tetramer interface [polypeptide binding]; other site 1052588005854 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588005855 catalytic residue [active] 1052588005856 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1052588005857 putative Ile/Val binding site [chemical binding]; other site 1052588005858 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588005859 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1052588005860 Walker A motif; other site 1052588005861 ATP binding site [chemical binding]; other site 1052588005862 Walker B motif; other site 1052588005863 arginine finger; other site 1052588005864 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 1052588005865 Haemolysin-III related; Region: HlyIII; cl03831 1052588005866 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052588005867 putative acyl-acceptor binding pocket; other site 1052588005868 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1052588005869 folate binding site [chemical binding]; other site 1052588005870 NADP+ binding site [chemical binding]; other site 1052588005871 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1052588005872 tetramer interfaces [polypeptide binding]; other site 1052588005873 binuclear metal-binding site [ion binding]; other site 1052588005874 YpjP-like protein; Region: YpjP; pfam14005 1052588005875 Brix domain; Region: Brix; cl00935 1052588005876 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1052588005877 Disulphide isomerase; Region: Disulph_isomer; cl05813 1052588005878 Dehydratase family; Region: ILVD_EDD; cl00340 1052588005879 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 1052588005880 Virulence factor; Region: Virulence_fact; pfam13769 1052588005881 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 1052588005882 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 1052588005883 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 1052588005884 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1052588005885 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1052588005886 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1052588005887 catalytic residues [active] 1052588005888 dimer interface [polypeptide binding]; other site 1052588005889 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1052588005890 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1052588005891 proposed active site lysine [active] 1052588005892 conserved cys residue [active] 1052588005893 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 1052588005894 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1052588005895 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1052588005896 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1052588005897 DNA-binding site [nucleotide binding]; DNA binding site 1052588005898 RNA-binding motif; other site 1052588005899 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 1052588005900 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 1052588005901 hypothetical protein; Validated; Region: PRK07708 1052588005902 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1052588005903 RNA/DNA hybrid binding site [nucleotide binding]; other site 1052588005904 active site 1052588005905 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 1052588005906 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1052588005907 RNA/DNA hybrid binding site [nucleotide binding]; other site 1052588005908 active site 1052588005909 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 1052588005910 5'-3' exonuclease; Region: 53EXOc; smart00475 1052588005911 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1052588005912 active site 1052588005913 metal binding site 1 [ion binding]; metal-binding site 1052588005914 putative 5' ssDNA interaction site; other site 1052588005915 metal binding site 3; metal-binding site 1052588005916 metal binding site 2 [ion binding]; metal-binding site 1052588005917 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1052588005918 putative DNA binding site [nucleotide binding]; other site 1052588005919 putative metal binding site [ion binding]; other site 1052588005920 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 1052588005921 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1052588005922 Dynamin family; Region: Dynamin_N; pfam00350 1052588005923 G1 box; other site 1052588005924 GTP/Mg2+ binding site [chemical binding]; other site 1052588005925 G2 box; other site 1052588005926 Switch I region; other site 1052588005927 G3 box; other site 1052588005928 Switch II region; other site 1052588005929 G4 box; other site 1052588005930 G5 box; other site 1052588005931 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588005932 G1 box; other site 1052588005933 GTP/Mg2+ binding site [chemical binding]; other site 1052588005934 Dynamin family; Region: Dynamin_N; pfam00350 1052588005935 G2 box; other site 1052588005936 Switch I region; other site 1052588005937 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1052588005938 G3 box; other site 1052588005939 Switch II region; other site 1052588005940 GTP/Mg2+ binding site [chemical binding]; other site 1052588005941 G4 box; other site 1052588005942 G5 box; other site 1052588005943 Phospholipid methyltransferase; Region: PEMT; cl00763 1052588005944 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1052588005945 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1052588005946 malonyl-CoA binding site [chemical binding]; other site 1052588005947 dimer interface [polypeptide binding]; other site 1052588005948 active site 1052588005949 product binding site; other site 1052588005950 xanthine permease; Region: pbuX; TIGR03173 1052588005951 Sulfate transporter family; Region: Sulfate_transp; cl15842 1052588005952 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052588005953 active site 1052588005954 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1052588005955 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1052588005956 active site 1052588005957 Zn binding site [ion binding]; other site 1052588005958 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 1052588005959 KDPG and KHG aldolase; Region: Aldolase; pfam01081 1052588005960 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1052588005961 active site 1052588005962 intersubunit interface [polypeptide binding]; other site 1052588005963 catalytic residue [active] 1052588005964 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1052588005965 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1052588005966 substrate binding site [chemical binding]; other site 1052588005967 ATP binding site [chemical binding]; other site 1052588005968 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052588005969 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052588005970 DNA binding site [nucleotide binding] 1052588005971 domain linker motif; other site 1052588005972 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1052588005973 putative dimerization interface [polypeptide binding]; other site 1052588005974 putative ligand binding site [chemical binding]; other site 1052588005975 KduI/IolB family; Region: KduI; cl01508 1052588005976 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 1052588005977 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1052588005978 NADP binding site [chemical binding]; other site 1052588005979 homodimer interface [polypeptide binding]; other site 1052588005980 active site 1052588005981 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1052588005982 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588005983 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588005984 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1052588005985 THUMP domain; Region: THUMP; cl12076 1052588005986 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1052588005987 cell division protein GpsB; Provisional; Region: PRK14127 1052588005988 DivIVA domain; Region: DivI1A_domain; TIGR03544 1052588005989 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 1052588005990 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 1052588005991 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1052588005992 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1052588005993 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1052588005994 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052588005995 ATP binding site [chemical binding]; other site 1052588005996 putative Mg++ binding site [ion binding]; other site 1052588005997 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052588005998 nucleotide binding region [chemical binding]; other site 1052588005999 ATP-binding site [chemical binding]; other site 1052588006000 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1052588006001 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 1052588006002 HPr interaction site; other site 1052588006003 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1052588006004 active site 1052588006005 phosphorylation site [posttranslational modification] 1052588006006 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 1052588006007 YppG-like protein; Region: YppG; pfam14179 1052588006008 YppF-like protein; Region: YppF; pfam14178 1052588006009 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1052588006010 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 1052588006011 Recombination protein U; Region: RecU; cl01314 1052588006012 Transglycosylase; Region: Transgly; cl07896 1052588006013 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1052588006014 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052588006015 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 1052588006016 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1052588006017 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1052588006018 minor groove reading motif; other site 1052588006019 helix-hairpin-helix signature motif; other site 1052588006020 substrate binding pocket [chemical binding]; other site 1052588006021 active site 1052588006022 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1052588006023 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1052588006024 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 1052588006025 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1052588006026 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1052588006027 putative dimer interface [polypeptide binding]; other site 1052588006028 putative anticodon binding site; other site 1052588006029 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1052588006030 homodimer interface [polypeptide binding]; other site 1052588006031 motif 1; other site 1052588006032 motif 2; other site 1052588006033 active site 1052588006034 motif 3; other site 1052588006035 aspartate aminotransferase; Provisional; Region: PRK05764 1052588006036 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052588006037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588006038 homodimer interface [polypeptide binding]; other site 1052588006039 catalytic residue [active] 1052588006040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1052588006041 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 1052588006042 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 1052588006043 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1052588006044 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1052588006045 active site 1052588006046 catalytic site [active] 1052588006047 substrate binding site [chemical binding]; other site 1052588006048 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588006049 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1052588006050 tetramerization interface [polypeptide binding]; other site 1052588006051 active site 1052588006052 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1052588006053 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1052588006054 active site 1052588006055 ATP-binding site [chemical binding]; other site 1052588006056 pantoate-binding site; other site 1052588006057 HXXH motif; other site 1052588006058 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1052588006059 oligomerization interface [polypeptide binding]; other site 1052588006060 active site 1052588006061 metal binding site [ion binding]; metal-binding site 1052588006062 Helix-turn-helix domains; Region: HTH; cl00088 1052588006063 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 1052588006064 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1052588006065 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1052588006066 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1052588006067 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1052588006068 active site 1052588006069 NTP binding site [chemical binding]; other site 1052588006070 metal binding triad [ion binding]; metal-binding site 1052588006071 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1052588006072 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1052588006073 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1052588006074 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1052588006075 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1052588006076 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1052588006077 active site 1052588006078 dimer interfaces [polypeptide binding]; other site 1052588006079 catalytic residues [active] 1052588006080 dihydrodipicolinate reductase; Region: dapB; TIGR00036 1052588006081 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588006082 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1052588006083 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1052588006084 homodimer interface [polypeptide binding]; other site 1052588006085 metal binding site [ion binding]; metal-binding site 1052588006086 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1052588006087 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052588006088 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052588006089 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 1052588006090 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 1052588006091 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 1052588006092 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 1052588006093 Cytochrome c; Region: Cytochrom_C; cl11414 1052588006094 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1052588006095 interchain domain interface [polypeptide binding]; other site 1052588006096 intrachain domain interface; other site 1052588006097 heme bH binding site [chemical binding]; other site 1052588006098 Qi binding site; other site 1052588006099 heme bL binding site [chemical binding]; other site 1052588006100 Qo binding site; other site 1052588006101 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1052588006102 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 1052588006103 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1052588006104 iron-sulfur cluster [ion binding]; other site 1052588006105 [2Fe-2S] cluster binding site [ion binding]; other site 1052588006106 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 1052588006107 hypothetical protein; Provisional; Region: PRK03636 1052588006108 UPF0302 domain; Region: UPF0302; pfam08864 1052588006109 IDEAL domain; Region: IDEAL; cl07452 1052588006110 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588006111 TPR motif; other site 1052588006112 binding surface 1052588006113 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588006114 binding surface 1052588006115 TPR motif; other site 1052588006116 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1052588006117 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588006118 TPR motif; other site 1052588006119 binding surface 1052588006120 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1052588006121 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588006122 binding surface 1052588006123 TPR motif; other site 1052588006124 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1052588006125 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 1052588006126 hinge; other site 1052588006127 active site 1052588006128 prephenate dehydrogenase; Validated; Region: PRK06545 1052588006129 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588006130 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1052588006131 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1052588006132 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052588006133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588006134 homodimer interface [polypeptide binding]; other site 1052588006135 catalytic residue [active] 1052588006136 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 1052588006137 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1052588006138 substrate binding site [chemical binding]; other site 1052588006139 active site 1052588006140 catalytic residues [active] 1052588006141 heterodimer interface [polypeptide binding]; other site 1052588006142 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1052588006143 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1052588006144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588006145 catalytic residue [active] 1052588006146 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 1052588006147 active site 1052588006148 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1052588006149 active site 1052588006150 ribulose/triose binding site [chemical binding]; other site 1052588006151 phosphate binding site [ion binding]; other site 1052588006152 substrate (anthranilate) binding pocket [chemical binding]; other site 1052588006153 product (indole) binding pocket [chemical binding]; other site 1052588006154 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1052588006155 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1052588006156 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1052588006157 anthranilate synthase component I; Provisional; Region: PRK13569 1052588006158 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1052588006159 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1052588006160 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 1052588006161 homotrimer interaction site [polypeptide binding]; other site 1052588006162 active site 1052588006163 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1052588006164 active site 1052588006165 dimer interface [polypeptide binding]; other site 1052588006166 metal binding site [ion binding]; metal-binding site 1052588006167 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1052588006168 Tetramer interface [polypeptide binding]; other site 1052588006169 active site 1052588006170 FMN-binding site [chemical binding]; other site 1052588006171 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1052588006172 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1052588006173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588006174 S-adenosylmethionine binding site [chemical binding]; other site 1052588006175 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1052588006176 active site 1052588006177 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1052588006178 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1052588006179 substrate binding pocket [chemical binding]; other site 1052588006180 chain length determination region; other site 1052588006181 substrate-Mg2+ binding site; other site 1052588006182 catalytic residues [active] 1052588006183 aspartate-rich region 1; other site 1052588006184 active site lid residues [active] 1052588006185 aspartate-rich region 2; other site 1052588006186 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1052588006187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588006188 S-adenosylmethionine binding site [chemical binding]; other site 1052588006189 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1052588006190 Tryptophan RNA-binding attenuator protein; Region: TrpBP; cl03437 1052588006191 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1052588006192 homodecamer interface [polypeptide binding]; other site 1052588006193 GTP cyclohydrolase I; Provisional; Region: PLN03044 1052588006194 active site 1052588006195 putative catalytic site residues [active] 1052588006196 zinc binding site [ion binding]; other site 1052588006197 GTP-CH-I/GFRP interaction surface; other site 1052588006198 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1052588006199 IHF dimer interface [polypeptide binding]; other site 1052588006200 IHF - DNA interface [nucleotide binding]; other site 1052588006201 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 1052588006202 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1052588006203 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588006204 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1052588006205 GTP-binding protein Der; Reviewed; Region: PRK00093 1052588006206 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1052588006207 G1 box; other site 1052588006208 GTP/Mg2+ binding site [chemical binding]; other site 1052588006209 Switch I region; other site 1052588006210 G2 box; other site 1052588006211 Switch II region; other site 1052588006212 G3 box; other site 1052588006213 G4 box; other site 1052588006214 G5 box; other site 1052588006215 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1052588006216 G1 box; other site 1052588006217 GTP/Mg2+ binding site [chemical binding]; other site 1052588006218 Switch I region; other site 1052588006219 G2 box; other site 1052588006220 G3 box; other site 1052588006221 Switch II region; other site 1052588006222 G4 box; other site 1052588006223 G5 box; other site 1052588006224 YIEGIA protein; Region: YIEGIA; pfam14045 1052588006225 YpzI-like protein; Region: YpzI; pfam14140 1052588006226 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1052588006227 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1052588006228 homotetramer interface [polypeptide binding]; other site 1052588006229 FMN binding site [chemical binding]; other site 1052588006230 homodimer contacts [polypeptide binding]; other site 1052588006231 putative active site [active] 1052588006232 putative substrate binding site [chemical binding]; other site 1052588006233 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1052588006234 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1052588006235 RNA binding site [nucleotide binding]; other site 1052588006236 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1052588006237 RNA binding site [nucleotide binding]; other site 1052588006238 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1052588006239 RNA binding site [nucleotide binding]; other site 1052588006240 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 1052588006241 RNA binding site [nucleotide binding]; other site 1052588006242 cytidylate kinase; Provisional; Region: cmk; PRK00023 1052588006243 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1052588006244 CMP-binding site; other site 1052588006245 The sites determining sugar specificity; other site 1052588006246 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1052588006247 Flagellar protein YcgR; Region: YcgR_2; pfam12945 1052588006248 PilZ domain; Region: PilZ; cl01260 1052588006249 germination protein YpeB; Region: spore_YpeB; TIGR02889 1052588006250 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1052588006251 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1052588006252 Protease prsW family; Region: PrsW-protease; cl15823 1052588006253 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1052588006254 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588006255 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052588006256 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1052588006257 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1052588006258 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1052588006259 NAD(P) binding site [chemical binding]; other site 1052588006260 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 1052588006261 Predicted phosphohydrolases [General function prediction only]; Region: COG1408 1052588006262 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1052588006263 putative active site [active] 1052588006264 putative metal binding site [ion binding]; other site 1052588006265 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 1052588006266 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588006267 CAAX protease self-immunity; Region: Abi; cl00558 1052588006268 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1052588006269 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052588006270 ATP binding site [chemical binding]; other site 1052588006271 putative Mg++ binding site [ion binding]; other site 1052588006272 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052588006273 nucleotide binding region [chemical binding]; other site 1052588006274 ATP-binding site [chemical binding]; other site 1052588006275 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1052588006276 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1052588006277 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 1052588006278 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1052588006279 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 1052588006280 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588006281 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1052588006282 putative L-serine binding site [chemical binding]; other site 1052588006283 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1052588006284 3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093 1052588006285 active site 1052588006286 catalytic residue [active] 1052588006287 dimer interface [polypeptide binding]; other site 1052588006288 Sporulation and spore germination; Region: Germane; cl11253 1052588006289 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 1052588006290 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052588006291 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588006292 DNA binding residues [nucleotide binding] 1052588006293 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1052588006294 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052588006295 dimerization interface [polypeptide binding]; other site 1052588006296 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1052588006297 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052588006298 dimer interface [polypeptide binding]; other site 1052588006299 phosphorylation site [posttranslational modification] 1052588006300 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588006301 ATP binding site [chemical binding]; other site 1052588006302 Mg2+ binding site [ion binding]; other site 1052588006303 G-X-G motif; other site 1052588006304 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052588006305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588006306 active site 1052588006307 phosphorylation site [posttranslational modification] 1052588006308 intermolecular recognition site; other site 1052588006309 dimerization interface [polypeptide binding]; other site 1052588006310 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052588006311 DNA binding site [nucleotide binding] 1052588006312 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1052588006313 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1052588006314 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1052588006315 ResB-like family; Region: ResB; pfam05140 1052588006316 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1052588006317 catalytic residues [active] 1052588006318 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1052588006319 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1052588006320 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1052588006321 active site 1052588006322 Nucleoside recognition; Region: Gate; cl00486 1052588006323 Nucleoside recognition; Region: Gate; cl00486 1052588006324 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1052588006325 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052588006326 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 1052588006327 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 1052588006328 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 1052588006329 ScpA/B protein; Region: ScpA_ScpB; cl00598 1052588006330 Domain of unknown function (DUF309); Region: DUF309; cl00667 1052588006331 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588006332 Coenzyme A binding pocket [chemical binding]; other site 1052588006333 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1052588006334 homopentamer interface [polypeptide binding]; other site 1052588006335 active site 1052588006336 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1052588006337 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 1052588006338 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1052588006339 dimerization interface [polypeptide binding]; other site 1052588006340 active site 1052588006341 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1052588006342 Lumazine binding domain; Region: Lum_binding; pfam00677 1052588006343 Lumazine binding domain; Region: Lum_binding; pfam00677 1052588006344 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1052588006345 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1052588006346 catalytic motif [active] 1052588006347 Zn binding site [ion binding]; other site 1052588006348 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1052588006349 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1052588006350 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1052588006351 Catalytic site [active] 1052588006352 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381 1052588006353 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1052588006354 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1052588006355 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1052588006356 active site 1052588006357 Bacterial SH3 domain; Region: SH3_3; cl02551 1052588006358 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1052588006359 active site 1052588006360 Predicted secreted protein [Function unknown]; Region: COG4086 1052588006361 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1052588006362 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1052588006363 active site 1052588006364 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1052588006365 substrate binding site [chemical binding]; other site 1052588006366 catalytic residues [active] 1052588006367 dimer interface [polypeptide binding]; other site 1052588006368 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1052588006369 stage V sporulation protein AD; Validated; Region: PRK08304 1052588006370 stage V sporulation protein AD; Provisional; Region: PRK12404 1052588006371 SpoVA protein; Region: SpoVA; cl04298 1052588006372 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 1052588006373 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 1052588006374 sporulation sigma factor SigF; Validated; Region: PRK05572 1052588006375 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052588006376 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1052588006377 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588006378 DNA binding residues [nucleotide binding] 1052588006379 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1052588006380 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588006381 ATP binding site [chemical binding]; other site 1052588006382 Mg2+ binding site [ion binding]; other site 1052588006383 G-X-G motif; other site 1052588006384 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 1052588006385 Sulfatase; Region: Sulfatase; cl10460 1052588006386 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1052588006387 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1052588006388 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1052588006389 active site 1052588006390 Int/Topo IB signature motif; other site 1052588006391 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 1052588006392 ferric uptake regulator; Provisional; Region: fur; PRK09462 1052588006393 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1052588006394 metal binding site 2 [ion binding]; metal-binding site 1052588006395 putative DNA binding helix; other site 1052588006396 metal binding site 1 [ion binding]; metal-binding site 1052588006397 dimer interface [polypeptide binding]; other site 1052588006398 structural Zn2+ binding site [ion binding]; other site 1052588006399 Integral membrane protein DUF95; Region: DUF95; cl00572 1052588006400 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1052588006401 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1052588006402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588006403 NAD(P) binding pocket [chemical binding]; other site 1052588006404 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1052588006405 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1052588006406 Aspartase; Region: Aspartase; cd01357 1052588006407 active sites [active] 1052588006408 tetramer interface [polypeptide binding]; other site 1052588006409 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1052588006410 active site 1052588006411 homodimer interface [polypeptide binding]; other site 1052588006412 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1052588006413 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052588006414 non-specific DNA binding site [nucleotide binding]; other site 1052588006415 salt bridge; other site 1052588006416 sequence-specific DNA binding site [nucleotide binding]; other site 1052588006417 TIGR00375 family protein; Region: TIGR00375 1052588006418 PHP-associated; Region: PHP_C; pfam13263 1052588006419 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1052588006420 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1052588006421 dimer interface [polypeptide binding]; other site 1052588006422 ADP-ribose binding site [chemical binding]; other site 1052588006423 active site 1052588006424 nudix motif; other site 1052588006425 metal binding site [ion binding]; metal-binding site 1052588006426 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 1052588006427 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1052588006428 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052588006429 active site 1052588006430 catalytic tetrad [active] 1052588006431 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1052588006432 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052588006433 Eukaryotic protein of unknown function (DUF829); Region: DUF829; pfam05705 1052588006434 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 1052588006435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1052588006436 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588006437 putative acetyltransferase; Provisional; Region: PRK03624 1052588006438 Coenzyme A binding pocket [chemical binding]; other site 1052588006439 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 1052588006440 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1052588006441 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1052588006442 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588006443 Coenzyme A binding pocket [chemical binding]; other site 1052588006444 YolD-like protein; Region: YolD; pfam08863 1052588006445 DNA polymerase IV; Reviewed; Region: PRK03103 1052588006446 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1052588006447 active site 1052588006448 DNA binding site [nucleotide binding] 1052588006449 YqzH-like protein; Region: YqzH; pfam14164 1052588006450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588006451 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588006452 putative substrate translocation pore; other site 1052588006453 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1052588006454 putative dimer interface [polypeptide binding]; other site 1052588006455 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052588006456 ligand binding site [chemical binding]; other site 1052588006457 Zn binding site [ion binding]; other site 1052588006458 pantothenate kinase; Provisional; Region: PRK05439 1052588006459 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 1052588006460 ATP-binding site [chemical binding]; other site 1052588006461 CoA-binding site [chemical binding]; other site 1052588006462 Mg2+-binding site [ion binding]; other site 1052588006463 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1052588006464 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1052588006465 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052588006466 catalytic residue [active] 1052588006467 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1052588006468 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332 1052588006469 NADP binding site [chemical binding]; other site 1052588006470 homodimer interface [polypeptide binding]; other site 1052588006471 substrate binding site [chemical binding]; other site 1052588006472 active site 1052588006473 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1052588006474 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052588006475 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588006476 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1052588006477 Arginine degradation protein (predicted deacylase) [Amino acid transport and metabolism]; Region: RocB; COG4187 1052588006478 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 1052588006479 putative metal binding site [ion binding]; other site 1052588006480 putative dimer interface [polypeptide binding]; other site 1052588006481 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1052588006482 active site 1052588006483 FMN binding site [chemical binding]; other site 1052588006484 substrate binding site [chemical binding]; other site 1052588006485 homotetramer interface [polypeptide binding]; other site 1052588006486 catalytic residue [active] 1052588006487 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052588006488 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 1052588006489 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052588006490 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1052588006491 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1052588006492 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1052588006493 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588006494 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1052588006495 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1052588006496 DNA polymerase IV; Validated; Region: PRK01810 1052588006497 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1052588006498 active site 1052588006499 DNA binding site [nucleotide binding] 1052588006500 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1052588006501 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1052588006502 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 1052588006503 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1052588006504 peptidase T-like protein; Region: PepT-like; TIGR01883 1052588006505 metal binding site [ion binding]; metal-binding site 1052588006506 putative dimer interface [polypeptide binding]; other site 1052588006507 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 1052588006508 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1052588006509 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1052588006510 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052588006511 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1052588006512 dimer interface [polypeptide binding]; other site 1052588006513 substrate binding site [chemical binding]; other site 1052588006514 metal binding site [ion binding]; metal-binding site 1052588006515 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 1052588006516 Predicted membrane protein [Function unknown]; Region: COG4129 1052588006517 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 1052588006518 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1052588006519 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1052588006520 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1052588006521 Walker A/P-loop; other site 1052588006522 ATP binding site [chemical binding]; other site 1052588006523 Q-loop/lid; other site 1052588006524 ABC transporter signature motif; other site 1052588006525 Walker B; other site 1052588006526 D-loop; other site 1052588006527 H-loop/switch region; other site 1052588006528 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1052588006529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588006530 dimer interface [polypeptide binding]; other site 1052588006531 conserved gate region; other site 1052588006532 putative PBP binding loops; other site 1052588006533 ABC-ATPase subunit interface; other site 1052588006534 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1052588006535 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1052588006536 substrate binding pocket [chemical binding]; other site 1052588006537 membrane-bound complex binding site; other site 1052588006538 hinge residues; other site 1052588006539 Disulphide isomerase; Region: Disulph_isomer; cl05813 1052588006540 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1052588006541 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1052588006542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588006543 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588006544 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1052588006545 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1052588006546 DNA binding residues [nucleotide binding] 1052588006547 drug binding residues [chemical binding]; other site 1052588006548 dimer interface [polypeptide binding]; other site 1052588006549 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1052588006550 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1052588006551 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1052588006552 E3 interaction surface; other site 1052588006553 lipoyl attachment site [posttranslational modification]; other site 1052588006554 e3 binding domain; Region: E3_binding; pfam02817 1052588006555 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 1052588006556 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1052588006557 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1052588006558 alpha subunit interface [polypeptide binding]; other site 1052588006559 TPP binding site [chemical binding]; other site 1052588006560 heterodimer interface [polypeptide binding]; other site 1052588006561 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1052588006562 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1052588006563 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1052588006564 tetramer interface [polypeptide binding]; other site 1052588006565 TPP-binding site [chemical binding]; other site 1052588006566 heterodimer interface [polypeptide binding]; other site 1052588006567 phosphorylation loop region [posttranslational modification] 1052588006568 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1052588006569 glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Region: glycerol3P_GlpB; TIGR03378 1052588006570 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052588006571 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1052588006572 Acetokinase family; Region: Acetate_kinase; cl01029 1052588006573 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1052588006574 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1052588006575 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1052588006576 NAD binding site [chemical binding]; other site 1052588006577 Phe binding site; other site 1052588006578 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1052588006579 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 1052588006580 acetaldehyde dehydrogenase (acetylating); Region: ac_ald_DH_ac; TIGR03215 1052588006581 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1052588006582 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052588006583 putative active site [active] 1052588006584 heme pocket [chemical binding]; other site 1052588006585 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1052588006586 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588006587 Walker A motif; other site 1052588006588 ATP binding site [chemical binding]; other site 1052588006589 Walker B motif; other site 1052588006590 arginine finger; other site 1052588006591 Helix-turn-helix domains; Region: HTH; cl00088 1052588006592 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 1052588006593 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 1052588006594 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1052588006595 tetramer interface [polypeptide binding]; other site 1052588006596 active site 1052588006597 Mg2+/Mn2+ binding site [ion binding]; other site 1052588006598 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1052588006599 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 1052588006600 dimer interface [polypeptide binding]; other site 1052588006601 Citrate synthase; Region: Citrate_synt; pfam00285 1052588006602 active site 1052588006603 coenzyme A binding site [chemical binding]; other site 1052588006604 citrylCoA binding site [chemical binding]; other site 1052588006605 oxalacetate/citrate binding site [chemical binding]; other site 1052588006606 catalytic triad [active] 1052588006607 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1052588006608 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1052588006609 FAD binding site [chemical binding]; other site 1052588006610 homotetramer interface [polypeptide binding]; other site 1052588006611 substrate binding pocket [chemical binding]; other site 1052588006612 catalytic base [active] 1052588006613 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1052588006614 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588006615 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1052588006616 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 1052588006617 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1052588006618 dimer interface [polypeptide binding]; other site 1052588006619 active site 1052588006620 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1052588006621 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1052588006622 active site 1052588006623 catalytic site [active] 1052588006624 metal binding site [ion binding]; metal-binding site 1052588006625 dimer interface [polypeptide binding]; other site 1052588006626 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 1052588006627 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1052588006628 active site 1052588006629 metal binding site [ion binding]; metal-binding site 1052588006630 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1052588006631 putative active site [active] 1052588006632 putative FMN binding site [chemical binding]; other site 1052588006633 putative substrate binding site [chemical binding]; other site 1052588006634 putative catalytic residue [active] 1052588006635 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 1052588006636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588006637 active site 1052588006638 phosphorylation site [posttranslational modification] 1052588006639 intermolecular recognition site; other site 1052588006640 dimerization interface [polypeptide binding]; other site 1052588006641 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 1052588006642 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 1052588006643 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1052588006644 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 1052588006645 DNA repair protein RecN; Region: recN; TIGR00634 1052588006646 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 1052588006647 Walker A/P-loop; other site 1052588006648 ATP binding site [chemical binding]; other site 1052588006649 Q-loop/lid; other site 1052588006650 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 1052588006651 ABC transporter signature motif; other site 1052588006652 Walker B; other site 1052588006653 D-loop; other site 1052588006654 H-loop/switch region; other site 1052588006655 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1052588006656 arginine repressor; Provisional; Region: PRK04280 1052588006657 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1052588006658 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1052588006659 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052588006660 RNA binding surface [nucleotide binding]; other site 1052588006661 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1052588006662 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 1052588006663 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1052588006664 TPP-binding site; other site 1052588006665 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1052588006666 PYR/PP interface [polypeptide binding]; other site 1052588006667 dimer interface [polypeptide binding]; other site 1052588006668 TPP binding site [chemical binding]; other site 1052588006669 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1052588006670 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1052588006671 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1052588006672 substrate binding pocket [chemical binding]; other site 1052588006673 chain length determination region; other site 1052588006674 substrate-Mg2+ binding site; other site 1052588006675 catalytic residues [active] 1052588006676 aspartate-rich region 1; other site 1052588006677 active site lid residues [active] 1052588006678 aspartate-rich region 2; other site 1052588006679 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 1052588006680 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 1052588006681 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1052588006682 generic binding surface II; other site 1052588006683 generic binding surface I; other site 1052588006684 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1052588006685 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1052588006686 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1052588006687 homodimer interface [polypeptide binding]; other site 1052588006688 NADP binding site [chemical binding]; other site 1052588006689 substrate binding site [chemical binding]; other site 1052588006690 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1052588006691 putative RNA binding site [nucleotide binding]; other site 1052588006692 Asp23 family; Region: Asp23; cl00574 1052588006693 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1052588006694 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052588006695 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1052588006696 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1052588006697 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1052588006698 carboxyltransferase (CT) interaction site; other site 1052588006699 biotinylation site [posttranslational modification]; other site 1052588006700 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 1052588006701 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 1052588006702 stage III sporulation protein AF; Region: spore_III_AF; TIGR02896 1052588006703 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 1052588006704 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 1052588006705 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 1052588006706 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 1052588006707 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 1052588006708 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 1052588006709 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588006710 Walker A motif; other site 1052588006711 ATP binding site [chemical binding]; other site 1052588006712 Walker B motif; other site 1052588006713 arginine finger; other site 1052588006714 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 1052588006715 elongation factor P; Validated; Region: PRK00529 1052588006716 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1052588006717 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1052588006718 RNA binding site [nucleotide binding]; other site 1052588006719 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1052588006720 RNA binding site [nucleotide binding]; other site 1052588006721 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1052588006722 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1052588006723 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1052588006724 active site 1052588006725 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1052588006726 trimer interface [polypeptide binding]; other site 1052588006727 active site 1052588006728 dimer interface [polypeptide binding]; other site 1052588006729 Conserved membrane protein YqhR; Region: YqhR; pfam11085 1052588006730 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 1052588006731 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1052588006732 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1052588006733 active site 1052588006734 nucleophile elbow; other site 1052588006735 manganese transport transcriptional regulator; Provisional; Region: PRK03902 1052588006736 Helix-turn-helix domains; Region: HTH; cl00088 1052588006737 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1052588006738 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1052588006739 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1052588006740 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1052588006741 active site residue [active] 1052588006742 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 1052588006743 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1052588006744 tetramer interface [polypeptide binding]; other site 1052588006745 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588006746 catalytic residue [active] 1052588006747 glycine dehydrogenase subunit 1; Validated; Region: PRK00451 1052588006748 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1052588006749 tetramer interface [polypeptide binding]; other site 1052588006750 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588006751 catalytic residue [active] 1052588006752 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1052588006753 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1052588006754 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1052588006755 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1052588006756 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052588006757 ATP binding site [chemical binding]; other site 1052588006758 putative Mg++ binding site [ion binding]; other site 1052588006759 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052588006760 nucleotide binding region [chemical binding]; other site 1052588006761 ATP-dependent helicase HepA; Validated; Region: PRK04914 1052588006762 ATP-binding site [chemical binding]; other site 1052588006763 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 1052588006764 Anti-repressor SinI; Region: SinI; pfam08671 1052588006765 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052588006766 non-specific DNA binding site [nucleotide binding]; other site 1052588006767 salt bridge; other site 1052588006768 sequence-specific DNA binding site [nucleotide binding]; other site 1052588006769 Anti-repressor SinI; Region: SinI; pfam08671 1052588006770 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 1052588006771 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1052588006772 Catalytic site [active] 1052588006773 YqxM protein; Region: YqxM_for_SipW; TIGR04087 1052588006774 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1052588006775 YqzE-like protein; Region: YqzE; pfam14038 1052588006776 ComG operon protein 7; Region: ComGG; pfam14173 1052588006777 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1052588006778 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1052588006779 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 1052588006780 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 1052588006781 Type II/IV secretion system protein; Region: T2SE; pfam00437 1052588006782 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1052588006783 Walker A motif; other site 1052588006784 ATP binding site [chemical binding]; other site 1052588006785 Walker B motif; other site 1052588006786 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1052588006787 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 1052588006788 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1052588006789 Domain of unknown function DUF21; Region: DUF21; pfam01595 1052588006790 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1052588006791 Transporter associated domain; Region: CorC_HlyC; cl08393 1052588006792 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1052588006793 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1052588006794 ArsC family; Region: ArsC; pfam03960 1052588006795 putative catalytic residues [active] 1052588006796 thiol/disulfide switch; other site 1052588006797 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 1052588006798 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052588006799 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 1052588006800 Domain of unknown function DUF77; Region: DUF77; cl00307 1052588006801 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1052588006802 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 1052588006803 putative active site [active] 1052588006804 Zn binding site [ion binding]; other site 1052588006805 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1052588006806 Sulfatase; Region: Sulfatase; cl10460 1052588006807 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1052588006808 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1052588006809 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 1052588006810 Rhomboid family; Region: Rhomboid; cl11446 1052588006811 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588006812 binding surface 1052588006813 TPR motif; other site 1052588006814 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 1052588006815 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1052588006816 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1052588006817 proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675 1052588006818 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274 1052588006819 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 1052588006820 Walker A/P-loop; other site 1052588006821 ATP binding site [chemical binding]; other site 1052588006822 Q-loop/lid; other site 1052588006823 ABC transporter signature motif; other site 1052588006824 Walker B; other site 1052588006825 D-loop; other site 1052588006826 H-loop/switch region; other site 1052588006827 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248 1052588006828 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 1052588006829 Walker A/P-loop; other site 1052588006830 ATP binding site [chemical binding]; other site 1052588006831 Q-loop/lid; other site 1052588006832 ABC transporter signature motif; other site 1052588006833 Walker B; other site 1052588006834 D-loop; other site 1052588006835 H-loop/switch region; other site 1052588006836 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1052588006837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588006838 dimer interface [polypeptide binding]; other site 1052588006839 conserved gate region; other site 1052588006840 ABC-ATPase subunit interface; other site 1052588006841 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1052588006842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588006843 dimer interface [polypeptide binding]; other site 1052588006844 conserved gate region; other site 1052588006845 putative PBP binding loops; other site 1052588006846 ABC-ATPase subunit interface; other site 1052588006847 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1052588006848 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1052588006849 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1052588006850 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1052588006851 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052588006852 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588006853 putative substrate translocation pore; other site 1052588006854 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1052588006855 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1052588006856 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1052588006857 Protein of unknown function (DUF456); Region: DUF456; cl01069 1052588006858 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 1052588006859 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 1052588006860 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1052588006861 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1052588006862 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1052588006863 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1052588006864 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1052588006865 ferric uptake regulator; Provisional; Region: fur; PRK09462 1052588006866 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1052588006867 metal binding site 2 [ion binding]; metal-binding site 1052588006868 putative DNA binding helix; other site 1052588006869 metal binding site 1 [ion binding]; metal-binding site 1052588006870 dimer interface [polypeptide binding]; other site 1052588006871 structural Zn2+ binding site [ion binding]; other site 1052588006872 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1052588006873 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052588006874 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052588006875 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 1052588006876 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 1052588006877 endonuclease IV; Provisional; Region: PRK01060 1052588006878 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1052588006879 AP (apurinic/apyrimidinic) site pocket; other site 1052588006880 DNA interaction; other site 1052588006881 Metal-binding active site; metal-binding site 1052588006882 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1052588006883 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1052588006884 ATP binding site [chemical binding]; other site 1052588006885 Mg++ binding site [ion binding]; other site 1052588006886 motif III; other site 1052588006887 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052588006888 nucleotide binding region [chemical binding]; other site 1052588006889 ATP-binding site [chemical binding]; other site 1052588006890 YqfQ-like protein; Region: YqfQ; pfam14181 1052588006891 LytB protein; Region: LYTB; cl00507 1052588006892 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 1052588006893 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1052588006894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1052588006895 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1052588006896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1052588006897 Cytochrome c; Region: Cytochrom_C; cl11414 1052588006898 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1052588006899 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1052588006900 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1052588006901 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052588006902 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1052588006903 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588006904 DNA binding residues [nucleotide binding] 1052588006905 DNA primase; Validated; Region: dnaG; PRK05667 1052588006906 CHC2 zinc finger; Region: zf-CHC2; cl15369 1052588006907 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1052588006908 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1052588006909 active site 1052588006910 metal binding site [ion binding]; metal-binding site 1052588006911 interdomain interaction site; other site 1052588006912 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1052588006913 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 1052588006914 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 1052588006915 Helix-turn-helix domains; Region: HTH; cl00088 1052588006916 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1052588006917 FOG: CBS domain [General function prediction only]; Region: COG0517 1052588006918 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 1052588006919 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1052588006920 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1052588006921 dimer interface [polypeptide binding]; other site 1052588006922 motif 1; other site 1052588006923 active site 1052588006924 motif 2; other site 1052588006925 motif 3; other site 1052588006926 Recombination protein O N terminal; Region: RecO_N; cl15812 1052588006927 DNA repair protein RecO; Region: reco; TIGR00613 1052588006928 Recombination protein O C terminal; Region: RecO_C; pfam02565 1052588006929 YqzL-like protein; Region: YqzL; pfam14006 1052588006930 GTPase Era; Reviewed; Region: era; PRK00089 1052588006931 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1052588006932 G1 box; other site 1052588006933 GTP/Mg2+ binding site [chemical binding]; other site 1052588006934 Switch I region; other site 1052588006935 G2 box; other site 1052588006936 Switch II region; other site 1052588006937 G3 box; other site 1052588006938 G4 box; other site 1052588006939 G5 box; other site 1052588006940 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 1052588006941 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1052588006942 active site 1052588006943 catalytic motif [active] 1052588006944 Zn binding site [ion binding]; other site 1052588006945 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 1052588006946 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 1052588006947 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1052588006948 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 1052588006949 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052588006950 Zn2+ binding site [ion binding]; other site 1052588006951 Mg2+ binding site [ion binding]; other site 1052588006952 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1052588006953 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588006954 YabP family; Region: YabP; cl06766 1052588006955 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 1052588006956 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1052588006957 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 1052588006958 dimer interface [polypeptide binding]; other site 1052588006959 active site residues [active] 1052588006960 GatB domain; Region: GatB_Yqey; cl11497 1052588006961 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 1052588006962 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 1052588006963 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1052588006964 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1052588006965 radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089 1052588006966 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1052588006967 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052588006968 FeS/SAM binding site; other site 1052588006969 TRAM domain; Region: TRAM; cl01282 1052588006970 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 1052588006971 RNA methyltransferase, RsmE family; Region: TIGR00046 1052588006972 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 1052588006973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588006974 S-adenosylmethionine binding site [chemical binding]; other site 1052588006975 chaperone protein DnaJ; Provisional; Region: PRK14280 1052588006976 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1052588006977 HSP70 interaction site [polypeptide binding]; other site 1052588006978 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1052588006979 substrate binding site [polypeptide binding]; other site 1052588006980 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1052588006981 Zn binding sites [ion binding]; other site 1052588006982 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1052588006983 dimer interface [polypeptide binding]; other site 1052588006984 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1052588006985 lumazine synthase and riboflavin synthase; involved in the riboflavin (vitamin B2) biosynthetic pathway; Region: Lumazine_synthase-like; cl00317 1052588006986 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1052588006987 dimer interface [polypeptide binding]; other site 1052588006988 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1052588006989 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1052588006990 Helix-turn-helix domains; Region: HTH; cl00088 1052588006991 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1052588006992 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052588006993 FeS/SAM binding site; other site 1052588006994 HemN C-terminal domain; Region: HemN_C; pfam06969 1052588006995 GTP-binding protein LepA; Provisional; Region: PRK05433 1052588006996 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1052588006997 G1 box; other site 1052588006998 putative GEF interaction site [polypeptide binding]; other site 1052588006999 GTP/Mg2+ binding site [chemical binding]; other site 1052588007000 Switch I region; other site 1052588007001 G2 box; other site 1052588007002 G3 box; other site 1052588007003 Switch II region; other site 1052588007004 G4 box; other site 1052588007005 G5 box; other site 1052588007006 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1052588007007 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1052588007008 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1052588007009 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 1052588007010 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 1052588007011 stage II sporulation protein P; Region: spore_II_P; TIGR02867 1052588007012 Germination protease; Region: Peptidase_A25; cl04057 1052588007013 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 1052588007014 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1052588007015 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1052588007016 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1052588007017 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 1052588007018 Competence protein; Region: Competence; cl00471 1052588007019 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052588007020 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1052588007021 catalytic motif [active] 1052588007022 Zn binding site [ion binding]; other site 1052588007023 SLBB domain; Region: SLBB; pfam10531 1052588007024 comEA protein; Region: comE; TIGR01259 1052588007025 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1052588007026 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588007027 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1052588007028 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1052588007029 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588007030 S-adenosylmethionine binding site [chemical binding]; other site 1052588007031 Oligomerisation domain; Region: Oligomerisation; cl00519 1052588007032 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 1052588007033 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052588007034 Zn2+ binding site [ion binding]; other site 1052588007035 Mg2+ binding site [ion binding]; other site 1052588007036 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1052588007037 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1052588007038 active site 1052588007039 (T/H)XGH motif; other site 1052588007040 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 1052588007041 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 1052588007042 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1052588007043 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1052588007044 shikimate binding site; other site 1052588007045 NAD(P) binding site [chemical binding]; other site 1052588007046 GTPase YqeH; Provisional; Region: PRK13796 1052588007047 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1052588007048 GTP/Mg2+ binding site [chemical binding]; other site 1052588007049 G4 box; other site 1052588007050 G5 box; other site 1052588007051 G1 box; other site 1052588007052 Switch I region; other site 1052588007053 G2 box; other site 1052588007054 G3 box; other site 1052588007055 Switch II region; other site 1052588007056 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1052588007057 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588007058 active site 1052588007059 motif I; other site 1052588007060 motif II; other site 1052588007061 Sporulation inhibitor A; Region: Sda; pfam08970 1052588007062 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1052588007063 active site 1052588007064 catalytic triad [active] 1052588007065 oxyanion hole [active] 1052588007066 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1052588007067 amidase catalytic site [active] 1052588007068 Zn binding residues [ion binding]; other site 1052588007069 substrate binding site [chemical binding]; other site 1052588007070 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1052588007071 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1052588007072 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 1052588007073 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588007074 arginine decarboxylase; Provisional; Region: PRK15029 1052588007075 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1052588007076 sporulation sigma factor SigK; Reviewed; Region: PRK05803 1052588007077 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052588007078 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588007079 DNA binding residues [nucleotide binding] 1052588007080 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1052588007081 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1052588007082 Helix-turn-helix domains; Region: HTH; cl00088 1052588007083 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1052588007084 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052588007085 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052588007086 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1052588007087 dimerization domain swap beta strand [polypeptide binding]; other site 1052588007088 regulatory protein interface [polypeptide binding]; other site 1052588007089 regulatory phosphorylation site [posttranslational modification]; other site 1052588007090 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1052588007091 classical (c) SDRs; Region: SDR_c; cd05233 1052588007092 NAD(P) binding site [chemical binding]; other site 1052588007093 active site 1052588007094 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052588007095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588007096 putative substrate translocation pore; other site 1052588007097 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1052588007098 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1052588007099 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052588007100 active site 1052588007101 catalytic tetrad [active] 1052588007102 Cupin domain; Region: Cupin_2; cl09118 1052588007103 Cyclophilin-like; Region: Cyclophil_like; cl00950 1052588007104 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052588007105 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052588007106 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588007107 binding surface 1052588007108 TPR motif; other site 1052588007109 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052588007110 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1052588007111 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 1052588007112 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1052588007113 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1052588007114 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1052588007115 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1052588007116 Helix-turn-helix domains; Region: HTH; cl00088 1052588007117 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1052588007118 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 1052588007119 DNA binding residues [nucleotide binding] 1052588007120 dimer interface [polypeptide binding]; other site 1052588007121 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1052588007122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588007123 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588007124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588007125 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052588007126 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1052588007127 Domain of unknown function DUF21; Region: DUF21; pfam01595 1052588007128 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1052588007129 Transporter associated domain; Region: CorC_HlyC; cl08393 1052588007130 YrzO-like protein; Region: YrzO; pfam14142 1052588007131 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1052588007132 RNAase interaction site [polypeptide binding]; other site 1052588007133 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1052588007134 Isochorismatase family; Region: Isochorismatase; pfam00857 1052588007135 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1052588007136 catalytic triad [active] 1052588007137 conserved cis-peptide bond; other site 1052588007138 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1052588007139 DinB superfamily; Region: DinB_2; pfam12867 1052588007140 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 1052588007141 Nitronate monooxygenase; Region: NMO; pfam03060 1052588007142 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1052588007143 FMN binding site [chemical binding]; other site 1052588007144 substrate binding site [chemical binding]; other site 1052588007145 putative catalytic residue [active] 1052588007146 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1052588007147 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052588007148 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588007149 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1052588007150 dimer interface [polypeptide binding]; other site 1052588007151 FMN binding site [chemical binding]; other site 1052588007152 NADPH bind site [chemical binding]; other site 1052588007153 Helix-turn-helix domains; Region: HTH; cl00088 1052588007154 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588007155 Flavin Reductases; Region: FlaRed; cl00801 1052588007156 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1052588007157 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1052588007158 DNA binding residues [nucleotide binding] 1052588007159 drug binding residues [chemical binding]; other site 1052588007160 dimer interface [polypeptide binding]; other site 1052588007161 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1052588007162 Protein of unknown function (DUF419); Region: DUF419; cl15265 1052588007163 YodA lipocalin-like domain; Region: YodA; cl01365 1052588007164 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 1052588007165 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052588007166 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588007167 DNA binding residues [nucleotide binding] 1052588007168 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1052588007169 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052588007170 active site 1052588007171 catalytic tetrad [active] 1052588007172 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 1052588007173 chitosan binding site [chemical binding]; other site 1052588007174 catalytic residues [active] 1052588007175 Mor transcription activator family; Region: Mor; cl02360 1052588007176 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052588007177 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052588007178 Bacterial SH3 domain; Region: SH3_3; cl02551 1052588007179 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 1052588007180 Bacterial SH3 domain; Region: SH3_3; cl02551 1052588007181 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052588007182 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1052588007183 active site 1052588007184 metal binding site [ion binding]; metal-binding site 1052588007185 Coat F domain; Region: Coat_F; cl15836 1052588007186 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1052588007187 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1052588007188 NAD binding site [chemical binding]; other site 1052588007189 catalytic Zn binding site [ion binding]; other site 1052588007190 structural Zn binding site [ion binding]; other site 1052588007191 Coat F domain; Region: Coat_F; cl15836 1052588007192 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1052588007193 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1052588007194 DNA binding residues [nucleotide binding] 1052588007195 putative dimer interface [polypeptide binding]; other site 1052588007196 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1052588007197 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1052588007198 putative NAD(P) binding site [chemical binding]; other site 1052588007199 putative substrate binding site [chemical binding]; other site 1052588007200 catalytic Zn binding site [ion binding]; other site 1052588007201 structural Zn binding site [ion binding]; other site 1052588007202 dimer interface [polypeptide binding]; other site 1052588007203 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1052588007204 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1052588007205 proposed catalytic triad [active] 1052588007206 conserved cys residue [active] 1052588007207 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 1052588007208 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1052588007209 substrate binding [chemical binding]; other site 1052588007210 active site 1052588007211 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1052588007212 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 1052588007213 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 1052588007214 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 1052588007215 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1052588007216 active site 1052588007217 phosphorylation site [posttranslational modification] 1052588007218 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1052588007219 active pocket/dimerization site; other site 1052588007220 active site 1052588007221 phosphorylation site [posttranslational modification] 1052588007222 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1052588007223 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588007224 Walker A motif; other site 1052588007225 ATP binding site [chemical binding]; other site 1052588007226 Walker B motif; other site 1052588007227 arginine finger; other site 1052588007228 Transcriptional antiterminator [Transcription]; Region: COG3933 1052588007229 PRD domain; Region: PRD; cl15445 1052588007230 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1052588007231 active pocket/dimerization site; other site 1052588007232 active site 1052588007233 phosphorylation site [posttranslational modification] 1052588007234 PRD domain; Region: PRD; cl15445 1052588007235 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1052588007236 LysE type translocator; Region: LysE; cl00565 1052588007237 Predicted transcriptional regulators [Transcription]; Region: COG1378 1052588007238 Helix-turn-helix domains; Region: HTH; cl00088 1052588007239 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 1052588007240 C-terminal domain interface [polypeptide binding]; other site 1052588007241 sugar binding site [chemical binding]; other site 1052588007242 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1052588007243 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052588007244 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588007245 DNA binding residues [nucleotide binding] 1052588007246 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1052588007247 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1052588007248 OpgC protein; Region: OpgC_C; cl00792 1052588007249 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1052588007250 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1052588007251 catalytic triad [active] 1052588007252 catalytic triad [active] 1052588007253 oxyanion hole [active] 1052588007254 YrhK-like protein; Region: YrhK; pfam14145 1052588007255 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1052588007256 Cytochrome P450; Region: p450; pfam00067 1052588007257 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1052588007258 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1052588007259 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1052588007260 FAD binding pocket [chemical binding]; other site 1052588007261 FAD binding motif [chemical binding]; other site 1052588007262 catalytic residues [active] 1052588007263 NAD binding pocket [chemical binding]; other site 1052588007264 phosphate binding motif [ion binding]; other site 1052588007265 beta-alpha-beta structure motif; other site 1052588007266 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052588007267 Helix-turn-helix domains; Region: HTH; cl00088 1052588007268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588007269 S-adenosylmethionine binding site [chemical binding]; other site 1052588007270 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 1052588007271 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 1052588007272 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 1052588007273 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1052588007274 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1052588007275 catalytic loop [active] 1052588007276 iron binding site [ion binding]; other site 1052588007277 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 1052588007278 4Fe-4S binding domain; Region: Fer4; cl02805 1052588007279 4Fe-4S binding domain; Region: Fer4; cl02805 1052588007280 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1052588007281 [4Fe-4S] binding site [ion binding]; other site 1052588007282 molybdopterin cofactor binding site; other site 1052588007283 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1052588007284 molybdopterin cofactor binding site; other site 1052588007285 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 1052588007286 YrhC-like protein; Region: YrhC; pfam14143 1052588007287 cystathionine beta-lyase; Provisional; Region: PRK07671 1052588007288 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1052588007289 homodimer interface [polypeptide binding]; other site 1052588007290 substrate-cofactor binding pocket; other site 1052588007291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588007292 catalytic residue [active] 1052588007293 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1052588007294 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1052588007295 dimer interface [polypeptide binding]; other site 1052588007296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588007297 catalytic residue [active] 1052588007298 5'-methylthioadenosine nucleosidase; Region: PLN02584 1052588007299 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1052588007300 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1052588007301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588007302 S-adenosylmethionine binding site [chemical binding]; other site 1052588007303 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 1052588007304 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1052588007305 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1052588007306 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1052588007307 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052588007308 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1052588007309 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1052588007310 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1052588007311 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1052588007312 ATP-binding site [chemical binding]; other site 1052588007313 Sugar specificity; other site 1052588007314 Pyrimidine base specificity; other site 1052588007315 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1052588007316 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1052588007317 Peptidase family U32; Region: Peptidase_U32; cl03113 1052588007318 Peptidase family U32; Region: Peptidase_U32; cl03113 1052588007319 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1052588007320 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588007321 S-adenosylmethionine binding site [chemical binding]; other site 1052588007322 YceG-like family; Region: YceG; pfam02618 1052588007323 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1052588007324 dimerization interface [polypeptide binding]; other site 1052588007325 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 1052588007326 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 1052588007327 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 1052588007328 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1052588007329 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 1052588007330 motif 1; other site 1052588007331 active site 1052588007332 motif 2; other site 1052588007333 motif 3; other site 1052588007334 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 1052588007335 DHHA1 domain; Region: DHHA1; pfam02272 1052588007336 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1052588007337 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1052588007338 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1052588007339 Walker A/P-loop; other site 1052588007340 ATP binding site [chemical binding]; other site 1052588007341 Q-loop/lid; other site 1052588007342 ABC transporter signature motif; other site 1052588007343 Walker B; other site 1052588007344 D-loop; other site 1052588007345 H-loop/switch region; other site 1052588007346 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1052588007347 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1052588007348 substrate binding pocket [chemical binding]; other site 1052588007349 membrane-bound complex binding site; other site 1052588007350 hinge residues; other site 1052588007351 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1052588007352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588007353 dimer interface [polypeptide binding]; other site 1052588007354 conserved gate region; other site 1052588007355 putative PBP binding loops; other site 1052588007356 ABC-ATPase subunit interface; other site 1052588007357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1052588007358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588007359 dimer interface [polypeptide binding]; other site 1052588007360 ABC-ATPase subunit interface; other site 1052588007361 putative PBP binding loops; other site 1052588007362 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 1052588007363 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 1052588007364 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1052588007365 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588007366 Family description; Region: UvrD_C_2; cl15862 1052588007367 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588007368 binding surface 1052588007369 TPR motif; other site 1052588007370 TPR repeat; Region: TPR_11; pfam13414 1052588007371 TPR repeat; Region: TPR_11; pfam13414 1052588007372 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588007373 binding surface 1052588007374 TPR motif; other site 1052588007375 TPR repeat; Region: TPR_11; pfam13414 1052588007376 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1052588007377 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1052588007378 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1052588007379 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 1052588007380 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052588007381 catalytic residue [active] 1052588007382 Predicted transcriptional regulator [Transcription]; Region: COG1959 1052588007383 Helix-turn-helix domains; Region: HTH; cl00088 1052588007384 recombination factor protein RarA; Reviewed; Region: PRK13342 1052588007385 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588007386 Walker A motif; other site 1052588007387 ATP binding site [chemical binding]; other site 1052588007388 Walker B motif; other site 1052588007389 arginine finger; other site 1052588007390 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1052588007391 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1052588007392 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1052588007393 putative ATP binding site [chemical binding]; other site 1052588007394 putative substrate interface [chemical binding]; other site 1052588007395 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1052588007396 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1052588007397 dimer interface [polypeptide binding]; other site 1052588007398 anticodon binding site; other site 1052588007399 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 1052588007400 homodimer interface [polypeptide binding]; other site 1052588007401 motif 1; other site 1052588007402 active site 1052588007403 motif 2; other site 1052588007404 GAD domain; Region: GAD; pfam02938 1052588007405 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 1052588007406 motif 3; other site 1052588007407 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1052588007408 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 1052588007409 dimer interface [polypeptide binding]; other site 1052588007410 motif 1; other site 1052588007411 active site 1052588007412 motif 2; other site 1052588007413 motif 3; other site 1052588007414 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1052588007415 anticodon binding site; other site 1052588007416 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 1052588007417 Bacterial SH3 domain; Region: SH3_3; cl02551 1052588007418 Bacterial SH3 domain; Region: SH3_3; cl02551 1052588007419 Bacterial SH3 domain; Region: SH3_3; cl02551 1052588007420 Bacterial SH3 domain; Region: SH3_3; cl02551 1052588007421 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1052588007422 active site 1052588007423 metal binding site [ion binding]; metal-binding site 1052588007424 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1052588007425 putative active site [active] 1052588007426 dimerization interface [polypeptide binding]; other site 1052588007427 putative tRNAtyr binding site [nucleotide binding]; other site 1052588007428 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1052588007429 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1052588007430 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1052588007431 synthetase active site [active] 1052588007432 NTP binding site [chemical binding]; other site 1052588007433 metal binding site [ion binding]; metal-binding site 1052588007434 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1052588007435 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1052588007436 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052588007437 active site 1052588007438 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1052588007439 DHH family; Region: DHH; pfam01368 1052588007440 DHHA1 domain; Region: DHHA1; pfam02272 1052588007441 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 1052588007442 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 1052588007443 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1052588007444 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1052588007445 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1052588007446 Protein export membrane protein; Region: SecD_SecF; cl14618 1052588007447 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1052588007448 Protein export membrane protein; Region: SecD_SecF; cl14618 1052588007449 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 1052588007450 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1052588007451 MatE; Region: MatE; cl10513 1052588007452 MatE; Region: MatE; cl10513 1052588007453 Protein of unknown function (DUF421); Region: DUF421; cl00990 1052588007454 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 1052588007455 Preprotein translocase subunit; Region: YajC; cl00806 1052588007456 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1052588007457 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 1052588007458 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1052588007459 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 1052588007460 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 1052588007461 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1052588007462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588007463 Walker A motif; other site 1052588007464 ATP binding site [chemical binding]; other site 1052588007465 Walker B motif; other site 1052588007466 arginine finger; other site 1052588007467 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1052588007468 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1052588007469 RuvA N terminal domain; Region: RuvA_N; pfam01330 1052588007470 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1052588007471 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 1052588007472 BofC C-terminal domain; Region: BofC_C; pfam08955 1052588007473 polyol permease family; Region: 2A0118; TIGR00897 1052588007474 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588007475 putative substrate translocation pore; other site 1052588007476 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052588007477 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588007478 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1052588007479 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 1052588007480 active site 1052588007481 substrate binding site [chemical binding]; other site 1052588007482 ATP binding site [chemical binding]; other site 1052588007483 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1052588007484 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1052588007485 Transcriptional regulator; Region: Transcrip_reg; cl00361 1052588007486 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1052588007487 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588007488 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1052588007489 Quinolinate synthetase A protein; Region: NadA; cl00420 1052588007490 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 1052588007491 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1052588007492 dimerization interface [polypeptide binding]; other site 1052588007493 active site 1052588007494 L-aspartate oxidase; Provisional; Region: PRK08071 1052588007495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588007496 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1052588007497 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1052588007498 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 1052588007499 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052588007500 catalytic residue [active] 1052588007501 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1052588007502 Helix-turn-helix domains; Region: HTH; cl00088 1052588007503 3H domain; Region: 3H; pfam02829 1052588007504 prephenate dehydratase; Provisional; Region: PRK11898 1052588007505 Prephenate dehydratase; Region: PDT; pfam00800 1052588007506 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1052588007507 putative L-Phe binding site [chemical binding]; other site 1052588007508 hypothetical protein; Provisional; Region: PRK04435 1052588007509 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 1052588007510 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1052588007511 GTP1/OBG; Region: GTP1_OBG; pfam01018 1052588007512 Obg GTPase; Region: Obg; cd01898 1052588007513 G1 box; other site 1052588007514 GTP/Mg2+ binding site [chemical binding]; other site 1052588007515 Switch I region; other site 1052588007516 G2 box; other site 1052588007517 G3 box; other site 1052588007518 Switch II region; other site 1052588007519 G4 box; other site 1052588007520 G5 box; other site 1052588007521 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 1052588007522 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1052588007523 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 1052588007524 Protein of unknown function (DUF464); Region: DUF464; cl01080 1052588007525 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 1052588007526 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 1052588007527 active site 1052588007528 putative substrate binding region [chemical binding]; other site 1052588007529 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1052588007530 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 1052588007531 septum site-determining protein MinD; Region: minD_bact; TIGR01968 1052588007532 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1052588007533 Switch I; other site 1052588007534 Switch II; other site 1052588007535 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1052588007536 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1052588007537 rod shape-determining protein MreD; Region: MreD; cl01087 1052588007538 rod shape-determining protein MreC; Region: mreC; TIGR00219 1052588007539 rod shape-determining protein MreC; Region: MreC; pfam04085 1052588007540 rod shape-determining protein MreB; Provisional; Region: PRK13927 1052588007541 Cell division protein FtsA; Region: FtsA; cl11496 1052588007542 hypothetical protein; Reviewed; Region: PRK00024 1052588007543 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1052588007544 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1052588007545 MPN+ (JAMM) motif; other site 1052588007546 Zinc-binding site [ion binding]; other site 1052588007547 Maf-like protein; Region: Maf; pfam02545 1052588007548 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1052588007549 active site 1052588007550 dimer interface [polypeptide binding]; other site 1052588007551 Sporulation related domain; Region: SPOR; cl10051 1052588007552 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1052588007553 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1052588007554 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 1052588007555 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 1052588007556 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1052588007557 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1052588007558 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1052588007559 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1052588007560 active site 1052588007561 HIGH motif; other site 1052588007562 nucleotide binding site [chemical binding]; other site 1052588007563 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1052588007564 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1052588007565 active site 1052588007566 KMSKS motif; other site 1052588007567 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1052588007568 tRNA binding surface [nucleotide binding]; other site 1052588007569 anticodon binding site; other site 1052588007570 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1052588007571 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052588007572 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 1052588007573 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 1052588007574 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052588007575 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1052588007576 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052588007577 inhibitor-cofactor binding pocket; inhibition site 1052588007578 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588007579 catalytic residue [active] 1052588007580 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1052588007581 dimer interface [polypeptide binding]; other site 1052588007582 active site 1052588007583 Schiff base residues; other site 1052588007584 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1052588007585 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1052588007586 active site 1052588007587 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1052588007588 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1052588007589 domain interfaces; other site 1052588007590 active site 1052588007591 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1052588007592 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1052588007593 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1052588007594 tRNA; other site 1052588007595 putative tRNA binding site [nucleotide binding]; other site 1052588007596 putative NADP binding site [chemical binding]; other site 1052588007597 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1052588007598 Predicted GTPase [General function prediction only]; Region: COG0218 1052588007599 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1052588007600 G1 box; other site 1052588007601 GTP/Mg2+ binding site [chemical binding]; other site 1052588007602 Switch I region; other site 1052588007603 G2 box; other site 1052588007604 G3 box; other site 1052588007605 Switch II region; other site 1052588007606 G4 box; other site 1052588007607 G5 box; other site 1052588007608 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1052588007609 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1052588007610 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1052588007611 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588007612 Walker A motif; other site 1052588007613 ATP binding site [chemical binding]; other site 1052588007614 Walker B motif; other site 1052588007615 arginine finger; other site 1052588007616 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1052588007617 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 1052588007618 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588007619 Walker A motif; other site 1052588007620 ATP binding site [chemical binding]; other site 1052588007621 Walker B motif; other site 1052588007622 arginine finger; other site 1052588007623 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1052588007624 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1052588007625 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 1052588007626 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588007627 Walker A motif; other site 1052588007628 ATP binding site [chemical binding]; other site 1052588007629 Walker B motif; other site 1052588007630 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1052588007631 trigger factor; Provisional; Region: tig; PRK01490 1052588007632 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 1052588007633 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1052588007634 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588007635 binding surface 1052588007636 TPR motif; other site 1052588007637 ApbE family; Region: ApbE; cl00643 1052588007638 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1052588007639 substrate binding site [chemical binding]; other site 1052588007640 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1052588007641 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1052588007642 substrate binding site [chemical binding]; other site 1052588007643 ligand binding site [chemical binding]; other site 1052588007644 tartrate dehydrogenase; Provisional; Region: PRK08194 1052588007645 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1052588007646 2-isopropylmalate synthase; Validated; Region: PRK00915 1052588007647 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1052588007648 active site 1052588007649 metal binding site [ion binding]; metal-binding site 1052588007650 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 1052588007651 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1052588007652 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588007653 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1052588007654 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1052588007655 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1052588007656 putative valine binding site [chemical binding]; other site 1052588007657 dimer interface [polypeptide binding]; other site 1052588007658 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1052588007659 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 1052588007660 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1052588007661 PYR/PP interface [polypeptide binding]; other site 1052588007662 dimer interface [polypeptide binding]; other site 1052588007663 TPP binding site [chemical binding]; other site 1052588007664 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1052588007665 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1052588007666 TPP-binding site [chemical binding]; other site 1052588007667 dimer interface [polypeptide binding]; other site 1052588007668 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1052588007669 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588007670 Coenzyme A binding pocket [chemical binding]; other site 1052588007671 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1052588007672 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1052588007673 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 1052588007674 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1052588007675 Heat induced stress protein YflT; Region: YflT; pfam11181 1052588007676 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 1052588007677 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1052588007678 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1052588007679 active site 1052588007680 metal binding site [ion binding]; metal-binding site 1052588007681 homotetramer interface [polypeptide binding]; other site 1052588007682 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1052588007683 active site 1052588007684 dimerization interface [polypeptide binding]; other site 1052588007685 ribonuclease PH; Reviewed; Region: rph; PRK00173 1052588007686 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1052588007687 hexamer interface [polypeptide binding]; other site 1052588007688 active site 1052588007689 Spore germination protein [General function prediction only]; Region: COG5401 1052588007690 Sporulation and spore germination; Region: Germane; cl11253 1052588007691 Sporulation and spore germination; Region: Germane; cl11253 1052588007692 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1052588007693 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588007694 Helix-turn-helix domains; Region: HTH; cl00088 1052588007695 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052588007696 DNA binding residues [nucleotide binding] 1052588007697 dimerization interface [polypeptide binding]; other site 1052588007698 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1052588007699 active site 1052588007700 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1052588007701 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1052588007702 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1052588007703 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1052588007704 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588007705 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1052588007706 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1052588007707 putative Iron-sulfur protein interface [polypeptide binding]; other site 1052588007708 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1052588007709 proximal heme binding site [chemical binding]; other site 1052588007710 distal heme binding site [chemical binding]; other site 1052588007711 putative dimer interface [polypeptide binding]; other site 1052588007712 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1052588007713 aspartate kinase; Reviewed; Region: PRK06635 1052588007714 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1052588007715 putative nucleotide binding site [chemical binding]; other site 1052588007716 putative catalytic residues [active] 1052588007717 putative Mg ion binding site [ion binding]; other site 1052588007718 putative aspartate binding site [chemical binding]; other site 1052588007719 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1052588007720 putative allosteric regulatory site; other site 1052588007721 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1052588007722 putative allosteric regulatory residue; other site 1052588007723 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1052588007724 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1052588007725 GIY-YIG motif/motif A; other site 1052588007726 active site 1052588007727 catalytic site [active] 1052588007728 putative DNA binding site [nucleotide binding]; other site 1052588007729 metal binding site [ion binding]; metal-binding site 1052588007730 UvrB/uvrC motif; Region: UVR; pfam02151 1052588007731 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1052588007732 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1052588007733 catalytic residues [active] 1052588007734 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1052588007735 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 1052588007736 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1052588007737 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1052588007738 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1052588007739 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1052588007740 Ligand binding site [chemical binding]; other site 1052588007741 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1052588007742 enoyl-CoA hydratase; Provisional; Region: PRK07658 1052588007743 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1052588007744 substrate binding site [chemical binding]; other site 1052588007745 oxyanion hole (OAH) forming residues; other site 1052588007746 trimer interface [polypeptide binding]; other site 1052588007747 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052588007748 Helix-turn-helix domains; Region: HTH; cl00088 1052588007749 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1052588007750 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 1052588007751 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588007752 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052588007753 Predicted membrane protein [Function unknown]; Region: COG3766 1052588007754 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1052588007755 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1052588007756 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1052588007757 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 1052588007758 Walker A/P-loop; other site 1052588007759 ATP binding site [chemical binding]; other site 1052588007760 Q-loop/lid; other site 1052588007761 ABC transporter signature motif; other site 1052588007762 Walker B; other site 1052588007763 D-loop; other site 1052588007764 H-loop/switch region; other site 1052588007765 Smr domain; Region: Smr; cl02619 1052588007766 hypothetical protein; Provisional; Region: PRK08609 1052588007767 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1052588007768 active site 1052588007769 primer binding site [nucleotide binding]; other site 1052588007770 NTP binding site [chemical binding]; other site 1052588007771 metal binding triad [ion binding]; metal-binding site 1052588007772 Colicin V production protein; Region: Colicin_V; cl00567 1052588007773 Cell division protein ZapA; Region: ZapA; cl01146 1052588007774 ribonuclease HIII; Provisional; Region: PRK00996 1052588007775 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1052588007776 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1052588007777 RNA/DNA hybrid binding site [nucleotide binding]; other site 1052588007778 active site 1052588007779 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1052588007780 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1052588007781 putative tRNA-binding site [nucleotide binding]; other site 1052588007782 B3/4 domain; Region: B3_4; cl11458 1052588007783 tRNA synthetase B5 domain; Region: B5; cl08394 1052588007784 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1052588007785 dimer interface [polypeptide binding]; other site 1052588007786 motif 1; other site 1052588007787 motif 3; other site 1052588007788 motif 2; other site 1052588007789 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 1052588007790 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1052588007791 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1052588007792 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1052588007793 dimer interface [polypeptide binding]; other site 1052588007794 motif 1; other site 1052588007795 active site 1052588007796 motif 2; other site 1052588007797 motif 3; other site 1052588007798 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1052588007799 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 1052588007800 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1052588007801 Small, acid-soluble spore protein I; Region: SSPI; cl07940 1052588007802 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1052588007803 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1052588007804 Helix-turn-helix domains; Region: HTH; cl00088 1052588007805 FAD binding domain; Region: FAD_binding_4; pfam01565 1052588007806 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1052588007807 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1052588007808 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1052588007809 Cysteine-rich domain; Region: CCG; pfam02754 1052588007810 Cysteine-rich domain; Region: CCG; pfam02754 1052588007811 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1052588007812 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052588007813 active site 1052588007814 metal binding site [ion binding]; metal-binding site 1052588007815 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1052588007816 Carbon starvation protein CstA; Region: CstA; pfam02554 1052588007817 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1052588007818 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1052588007819 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 1052588007820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588007821 dimer interface [polypeptide binding]; other site 1052588007822 conserved gate region; other site 1052588007823 putative PBP binding loops; other site 1052588007824 ABC-ATPase subunit interface; other site 1052588007825 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052588007826 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588007827 dimer interface [polypeptide binding]; other site 1052588007828 conserved gate region; other site 1052588007829 putative PBP binding loops; other site 1052588007830 ABC-ATPase subunit interface; other site 1052588007831 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052588007832 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1052588007833 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1052588007834 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1052588007835 active site 1052588007836 metal binding site [ion binding]; metal-binding site 1052588007837 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1052588007838 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588007839 active site 1052588007840 motif I; other site 1052588007841 motif II; other site 1052588007842 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588007843 motif II; other site 1052588007844 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1052588007845 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1052588007846 intersubunit interface [polypeptide binding]; other site 1052588007847 active site 1052588007848 Zn2+ binding site [ion binding]; other site 1052588007849 L-ribulokinase; Region: L-ribulokinase; TIGR01234 1052588007850 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1052588007851 putative N- and C-terminal domain interface [polypeptide binding]; other site 1052588007852 putative active site [active] 1052588007853 putative MgATP binding site [chemical binding]; other site 1052588007854 catalytic site [active] 1052588007855 metal binding site [ion binding]; metal-binding site 1052588007856 carbohydrate binding site [chemical binding]; other site 1052588007857 homodimer interface [polypeptide binding]; other site 1052588007858 L-arabinose isomerase; Provisional; Region: PRK02929 1052588007859 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1052588007860 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1052588007861 trimer interface [polypeptide binding]; other site 1052588007862 putative substrate binding site [chemical binding]; other site 1052588007863 putative metal binding site [ion binding]; other site 1052588007864 Glycosyl hydrolase family 43; Region: GH43_ABN; cd08988 1052588007865 substrate binding site [chemical binding]; other site 1052588007866 active site 1052588007867 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1052588007868 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1052588007869 oligomer interface [polypeptide binding]; other site 1052588007870 active site 1052588007871 metal binding site [ion binding]; metal-binding site 1052588007872 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 1052588007873 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1052588007874 23S rRNA binding site [nucleotide binding]; other site 1052588007875 L21 binding site [polypeptide binding]; other site 1052588007876 L13 binding site [polypeptide binding]; other site 1052588007877 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 1052588007878 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1052588007879 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1052588007880 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1052588007881 LrgB-like family; Region: LrgB; cl00596 1052588007882 LrgA family; Region: LrgA; cl00608 1052588007883 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1052588007884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588007885 active site 1052588007886 phosphorylation site [posttranslational modification] 1052588007887 intermolecular recognition site; other site 1052588007888 dimerization interface [polypeptide binding]; other site 1052588007889 LytTr DNA-binding domain; Region: LytTR; cl04498 1052588007890 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1052588007891 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 1052588007892 GAF domain; Region: GAF; cl15785 1052588007893 Histidine kinase; Region: His_kinase; pfam06580 1052588007894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588007895 ATP binding site [chemical binding]; other site 1052588007896 Mg2+ binding site [ion binding]; other site 1052588007897 G-X-G motif; other site 1052588007898 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1052588007899 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588007900 motif II; other site 1052588007901 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1052588007902 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1052588007903 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 1052588007904 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1052588007905 active site 1052588007906 dimer interface [polypeptide binding]; other site 1052588007907 motif 1; other site 1052588007908 motif 2; other site 1052588007909 motif 3; other site 1052588007910 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1052588007911 anticodon binding site; other site 1052588007912 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1052588007913 primosomal protein DnaI; Reviewed; Region: PRK08939 1052588007914 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1052588007915 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588007916 Walker A motif; other site 1052588007917 ATP binding site [chemical binding]; other site 1052588007918 Walker B motif; other site 1052588007919 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1052588007920 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 1052588007921 ATP cone domain; Region: ATP-cone; pfam03477 1052588007922 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 1052588007923 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1052588007924 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588007925 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1052588007926 Helix-turn-helix domains; Region: HTH; cl00088 1052588007927 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052588007928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588007929 putative substrate translocation pore; other site 1052588007930 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052588007931 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052588007932 active site 1052588007933 catalytic tetrad [active] 1052588007934 dephospho-CoA kinase; Region: TIGR00152 1052588007935 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1052588007936 CoA-binding site [chemical binding]; other site 1052588007937 ATP-binding [chemical binding]; other site 1052588007938 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1052588007939 Domain of unknown function DUF; Region: DUF204; pfam02659 1052588007940 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1052588007941 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1052588007942 DNA binding site [nucleotide binding] 1052588007943 catalytic residue [active] 1052588007944 H2TH interface [polypeptide binding]; other site 1052588007945 putative catalytic residues [active] 1052588007946 turnover-facilitating residue; other site 1052588007947 intercalation triad [nucleotide binding]; other site 1052588007948 8OG recognition residue [nucleotide binding]; other site 1052588007949 putative reading head residues; other site 1052588007950 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1052588007951 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1052588007952 DNA polymerase I; Provisional; Region: PRK05755 1052588007953 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1052588007954 active site 1052588007955 metal binding site 1 [ion binding]; metal-binding site 1052588007956 putative 5' ssDNA interaction site; other site 1052588007957 metal binding site 3; metal-binding site 1052588007958 metal binding site 2 [ion binding]; metal-binding site 1052588007959 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1052588007960 putative DNA binding site [nucleotide binding]; other site 1052588007961 putative metal binding site [ion binding]; other site 1052588007962 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1052588007963 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1052588007964 active site 1052588007965 DNA binding site [nucleotide binding] 1052588007966 catalytic site [active] 1052588007967 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1052588007968 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1052588007969 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052588007970 dimer interface [polypeptide binding]; other site 1052588007971 phosphorylation site [posttranslational modification] 1052588007972 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588007973 ATP binding site [chemical binding]; other site 1052588007974 Mg2+ binding site [ion binding]; other site 1052588007975 G-X-G motif; other site 1052588007976 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052588007977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588007978 active site 1052588007979 phosphorylation site [posttranslational modification] 1052588007980 intermolecular recognition site; other site 1052588007981 dimerization interface [polypeptide binding]; other site 1052588007982 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052588007983 DNA binding site [nucleotide binding] 1052588007984 malate dehydrogenase; Reviewed; Region: PRK06223 1052588007985 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1052588007986 NAD(P) binding site [chemical binding]; other site 1052588007987 dimer interface [polypeptide binding]; other site 1052588007988 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052588007989 substrate binding site [chemical binding]; other site 1052588007990 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1052588007991 isocitrate dehydrogenase; Validated; Region: PRK07362 1052588007992 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1052588007993 dimer interface [polypeptide binding]; other site 1052588007994 Citrate synthase; Region: Citrate_synt; pfam00285 1052588007995 active site 1052588007996 citrylCoA binding site [chemical binding]; other site 1052588007997 oxalacetate/citrate binding site [chemical binding]; other site 1052588007998 coenzyme A binding site [chemical binding]; other site 1052588007999 catalytic triad [active] 1052588008000 Protein of unknown function (DUF441); Region: DUF441; cl01041 1052588008001 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1052588008002 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1052588008003 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 1052588008004 pyruvate kinase; Provisional; Region: PRK06354 1052588008005 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1052588008006 domain interfaces; other site 1052588008007 active site 1052588008008 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1052588008009 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1052588008010 active site 1052588008011 ADP/pyrophosphate binding site [chemical binding]; other site 1052588008012 dimerization interface [polypeptide binding]; other site 1052588008013 allosteric effector site; other site 1052588008014 fructose-1,6-bisphosphate binding site; other site 1052588008015 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1052588008016 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1052588008017 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1052588008018 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1052588008019 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1052588008020 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1052588008021 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1052588008022 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1052588008023 putative NAD(P) binding site [chemical binding]; other site 1052588008024 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 1052588008025 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1052588008026 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 1052588008027 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1052588008028 generic binding surface I; other site 1052588008029 generic binding surface II; other site 1052588008030 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 1052588008031 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1052588008032 DHH family; Region: DHH; pfam01368 1052588008033 DHHA1 domain; Region: DHHA1; pfam02272 1052588008034 YtpI-like protein; Region: YtpI; pfam14007 1052588008035 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1052588008036 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588008037 DNA-binding site [nucleotide binding]; DNA binding site 1052588008038 DRTGG domain; Region: DRTGG; cl12147 1052588008039 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1052588008040 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1052588008041 active site 2 [active] 1052588008042 active site 1 [active] 1052588008043 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052588008044 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1052588008045 classical (c) SDRs; Region: SDR_c; cd05233 1052588008046 NAD(P) binding site [chemical binding]; other site 1052588008047 active site 1052588008048 argininosuccinate lyase; Provisional; Region: PRK00855 1052588008049 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1052588008050 active sites [active] 1052588008051 tetramer interface [polypeptide binding]; other site 1052588008052 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 1052588008053 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1052588008054 ANP binding site [chemical binding]; other site 1052588008055 Substrate Binding Site II [chemical binding]; other site 1052588008056 Substrate Binding Site I [chemical binding]; other site 1052588008057 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1052588008058 MPT binding site; other site 1052588008059 trimer interface [polypeptide binding]; other site 1052588008060 acetate kinase; Region: ackA; TIGR00016 1052588008061 Acetokinase family; Region: Acetate_kinase; cl01029 1052588008062 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1052588008063 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588008064 S-adenosylmethionine binding site [chemical binding]; other site 1052588008065 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1052588008066 dimer interface [polypeptide binding]; other site 1052588008067 catalytic triad [active] 1052588008068 peroxidatic and resolving cysteines [active] 1052588008069 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 1052588008070 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 1052588008071 RDD family; Region: RDD; cl00746 1052588008072 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1052588008073 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1052588008074 tandem repeat interface [polypeptide binding]; other site 1052588008075 oligomer interface [polypeptide binding]; other site 1052588008076 active site residues [active] 1052588008077 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1052588008078 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1052588008079 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1052588008080 active site 1052588008081 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1052588008082 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588008083 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052588008084 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052588008085 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1052588008086 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1052588008087 THUMP domain; Region: THUMP; cl12076 1052588008088 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1052588008089 Ligand Binding Site [chemical binding]; other site 1052588008090 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1052588008091 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 1052588008092 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052588008093 catalytic residue [active] 1052588008094 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1052588008095 septation ring formation regulator EzrA; Provisional; Region: PRK04778 1052588008096 histidinol-phosphatase; Reviewed; Region: PRK08123 1052588008097 PHP-associated; Region: PHP_C; pfam13263 1052588008098 Helix-turn-helix domains; Region: HTH; cl00088 1052588008099 GAF domain; Region: GAF; cl15785 1052588008100 GAF domain; Region: GAF; cl15785 1052588008101 GAF domain; Region: GAF; cl15785 1052588008102 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1052588008103 metal binding site [ion binding]; metal-binding site 1052588008104 active site 1052588008105 I-site; other site 1052588008106 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1052588008107 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1052588008108 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052588008109 RNA binding surface [nucleotide binding]; other site 1052588008110 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1052588008111 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 1052588008112 active site 1052588008113 HIGH motif; other site 1052588008114 dimer interface [polypeptide binding]; other site 1052588008115 KMSKS motif; other site 1052588008116 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052588008117 RNA binding surface [nucleotide binding]; other site 1052588008118 acetyl-CoA synthetase; Provisional; Region: PRK04319 1052588008119 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1052588008120 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588008121 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052588008122 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052588008123 FOG: CBS domain [General function prediction only]; Region: COG0517 1052588008124 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 1052588008125 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 1052588008126 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1052588008127 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 1052588008128 flagellar motor protein MotS; Reviewed; Region: PRK06925 1052588008129 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1052588008130 ligand binding site [chemical binding]; other site 1052588008131 flagellar motor protein MotP; Reviewed; Region: PRK06926 1052588008132 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1052588008133 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1052588008134 dimerization interface [polypeptide binding]; other site 1052588008135 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1052588008136 effector binding site; other site 1052588008137 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1052588008138 Chorismate mutase type II; Region: CM_2; cl00693 1052588008139 NeuB family; Region: NeuB; cl00496 1052588008140 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1052588008141 YtxH-like protein; Region: YtxH; cl02079 1052588008142 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 1052588008143 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1052588008144 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1052588008145 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1052588008146 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1052588008147 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1052588008148 putative tRNA-binding site [nucleotide binding]; other site 1052588008149 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 1052588008150 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1052588008151 catalytic residues [active] 1052588008152 Protein of unknown function (DUF2872); Region: DUF2872; cl11924 1052588008153 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1052588008154 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1052588008155 oligomer interface [polypeptide binding]; other site 1052588008156 active site 1052588008157 metal binding site [ion binding]; metal-binding site 1052588008158 Predicted small secreted protein [Function unknown]; Region: COG5584 1052588008159 malate dehydrogenase; Provisional; Region: PRK13529 1052588008160 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1052588008161 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1052588008162 NAD(P) binding site [chemical binding]; other site 1052588008163 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052588008164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588008165 S-adenosylmethionine binding site [chemical binding]; other site 1052588008166 YtzH-like protein; Region: YtzH; pfam14165 1052588008167 Phosphotransferase enzyme family; Region: APH; pfam01636 1052588008168 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 1052588008169 substrate binding site [chemical binding]; other site 1052588008170 pullulanase, type I; Region: pulA_typeI; TIGR02104 1052588008171 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1052588008172 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1052588008173 Ca binding site [ion binding]; other site 1052588008174 active site 1052588008175 catalytic site [active] 1052588008176 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1052588008177 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1052588008178 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1052588008179 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1052588008180 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1052588008181 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1052588008182 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1052588008183 dimer interface [polypeptide binding]; other site 1052588008184 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588008185 catalytic residue [active] 1052588008186 dipeptidase PepV; Reviewed; Region: PRK07318 1052588008187 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1052588008188 active site 1052588008189 metal binding site [ion binding]; metal-binding site 1052588008190 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1052588008191 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 1052588008192 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1052588008193 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1052588008194 Walker A/P-loop; other site 1052588008195 ATP binding site [chemical binding]; other site 1052588008196 Q-loop/lid; other site 1052588008197 ABC transporter signature motif; other site 1052588008198 Walker B; other site 1052588008199 D-loop; other site 1052588008200 H-loop/switch region; other site 1052588008201 Helix-turn-helix domains; Region: HTH; cl00088 1052588008202 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1052588008203 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052588008204 RNA binding surface [nucleotide binding]; other site 1052588008205 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1052588008206 active site 1052588008207 uracil binding [chemical binding]; other site 1052588008208 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1052588008209 MatE; Region: MatE; cl10513 1052588008210 MatE; Region: MatE; cl10513 1052588008211 HI0933-like protein; Region: HI0933_like; pfam03486 1052588008212 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588008213 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588008214 BCCT family transporter; Region: BCCT; cl00569 1052588008215 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 1052588008216 Protein of unknown function, DUF624; Region: DUF624; cl02369 1052588008217 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588008218 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1052588008219 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1052588008220 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052588008221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1052588008222 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1052588008223 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052588008224 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052588008225 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052588008226 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052588008227 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052588008228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588008229 dimer interface [polypeptide binding]; other site 1052588008230 conserved gate region; other site 1052588008231 putative PBP binding loops; other site 1052588008232 ABC-ATPase subunit interface; other site 1052588008233 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588008234 NAD(P) binding site [chemical binding]; other site 1052588008235 active site 1052588008236 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1052588008237 Cytochrome P450; Region: p450; pfam00067 1052588008238 biotin synthase; Validated; Region: PRK06256 1052588008239 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052588008240 FeS/SAM binding site; other site 1052588008241 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 1052588008242 AAA domain; Region: AAA_26; pfam13500 1052588008243 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588008244 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588008245 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1052588008246 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1052588008247 substrate-cofactor binding pocket; other site 1052588008248 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588008249 catalytic residue [active] 1052588008250 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 1052588008251 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052588008252 inhibitor-cofactor binding pocket; inhibition site 1052588008253 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588008254 catalytic residue [active] 1052588008255 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 1052588008256 6-carboxyhexanoate--CoA ligase; Region: BioW; cl00625 1052588008257 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1052588008258 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052588008259 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 1052588008260 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052588008261 DNA binding site [nucleotide binding] 1052588008262 domain linker motif; other site 1052588008263 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1052588008264 putative ligand binding site [chemical binding]; other site 1052588008265 putative dimerization interface [polypeptide binding]; other site 1052588008266 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1052588008267 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1052588008268 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052588008269 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588008270 dimer interface [polypeptide binding]; other site 1052588008271 conserved gate region; other site 1052588008272 putative PBP binding loops; other site 1052588008273 ABC-ATPase subunit interface; other site 1052588008274 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052588008275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588008276 dimer interface [polypeptide binding]; other site 1052588008277 conserved gate region; other site 1052588008278 putative PBP binding loops; other site 1052588008279 ABC-ATPase subunit interface; other site 1052588008280 alpha-galactosidase; Provisional; Region: PRK15076 1052588008281 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1052588008282 NAD binding site [chemical binding]; other site 1052588008283 sugar binding site [chemical binding]; other site 1052588008284 divalent metal binding site [ion binding]; other site 1052588008285 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052588008286 dimer interface [polypeptide binding]; other site 1052588008287 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1052588008288 active site residue [active] 1052588008289 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1052588008290 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1052588008291 HIGH motif; other site 1052588008292 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1052588008293 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1052588008294 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1052588008295 active site 1052588008296 KMSKS motif; other site 1052588008297 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1052588008298 tRNA binding surface [nucleotide binding]; other site 1052588008299 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 1052588008300 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052588008301 PAS domain; Region: PAS_9; pfam13426 1052588008302 putative active site [active] 1052588008303 heme pocket [chemical binding]; other site 1052588008304 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1052588008305 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588008306 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588008307 putative substrate translocation pore; other site 1052588008308 hypothetical protein; Provisional; Region: PRK11281 1052588008309 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1052588008310 FtsX-like permease family; Region: FtsX; cl15850 1052588008311 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052588008312 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1052588008313 Walker A/P-loop; other site 1052588008314 ATP binding site [chemical binding]; other site 1052588008315 Q-loop/lid; other site 1052588008316 ABC transporter signature motif; other site 1052588008317 Walker B; other site 1052588008318 D-loop; other site 1052588008319 H-loop/switch region; other site 1052588008320 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052588008321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588008322 ATP binding site [chemical binding]; other site 1052588008323 Mg2+ binding site [ion binding]; other site 1052588008324 G-X-G motif; other site 1052588008325 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052588008326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588008327 active site 1052588008328 phosphorylation site [posttranslational modification] 1052588008329 intermolecular recognition site; other site 1052588008330 dimerization interface [polypeptide binding]; other site 1052588008331 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052588008332 DNA binding site [nucleotide binding] 1052588008333 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1052588008334 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1052588008335 FtsX-like permease family; Region: FtsX; cl15850 1052588008336 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052588008337 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1052588008338 Walker A/P-loop; other site 1052588008339 ATP binding site [chemical binding]; other site 1052588008340 Q-loop/lid; other site 1052588008341 ABC transporter signature motif; other site 1052588008342 Walker B; other site 1052588008343 D-loop; other site 1052588008344 H-loop/switch region; other site 1052588008345 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1052588008346 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1052588008347 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052588008348 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1052588008349 Walker A/P-loop; other site 1052588008350 ATP binding site [chemical binding]; other site 1052588008351 Q-loop/lid; other site 1052588008352 ABC transporter signature motif; other site 1052588008353 Walker B; other site 1052588008354 D-loop; other site 1052588008355 H-loop/switch region; other site 1052588008356 Predicted transcriptional regulators [Transcription]; Region: COG1725 1052588008357 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588008358 DNA-binding site [nucleotide binding]; DNA binding site 1052588008359 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 1052588008360 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1052588008361 hypothetical protein; Provisional; Region: PRK08317 1052588008362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1052588008363 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 1052588008364 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1052588008365 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052588008366 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052588008367 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1052588008368 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1052588008369 trimer interface [polypeptide binding]; other site 1052588008370 putative metal binding site [ion binding]; other site 1052588008371 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1052588008372 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1052588008373 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1052588008374 active site 1052588008375 dimer interface [polypeptide binding]; other site 1052588008376 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1052588008377 Ligand Binding Site [chemical binding]; other site 1052588008378 Molecular Tunnel; other site 1052588008379 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1052588008380 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1052588008381 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1052588008382 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1052588008383 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1052588008384 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1052588008385 active site 1052588008386 substrate-binding site [chemical binding]; other site 1052588008387 metal-binding site [ion binding] 1052588008388 ATP binding site [chemical binding]; other site 1052588008389 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 1052588008390 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052588008391 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1052588008392 NMT1-like family; Region: NMT1_2; cl15260 1052588008393 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1052588008394 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 1052588008395 Walker A/P-loop; other site 1052588008396 ATP binding site [chemical binding]; other site 1052588008397 Q-loop/lid; other site 1052588008398 ABC transporter signature motif; other site 1052588008399 Walker B; other site 1052588008400 D-loop; other site 1052588008401 H-loop/switch region; other site 1052588008402 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1052588008403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588008404 dimer interface [polypeptide binding]; other site 1052588008405 conserved gate region; other site 1052588008406 putative PBP binding loops; other site 1052588008407 ABC-ATPase subunit interface; other site 1052588008408 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1052588008409 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1052588008410 nudix motif; other site 1052588008411 Holin family; Region: Phage_holin_4; cl01989 1052588008412 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1052588008413 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1052588008414 dimerization interface [polypeptide binding]; other site 1052588008415 DPS ferroxidase diiron center [ion binding]; other site 1052588008416 ion pore; other site 1052588008417 FixH; Region: FixH; cl01254 1052588008418 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 1052588008419 Haemolytic domain; Region: Haemolytic; cl00506 1052588008420 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1052588008421 active site clefts [active] 1052588008422 zinc binding site [ion binding]; other site 1052588008423 dimer interface [polypeptide binding]; other site 1052588008424 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 1052588008425 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1052588008426 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1052588008427 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1052588008428 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052588008429 ABC-ATPase subunit interface; other site 1052588008430 dimer interface [polypeptide binding]; other site 1052588008431 putative PBP binding regions; other site 1052588008432 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052588008433 ABC-ATPase subunit interface; other site 1052588008434 dimer interface [polypeptide binding]; other site 1052588008435 putative PBP binding regions; other site 1052588008436 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1052588008437 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1052588008438 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 1052588008439 Metal binding protein TroA. These proteins have been shown to function as initial receptors in ABC transport of Zn2+ and possibly Fe3+ in many eubacterial species. The TroA proteins belong to the TroA superfamily of periplasmic metal binding proteins...; Region: TroA; cd01016 1052588008440 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1052588008441 metal binding site [ion binding]; metal-binding site 1052588008442 intersubunit interface [polypeptide binding]; other site 1052588008443 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1052588008444 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1052588008445 active site 1052588008446 octamer interface [polypeptide binding]; other site 1052588008447 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 1052588008448 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588008449 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588008450 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1052588008451 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1052588008452 substrate binding site [chemical binding]; other site 1052588008453 oxyanion hole (OAH) forming residues; other site 1052588008454 trimer interface [polypeptide binding]; other site 1052588008455 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052588008456 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1052588008457 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1052588008458 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1052588008459 dimer interface [polypeptide binding]; other site 1052588008460 tetramer interface [polypeptide binding]; other site 1052588008461 PYR/PP interface [polypeptide binding]; other site 1052588008462 TPP binding site [chemical binding]; other site 1052588008463 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1052588008464 TPP-binding site; other site 1052588008465 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1052588008466 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1052588008467 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1052588008468 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1052588008469 active site 1052588008470 tetramer interface; other site 1052588008471 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 1052588008472 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588008473 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1052588008474 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588008475 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1052588008476 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588008477 NAD(P) binding site [chemical binding]; other site 1052588008478 active site 1052588008479 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1052588008480 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052588008481 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1052588008482 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052588008483 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052588008484 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1052588008485 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1052588008486 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052588008487 active site 1052588008488 ATP binding site [chemical binding]; other site 1052588008489 substrate binding site [chemical binding]; other site 1052588008490 TspO/MBR family; Region: TspO_MBR; cl01379 1052588008491 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1052588008492 homodimer interface [polypeptide binding]; other site 1052588008493 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1052588008494 active site pocket [active] 1052588008495 glycogen synthase; Provisional; Region: glgA; PRK00654 1052588008496 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1052588008497 ADP-binding pocket [chemical binding]; other site 1052588008498 homodimer interface [polypeptide binding]; other site 1052588008499 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 1052588008500 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1052588008501 ligand binding site; other site 1052588008502 oligomer interface; other site 1052588008503 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1052588008504 dimer interface [polypeptide binding]; other site 1052588008505 N-terminal domain interface [polypeptide binding]; other site 1052588008506 sulfate 1 binding site; other site 1052588008507 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 1052588008508 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1052588008509 ligand binding site; other site 1052588008510 oligomer interface; other site 1052588008511 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1052588008512 dimer interface [polypeptide binding]; other site 1052588008513 N-terminal domain interface [polypeptide binding]; other site 1052588008514 sulfate 1 binding site; other site 1052588008515 alpha-1,4-glucan:alpha-1,4-glucan 6-glycosyltransferase; Region: branching_enzym; TIGR01515 1052588008516 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1052588008517 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1052588008518 active site 1052588008519 catalytic site [active] 1052588008520 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 1052588008521 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 1052588008522 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1052588008523 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588008524 Coenzyme A binding pocket [chemical binding]; other site 1052588008525 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1052588008526 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1052588008527 DinB superfamily; Region: DinB_2; pfam12867 1052588008528 MOSC domain; Region: MOSC; pfam03473 1052588008529 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1052588008530 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1052588008531 active site 1052588008532 NAD binding site [chemical binding]; other site 1052588008533 metal binding site [ion binding]; metal-binding site 1052588008534 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 1052588008535 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1052588008536 tetramerization interface [polypeptide binding]; other site 1052588008537 NAD(P) binding site [chemical binding]; other site 1052588008538 catalytic residues [active] 1052588008539 Predicted transcriptional regulators [Transcription]; Region: COG1510 1052588008540 Helix-turn-helix domains; Region: HTH; cl00088 1052588008541 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1052588008542 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588008543 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1052588008544 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1052588008545 Cation transport protein; Region: TrkH; cl10514 1052588008546 yiaA/B two helix domain; Region: YiaAB; cl01759 1052588008547 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1052588008548 SH3-like domain; Region: SH3_8; pfam13457 1052588008549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588008550 putative substrate translocation pore; other site 1052588008551 Cysteine dioxygenase type I; Region: CDO_I; cl15835 1052588008552 Bacitracin resistance protein BacA; Region: BacA; cl00858 1052588008553 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1052588008554 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1052588008555 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052588008556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588008557 L-rhamnose isomerase; Provisional; Region: PRK01076 1052588008558 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 1052588008559 L-rhamnulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1052588008560 N- and C-terminal domain interface [polypeptide binding]; other site 1052588008561 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 1052588008562 active site 1052588008563 catalytic site [active] 1052588008564 metal binding site [ion binding]; metal-binding site 1052588008565 ATP binding site [chemical binding]; other site 1052588008566 carbohydrate binding site [chemical binding]; other site 1052588008567 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1052588008568 Helix-turn-helix domains; Region: HTH; cl00088 1052588008569 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1052588008570 short chain dehydrogenase; Validated; Region: PRK08324 1052588008571 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1052588008572 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 1052588008573 putative NAD(P) binding site [chemical binding]; other site 1052588008574 active site 1052588008575 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1052588008576 Cache domain; Region: Cache_1; pfam02743 1052588008577 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052588008578 dimerization interface [polypeptide binding]; other site 1052588008579 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052588008580 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052588008581 dimer interface [polypeptide binding]; other site 1052588008582 putative CheW interface [polypeptide binding]; other site 1052588008583 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052588008584 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1052588008585 Cache domain; Region: Cache_1; pfam02743 1052588008586 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052588008587 dimerization interface [polypeptide binding]; other site 1052588008588 proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785 1052588008589 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052588008590 dimer interface [polypeptide binding]; other site 1052588008591 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1052588008592 putative CheW interface [polypeptide binding]; other site 1052588008593 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1052588008594 Cache domain; Region: Cache_1; pfam02743 1052588008595 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 1052588008596 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052588008597 dimerization interface [polypeptide binding]; other site 1052588008598 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052588008599 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052588008600 dimer interface [polypeptide binding]; other site 1052588008601 putative CheW interface [polypeptide binding]; other site 1052588008602 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1052588008603 Cache domain; Region: Cache_1; pfam02743 1052588008604 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052588008605 dimerization interface [polypeptide binding]; other site 1052588008606 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052588008607 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052588008608 dimer interface [polypeptide binding]; other site 1052588008609 putative CheW interface [polypeptide binding]; other site 1052588008610 transglutaminase; Provisional; Region: tgl; PRK03187 1052588008611 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 1052588008612 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1052588008613 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1052588008614 Ca binding site [ion binding]; other site 1052588008615 active site 1052588008616 catalytic site [active] 1052588008617 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1052588008618 Domain of unknown function DUF21; Region: DUF21; pfam01595 1052588008619 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1052588008620 Transporter associated domain; Region: CorC_HlyC; cl08393 1052588008621 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 1052588008622 Membrane-integrating protein Mistic; Region: Mistic; pfam11458 1052588008623 Ion channel; Region: Ion_trans_2; cl11596 1052588008624 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588008625 YugN-like family; Region: YugN; pfam08868 1052588008626 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1052588008627 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1052588008628 active site 1052588008629 dimer interface [polypeptide binding]; other site 1052588008630 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1052588008631 dimer interface [polypeptide binding]; other site 1052588008632 active site 1052588008633 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1052588008634 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1052588008635 dimer interface [polypeptide binding]; other site 1052588008636 active site 1052588008637 metal binding site [ion binding]; metal-binding site 1052588008638 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1052588008639 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1052588008640 dimer interface [polypeptide binding]; other site 1052588008641 active site 1052588008642 metal binding site [ion binding]; metal-binding site 1052588008643 Domain of unknown function (DUF378); Region: DUF378; cl00943 1052588008644 general stress protein 13; Validated; Region: PRK08059 1052588008645 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 1052588008646 RNA binding site [nucleotide binding]; other site 1052588008647 hypothetical protein; Validated; Region: PRK07682 1052588008648 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052588008649 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588008650 homodimer interface [polypeptide binding]; other site 1052588008651 catalytic residue [active] 1052588008652 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1052588008653 Helix-turn-helix domains; Region: HTH; cl00088 1052588008654 AsnC family; Region: AsnC_trans_reg; pfam01037 1052588008655 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052588008656 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052588008657 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 1052588008658 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1052588008659 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052588008660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588008661 homodimer interface [polypeptide binding]; other site 1052588008662 catalytic residue [active] 1052588008663 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052588008664 dimer interface [polypeptide binding]; other site 1052588008665 phosphorylation site [posttranslational modification] 1052588008666 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588008667 ATP binding site [chemical binding]; other site 1052588008668 Mg2+ binding site [ion binding]; other site 1052588008669 G-X-G motif; other site 1052588008670 Kinase associated protein B; Region: KapB; pfam08810 1052588008671 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1052588008672 active site 1052588008673 catalytic site [active] 1052588008674 substrate binding site [chemical binding]; other site 1052588008675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588008676 drug efflux system protein MdtG; Provisional; Region: PRK09874 1052588008677 putative substrate translocation pore; other site 1052588008678 Transglycosylase; Region: Transgly; cl07896 1052588008679 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1052588008680 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052588008681 Protein of unknown function, DUF393; Region: DUF393; cl01136 1052588008682 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1052588008683 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1052588008684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588008685 ATP binding site [chemical binding]; other site 1052588008686 G-X-G motif; other site 1052588008687 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1052588008688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588008689 active site 1052588008690 phosphorylation site [posttranslational modification] 1052588008691 intermolecular recognition site; other site 1052588008692 dimerization interface [polypeptide binding]; other site 1052588008693 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1052588008694 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1052588008695 ligand binding site [chemical binding]; other site 1052588008696 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1052588008697 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 1052588008698 Walker A/P-loop; other site 1052588008699 ATP binding site [chemical binding]; other site 1052588008700 Q-loop/lid; other site 1052588008701 ABC transporter signature motif; other site 1052588008702 Walker B; other site 1052588008703 D-loop; other site 1052588008704 H-loop/switch region; other site 1052588008705 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 1052588008706 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1052588008707 TM-ABC transporter signature motif; other site 1052588008708 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1052588008709 TM-ABC transporter signature motif; other site 1052588008710 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 1052588008711 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 1052588008712 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 1052588008713 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1052588008714 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1052588008715 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1052588008716 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 1052588008717 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 1052588008718 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 1052588008719 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 1052588008720 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 1052588008721 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1052588008722 CoenzymeA binding site [chemical binding]; other site 1052588008723 subunit interaction site [polypeptide binding]; other site 1052588008724 PHB binding site; other site 1052588008725 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052588008726 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588008727 active site 1052588008728 phosphorylation site [posttranslational modification] 1052588008729 intermolecular recognition site; other site 1052588008730 dimerization interface [polypeptide binding]; other site 1052588008731 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052588008732 DNA binding residues [nucleotide binding] 1052588008733 dimerization interface [polypeptide binding]; other site 1052588008734 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1052588008735 Histidine kinase; Region: HisKA_3; pfam07730 1052588008736 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588008737 ATP binding site [chemical binding]; other site 1052588008738 Mg2+ binding site [ion binding]; other site 1052588008739 G-X-G motif; other site 1052588008740 Bacillus competence pheromone ComX; Region: ComX; pfam05952 1052588008741 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1052588008742 substrate binding pocket [chemical binding]; other site 1052588008743 substrate-Mg2+ binding site; other site 1052588008744 aspartate-rich region 1; other site 1052588008745 aspartate-rich region 2; other site 1052588008746 DegQ (SacQ) family; Region: DegQ; pfam08181 1052588008747 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1052588008748 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1052588008749 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1052588008750 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1052588008751 active site 1052588008752 Isochorismatase family; Region: Isochorismatase; pfam00857 1052588008753 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1052588008754 catalytic triad [active] 1052588008755 conserved cis-peptide bond; other site 1052588008756 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 1052588008757 YueH-like protein; Region: YueH; pfam14166 1052588008758 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1052588008759 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1052588008760 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1052588008761 Protein of unknown function (DUF2283); Region: DUF2283; cl02251 1052588008762 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1052588008763 short chain dehydrogenase; Provisional; Region: PRK06924 1052588008764 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 1052588008765 NADP binding site [chemical binding]; other site 1052588008766 homodimer interface [polypeptide binding]; other site 1052588008767 active site 1052588008768 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 1052588008769 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 1052588008770 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1052588008771 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1052588008772 Predicted membrane protein [Function unknown]; Region: COG1511 1052588008773 exosortase F-associated protein; Region: flavo_near_exo; TIGR04127 1052588008774 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1052588008775 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588008776 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588008777 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588008778 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 1052588008779 Ubiquitin-like proteins; Region: UBQ; cl00155 1052588008780 Ubiquitin homologues; Region: UBQ; smart00213 1052588008781 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1052588008782 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1052588008783 CodY GAF-like domain; Region: CodY; pfam06018 1052588008784 Helix-turn-helix domains; Region: HTH; cl00088 1052588008785 alanine dehydrogenase; Region: alaDH; TIGR00518 1052588008786 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 1052588008787 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588008788 Uncharacterized conserved protein [Function unknown]; Region: COG5634 1052588008789 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 1052588008790 MbtH-like protein; Region: MbtH; cl01279 1052588008791 peptide synthase; Provisional; Region: PRK12316 1052588008792 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588008793 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588008794 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588008795 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1052588008796 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052588008797 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588008798 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588008799 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588008800 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1052588008801 hydrophobic substrate binding pocket; other site 1052588008802 Isochorismatase family; Region: Isochorismatase; pfam00857 1052588008803 active site 1052588008804 conserved cis-peptide bond; other site 1052588008805 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588008806 2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275 1052588008807 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588008808 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588008809 isochorismate synthase DhbC; Validated; Region: PRK06923 1052588008810 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1052588008811 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1052588008812 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 1052588008813 putative NAD(P) binding site [chemical binding]; other site 1052588008814 active site 1052588008815 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052588008816 Putative esterase; Region: Esterase; pfam00756 1052588008817 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1052588008818 Moco binding site; other site 1052588008819 metal coordination site [ion binding]; other site 1052588008820 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 1052588008821 Predicted permease [General function prediction only]; Region: COG2056 1052588008822 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 1052588008823 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1052588008824 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1052588008825 interface (dimer of trimers) [polypeptide binding]; other site 1052588008826 Substrate-binding/catalytic site; other site 1052588008827 Zn-binding sites [ion binding]; other site 1052588008828 Divergent PAP2 family; Region: DUF212; cl00855 1052588008829 3D domain; Region: 3D; cl01439 1052588008830 Putative membrane protein; Region: YuiB; pfam14068 1052588008831 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107 1052588008832 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1052588008833 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052588008834 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1052588008835 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052588008836 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1052588008837 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 1052588008838 active site 1052588008839 Integral membrane protein DUF95; Region: DUF95; cl00572 1052588008840 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052588008841 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1052588008842 Walker A/P-loop; other site 1052588008843 ATP binding site [chemical binding]; other site 1052588008844 Q-loop/lid; other site 1052588008845 ABC transporter signature motif; other site 1052588008846 Walker B; other site 1052588008847 D-loop; other site 1052588008848 H-loop/switch region; other site 1052588008849 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1052588008850 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1052588008851 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588008852 Coenzyme A binding pocket [chemical binding]; other site 1052588008853 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1052588008854 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1052588008855 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1052588008856 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1052588008857 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1052588008858 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1052588008859 Nucleoside recognition; Region: Gate; cl00486 1052588008860 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1052588008861 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1052588008862 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1052588008863 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052588008864 Protein of unknown function (DUF1462); Region: DUF1462; cl11552 1052588008865 NifU-like domain; Region: NifU; cl00484 1052588008866 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1052588008867 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1052588008868 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1052588008869 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052588008870 homoserine kinase; Region: thrB; TIGR00191 1052588008871 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1052588008872 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1052588008873 threonine synthase; Reviewed; Region: PRK06721 1052588008874 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1052588008875 homodimer interface [polypeptide binding]; other site 1052588008876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588008877 catalytic residue [active] 1052588008878 homoserine dehydrogenase; Provisional; Region: PRK06349 1052588008879 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588008880 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1052588008881 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1052588008882 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052588008883 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1052588008884 tetramer interfaces [polypeptide binding]; other site 1052588008885 binuclear metal-binding site [ion binding]; other site 1052588008886 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1052588008887 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588008888 active site 1052588008889 motif I; other site 1052588008890 motif II; other site 1052588008891 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588008892 Protein of unknown function DUF86; Region: DUF86; cl01031 1052588008893 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 1052588008894 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1052588008895 lipoyl synthase; Provisional; Region: PRK05481 1052588008896 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052588008897 FeS/SAM binding site; other site 1052588008898 Peptidase family M23; Region: Peptidase_M23; pfam01551 1052588008899 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 1052588008900 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 1052588008901 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1052588008902 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1052588008903 active site 1052588008904 metal binding site [ion binding]; metal-binding site 1052588008905 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1052588008906 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 1052588008907 Protein of unknown function DUF72; Region: DUF72; cl00777 1052588008908 allantoinase; Provisional; Region: PRK06189 1052588008909 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1052588008910 active site 1052588008911 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1052588008912 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1052588008913 Helix-turn-helix domains; Region: HTH; cl00088 1052588008914 xanthine permease; Region: pbuX; TIGR03173 1052588008915 xanthine permease; Region: pbuX; TIGR03173 1052588008916 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 1052588008917 Uricase (urate oxidase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3648 1052588008918 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1052588008919 active site 1052588008920 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1052588008921 active site 1052588008922 homotetramer interface [polypeptide binding]; other site 1052588008923 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 1052588008924 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1052588008925 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1052588008926 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 1052588008927 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 1052588008928 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1052588008929 xanthine dehydrogenase C subunit; Region: pucC; TIGR03199 1052588008930 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1052588008931 Ligand binding site; other site 1052588008932 metal-binding site 1052588008933 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1052588008934 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1052588008935 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1052588008936 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1052588008937 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1052588008938 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052588008939 catalytic residue [active] 1052588008940 allantoate amidohydrolase; Reviewed; Region: PRK09290 1052588008941 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1052588008942 active site 1052588008943 metal binding site [ion binding]; metal-binding site 1052588008944 dimer interface [polypeptide binding]; other site 1052588008945 Endonuclease I; Region: Endonuclease_1; cl01003 1052588008946 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1052588008947 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 1052588008948 Walker A/P-loop; other site 1052588008949 ATP binding site [chemical binding]; other site 1052588008950 Q-loop/lid; other site 1052588008951 ABC transporter signature motif; other site 1052588008952 Walker B; other site 1052588008953 D-loop; other site 1052588008954 H-loop/switch region; other site 1052588008955 TOBE domain; Region: TOBE_2; cl01440 1052588008956 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 1052588008957 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588008958 DNA-binding site [nucleotide binding]; DNA binding site 1052588008959 UTRA domain; Region: UTRA; cl01230 1052588008960 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1052588008961 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 1052588008962 substrate binding site [chemical binding]; other site 1052588008963 ATP binding site [chemical binding]; other site 1052588008964 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052588008965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588008966 dimer interface [polypeptide binding]; other site 1052588008967 conserved gate region; other site 1052588008968 putative PBP binding loops; other site 1052588008969 ABC-ATPase subunit interface; other site 1052588008970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588008971 dimer interface [polypeptide binding]; other site 1052588008972 conserved gate region; other site 1052588008973 putative PBP binding loops; other site 1052588008974 ABC-ATPase subunit interface; other site 1052588008975 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052588008976 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1052588008977 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1052588008978 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1052588008979 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1052588008980 putative active site [active] 1052588008981 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1052588008982 dimer interface [polypeptide binding]; other site 1052588008983 active site 1052588008984 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1052588008985 GIY-YIG motif/motif A; other site 1052588008986 active site 1052588008987 catalytic site [active] 1052588008988 putative DNA binding site [nucleotide binding]; other site 1052588008989 metal binding site [ion binding]; metal-binding site 1052588008990 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1052588008991 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588008992 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052588008993 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1052588008994 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 1052588008995 FeS assembly protein SufB; Region: sufB; TIGR01980 1052588008996 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1052588008997 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1052588008998 trimerization site [polypeptide binding]; other site 1052588008999 active site 1052588009000 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1052588009001 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1052588009002 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052588009003 catalytic residue [active] 1052588009004 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1052588009005 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 1052588009006 FeS assembly ATPase SufC; Region: sufC; TIGR01978 1052588009007 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 1052588009008 Walker A/P-loop; other site 1052588009009 ATP binding site [chemical binding]; other site 1052588009010 Q-loop/lid; other site 1052588009011 ABC transporter signature motif; other site 1052588009012 Walker B; other site 1052588009013 D-loop; other site 1052588009014 H-loop/switch region; other site 1052588009015 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1052588009016 NMT1-like family; Region: NMT1_2; cl15260 1052588009017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588009018 conserved gate region; other site 1052588009019 ABC-ATPase subunit interface; other site 1052588009020 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1052588009021 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 1052588009022 Walker A/P-loop; other site 1052588009023 ATP binding site [chemical binding]; other site 1052588009024 Q-loop/lid; other site 1052588009025 ABC transporter signature motif; other site 1052588009026 Walker B; other site 1052588009027 D-loop; other site 1052588009028 H-loop/switch region; other site 1052588009029 NIL domain; Region: NIL; cl09633 1052588009030 SCP-2 sterol transfer family; Region: SCP2; cl01225 1052588009031 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1052588009032 catalytic residues [active] 1052588009033 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1052588009034 putative active site [active] 1052588009035 putative metal binding site [ion binding]; other site 1052588009036 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 1052588009037 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1052588009038 lipoyl attachment site [posttranslational modification]; other site 1052588009039 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1052588009040 ArsC family; Region: ArsC; pfam03960 1052588009041 putative ArsC-like catalytic residues; other site 1052588009042 putative TRX-like catalytic residues [active] 1052588009043 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1052588009044 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1052588009045 active site 1052588009046 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 1052588009047 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1052588009048 dimer interface [polypeptide binding]; other site 1052588009049 active site 1052588009050 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1052588009051 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588009052 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1052588009053 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1052588009054 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1052588009055 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1052588009056 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1052588009057 substrate binding site [chemical binding]; other site 1052588009058 oxyanion hole (OAH) forming residues; other site 1052588009059 trimer interface [polypeptide binding]; other site 1052588009060 Proline dehydrogenase; Region: Pro_dh; cl03282 1052588009061 Coat F domain; Region: Coat_F; cl15836 1052588009062 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588009063 Helix-turn-helix domains; Region: HTH; cl00088 1052588009064 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1052588009065 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588009066 putative substrate translocation pore; other site 1052588009067 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1052588009068 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1052588009069 classical (c) SDRs; Region: SDR_c; cd05233 1052588009070 NAD(P) binding site [chemical binding]; other site 1052588009071 active site 1052588009072 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052588009073 Helix-turn-helix domains; Region: HTH; cl00088 1052588009074 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1052588009075 dimerization interface [polypeptide binding]; other site 1052588009076 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 1052588009077 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1052588009078 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1052588009079 Walker A/P-loop; other site 1052588009080 ATP binding site [chemical binding]; other site 1052588009081 Q-loop/lid; other site 1052588009082 ABC transporter signature motif; other site 1052588009083 Walker B; other site 1052588009084 D-loop; other site 1052588009085 H-loop/switch region; other site 1052588009086 YusW-like protein; Region: YusW; pfam14039 1052588009087 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1052588009088 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 1052588009089 active site 1052588009090 Zn binding site [ion binding]; other site 1052588009091 short chain dehydrogenase; Provisional; Region: PRK06914 1052588009092 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1052588009093 NADP binding site [chemical binding]; other site 1052588009094 active site 1052588009095 steroid binding site; other site 1052588009096 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1052588009097 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1052588009098 dimerization interface [polypeptide binding]; other site 1052588009099 DPS ferroxidase diiron center [ion binding]; other site 1052588009100 ion pore; other site 1052588009101 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1052588009102 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1052588009103 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1052588009104 protein binding site [polypeptide binding]; other site 1052588009105 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052588009106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588009107 active site 1052588009108 phosphorylation site [posttranslational modification] 1052588009109 intermolecular recognition site; other site 1052588009110 dimerization interface [polypeptide binding]; other site 1052588009111 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052588009112 DNA binding site [nucleotide binding] 1052588009113 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052588009114 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052588009115 dimerization interface [polypeptide binding]; other site 1052588009116 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052588009117 dimer interface [polypeptide binding]; other site 1052588009118 phosphorylation site [posttranslational modification] 1052588009119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588009120 ATP binding site [chemical binding]; other site 1052588009121 Mg2+ binding site [ion binding]; other site 1052588009122 G-X-G motif; other site 1052588009123 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052588009124 Helix-turn-helix domains; Region: HTH; cl00088 1052588009125 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1052588009126 Class II fumarases; Region: Fumarase_classII; cd01362 1052588009127 active site 1052588009128 tetramer interface [polypeptide binding]; other site 1052588009129 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 1052588009130 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1052588009131 Spore germination protein; Region: Spore_permease; cl15802 1052588009132 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 1052588009133 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052588009134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588009135 active site 1052588009136 phosphorylation site [posttranslational modification] 1052588009137 intermolecular recognition site; other site 1052588009138 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052588009139 DNA binding residues [nucleotide binding] 1052588009140 dimerization interface [polypeptide binding]; other site 1052588009141 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052588009142 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1052588009143 Histidine kinase; Region: HisKA_3; pfam07730 1052588009144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588009145 ATP binding site [chemical binding]; other site 1052588009146 Mg2+ binding site [ion binding]; other site 1052588009147 G-X-G motif; other site 1052588009148 Predicted membrane protein [Function unknown]; Region: COG4758 1052588009149 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 1052588009150 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1052588009151 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1052588009152 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1052588009153 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1052588009154 PspA/IM30 family; Region: PspA_IM30; pfam04012 1052588009155 H+ Antiporter protein; Region: 2A0121; TIGR00900 1052588009156 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 1052588009157 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1052588009158 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1052588009159 Walker A/P-loop; other site 1052588009160 ATP binding site [chemical binding]; other site 1052588009161 Q-loop/lid; other site 1052588009162 ABC transporter signature motif; other site 1052588009163 Walker B; other site 1052588009164 D-loop; other site 1052588009165 H-loop/switch region; other site 1052588009166 Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808 1052588009167 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052588009168 ABC-ATPase subunit interface; other site 1052588009169 dimer interface [polypeptide binding]; other site 1052588009170 putative PBP binding regions; other site 1052588009171 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1052588009172 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1052588009173 putative binding site residues; other site 1052588009174 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1052588009175 classical (c) SDRs; Region: SDR_c; cd05233 1052588009176 NAD(P) binding site [chemical binding]; other site 1052588009177 active site 1052588009178 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1052588009179 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052588009180 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052588009181 dimer interface [polypeptide binding]; other site 1052588009182 phosphorylation site [posttranslational modification] 1052588009183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588009184 ATP binding site [chemical binding]; other site 1052588009185 Mg2+ binding site [ion binding]; other site 1052588009186 G-X-G motif; other site 1052588009187 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052588009188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588009189 active site 1052588009190 phosphorylation site [posttranslational modification] 1052588009191 intermolecular recognition site; other site 1052588009192 dimerization interface [polypeptide binding]; other site 1052588009193 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052588009194 DNA binding site [nucleotide binding] 1052588009195 hypothetical protein; Provisional; Region: PRK14082 1052588009196 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1052588009197 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588009198 DNA binding residues [nucleotide binding] 1052588009199 YvrJ protein family; Region: YvrJ; pfam12841 1052588009200 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1052588009201 Cupin domain; Region: Cupin_2; cl09118 1052588009202 Cupin domain; Region: Cupin_2; cl09118 1052588009203 Regulatory protein YrvL; Region: YrvL; pfam14184 1052588009204 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1052588009205 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1052588009206 FtsX-like permease family; Region: FtsX; cl15850 1052588009207 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052588009208 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1052588009209 Walker A/P-loop; other site 1052588009210 ATP binding site [chemical binding]; other site 1052588009211 Q-loop/lid; other site 1052588009212 ABC transporter signature motif; other site 1052588009213 Walker B; other site 1052588009214 D-loop; other site 1052588009215 H-loop/switch region; other site 1052588009216 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 1052588009217 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1052588009218 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1052588009219 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1052588009220 Walker A/P-loop; other site 1052588009221 ATP binding site [chemical binding]; other site 1052588009222 Q-loop/lid; other site 1052588009223 ABC transporter signature motif; other site 1052588009224 Walker B; other site 1052588009225 D-loop; other site 1052588009226 H-loop/switch region; other site 1052588009227 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052588009228 ABC-ATPase subunit interface; other site 1052588009229 dimer interface [polypeptide binding]; other site 1052588009230 putative PBP binding regions; other site 1052588009231 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052588009232 ABC-ATPase subunit interface; other site 1052588009233 dimer interface [polypeptide binding]; other site 1052588009234 putative PBP binding regions; other site 1052588009235 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1052588009236 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1052588009237 putative ligand binding residues [chemical binding]; other site 1052588009238 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1052588009239 Small spore protein J (Spore_SspJ); Region: Spore_SspJ; cl09798 1052588009240 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 1052588009241 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1052588009242 Sulfatase; Region: Sulfatase; cl10460 1052588009243 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1052588009244 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1052588009245 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1052588009246 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1052588009247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588009248 dimer interface [polypeptide binding]; other site 1052588009249 conserved gate region; other site 1052588009250 putative PBP binding loops; other site 1052588009251 ABC-ATPase subunit interface; other site 1052588009252 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052588009253 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052588009254 active site 1052588009255 catalytic tetrad [active] 1052588009256 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1052588009257 Synaptonemal complex protein 1 (SCP-1); Region: SCP-1; pfam05483 1052588009258 sulfite reductase subunit beta; Provisional; Region: PRK13504 1052588009259 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1052588009260 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1052588009261 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 1052588009262 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1052588009263 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1052588009264 FAD binding pocket [chemical binding]; other site 1052588009265 FAD binding motif [chemical binding]; other site 1052588009266 catalytic residues [active] 1052588009267 NAD binding pocket [chemical binding]; other site 1052588009268 phosphate binding motif [ion binding]; other site 1052588009269 beta-alpha-beta structure motif; other site 1052588009270 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1052588009271 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588009272 Family description; Region: UvrD_C_2; cl15862 1052588009273 UPF0126 domain; Region: UPF0126; pfam03458 1052588009274 UPF0126 domain; Region: UPF0126; pfam03458 1052588009275 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 1052588009276 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1052588009277 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1052588009278 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1052588009279 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1052588009280 metal-binding site [ion binding] 1052588009281 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1052588009282 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1052588009283 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1052588009284 metal-binding site [ion binding] 1052588009285 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1052588009286 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1052588009287 metal-binding site [ion binding] 1052588009288 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1052588009289 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1052588009290 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1052588009291 metal-binding site [ion binding] 1052588009292 Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157 1052588009293 putative homodimer interface [polypeptide binding]; other site 1052588009294 putative homotetramer interface [polypeptide binding]; other site 1052588009295 allosteric switch controlling residues; other site 1052588009296 putative metal binding site [ion binding]; other site 1052588009297 putative homodimer-homodimer interface [polypeptide binding]; other site 1052588009298 putative oxidoreductase; Provisional; Region: PRK11579 1052588009299 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588009300 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1052588009301 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1052588009302 Predicted membrane protein [Function unknown]; Region: COG1289 1052588009303 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1052588009304 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 1052588009305 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1052588009306 Helix-turn-helix domains; Region: HTH; cl00088 1052588009307 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1052588009308 classical (c) SDRs; Region: SDR_c; cd05233 1052588009309 NAD(P) binding site [chemical binding]; other site 1052588009310 active site 1052588009311 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1052588009312 SmpB-tmRNA interface; other site 1052588009313 ribonuclease R; Region: RNase_R; TIGR02063 1052588009314 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1052588009315 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1052588009316 RNB domain; Region: RNB; pfam00773 1052588009317 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 1052588009318 RNA binding site [nucleotide binding]; other site 1052588009319 Esterase/lipase [General function prediction only]; Region: COG1647 1052588009320 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052588009321 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052588009322 sequence-specific DNA binding site [nucleotide binding]; other site 1052588009323 salt bridge; other site 1052588009324 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052588009325 non-specific DNA binding site [nucleotide binding]; other site 1052588009326 salt bridge; other site 1052588009327 sequence-specific DNA binding site [nucleotide binding]; other site 1052588009328 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052588009329 non-specific DNA binding site [nucleotide binding]; other site 1052588009330 salt bridge; other site 1052588009331 sequence-specific DNA binding site [nucleotide binding]; other site 1052588009332 Helix-turn-helix domains; Region: HTH; cl00088 1052588009333 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1052588009334 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052588009335 dimerization interface [polypeptide binding]; other site 1052588009336 proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785 1052588009337 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052588009338 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052588009339 dimer interface [polypeptide binding]; other site 1052588009340 putative CheW interface [polypeptide binding]; other site 1052588009341 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588009342 dimer interface [polypeptide binding]; other site 1052588009343 conserved gate region; other site 1052588009344 putative PBP binding loops; other site 1052588009345 ABC-ATPase subunit interface; other site 1052588009346 NMT1-like family; Region: NMT1_2; cl15260 1052588009347 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1052588009348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588009349 dimer interface [polypeptide binding]; other site 1052588009350 conserved gate region; other site 1052588009351 putative PBP binding loops; other site 1052588009352 ABC-ATPase subunit interface; other site 1052588009353 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 1052588009354 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1052588009355 Walker A/P-loop; other site 1052588009356 ATP binding site [chemical binding]; other site 1052588009357 Q-loop/lid; other site 1052588009358 ABC transporter signature motif; other site 1052588009359 Walker B; other site 1052588009360 D-loop; other site 1052588009361 H-loop/switch region; other site 1052588009362 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1052588009363 Predicted transcriptional regulators [Transcription]; Region: COG1510 1052588009364 Helix-turn-helix domains; Region: HTH; cl00088 1052588009365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588009366 dimer interface [polypeptide binding]; other site 1052588009367 conserved gate region; other site 1052588009368 putative PBP binding loops; other site 1052588009369 ABC-ATPase subunit interface; other site 1052588009370 NMT1-like family; Region: NMT1_2; cl15260 1052588009371 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1052588009372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588009373 dimer interface [polypeptide binding]; other site 1052588009374 conserved gate region; other site 1052588009375 putative PBP binding loops; other site 1052588009376 ABC-ATPase subunit interface; other site 1052588009377 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 1052588009378 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1052588009379 Walker A/P-loop; other site 1052588009380 ATP binding site [chemical binding]; other site 1052588009381 Q-loop/lid; other site 1052588009382 ABC transporter signature motif; other site 1052588009383 Walker B; other site 1052588009384 D-loop; other site 1052588009385 H-loop/switch region; other site 1052588009386 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1052588009387 Predicted transcriptional regulators [Transcription]; Region: COG1510 1052588009388 Helix-turn-helix domains; Region: HTH; cl00088 1052588009389 MarC family integral membrane protein; Region: MarC; cl00919 1052588009390 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 1052588009391 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 1052588009392 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1052588009393 Predicted membrane protein [Function unknown]; Region: COG4640 1052588009394 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1052588009395 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588009396 Coenzyme A binding pocket [chemical binding]; other site 1052588009397 enolase; Provisional; Region: eno; PRK00077 1052588009398 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1052588009399 dimer interface [polypeptide binding]; other site 1052588009400 metal binding site [ion binding]; metal-binding site 1052588009401 substrate binding pocket [chemical binding]; other site 1052588009402 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1052588009403 Sulfatase; Region: Sulfatase; cl10460 1052588009404 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1052588009405 substrate binding site [chemical binding]; other site 1052588009406 dimer interface [polypeptide binding]; other site 1052588009407 catalytic triad [active] 1052588009408 Phosphoglycerate kinase; Region: PGK; pfam00162 1052588009409 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1052588009410 substrate binding site [chemical binding]; other site 1052588009411 hinge regions; other site 1052588009412 ADP binding site [chemical binding]; other site 1052588009413 catalytic site [active] 1052588009414 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1052588009415 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588009416 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1052588009417 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1052588009418 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1052588009419 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1052588009420 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588009421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588009422 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588009423 DNA-binding site [nucleotide binding]; DNA binding site 1052588009424 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052588009425 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 1052588009426 putative dimerization interface [polypeptide binding]; other site 1052588009427 putative ligand binding site [chemical binding]; other site 1052588009428 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1052588009429 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1052588009430 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052588009431 Helix-turn-helix domains; Region: HTH; cl00088 1052588009432 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052588009433 dimerization interface [polypeptide binding]; other site 1052588009434 EamA-like transporter family; Region: EamA; cl01037 1052588009435 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1052588009436 EamA-like transporter family; Region: EamA; cl01037 1052588009437 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1052588009438 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1052588009439 active site 1052588009440 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 1052588009441 iron-sulfur cluster-binding protein; Region: TIGR00273 1052588009442 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 1052588009443 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1052588009444 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 1052588009445 Cysteine-rich domain; Region: CCG; pfam02754 1052588009446 Cysteine-rich domain; Region: CCG; pfam02754 1052588009447 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052588009448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588009449 active site 1052588009450 phosphorylation site [posttranslational modification] 1052588009451 intermolecular recognition site; other site 1052588009452 dimerization interface [polypeptide binding]; other site 1052588009453 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052588009454 DNA binding residues [nucleotide binding] 1052588009455 dimerization interface [polypeptide binding]; other site 1052588009456 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052588009457 Histidine kinase; Region: HisKA_3; pfam07730 1052588009458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1052588009459 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1052588009460 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052588009461 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1052588009462 Walker A/P-loop; other site 1052588009463 ATP binding site [chemical binding]; other site 1052588009464 Q-loop/lid; other site 1052588009465 ABC transporter signature motif; other site 1052588009466 Walker B; other site 1052588009467 D-loop; other site 1052588009468 H-loop/switch region; other site 1052588009469 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052588009470 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052588009471 PAS domain S-box; Region: sensory_box; TIGR00229 1052588009472 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052588009473 putative active site [active] 1052588009474 heme pocket [chemical binding]; other site 1052588009475 Guanylate-binding protein, C-terminal domain; Region: GBP_C; pfam02841 1052588009476 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 1052588009477 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1052588009478 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 1052588009479 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1052588009480 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 1052588009481 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1052588009482 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1052588009483 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 1052588009484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588009485 dimer interface [polypeptide binding]; other site 1052588009486 conserved gate region; other site 1052588009487 putative PBP binding loops; other site 1052588009488 ABC-ATPase subunit interface; other site 1052588009489 TM2 domain; Region: TM2; cl00984 1052588009490 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052588009491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588009492 dimer interface [polypeptide binding]; other site 1052588009493 conserved gate region; other site 1052588009494 ABC-ATPase subunit interface; other site 1052588009495 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1052588009496 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1052588009497 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052588009498 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052588009499 DNA binding site [nucleotide binding] 1052588009500 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1052588009501 putative dimerization interface [polypeptide binding]; other site 1052588009502 putative ligand binding site [chemical binding]; other site 1052588009503 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1052588009504 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588009505 DNA-binding site [nucleotide binding]; DNA binding site 1052588009506 FCD domain; Region: FCD; cl11656 1052588009507 glycolate transporter; Provisional; Region: PRK09695 1052588009508 L-lactate permease; Region: Lactate_perm; cl00701 1052588009509 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 1052588009510 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1052588009511 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1052588009512 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1052588009513 YvfG protein; Region: YvfG; pfam09628 1052588009514 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1052588009515 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1052588009516 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1052588009517 inhibitor-cofactor binding pocket; inhibition site 1052588009518 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588009519 catalytic residue [active] 1052588009520 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1052588009521 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1052588009522 putative trimer interface [polypeptide binding]; other site 1052588009523 putative CoA binding site [chemical binding]; other site 1052588009524 Bacterial sugar transferase; Region: Bac_transf; cl00939 1052588009525 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1052588009526 MatE; Region: MatE; cl10513 1052588009527 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052588009528 active site 1052588009529 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1052588009530 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052588009531 active site 1052588009532 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052588009533 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 1052588009534 putative ADP-binding pocket [chemical binding]; other site 1052588009535 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1052588009536 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052588009537 active site 1052588009538 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1052588009539 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052588009540 putative ADP-binding pocket [chemical binding]; other site 1052588009541 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1052588009542 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1052588009543 NAD(P) binding site [chemical binding]; other site 1052588009544 homodimer interface [polypeptide binding]; other site 1052588009545 substrate binding site [chemical binding]; other site 1052588009546 active site 1052588009547 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1052588009548 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588009549 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1052588009550 Chain length determinant protein; Region: Wzz; cl15801 1052588009551 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052588009552 non-specific DNA binding site [nucleotide binding]; other site 1052588009553 salt bridge; other site 1052588009554 sequence-specific DNA binding site [nucleotide binding]; other site 1052588009555 Anti-repressor SinI; Region: SinI; pfam08671 1052588009556 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1052588009557 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1052588009558 substrate binding pocket [chemical binding]; other site 1052588009559 catalytic triad [active] 1052588009560 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 1052588009561 Protein of unknown function (DUF3237); Region: DUF3237; cl07905 1052588009562 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1052588009563 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052588009564 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1052588009565 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 1052588009566 active site 1052588009567 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1052588009568 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1052588009569 substrate binding [chemical binding]; other site 1052588009570 active site 1052588009571 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1052588009572 amino acid transporter; Region: 2A0306; TIGR00909 1052588009573 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052588009574 Helix-turn-helix domains; Region: HTH; cl00088 1052588009575 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1052588009576 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1052588009577 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 1052588009578 Clp protease; Region: CLP_protease; pfam00574 1052588009579 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1052588009580 oligomer interface [polypeptide binding]; other site 1052588009581 active site residues [active] 1052588009582 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1052588009583 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588009584 motif II; other site 1052588009585 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1052588009586 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1052588009587 Ca binding site [ion binding]; other site 1052588009588 active site 1052588009589 catalytic site [active] 1052588009590 maltose phosphorylase; Provisional; Region: PRK13807 1052588009591 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1052588009592 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1052588009593 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1052588009594 Predicted integral membrane protein [Function unknown]; Region: COG5521 1052588009595 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 1052588009596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588009597 dimer interface [polypeptide binding]; other site 1052588009598 conserved gate region; other site 1052588009599 ABC-ATPase subunit interface; other site 1052588009600 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052588009601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588009602 dimer interface [polypeptide binding]; other site 1052588009603 conserved gate region; other site 1052588009604 putative PBP binding loops; other site 1052588009605 ABC-ATPase subunit interface; other site 1052588009606 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1052588009607 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1052588009608 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1052588009609 homodimer interface [polypeptide binding]; other site 1052588009610 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1052588009611 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1052588009612 active site 1052588009613 homodimer interface [polypeptide binding]; other site 1052588009614 catalytic site [active] 1052588009615 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052588009616 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052588009617 DNA binding site [nucleotide binding] 1052588009618 domain linker motif; other site 1052588009619 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1052588009620 ligand binding site [chemical binding]; other site 1052588009621 dimerization interface [polypeptide binding]; other site 1052588009622 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1052588009623 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 1052588009624 metal binding site [ion binding]; metal-binding site 1052588009625 Sulfate transporter family; Region: Sulfate_transp; cl15842 1052588009626 putative transporter; Provisional; Region: PRK11660 1052588009627 Sulfate transporter family; Region: Sulfate_transp; cl15842 1052588009628 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1052588009629 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1052588009630 active site clefts [active] 1052588009631 zinc binding site [ion binding]; other site 1052588009632 dimer interface [polypeptide binding]; other site 1052588009633 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1052588009634 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588009635 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052588009636 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1052588009637 Walker A/P-loop; other site 1052588009638 ATP binding site [chemical binding]; other site 1052588009639 Q-loop/lid; other site 1052588009640 ABC transporter signature motif; other site 1052588009641 Walker B; other site 1052588009642 D-loop; other site 1052588009643 H-loop/switch region; other site 1052588009644 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1052588009645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588009646 ATP binding site [chemical binding]; other site 1052588009647 Mg2+ binding site [ion binding]; other site 1052588009648 G-X-G motif; other site 1052588009649 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052588009650 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588009651 active site 1052588009652 phosphorylation site [posttranslational modification] 1052588009653 intermolecular recognition site; other site 1052588009654 dimerization interface [polypeptide binding]; other site 1052588009655 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052588009656 DNA binding site [nucleotide binding] 1052588009657 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1052588009658 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1052588009659 dimerization domain swap beta strand [polypeptide binding]; other site 1052588009660 regulatory protein interface [polypeptide binding]; other site 1052588009661 active site 1052588009662 regulatory phosphorylation site [posttranslational modification]; other site 1052588009663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1052588009664 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1052588009665 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1052588009666 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1052588009667 phosphate binding site [ion binding]; other site 1052588009668 putative substrate binding pocket [chemical binding]; other site 1052588009669 dimer interface [polypeptide binding]; other site 1052588009670 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 1052588009671 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 1052588009672 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1052588009673 putative active site [active] 1052588009674 nucleotide binding site [chemical binding]; other site 1052588009675 nudix motif; other site 1052588009676 putative metal binding site [ion binding]; other site 1052588009677 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1052588009678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588009679 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052588009680 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1052588009681 NlpC/P60 family; Region: NLPC_P60; cl11438 1052588009682 Integrase core domain; Region: rve; cl01316 1052588009683 HTH-like domain; Region: HTH_21; pfam13276 1052588009684 Helix-turn-helix domains; Region: HTH; cl00088 1052588009685 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588009686 binding surface 1052588009687 TPR motif; other site 1052588009688 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1052588009689 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588009690 TPR motif; other site 1052588009691 binding surface 1052588009692 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052588009693 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1052588009694 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588009695 Walker A/P-loop; other site 1052588009696 ATP binding site [chemical binding]; other site 1052588009697 Q-loop/lid; other site 1052588009698 ABC transporter signature motif; other site 1052588009699 Walker B; other site 1052588009700 D-loop; other site 1052588009701 H-loop/switch region; other site 1052588009702 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 1052588009703 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1052588009704 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 1052588009705 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1052588009706 metal binding site [ion binding]; metal-binding site 1052588009707 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1052588009708 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1052588009709 substrate binding site [chemical binding]; other site 1052588009710 glutamase interaction surface [polypeptide binding]; other site 1052588009711 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1052588009712 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1052588009713 catalytic residues [active] 1052588009714 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1052588009715 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1052588009716 putative active site [active] 1052588009717 oxyanion strand; other site 1052588009718 catalytic triad [active] 1052588009719 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 1052588009720 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1052588009721 putative active site pocket [active] 1052588009722 4-fold oligomerization interface [polypeptide binding]; other site 1052588009723 metal binding residues [ion binding]; metal-binding site 1052588009724 3-fold/trimer interface [polypeptide binding]; other site 1052588009725 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1052588009726 histidinol dehydrogenase; Region: hisD; TIGR00069 1052588009727 NAD binding site [chemical binding]; other site 1052588009728 dimerization interface [polypeptide binding]; other site 1052588009729 product binding site; other site 1052588009730 substrate binding site [chemical binding]; other site 1052588009731 zinc binding site [ion binding]; other site 1052588009732 catalytic residues [active] 1052588009733 ATP phosphoribosyltransferase; Region: HisG; cl15266 1052588009734 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 1052588009735 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 1052588009736 dimer interface [polypeptide binding]; other site 1052588009737 motif 1; other site 1052588009738 active site 1052588009739 motif 2; other site 1052588009740 motif 3; other site 1052588009741 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 1052588009742 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 1052588009743 putative active site [active] 1052588009744 Pectate lyase; Region: Pectate_lyase; pfam03211 1052588009745 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1052588009746 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1052588009747 CoA binding site [chemical binding]; other site 1052588009748 active site 1052588009749 pyrophosphatase PpaX; Provisional; Region: PRK13288 1052588009750 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588009751 motif II; other site 1052588009752 Nucleoside recognition; Region: Gate; cl00486 1052588009753 Nucleoside recognition; Region: Gate; cl00486 1052588009754 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 1052588009755 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 1052588009756 DRTGG domain; Region: DRTGG; cl12147 1052588009757 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1052588009758 Hpr binding site; other site 1052588009759 active site 1052588009760 homohexamer subunit interaction site [polypeptide binding]; other site 1052588009761 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1052588009762 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1052588009763 active site 1052588009764 dimer interface [polypeptide binding]; other site 1052588009765 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1052588009766 active site 1052588009767 trimer interface [polypeptide binding]; other site 1052588009768 allosteric site; other site 1052588009769 active site lid [active] 1052588009770 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1052588009771 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1052588009772 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588009773 DNA-binding site [nucleotide binding]; DNA binding site 1052588009774 UTRA domain; Region: UTRA; cl01230 1052588009775 Lamin Tail Domain; Region: LTD; pfam00932 1052588009776 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 1052588009777 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1052588009778 putative active site [active] 1052588009779 putative metal binding site [ion binding]; other site 1052588009780 Membrane protein of unknown function; Region: DUF360; cl00850 1052588009781 PspC domain; Region: PspC; cl00864 1052588009782 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1052588009783 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1052588009784 flagellin; Provisional; Region: PRK12804 1052588009785 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1052588009786 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1052588009787 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 1052588009788 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 1052588009789 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 1052588009790 excinuclease ABC subunit B; Provisional; Region: PRK05298 1052588009791 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052588009792 ATP binding site [chemical binding]; other site 1052588009793 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052588009794 nucleotide binding region [chemical binding]; other site 1052588009795 ATP-binding site [chemical binding]; other site 1052588009796 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1052588009797 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 1052588009798 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 1052588009799 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1052588009800 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1052588009801 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052588009802 Helix-turn-helix domains; Region: HTH; cl00088 1052588009803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588009804 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588009805 putative substrate translocation pore; other site 1052588009806 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1052588009807 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1052588009808 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1052588009809 C-terminal peptidase (prc); Region: prc; TIGR00225 1052588009810 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1052588009811 protein binding site [polypeptide binding]; other site 1052588009812 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1052588009813 Catalytic dyad [active] 1052588009814 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1052588009815 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1052588009816 FtsX-like permease family; Region: FtsX; cl15850 1052588009817 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1052588009818 FtsE is a hydrophilic nucleotide-binding protein that binds FtsX to form a heterodimeric ATP-binding cassette (ABC)-type transporter that associates with the bacterial inner membrane. The FtsE/X transporter is thought to be involved in cell division and...; Region: ABC_FtsE_transporter; cd03292 1052588009819 Walker A/P-loop; other site 1052588009820 ATP binding site [chemical binding]; other site 1052588009821 Q-loop/lid; other site 1052588009822 ABC transporter signature motif; other site 1052588009823 Walker B; other site 1052588009824 D-loop; other site 1052588009825 H-loop/switch region; other site 1052588009826 Cytochrome c; Region: Cytochrom_C; cl11414 1052588009827 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1052588009828 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052588009829 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052588009830 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 1052588009831 peptide chain release factor 2; Provisional; Region: PRK06746 1052588009832 RF-1 domain; Region: RF-1; cl02875 1052588009833 RF-1 domain; Region: RF-1; cl02875 1052588009834 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1052588009835 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588009836 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 1052588009837 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588009838 SEC-C motif; Region: SEC-C; pfam02810 1052588009839 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 1052588009840 30S subunit binding site; other site 1052588009841 Flagellar protein FliT; Region: FliT; cl05125 1052588009842 Flagellar protein FliS; Region: FliS; cl00654 1052588009843 flagellar capping protein; Validated; Region: fliD; PRK07737 1052588009844 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1052588009845 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1052588009846 FlaG protein; Region: FlaG; cl00591 1052588009847 flagellin; Provisional; Region: PRK12804 1052588009848 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1052588009849 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1052588009850 Global regulator protein family; Region: CsrA; cl00670 1052588009851 FliW protein; Region: FliW; cl00740 1052588009852 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 1052588009853 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1052588009854 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1052588009855 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 1052588009856 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1052588009857 FlgN protein; Region: FlgN; cl09176 1052588009858 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 1052588009859 flagellar operon protein TIGR03826; Region: YvyF 1052588009860 comF family protein; Region: comF; TIGR00201 1052588009861 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052588009862 active site 1052588009863 Late competence development protein ComFB; Region: ComFB; pfam10719 1052588009864 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1052588009865 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052588009866 ATP binding site [chemical binding]; other site 1052588009867 putative Mg++ binding site [ion binding]; other site 1052588009868 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052588009869 nucleotide binding region [chemical binding]; other site 1052588009870 ATP-binding site [chemical binding]; other site 1052588009871 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 1052588009872 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052588009873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588009874 active site 1052588009875 phosphorylation site [posttranslational modification] 1052588009876 intermolecular recognition site; other site 1052588009877 dimerization interface [polypeptide binding]; other site 1052588009878 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052588009879 DNA binding residues [nucleotide binding] 1052588009880 dimerization interface [polypeptide binding]; other site 1052588009881 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052588009882 Histidine kinase; Region: HisKA_3; pfam07730 1052588009883 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588009884 ATP binding site [chemical binding]; other site 1052588009885 Mg2+ binding site [ion binding]; other site 1052588009886 G-X-G motif; other site 1052588009887 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 1052588009888 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1052588009889 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1052588009890 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1052588009891 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1052588009892 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1052588009893 Mg++ binding site [ion binding]; other site 1052588009894 putative catalytic motif [active] 1052588009895 substrate binding site [chemical binding]; other site 1052588009896 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1052588009897 putative homodimer interface [polypeptide binding]; other site 1052588009898 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052588009899 active site 1052588009900 Chain length determinant protein; Region: Wzz; cl15801 1052588009901 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 1052588009902 O-Antigen ligase; Region: Wzy_C; cl04850 1052588009903 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1052588009904 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588009905 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1052588009906 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588009907 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052588009908 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1052588009909 colanic acid exporter; Provisional; Region: PRK10459 1052588009910 MatE; Region: MatE; cl10513 1052588009911 Bacterial sugar transferase; Region: Bac_transf; cl00939 1052588009912 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 1052588009913 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1052588009914 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1052588009915 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1052588009916 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1052588009917 active site 1052588009918 metal binding site [ion binding]; metal-binding site 1052588009919 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1052588009920 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 1052588009921 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1052588009922 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1052588009923 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 1052588009924 Stage II sporulation protein; Region: SpoIID; pfam08486 1052588009925 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 1052588009926 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1052588009927 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1052588009928 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1052588009929 active site 1052588009930 homodimer interface [polypeptide binding]; other site 1052588009931 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1052588009932 active site 1052588009933 tetramer interface; other site 1052588009934 teichoic acids export protein ATP-binding subunit; Provisional; Region: tagH; PRK13545 1052588009935 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 1052588009936 Walker A/P-loop; other site 1052588009937 ATP binding site [chemical binding]; other site 1052588009938 Q-loop/lid; other site 1052588009939 ABC transporter signature motif; other site 1052588009940 Walker B; other site 1052588009941 D-loop; other site 1052588009942 H-loop/switch region; other site 1052588009943 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1052588009944 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1052588009945 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1052588009946 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1052588009947 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052588009948 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 1052588009949 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1052588009950 active site 1052588009951 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1052588009952 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1052588009953 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1052588009954 Bacterial SH3 domain; Region: SH3_3; cl02551 1052588009955 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1052588009956 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1052588009957 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 1052588009958 Spore germination protein; Region: Spore_permease; cl15802 1052588009959 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 1052588009960 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1052588009961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588009962 putative substrate translocation pore; other site 1052588009963 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1052588009964 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588009965 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1052588009966 active site 1052588009967 motif I; other site 1052588009968 motif II; other site 1052588009969 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1052588009970 NlpC/P60 family; Region: NLPC_P60; cl11438 1052588009971 NlpC/P60 family; Region: NLPC_P60; cl11438 1052588009972 NlpC/P60 family; Region: NLPC_P60; cl11438 1052588009973 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1052588009974 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1052588009975 putative active site [active] 1052588009976 putative metal binding site [ion binding]; other site 1052588009977 Capsule biosynthesis CapC; Region: Caps_synth_CapC; cl14855 1052588009978 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 1052588009979 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1052588009980 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052588009981 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052588009982 DNA binding site [nucleotide binding] 1052588009983 domain linker motif; other site 1052588009984 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1052588009985 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1052588009986 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1052588009987 substrate binding site [chemical binding]; other site 1052588009988 dimer interface [polypeptide binding]; other site 1052588009989 ATP binding site [chemical binding]; other site 1052588009990 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 1052588009991 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1052588009992 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 1052588009993 Walker A/P-loop; other site 1052588009994 ATP binding site [chemical binding]; other site 1052588009995 Q-loop/lid; other site 1052588009996 ABC transporter signature motif; other site 1052588009997 Walker B; other site 1052588009998 D-loop; other site 1052588009999 H-loop/switch region; other site 1052588010000 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 1052588010001 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1052588010002 TM-ABC transporter signature motif; other site 1052588010003 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1052588010004 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1052588010005 ligand binding site [chemical binding]; other site 1052588010006 dimerization interface [polypeptide binding]; other site 1052588010007 Bacterial SH3 domain; Region: SH3_3; cl02551 1052588010008 Bacterial SH3 domain; Region: SH3_3; cl02551 1052588010009 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 1052588010010 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1052588010011 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 1052588010012 acetolactate synthase; Reviewed; Region: PRK08617 1052588010013 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1052588010014 PYR/PP interface [polypeptide binding]; other site 1052588010015 dimer interface [polypeptide binding]; other site 1052588010016 TPP binding site [chemical binding]; other site 1052588010017 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1052588010018 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1052588010019 TPP-binding site [chemical binding]; other site 1052588010020 dimer interface [polypeptide binding]; other site 1052588010021 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1052588010022 Helix-turn-helix domains; Region: HTH; cl00088 1052588010023 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 1052588010024 putative dimerization interface [polypeptide binding]; other site 1052588010025 putative substrate binding pocket [chemical binding]; other site 1052588010026 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1052588010027 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1052588010028 transmembrane helices; other site 1052588010029 Spore coat assembly protein [Cell envelope biogenesis, outer membrane]; Region: CotH; COG5337 1052588010030 Flavin Reductases; Region: FlaRed; cl00801 1052588010031 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 1052588010032 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1052588010033 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1052588010034 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1052588010035 Helix-turn-helix domains; Region: HTH; cl00088 1052588010036 AsnC family; Region: AsnC_trans_reg; pfam01037 1052588010037 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1052588010038 Chromate transporter; Region: Chromate_transp; pfam02417 1052588010039 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1052588010040 Chromate transporter; Region: Chromate_transp; pfam02417 1052588010041 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1052588010042 Active_site [active] 1052588010043 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1052588010044 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 1052588010045 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 1052588010046 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1052588010047 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588010048 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1052588010049 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588010050 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1052588010051 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1052588010052 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588010053 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1052588010054 Chain length determinant protein; Region: Wzz; cl15801 1052588010055 SWIM zinc finger; Region: SWIM; cl15408 1052588010056 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1052588010057 SNF2 Helicase protein; Region: DUF3670; pfam12419 1052588010058 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052588010059 ATP binding site [chemical binding]; other site 1052588010060 putative Mg++ binding site [ion binding]; other site 1052588010061 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052588010062 nucleotide binding region [chemical binding]; other site 1052588010063 ATP-binding site [chemical binding]; other site 1052588010064 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588010065 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1052588010066 active site 1052588010067 motif I; other site 1052588010068 motif II; other site 1052588010069 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1052588010070 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1052588010071 Helix-turn-helix domains; Region: HTH; cl00088 1052588010072 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1052588010073 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1052588010074 dimer interface [polypeptide binding]; other site 1052588010075 ssDNA binding site [nucleotide binding]; other site 1052588010076 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052588010077 YwpF-like protein; Region: YwpF; pfam14183 1052588010078 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1052588010079 active site 1052588010080 catalytic site [active] 1052588010081 Collagen binding domain; Region: Collagen_bind; pfam05737 1052588010082 Collagen binding domain; Region: Collagen_bind; pfam05737 1052588010083 Collagen binding domain; Region: Collagen_bind; pfam05737 1052588010084 Collagen binding domain; Region: Collagen_bind; pfam05737 1052588010085 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1052588010086 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1052588010087 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1052588010088 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1052588010089 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1052588010090 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1052588010091 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1052588010092 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1052588010093 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 1052588010094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588010095 active site 1052588010096 phosphorylation site [posttranslational modification] 1052588010097 intermolecular recognition site; other site 1052588010098 dimerization interface [polypeptide binding]; other site 1052588010099 Helix-turn-helix domains; Region: HTH; cl00088 1052588010100 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1052588010101 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052588010102 dimer interface [polypeptide binding]; other site 1052588010103 phosphorylation site [posttranslational modification] 1052588010104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588010105 ATP binding site [chemical binding]; other site 1052588010106 Mg2+ binding site [ion binding]; other site 1052588010107 G-X-G motif; other site 1052588010108 Response regulator receiver domain; Region: Response_reg; pfam00072 1052588010109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588010110 active site 1052588010111 phosphorylation site [posttranslational modification] 1052588010112 intermolecular recognition site; other site 1052588010113 dimerization interface [polypeptide binding]; other site 1052588010114 Histidine kinase; Region: His_kinase; pfam06580 1052588010115 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588010116 ATP binding site [chemical binding]; other site 1052588010117 Mg2+ binding site [ion binding]; other site 1052588010118 G-X-G motif; other site 1052588010119 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 1052588010120 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1052588010121 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1052588010122 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1052588010123 binding surface 1052588010124 TPR motif; other site 1052588010125 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1052588010126 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1052588010127 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1052588010128 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1052588010129 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 1052588010130 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1052588010131 rod shape-determining protein Mbl; Provisional; Region: PRK13928 1052588010132 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 1052588010133 ATP binding site [chemical binding]; other site 1052588010134 profilin binding site; other site 1052588010135 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1052588010136 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588010137 Helix-turn-helix domains; Region: HTH; cl00088 1052588010138 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588010139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588010140 putative substrate translocation pore; other site 1052588010141 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1052588010142 Right handed beta helix region; Region: Beta_helix; pfam13229 1052588010143 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 1052588010144 Na binding site [ion binding]; other site 1052588010145 putative substrate binding site [chemical binding]; other site 1052588010146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588010147 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588010148 putative substrate translocation pore; other site 1052588010149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588010150 Isochorismatase family; Region: Isochorismatase; pfam00857 1052588010151 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1052588010152 catalytic triad [active] 1052588010153 conserved cis-peptide bond; other site 1052588010154 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 1052588010155 Nitrogen regulatory protein P-II; Region: P-II; cl00412 1052588010156 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1052588010157 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1052588010158 active site 1052588010159 VanZ like family; Region: VanZ; cl01971 1052588010160 Peptidase family M23; Region: Peptidase_M23; pfam01551 1052588010161 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1052588010162 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588010163 Coenzyme A binding pocket [chemical binding]; other site 1052588010164 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1052588010165 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1052588010166 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1052588010167 putative active site [active] 1052588010168 catalytic site [active] 1052588010169 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1052588010170 putative active site [active] 1052588010171 catalytic site [active] 1052588010172 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1052588010173 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1052588010174 DNA binding residues [nucleotide binding] 1052588010175 dimer interface [polypeptide binding]; other site 1052588010176 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1052588010177 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1052588010178 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1052588010179 NAD binding site [chemical binding]; other site 1052588010180 substrate binding site [chemical binding]; other site 1052588010181 putative active site [active] 1052588010182 Predicted transcriptional regulator [Transcription]; Region: COG1959 1052588010183 Helix-turn-helix domains; Region: HTH; cl00088 1052588010184 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1052588010185 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1052588010186 subunit interactions [polypeptide binding]; other site 1052588010187 active site 1052588010188 flap region; other site 1052588010189 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1052588010190 gamma-beta subunit interface [polypeptide binding]; other site 1052588010191 alpha-beta subunit interface [polypeptide binding]; other site 1052588010192 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1052588010193 alpha-gamma subunit interface [polypeptide binding]; other site 1052588010194 beta-gamma subunit interface [polypeptide binding]; other site 1052588010195 potential frameshift: common BLAST hit: gi|350267927|ref|YP_004879234.1| ABC transporter 1052588010196 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588010197 Walker B; other site 1052588010198 D-loop; other site 1052588010199 H-loop/switch region; other site 1052588010200 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588010201 Walker A/P-loop; other site 1052588010202 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1052588010203 CsbD-like; Region: CsbD; cl15799 1052588010204 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052588010205 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1052588010206 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1052588010207 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052588010208 FeS/SAM binding site; other site 1052588010209 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1052588010210 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 1052588010211 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1052588010212 metal ion-dependent adhesion site (MIDAS); other site 1052588010213 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1052588010214 metal ion-dependent adhesion site (MIDAS); other site 1052588010215 stage II sporulation protein D; Region: spore_II_D; TIGR02870 1052588010216 Stage II sporulation protein; Region: SpoIID; pfam08486 1052588010217 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1052588010218 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1052588010219 hinge; other site 1052588010220 active site 1052588010221 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 1052588010222 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 1052588010223 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1052588010224 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 1052588010225 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 1052588010226 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1052588010227 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 1052588010228 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1052588010229 alpha subunit interaction interface [polypeptide binding]; other site 1052588010230 Walker A motif; other site 1052588010231 ATP binding site [chemical binding]; other site 1052588010232 Walker B motif; other site 1052588010233 inhibitor binding site; inhibition site 1052588010234 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1052588010235 ATP synthase; Region: ATP-synt; cl00365 1052588010236 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 1052588010237 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1052588010238 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 1052588010239 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1052588010240 beta subunit interaction interface [polypeptide binding]; other site 1052588010241 Walker A motif; other site 1052588010242 ATP binding site [chemical binding]; other site 1052588010243 Walker B motif; other site 1052588010244 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1052588010245 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 1052588010246 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1052588010247 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 1052588010248 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1052588010249 ATP synthase A chain; Region: ATP-synt_A; cl00413 1052588010250 ATP synthase I chain; Region: ATP_synt_I; cl09170 1052588010251 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052588010252 active site 1052588010253 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1052588010254 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1052588010255 dimer interface [polypeptide binding]; other site 1052588010256 active site 1052588010257 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1052588010258 folate binding site [chemical binding]; other site 1052588010259 Protein of unknown function (DUF436); Region: DUF436; cl01860 1052588010260 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 1052588010261 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1052588010262 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1052588010263 active site 1052588010264 Predicted membrane protein [Function unknown]; Region: COG1971 1052588010265 Domain of unknown function DUF; Region: DUF204; pfam02659 1052588010266 Domain of unknown function DUF; Region: DUF204; pfam02659 1052588010267 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1052588010268 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1052588010269 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052588010270 HemK family putative methylases; Region: hemK_fam; TIGR00536 1052588010271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588010272 S-adenosylmethionine binding site [chemical binding]; other site 1052588010273 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1052588010274 RF-1 domain; Region: RF-1; cl02875 1052588010275 RF-1 domain; Region: RF-1; cl02875 1052588010276 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1052588010277 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052588010278 putative metal binding site [ion binding]; other site 1052588010279 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 1052588010280 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1052588010281 DNA binding residues [nucleotide binding] 1052588010282 Membrane transport protein; Region: Mem_trans; cl09117 1052588010283 malate dehydrogenase; Provisional; Region: PRK13529 1052588010284 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1052588010285 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1052588010286 NAD(P) binding site [chemical binding]; other site 1052588010287 thymidine kinase; Provisional; Region: PRK04296 1052588010288 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 1052588010289 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1052588010290 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1052588010291 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1052588010292 RNA binding site [nucleotide binding]; other site 1052588010293 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1052588010294 multimer interface [polypeptide binding]; other site 1052588010295 Walker A motif; other site 1052588010296 ATP binding site [chemical binding]; other site 1052588010297 Walker B motif; other site 1052588010298 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1052588010299 putative active site [active] 1052588010300 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1052588010301 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1052588010302 hinge; other site 1052588010303 active site 1052588010304 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1052588010305 active site 1052588010306 intersubunit interactions; other site 1052588010307 catalytic residue [active] 1052588010308 hypothetical protein; Provisional; Region: PRK08185 1052588010309 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1052588010310 intersubunit interface [polypeptide binding]; other site 1052588010311 active site 1052588010312 zinc binding site [ion binding]; other site 1052588010313 Na+ binding site [ion binding]; other site 1052588010314 Response regulator receiver domain; Region: Response_reg; pfam00072 1052588010315 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588010316 active site 1052588010317 phosphorylation site [posttranslational modification] 1052588010318 intermolecular recognition site; other site 1052588010319 dimerization interface [polypeptide binding]; other site 1052588010320 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 1052588010321 CTP synthetase; Validated; Region: pyrG; PRK05380 1052588010322 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1052588010323 Catalytic site [active] 1052588010324 active site 1052588010325 UTP binding site [chemical binding]; other site 1052588010326 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1052588010327 active site 1052588010328 putative oxyanion hole; other site 1052588010329 catalytic triad [active] 1052588010330 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 1052588010331 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1052588010332 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1052588010333 FAD binding site [chemical binding]; other site 1052588010334 homotetramer interface [polypeptide binding]; other site 1052588010335 substrate binding pocket [chemical binding]; other site 1052588010336 catalytic base [active] 1052588010337 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 1052588010338 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1052588010339 Cysteine-rich domain; Region: CCG; pfam02754 1052588010340 Cysteine-rich domain; Region: CCG; pfam02754 1052588010341 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1052588010342 putative active site [active] 1052588010343 catalytic site [active] 1052588010344 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1052588010345 PLD-like domain; Region: PLDc_2; pfam13091 1052588010346 putative active site [active] 1052588010347 catalytic site [active] 1052588010348 UV-endonuclease UvdE; Region: UvdE; cl10036 1052588010349 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1052588010350 folate binding site [chemical binding]; other site 1052588010351 NADP+ binding site [chemical binding]; other site 1052588010352 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052588010353 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1052588010354 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 1052588010355 Walker A/P-loop; other site 1052588010356 ATP binding site [chemical binding]; other site 1052588010357 Q-loop/lid; other site 1052588010358 ABC transporter signature motif; other site 1052588010359 Walker B; other site 1052588010360 D-loop; other site 1052588010361 H-loop/switch region; other site 1052588010362 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1052588010363 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1052588010364 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1052588010365 putative active site [active] 1052588010366 catalytic site [active] 1052588010367 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1052588010368 putative active site [active] 1052588010369 catalytic site [active] 1052588010370 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 1052588010371 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1052588010372 nitrate reductase, beta subunit; Region: narH; TIGR01660 1052588010373 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 1052588010374 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1052588010375 [4Fe-4S] binding site [ion binding]; other site 1052588010376 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1052588010377 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1052588010378 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1052588010379 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1052588010380 molybdopterin cofactor binding site; other site 1052588010381 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1052588010382 ligand binding site [chemical binding]; other site 1052588010383 flexible hinge region; other site 1052588010384 YwiC-like protein; Region: YwiC; pfam14256 1052588010385 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1052588010386 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1052588010387 ligand binding site [chemical binding]; other site 1052588010388 flexible hinge region; other site 1052588010389 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1052588010390 putative switch regulator; other site 1052588010391 non-specific DNA interactions [nucleotide binding]; other site 1052588010392 DNA binding site [nucleotide binding] 1052588010393 sequence specific DNA binding site [nucleotide binding]; other site 1052588010394 putative cAMP binding site [chemical binding]; other site 1052588010395 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1052588010396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588010397 putative substrate translocation pore; other site 1052588010398 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1052588010399 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 1052588010400 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1052588010401 active site 1052588010402 HIGH motif; other site 1052588010403 KMSK motif region; other site 1052588010404 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1052588010405 tRNA binding surface [nucleotide binding]; other site 1052588010406 anticodon binding site; other site 1052588010407 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 1052588010408 Bacteriocin subtilosin A; Region: Subtilosin_A; pfam11420 1052588010409 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1052588010410 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1052588010411 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052588010412 FeS/SAM binding site; other site 1052588010413 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 1052588010414 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1052588010415 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1052588010416 Walker A/P-loop; other site 1052588010417 ATP binding site [chemical binding]; other site 1052588010418 Q-loop/lid; other site 1052588010419 ABC transporter signature motif; other site 1052588010420 Walker B; other site 1052588010421 D-loop; other site 1052588010422 H-loop/switch region; other site 1052588010423 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1052588010424 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1052588010425 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1052588010426 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1052588010427 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1052588010428 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1052588010429 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1052588010430 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1052588010431 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1052588010432 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052588010433 TPR motif; other site 1052588010434 binding surface 1052588010435 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052588010436 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1052588010437 putative deacylase active site [active] 1052588010438 Arginase family; Region: Arginase; cl00306 1052588010439 spermidine synthase; Provisional; Region: PRK00811 1052588010440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1052588010441 Transglycosylase; Region: Transgly; cl07896 1052588010442 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1052588010443 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052588010444 YwhD family; Region: YwhD; pfam08741 1052588010445 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1052588010446 active site 1052588010447 putative substrate binding region [chemical binding]; other site 1052588010448 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1052588010449 active site 1 [active] 1052588010450 dimer interface [polypeptide binding]; other site 1052588010451 hexamer interface [polypeptide binding]; other site 1052588010452 active site 2 [active] 1052588010453 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588010454 Helix-turn-helix domains; Region: HTH; cl00088 1052588010455 Helix-turn-helix domains; Region: HTH; cl00088 1052588010456 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 1052588010457 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1052588010458 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 1052588010459 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1052588010460 active site 1052588010461 dimer interface [polypeptide binding]; other site 1052588010462 motif 1; other site 1052588010463 motif 2; other site 1052588010464 motif 3; other site 1052588010465 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1052588010466 anticodon binding site; other site 1052588010467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588010468 D-galactonate transporter; Region: 2A0114; TIGR00893 1052588010469 putative substrate translocation pore; other site 1052588010470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588010471 Rrf2 family protein; Region: rrf2_super; TIGR00738 1052588010472 Helix-turn-helix domains; Region: HTH; cl00088 1052588010473 Uncharacterized conserved protein [Function unknown]; Region: COG3465 1052588010474 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1052588010475 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052588010476 Zn2+ binding site [ion binding]; other site 1052588010477 Mg2+ binding site [ion binding]; other site 1052588010478 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1052588010479 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1052588010480 EamA-like transporter family; Region: EamA; cl01037 1052588010481 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1052588010482 EamA-like transporter family; Region: EamA; cl01037 1052588010483 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1052588010484 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1052588010485 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052588010486 Helix-turn-helix domains; Region: HTH; cl00088 1052588010487 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1052588010488 putative dimerization interface [polypeptide binding]; other site 1052588010489 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 1052588010490 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1052588010491 Chlorite dismutase; Region: Chlor_dismutase; cl01280 1052588010492 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1052588010493 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1052588010494 putative NAD(P) binding site [chemical binding]; other site 1052588010495 putative active site [active] 1052588010496 transaminase; Reviewed; Region: PRK08068 1052588010497 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052588010498 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588010499 homodimer interface [polypeptide binding]; other site 1052588010500 catalytic residue [active] 1052588010501 H+ Antiporter protein; Region: 2A0121; TIGR00900 1052588010502 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 1052588010503 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1052588010504 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1052588010505 classical (c) SDRs; Region: SDR_c; cd05233 1052588010506 NAD(P) binding site [chemical binding]; other site 1052588010507 active site 1052588010508 Cupin domain; Region: Cupin_2; cl09118 1052588010509 Cupin domain; Region: Cupin_2; cl09118 1052588010510 Prephenate dehydratase; Region: PDT; pfam00800 1052588010511 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052588010512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588010513 putative substrate translocation pore; other site 1052588010514 S-methylmethionine transporter; Provisional; Region: PRK11387 1052588010515 Spore germination protein; Region: Spore_permease; cl15802 1052588010516 Arginine degradation protein (predicted deacylase) [Amino acid transport and metabolism]; Region: RocB; COG4187 1052588010517 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 1052588010518 putative metal binding site [ion binding]; other site 1052588010519 putative dimer interface [polypeptide binding]; other site 1052588010520 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1052588010521 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1052588010522 Glutamate binding site [chemical binding]; other site 1052588010523 homodimer interface [polypeptide binding]; other site 1052588010524 NAD binding site [chemical binding]; other site 1052588010525 catalytic residues [active] 1052588010526 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1052588010527 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1052588010528 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1052588010529 NAD(P) binding site [chemical binding]; other site 1052588010530 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1052588010531 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1052588010532 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 1052588010533 NAD binding site [chemical binding]; other site 1052588010534 substrate binding site [chemical binding]; other site 1052588010535 homodimer interface [polypeptide binding]; other site 1052588010536 active site 1052588010537 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1052588010538 substrate binding site; other site 1052588010539 tetramer interface; other site 1052588010540 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 1052588010541 ligand binding site; other site 1052588010542 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 1052588010543 NeuB family; Region: NeuB; cl00496 1052588010544 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1052588010545 NeuB binding interface [polypeptide binding]; other site 1052588010546 putative substrate binding site [chemical binding]; other site 1052588010547 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1052588010548 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052588010549 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1052588010550 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1052588010551 inhibitor-cofactor binding pocket; inhibition site 1052588010552 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588010553 catalytic residue [active] 1052588010554 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1052588010555 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1052588010556 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052588010557 active site 1052588010558 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; cl09881 1052588010559 Protein of unknown function (DUF423); Region: DUF423; cl01008 1052588010560 Permease family; Region: Xan_ur_permease; pfam00860 1052588010561 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1052588010562 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1052588010563 NAD(P) binding site [chemical binding]; other site 1052588010564 catalytic residues [active] 1052588010565 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1052588010566 ligand binding site [chemical binding]; other site 1052588010567 active site 1052588010568 UGI interface [polypeptide binding]; other site 1052588010569 catalytic site [active] 1052588010570 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052588010571 active site 1052588010572 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1052588010573 dimer interface [polypeptide binding]; other site 1052588010574 substrate binding site [chemical binding]; other site 1052588010575 ATP binding site [chemical binding]; other site 1052588010576 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1052588010577 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1052588010578 substrate binding [chemical binding]; other site 1052588010579 active site 1052588010580 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1052588010581 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1052588010582 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052588010583 active site turn [active] 1052588010584 phosphorylation site [posttranslational modification] 1052588010585 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1052588010586 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 1052588010587 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1052588010588 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1052588010589 putative active site [active] 1052588010590 catalytic triad [active] 1052588010591 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1052588010592 PA/protease domain interface [polypeptide binding]; other site 1052588010593 putative integrin binding motif; other site 1052588010594 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1052588010595 FlgD Ig-like domain; Region: FlgD_ig; cl15790 1052588010596 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1052588010597 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1052588010598 Bacterial protein of unknown function (HtrL_YibB); Region: HtrL_YibB; cl08171 1052588010599 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1052588010600 dimer interface [polypeptide binding]; other site 1052588010601 FMN binding site [chemical binding]; other site 1052588010602 NADPH bind site [chemical binding]; other site 1052588010603 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1052588010604 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 1052588010605 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1052588010606 Subunit I/III interface [polypeptide binding]; other site 1052588010607 Subunit III/IV interface [polypeptide binding]; other site 1052588010608 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1052588010609 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1052588010610 D-pathway; other site 1052588010611 Putative ubiquinol binding site [chemical binding]; other site 1052588010612 Low-spin heme (heme b) binding site [chemical binding]; other site 1052588010613 Putative water exit pathway; other site 1052588010614 Binuclear center (heme o3/CuB) [ion binding]; other site 1052588010615 K-pathway; other site 1052588010616 Putative proton exit pathway; other site 1052588010617 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1052588010618 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1052588010619 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1052588010620 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1052588010621 galactose-1-phosphate uridylyltransferase, family 2; Region: galT_2; TIGR01239 1052588010622 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1052588010623 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1052588010624 galactokinase; Provisional; Region: PRK05322 1052588010625 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1052588010626 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1052588010627 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1052588010628 GtrA-like protein; Region: GtrA; cl00971 1052588010629 Helix-turn-helix domains; Region: HTH; cl00088 1052588010630 Anti-repressor SinI; Region: SinI; pfam08671 1052588010631 Protein of unknown function, DUF485; Region: DUF485; cl01231 1052588010632 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1052588010633 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1052588010634 Na binding site [ion binding]; other site 1052588010635 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1052588010636 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1052588010637 catalytic residues [active] 1052588010638 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1052588010639 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1052588010640 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 1052588010641 Imelysin; Region: Peptidase_M75; cl09159 1052588010642 reticulocyte binding/rhoptry protein; Region: 235kDa-fam; TIGR01612 1052588010643 Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases; Region: HR1; cl00087 1052588010644 Iron permease FTR1 family; Region: FTR1; cl00475 1052588010645 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1052588010646 thiamine phosphate binding site [chemical binding]; other site 1052588010647 active site 1052588010648 pyrophosphate binding site [ion binding]; other site 1052588010649 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1052588010650 substrate binding site [chemical binding]; other site 1052588010651 multimerization interface [polypeptide binding]; other site 1052588010652 ATP binding site [chemical binding]; other site 1052588010653 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052588010654 Helix-turn-helix domains; Region: HTH; cl00088 1052588010655 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1052588010656 putative dimerization interface [polypeptide binding]; other site 1052588010657 LrgA family; Region: LrgA; cl00608 1052588010658 LrgB-like family; Region: LrgB; cl00596 1052588010659 sugar efflux transporter; Region: 2A0120; TIGR00899 1052588010660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588010661 putative substrate translocation pore; other site 1052588010662 Uncharacterized conserved protein (DUF2196); Region: DUF2196; cl02044 1052588010663 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1052588010664 PUA domain; Region: PUA; cl00607 1052588010665 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1052588010666 putative RNA binding site [nucleotide binding]; other site 1052588010667 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1052588010668 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052588010669 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1052588010670 active site 1052588010671 metal binding site [ion binding]; metal-binding site 1052588010672 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1052588010673 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1052588010674 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1052588010675 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1052588010676 active site 1052588010677 catalytic residues [active] 1052588010678 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1052588010679 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052588010680 active site turn [active] 1052588010681 phosphorylation site [posttranslational modification] 1052588010682 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1052588010683 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1052588010684 CAT RNA binding domain; Region: CAT_RBD; cl03904 1052588010685 PRD domain; Region: PRD; cl15445 1052588010686 PRD domain; Region: PRD; cl15445 1052588010687 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1052588010688 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1052588010689 Ligand binding site; other site 1052588010690 metal-binding site 1052588010691 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; cl02331 1052588010692 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588010693 Helix-turn-helix domains; Region: HTH; cl00088 1052588010694 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 1052588010695 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1052588010696 active site 1052588010697 HIGH motif; other site 1052588010698 dimer interface [polypeptide binding]; other site 1052588010699 KMSKS motif; other site 1052588010700 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1052588010701 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1052588010702 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1052588010703 PA/protease domain interface [polypeptide binding]; other site 1052588010704 putative integrin binding motif; other site 1052588010705 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1052588010706 metal binding site [ion binding]; metal-binding site 1052588010707 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1052588010708 synthetase active site [active] 1052588010709 NTP binding site [chemical binding]; other site 1052588010710 metal binding site [ion binding]; metal-binding site 1052588010711 UbiA prenyltransferase family; Region: UbiA; cl00337 1052588010712 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1052588010713 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1052588010714 AMP-binding enzyme; Region: AMP-binding; cl15778 1052588010715 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 1052588010716 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052588010717 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 1052588010718 DltD N-terminal region; Region: DltD_N; pfam04915 1052588010719 DltD central region; Region: DltD_M; pfam04918 1052588010720 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1052588010721 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1052588010722 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 1052588010723 putative NAD(P) binding site [chemical binding]; other site 1052588010724 active site 1052588010725 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1052588010726 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1052588010727 homodimer interface [polypeptide binding]; other site 1052588010728 substrate-cofactor binding pocket; other site 1052588010729 catalytic residue [active] 1052588010730 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1052588010731 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1052588010732 NAD binding site [chemical binding]; other site 1052588010733 sugar binding site [chemical binding]; other site 1052588010734 divalent metal binding site [ion binding]; other site 1052588010735 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052588010736 dimer interface [polypeptide binding]; other site 1052588010737 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1052588010738 methionine cluster; other site 1052588010739 active site 1052588010740 phosphorylation site [posttranslational modification] 1052588010741 metal binding site [ion binding]; metal-binding site 1052588010742 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1052588010743 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1052588010744 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1052588010745 active site 1052588010746 P-loop; other site 1052588010747 phosphorylation site [posttranslational modification] 1052588010748 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1052588010749 Helix-turn-helix domains; Region: HTH; cl00088 1052588010750 Helix-turn-helix domains; Region: HTH; cl00088 1052588010751 PRD domain; Region: PRD; cl15445 1052588010752 PRD domain; Region: PRD; cl15445 1052588010753 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1052588010754 active site 1052588010755 P-loop; other site 1052588010756 phosphorylation site [posttranslational modification] 1052588010757 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1052588010758 active site 1052588010759 phosphorylation site [posttranslational modification] 1052588010760 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1052588010761 active site 1052588010762 DNA binding site [nucleotide binding] 1052588010763 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1052588010764 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1052588010765 tetramer interface [polypeptide binding]; other site 1052588010766 heme binding pocket [chemical binding]; other site 1052588010767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588010768 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588010769 putative substrate translocation pore; other site 1052588010770 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1052588010771 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052588010772 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588010773 Walker A/P-loop; other site 1052588010774 ATP binding site [chemical binding]; other site 1052588010775 Q-loop/lid; other site 1052588010776 ABC transporter signature motif; other site 1052588010777 Walker B; other site 1052588010778 D-loop; other site 1052588010779 H-loop/switch region; other site 1052588010780 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1052588010781 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1052588010782 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 1052588010783 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 1052588010784 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052588010785 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052588010786 DNA binding residues [nucleotide binding] 1052588010787 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1052588010788 Na binding site [ion binding]; other site 1052588010789 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1052588010790 putative substrate binding site [chemical binding]; other site 1052588010791 putative ATP binding site [chemical binding]; other site 1052588010792 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1052588010793 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1052588010794 The CYD subfamily implicated in cytochrome bd biogenesis. The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd...; Region: ABCC_cytochrome_bd; cd03247 1052588010795 Walker A/P-loop; other site 1052588010796 ATP binding site [chemical binding]; other site 1052588010797 Q-loop/lid; other site 1052588010798 ABC transporter signature motif; other site 1052588010799 Walker B; other site 1052588010800 D-loop; other site 1052588010801 H-loop/switch region; other site 1052588010802 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1052588010803 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1052588010804 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588010805 ATP binding site [chemical binding]; other site 1052588010806 Q-loop/lid; other site 1052588010807 ABC transporter signature motif; other site 1052588010808 Walker B; other site 1052588010809 D-loop; other site 1052588010810 H-loop/switch region; other site 1052588010811 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1052588010812 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1052588010813 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1052588010814 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1052588010815 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 1052588010816 Peptidase family M48; Region: Peptidase_M48; cl12018 1052588010817 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1052588010818 putative active site [active] 1052588010819 putative metal binding site [ion binding]; other site 1052588010820 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1052588010821 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 1052588010822 Walker A/P-loop; other site 1052588010823 ATP binding site [chemical binding]; other site 1052588010824 Q-loop/lid; other site 1052588010825 ABC transporter signature motif; other site 1052588010826 Walker B; other site 1052588010827 D-loop; other site 1052588010828 H-loop/switch region; other site 1052588010829 TOBE domain; Region: TOBE_2; cl01440 1052588010830 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1052588010831 Helix-turn-helix domains; Region: HTH; cl00088 1052588010832 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1052588010833 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1052588010834 NAD(P) binding site [chemical binding]; other site 1052588010835 catalytic residues [active] 1052588010836 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1052588010837 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052588010838 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 1052588010839 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1052588010840 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1052588010841 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1052588010842 UDP-glucose 4-epimerase; Region: PLN02240 1052588010843 NAD binding site [chemical binding]; other site 1052588010844 homodimer interface [polypeptide binding]; other site 1052588010845 active site 1052588010846 substrate binding site [chemical binding]; other site 1052588010847 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1052588010848 substrate binding site [chemical binding]; other site 1052588010849 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052588010850 Helix-turn-helix domains; Region: HTH; cl00088 1052588010851 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052588010852 dimerization interface [polypeptide binding]; other site 1052588010853 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052588010854 Histidine kinase; Region: HisKA_3; pfam07730 1052588010855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588010856 ATP binding site [chemical binding]; other site 1052588010857 Mg2+ binding site [ion binding]; other site 1052588010858 G-X-G motif; other site 1052588010859 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052588010860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588010861 active site 1052588010862 phosphorylation site [posttranslational modification] 1052588010863 intermolecular recognition site; other site 1052588010864 dimerization interface [polypeptide binding]; other site 1052588010865 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052588010866 DNA binding residues [nucleotide binding] 1052588010867 dimerization interface [polypeptide binding]; other site 1052588010868 peptidase T; Region: peptidase-T; TIGR01882 1052588010869 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1052588010870 metal binding site [ion binding]; metal-binding site 1052588010871 dimer interface [polypeptide binding]; other site 1052588010872 Scramblase; Region: Scramblase; cl02043 1052588010873 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1052588010874 substrate binding site [chemical binding]; other site 1052588010875 THF binding site; other site 1052588010876 zinc-binding site [ion binding]; other site 1052588010877 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1052588010878 substrate binding site [chemical binding]; other site 1052588010879 THF binding site; other site 1052588010880 zinc-binding site [ion binding]; other site 1052588010881 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 1052588010882 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 1052588010883 NAD binding site [chemical binding]; other site 1052588010884 homotetramer interface [polypeptide binding]; other site 1052588010885 homodimer interface [polypeptide binding]; other site 1052588010886 substrate binding site [chemical binding]; other site 1052588010887 active site 1052588010888 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1052588010889 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1052588010890 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1052588010891 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1052588010892 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 1052588010893 nucleoside transporter; Region: nupC; TIGR00804 1052588010894 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1052588010895 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1052588010896 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1052588010897 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1052588010898 hydroperoxidase II; Provisional; Region: katE; PRK11249 1052588010899 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1052588010900 tetramer interface [polypeptide binding]; other site 1052588010901 heme binding pocket [chemical binding]; other site 1052588010902 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1052588010903 domain interactions; other site 1052588010904 Citrate transporter; Region: CitMHS; pfam03600 1052588010905 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1052588010906 transmembrane helices; other site 1052588010907 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 1052588010908 active site 1052588010909 active site 1052588010910 catalytic residues [active] 1052588010911 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1052588010912 CAT RNA binding domain; Region: CAT_RBD; cl03904 1052588010913 PRD domain; Region: PRD; cl15445 1052588010914 PRD domain; Region: PRD; cl15445 1052588010915 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1052588010916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588010917 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1052588010918 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1052588010919 ATP binding site [chemical binding]; other site 1052588010920 Mg++ binding site [ion binding]; other site 1052588010921 motif III; other site 1052588010922 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052588010923 nucleotide binding region [chemical binding]; other site 1052588010924 ATP-binding site [chemical binding]; other site 1052588010925 DbpA RNA binding domain; Region: DbpA; pfam03880 1052588010926 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 1052588010927 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1052588010928 active site 1052588010929 catalytic triad [active] 1052588010930 Helix-turn-helix domains; Region: HTH; cl00088 1052588010931 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 1052588010932 RHS Repeat; Region: RHS_repeat; cl11982 1052588010933 RHS Repeat; Region: RHS_repeat; cl11982 1052588010934 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1052588010935 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1052588010936 RHS Repeat; Region: RHS_repeat; cl11982 1052588010937 RHS Repeat; Region: RHS_repeat; cl11982 1052588010938 RHS Repeat; Region: RHS_repeat; cl11982 1052588010939 RHS Repeat; Region: RHS_repeat; cl11982 1052588010940 RHS Repeat; Region: RHS_repeat; cl11982 1052588010941 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1052588010942 EamA-like transporter family; Region: EamA; cl01037 1052588010943 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1052588010944 EamA-like transporter family; Region: EamA; cl01037 1052588010945 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1052588010946 Ligand Binding Site [chemical binding]; other site 1052588010947 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1052588010948 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1052588010949 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052588010950 active site turn [active] 1052588010951 phosphorylation site [posttranslational modification] 1052588010952 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1052588010953 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1052588010954 HPr interaction site; other site 1052588010955 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1052588010956 active site 1052588010957 phosphorylation site [posttranslational modification] 1052588010958 LXG domain of WXG superfamily; Region: LXG; pfam04740 1052588010959 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1052588010960 active site 1052588010961 8-oxo-dGMP binding site [chemical binding]; other site 1052588010962 nudix motif; other site 1052588010963 metal binding site [ion binding]; metal-binding site 1052588010964 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 1052588010965 substrate binding site [chemical binding]; other site 1052588010966 active site 1052588010967 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 1052588010968 hexamer interface [polypeptide binding]; other site 1052588010969 RNA binding site [nucleotide binding]; other site 1052588010970 Histidine-zinc binding site [chemical binding]; other site 1052588010971 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1052588010972 active sites [active] 1052588010973 tetramer interface [polypeptide binding]; other site 1052588010974 urocanate hydratase; Provisional; Region: PRK05414 1052588010975 imidazolonepropionase; Validated; Region: PRK09356 1052588010976 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1052588010977 active site 1052588010978 Arginase family; Region: Arginase; cl00306 1052588010979 S-methylmethionine transporter; Provisional; Region: PRK11387 1052588010980 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1052588010981 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1052588010982 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1052588010983 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 1052588010984 nucleoside transporter; Region: nupC; TIGR00804 1052588010985 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1052588010986 Nucleoside recognition; Region: Gate; cl00486 1052588010987 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1052588010988 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1052588010989 intersubunit interface [polypeptide binding]; other site 1052588010990 active site 1052588010991 catalytic residue [active] 1052588010992 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1052588010993 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1052588010994 Helix-turn-helix domains; Region: HTH; cl00088 1052588010995 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1052588010996 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1052588010997 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1052588010998 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1052588010999 Ethanolamine utilisation protein, EutH; Region: EutH; cl01248 1052588011000 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1052588011001 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1052588011002 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1052588011003 metal binding site [ion binding]; metal-binding site 1052588011004 dimer interface [polypeptide binding]; other site 1052588011005 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1052588011006 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1052588011007 Walker A/P-loop; other site 1052588011008 ATP binding site [chemical binding]; other site 1052588011009 Q-loop/lid; other site 1052588011010 ABC transporter signature motif; other site 1052588011011 Walker B; other site 1052588011012 D-loop; other site 1052588011013 H-loop/switch region; other site 1052588011014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052588011015 dimer interface [polypeptide binding]; other site 1052588011016 conserved gate region; other site 1052588011017 putative PBP binding loops; other site 1052588011018 ABC-ATPase subunit interface; other site 1052588011019 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1052588011020 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1052588011021 substrate binding pocket [chemical binding]; other site 1052588011022 membrane-bound complex binding site; other site 1052588011023 hinge residues; other site 1052588011024 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588011025 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1052588011026 Coenzyme A binding pocket [chemical binding]; other site 1052588011027 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1052588011028 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1052588011029 active site 1052588011030 non-prolyl cis peptide bond; other site 1052588011031 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1052588011032 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1052588011033 active site 1052588011034 sugar phosphate phosphatase; Provisional; Region: PRK10513 1052588011035 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588011036 active site 1052588011037 motif I; other site 1052588011038 motif II; other site 1052588011039 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052588011040 Protein of unknown function (DUF3255); Region: DUF3255; pfam11631 1052588011041 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1052588011042 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1052588011043 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1052588011044 putative ligand binding residues [chemical binding]; other site 1052588011045 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 1052588011046 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052588011047 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1052588011048 Walker A/P-loop; other site 1052588011049 ATP binding site [chemical binding]; other site 1052588011050 Q-loop/lid; other site 1052588011051 ABC transporter signature motif; other site 1052588011052 Walker B; other site 1052588011053 D-loop; other site 1052588011054 H-loop/switch region; other site 1052588011055 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1052588011056 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588011057 ATP binding site [chemical binding]; other site 1052588011058 Mg2+ binding site [ion binding]; other site 1052588011059 G-X-G motif; other site 1052588011060 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052588011061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588011062 active site 1052588011063 phosphorylation site [posttranslational modification] 1052588011064 intermolecular recognition site; other site 1052588011065 dimerization interface [polypeptide binding]; other site 1052588011066 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052588011067 DNA binding site [nucleotide binding] 1052588011068 hypothetical protein; Provisional; Region: PRK08185 1052588011069 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1052588011070 intersubunit interface [polypeptide binding]; other site 1052588011071 active site 1052588011072 zinc binding site [ion binding]; other site 1052588011073 Na+ binding site [ion binding]; other site 1052588011074 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1052588011075 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1052588011076 Metal-binding active site; metal-binding site 1052588011077 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1052588011078 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1052588011079 DNA interaction; other site 1052588011080 Metal-binding active site; metal-binding site 1052588011081 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052588011082 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588011083 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1052588011084 Glucuronate isomerase; Region: UxaC; cl00829 1052588011085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588011086 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052588011087 putative substrate translocation pore; other site 1052588011088 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1052588011089 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1052588011090 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1052588011091 PYR/PP interface [polypeptide binding]; other site 1052588011092 dimer interface [polypeptide binding]; other site 1052588011093 TPP binding site [chemical binding]; other site 1052588011094 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1052588011095 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1052588011096 TPP-binding site; other site 1052588011097 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1052588011098 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1052588011099 substrate binding site [chemical binding]; other site 1052588011100 ATP binding site [chemical binding]; other site 1052588011101 KduI/IolB family; Region: KduI; cl01508 1052588011102 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1052588011103 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1052588011104 tetrameric interface [polypeptide binding]; other site 1052588011105 NAD binding site [chemical binding]; other site 1052588011106 catalytic residues [active] 1052588011107 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1052588011108 Helix-turn-helix domains; Region: HTH; cl00088 1052588011109 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1052588011110 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1052588011111 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052588011112 active site 1052588011113 catalytic tetrad [active] 1052588011114 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 1052588011115 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1052588011116 CGNR zinc finger; Region: zf-CGNR; pfam11706 1052588011117 HPP family; Region: HPP; pfam04982 1052588011118 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1052588011119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588011120 putative substrate translocation pore; other site 1052588011121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588011122 heat shock protein 90; Provisional; Region: PRK05218 1052588011123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1052588011124 short chain dehydrogenase; Validated; Region: PRK08589 1052588011125 classical (c) SDRs; Region: SDR_c; cd05233 1052588011126 NAD(P) binding site [chemical binding]; other site 1052588011127 active site 1052588011128 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052588011129 Helix-turn-helix domains; Region: HTH; cl00088 1052588011130 Helix-turn-helix domains; Region: HTH; cl00088 1052588011131 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1052588011132 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 1052588011133 NAD(P) binding site [chemical binding]; other site 1052588011134 catalytic residues [active] 1052588011135 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1052588011136 catalytic tetrad [active] 1052588011137 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1052588011138 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1052588011139 DNA binding residues [nucleotide binding] 1052588011140 putative dimer interface [polypeptide binding]; other site 1052588011141 RDD family; Region: RDD; cl00746 1052588011142 Predicted membrane protein [Function unknown]; Region: COG2311 1052588011143 Protein of unknown function (DUF418); Region: DUF418; cl12135 1052588011144 Cupin domain; Region: Cupin_2; cl09118 1052588011145 Cupin domain; Region: Cupin_2; cl09118 1052588011146 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052588011147 Helix-turn-helix domains; Region: HTH; cl00088 1052588011148 short chain dehydrogenase; Provisional; Region: PRK07109 1052588011149 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1052588011150 putative NAD(P) binding site [chemical binding]; other site 1052588011151 active site 1052588011152 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588011153 Helix-turn-helix domains; Region: HTH; cl00088 1052588011154 LrgA family; Region: LrgA; cl00608 1052588011155 LrgB-like family; Region: LrgB; cl00596 1052588011156 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1052588011157 Glycerate kinase family; Region: Gly_kinase; cl00841 1052588011158 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1052588011159 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588011160 DNA-binding site [nucleotide binding]; DNA binding site 1052588011161 FCD domain; Region: FCD; cl11656 1052588011162 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1052588011163 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1052588011164 N- and C-terminal domain interface [polypeptide binding]; other site 1052588011165 putative active site [active] 1052588011166 catalytic site [active] 1052588011167 metal binding site [ion binding]; metal-binding site 1052588011168 carbohydrate binding site [chemical binding]; other site 1052588011169 ATP binding site [chemical binding]; other site 1052588011170 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 1052588011171 gluconate transporter; Region: gntP; TIGR00791 1052588011172 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd; TIGR00873 1052588011173 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588011174 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1052588011175 peroxiredoxin; Region: AhpC; TIGR03137 1052588011176 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1052588011177 dimer interface [polypeptide binding]; other site 1052588011178 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1052588011179 catalytic triad [active] 1052588011180 peroxidatic and resolving cysteines [active] 1052588011181 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1052588011182 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1052588011183 catalytic residue [active] 1052588011184 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1052588011185 catalytic residues [active] 1052588011186 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052588011187 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1052588011188 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1052588011189 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052588011190 active site turn [active] 1052588011191 phosphorylation site [posttranslational modification] 1052588011192 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1052588011193 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 1052588011194 HPr interaction site; other site 1052588011195 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1052588011196 active site 1052588011197 phosphorylation site [posttranslational modification] 1052588011198 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1052588011199 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052588011200 DNA-binding site [nucleotide binding]; DNA binding site 1052588011201 UTRA domain; Region: UTRA; cl01230 1052588011202 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1052588011203 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1052588011204 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588011205 Walker A/P-loop; other site 1052588011206 ATP binding site [chemical binding]; other site 1052588011207 ABC transporter signature motif; other site 1052588011208 Walker B; other site 1052588011209 D-loop; other site 1052588011210 H-loop/switch region; other site 1052588011211 peptide modification radical SAM enzyme, YydG family; Region: rSAM_yydG; TIGR04078 1052588011212 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052588011213 FeS/SAM binding site; other site 1052588011214 exported signaling peptide, YydF/SAG_2028 family; Region: expor_sig_YdyF; TIGR04077 1052588011215 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 1052588011216 HTH-like domain; Region: HTH_21; pfam13276 1052588011217 Integrase core domain; Region: rve; cl01316 1052588011218 RNA polymerase beta'' subunit; Reviewed; Region: rpoC2; CHL00117 1052588011219 Protein of unknown function (DUF524); Region: DUF524; pfam04411 1052588011220 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 1052588011221 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588011222 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 1052588011223 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 1052588011224 YyzF-like protein; Region: YyzF; cl15733 1052588011225 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 1052588011226 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 1052588011227 NAD binding site [chemical binding]; other site 1052588011228 catalytic Zn binding site [ion binding]; other site 1052588011229 structural Zn binding site [ion binding]; other site 1052588011230 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 1052588011231 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1052588011232 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1052588011233 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588011234 Coenzyme A binding pocket [chemical binding]; other site 1052588011235 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052588011236 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1052588011237 binding surface 1052588011238 TPR motif; other site 1052588011239 Arginase family; Region: Arginase; cl00306 1052588011240 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 1052588011241 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1052588011242 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052588011243 inhibitor-cofactor binding pocket; inhibition site 1052588011244 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052588011245 catalytic residue [active] 1052588011246 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1052588011247 sensory histidine kinase AtoS; Provisional; Region: PRK11360 1052588011248 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1052588011249 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052588011250 Walker A motif; other site 1052588011251 ATP binding site [chemical binding]; other site 1052588011252 Walker B motif; other site 1052588011253 arginine finger; other site 1052588011254 Helix-turn-helix domains; Region: HTH; cl00088 1052588011255 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 1052588011256 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1052588011257 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1052588011258 protein binding site [polypeptide binding]; other site 1052588011259 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052588011260 YycH protein; Region: YycI; cl02015 1052588011261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1052588011262 YycH protein; Region: YycH; pfam07435 1052588011263 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1052588011264 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052588011265 dimerization interface [polypeptide binding]; other site 1052588011266 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1052588011267 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052588011268 dimer interface [polypeptide binding]; other site 1052588011269 phosphorylation site [posttranslational modification] 1052588011270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052588011271 ATP binding site [chemical binding]; other site 1052588011272 Mg2+ binding site [ion binding]; other site 1052588011273 G-X-G motif; other site 1052588011274 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052588011275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052588011276 active site 1052588011277 phosphorylation site [posttranslational modification] 1052588011278 intermolecular recognition site; other site 1052588011279 dimerization interface [polypeptide binding]; other site 1052588011280 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052588011281 DNA binding site [nucleotide binding] 1052588011282 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1052588011283 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1052588011284 GDP-binding site [chemical binding]; other site 1052588011285 ACT binding site; other site 1052588011286 IMP binding site; other site 1052588011287 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052588011288 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1052588011289 active site 1052588011290 metal binding site [ion binding]; metal-binding site 1052588011291 replicative DNA helicase; Provisional; Region: PRK05748 1052588011292 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1052588011293 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1052588011294 Walker A motif; other site 1052588011295 ATP binding site [chemical binding]; other site 1052588011296 Walker B motif; other site 1052588011297 DNA binding loops [nucleotide binding] 1052588011298 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 1052588011299 YycC-like protein; Region: YycC; pfam14174 1052588011300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588011301 cyanate transporter; Region: CynX; TIGR00896 1052588011302 putative substrate translocation pore; other site 1052588011303 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 1052588011304 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1052588011305 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1052588011306 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1052588011307 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1052588011308 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1052588011309 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1052588011310 DHH family; Region: DHH; pfam01368 1052588011311 DHHA1 domain; Region: DHHA1; pfam02272 1052588011312 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 1052588011313 Coat F domain; Region: Coat_F; cl15836 1052588011314 Helix-turn-helix domains; Region: HTH; cl00088 1052588011315 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1052588011316 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1052588011317 DHHA2 domain; Region: DHHA2; pfam02833 1052588011318 ANTAR domain; Region: ANTAR; cl04297 1052588011319 D-galactonate transporter; Region: 2A0114; TIGR00893 1052588011320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588011321 putative substrate translocation pore; other site 1052588011322 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1052588011323 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1052588011324 DNA binding residues [nucleotide binding] 1052588011325 dimer interface [polypeptide binding]; other site 1052588011326 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1052588011327 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1052588011328 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1052588011329 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1052588011330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588011331 putative substrate translocation pore; other site 1052588011332 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052588011333 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052588011334 Helix-turn-helix domains; Region: HTH; cl00088 1052588011335 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1052588011336 putative dimerization interface [polypeptide binding]; other site 1052588011337 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052588011338 Coenzyme A binding pocket [chemical binding]; other site 1052588011339 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052588011340 Helix-turn-helix domains; Region: HTH; cl00088 1052588011341 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052588011342 dimerization interface [polypeptide binding]; other site 1052588011343 LysE type translocator; Region: LysE; cl00565 1052588011344 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1052588011345 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 1052588011346 dimer interface [polypeptide binding]; other site 1052588011347 metal binding site [ion binding]; metal-binding site 1052588011348 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052588011349 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052588011350 Helix-turn-helix domains; Region: HTH; cl00088 1052588011351 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052588011352 Predicted membrane protein [Function unknown]; Region: COG2364 1052588011353 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1052588011354 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1052588011355 catalytic residues [active] 1052588011356 CAAX protease self-immunity; Region: Abi; cl00558 1052588011357 benzoate transport; Region: 2A0115; TIGR00895 1052588011358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588011359 putative substrate translocation pore; other site 1052588011360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052588011361 maltose O-acetyltransferase; Provisional; Region: PRK10092 1052588011362 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1052588011363 active site 1052588011364 substrate binding site [chemical binding]; other site 1052588011365 trimer interface [polypeptide binding]; other site 1052588011366 CoA binding site [chemical binding]; other site 1052588011367 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052588011368 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 1052588011369 putative metal binding site [ion binding]; other site 1052588011370 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052588011371 DNA binding site [nucleotide binding] 1052588011372 domain linker motif; other site 1052588011373 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1052588011374 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1052588011375 putative dimerization interface [polypeptide binding]; other site 1052588011376 putative ligand binding site [chemical binding]; other site 1052588011377 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1052588011378 active site 1052588011379 putative catalytic site [active] 1052588011380 DNA binding site [nucleotide binding] 1052588011381 putative phosphate binding site [ion binding]; other site 1052588011382 metal binding site A [ion binding]; metal-binding site 1052588011383 AP binding site [nucleotide binding]; other site 1052588011384 metal binding site B [ion binding]; metal-binding site 1052588011385 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1052588011386 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1052588011387 dimer interface [polypeptide binding]; other site 1052588011388 ssDNA binding site [nucleotide binding]; other site 1052588011389 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052588011390 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 1052588011391 GTP-binding protein YchF; Reviewed; Region: PRK09601 1052588011392 YchF GTPase; Region: YchF; cd01900 1052588011393 G1 box; other site 1052588011394 GTP/Mg2+ binding site [chemical binding]; other site 1052588011395 Switch I region; other site 1052588011396 G2 box; other site 1052588011397 Switch II region; other site 1052588011398 G3 box; other site 1052588011399 G4 box; other site 1052588011400 G5 box; other site 1052588011401 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1052588011402 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1052588011403 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1052588011404 putative [4Fe-4S] binding site [ion binding]; other site 1052588011405 putative molybdopterin cofactor binding site [chemical binding]; other site 1052588011406 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1052588011407 molybdopterin cofactor binding site; other site 1052588011408 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 1052588011409 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1052588011410 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 1052588011411 ParB-like partition proteins; Region: parB_part; TIGR00180 1052588011412 ParB-like nuclease domain; Region: ParBc; cl02129 1052588011413 KorB domain; Region: KorB; pfam08535 1052588011414 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1052588011415 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052588011416 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 1052588011417 ParB-like partition proteins; Region: parB_part; TIGR00180 1052588011418 ParB-like nuclease domain; Region: ParBc; cl02129 1052588011419 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052588011420 S-adenosylmethionine binding site [chemical binding]; other site 1052588011421 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1052588011422 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052588011423 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1052588011424 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1052588011425 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1052588011426 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1052588011427 G1 box; other site 1052588011428 GTP/Mg2+ binding site [chemical binding]; other site 1052588011429 Switch I region; other site 1052588011430 G2 box; other site 1052588011431 Switch II region; other site 1052588011432 G3 box; other site 1052588011433 G4 box; other site 1052588011434 G5 box; other site 1052588011435 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1052588011436 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1052588011437 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1052588011438 G-X-X-G motif; other site 1052588011439 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1052588011440 RxxxH motif; other site 1052588011441 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1052588011442 Ribonuclease P; Region: Ribonuclease_P; cl00457