-- dump date 20120504_134328 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1052585000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1052585000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1052585000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585000004 Walker A motif; other site 1052585000005 ATP binding site [chemical binding]; other site 1052585000006 Walker B motif; other site 1052585000007 arginine finger; other site 1052585000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1052585000009 DnaA box-binding interface [nucleotide binding]; other site 1052585000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1052585000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1052585000012 putative DNA binding surface [nucleotide binding]; other site 1052585000013 dimer interface [polypeptide binding]; other site 1052585000014 beta-clamp/clamp loader binding surface; other site 1052585000015 beta-clamp/translesion DNA polymerase binding surface; other site 1052585000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1052585000017 recF protein; Region: recf; TIGR00611 1052585000018 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 1052585000019 Walker A/P-loop; other site 1052585000020 ATP binding site [chemical binding]; other site 1052585000021 Q-loop/lid; other site 1052585000022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585000023 ABC transporter signature motif; other site 1052585000024 Walker B; other site 1052585000025 D-loop; other site 1052585000026 H-loop/switch region; other site 1052585000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1052585000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585000029 ATP binding site [chemical binding]; other site 1052585000030 Mg2+ binding site [ion binding]; other site 1052585000031 G-X-G motif; other site 1052585000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1052585000033 anchoring element; other site 1052585000034 dimer interface [polypeptide binding]; other site 1052585000035 ATP binding site [chemical binding]; other site 1052585000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1052585000037 active site 1052585000038 putative metal-binding site [ion binding]; other site 1052585000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1052585000040 DNA gyrase subunit A; Validated; Region: PRK05560 1052585000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 1052585000042 CAP-like domain; other site 1052585000043 active site 1052585000044 primary dimer interface [polypeptide binding]; other site 1052585000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052585000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052585000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052585000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052585000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052585000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052585000051 YaaC-like Protein; Region: YaaC; pfam14175 1052585000052 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1052585000053 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1052585000054 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 1052585000055 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 1052585000056 active site 1052585000057 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1052585000058 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052585000059 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 1052585000060 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1052585000061 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1052585000062 active site 1052585000063 multimer interface [polypeptide binding]; other site 1052585000064 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1052585000065 predicted active site [active] 1052585000066 catalytic triad [active] 1052585000067 seryl-tRNA synthetase; Provisional; Region: PRK05431 1052585000068 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1052585000069 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 1052585000070 dimer interface [polypeptide binding]; other site 1052585000071 active site 1052585000072 motif 1; other site 1052585000073 motif 2; other site 1052585000074 motif 3; other site 1052585000075 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1052585000076 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1052585000077 Substrate-binding site [chemical binding]; other site 1052585000078 Substrate specificity [chemical binding]; other site 1052585000079 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1052585000080 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1052585000081 Substrate-binding site [chemical binding]; other site 1052585000082 Substrate specificity [chemical binding]; other site 1052585000083 Isochorismatase family; Region: Isochorismatase; pfam00857 1052585000084 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1052585000085 catalytic triad [active] 1052585000086 conserved cis-peptide bond; other site 1052585000087 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1052585000088 nucleoside/Zn binding site; other site 1052585000089 dimer interface [polypeptide binding]; other site 1052585000090 catalytic motif [active] 1052585000091 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1052585000092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585000093 Walker A motif; other site 1052585000094 ATP binding site [chemical binding]; other site 1052585000095 Walker B motif; other site 1052585000096 arginine finger; other site 1052585000097 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1052585000098 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 1052585000099 recombination protein RecR; Reviewed; Region: recR; PRK00076 1052585000100 RecR protein; Region: RecR; pfam02132 1052585000101 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1052585000102 putative active site [active] 1052585000103 putative metal-binding site [ion binding]; other site 1052585000104 tetramer interface [polypeptide binding]; other site 1052585000105 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1052585000106 SigmaK-factor processing regulatory protein BofA; Region: BofA; cl06466 1052585000107 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 1052585000108 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 1052585000109 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1052585000110 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1052585000111 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1052585000112 homodimer interface [polypeptide binding]; other site 1052585000113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585000114 catalytic residue [active] 1052585000115 thymidylate kinase; Validated; Region: tmk; PRK00698 1052585000116 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1052585000117 TMP-binding site; other site 1052585000118 ATP-binding site [chemical binding]; other site 1052585000119 Nitrogen regulatory protein P-II; Region: P-II; cl00412 1052585000120 Protein of unknown function (DUF327); Region: DUF327; cl00753 1052585000121 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1052585000122 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585000123 PSP1 C-terminal conserved region; Region: PSP1; cl00770 1052585000124 TSC-22/dip/bun family; Region: TSC22; cl01853 1052585000125 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1052585000126 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585000127 S-adenosylmethionine binding site [chemical binding]; other site 1052585000128 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1052585000129 GIY-YIG motif/motif A; other site 1052585000130 putative active site [active] 1052585000131 putative metal binding site [ion binding]; other site 1052585000132 Predicted methyltransferases [General function prediction only]; Region: COG0313 1052585000133 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1052585000134 stage V sporulation protein T; Region: spore_V_T; TIGR02851 1052585000135 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1052585000136 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1052585000137 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1052585000138 active site 1052585000139 HIGH motif; other site 1052585000140 KMSKS motif; other site 1052585000141 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1052585000142 tRNA binding surface [nucleotide binding]; other site 1052585000143 anticodon binding site; other site 1052585000144 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1052585000145 dimer interface [polypeptide binding]; other site 1052585000146 putative tRNA-binding site [nucleotide binding]; other site 1052585000147 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1052585000148 active site 1052585000149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1052585000150 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1052585000151 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1052585000152 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1052585000153 G5 domain; Region: G5; pfam07501 1052585000154 3D domain; Region: 3D; cl01439 1052585000155 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1052585000156 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1052585000157 putative active site [active] 1052585000158 putative metal binding site [ion binding]; other site 1052585000159 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1052585000160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585000161 S-adenosylmethionine binding site [chemical binding]; other site 1052585000162 YabG peptidase U57; Region: Peptidase_U57; cl05250 1052585000163 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 1052585000164 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1052585000165 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1052585000166 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1052585000167 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052585000168 active site 1052585000169 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1052585000170 homotrimer interaction site [polypeptide binding]; other site 1052585000171 putative active site [active] 1052585000172 SpoVG; Region: SpoVG; cl00915 1052585000173 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1052585000174 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1052585000175 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052585000176 active site 1052585000177 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1052585000178 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1052585000179 5S rRNA interface [nucleotide binding]; other site 1052585000180 CTC domain interface [polypeptide binding]; other site 1052585000181 L16 interface [polypeptide binding]; other site 1052585000182 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1052585000183 putative active site [active] 1052585000184 catalytic residue [active] 1052585000185 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 1052585000186 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1052585000187 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1052585000188 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052585000189 ATP binding site [chemical binding]; other site 1052585000190 putative Mg++ binding site [ion binding]; other site 1052585000191 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052585000192 nucleotide binding region [chemical binding]; other site 1052585000193 ATP-binding site [chemical binding]; other site 1052585000194 TRCF domain; Region: TRCF; cl04088 1052585000195 stage V sporulation protein T; Region: spore_V_T; TIGR02851 1052585000196 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1052585000197 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1052585000198 MatE; Region: MatE; cl10513 1052585000199 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 1052585000200 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 1052585000201 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 1052585000202 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052585000203 RNA binding surface [nucleotide binding]; other site 1052585000204 YabP family; Region: YabP; cl06766 1052585000205 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 1052585000206 Septum formation initiator; Region: DivIC; cl11433 1052585000207 hypothetical protein; Provisional; Region: PRK08582 1052585000208 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 1052585000209 RNA binding site [nucleotide binding]; other site 1052585000210 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1052585000211 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1052585000212 metal ion-dependent adhesion site (MIDAS); other site 1052585000213 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052585000214 active site 1052585000215 ATP binding site [chemical binding]; other site 1052585000216 substrate binding site [chemical binding]; other site 1052585000217 activation loop (A-loop); other site 1052585000218 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1052585000219 Ligand Binding Site [chemical binding]; other site 1052585000220 B3/4 domain; Region: B3_4; cl11458 1052585000221 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052585000222 active site 1052585000223 FtsH Extracellular; Region: FtsH_ext; pfam06480 1052585000224 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1052585000225 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585000226 Walker A motif; other site 1052585000227 ATP binding site [chemical binding]; other site 1052585000228 Walker B motif; other site 1052585000229 arginine finger; other site 1052585000230 Peptidase family M41; Region: Peptidase_M41; pfam01434 1052585000231 Type III pantothenate kinase; Region: Pan_kinase; cl09130 1052585000232 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1052585000233 domain crossover interface; other site 1052585000234 redox-dependent activation switch; other site 1052585000235 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1052585000236 PPIC-type PPIASE domain; Region: Rotamase; cl08278 1052585000237 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1052585000238 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1052585000239 dimer interface [polypeptide binding]; other site 1052585000240 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585000241 catalytic residue [active] 1052585000242 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1052585000243 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1052585000244 glutamine binding [chemical binding]; other site 1052585000245 catalytic triad [active] 1052585000246 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1052585000247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585000248 catalytic residue [active] 1052585000249 dihydropteroate synthase; Region: DHPS; TIGR01496 1052585000250 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1052585000251 substrate binding pocket [chemical binding]; other site 1052585000252 dimer interface [polypeptide binding]; other site 1052585000253 inhibitor binding site; inhibition site 1052585000254 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1052585000255 homooctamer interface [polypeptide binding]; other site 1052585000256 active site 1052585000257 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1052585000258 catalytic center binding site [active] 1052585000259 ATP binding site [chemical binding]; other site 1052585000260 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052585000261 non-specific DNA binding site [nucleotide binding]; other site 1052585000262 salt bridge; other site 1052585000263 sequence-specific DNA binding site [nucleotide binding]; other site 1052585000264 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1052585000265 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1052585000266 FMN binding site [chemical binding]; other site 1052585000267 active site 1052585000268 catalytic residues [active] 1052585000269 substrate binding site [chemical binding]; other site 1052585000270 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1052585000271 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1052585000272 dimer interface [polypeptide binding]; other site 1052585000273 putative anticodon binding site; other site 1052585000274 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1052585000275 motif 1; other site 1052585000276 active site 1052585000277 motif 2; other site 1052585000278 motif 3; other site 1052585000279 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 1052585000280 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1052585000281 UvrB/uvrC motif; Region: UVR; pfam02151 1052585000282 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 1052585000283 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1052585000284 ADP binding site [chemical binding]; other site 1052585000285 phosphagen binding site; other site 1052585000286 substrate specificity loop; other site 1052585000287 Clp protease ATP binding subunit; Region: clpC; CHL00095 1052585000288 Clp amino terminal domain; Region: Clp_N; pfam02861 1052585000289 Clp amino terminal domain; Region: Clp_N; pfam02861 1052585000290 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585000291 Walker A motif; other site 1052585000292 ATP binding site [chemical binding]; other site 1052585000293 Walker B motif; other site 1052585000294 arginine finger; other site 1052585000295 UvrB/uvrC motif; Region: UVR; pfam02151 1052585000296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585000297 Walker A motif; other site 1052585000298 ATP binding site [chemical binding]; other site 1052585000299 Walker B motif; other site 1052585000300 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1052585000301 DNA repair protein RadA; Provisional; Region: PRK11823 1052585000302 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1052585000303 Walker A motif/ATP binding site; other site 1052585000304 ATP binding site [chemical binding]; other site 1052585000305 Walker B motif; other site 1052585000306 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1052585000307 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1052585000308 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1052585000309 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1052585000310 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1052585000311 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1052585000312 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1052585000313 putative active site [active] 1052585000314 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1052585000315 substrate binding site; other site 1052585000316 dimer interface; other site 1052585000317 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1052585000318 homotrimer interaction site [polypeptide binding]; other site 1052585000319 zinc binding site [ion binding]; other site 1052585000320 CDP-binding sites; other site 1052585000321 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1052585000322 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1052585000323 active site 1052585000324 HIGH motif; other site 1052585000325 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1052585000326 active site 1052585000327 KMSKS motif; other site 1052585000328 serine O-acetyltransferase; Region: cysE; TIGR01172 1052585000329 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1052585000330 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1052585000331 trimer interface [polypeptide binding]; other site 1052585000332 active site 1052585000333 substrate binding site [chemical binding]; other site 1052585000334 CoA binding site [chemical binding]; other site 1052585000335 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1052585000336 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1052585000337 active site 1052585000338 HIGH motif; other site 1052585000339 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1052585000340 KMSKS motif; other site 1052585000341 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1052585000342 tRNA binding surface [nucleotide binding]; other site 1052585000343 anticodon binding site; other site 1052585000344 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1052585000345 active site 1052585000346 metal binding site [ion binding]; metal-binding site 1052585000347 dimerization interface [polypeptide binding]; other site 1052585000348 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1052585000349 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 1052585000350 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1052585000351 YacP-like NYN domain; Region: NYN_YacP; cl01491 1052585000352 RNA polymerase factor sigma-70; Validated; Region: PRK08295 1052585000353 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052585000354 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1052585000355 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 1052585000356 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1052585000357 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1052585000358 putative homodimer interface [polypeptide binding]; other site 1052585000359 KOW motif; Region: KOW; cl00354 1052585000360 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1052585000361 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1052585000362 23S rRNA interface [nucleotide binding]; other site 1052585000363 L7/L12 interface [polypeptide binding]; other site 1052585000364 putative thiostrepton binding site; other site 1052585000365 L25 interface [polypeptide binding]; other site 1052585000366 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1052585000367 mRNA/rRNA interface [nucleotide binding]; other site 1052585000368 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1052585000369 23S rRNA interface [nucleotide binding]; other site 1052585000370 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1052585000371 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1052585000372 core dimer interface [polypeptide binding]; other site 1052585000373 peripheral dimer interface [polypeptide binding]; other site 1052585000374 L10 interface [polypeptide binding]; other site 1052585000375 L11 interface [polypeptide binding]; other site 1052585000376 putative EF-Tu interaction site [polypeptide binding]; other site 1052585000377 putative EF-G interaction site [polypeptide binding]; other site 1052585000378 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585000379 S-adenosylmethionine binding site [chemical binding]; other site 1052585000380 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1052585000381 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 1052585000382 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1052585000383 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1052585000384 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1052585000385 RPB1 interaction site [polypeptide binding]; other site 1052585000386 RPB10 interaction site [polypeptide binding]; other site 1052585000387 RPB11 interaction site [polypeptide binding]; other site 1052585000388 RPB3 interaction site [polypeptide binding]; other site 1052585000389 RPB12 interaction site [polypeptide binding]; other site 1052585000390 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1052585000391 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1052585000392 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 1052585000393 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1052585000394 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1052585000395 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1052585000396 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1052585000397 G-loop; other site 1052585000398 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1052585000399 DNA binding site [nucleotide binding] 1052585000400 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1052585000401 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1052585000402 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1052585000403 S17 interaction site [polypeptide binding]; other site 1052585000404 S8 interaction site; other site 1052585000405 16S rRNA interaction site [nucleotide binding]; other site 1052585000406 streptomycin interaction site [chemical binding]; other site 1052585000407 23S rRNA interaction site [nucleotide binding]; other site 1052585000408 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1052585000409 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 1052585000410 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1052585000411 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1052585000412 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1052585000413 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1052585000414 elongation factor Tu; Reviewed; Region: PRK00049 1052585000415 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1052585000416 G1 box; other site 1052585000417 GEF interaction site [polypeptide binding]; other site 1052585000418 GTP/Mg2+ binding site [chemical binding]; other site 1052585000419 Switch I region; other site 1052585000420 G2 box; other site 1052585000421 G3 box; other site 1052585000422 Switch II region; other site 1052585000423 G4 box; other site 1052585000424 G5 box; other site 1052585000425 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1052585000426 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1052585000427 Antibiotic Binding Site [chemical binding]; other site 1052585000428 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052585000429 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052585000430 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 1052585000431 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 1052585000432 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1052585000433 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 1052585000434 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1052585000435 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1052585000436 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1052585000437 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1052585000438 putative translocon binding site; other site 1052585000439 protein-rRNA interface [nucleotide binding]; other site 1052585000440 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1052585000441 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1052585000442 G-X-X-G motif; other site 1052585000443 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1052585000444 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1052585000445 L27 interface [polypeptide binding]; other site 1052585000446 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1052585000447 23S rRNA interface [nucleotide binding]; other site 1052585000448 putative translocon interaction site; other site 1052585000449 signal recognition particle (SRP54) interaction site; other site 1052585000450 L23 interface [polypeptide binding]; other site 1052585000451 trigger factor interaction site; other site 1052585000452 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 1052585000453 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 1052585000454 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1052585000455 KOW motif; Region: KOW; cl00354 1052585000456 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1052585000457 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1052585000458 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1052585000459 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 1052585000460 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 1052585000461 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1052585000462 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1052585000463 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1052585000464 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1052585000465 5S rRNA interface [nucleotide binding]; other site 1052585000466 L27 interface [polypeptide binding]; other site 1052585000467 23S rRNA interface [nucleotide binding]; other site 1052585000468 L5 interface [polypeptide binding]; other site 1052585000469 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1052585000470 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1052585000471 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1052585000472 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1052585000473 23S rRNA binding site [nucleotide binding]; other site 1052585000474 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 1052585000475 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1052585000476 SecY translocase; Region: SecY; pfam00344 1052585000477 adenylate kinase; Reviewed; Region: adk; PRK00279 1052585000478 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1052585000479 AMP-binding site [chemical binding]; other site 1052585000480 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1052585000481 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1052585000482 active site 1052585000483 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 1052585000484 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 1052585000485 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 1052585000486 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1052585000487 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1052585000488 alphaNTD homodimer interface [polypeptide binding]; other site 1052585000489 alphaNTD - beta interaction site [polypeptide binding]; other site 1052585000490 alphaNTD - beta' interaction site [polypeptide binding]; other site 1052585000491 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 1052585000492 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 1052585000493 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1052585000494 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 1052585000495 Walker A/P-loop; other site 1052585000496 ATP binding site [chemical binding]; other site 1052585000497 Q-loop/lid; other site 1052585000498 ABC transporter signature motif; other site 1052585000499 Walker B; other site 1052585000500 D-loop; other site 1052585000501 H-loop/switch region; other site 1052585000502 Cobalt transport protein; Region: CbiQ; cl00463 1052585000503 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1052585000504 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 1052585000505 dimerization interface 3.5A [polypeptide binding]; other site 1052585000506 active site 1052585000507 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1052585000508 23S rRNA interface [nucleotide binding]; other site 1052585000509 L3 interface [polypeptide binding]; other site 1052585000510 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 1052585000511 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585000512 S-adenosylmethionine binding site [chemical binding]; other site 1052585000513 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 1052585000514 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1052585000515 active site 1052585000516 metal binding site [ion binding]; metal-binding site 1052585000517 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1052585000518 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 1052585000519 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 1052585000520 NodB motif; other site 1052585000521 putative active site [active] 1052585000522 putative catalytic site [active] 1052585000523 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1052585000524 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1052585000525 Int/Topo IB signature motif; other site 1052585000526 Domain of unknown function (DUF955); Region: DUF955; cl01076 1052585000527 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 1052585000528 GatB domain; Region: GatB_Yqey; cl11497 1052585000529 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052585000530 non-specific DNA binding site [nucleotide binding]; other site 1052585000531 salt bridge; other site 1052585000532 sequence-specific DNA binding site [nucleotide binding]; other site 1052585000533 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052585000534 non-specific DNA binding site [nucleotide binding]; other site 1052585000535 salt bridge; other site 1052585000536 sequence-specific DNA binding site [nucleotide binding]; other site 1052585000537 AAA domain; Region: AAA_23; pfam13476 1052585000538 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 1052585000539 RecT family; Region: RecT; cl04285 1052585000540 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052585000541 Loader and inhibitor of phage G40P; Region: Inhibitor_G39P; pfam11417 1052585000542 replicative DNA helicase; Region: DnaB; TIGR00665 1052585000543 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1052585000544 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1052585000545 Walker A motif; other site 1052585000546 ATP binding site [chemical binding]; other site 1052585000547 Walker B motif; other site 1052585000548 DNA binding loops [nucleotide binding] 1052585000549 Endodeoxyribonuclease RusA; Region: RusA; cl01885 1052585000550 pyruvate carboxylase subunit B; Validated; Region: PRK09282 1052585000551 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1052585000552 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1052585000553 active site 1052585000554 FMN binding site [chemical binding]; other site 1052585000555 substrate binding site [chemical binding]; other site 1052585000556 homotetramer interface [polypeptide binding]; other site 1052585000557 catalytic residue [active] 1052585000558 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052585000559 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1052585000560 active site 1052585000561 metal binding site [ion binding]; metal-binding site 1052585000562 ParB-like nuclease domain; Region: ParBc; cl02129 1052585000563 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1052585000564 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 1052585000565 cofactor binding site; other site 1052585000566 DNA binding site [nucleotide binding] 1052585000567 substrate interaction site [chemical binding]; other site 1052585000568 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 1052585000569 Uncharacterized conserved protein [Function unknown]; Region: COG5484 1052585000570 Phage terminase small subunit; Region: Phage_terminase; pfam10668 1052585000571 Phage terminase large subunit; Region: Terminase_3; cl12054 1052585000572 Terminase-like family; Region: Terminase_6; pfam03237 1052585000573 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1052585000574 phage portal protein, PBSX family; Region: portal_PBSX; TIGR01540 1052585000575 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1052585000576 Phage capsid family; Region: Phage_capsid; pfam05065 1052585000577 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 1052585000578 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 1052585000579 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1052585000580 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 1052585000581 Phage XkdN-like protein; Region: XkdN; pfam08890 1052585000582 Phage-related minor tail protein [Function unknown]; Region: COG5280 1052585000583 Phage-related protein [Function unknown]; Region: COG5412 1052585000584 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1052585000585 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1052585000586 catalytic residue [active] 1052585000587 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1052585000588 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1052585000589 putative peptidoglycan binding site; other site 1052585000590 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 1052585000591 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 1052585000592 Baseplate J-like protein; Region: Baseplate_J; cl01294 1052585000593 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 1052585000594 XkdW protein; Region: XkdW; pfam09636 1052585000595 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 1052585000596 Holin family; Region: Phage_holin_4; cl01989 1052585000597 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1052585000598 amidase catalytic site [active] 1052585000599 Zn binding residues [ion binding]; other site 1052585000600 substrate binding site [chemical binding]; other site 1052585000601 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1052585000602 putative peptidoglycan binding site; other site 1052585000603 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1052585000604 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1052585000605 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 1052585000606 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1052585000607 binding surface 1052585000608 TPR motif; other site 1052585000609 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052585000610 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1052585000611 YolD-like protein; Region: YolD; pfam08863 1052585000612 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1052585000613 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1052585000614 Int/Topo IB signature motif; other site 1052585000615 Domain of unknown function (DUF955); Region: DUF955; cl01076 1052585000616 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 1052585000617 GatB domain; Region: GatB_Yqey; cl11497 1052585000618 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052585000619 non-specific DNA binding site [nucleotide binding]; other site 1052585000620 salt bridge; other site 1052585000621 sequence-specific DNA binding site [nucleotide binding]; other site 1052585000622 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052585000623 non-specific DNA binding site [nucleotide binding]; other site 1052585000624 salt bridge; other site 1052585000625 sequence-specific DNA binding site [nucleotide binding]; other site 1052585000626 AAA domain; Region: AAA_23; pfam13476 1052585000627 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 1052585000628 RecT family; Region: RecT; cl04285 1052585000629 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052585000630 Loader and inhibitor of phage G40P; Region: Inhibitor_G39P; pfam11417 1052585000631 replicative DNA helicase; Region: DnaB; TIGR00665 1052585000632 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1052585000633 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1052585000634 Walker A motif; other site 1052585000635 ATP binding site [chemical binding]; other site 1052585000636 Walker B motif; other site 1052585000637 DNA binding loops [nucleotide binding] 1052585000638 Endodeoxyribonuclease RusA; Region: RusA; cl01885 1052585000639 pyruvate carboxylase subunit B; Validated; Region: PRK09282 1052585000640 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1052585000641 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1052585000642 active site 1052585000643 FMN binding site [chemical binding]; other site 1052585000644 substrate binding site [chemical binding]; other site 1052585000645 homotetramer interface [polypeptide binding]; other site 1052585000646 catalytic residue [active] 1052585000647 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052585000648 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1052585000649 active site 1052585000650 metal binding site [ion binding]; metal-binding site 1052585000651 ParB-like nuclease domain; Region: ParBc; cl02129 1052585000652 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1052585000653 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 1052585000654 cofactor binding site; other site 1052585000655 DNA binding site [nucleotide binding] 1052585000656 substrate interaction site [chemical binding]; other site 1052585000657 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 1052585000658 Uncharacterized conserved protein [Function unknown]; Region: COG5484 1052585000659 Phage terminase small subunit; Region: Phage_terminase; pfam10668 1052585000660 Phage terminase large subunit; Region: Terminase_3; cl12054 1052585000661 Terminase-like family; Region: Terminase_6; pfam03237 1052585000662 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1052585000663 phage portal protein, PBSX family; Region: portal_PBSX; TIGR01540 1052585000664 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1052585000665 Phage capsid family; Region: Phage_capsid; pfam05065 1052585000666 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 1052585000667 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 1052585000668 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1052585000669 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 1052585000670 Phage XkdN-like protein; Region: XkdN; pfam08890 1052585000671 Phage-related minor tail protein [Function unknown]; Region: COG5280 1052585000672 Phage-related protein [Function unknown]; Region: COG5412 1052585000673 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1052585000674 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1052585000675 catalytic residue [active] 1052585000676 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1052585000677 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1052585000678 putative peptidoglycan binding site; other site 1052585000679 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1052585000680 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 1052585000681 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 1052585000682 Baseplate J-like protein; Region: Baseplate_J; cl01294 1052585000683 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 1052585000684 XkdW protein; Region: XkdW; pfam09636 1052585000685 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 1052585000686 Holin family; Region: Phage_holin_4; cl01989 1052585000687 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1052585000688 amidase catalytic site [active] 1052585000689 Zn binding residues [ion binding]; other site 1052585000690 substrate binding site [chemical binding]; other site 1052585000691 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1052585000692 putative peptidoglycan binding site; other site 1052585000693 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1052585000694 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1052585000695 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 1052585000696 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1052585000697 binding surface 1052585000698 TPR motif; other site 1052585000699 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052585000700 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1052585000701 YolD-like protein; Region: YolD; pfam08863 1052585000702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585000703 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585000704 putative substrate translocation pore; other site 1052585000705 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1052585000706 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052585000707 inhibitor-cofactor binding pocket; inhibition site 1052585000708 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585000709 catalytic residue [active] 1052585000710 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1052585000711 active site 1052585000712 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1052585000713 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585000714 NAD(P) binding site [chemical binding]; other site 1052585000715 Sulfate transporter family; Region: Sulfate_transp; cl15842 1052585000716 high affinity sulphate transporter 1; Region: sulP; TIGR00815 1052585000717 Sulfate transporter family; Region: Sulfate_transp; cl15842 1052585000718 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1052585000719 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1052585000720 Membrane transport protein; Region: Mem_trans; cl09117 1052585000721 Membrane transport protein; Region: Mem_trans; cl09117 1052585000722 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052585000723 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1052585000724 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052585000725 dimer interface [polypeptide binding]; other site 1052585000726 putative PBP binding regions; other site 1052585000727 ABC-ATPase subunit interface; other site 1052585000728 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052585000729 ABC-ATPase subunit interface; other site 1052585000730 dimer interface [polypeptide binding]; other site 1052585000731 putative PBP binding regions; other site 1052585000732 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1052585000733 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1052585000734 putative ligand binding residues [chemical binding]; other site 1052585000735 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052585000736 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052585000737 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052585000738 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1052585000739 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1052585000740 putative ligand binding residues [chemical binding]; other site 1052585000741 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 1052585000742 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1052585000743 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1052585000744 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1052585000745 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052585000746 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1052585000747 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1052585000748 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052585000749 active site turn [active] 1052585000750 phosphorylation site [posttranslational modification] 1052585000751 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1052585000752 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1052585000753 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1052585000754 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1052585000755 putative active site [active] 1052585000756 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1052585000757 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1052585000758 putative active site [active] 1052585000759 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1052585000760 Protein of unknown function (DUF523); Region: DUF523; cl00733 1052585000761 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 1052585000762 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052585000763 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052585000764 DNA binding residues [nucleotide binding] 1052585000765 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1052585000766 Putative zinc-finger; Region: zf-HC2; cl15806 1052585000767 TIGR00159 family protein; Region: TIGR00159 1052585000768 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1052585000769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1052585000770 YbbR-like protein; Region: YbbR; pfam07949 1052585000771 YbbR-like protein; Region: YbbR; pfam07949 1052585000772 YbbR-like protein; Region: YbbR; pfam07949 1052585000773 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1052585000774 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1052585000775 active site 1052585000776 substrate binding site [chemical binding]; other site 1052585000777 metal binding site [ion binding]; metal-binding site 1052585000778 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1052585000779 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1052585000780 glutaminase active site [active] 1052585000781 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1052585000782 dimer interface [polypeptide binding]; other site 1052585000783 active site 1052585000784 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1052585000785 dimer interface [polypeptide binding]; other site 1052585000786 active site 1052585000787 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 1052585000788 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 1052585000789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 1052585000790 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1052585000791 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1052585000792 dimer interface [polypeptide binding]; other site 1052585000793 zinc binding site [ion binding]; other site 1052585000794 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 1052585000795 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052585000796 dimerization interface [polypeptide binding]; other site 1052585000797 putative DNA binding site [nucleotide binding]; other site 1052585000798 putative Zn2+ binding site [ion binding]; other site 1052585000799 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052585000800 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585000801 putative substrate translocation pore; other site 1052585000802 HEAT repeats; Region: HEAT_2; pfam13646 1052585000803 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052585000804 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1052585000805 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1052585000806 DNA binding residues [nucleotide binding] 1052585000807 drug binding residues [chemical binding]; other site 1052585000808 dimer interface [polypeptide binding]; other site 1052585000809 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1052585000810 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052585000811 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052585000812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585000813 active site 1052585000814 phosphorylation site [posttranslational modification] 1052585000815 intermolecular recognition site; other site 1052585000816 dimerization interface [polypeptide binding]; other site 1052585000817 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052585000818 DNA binding site [nucleotide binding] 1052585000819 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1052585000820 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1052585000821 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052585000822 dimer interface [polypeptide binding]; other site 1052585000823 phosphorylation site [posttranslational modification] 1052585000824 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585000825 ATP binding site [chemical binding]; other site 1052585000826 Mg2+ binding site [ion binding]; other site 1052585000827 G-X-G motif; other site 1052585000828 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1052585000829 active site 1052585000830 ATP binding site [chemical binding]; other site 1052585000831 substrate binding site [chemical binding]; other site 1052585000832 activation loop (A-loop); other site 1052585000833 putative transport protein YifK; Provisional; Region: PRK10746 1052585000834 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052585000835 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1052585000836 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1052585000837 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1052585000838 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1052585000839 PhoU domain; Region: PhoU; pfam01895 1052585000840 PhoU domain; Region: PhoU; pfam01895 1052585000841 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 1052585000842 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1052585000843 active site 1052585000844 catalytic site [active] 1052585000845 metal binding site [ion binding]; metal-binding site 1052585000846 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 1052585000847 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585000848 putative substrate translocation pore; other site 1052585000849 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585000850 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 1052585000851 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585000852 Helix-turn-helix domains; Region: HTH; cl00088 1052585000853 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1052585000854 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585000855 Coenzyme A binding pocket [chemical binding]; other site 1052585000856 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585000857 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585000858 putative substrate translocation pore; other site 1052585000859 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1052585000860 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1052585000861 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1052585000862 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1052585000863 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 1052585000864 active site 1052585000865 Cupin domain; Region: Cupin_2; cl09118 1052585000866 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052585000867 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052585000868 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052585000869 Phage lysis protein, holin; Region: Phage_holin; cl04675 1052585000870 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1052585000871 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1052585000872 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052585000873 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1052585000874 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1052585000875 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 1052585000876 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052585000877 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1052585000878 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 1052585000879 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 1052585000880 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1052585000881 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1052585000882 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1052585000883 active site residue [active] 1052585000884 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1052585000885 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1052585000886 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1052585000887 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1052585000888 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1052585000889 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052585000890 active site turn [active] 1052585000891 phosphorylation site [posttranslational modification] 1052585000892 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1052585000893 HPr interaction site; other site 1052585000894 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1052585000895 active site 1052585000896 phosphorylation site [posttranslational modification] 1052585000897 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1052585000898 active site 1052585000899 trimer interface [polypeptide binding]; other site 1052585000900 allosteric site; other site 1052585000901 active site lid [active] 1052585000902 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1052585000903 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1052585000904 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585000905 DNA-binding site [nucleotide binding]; DNA binding site 1052585000906 UTRA domain; Region: UTRA; cl01230 1052585000907 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1052585000908 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1052585000909 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1052585000910 homodimer interface [polypeptide binding]; other site 1052585000911 substrate-cofactor binding pocket; other site 1052585000912 catalytic residue [active] 1052585000913 S-methylmethionine transporter; Provisional; Region: PRK11387 1052585000914 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1052585000915 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1052585000916 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1052585000917 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1052585000918 Glutaminase; Region: Glutaminase; cl00907 1052585000919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585000920 Response regulator receiver domain; Region: Response_reg; pfam00072 1052585000921 active site 1052585000922 phosphorylation site [posttranslational modification] 1052585000923 intermolecular recognition site; other site 1052585000924 dimerization interface [polypeptide binding]; other site 1052585000925 YcbB domain; Region: YcbB; pfam08664 1052585000926 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 1052585000927 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1052585000928 putative active site [active] 1052585000929 catalytic residue [active] 1052585000930 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 1052585000931 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1052585000932 NAD(P) binding site [chemical binding]; other site 1052585000933 catalytic residues [active] 1052585000934 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585000935 D-galactonate transporter; Region: 2A0114; TIGR00893 1052585000936 putative substrate translocation pore; other site 1052585000937 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1052585000938 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1052585000939 active site 1052585000940 tetramer interface [polypeptide binding]; other site 1052585000941 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1052585000942 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585000943 DNA-binding site [nucleotide binding]; DNA binding site 1052585000944 FCD domain; Region: FCD; cl11656 1052585000945 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1052585000946 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1052585000947 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 1052585000948 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: MPH2'; cd05152 1052585000949 putative active site [active] 1052585000950 putative substrate binding site [chemical binding]; other site 1052585000951 ATP binding site [chemical binding]; other site 1052585000952 anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748 1052585000953 dodecamer interface 2 [polypeptide binding]; other site 1052585000954 dodecamer interface 1 [polypeptide binding]; other site 1052585000955 trimer interface [polypeptide binding]; other site 1052585000956 TRAP binding interface [polypeptide binding]; other site 1052585000957 Zn binding site [ion binding]; other site 1052585000958 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1052585000959 EamA-like transporter family; Region: EamA; cl01037 1052585000960 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052585000961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585000962 active site 1052585000963 phosphorylation site [posttranslational modification] 1052585000964 intermolecular recognition site; other site 1052585000965 dimerization interface [polypeptide binding]; other site 1052585000966 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052585000967 DNA binding site [nucleotide binding] 1052585000968 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1052585000969 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052585000970 dimer interface [polypeptide binding]; other site 1052585000971 phosphorylation site [posttranslational modification] 1052585000972 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585000973 ATP binding site [chemical binding]; other site 1052585000974 Mg2+ binding site [ion binding]; other site 1052585000975 G-X-G motif; other site 1052585000976 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052585000977 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 1052585000978 Walker A/P-loop; other site 1052585000979 ATP binding site [chemical binding]; other site 1052585000980 Q-loop/lid; other site 1052585000981 ABC transporter signature motif; other site 1052585000982 Walker B; other site 1052585000983 D-loop; other site 1052585000984 H-loop/switch region; other site 1052585000985 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1052585000986 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 1052585000987 reactive center loop; other site 1052585000988 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1052585000989 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1052585000990 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1052585000991 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1052585000992 putative active site [active] 1052585000993 putative metal binding site [ion binding]; other site 1052585000994 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1052585000995 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1052585000996 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 1052585000997 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1052585000998 putative substrate binding pocket [chemical binding]; other site 1052585000999 AC domain interface; other site 1052585001000 catalytic triad [active] 1052585001001 AB domain interface; other site 1052585001002 interchain disulfide; other site 1052585001003 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1052585001004 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1052585001005 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052585001006 catalytic residue [active] 1052585001007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585001008 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1052585001009 putative substrate translocation pore; other site 1052585001010 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585001011 Helix-turn-helix domains; Region: HTH; cl00088 1052585001012 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1052585001013 active site 1052585001014 homotetramer interface [polypeptide binding]; other site 1052585001015 homodimer interface [polypeptide binding]; other site 1052585001016 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052585001017 RDD family; Region: RDD; cl00746 1052585001018 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 1052585001019 helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225 1052585001020 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1052585001021 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585001022 ATP binding site [chemical binding]; other site 1052585001023 Mg2+ binding site [ion binding]; other site 1052585001024 G-X-G motif; other site 1052585001025 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1052585001026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585001027 active site 1052585001028 phosphorylation site [posttranslational modification] 1052585001029 intermolecular recognition site; other site 1052585001030 dimerization interface [polypeptide binding]; other site 1052585001031 LytTr DNA-binding domain; Region: LytTR; cl04498 1052585001032 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1052585001033 NatA is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled proton or K+ uptake. NatB possess six putative membrane spanning regions at its...; Region: ABC_NatA_sodium_exporter; cd03266 1052585001034 Walker A/P-loop; other site 1052585001035 ATP binding site [chemical binding]; other site 1052585001036 Q-loop/lid; other site 1052585001037 ABC transporter signature motif; other site 1052585001038 Walker B; other site 1052585001039 D-loop; other site 1052585001040 H-loop/switch region; other site 1052585001041 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1052585001042 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1052585001043 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1052585001044 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052585001045 active site 1052585001046 catalytic tetrad [active] 1052585001047 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1052585001048 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1052585001049 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1052585001050 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052585001051 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1052585001052 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1052585001053 NAD binding site [chemical binding]; other site 1052585001054 homodimer interface [polypeptide binding]; other site 1052585001055 active site 1052585001056 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1052585001057 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1052585001058 Ca binding site [ion binding]; other site 1052585001059 active site 1052585001060 catalytic site [active] 1052585001061 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1052585001062 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1052585001063 metal binding site [ion binding]; metal-binding site 1052585001064 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1052585001065 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 1052585001066 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1052585001067 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1052585001068 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1052585001069 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1052585001070 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1052585001071 putative metal binding site [ion binding]; other site 1052585001072 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1052585001073 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1052585001074 putative metal binding site [ion binding]; other site 1052585001075 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1052585001076 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1052585001077 putative metal binding site [ion binding]; other site 1052585001078 Integral membrane protein TerC family; Region: TerC; cl10468 1052585001079 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 1052585001080 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1052585001081 benzoate transport; Region: 2A0115; TIGR00895 1052585001082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585001083 putative substrate translocation pore; other site 1052585001084 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052585001085 dimerization interface [polypeptide binding]; other site 1052585001086 putative DNA binding site [nucleotide binding]; other site 1052585001087 putative Zn2+ binding site [ion binding]; other site 1052585001088 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 1052585001089 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1052585001090 Walker A/P-loop; other site 1052585001091 ATP binding site [chemical binding]; other site 1052585001092 Q-loop/lid; other site 1052585001093 ABC transporter signature motif; other site 1052585001094 Walker B; other site 1052585001095 D-loop; other site 1052585001096 H-loop/switch region; other site 1052585001097 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1052585001098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585001099 dimer interface [polypeptide binding]; other site 1052585001100 conserved gate region; other site 1052585001101 putative PBP binding loops; other site 1052585001102 ABC-ATPase subunit interface; other site 1052585001103 NMT1-like family; Region: NMT1_2; cl15260 1052585001104 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 1052585001105 amidohydrolase; Region: amidohydrolases; TIGR01891 1052585001106 metal binding site [ion binding]; metal-binding site 1052585001107 putative dimer interface [polypeptide binding]; other site 1052585001108 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 1052585001109 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1052585001110 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 1052585001111 active site 1052585001112 Ca binding site [ion binding]; other site 1052585001113 catalytic site [active] 1052585001114 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 1052585001115 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1052585001116 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1052585001117 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052585001118 NAD binding site [chemical binding]; other site 1052585001119 dimer interface [polypeptide binding]; other site 1052585001120 substrate binding site [chemical binding]; other site 1052585001121 glycolate transporter; Provisional; Region: PRK09695 1052585001122 L-lactate permease; Region: Lactate_perm; cl00701 1052585001123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585001124 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585001125 putative substrate translocation pore; other site 1052585001126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585001127 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585001128 Helix-turn-helix domains; Region: HTH; cl00088 1052585001129 LysE type translocator; Region: LysE; cl00565 1052585001130 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 1052585001131 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1052585001132 Spore germination protein; Region: Spore_permease; cl15802 1052585001133 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 1052585001134 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1052585001135 NAD+ synthetase; Region: nadE; TIGR00552 1052585001136 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1052585001137 homodimer interface [polypeptide binding]; other site 1052585001138 NAD binding pocket [chemical binding]; other site 1052585001139 ATP binding pocket [chemical binding]; other site 1052585001140 Mg binding site [ion binding]; other site 1052585001141 active-site loop [active] 1052585001142 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585001143 AAA domain; Region: AAA_18; pfam13238 1052585001144 shikimate kinase; Reviewed; Region: aroK; PRK00131 1052585001145 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1052585001146 ADP binding site [chemical binding]; other site 1052585001147 magnesium binding site [ion binding]; other site 1052585001148 putative shikimate binding site; other site 1052585001149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585001150 S-adenosylmethionine binding site [chemical binding]; other site 1052585001151 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052585001152 Helix-turn-helix domains; Region: HTH; cl00088 1052585001153 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052585001154 dimerization interface [polypeptide binding]; other site 1052585001155 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1052585001156 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 1052585001157 Proline dehydrogenase; Region: Pro_dh; cl03282 1052585001158 Sodium:solute symporter family; Region: SSF; cl00456 1052585001159 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1052585001160 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1052585001161 Helix-turn-helix domains; Region: HTH; cl00088 1052585001162 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 1052585001163 Predicted permeases [General function prediction only]; Region: COG0701 1052585001164 Predicted permease; Region: DUF318; pfam03773 1052585001165 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1052585001166 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052585001167 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 1052585001168 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1052585001169 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1052585001170 active site 1052585001171 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1052585001172 [2Fe-2S] cluster binding site [ion binding]; other site 1052585001173 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1052585001174 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052585001175 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1052585001176 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1052585001177 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1052585001178 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1052585001179 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1052585001180 [4Fe-4S] binding site [ion binding]; other site 1052585001181 molybdopterin cofactor binding site; other site 1052585001182 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1052585001183 molybdopterin cofactor binding site; other site 1052585001184 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1052585001185 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052585001186 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1052585001187 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1052585001188 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1052585001189 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1052585001190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585001191 putative substrate translocation pore; other site 1052585001192 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 1052585001193 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 1052585001194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585001195 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1052585001196 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052585001197 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1052585001198 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585001199 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 1052585001200 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1052585001201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585001202 dimer interface [polypeptide binding]; other site 1052585001203 conserved gate region; other site 1052585001204 putative PBP binding loops; other site 1052585001205 ABC-ATPase subunit interface; other site 1052585001206 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1052585001207 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1052585001208 substrate binding pocket [chemical binding]; other site 1052585001209 membrane-bound complex binding site; other site 1052585001210 hinge residues; other site 1052585001211 Alcohol dehydrogenase GroES-associated; Region: ADH_N_assoc; pfam13823 1052585001212 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585001213 RDD family; Region: RDD; cl00746 1052585001214 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 1052585001215 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585001216 Helix-turn-helix domains; Region: HTH; cl00088 1052585001217 hypothetical protein; Provisional; Region: PRK09272 1052585001218 Predicted ATPase [General function prediction only]; Region: COG3910 1052585001219 ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The...; Region: ABC_ATPase; cd00267 1052585001220 Walker A/P-loop; other site 1052585001221 ATP binding site [chemical binding]; other site 1052585001222 Q-loop/lid; other site 1052585001223 ABC transporter signature motif; other site 1052585001224 Walker B; other site 1052585001225 D-loop; other site 1052585001226 H-loop/switch region; other site 1052585001227 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1052585001228 Competence protein J (ComJ); Region: ComJ; pfam11033 1052585001229 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1052585001230 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1052585001231 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052585001232 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052585001233 dimer interface [polypeptide binding]; other site 1052585001234 putative CheW interface [polypeptide binding]; other site 1052585001235 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1052585001236 tetramer interface [polypeptide binding]; other site 1052585001237 Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane]; Region: GutQ; COG0794 1052585001238 active site 1052585001239 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1052585001240 active site 1052585001241 dimer interface [polypeptide binding]; other site 1052585001242 magnesium binding site [ion binding]; other site 1052585001243 Helix-turn-helix domains; Region: HTH; cl00088 1052585001244 peptide synthase; Provisional; Region: PRK12467 1052585001245 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585001246 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585001247 peptide synthase; Provisional; Region: PRK12467 1052585001248 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052585001249 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585001250 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585001251 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052585001252 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585001253 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585001254 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052585001255 peptide synthase; Provisional; Region: PRK12467 1052585001256 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585001257 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585001258 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585001259 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1052585001260 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1052585001261 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 1052585001262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585001263 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585001264 putative substrate translocation pore; other site 1052585001265 YcxB-like protein; Region: YcxB; pfam14317 1052585001266 EamA-like transporter family; Region: EamA; cl01037 1052585001267 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1052585001268 EamA-like transporter family; Region: EamA; cl01037 1052585001269 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1052585001270 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585001271 DNA-binding site [nucleotide binding]; DNA binding site 1052585001272 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052585001273 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585001274 homodimer interface [polypeptide binding]; other site 1052585001275 catalytic residue [active] 1052585001276 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1052585001277 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1052585001278 Predicted membrane protein [Function unknown]; Region: COG2364 1052585001279 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052585001280 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1052585001281 binding surface 1052585001282 TPR motif; other site 1052585001283 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052585001284 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1052585001285 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1052585001286 Walker A/P-loop; other site 1052585001287 ATP binding site [chemical binding]; other site 1052585001288 Q-loop/lid; other site 1052585001289 ABC transporter signature motif; other site 1052585001290 Walker B; other site 1052585001291 D-loop; other site 1052585001292 H-loop/switch region; other site 1052585001293 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1052585001294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585001295 dimer interface [polypeptide binding]; other site 1052585001296 conserved gate region; other site 1052585001297 putative PBP binding loops; other site 1052585001298 ABC-ATPase subunit interface; other site 1052585001299 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1052585001300 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1052585001301 substrate binding pocket [chemical binding]; other site 1052585001302 membrane-bound complex binding site; other site 1052585001303 hinge residues; other site 1052585001304 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052585001305 Helix-turn-helix domains; Region: HTH; cl00088 1052585001306 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052585001307 dimerization interface [polypeptide binding]; other site 1052585001308 polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases; Region: ubiX_pad; TIGR00421 1052585001309 Flavoprotein; Region: Flavoprotein; cl08021 1052585001310 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 1052585001311 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1052585001312 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1052585001313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585001314 putative substrate translocation pore; other site 1052585001315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 1052585001316 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1052585001317 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 1052585001318 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1052585001319 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 1052585001320 Spore germination protein; Region: Spore_permease; cl15802 1052585001321 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052585001322 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1052585001323 Walker A/P-loop; other site 1052585001324 ATP binding site [chemical binding]; other site 1052585001325 Q-loop/lid; other site 1052585001326 ABC transporter signature motif; other site 1052585001327 Walker B; other site 1052585001328 D-loop; other site 1052585001329 H-loop/switch region; other site 1052585001330 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1052585001331 FtsX-like permease family; Region: FtsX; cl15850 1052585001332 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052585001333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585001334 active site 1052585001335 phosphorylation site [posttranslational modification] 1052585001336 intermolecular recognition site; other site 1052585001337 dimerization interface [polypeptide binding]; other site 1052585001338 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052585001339 DNA binding site [nucleotide binding] 1052585001340 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052585001341 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052585001342 dimerization interface [polypeptide binding]; other site 1052585001343 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052585001344 dimer interface [polypeptide binding]; other site 1052585001345 phosphorylation site [posttranslational modification] 1052585001346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585001347 ATP binding site [chemical binding]; other site 1052585001348 Mg2+ binding site [ion binding]; other site 1052585001349 G-X-G motif; other site 1052585001350 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052585001351 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052585001352 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052585001353 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1052585001354 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 1052585001355 aspartate kinase; Reviewed; Region: PRK09034 1052585001356 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1052585001357 putative catalytic residues [active] 1052585001358 putative nucleotide binding site [chemical binding]; other site 1052585001359 putative aspartate binding site [chemical binding]; other site 1052585001360 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1052585001361 allosteric regulatory residue; other site 1052585001362 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1052585001363 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1052585001364 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052585001365 ABC-ATPase subunit interface; other site 1052585001366 dimer interface [polypeptide binding]; other site 1052585001367 putative PBP binding regions; other site 1052585001368 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052585001369 ABC-ATPase subunit interface; other site 1052585001370 dimer interface [polypeptide binding]; other site 1052585001371 putative PBP binding regions; other site 1052585001372 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1052585001373 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1052585001374 Walker A/P-loop; other site 1052585001375 ATP binding site [chemical binding]; other site 1052585001376 Q-loop/lid; other site 1052585001377 ABC transporter signature motif; other site 1052585001378 Walker B; other site 1052585001379 D-loop; other site 1052585001380 H-loop/switch region; other site 1052585001381 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1052585001382 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1052585001383 putative ligand binding residues [chemical binding]; other site 1052585001384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585001385 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585001386 putative substrate translocation pore; other site 1052585001387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585001388 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585001389 Helix-turn-helix domains; Region: HTH; cl00088 1052585001390 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1052585001391 dimer interface [polypeptide binding]; other site 1052585001392 FMN binding site [chemical binding]; other site 1052585001393 NADPH bind site [chemical binding]; other site 1052585001394 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1052585001395 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052585001396 dimerization interface [polypeptide binding]; other site 1052585001397 putative DNA binding site [nucleotide binding]; other site 1052585001398 putative Zn2+ binding site [ion binding]; other site 1052585001399 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1052585001400 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585001401 DNA-binding site [nucleotide binding]; DNA binding site 1052585001402 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052585001403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585001404 homodimer interface [polypeptide binding]; other site 1052585001405 catalytic residue [active] 1052585001406 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 1052585001407 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052585001408 inhibitor-cofactor binding pocket; inhibition site 1052585001409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585001410 catalytic residue [active] 1052585001411 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1052585001412 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1052585001413 tetramerization interface [polypeptide binding]; other site 1052585001414 NAD(P) binding site [chemical binding]; other site 1052585001415 catalytic residues [active] 1052585001416 Sugar transport protein; Region: Sugar_transport; pfam06800 1052585001417 glucose-1-dehydrogenase; Provisional; Region: PRK08936 1052585001418 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 1052585001419 NAD binding site [chemical binding]; other site 1052585001420 homodimer interface [polypeptide binding]; other site 1052585001421 active site 1052585001422 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1052585001423 Bacterial Ig-like domain; Region: Big_5; cl01012 1052585001424 Copper resistance protein D; Region: CopD; cl00563 1052585001425 FixH; Region: FixH; cl01254 1052585001426 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1052585001427 Helix-turn-helix domains; Region: HTH; cl00088 1052585001428 NosL; Region: NosL; cl01769 1052585001429 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1052585001430 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1052585001431 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1052585001432 active site 1052585001433 P-loop; other site 1052585001434 phosphorylation site [posttranslational modification] 1052585001435 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1052585001436 active site 1052585001437 phosphorylation site [posttranslational modification] 1052585001438 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1052585001439 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1052585001440 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1052585001441 tartrate dehydrogenase; Provisional; Region: PRK08194 1052585001442 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1052585001443 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1052585001444 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1052585001445 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585001446 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1052585001447 active site 1052585001448 motif I; other site 1052585001449 motif II; other site 1052585001450 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585001451 LamB/YcsF family; Region: LamB_YcsF; cl00664 1052585001452 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1052585001453 Protein of unknown function (DUF1445); Region: DUF1445; cl01790 1052585001454 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1052585001455 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1052585001456 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 1052585001457 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1052585001458 Helix-turn-helix domains; Region: HTH; cl00088 1052585001459 Bacterial transcriptional regulator; Region: IclR; pfam01614 1052585001460 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1052585001461 active site 1052585001462 catalytic triad [active] 1052585001463 oxyanion hole [active] 1052585001464 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 1052585001465 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1052585001466 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1052585001467 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1052585001468 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1052585001469 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052585001470 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052585001471 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052585001472 active site 1052585001473 catalytic tetrad [active] 1052585001474 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1052585001475 Helix-turn-helix domains; Region: HTH; cl00088 1052585001476 Helix-turn-helix domains; Region: HTH; cl00088 1052585001477 PRD domain; Region: PRD; cl15445 1052585001478 PRD domain; Region: PRD; cl15445 1052585001479 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1052585001480 P-loop; other site 1052585001481 active site 1052585001482 phosphorylation site [posttranslational modification] 1052585001483 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1052585001484 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585001485 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585001486 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585001487 S-adenosylmethionine binding site [chemical binding]; other site 1052585001488 short chain dehydrogenase; Provisional; Region: PRK06701 1052585001489 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1052585001490 NAD binding site [chemical binding]; other site 1052585001491 metal binding site [ion binding]; metal-binding site 1052585001492 active site 1052585001493 Cupin domain; Region: Cupin_2; cl09118 1052585001494 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052585001495 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052585001496 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1052585001497 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1052585001498 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 1052585001499 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 1052585001500 Helix-turn-helix domains; Region: HTH; cl00088 1052585001501 DNA topoisomerase III; Provisional; Region: PRK07726 1052585001502 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1052585001503 active site 1052585001504 putative interdomain interaction site [polypeptide binding]; other site 1052585001505 putative metal-binding site [ion binding]; other site 1052585001506 putative nucleotide binding site [chemical binding]; other site 1052585001507 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1052585001508 domain I; other site 1052585001509 DNA binding groove [nucleotide binding] 1052585001510 phosphate binding site [ion binding]; other site 1052585001511 domain II; other site 1052585001512 domain III; other site 1052585001513 nucleotide binding site [chemical binding]; other site 1052585001514 catalytic site [active] 1052585001515 domain IV; other site 1052585001516 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1052585001517 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1052585001518 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1052585001519 CCC1-related family of proteins; Region: CCC1_like; cl00278 1052585001520 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1052585001521 metal binding site [ion binding]; metal-binding site 1052585001522 active site 1052585001523 I-site; other site 1052585001524 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 1052585001525 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 1052585001526 NodB motif; other site 1052585001527 putative active site [active] 1052585001528 putative catalytic site [active] 1052585001529 putative Zn binding site [ion binding]; other site 1052585001530 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1052585001531 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1052585001532 DXD motif; other site 1052585001533 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1052585001534 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1052585001535 Amino acid permease; Region: AA_permease_2; pfam13520 1052585001536 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1052585001537 nudix motif; other site 1052585001538 pyruvate oxidase; Provisional; Region: PRK08611 1052585001539 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1052585001540 PYR/PP interface [polypeptide binding]; other site 1052585001541 tetramer interface [polypeptide binding]; other site 1052585001542 dimer interface [polypeptide binding]; other site 1052585001543 TPP binding site [chemical binding]; other site 1052585001544 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1052585001545 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1052585001546 TPP-binding site [chemical binding]; other site 1052585001547 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 1052585001548 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1052585001549 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1052585001550 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1052585001551 EcsC protein family; Region: EcsC; pfam12787 1052585001552 General stress protein [General function prediction only]; Region: GsiB; COG3729 1052585001553 Cupin domain; Region: Cupin_2; cl09118 1052585001554 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1052585001555 dimanganese center [ion binding]; other site 1052585001556 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1052585001557 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1052585001558 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1052585001559 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1052585001560 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585001561 ATP binding site [chemical binding]; other site 1052585001562 Mg2+ binding site [ion binding]; other site 1052585001563 G-X-G motif; other site 1052585001564 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1052585001565 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585001566 active site 1052585001567 phosphorylation site [posttranslational modification] 1052585001568 intermolecular recognition site; other site 1052585001569 dimerization interface [polypeptide binding]; other site 1052585001570 Helix-turn-helix domains; Region: HTH; cl00088 1052585001571 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1052585001572 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1052585001573 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1052585001574 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1052585001575 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1052585001576 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052585001577 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585001578 Walker A/P-loop; other site 1052585001579 ATP binding site [chemical binding]; other site 1052585001580 Q-loop/lid; other site 1052585001581 ABC transporter signature motif; other site 1052585001582 Walker B; other site 1052585001583 D-loop; other site 1052585001584 H-loop/switch region; other site 1052585001585 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1052585001586 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1052585001587 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1052585001588 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1052585001589 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1052585001590 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 1052585001591 Cation efflux family; Region: Cation_efflux; cl00316 1052585001592 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1052585001593 catalytic residues [active] 1052585001594 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1052585001595 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1052585001596 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1052585001597 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1052585001598 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 1052585001599 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1052585001600 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1052585001601 helicase 45; Provisional; Region: PTZ00424 1052585001602 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1052585001603 ATP binding site [chemical binding]; other site 1052585001604 Mg++ binding site [ion binding]; other site 1052585001605 motif III; other site 1052585001606 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052585001607 nucleotide binding region [chemical binding]; other site 1052585001608 ATP-binding site [chemical binding]; other site 1052585001609 Bacterial PH domain; Region: DUF304; cl01348 1052585001610 Predicted membrane protein [Function unknown]; Region: COG3428 1052585001611 Bacterial PH domain; Region: DUF304; cl01348 1052585001612 Bacterial PH domain; Region: DUF304; cl01348 1052585001613 Bacterial PH domain; Region: DUF304; cl01348 1052585001614 Rhomboid family; Region: Rhomboid; cl11446 1052585001615 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1052585001616 alanine racemase; Region: alr; TIGR00492 1052585001617 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1052585001618 active site 1052585001619 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1052585001620 dimer interface [polypeptide binding]; other site 1052585001621 substrate binding site [chemical binding]; other site 1052585001622 catalytic residues [active] 1052585001623 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1052585001624 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 1052585001625 PemK-like protein; Region: PemK; cl00995 1052585001626 Rsbr N terminal; Region: Rsbr_N; pfam08678 1052585001627 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1052585001628 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1052585001629 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1052585001630 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585001631 ATP binding site [chemical binding]; other site 1052585001632 Mg2+ binding site [ion binding]; other site 1052585001633 G-X-G motif; other site 1052585001634 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1052585001635 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1052585001636 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1052585001637 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1052585001638 anti sigma factor interaction site; other site 1052585001639 regulatory phosphorylation site [posttranslational modification]; other site 1052585001640 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1052585001641 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585001642 ATP binding site [chemical binding]; other site 1052585001643 Mg2+ binding site [ion binding]; other site 1052585001644 G-X-G motif; other site 1052585001645 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 1052585001646 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052585001647 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1052585001648 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052585001649 DNA binding residues [nucleotide binding] 1052585001650 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 1052585001651 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1052585001652 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1052585001653 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1052585001654 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 1052585001655 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1052585001656 RNA binding site [nucleotide binding]; other site 1052585001657 SprT homologues; Region: SprT; cl01182 1052585001658 hypothetical protein; Provisional; Region: PRK04351 1052585001659 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052585001660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585001661 putative substrate translocation pore; other site 1052585001662 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1052585001663 classical (c) SDRs; Region: SDR_c; cd05233 1052585001664 NAD(P) binding site [chemical binding]; other site 1052585001665 active site 1052585001666 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1052585001667 dimerization domain swap beta strand [polypeptide binding]; other site 1052585001668 regulatory protein interface [polypeptide binding]; other site 1052585001669 regulatory phosphorylation site [posttranslational modification]; other site 1052585001670 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1052585001671 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052585001672 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1052585001673 Helix-turn-helix domains; Region: HTH; cl00088 1052585001674 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1052585001675 Spore germination protein; Region: Spore_permease; cl15802 1052585001676 putative transporter; Provisional; Region: PRK11021 1052585001677 Helix-turn-helix domains; Region: HTH; cl00088 1052585001678 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585001679 Helix-turn-helix domains; Region: HTH; cl00088 1052585001680 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1052585001681 classical (c) SDRs; Region: SDR_c; cd05233 1052585001682 NAD(P) binding site [chemical binding]; other site 1052585001683 active site 1052585001684 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1052585001685 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1052585001686 putative NAD(P) binding site [chemical binding]; other site 1052585001687 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1052585001688 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1052585001689 Helix-turn-helix domains; Region: HTH; cl00088 1052585001690 Helix-turn-helix domains; Region: HTH; cl00088 1052585001691 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052585001692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585001693 putative substrate translocation pore; other site 1052585001694 N-acetylneuraminate lyase; Region: nanA; TIGR00683 1052585001695 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1052585001696 inhibitor site; inhibition site 1052585001697 active site 1052585001698 dimer interface [polypeptide binding]; other site 1052585001699 catalytic residue [active] 1052585001700 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1052585001701 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585001702 putative substrate translocation pore; other site 1052585001703 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1052585001704 Helix-turn-helix domains; Region: HTH; cl00088 1052585001705 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052585001706 dimerization interface [polypeptide binding]; other site 1052585001707 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1052585001708 MOSC domain; Region: MOSC; pfam03473 1052585001709 3-alpha domain; Region: 3-alpha; pfam03475 1052585001710 LysE type translocator; Region: LysE; cl00565 1052585001711 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 1052585001712 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1052585001713 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1052585001714 putative di-iron ligands [ion binding]; other site 1052585001715 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1052585001716 DNA-binding site [nucleotide binding]; DNA binding site 1052585001717 RNA-binding motif; other site 1052585001718 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1052585001719 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1052585001720 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585001721 DNA-binding site [nucleotide binding]; DNA binding site 1052585001722 FCD domain; Region: FCD; cl11656 1052585001723 cyanate transporter; Region: CynX; TIGR00896 1052585001724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585001725 putative substrate translocation pore; other site 1052585001726 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052585001727 non-specific DNA binding site [nucleotide binding]; other site 1052585001728 salt bridge; other site 1052585001729 sequence-specific DNA binding site [nucleotide binding]; other site 1052585001730 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052585001731 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052585001732 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1052585001733 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1052585001734 Protein of unknown function (DUF419); Region: DUF419; cl15265 1052585001735 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1052585001736 CAAX protease self-immunity; Region: Abi; cl00558 1052585001737 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1052585001738 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 1052585001739 NADP binding site [chemical binding]; other site 1052585001740 substrate binding site [chemical binding]; other site 1052585001741 active site 1052585001742 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1052585001743 dimerization domain swap beta strand [polypeptide binding]; other site 1052585001744 regulatory protein interface [polypeptide binding]; other site 1052585001745 regulatory phosphorylation site [posttranslational modification]; other site 1052585001746 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1052585001747 Helix-turn-helix domains; Region: HTH; cl00088 1052585001748 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052585001749 Helix-turn-helix domains; Region: HTH; cl00088 1052585001750 EamA-like transporter family; Region: EamA; cl01037 1052585001751 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1052585001752 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1052585001753 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585001754 DNA-binding site [nucleotide binding]; DNA binding site 1052585001755 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052585001756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585001757 homodimer interface [polypeptide binding]; other site 1052585001758 catalytic residue [active] 1052585001759 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1052585001760 putative active site [active] 1052585001761 putative catalytic site [active] 1052585001762 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052585001763 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052585001764 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1052585001765 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052585001766 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052585001767 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 1052585001768 Helix-turn-helix domains; Region: HTH; cl00088 1052585001769 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1052585001770 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052585001771 dimerization interface [polypeptide binding]; other site 1052585001772 putative DNA binding site [nucleotide binding]; other site 1052585001773 putative Zn2+ binding site [ion binding]; other site 1052585001774 arsenical pump membrane protein; Provisional; Region: PRK15445 1052585001775 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1052585001776 transmembrane helices; other site 1052585001777 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1052585001778 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1052585001779 active site 1052585001780 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052585001781 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1052585001782 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1052585001783 NodB motif; other site 1052585001784 active site 1052585001785 catalytic site [active] 1052585001786 Zn binding site [ion binding]; other site 1052585001787 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 1052585001788 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1052585001789 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052585001790 dimerization interface [polypeptide binding]; other site 1052585001791 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052585001792 dimer interface [polypeptide binding]; other site 1052585001793 phosphorylation site [posttranslational modification] 1052585001794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585001795 ATP binding site [chemical binding]; other site 1052585001796 Mg2+ binding site [ion binding]; other site 1052585001797 G-X-G motif; other site 1052585001798 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052585001799 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585001800 active site 1052585001801 phosphorylation site [posttranslational modification] 1052585001802 intermolecular recognition site; other site 1052585001803 dimerization interface [polypeptide binding]; other site 1052585001804 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052585001805 DNA binding site [nucleotide binding] 1052585001806 EamA-like transporter family; Region: EamA; cl01037 1052585001807 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1052585001808 EamA-like transporter family; Region: EamA; cl01037 1052585001809 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1052585001810 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585001811 DNA-binding site [nucleotide binding]; DNA binding site 1052585001812 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052585001813 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585001814 homodimer interface [polypeptide binding]; other site 1052585001815 catalytic residue [active] 1052585001816 Flavin Reductases; Region: FlaRed; cl00801 1052585001817 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052585001818 dimerization interface [polypeptide binding]; other site 1052585001819 putative Zn2+ binding site [ion binding]; other site 1052585001820 putative DNA binding site [nucleotide binding]; other site 1052585001821 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1052585001822 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1052585001823 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052585001824 Histidine kinase; Region: HisKA_3; pfam07730 1052585001825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585001826 ATP binding site [chemical binding]; other site 1052585001827 Mg2+ binding site [ion binding]; other site 1052585001828 G-X-G motif; other site 1052585001829 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052585001830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585001831 active site 1052585001832 phosphorylation site [posttranslational modification] 1052585001833 intermolecular recognition site; other site 1052585001834 dimerization interface [polypeptide binding]; other site 1052585001835 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052585001836 DNA binding residues [nucleotide binding] 1052585001837 dimerization interface [polypeptide binding]; other site 1052585001838 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1052585001839 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Validated; Region: PRK06698 1052585001840 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Validated; Region: PRK06698 1052585001841 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1052585001842 Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers [General function prediction only]; Region: COG5152 1052585001843 Protein of unknown function (DUF554); Region: DUF554; cl00784 1052585001844 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1052585001845 DNA binding residues [nucleotide binding] 1052585001846 drug binding residues [chemical binding]; other site 1052585001847 dimer interface [polypeptide binding]; other site 1052585001848 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1052585001849 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1052585001850 Cation efflux family; Region: Cation_efflux; cl00316 1052585001851 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1052585001852 dimer interface [polypeptide binding]; other site 1052585001853 FMN binding site [chemical binding]; other site 1052585001854 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1052585001855 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052585001856 Zn binding site [ion binding]; other site 1052585001857 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1052585001858 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052585001859 Zn binding site [ion binding]; other site 1052585001860 DoxX; Region: DoxX; cl00976 1052585001861 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1052585001862 catalytic residues [active] 1052585001863 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1052585001864 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1052585001865 putative dimer interface [polypeptide binding]; other site 1052585001866 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1052585001867 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585001868 Helix-turn-helix domains; Region: HTH; cl00088 1052585001869 DoxX; Region: DoxX; cl00976 1052585001870 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585001871 Coenzyme A binding pocket [chemical binding]; other site 1052585001872 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052585001873 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585001874 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1052585001875 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052585001876 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052585001877 DNA binding site [nucleotide binding] 1052585001878 domain linker motif; other site 1052585001879 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1052585001880 dimerization interface [polypeptide binding]; other site 1052585001881 ligand binding site [chemical binding]; other site 1052585001882 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1052585001883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585001884 putative substrate translocation pore; other site 1052585001885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585001886 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1052585001887 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1052585001888 AP (apurinic/apyrimidinic) site pocket; other site 1052585001889 Metal-binding active site; metal-binding site 1052585001890 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585001891 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585001892 putative substrate translocation pore; other site 1052585001893 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585001894 Helix-turn-helix domains; Region: HTH; cl00088 1052585001895 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1052585001896 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1052585001897 ABC transporter; Region: ABC_tran_2; pfam12848 1052585001898 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1052585001899 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1052585001900 Spore germination protein; Region: Spore_permease; cl15802 1052585001901 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1052585001902 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585001903 Helix-turn-helix domains; Region: HTH; cl00088 1052585001904 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1052585001905 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1052585001906 dimer interface [polypeptide binding]; other site 1052585001907 FMN binding site [chemical binding]; other site 1052585001908 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585001909 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052585001910 putative DNA binding site [nucleotide binding]; other site 1052585001911 putative Zn2+ binding site [ion binding]; other site 1052585001912 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1052585001913 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052585001914 non-specific DNA binding site [nucleotide binding]; other site 1052585001915 salt bridge; other site 1052585001916 sequence-specific DNA binding site [nucleotide binding]; other site 1052585001917 Cupin domain; Region: Cupin_2; cl09118 1052585001918 AzlC protein; Region: AzlC; cl00570 1052585001919 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1052585001920 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1052585001921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585001922 putative substrate translocation pore; other site 1052585001923 Helix-turn-helix domains; Region: HTH; cl00088 1052585001924 putative transposase OrfB; Reviewed; Region: PHA02517 1052585001925 HTH-like domain; Region: HTH_21; pfam13276 1052585001926 Integrase core domain; Region: rve; cl01316 1052585001927 Integrase core domain; Region: rve_3; cl15866 1052585001928 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 1052585001929 FCD domain; Region: FCD; cl11656 1052585001930 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1052585001931 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1052585001932 putative peptidoglycan binding site; other site 1052585001933 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1052585001934 putative peptidoglycan binding site; other site 1052585001935 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1052585001936 active site 1052585001937 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1052585001938 homodimer interface [polypeptide binding]; other site 1052585001939 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1052585001940 active site 1052585001941 TDP-binding site; other site 1052585001942 acceptor substrate-binding pocket; other site 1052585001943 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1052585001944 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1052585001945 dimer interface [polypeptide binding]; other site 1052585001946 Alkaline phosphatase homologues; Region: alkPPc; smart00098 1052585001947 active site 1052585001948 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 1052585001949 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052585001950 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1052585001951 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1052585001952 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1052585001953 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1052585001954 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052585001955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585001956 putative substrate translocation pore; other site 1052585001957 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1052585001958 active site 1052585001959 P-loop; other site 1052585001960 phosphorylation site [posttranslational modification] 1052585001961 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1052585001962 active site 1052585001963 methionine cluster; other site 1052585001964 phosphorylation site [posttranslational modification] 1052585001965 metal binding site [ion binding]; metal-binding site 1052585001966 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1052585001967 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1052585001968 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1052585001969 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1052585001970 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585001971 DNA-binding site [nucleotide binding]; DNA binding site 1052585001972 UTRA domain; Region: UTRA; cl01230 1052585001973 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1052585001974 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1052585001975 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1052585001976 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 1052585001977 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 1052585001978 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1052585001979 dimanganese center [ion binding]; other site 1052585001980 thiamine-monophosphate kinase; Region: thiL; TIGR01379 1052585001981 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1052585001982 ATP binding site [chemical binding]; other site 1052585001983 dimerization interface [polypeptide binding]; other site 1052585001984 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 1052585001985 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 1052585001986 Glycoprotease family; Region: Peptidase_M22; pfam00814 1052585001987 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1052585001988 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585001989 Coenzyme A binding pocket [chemical binding]; other site 1052585001990 UGMP family protein; Validated; Region: PRK09604 1052585001991 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 1052585001992 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1052585001993 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1052585001994 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1052585001995 ABC transporter; Region: ABC_tran_2; pfam12848 1052585001996 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1052585001997 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1052585001998 trimer interface [polypeptide binding]; other site 1052585001999 dimer interface [polypeptide binding]; other site 1052585002000 putative active site [active] 1052585002001 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1052585002002 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1052585002003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585002004 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1052585002005 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 1052585002006 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 1052585002007 CAAX protease self-immunity; Region: Abi; cl00558 1052585002008 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1052585002009 oligomerisation interface [polypeptide binding]; other site 1052585002010 mobile loop; other site 1052585002011 roof hairpin; other site 1052585002012 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1052585002013 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1052585002014 ring oligomerisation interface [polypeptide binding]; other site 1052585002015 ATP/Mg binding site [chemical binding]; other site 1052585002016 stacking interactions; other site 1052585002017 hinge regions; other site 1052585002018 NB-ARC domain; Region: NB-ARC; pfam00931 1052585002019 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1052585002020 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585002021 binding surface 1052585002022 TPR motif; other site 1052585002023 TPR repeat; Region: TPR_11; pfam13414 1052585002024 L-idonate 5-dehydrogenase; Region: PLN02702 1052585002025 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1052585002026 inhibitor binding site; inhibition site 1052585002027 catalytic Zn binding site [ion binding]; other site 1052585002028 structural Zn binding site [ion binding]; other site 1052585002029 NADP binding site [chemical binding]; other site 1052585002030 tetramer interface [polypeptide binding]; other site 1052585002031 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1052585002032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585002033 putative substrate translocation pore; other site 1052585002034 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1052585002035 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1052585002036 putative substrate binding site [chemical binding]; other site 1052585002037 putative ATP binding site [chemical binding]; other site 1052585002038 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1052585002039 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1052585002040 Repair protein; Region: Repair_PSII; cl01535 1052585002041 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 1052585002042 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1052585002043 Ion channel; Region: Ion_trans_2; cl11596 1052585002044 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585002045 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1052585002046 putative substrate translocation pore; other site 1052585002047 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585002048 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1052585002049 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1052585002050 putative NAD(P) binding site [chemical binding]; other site 1052585002051 catalytic Zn binding site [ion binding]; other site 1052585002052 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 1052585002053 Cold-inducible protein YdjO; Region: YdjO; pfam14169 1052585002054 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052585002055 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052585002056 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 1052585002057 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 1052585002058 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1052585002059 Cation efflux family; Region: Cation_efflux; cl00316 1052585002060 MoxR-like ATPases [General function prediction only]; Region: COG0714 1052585002061 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585002062 Walker A motif; other site 1052585002063 ATP binding site [chemical binding]; other site 1052585002064 Walker B motif; other site 1052585002065 arginine finger; other site 1052585002066 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1052585002067 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1052585002068 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1052585002069 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 1052585002070 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1052585002071 GMP synthase; Reviewed; Region: guaA; PRK00074 1052585002072 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1052585002073 AMP/PPi binding site [chemical binding]; other site 1052585002074 candidate oxyanion hole; other site 1052585002075 catalytic triad [active] 1052585002076 potential glutamine specificity residues [chemical binding]; other site 1052585002077 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1052585002078 ATP Binding subdomain [chemical binding]; other site 1052585002079 Ligand Binding sites [chemical binding]; other site 1052585002080 Dimerization subdomain; other site 1052585002081 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1052585002082 hypothetical protein; Provisional; Region: PRK04164 1052585002083 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 1052585002084 NETI protein; Region: NETI; pfam14044 1052585002085 AIR carboxylase; Region: AIRC; cl00310 1052585002086 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1052585002087 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585002088 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1052585002089 adenylosuccinate lyase; Provisional; Region: PRK07492 1052585002090 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1052585002091 tetramer interface [polypeptide binding]; other site 1052585002092 active site 1052585002093 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1052585002094 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1052585002095 ATP binding site [chemical binding]; other site 1052585002096 active site 1052585002097 substrate binding site [chemical binding]; other site 1052585002098 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 1052585002099 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1052585002100 putative active site [active] 1052585002101 catalytic triad [active] 1052585002102 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1052585002103 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1052585002104 dimerization interface [polypeptide binding]; other site 1052585002105 ATP binding site [chemical binding]; other site 1052585002106 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1052585002107 dimerization interface [polypeptide binding]; other site 1052585002108 ATP binding site [chemical binding]; other site 1052585002109 amidophosphoribosyltransferase; Provisional; Region: PRK07631 1052585002110 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1052585002111 active site 1052585002112 tetramer interface [polypeptide binding]; other site 1052585002113 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052585002114 active site 1052585002115 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1052585002116 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1052585002117 dimerization interface [polypeptide binding]; other site 1052585002118 putative ATP binding site [chemical binding]; other site 1052585002119 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1052585002120 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1052585002121 active site 1052585002122 substrate binding site [chemical binding]; other site 1052585002123 cosubstrate binding site; other site 1052585002124 catalytic site [active] 1052585002125 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1052585002126 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1052585002127 purine monophosphate binding site [chemical binding]; other site 1052585002128 dimer interface [polypeptide binding]; other site 1052585002129 putative catalytic residues [active] 1052585002130 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1052585002131 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1052585002132 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1052585002133 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1052585002134 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1052585002135 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1052585002136 Helix-turn-helix domains; Region: HTH; cl00088 1052585002137 putative transporter; Provisional; Region: PRK11021 1052585002138 Spore germination protein; Region: Spore_permease; cl15802 1052585002139 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1052585002140 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1052585002141 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1052585002142 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1052585002143 active site 1052585002144 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1052585002145 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 1052585002146 Helix-turn-helix domains; Region: HTH; cl00088 1052585002147 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 1052585002148 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1052585002149 active site 1052585002150 FMN binding site [chemical binding]; other site 1052585002151 substrate binding site [chemical binding]; other site 1052585002152 3Fe-4S cluster binding site [ion binding]; other site 1052585002153 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1052585002154 substrate binding site [chemical binding]; other site 1052585002155 putative active site [active] 1052585002156 dimer interface [polypeptide binding]; other site 1052585002157 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1052585002158 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585002159 Family description; Region: UvrD_C_2; cl15862 1052585002160 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1052585002161 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1052585002162 nucleotide binding pocket [chemical binding]; other site 1052585002163 K-X-D-G motif; other site 1052585002164 catalytic site [active] 1052585002165 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1052585002166 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1052585002167 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1052585002168 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1052585002169 Dimer interface [polypeptide binding]; other site 1052585002170 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 1052585002171 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052585002172 active site 1052585002173 ATP binding site [chemical binding]; other site 1052585002174 substrate binding site [chemical binding]; other site 1052585002175 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1052585002176 MgtC family; Region: MgtC; pfam02308 1052585002177 Sodium:solute symporter family; Region: SSF; cl00456 1052585002178 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1052585002179 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 1052585002180 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1052585002181 Amidase; Region: Amidase; cl11426 1052585002182 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1052585002183 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1052585002184 GatB domain; Region: GatB_Yqey; cl11497 1052585002185 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585002186 Helix-turn-helix domains; Region: HTH; cl00088 1052585002187 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1052585002188 Protein export membrane protein; Region: SecD_SecF; cl14618 1052585002189 Protein export membrane protein; Region: SecD_SecF; cl14618 1052585002190 putative lipid kinase; Reviewed; Region: PRK13337 1052585002191 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1052585002192 TRAM domain; Region: TRAM; cl01282 1052585002193 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1052585002194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585002195 S-adenosylmethionine binding site [chemical binding]; other site 1052585002196 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 1052585002197 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 1052585002198 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1052585002199 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 1052585002200 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1052585002201 Uncharacterized conserved protein [Function unknown]; Region: COG3586 1052585002202 Transcriptional regulator; Region: Transcrip_reg; cl00361 1052585002203 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585002204 Helix-turn-helix domains; Region: HTH; cl00088 1052585002205 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1052585002206 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585002207 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1052585002208 NAD(P) binding site [chemical binding]; other site 1052585002209 active site 1052585002210 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 1052585002211 CotJB protein; Region: CotJB; pfam12652 1052585002212 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1052585002213 dimanganese center [ion binding]; other site 1052585002214 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052585002215 Protein of unknown function, DUF624; Region: DUF624; cl02369 1052585002216 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1052585002217 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1052585002218 Histidine kinase; Region: His_kinase; pfam06580 1052585002219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585002220 ATP binding site [chemical binding]; other site 1052585002221 Mg2+ binding site [ion binding]; other site 1052585002222 G-X-G motif; other site 1052585002223 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 1052585002224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585002225 active site 1052585002226 phosphorylation site [posttranslational modification] 1052585002227 intermolecular recognition site; other site 1052585002228 dimerization interface [polypeptide binding]; other site 1052585002229 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052585002230 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052585002231 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1052585002232 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052585002233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585002234 dimer interface [polypeptide binding]; other site 1052585002235 conserved gate region; other site 1052585002236 putative PBP binding loops; other site 1052585002237 ABC-ATPase subunit interface; other site 1052585002238 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052585002239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585002240 dimer interface [polypeptide binding]; other site 1052585002241 conserved gate region; other site 1052585002242 putative PBP binding loops; other site 1052585002243 ABC-ATPase subunit interface; other site 1052585002244 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1052585002245 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052585002246 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052585002247 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1052585002248 active site 1052585002249 catalytic triad [active] 1052585002250 Domain of unknown function (DUF1961); Region: DUF1961; pfam09224 1052585002251 Protein of unknown function, DUF624; Region: DUF624; cl02369 1052585002252 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1052585002253 metal binding site [ion binding]; metal-binding site 1052585002254 active site 1052585002255 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1052585002256 metal binding site [ion binding]; metal-binding site 1052585002257 active site 1052585002258 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1052585002259 active site 1052585002260 catalytic triad [active] 1052585002261 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1052585002262 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 1052585002263 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1052585002264 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1052585002265 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1052585002266 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052585002267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585002268 putative PBP binding loops; other site 1052585002269 dimer interface [polypeptide binding]; other site 1052585002270 ABC-ATPase subunit interface; other site 1052585002271 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052585002272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585002273 dimer interface [polypeptide binding]; other site 1052585002274 conserved gate region; other site 1052585002275 putative PBP binding loops; other site 1052585002276 ABC-ATPase subunit interface; other site 1052585002277 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1052585002278 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585002279 NAD(P) binding site [chemical binding]; other site 1052585002280 LDH/MDH dimer interface [polypeptide binding]; other site 1052585002281 substrate binding site [chemical binding]; other site 1052585002282 Protein of unknown function (DUF421); Region: DUF421; cl00990 1052585002283 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1052585002284 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052585002285 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1052585002286 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1052585002287 Uncharacterized small protein (DUF2292); Region: DUF2292; cl02371 1052585002288 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1052585002289 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1052585002290 EamA-like transporter family; Region: EamA; cl01037 1052585002291 EamA-like transporter family; Region: EamA; cl01037 1052585002292 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585002293 Helix-turn-helix domains; Region: HTH; cl00088 1052585002294 hypothetical protein; Provisional; Region: PRK06847 1052585002295 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585002296 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 1052585002297 Mrr N-terminal domain; Region: Mrr_N; pfam14338 1052585002298 Restriction endonuclease; Region: Mrr_cat; cl00516 1052585002299 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 1052585002300 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 1052585002301 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1052585002302 Cytochrome P450; Region: p450; pfam00067 1052585002303 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1052585002304 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1052585002305 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1052585002306 FAD binding pocket [chemical binding]; other site 1052585002307 FAD binding motif [chemical binding]; other site 1052585002308 catalytic residues [active] 1052585002309 NAD binding pocket [chemical binding]; other site 1052585002310 phosphate binding motif [ion binding]; other site 1052585002311 beta-alpha-beta structure motif; other site 1052585002312 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1052585002313 Sulfatase; Region: Sulfatase; cl10460 1052585002314 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1052585002315 substrate binding site; other site 1052585002316 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585002317 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 1052585002318 NAD(P) binding site [chemical binding]; other site 1052585002319 active site 1052585002320 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1052585002321 Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; cl05288 1052585002322 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585002323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585002324 putative substrate translocation pore; other site 1052585002325 amino acid transporter; Region: 2A0306; TIGR00909 1052585002326 Spore germination protein; Region: Spore_permease; cl15802 1052585002327 Spore germination protein; Region: Spore_permease; cl15802 1052585002328 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1052585002329 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1052585002330 NAD(P) binding site [chemical binding]; other site 1052585002331 catalytic residues [active] 1052585002332 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052585002333 dimer interface [polypeptide binding]; other site 1052585002334 putative CheW interface [polypeptide binding]; other site 1052585002335 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1052585002336 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585002337 Walker A/P-loop; other site 1052585002338 ATP binding site [chemical binding]; other site 1052585002339 Q-loop/lid; other site 1052585002340 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1052585002341 ABC transporter signature motif; other site 1052585002342 Walker B; other site 1052585002343 D-loop; other site 1052585002344 ABC transporter; Region: ABC_tran_2; pfam12848 1052585002345 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1052585002346 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 1052585002347 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 1052585002348 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1052585002349 DNA binding residues [nucleotide binding] 1052585002350 putative dimer interface [polypeptide binding]; other site 1052585002351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585002352 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585002353 putative substrate translocation pore; other site 1052585002354 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1052585002355 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585002356 Coenzyme A binding pocket [chemical binding]; other site 1052585002357 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1052585002358 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585002359 Walker A/P-loop; other site 1052585002360 ATP binding site [chemical binding]; other site 1052585002361 Q-loop/lid; other site 1052585002362 ABC transporter signature motif; other site 1052585002363 Walker B; other site 1052585002364 D-loop; other site 1052585002365 H-loop/switch region; other site 1052585002366 ABC transporter; Region: ABC_tran_2; pfam12848 1052585002367 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1052585002368 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1052585002369 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1052585002370 ATP binding site [chemical binding]; other site 1052585002371 Mg++ binding site [ion binding]; other site 1052585002372 motif III; other site 1052585002373 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052585002374 nucleotide binding region [chemical binding]; other site 1052585002375 ATP-binding site [chemical binding]; other site 1052585002376 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1052585002377 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052585002378 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1052585002379 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1052585002380 NAD(P) binding site [chemical binding]; other site 1052585002381 substrate binding site [chemical binding]; other site 1052585002382 dimer interface [polypeptide binding]; other site 1052585002383 H+ Antiporter protein; Region: 2A0121; TIGR00900 1052585002384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585002385 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 1052585002386 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1052585002387 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1052585002388 Walker A/P-loop; other site 1052585002389 ATP binding site [chemical binding]; other site 1052585002390 Q-loop/lid; other site 1052585002391 ABC transporter signature motif; other site 1052585002392 Walker B; other site 1052585002393 D-loop; other site 1052585002394 H-loop/switch region; other site 1052585002395 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052585002396 ABC-ATPase subunit interface; other site 1052585002397 dimer interface [polypeptide binding]; other site 1052585002398 putative PBP binding regions; other site 1052585002399 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052585002400 ABC-ATPase subunit interface; other site 1052585002401 dimer interface [polypeptide binding]; other site 1052585002402 putative PBP binding regions; other site 1052585002403 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1052585002404 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1052585002405 siderophore binding site; other site 1052585002406 Protein of unknown function (DUF3212); Region: DUF3212; pfam11486 1052585002407 Heat induced stress protein YflT; Region: YflT; pfam11181 1052585002408 Pectate lyase; Region: Pec_lyase_C; cl01593 1052585002409 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1052585002410 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1052585002411 transmembrane helices; other site 1052585002412 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1052585002413 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585002414 ATP binding site [chemical binding]; other site 1052585002415 Mg2+ binding site [ion binding]; other site 1052585002416 G-X-G motif; other site 1052585002417 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1052585002418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585002419 active site 1052585002420 phosphorylation site [posttranslational modification] 1052585002421 intermolecular recognition site; other site 1052585002422 dimerization interface [polypeptide binding]; other site 1052585002423 Transcriptional regulator; Region: CitT; pfam12431 1052585002424 Helix-turn-helix domains; Region: HTH; cl00088 1052585002425 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1052585002426 NMT1-like family; Region: NMT1_2; cl15260 1052585002427 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 1052585002428 Citrate transporter; Region: CitMHS; pfam03600 1052585002429 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052585002430 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 1052585002431 active site 1052585002432 dimer interface [polypeptide binding]; other site 1052585002433 Acylphosphatase; Region: Acylphosphatase; cl00551 1052585002434 MOSC domain; Region: MOSC; pfam03473 1052585002435 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 1052585002436 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1052585002437 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1052585002438 active site 1052585002439 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1052585002440 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1052585002441 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052585002442 active site turn [active] 1052585002443 phosphorylation site [posttranslational modification] 1052585002444 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1052585002445 Sulfatase; Region: Sulfatase; cl10460 1052585002446 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 1052585002447 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1052585002448 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1052585002449 Spore germination protein; Region: Spore_permease; cl15802 1052585002450 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1052585002451 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1052585002452 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052585002453 active site turn [active] 1052585002454 phosphorylation site [posttranslational modification] 1052585002455 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1052585002456 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1052585002457 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1052585002458 active site 1052585002459 catalytic site [active] 1052585002460 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1052585002461 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585002462 DNA-binding site [nucleotide binding]; DNA binding site 1052585002463 UTRA domain; Region: UTRA; cl01230 1052585002464 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1052585002465 dimer interface [polypeptide binding]; other site 1052585002466 FMN binding site [chemical binding]; other site 1052585002467 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 1052585002468 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1052585002469 active site 1052585002470 metal binding site [ion binding]; metal-binding site 1052585002471 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1052585002472 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 1052585002473 active site 1052585002474 metal binding site [ion binding]; metal-binding site 1052585002475 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1052585002476 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1052585002477 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1052585002478 proposed catalytic triad [active] 1052585002479 conserved cys residue [active] 1052585002480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585002481 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585002482 putative substrate translocation pore; other site 1052585002483 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 1052585002484 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1052585002485 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1052585002486 active site 1052585002487 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1052585002488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585002489 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585002490 putative substrate translocation pore; other site 1052585002491 calcium/proton exchanger (cax); Region: cax; TIGR00378 1052585002492 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1052585002493 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1052585002494 YfkD-like protein; Region: YfkD; pfam14167 1052585002495 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1052585002496 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1052585002497 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052585002498 FeS/SAM binding site; other site 1052585002499 YfkB-like domain; Region: YfkB; pfam08756 1052585002500 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 1052585002501 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1052585002502 NodB motif; other site 1052585002503 active site 1052585002504 catalytic site [active] 1052585002505 Cd binding site [ion binding]; other site 1052585002506 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1052585002507 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585002508 magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383 1052585002509 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 1052585002510 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1052585002511 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1052585002512 minor groove reading motif; other site 1052585002513 helix-hairpin-helix signature motif; other site 1052585002514 substrate binding pocket [chemical binding]; other site 1052585002515 active site 1052585002516 TRAM domain; Region: TRAM; cl01282 1052585002517 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1052585002518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585002519 S-adenosylmethionine binding site [chemical binding]; other site 1052585002520 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1052585002521 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1052585002522 FMN binding site [chemical binding]; other site 1052585002523 active site 1052585002524 catalytic residues [active] 1052585002525 substrate binding site [chemical binding]; other site 1052585002526 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1052585002527 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052585002528 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1052585002529 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1052585002530 tetramer interface [polypeptide binding]; other site 1052585002531 TPP-binding site [chemical binding]; other site 1052585002532 heterodimer interface [polypeptide binding]; other site 1052585002533 phosphorylation loop region [posttranslational modification] 1052585002534 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1052585002535 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1052585002536 alpha subunit interface [polypeptide binding]; other site 1052585002537 TPP binding site [chemical binding]; other site 1052585002538 heterodimer interface [polypeptide binding]; other site 1052585002539 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1052585002540 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1052585002541 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1052585002542 E3 interaction surface; other site 1052585002543 lipoyl attachment site [posttranslational modification]; other site 1052585002544 e3 binding domain; Region: E3_binding; pfam02817 1052585002545 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 1052585002546 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 1052585002547 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052585002548 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1052585002549 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1052585002550 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585002551 Walker A motif; other site 1052585002552 ATP binding site [chemical binding]; other site 1052585002553 Walker B motif; other site 1052585002554 arginine finger; other site 1052585002555 Helix-turn-helix domains; Region: HTH; cl00088 1052585002556 Small acid-soluble spore protein H family; Region: SspH; cl06949 1052585002557 Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 1052585002558 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1052585002559 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1052585002560 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 1052585002561 NAD binding site [chemical binding]; other site 1052585002562 sugar binding site [chemical binding]; other site 1052585002563 divalent metal binding site [ion binding]; other site 1052585002564 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052585002565 dimer interface [polypeptide binding]; other site 1052585002566 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1052585002567 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1052585002568 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1052585002569 putative active site [active] 1052585002570 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1052585002571 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1052585002572 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052585002573 active site turn [active] 1052585002574 phosphorylation site [posttranslational modification] 1052585002575 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052585002576 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1052585002577 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585002578 Walker A/P-loop; other site 1052585002579 ATP binding site [chemical binding]; other site 1052585002580 Q-loop/lid; other site 1052585002581 ABC transporter signature motif; other site 1052585002582 Walker B; other site 1052585002583 D-loop; other site 1052585002584 H-loop/switch region; other site 1052585002585 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052585002586 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1052585002587 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 1052585002588 Walker A/P-loop; other site 1052585002589 ATP binding site [chemical binding]; other site 1052585002590 Q-loop/lid; other site 1052585002591 ABC transporter signature motif; other site 1052585002592 Walker B; other site 1052585002593 D-loop; other site 1052585002594 H-loop/switch region; other site 1052585002595 DoxX; Region: DoxX; cl00976 1052585002596 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1052585002597 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1052585002598 putative metal binding site [ion binding]; other site 1052585002599 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1052585002600 active site 1052585002601 metal binding site [ion binding]; metal-binding site 1052585002602 Cupin domain; Region: Cupin_2; cl09118 1052585002603 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052585002604 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052585002605 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052585002606 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1052585002607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585002608 putative substrate translocation pore; other site 1052585002609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585002610 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1052585002611 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1052585002612 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585002613 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1052585002614 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052585002615 Histidine kinase; Region: HisKA_3; pfam07730 1052585002616 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585002617 ATP binding site [chemical binding]; other site 1052585002618 Mg2+ binding site [ion binding]; other site 1052585002619 G-X-G motif; other site 1052585002620 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052585002621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585002622 active site 1052585002623 phosphorylation site [posttranslational modification] 1052585002624 intermolecular recognition site; other site 1052585002625 dimerization interface [polypeptide binding]; other site 1052585002626 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052585002627 DNA binding residues [nucleotide binding] 1052585002628 dimerization interface [polypeptide binding]; other site 1052585002629 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585002630 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1052585002631 Walker A/P-loop; other site 1052585002632 ATP binding site [chemical binding]; other site 1052585002633 Q-loop/lid; other site 1052585002634 ABC transporter signature motif; other site 1052585002635 Walker B; other site 1052585002636 D-loop; other site 1052585002637 H-loop/switch region; other site 1052585002638 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1052585002639 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1052585002640 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1052585002641 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1052585002642 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1052585002643 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052585002644 Helix-turn-helix domains; Region: HTH; cl00088 1052585002645 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1052585002646 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052585002647 OpgC protein; Region: OpgC_C; cl00792 1052585002648 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1052585002649 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1052585002650 DinB superfamily; Region: DinB_2; pfam12867 1052585002651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585002652 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585002653 putative substrate translocation pore; other site 1052585002654 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585002655 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585002656 Helix-turn-helix domains; Region: HTH; cl00088 1052585002657 Predicted integral membrane protein [Function unknown]; Region: COG0392 1052585002658 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 1052585002659 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1052585002660 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 1052585002661 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1052585002662 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1052585002663 siderophore binding site; other site 1052585002664 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052585002665 ABC-ATPase subunit interface; other site 1052585002666 dimer interface [polypeptide binding]; other site 1052585002667 putative PBP binding regions; other site 1052585002668 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1052585002669 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052585002670 ABC-ATPase subunit interface; other site 1052585002671 dimer interface [polypeptide binding]; other site 1052585002672 putative PBP binding regions; other site 1052585002673 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 1052585002674 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 1052585002675 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1052585002676 putative FMN binding site [chemical binding]; other site 1052585002677 YfhD-like protein; Region: YfhD; pfam14151 1052585002678 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1052585002679 TIGR01777 family protein; Region: yfcH 1052585002680 putative NAD(P) binding site [chemical binding]; other site 1052585002681 putative active site [active] 1052585002682 RecX family; Region: RecX; cl00936 1052585002683 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1052585002684 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052585002685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585002686 putative substrate translocation pore; other site 1052585002687 Small acid-soluble spore protein K family; Region: SspK; cl11509 1052585002688 WVELL protein; Region: WVELL; pfam14043 1052585002689 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 1052585002690 Bacterial SH3 domain; Region: SH3_3; cl02551 1052585002691 SdpI/YhfL protein family; Region: SdpI; pfam13630 1052585002692 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052585002693 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052585002694 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1052585002695 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1052585002696 Ligand binding site; other site 1052585002697 Putative Catalytic site; other site 1052585002698 DXD motif; other site 1052585002699 Predicted membrane protein [Function unknown]; Region: COG4485 1052585002700 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 1052585002701 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 1052585002702 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1052585002703 minor groove reading motif; other site 1052585002704 helix-hairpin-helix signature motif; other site 1052585002705 substrate binding pocket [chemical binding]; other site 1052585002706 active site 1052585002707 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1052585002708 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1052585002709 DNA binding and oxoG recognition site [nucleotide binding] 1052585002710 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1052585002711 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 1052585002712 putative NAD(P) binding site [chemical binding]; other site 1052585002713 active site 1052585002714 YgaB-like protein; Region: YgaB; pfam14182 1052585002715 Protein of unknown function (DUF402); Region: DUF402; cl00979 1052585002716 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052585002717 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1052585002718 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 1052585002719 Walker A/P-loop; other site 1052585002720 ATP binding site [chemical binding]; other site 1052585002721 Q-loop/lid; other site 1052585002722 ABC transporter signature motif; other site 1052585002723 Walker B; other site 1052585002724 D-loop; other site 1052585002725 H-loop/switch region; other site 1052585002726 Predicted membrane protein [Function unknown]; Region: COG4129 1052585002727 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 1052585002728 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1052585002729 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052585002730 inhibitor-cofactor binding pocket; inhibition site 1052585002731 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585002732 catalytic residue [active] 1052585002733 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1052585002734 catalytic triad [active] 1052585002735 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1052585002736 metal binding site 2 [ion binding]; metal-binding site 1052585002737 putative DNA binding helix; other site 1052585002738 metal binding site 1 [ion binding]; metal-binding site 1052585002739 dimer interface [polypeptide binding]; other site 1052585002740 structural Zn2+ binding site [ion binding]; other site 1052585002741 Protein of unknown function (DUF2614); Region: DUF2614; cl07936 1052585002742 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 1052585002743 SpoOM protein; Region: Spo0M; pfam07070 1052585002744 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1052585002745 active site pocket [active] 1052585002746 oxyanion hole [active] 1052585002747 catalytic triad [active] 1052585002748 active site nucleophile [active] 1052585002749 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1052585002750 ThiC-associated domain; Region: ThiC-associated; pfam13667 1052585002751 ThiC family; Region: ThiC; cl08031 1052585002752 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1052585002753 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1052585002754 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1052585002755 tetramer interface [polypeptide binding]; other site 1052585002756 heme binding pocket [chemical binding]; other site 1052585002757 NADPH binding site [chemical binding]; other site 1052585002758 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1052585002759 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 1052585002760 Walker A/P-loop; other site 1052585002761 ATP binding site [chemical binding]; other site 1052585002762 Q-loop/lid; other site 1052585002763 ABC transporter signature motif; other site 1052585002764 Walker B; other site 1052585002765 D-loop; other site 1052585002766 H-loop/switch region; other site 1052585002767 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1052585002768 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1052585002769 substrate binding pocket [chemical binding]; other site 1052585002770 membrane-bound complex binding site; other site 1052585002771 hinge residues; other site 1052585002772 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1052585002773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585002774 dimer interface [polypeptide binding]; other site 1052585002775 conserved gate region; other site 1052585002776 putative PBP binding loops; other site 1052585002777 ABC-ATPase subunit interface; other site 1052585002778 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1052585002779 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1052585002780 active site 1052585002781 dimer interface [polypeptide binding]; other site 1052585002782 non-prolyl cis peptide bond; other site 1052585002783 insertion regions; other site 1052585002784 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 1052585002785 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052585002786 non-specific DNA binding site [nucleotide binding]; other site 1052585002787 salt bridge; other site 1052585002788 sequence-specific DNA binding site [nucleotide binding]; other site 1052585002789 B3/4 domain; Region: B3_4; cl11458 1052585002790 iron-sulfur cluster binding protein, putative; Region: TIGR00276 1052585002791 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1052585002792 HEAT repeats; Region: HEAT_2; pfam13646 1052585002793 NlpC/P60 family; Region: NLPC_P60; cl11438 1052585002794 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1052585002795 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 1052585002796 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 1052585002797 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1052585002798 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1052585002799 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 1052585002800 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1052585002801 Uncharacterized conserved protein [Function unknown]; Region: COG2718 1052585002802 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1052585002803 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585002804 Helix-turn-helix domains; Region: HTH; cl00088 1052585002805 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1052585002806 carboxyltransferase (CT) interaction site; other site 1052585002807 biotinylation site [posttranslational modification]; other site 1052585002808 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1052585002809 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1052585002810 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585002811 putative substrate translocation pore; other site 1052585002812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585002813 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1052585002814 Predicted transcriptional regulators [Transcription]; Region: COG1725 1052585002815 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585002816 DNA-binding site [nucleotide binding]; DNA binding site 1052585002817 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1052585002818 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1052585002819 Walker A/P-loop; other site 1052585002820 ATP binding site [chemical binding]; other site 1052585002821 Q-loop/lid; other site 1052585002822 ABC transporter signature motif; other site 1052585002823 Walker B; other site 1052585002824 D-loop; other site 1052585002825 H-loop/switch region; other site 1052585002826 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052585002827 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 1052585002828 Walker A/P-loop; other site 1052585002829 ATP binding site [chemical binding]; other site 1052585002830 Q-loop/lid; other site 1052585002831 ABC transporter signature motif; other site 1052585002832 Walker B; other site 1052585002833 D-loop; other site 1052585002834 H-loop/switch region; other site 1052585002835 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1052585002836 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1052585002837 DNA-binding site [nucleotide binding]; DNA binding site 1052585002838 RNA-binding motif; other site 1052585002839 NMT1-like family; Region: NMT1_2; cl15260 1052585002840 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 1052585002841 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1052585002842 metal binding site [ion binding]; metal-binding site 1052585002843 active site 1052585002844 I-site; other site 1052585002845 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1052585002846 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1052585002847 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1052585002848 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1052585002849 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1052585002850 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG4085 1052585002851 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1052585002852 generic binding surface II; other site 1052585002853 generic binding surface I; other site 1052585002854 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1052585002855 generic binding surface II; other site 1052585002856 generic binding surface I; other site 1052585002857 Staphylococcal nuclease homologues; Region: SNc; smart00318 1052585002858 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1052585002859 Catalytic site; other site 1052585002860 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1052585002861 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1052585002862 putative active site [active] 1052585002863 putative metal binding site [ion binding]; other site 1052585002864 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1052585002865 Gram positive anchor; Region: Gram_pos_anchor; cl15427 1052585002866 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 1052585002867 active site 1052585002868 catalytic site [active] 1052585002869 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1052585002870 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1052585002871 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 1052585002872 active site 1052585002873 FOG: CBS domain [General function prediction only]; Region: COG0517 1052585002874 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1052585002875 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1052585002876 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585002877 motif II; other site 1052585002878 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585002879 Coenzyme A binding pocket [chemical binding]; other site 1052585002880 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1052585002881 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 1052585002882 putative active site [active] 1052585002883 catalytic triad [active] 1052585002884 putative dimer interface [polypeptide binding]; other site 1052585002885 Membrane transport protein; Region: Mem_trans; cl09117 1052585002886 aminotransferase; Validated; Region: PRK07678 1052585002887 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052585002888 inhibitor-cofactor binding pocket; inhibition site 1052585002889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585002890 catalytic residue [active] 1052585002891 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 1052585002892 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1052585002893 amphipathic channel; other site 1052585002894 Asn-Pro-Ala signature motifs; other site 1052585002895 glycerol kinase; Provisional; Region: glpK; PRK00047 1052585002896 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1052585002897 N- and C-terminal domain interface [polypeptide binding]; other site 1052585002898 active site 1052585002899 MgATP binding site [chemical binding]; other site 1052585002900 catalytic site [active] 1052585002901 metal binding site [ion binding]; metal-binding site 1052585002902 glycerol binding site [chemical binding]; other site 1052585002903 homotetramer interface [polypeptide binding]; other site 1052585002904 homodimer interface [polypeptide binding]; other site 1052585002905 FBP binding site [chemical binding]; other site 1052585002906 protein IIAGlc interface [polypeptide binding]; other site 1052585002907 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1052585002908 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1052585002909 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1052585002910 active site 1052585002911 substrate binding site [chemical binding]; other site 1052585002912 metal binding site [ion binding]; metal-binding site 1052585002913 GAF domain; Region: GAF_2; pfam13185 1052585002914 GAF domain; Region: GAF; cl15785 1052585002915 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1052585002916 Histidine kinase; Region: HisKA_3; pfam07730 1052585002917 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585002918 ATP binding site [chemical binding]; other site 1052585002919 Mg2+ binding site [ion binding]; other site 1052585002920 G-X-G motif; other site 1052585002921 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052585002922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585002923 active site 1052585002924 phosphorylation site [posttranslational modification] 1052585002925 intermolecular recognition site; other site 1052585002926 dimerization interface [polypeptide binding]; other site 1052585002927 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052585002928 DNA binding residues [nucleotide binding] 1052585002929 dimerization interface [polypeptide binding]; other site 1052585002930 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1052585002931 YhdB-like protein; Region: YhdB; pfam14148 1052585002932 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1052585002933 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1052585002934 putative peptidoglycan binding site; other site 1052585002935 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1052585002936 putative peptidoglycan binding site; other site 1052585002937 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1052585002938 putative peptidoglycan binding site; other site 1052585002939 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1052585002940 putative peptidoglycan binding site; other site 1052585002941 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1052585002942 putative peptidoglycan binding site; other site 1052585002943 NlpC/P60 family; Region: NLPC_P60; cl11438 1052585002944 Helix-turn-helix domains; Region: HTH; cl00088 1052585002945 Rrf2 family protein; Region: rrf2_super; TIGR00738 1052585002946 Conserved TM helix; Region: TM_helix; pfam05552 1052585002947 Conserved TM helix; Region: TM_helix; pfam05552 1052585002948 Conserved TM helix; Region: TM_helix; pfam05552 1052585002949 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1052585002950 dimer interface [polypeptide binding]; other site 1052585002951 Alkaline phosphatase homologues; Region: alkPPc; smart00098 1052585002952 active site 1052585002953 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1052585002954 putative peptidoglycan binding site; other site 1052585002955 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1052585002956 putative peptidoglycan binding site; other site 1052585002957 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1052585002958 putative peptidoglycan binding site; other site 1052585002959 NlpC/P60 family; Region: NLPC_P60; cl11438 1052585002960 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052585002961 Helix-turn-helix domains; Region: HTH; cl00088 1052585002962 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052585002963 dimerization interface [polypeptide binding]; other site 1052585002964 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1052585002965 dimer interface [polypeptide binding]; other site 1052585002966 Citrate synthase; Region: Citrate_synt; pfam00285 1052585002967 active site 1052585002968 citrylCoA binding site [chemical binding]; other site 1052585002969 oxalacetate/citrate binding site [chemical binding]; other site 1052585002970 coenzyme A binding site [chemical binding]; other site 1052585002971 catalytic triad [active] 1052585002972 short chain dehydrogenase; Provisional; Region: PRK06701 1052585002973 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1052585002974 NAD binding site [chemical binding]; other site 1052585002975 metal binding site [ion binding]; metal-binding site 1052585002976 active site 1052585002977 amino acid transporter; Region: 2A0306; TIGR00909 1052585002978 Spore germination protein; Region: Spore_permease; cl15802 1052585002979 Spore germination protein; Region: Spore_permease; cl15802 1052585002980 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 1052585002981 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1052585002982 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585002983 DNA-binding site [nucleotide binding]; DNA binding site 1052585002984 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052585002985 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585002986 homodimer interface [polypeptide binding]; other site 1052585002987 catalytic residue [active] 1052585002988 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1052585002989 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585002990 Coenzyme A binding pocket [chemical binding]; other site 1052585002991 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 1052585002992 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 1052585002993 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 1052585002994 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052585002995 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052585002996 DNA binding residues [nucleotide binding] 1052585002997 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1052585002998 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052585002999 active site 1052585003000 catalytic tetrad [active] 1052585003001 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1052585003002 putative acyl-acceptor binding pocket; other site 1052585003003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585003004 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1052585003005 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1052585003006 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585003007 NAD(P) binding site [chemical binding]; other site 1052585003008 active site 1052585003009 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1052585003010 Domain of unknown function DUF21; Region: DUF21; pfam01595 1052585003011 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1052585003012 Transporter associated domain; Region: CorC_HlyC; cl08393 1052585003013 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 1052585003014 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1052585003015 DNA binding residues [nucleotide binding] 1052585003016 putative dimer interface [polypeptide binding]; other site 1052585003017 aspartate aminotransferase; Provisional; Region: PRK06836 1052585003018 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052585003019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585003020 homodimer interface [polypeptide binding]; other site 1052585003021 catalytic residue [active] 1052585003022 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1052585003023 Domain of unknown function DUF21; Region: DUF21; pfam01595 1052585003024 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1052585003025 Transporter associated domain; Region: CorC_HlyC; cl08393 1052585003026 CrcB-like protein; Region: CRCB; cl09114 1052585003027 CrcB-like protein; Region: CRCB; cl09114 1052585003028 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1052585003029 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1052585003030 active site 1052585003031 catalytic site [active] 1052585003032 metal binding site [ion binding]; metal-binding site 1052585003033 dimer interface [polypeptide binding]; other site 1052585003034 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1052585003035 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1052585003036 NAD-dependent deacetylase; Provisional; Region: PRK00481 1052585003037 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1052585003038 NAD+ binding site [chemical binding]; other site 1052585003039 substrate binding site [chemical binding]; other site 1052585003040 Zn binding site [ion binding]; other site 1052585003041 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1052585003042 NodB motif; other site 1052585003043 active site 1052585003044 catalytic site [active] 1052585003045 Zn binding site [ion binding]; other site 1052585003046 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1052585003047 homodimer interface [polypeptide binding]; other site 1052585003048 substrate-cofactor binding pocket; other site 1052585003049 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585003050 catalytic residue [active] 1052585003051 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1052585003052 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1052585003053 Ligand Binding Site [chemical binding]; other site 1052585003054 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1052585003055 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1052585003056 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585003057 Walker A/P-loop; other site 1052585003058 ATP binding site [chemical binding]; other site 1052585003059 Q-loop/lid; other site 1052585003060 ABC transporter signature motif; other site 1052585003061 Walker B; other site 1052585003062 D-loop; other site 1052585003063 H-loop/switch region; other site 1052585003064 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052585003065 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1052585003066 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 1052585003067 Walker A/P-loop; other site 1052585003068 ATP binding site [chemical binding]; other site 1052585003069 Q-loop/lid; other site 1052585003070 ABC transporter signature motif; other site 1052585003071 Walker B; other site 1052585003072 D-loop; other site 1052585003073 H-loop/switch region; other site 1052585003074 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1052585003075 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1052585003076 NAD binding site [chemical binding]; other site 1052585003077 substrate binding site [chemical binding]; other site 1052585003078 putative active site [active] 1052585003079 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1052585003080 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1052585003081 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1052585003082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1052585003083 Protein of unknown function (DUF964); Region: DUF964; cl01483 1052585003084 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1052585003085 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1052585003086 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585003087 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1052585003088 active site 1052585003089 motif I; other site 1052585003090 motif II; other site 1052585003091 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1052585003092 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 1052585003093 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052585003094 FeS/SAM binding site; other site 1052585003095 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1052585003096 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1052585003097 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1052585003098 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1052585003099 enoyl-CoA hydratase; Provisional; Region: PRK07659 1052585003100 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1052585003101 substrate binding site [chemical binding]; other site 1052585003102 oxyanion hole (OAH) forming residues; other site 1052585003103 trimer interface [polypeptide binding]; other site 1052585003104 YhzD-like protein; Region: YhzD; pfam14120 1052585003105 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1052585003106 This subfamily is involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity. In eubacteria and archaea, the typical organization consists of one ABC and one or two IMs. Eukaryote systems of the ABCA subfamily...; Region: ABC_putative_ATPase; cd03269 1052585003107 Walker A/P-loop; other site 1052585003108 ATP binding site [chemical binding]; other site 1052585003109 Q-loop/lid; other site 1052585003110 ABC transporter signature motif; other site 1052585003111 Walker B; other site 1052585003112 D-loop; other site 1052585003113 H-loop/switch region; other site 1052585003114 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1052585003115 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1052585003116 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1052585003117 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1052585003118 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1052585003119 active site 1052585003120 metal binding site [ion binding]; metal-binding site 1052585003121 DNA binding site [nucleotide binding] 1052585003122 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1052585003123 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585003124 ABC transporter signature motif; other site 1052585003125 Walker B; other site 1052585003126 D-loop; other site 1052585003127 H-loop/switch region; other site 1052585003128 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1052585003129 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 1052585003130 generic binding surface II; other site 1052585003131 generic binding surface I; other site 1052585003132 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052585003133 Zn2+ binding site [ion binding]; other site 1052585003134 Mg2+ binding site [ion binding]; other site 1052585003135 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 1052585003136 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1052585003137 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 1052585003138 PPIC-type PPIASE domain; Region: Rotamase; cl08278 1052585003139 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1052585003140 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 1052585003141 transcriptional regulator Hpr; Provisional; Region: PRK13777 1052585003142 Helix-turn-helix domains; Region: HTH; cl00088 1052585003143 YtxH-like protein; Region: YtxH; cl02079 1052585003144 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1052585003145 homodimer interface [polypeptide binding]; other site 1052585003146 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1052585003147 substrate-cofactor binding pocket; other site 1052585003148 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585003149 catalytic residue [active] 1052585003150 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1052585003151 HIT family signature motif; other site 1052585003152 catalytic residue [active] 1052585003153 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1052585003154 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1052585003155 Walker A/P-loop; other site 1052585003156 ATP binding site [chemical binding]; other site 1052585003157 Q-loop/lid; other site 1052585003158 ABC transporter signature motif; other site 1052585003159 Walker B; other site 1052585003160 D-loop; other site 1052585003161 H-loop/switch region; other site 1052585003162 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 1052585003163 EcsC protein family; Region: EcsC; pfam12787 1052585003164 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1052585003165 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1052585003166 metal binding site [ion binding]; metal-binding site 1052585003167 dimer interface [polypeptide binding]; other site 1052585003168 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1052585003169 Transglycosylase; Region: Transgly; cl07896 1052585003170 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1052585003171 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052585003172 methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463 1052585003173 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1052585003174 substrate binding site [chemical binding]; other site 1052585003175 active site 1052585003176 ferrochelatase; Provisional; Region: PRK12435 1052585003177 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1052585003178 C-terminal domain interface [polypeptide binding]; other site 1052585003179 active site 1052585003180 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1052585003181 active site 1052585003182 N-terminal domain interface [polypeptide binding]; other site 1052585003183 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1052585003184 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585003185 SEA domain; Region: SEA; cl02507 1052585003186 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585003187 Helix-turn-helix domains; Region: HTH; cl00088 1052585003188 Predicted membrane protein [Function unknown]; Region: COG1511 1052585003189 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1052585003190 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1052585003191 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1052585003192 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 1052585003193 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1052585003194 dimer interface [polypeptide binding]; other site 1052585003195 active site 1052585003196 CoA binding pocket [chemical binding]; other site 1052585003197 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 1052585003198 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1052585003199 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1052585003200 putative oligomer interface [polypeptide binding]; other site 1052585003201 putative active site [active] 1052585003202 metal binding site [ion binding]; metal-binding site 1052585003203 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 1052585003204 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1052585003205 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1052585003206 YhfH-like protein; Region: YhfH; pfam14149 1052585003207 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052585003208 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1052585003209 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1052585003210 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1052585003211 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1052585003212 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1052585003213 NAD(P) binding site [chemical binding]; other site 1052585003214 putative active site [active] 1052585003215 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1052585003216 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585003217 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052585003218 Peptidase family M48; Region: Peptidase_M48; cl12018 1052585003219 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1052585003220 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1052585003221 active site 1052585003222 catalytic residues [active] 1052585003223 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1052585003224 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585003225 Coenzyme A binding pocket [chemical binding]; other site 1052585003226 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 1052585003227 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1052585003228 putative NADP binding site [chemical binding]; other site 1052585003229 putative dimer interface [polypeptide binding]; other site 1052585003230 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1052585003231 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1052585003232 siderophore binding site; other site 1052585003233 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1052585003234 catalytic core [active] 1052585003235 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 1052585003236 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1052585003237 dimer interface [polypeptide binding]; other site 1052585003238 active site 1052585003239 acyl-CoA synthetase; Validated; Region: PRK07638 1052585003240 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585003241 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052585003242 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 1052585003243 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 1052585003244 heme-binding site [chemical binding]; other site 1052585003245 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 1052585003246 Active site flap [active] 1052585003247 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052585003248 dimer interface [polypeptide binding]; other site 1052585003249 putative CheW interface [polypeptide binding]; other site 1052585003250 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585003251 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1052585003252 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 1052585003253 [2Fe-2S] cluster binding site [ion binding]; other site 1052585003254 short chain dehydrogenase; Provisional; Region: PRK06701 1052585003255 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1052585003256 NAD binding site [chemical binding]; other site 1052585003257 metal binding site [ion binding]; metal-binding site 1052585003258 active site 1052585003259 IDEAL domain; Region: IDEAL; cl07452 1052585003260 ComK protein; Region: ComK; cl11560 1052585003261 oxidoreductase; Provisional; Region: PRK07985 1052585003262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585003263 NAD(P) binding site [chemical binding]; other site 1052585003264 active site 1052585003265 Sodium:solute symporter family; Region: SSF; cl00456 1052585003266 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1052585003267 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1052585003268 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1052585003269 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1052585003270 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1052585003271 Catalytic site [active] 1052585003272 hypothetical protein; Provisional; Region: PRK08244 1052585003273 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585003274 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585003275 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585003276 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585003277 Helix-turn-helix domains; Region: HTH; cl00088 1052585003278 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1052585003279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585003280 putative substrate translocation pore; other site 1052585003281 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585003282 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052585003283 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1052585003284 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1052585003285 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585003286 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1052585003287 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1052585003288 inhibitor-cofactor binding pocket; inhibition site 1052585003289 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585003290 catalytic residue [active] 1052585003291 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052585003292 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052585003293 DNA binding site [nucleotide binding] 1052585003294 domain linker motif; other site 1052585003295 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1052585003296 putative dimerization interface [polypeptide binding]; other site 1052585003297 putative ligand binding site [chemical binding]; other site 1052585003298 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1052585003299 Putative ammonia monooxygenase; Region: AmoA; pfam05145 1052585003300 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1052585003301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585003302 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585003303 putative substrate translocation pore; other site 1052585003304 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1052585003305 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1052585003306 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1052585003307 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1052585003308 dinuclear metal binding motif [ion binding]; other site 1052585003309 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1052585003310 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1052585003311 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1052585003312 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585003313 Family description; Region: UvrD_C_2; cl15862 1052585003314 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1052585003315 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1052585003316 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1052585003317 active site 1052585003318 metal binding site [ion binding]; metal-binding site 1052585003319 DNA binding site [nucleotide binding] 1052585003320 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1052585003321 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1052585003322 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 1052585003323 Walker A/P-loop; other site 1052585003324 ATP binding site [chemical binding]; other site 1052585003325 Q-loop/lid; other site 1052585003326 ABC transporter signature motif; other site 1052585003327 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1052585003328 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 1052585003329 ABC transporter signature motif; other site 1052585003330 Walker B; other site 1052585003331 D-loop; other site 1052585003332 H-loop/switch region; other site 1052585003333 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1052585003334 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1052585003335 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1052585003336 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1052585003337 Spore germination protein GerPC; Region: GerPC; pfam10737 1052585003338 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 1052585003339 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1052585003340 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1052585003341 CotH protein; Region: CotH; pfam08757 1052585003342 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1052585003343 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1052585003344 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 1052585003345 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1052585003346 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 1052585003347 active site 1052585003348 catalytic triad [active] 1052585003349 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 1052585003350 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1052585003351 active site 1052585003352 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1052585003353 dimer interface [polypeptide binding]; other site 1052585003354 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1052585003355 Ligand Binding Site [chemical binding]; other site 1052585003356 Molecular Tunnel; other site 1052585003357 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1052585003358 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1052585003359 substrate binding pocket [chemical binding]; other site 1052585003360 substrate-Mg2+ binding site; other site 1052585003361 aspartate-rich region 1; other site 1052585003362 aspartate-rich region 2; other site 1052585003363 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1052585003364 MatE; Region: MatE; cl10513 1052585003365 MatE; Region: MatE; cl10513 1052585003366 Cupin domain; Region: Cupin_2; cl09118 1052585003367 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052585003368 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052585003369 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052585003370 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052585003371 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052585003372 DNA binding site [nucleotide binding] 1052585003373 domain linker motif; other site 1052585003374 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1052585003375 dimerization interface [polypeptide binding]; other site 1052585003376 ligand binding site [chemical binding]; other site 1052585003377 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052585003378 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585003379 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1052585003380 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1052585003381 LysE type translocator; Region: LysE; cl00565 1052585003382 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1052585003383 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585003384 DNA-binding site [nucleotide binding]; DNA binding site 1052585003385 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052585003386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585003387 homodimer interface [polypeptide binding]; other site 1052585003388 catalytic residue [active] 1052585003389 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1052585003390 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1052585003391 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1052585003392 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052585003393 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052585003394 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 1052585003395 ligand-binding site [chemical binding]; other site 1052585003396 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1052585003397 ATP-sulfurylase; Region: ATPS; cd00517 1052585003398 active site 1052585003399 HXXH motif; other site 1052585003400 flexible loop; other site 1052585003401 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1052585003402 Active Sites [active] 1052585003403 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 1052585003404 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 1052585003405 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782 1052585003406 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1052585003407 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052585003408 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1052585003409 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1052585003410 active site pocket [active] 1052585003411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585003412 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585003413 putative substrate translocation pore; other site 1052585003414 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1052585003415 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052585003416 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052585003417 Protein of unknown function (DUF520); Region: DUF520; cl00723 1052585003418 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1052585003419 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1052585003420 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1052585003421 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 1052585003422 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 1052585003423 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 1052585003424 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 1052585003425 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1052585003426 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585003427 motif II; other site 1052585003428 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585003429 esterase; Provisional; Region: PRK10566 1052585003430 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052585003431 Domain of unknown function DUF59; Region: DUF59; cl00941 1052585003432 Proteolipid membrane potential modulator; Region: Pmp3; cl00431 1052585003433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585003434 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1052585003435 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585003436 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1052585003437 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1052585003438 heterotetramer interface [polypeptide binding]; other site 1052585003439 active site pocket [active] 1052585003440 cleavage site 1052585003441 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1052585003442 nucleotide binding site [chemical binding]; other site 1052585003443 N-acetyl-L-glutamate binding site [chemical binding]; other site 1052585003444 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 1052585003445 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052585003446 inhibitor-cofactor binding pocket; inhibition site 1052585003447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585003448 catalytic residue [active] 1052585003449 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 1052585003450 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 1052585003451 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1052585003452 catalytic site [active] 1052585003453 subunit interface [polypeptide binding]; other site 1052585003454 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 1052585003455 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052585003456 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1052585003457 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1052585003458 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052585003459 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1052585003460 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1052585003461 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1052585003462 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585003463 YjzC-like protein; Region: YjzC; pfam14168 1052585003464 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1052585003465 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1052585003466 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1052585003467 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1052585003468 putative ligand binding site [chemical binding]; other site 1052585003469 ComZ; Region: ComZ; pfam10815 1052585003470 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1052585003471 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1052585003472 dimer interface [polypeptide binding]; other site 1052585003473 active site 1052585003474 CoA binding pocket [chemical binding]; other site 1052585003475 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1052585003476 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1052585003477 dimer interface [polypeptide binding]; other site 1052585003478 active site 1052585003479 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 1052585003480 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1052585003481 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1052585003482 Walker A/P-loop; other site 1052585003483 ATP binding site [chemical binding]; other site 1052585003484 Q-loop/lid; other site 1052585003485 ABC transporter signature motif; other site 1052585003486 Walker B; other site 1052585003487 D-loop; other site 1052585003488 H-loop/switch region; other site 1052585003489 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1052585003490 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1052585003491 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1052585003492 Walker A/P-loop; other site 1052585003493 ATP binding site [chemical binding]; other site 1052585003494 Q-loop/lid; other site 1052585003495 ABC transporter signature motif; other site 1052585003496 Walker B; other site 1052585003497 D-loop; other site 1052585003498 H-loop/switch region; other site 1052585003499 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1052585003500 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 1052585003501 peptide binding site [polypeptide binding]; other site 1052585003502 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1052585003503 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1052585003504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585003505 dimer interface [polypeptide binding]; other site 1052585003506 conserved gate region; other site 1052585003507 putative PBP binding loops; other site 1052585003508 ABC-ATPase subunit interface; other site 1052585003509 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1052585003510 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1052585003511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585003512 dimer interface [polypeptide binding]; other site 1052585003513 conserved gate region; other site 1052585003514 putative PBP binding loops; other site 1052585003515 ABC-ATPase subunit interface; other site 1052585003516 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 1052585003517 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1052585003518 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1052585003519 active site 1052585003520 HIGH motif; other site 1052585003521 dimer interface [polypeptide binding]; other site 1052585003522 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1052585003523 KMSKS motif; other site 1052585003524 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1052585003525 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1052585003526 peptide binding site [polypeptide binding]; other site 1052585003527 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1052585003528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585003529 dimer interface [polypeptide binding]; other site 1052585003530 conserved gate region; other site 1052585003531 putative PBP binding loops; other site 1052585003532 ABC-ATPase subunit interface; other site 1052585003533 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1052585003534 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1052585003535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585003536 dimer interface [polypeptide binding]; other site 1052585003537 conserved gate region; other site 1052585003538 putative PBP binding loops; other site 1052585003539 ABC-ATPase subunit interface; other site 1052585003540 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1052585003541 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1052585003542 Walker A/P-loop; other site 1052585003543 ATP binding site [chemical binding]; other site 1052585003544 Q-loop/lid; other site 1052585003545 ABC transporter signature motif; other site 1052585003546 Walker B; other site 1052585003547 D-loop; other site 1052585003548 H-loop/switch region; other site 1052585003549 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1052585003550 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1052585003551 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1052585003552 Walker A/P-loop; other site 1052585003553 ATP binding site [chemical binding]; other site 1052585003554 Q-loop/lid; other site 1052585003555 ABC transporter signature motif; other site 1052585003556 Walker B; other site 1052585003557 D-loop; other site 1052585003558 H-loop/switch region; other site 1052585003559 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1052585003560 H+ Antiporter protein; Region: 2A0121; TIGR00900 1052585003561 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1052585003562 ArsC family; Region: ArsC; pfam03960 1052585003563 putative catalytic residues [active] 1052585003564 thiol/disulfide switch; other site 1052585003565 Integral membrane protein TerC family; Region: TerC; cl10468 1052585003566 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 1052585003567 Competence protein CoiA-like family; Region: CoiA; cl11541 1052585003568 oligoendopeptidase F; Region: pepF; TIGR00181 1052585003569 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1052585003570 active site 1052585003571 Zn binding site [ion binding]; other site 1052585003572 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1052585003573 Thioredoxin; Region: Thioredoxin_5; pfam13743 1052585003574 catalytic residues [active] 1052585003575 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1052585003576 apolar tunnel; other site 1052585003577 heme binding site [chemical binding]; other site 1052585003578 dimerization interface [polypeptide binding]; other site 1052585003579 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1052585003580 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1052585003581 catalytic residue [active] 1052585003582 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1052585003583 putative active site [active] 1052585003584 putative metal binding residues [ion binding]; other site 1052585003585 signature motif; other site 1052585003586 putative triphosphate binding site [ion binding]; other site 1052585003587 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1052585003588 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1052585003589 synthetase active site [active] 1052585003590 NTP binding site [chemical binding]; other site 1052585003591 metal binding site [ion binding]; metal-binding site 1052585003592 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1052585003593 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1052585003594 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 1052585003595 active site 1052585003596 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 1052585003597 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 1052585003598 active site 1052585003599 metal binding site [ion binding]; metal-binding site 1052585003600 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1052585003601 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1052585003602 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1052585003603 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585003604 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1052585003605 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 1052585003606 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1052585003607 thiamine phosphate binding site [chemical binding]; other site 1052585003608 active site 1052585003609 pyrophosphate binding site [ion binding]; other site 1052585003610 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1052585003611 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585003612 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1052585003613 thiS-thiF/thiG interaction site; other site 1052585003614 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1052585003615 ThiS interaction site; other site 1052585003616 putative active site [active] 1052585003617 tetramer interface [polypeptide binding]; other site 1052585003618 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1052585003619 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1052585003620 ATP binding site [chemical binding]; other site 1052585003621 substrate interface [chemical binding]; other site 1052585003622 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1052585003623 dimer interface [polypeptide binding]; other site 1052585003624 substrate binding site [chemical binding]; other site 1052585003625 ATP binding site [chemical binding]; other site 1052585003626 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 1052585003627 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1052585003628 NAD binding site [chemical binding]; other site 1052585003629 homotetramer interface [polypeptide binding]; other site 1052585003630 homodimer interface [polypeptide binding]; other site 1052585003631 substrate binding site [chemical binding]; other site 1052585003632 active site 1052585003633 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 1052585003634 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1052585003635 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 1052585003636 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1052585003637 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1052585003638 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 1052585003639 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1052585003640 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 1052585003641 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1052585003642 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585003643 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585003644 Family description; Region: UvrD_C_2; cl15862 1052585003645 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585003646 Coenzyme A binding pocket [chemical binding]; other site 1052585003647 hypothetical protein; Provisional; Region: PRK13679 1052585003648 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1052585003649 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052585003650 Putative esterase; Region: Esterase; pfam00756 1052585003651 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1052585003652 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1052585003653 homodimer interface [polypeptide binding]; other site 1052585003654 substrate-cofactor binding pocket; other site 1052585003655 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585003656 catalytic residue [active] 1052585003657 cystathionine beta-lyase; Provisional; Region: PRK08064 1052585003658 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1052585003659 homodimer interface [polypeptide binding]; other site 1052585003660 substrate-cofactor binding pocket; other site 1052585003661 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585003662 catalytic residue [active] 1052585003663 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052585003664 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052585003665 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052585003666 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1052585003667 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1052585003668 Helix-turn-helix domains; Region: HTH; cl00088 1052585003669 PRD domain; Region: PRD; cl15445 1052585003670 PRD domain; Region: PRD; cl15445 1052585003671 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1052585003672 P-loop; other site 1052585003673 active site 1052585003674 phosphorylation site [posttranslational modification] 1052585003675 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1052585003676 active site 1052585003677 phosphorylation site [posttranslational modification] 1052585003678 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1052585003679 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1052585003680 P-loop; other site 1052585003681 active site 1052585003682 phosphorylation site [posttranslational modification] 1052585003683 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1052585003684 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1052585003685 active site 1052585003686 phosphorylation site [posttranslational modification] 1052585003687 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1052585003688 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 1052585003689 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052585003690 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052585003691 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1052585003692 putative deacylase active site [active] 1052585003693 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1052585003694 UbiA prenyltransferase family; Region: UbiA; cl00337 1052585003695 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1052585003696 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1052585003697 Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947 1052585003698 NodB motif; other site 1052585003699 active site 1052585003700 catalytic site [active] 1052585003701 Zn binding site [ion binding]; other site 1052585003702 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 1052585003703 Putative motility protein; Region: YjfB_motility; pfam14070 1052585003704 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 1052585003705 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 1052585003706 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1052585003707 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1052585003708 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 1052585003709 4Fe-4S binding domain; Region: Fer4; cl02805 1052585003710 4Fe-4S binding domain; Region: Fer4; cl02805 1052585003711 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1052585003712 [4Fe-4S] binding site [ion binding]; other site 1052585003713 molybdopterin cofactor binding site; other site 1052585003714 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1052585003715 molybdopterin cofactor binding site; other site 1052585003716 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 1052585003717 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1052585003718 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1052585003719 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1052585003720 nudix motif; other site 1052585003721 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1052585003722 Cytochrome P450; Region: p450; pfam00067 1052585003723 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1052585003724 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1052585003725 active site 1052585003726 TDP-binding site; other site 1052585003727 acceptor substrate-binding pocket; other site 1052585003728 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1052585003729 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1052585003730 active site 1052585003731 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 1052585003732 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1052585003733 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 1052585003734 Walker A/P-loop; other site 1052585003735 ATP binding site [chemical binding]; other site 1052585003736 Q-loop/lid; other site 1052585003737 ABC transporter signature motif; other site 1052585003738 Walker B; other site 1052585003739 D-loop; other site 1052585003740 H-loop/switch region; other site 1052585003741 EamA-like transporter family; Region: EamA; cl01037 1052585003742 Cupin domain; Region: Cupin_2; cl09118 1052585003743 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 1052585003744 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1052585003745 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052585003746 Glucuronate isomerase; Region: UxaC; cl00829 1052585003747 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1052585003748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585003749 putative substrate translocation pore; other site 1052585003750 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 1052585003751 putative oxidoreductase; Provisional; Region: PRK10083 1052585003752 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1052585003753 putative NAD(P) binding site [chemical binding]; other site 1052585003754 catalytic Zn binding site [ion binding]; other site 1052585003755 structural Zn binding site [ion binding]; other site 1052585003756 mannonate dehydratase; Provisional; Region: PRK03906 1052585003757 mannonate dehydratase; Region: uxuA; TIGR00695 1052585003758 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 1052585003759 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1052585003760 putative NAD(P) binding site [chemical binding]; other site 1052585003761 active site 1052585003762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585003763 D-galactonate transporter; Region: 2A0114; TIGR00893 1052585003764 putative substrate translocation pore; other site 1052585003765 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052585003766 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052585003767 DNA binding site [nucleotide binding] 1052585003768 domain linker motif; other site 1052585003769 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1052585003770 dimerization interface [polypeptide binding]; other site 1052585003771 ligand binding site [chemical binding]; other site 1052585003772 altronate oxidoreductase; Provisional; Region: PRK03643 1052585003773 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1052585003774 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1052585003775 SAF domain; Region: SAF; cl00555 1052585003776 Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721 1052585003777 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1052585003778 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 1052585003779 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1052585003780 DinB superfamily; Region: DinB_2; pfam12867 1052585003781 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 1052585003782 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585003783 Walker A motif; other site 1052585003784 ATP binding site [chemical binding]; other site 1052585003785 Walker B motif; other site 1052585003786 arginine finger; other site 1052585003787 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052585003788 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1052585003789 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1052585003790 YCII-related domain; Region: YCII; cl00999 1052585003791 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1052585003792 amidase catalytic site [active] 1052585003793 Zn binding residues [ion binding]; other site 1052585003794 substrate binding site [chemical binding]; other site 1052585003795 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1052585003796 putative peptidoglycan binding site; other site 1052585003797 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1052585003798 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 1052585003799 Protein of unknown function (DUF867); Region: DUF867; cl01713 1052585003800 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1052585003801 dimanganese center [ion binding]; other site 1052585003802 Domain of unknown function (DUF955); Region: DUF955; cl01076 1052585003803 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052585003804 non-specific DNA binding site [nucleotide binding]; other site 1052585003805 salt bridge; other site 1052585003806 sequence-specific DNA binding site [nucleotide binding]; other site 1052585003807 DNA replication protein DnaC; Validated; Region: PRK07952 1052585003808 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585003809 Walker A motif; other site 1052585003810 ATP binding site [chemical binding]; other site 1052585003811 Walker B motif; other site 1052585003812 positive control sigma-like factor; Validated; Region: PRK06930 1052585003813 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052585003814 DNA binding residues [nucleotide binding] 1052585003815 Phage terminase small subunit; Region: Phage_terminase; pfam10668 1052585003816 Terminase small subunit; Region: Terminase_2; cl01513 1052585003817 Phage terminase large subunit; Region: Terminase_3; cl12054 1052585003818 Terminase-like family; Region: Terminase_6; pfam03237 1052585003819 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1052585003820 phage portal protein, PBSX family; Region: portal_PBSX; TIGR01540 1052585003821 Phage capsid family; Region: Phage_capsid; pfam05065 1052585003822 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 1052585003823 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 1052585003824 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1052585003825 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 1052585003826 Phage XkdN-like protein; Region: XkdN; pfam08890 1052585003827 Dynein heavy chain, N-terminal region 1; Region: DHC_N1; pfam08385 1052585003828 Phage-related protein [Function unknown]; Region: COG5412 1052585003829 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1052585003830 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 1052585003831 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1052585003832 catalytic residue [active] 1052585003833 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1052585003834 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1052585003835 putative peptidoglycan binding site; other site 1052585003836 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 1052585003837 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 1052585003838 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 1052585003839 Baseplate J-like protein; Region: Baseplate_J; cl01294 1052585003840 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 1052585003841 XkdW protein; Region: XkdW; pfam09636 1052585003842 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 1052585003843 Haemolysin XhlA; Region: XhlA; pfam10779 1052585003844 Phage lysis protein, holin; Region: Phage_holin; cl04675 1052585003845 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1052585003846 amidase catalytic site [active] 1052585003847 Zn binding residues [ion binding]; other site 1052585003848 substrate binding site [chemical binding]; other site 1052585003849 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1052585003850 putative peptidoglycan binding site; other site 1052585003851 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1052585003852 Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185 1052585003853 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 1052585003854 Phosphate transporter family; Region: PHO4; cl00396 1052585003855 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1052585003856 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 1052585003857 Spore germination protein; Region: Spore_permease; cl15802 1052585003858 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1052585003859 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052585003860 Zn binding site [ion binding]; other site 1052585003861 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1052585003862 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052585003863 Zn binding site [ion binding]; other site 1052585003864 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 1052585003865 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1052585003866 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1052585003867 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1052585003868 Ligand binding site; other site 1052585003869 Putative Catalytic site; other site 1052585003870 DXD motif; other site 1052585003871 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1052585003872 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1052585003873 protein binding site [polypeptide binding]; other site 1052585003874 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585003875 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1052585003876 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cd00281 1052585003877 SxDxEG motif; other site 1052585003878 active site 1052585003879 metal binding site [ion binding]; metal-binding site 1052585003880 homopentamer interface [polypeptide binding]; other site 1052585003881 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1052585003882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585003883 dimer interface [polypeptide binding]; other site 1052585003884 conserved gate region; other site 1052585003885 putative PBP binding loops; other site 1052585003886 ABC-ATPase subunit interface; other site 1052585003887 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1052585003888 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1052585003889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585003890 putative PBP binding loops; other site 1052585003891 dimer interface [polypeptide binding]; other site 1052585003892 ABC-ATPase subunit interface; other site 1052585003893 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1052585003894 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1052585003895 Walker A/P-loop; other site 1052585003896 ATP binding site [chemical binding]; other site 1052585003897 Q-loop/lid; other site 1052585003898 ABC transporter signature motif; other site 1052585003899 Walker B; other site 1052585003900 D-loop; other site 1052585003901 H-loop/switch region; other site 1052585003902 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1052585003903 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1052585003904 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1052585003905 peptide binding site [polypeptide binding]; other site 1052585003906 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1052585003907 dimer interface [polypeptide binding]; other site 1052585003908 catalytic triad [active] 1052585003909 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1052585003910 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1052585003911 active site 1052585003912 NlpC/P60 family; Region: NLPC_P60; cl11438 1052585003913 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1052585003914 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 1052585003915 Walker A/P-loop; other site 1052585003916 ATP binding site [chemical binding]; other site 1052585003917 Q-loop/lid; other site 1052585003918 ABC transporter signature motif; other site 1052585003919 Walker B; other site 1052585003920 D-loop; other site 1052585003921 H-loop/switch region; other site 1052585003922 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1052585003923 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1052585003924 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1052585003925 Amidinotransferase; Region: Amidinotransf; cl12043 1052585003926 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1052585003927 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1052585003928 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1052585003929 heme-binding site [chemical binding]; other site 1052585003930 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1052585003931 FAD binding pocket [chemical binding]; other site 1052585003932 FAD binding motif [chemical binding]; other site 1052585003933 phosphate binding motif [ion binding]; other site 1052585003934 beta-alpha-beta structure motif; other site 1052585003935 NAD binding pocket [chemical binding]; other site 1052585003936 Heme binding pocket [chemical binding]; other site 1052585003937 Protein of unknown function (DUF421); Region: DUF421; cl00990 1052585003938 DinB superfamily; Region: DinB_2; pfam12867 1052585003939 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1052585003940 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052585003941 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1052585003942 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1052585003943 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1052585003944 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1052585003945 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1052585003946 putative active site [active] 1052585003947 putative substrate binding site [chemical binding]; other site 1052585003948 putative cosubstrate binding site; other site 1052585003949 catalytic site [active] 1052585003950 glutamate 5-kinase; Region: proB; TIGR01027 1052585003951 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1052585003952 nucleotide binding site [chemical binding]; other site 1052585003953 homotetrameric interface [polypeptide binding]; other site 1052585003954 putative phosphate binding site [ion binding]; other site 1052585003955 putative allosteric binding site; other site 1052585003956 PUA domain; Region: PUA; cl00607 1052585003957 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1052585003958 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1052585003959 putative catalytic cysteine [active] 1052585003960 OsmC-like protein; Region: OsmC; cl00767 1052585003961 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585003962 Helix-turn-helix domains; Region: HTH; cl00088 1052585003963 OsmC-like protein; Region: OsmC; cl00767 1052585003964 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1052585003965 putative metal binding site; other site 1052585003966 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585003967 binding surface 1052585003968 TPR motif; other site 1052585003969 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1052585003970 nucleoside/Zn binding site; other site 1052585003971 dimer interface [polypeptide binding]; other site 1052585003972 catalytic motif [active] 1052585003973 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1052585003974 catalytic core [active] 1052585003975 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1052585003976 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1052585003977 THF binding site; other site 1052585003978 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1052585003979 substrate binding site [chemical binding]; other site 1052585003980 THF binding site; other site 1052585003981 zinc-binding site [ion binding]; other site 1052585003982 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1052585003983 active site 1052585003984 catalytic residues [active] 1052585003985 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1052585003986 Cobalt transport protein; Region: CbiQ; cl00463 1052585003987 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1052585003988 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 1052585003989 Walker A/P-loop; other site 1052585003990 ATP binding site [chemical binding]; other site 1052585003991 Q-loop/lid; other site 1052585003992 ABC transporter signature motif; other site 1052585003993 Walker B; other site 1052585003994 D-loop; other site 1052585003995 H-loop/switch region; other site 1052585003996 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 1052585003997 Walker A/P-loop; other site 1052585003998 ATP binding site [chemical binding]; other site 1052585003999 Q-loop/lid; other site 1052585004000 ABC transporter signature motif; other site 1052585004001 Walker B; other site 1052585004002 D-loop; other site 1052585004003 H-loop/switch region; other site 1052585004004 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1052585004005 YKOF-related Family; Region: Ykof; pfam07615 1052585004006 YKOF-related Family; Region: Ykof; pfam07615 1052585004007 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052585004008 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585004009 active site 1052585004010 phosphorylation site [posttranslational modification] 1052585004011 intermolecular recognition site; other site 1052585004012 dimerization interface [polypeptide binding]; other site 1052585004013 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052585004014 DNA binding site [nucleotide binding] 1052585004015 Predicted membrane protein [Function unknown]; Region: COG3212 1052585004016 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 1052585004017 Predicted membrane protein [Function unknown]; Region: COG3212 1052585004018 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 1052585004019 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 1052585004020 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1052585004021 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 1052585004022 MgtE intracellular N domain; Region: MgtE_N; cl15244 1052585004023 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1052585004024 Divalent cation transporter; Region: MgtE; cl00786 1052585004025 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1052585004026 DNA binding residues [nucleotide binding] 1052585004027 putative dimer interface [polypeptide binding]; other site 1052585004028 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585004029 Helix-turn-helix domains; Region: HTH; cl00088 1052585004030 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 1052585004031 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1052585004032 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1052585004033 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1052585004034 putative active site [active] 1052585004035 putative metal binding site [ion binding]; other site 1052585004036 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 1052585004037 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1052585004038 Ligand binding site; other site 1052585004039 Putative Catalytic site; other site 1052585004040 DXD motif; other site 1052585004041 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 1052585004042 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1052585004043 active site 1052585004044 DNA binding site [nucleotide binding] 1052585004045 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 1052585004046 nucleotide binding site [chemical binding]; other site 1052585004047 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1052585004048 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1052585004049 putative DNA binding site [nucleotide binding]; other site 1052585004050 putative homodimer interface [polypeptide binding]; other site 1052585004051 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1052585004052 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1052585004053 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1052585004054 PAS domain; Region: PAS_9; pfam13426 1052585004055 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1052585004056 metal binding site [ion binding]; metal-binding site 1052585004057 active site 1052585004058 I-site; other site 1052585004059 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1052585004060 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1052585004061 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1052585004062 Integral membrane protein TerC family; Region: TerC; cl10468 1052585004063 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 1052585004064 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052585004065 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 1052585004066 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 1052585004067 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1052585004068 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1052585004069 Peptidase family M48; Region: Peptidase_M48; cl12018 1052585004070 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1052585004071 Cation transport protein; Region: TrkH; cl10514 1052585004072 OpgC protein; Region: OpgC_C; cl00792 1052585004073 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1052585004074 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1052585004075 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1052585004076 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1052585004077 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1052585004078 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1052585004079 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1052585004080 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1052585004081 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052585004082 dimer interface [polypeptide binding]; other site 1052585004083 phosphorylation site [posttranslational modification] 1052585004084 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585004085 ATP binding site [chemical binding]; other site 1052585004086 Mg2+ binding site [ion binding]; other site 1052585004087 G-X-G motif; other site 1052585004088 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1052585004089 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1052585004090 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1052585004091 DNA binding site [nucleotide binding] 1052585004092 active site 1052585004093 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1052585004094 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 1052585004095 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052585004096 Phosphotransferase enzyme family; Region: APH; pfam01636 1052585004097 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1052585004098 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1052585004099 putative active site [active] 1052585004100 catalytic triad [active] 1052585004101 putative dimer interface [polypeptide binding]; other site 1052585004102 transaminase; Reviewed; Region: PRK08068 1052585004103 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052585004104 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585004105 homodimer interface [polypeptide binding]; other site 1052585004106 catalytic residue [active] 1052585004107 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: salvage_mtnW; TIGR03332 1052585004108 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 1052585004109 dimer interface [polypeptide binding]; other site 1052585004110 active site 1052585004111 catalytic residue [active] 1052585004112 metal binding site [ion binding]; metal-binding site 1052585004113 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1052585004114 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585004115 motif II; other site 1052585004116 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1052585004117 intersubunit interface [polypeptide binding]; other site 1052585004118 active site 1052585004119 Zn2+ binding site [ion binding]; other site 1052585004120 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1052585004121 Cupin domain; Region: Cupin_2; cl09118 1052585004122 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 1052585004123 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1052585004124 Cache domain; Region: Cache_1; pfam02743 1052585004125 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1052585004126 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052585004127 dimer interface [polypeptide binding]; other site 1052585004128 phosphorylation site [posttranslational modification] 1052585004129 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585004130 ATP binding site [chemical binding]; other site 1052585004131 Mg2+ binding site [ion binding]; other site 1052585004132 G-X-G motif; other site 1052585004133 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585004134 Helix-turn-helix domains; Region: HTH; cl00088 1052585004135 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 1052585004136 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1052585004137 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1052585004138 ligand binding site [chemical binding]; other site 1052585004139 flagellar motor protein MotA; Validated; Region: PRK08124 1052585004140 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1052585004141 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585004142 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1052585004143 Walker A motif; other site 1052585004144 ATP binding site [chemical binding]; other site 1052585004145 Walker B motif; other site 1052585004146 arginine finger; other site 1052585004147 UvrB/uvrC motif; Region: UVR; pfam02151 1052585004148 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585004149 Walker A motif; other site 1052585004150 ATP binding site [chemical binding]; other site 1052585004151 Walker B motif; other site 1052585004152 arginine finger; other site 1052585004153 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1052585004154 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1052585004155 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1052585004156 Ligand Binding Site [chemical binding]; other site 1052585004157 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1052585004158 active site 1052585004159 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1052585004160 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1052585004161 FeS/SAM binding site; other site 1052585004162 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1052585004163 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1052585004164 putative peptidoglycan binding site; other site 1052585004165 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1052585004166 active site 1052585004167 Protein of unknown function (DUF3219); Region: DUF3219; pfam11514 1052585004168 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 1052585004169 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 1052585004170 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1052585004171 MatE; Region: MatE; cl10513 1052585004172 MatE; Region: MatE; cl10513 1052585004173 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1052585004174 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1052585004175 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1052585004176 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1052585004177 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1052585004178 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1052585004179 active site 1052585004180 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052585004181 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052585004182 DNA binding site [nucleotide binding] 1052585004183 domain linker motif; other site 1052585004184 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1052585004185 putative dimerization interface [polypeptide binding]; other site 1052585004186 putative ligand binding site [chemical binding]; other site 1052585004187 CAT RNA binding domain; Region: CAT_RBD; cl03904 1052585004188 PRD domain; Region: PRD; cl15445 1052585004189 PRD domain; Region: PRD; cl15445 1052585004190 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1052585004191 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1052585004192 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052585004193 active site turn [active] 1052585004194 phosphorylation site [posttranslational modification] 1052585004195 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1052585004196 HPr interaction site; other site 1052585004197 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1052585004198 active site 1052585004199 phosphorylation site [posttranslational modification] 1052585004200 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1052585004201 dimerization domain swap beta strand [polypeptide binding]; other site 1052585004202 regulatory protein interface [polypeptide binding]; other site 1052585004203 active site 1052585004204 regulatory phosphorylation site [posttranslational modification]; other site 1052585004205 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 1052585004206 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1052585004207 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1052585004208 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 1052585004209 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 1052585004210 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1052585004211 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052585004212 FeS/SAM binding site; other site 1052585004213 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052585004214 Cache domain; Region: Cache_1; pfam02743 1052585004215 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052585004216 dimerization interface [polypeptide binding]; other site 1052585004217 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052585004218 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052585004219 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052585004220 dimer interface [polypeptide binding]; other site 1052585004221 putative CheW interface [polypeptide binding]; other site 1052585004222 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585004223 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1052585004224 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1052585004225 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1052585004226 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1052585004227 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1052585004228 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052585004229 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052585004230 putative active site [active] 1052585004231 heme pocket [chemical binding]; other site 1052585004232 PAS fold; Region: PAS; pfam00989 1052585004233 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052585004234 putative active site [active] 1052585004235 heme pocket [chemical binding]; other site 1052585004236 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1052585004237 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1052585004238 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052585004239 dimer interface [polypeptide binding]; other site 1052585004240 phosphorylation site [posttranslational modification] 1052585004241 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585004242 ATP binding site [chemical binding]; other site 1052585004243 Mg2+ binding site [ion binding]; other site 1052585004244 G-X-G motif; other site 1052585004245 aminotransferase A; Validated; Region: PRK07683 1052585004246 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052585004247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585004248 homodimer interface [polypeptide binding]; other site 1052585004249 catalytic residue [active] 1052585004250 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1052585004251 putative CheA interaction surface; other site 1052585004252 Response regulator receiver domain; Region: Response_reg; pfam00072 1052585004253 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585004254 active site 1052585004255 phosphorylation site [posttranslational modification] 1052585004256 intermolecular recognition site; other site 1052585004257 dimerization interface [polypeptide binding]; other site 1052585004258 YkyB-like protein; Region: YkyB; pfam14177 1052585004259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585004260 H+ Antiporter protein; Region: 2A0121; TIGR00900 1052585004261 putative substrate translocation pore; other site 1052585004262 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1052585004263 putative peptidoglycan binding site; other site 1052585004264 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 1052585004265 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1052585004266 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1052585004267 putative active site [active] 1052585004268 putative metal binding site [ion binding]; other site 1052585004269 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1052585004270 short chain dehydrogenase; Provisional; Region: PRK07677 1052585004271 NAD(P) binding site [chemical binding]; other site 1052585004272 substrate binding site [chemical binding]; other site 1052585004273 homotetramer interface [polypeptide binding]; other site 1052585004274 active site 1052585004275 homodimer interface [polypeptide binding]; other site 1052585004276 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1052585004277 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 1052585004278 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 1052585004279 Protein of unknown function (DUF458); Region: DUF458; cl00861 1052585004280 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 1052585004281 FOG: CBS domain [General function prediction only]; Region: COG0517 1052585004282 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1052585004283 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052585004284 Helix-turn-helix domains; Region: HTH; cl00088 1052585004285 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052585004286 dimerization interface [polypeptide binding]; other site 1052585004287 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1052585004288 BNR repeat-like domain; Region: BNR_2; pfam13088 1052585004289 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1052585004290 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1052585004291 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1052585004292 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1052585004293 active site 1052585004294 trimer interface [polypeptide binding]; other site 1052585004295 substrate binding site [chemical binding]; other site 1052585004296 CoA binding site [chemical binding]; other site 1052585004297 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1052585004298 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1052585004299 metal binding site [ion binding]; metal-binding site 1052585004300 putative dimer interface [polypeptide binding]; other site 1052585004301 Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214 1052585004302 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1052585004303 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1052585004304 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1052585004305 dimer interface [polypeptide binding]; other site 1052585004306 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1052585004307 catalytic triad [active] 1052585004308 peroxidatic and resolving cysteines [active] 1052585004309 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1052585004310 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1052585004311 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1052585004312 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1052585004313 GTP binding site; other site 1052585004314 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 1052585004315 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1052585004316 ATP binding site [chemical binding]; other site 1052585004317 substrate interface [chemical binding]; other site 1052585004318 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1052585004319 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1052585004320 dimer interface [polypeptide binding]; other site 1052585004321 putative functional site; other site 1052585004322 putative MPT binding site; other site 1052585004323 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1052585004324 Walker A motif; other site 1052585004325 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1052585004326 MoaE homodimer interface [polypeptide binding]; other site 1052585004327 MoaD interaction [polypeptide binding]; other site 1052585004328 active site residues [active] 1052585004329 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1052585004330 MoaE interaction surface [polypeptide binding]; other site 1052585004331 MoeB interaction surface [polypeptide binding]; other site 1052585004332 thiocarboxylated glycine; other site 1052585004333 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052585004334 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1052585004335 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 1052585004336 Walker A/P-loop; other site 1052585004337 ATP binding site [chemical binding]; other site 1052585004338 Q-loop/lid; other site 1052585004339 ABC transporter signature motif; other site 1052585004340 Walker B; other site 1052585004341 D-loop; other site 1052585004342 H-loop/switch region; other site 1052585004343 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052585004344 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1052585004345 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 1052585004346 Walker A/P-loop; other site 1052585004347 ATP binding site [chemical binding]; other site 1052585004348 Q-loop/lid; other site 1052585004349 ABC transporter signature motif; other site 1052585004350 Walker B; other site 1052585004351 D-loop; other site 1052585004352 H-loop/switch region; other site 1052585004353 Yip1 domain; Region: Yip1; cl12048 1052585004354 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1052585004355 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1052585004356 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1052585004357 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052585004358 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1052585004359 Walker A/P-loop; other site 1052585004360 ATP binding site [chemical binding]; other site 1052585004361 Q-loop/lid; other site 1052585004362 ABC transporter signature motif; other site 1052585004363 Walker B; other site 1052585004364 D-loop; other site 1052585004365 H-loop/switch region; other site 1052585004366 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1052585004367 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1052585004368 FtsX-like permease family; Region: FtsX; cl15850 1052585004369 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1052585004370 Helix-turn-helix domains; Region: HTH; cl00088 1052585004371 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1052585004372 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1052585004373 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1052585004374 putative substrate binding site [chemical binding]; other site 1052585004375 putative ATP binding site [chemical binding]; other site 1052585004376 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1052585004377 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1052585004378 active site 1052585004379 phosphorylation site [posttranslational modification] 1052585004380 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1052585004381 P-loop; other site 1052585004382 active site 1052585004383 phosphorylation site [posttranslational modification] 1052585004384 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1052585004385 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1052585004386 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1052585004387 Catalytic site [active] 1052585004388 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1052585004389 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1052585004390 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1052585004391 ABC transporter; Region: ABC_tran_2; pfam12848 1052585004392 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 1052585004393 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1052585004394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585004395 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1052585004396 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1052585004397 rod-share determining protein MreBH; Provisional; Region: PRK13929 1052585004398 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 1052585004399 ATP binding site [chemical binding]; other site 1052585004400 profilin binding site; other site 1052585004401 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1052585004402 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1052585004403 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052585004404 putative active site [active] 1052585004405 heme pocket [chemical binding]; other site 1052585004406 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052585004407 dimer interface [polypeptide binding]; other site 1052585004408 phosphorylation site [posttranslational modification] 1052585004409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585004410 ATP binding site [chemical binding]; other site 1052585004411 Mg2+ binding site [ion binding]; other site 1052585004412 G-X-G motif; other site 1052585004413 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1052585004414 putative active site pocket [active] 1052585004415 dimerization interface [polypeptide binding]; other site 1052585004416 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1052585004417 putative active site pocket [active] 1052585004418 dimerization interface [polypeptide binding]; other site 1052585004419 putative catalytic residue [active] 1052585004420 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1052585004421 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585004422 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1052585004423 adenine deaminase; Region: ade; TIGR01178 1052585004424 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1052585004425 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1052585004426 active site 1052585004427 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1052585004428 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1052585004429 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052585004430 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1052585004431 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 1052585004432 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585004433 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1052585004434 active site 1052585004435 motif I; other site 1052585004436 motif II; other site 1052585004437 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1052585004438 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1052585004439 active site 1052585004440 catalytic residues [active] 1052585004441 metal binding site [ion binding]; metal-binding site 1052585004442 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 1052585004443 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1052585004444 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1052585004445 TPP-binding site [chemical binding]; other site 1052585004446 tetramer interface [polypeptide binding]; other site 1052585004447 heterodimer interface [polypeptide binding]; other site 1052585004448 phosphorylation loop region [posttranslational modification] 1052585004449 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1052585004450 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1052585004451 alpha subunit interface [polypeptide binding]; other site 1052585004452 TPP binding site [chemical binding]; other site 1052585004453 heterodimer interface [polypeptide binding]; other site 1052585004454 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1052585004455 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1052585004456 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1052585004457 E3 interaction surface; other site 1052585004458 lipoyl attachment site [posttranslational modification]; other site 1052585004459 e3 binding domain; Region: E3_binding; pfam02817 1052585004460 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 1052585004461 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1052585004462 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585004463 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052585004464 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1052585004465 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 1052585004466 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1052585004467 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1052585004468 homodimer interface [polypeptide binding]; other site 1052585004469 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585004470 catalytic residue [active] 1052585004471 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1052585004472 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 1052585004473 Protein of unknown function (DUF1054); Region: DUF1054; cl11544 1052585004474 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1052585004475 active site 1052585004476 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052585004477 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1052585004478 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1052585004479 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1052585004480 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 1052585004481 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1052585004482 active site 1052585004483 Zn binding site [ion binding]; other site 1052585004484 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052585004485 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 1052585004486 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052585004487 DNA binding residues [nucleotide binding] 1052585004488 Predicted integral membrane protein [Function unknown]; Region: COG5660 1052585004489 Putative zinc-finger; Region: zf-HC2; cl15806 1052585004490 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1052585004491 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1052585004492 G1 box; other site 1052585004493 putative GEF interaction site [polypeptide binding]; other site 1052585004494 GTP/Mg2+ binding site [chemical binding]; other site 1052585004495 Switch I region; other site 1052585004496 G2 box; other site 1052585004497 G3 box; other site 1052585004498 Switch II region; other site 1052585004499 G4 box; other site 1052585004500 G5 box; other site 1052585004501 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1052585004502 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1052585004503 YlaH-like protein; Region: YlaH; pfam14036 1052585004504 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; cl11558 1052585004505 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1052585004506 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1052585004507 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1052585004508 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1052585004509 putative active site [active] 1052585004510 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585004511 Glutaminase; Region: Glutaminase; cl00907 1052585004512 Protein of unknown function (DUF1507); Region: DUF1507; cl11487 1052585004513 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1052585004514 pyruvate carboxylase; Reviewed; Region: PRK12999 1052585004515 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052585004516 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1052585004517 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1052585004518 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1052585004519 active site 1052585004520 catalytic residues [active] 1052585004521 metal binding site [ion binding]; metal-binding site 1052585004522 homodimer binding site [polypeptide binding]; other site 1052585004523 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1052585004524 carboxyltransferase (CT) interaction site; other site 1052585004525 biotinylation site [posttranslational modification]; other site 1052585004526 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1052585004527 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 1052585004528 UbiA prenyltransferase family; Region: UbiA; cl00337 1052585004529 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1052585004530 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 1052585004531 Cytochrome c; Region: Cytochrom_C; cl11414 1052585004532 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1052585004533 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1052585004534 D-pathway; other site 1052585004535 Putative ubiquinol binding site [chemical binding]; other site 1052585004536 Low-spin heme (heme b) binding site [chemical binding]; other site 1052585004537 Putative water exit pathway; other site 1052585004538 Binuclear center (heme o3/CuB) [ion binding]; other site 1052585004539 K-pathway; other site 1052585004540 Putative proton exit pathway; other site 1052585004541 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1052585004542 Subunit I/III interface [polypeptide binding]; other site 1052585004543 Subunit III/IV interface [polypeptide binding]; other site 1052585004544 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 1052585004545 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 1052585004546 YugN-like family; Region: YugN; pfam08868 1052585004547 FOG: CBS domain [General function prediction only]; Region: COG0517 1052585004548 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1052585004549 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1052585004550 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1052585004551 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1052585004552 Putative coat protein; Region: YlbD_coat; pfam14071 1052585004553 YlbE-like protein; Region: YlbE; pfam14003 1052585004554 Protein of unknown function (DUF964); Region: DUF964; cl01483 1052585004555 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 1052585004556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585004557 S-adenosylmethionine binding site [chemical binding]; other site 1052585004558 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1052585004559 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1052585004560 active site 1052585004561 (T/H)XGH motif; other site 1052585004562 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 1052585004563 Nucleoside recognition; Region: Gate; cl00486 1052585004564 Nucleoside recognition; Region: Gate; cl00486 1052585004565 hypothetical protein; Provisional; Region: PRK10279 1052585004566 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1052585004567 nucleophile elbow; other site 1052585004568 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1052585004569 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1052585004570 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 1052585004571 protein binding site [polypeptide binding]; other site 1052585004572 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1052585004573 hypothetical protein; Provisional; Region: PRK13670 1052585004574 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1052585004575 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 1052585004576 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1052585004577 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1052585004578 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585004579 Coenzyme A binding pocket [chemical binding]; other site 1052585004580 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1052585004581 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585004582 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1052585004583 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1052585004584 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 1052585004585 mraZ protein; Region: TIGR00242 1052585004586 MraZ protein; Region: MraZ; pfam02381 1052585004587 MraZ protein; Region: MraZ; pfam02381 1052585004588 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1052585004589 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585004590 Septum formation initiator; Region: DivIC; cl11433 1052585004591 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1052585004592 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1052585004593 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052585004594 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1052585004595 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1052585004596 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 1052585004597 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1052585004598 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052585004599 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 1052585004600 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1052585004601 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1052585004602 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1052585004603 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1052585004604 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 1052585004605 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1052585004606 Mg++ binding site [ion binding]; other site 1052585004607 putative catalytic motif [active] 1052585004608 putative substrate binding site [chemical binding]; other site 1052585004609 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1052585004610 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1052585004611 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1052585004612 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1052585004613 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1052585004614 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1052585004615 active site 1052585004616 homodimer interface [polypeptide binding]; other site 1052585004617 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1052585004618 FAD binding domain; Region: FAD_binding_4; pfam01565 1052585004619 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1052585004620 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1052585004621 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1052585004622 Cell division protein FtsQ; Region: FtsQ; pfam03799 1052585004623 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1052585004624 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1052585004625 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1052585004626 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1052585004627 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 1052585004628 cell division protein FtsA; Region: ftsA; TIGR01174 1052585004629 Cell division protein FtsA; Region: FtsA; cl11496 1052585004630 Cell division protein FtsA; Region: FtsA; cl11496 1052585004631 cell division protein FtsZ; Validated; Region: PRK09330 1052585004632 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1052585004633 nucleotide binding site [chemical binding]; other site 1052585004634 SulA interaction site; other site 1052585004635 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1052585004636 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 1052585004637 active site 1052585004638 catalytic triad [active] 1052585004639 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 1052585004640 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1052585004641 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1052585004642 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1052585004643 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1052585004644 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 1052585004645 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 1052585004646 sporulation sigma factor SigE; Reviewed; Region: PRK08301 1052585004647 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052585004648 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052585004649 DNA binding residues [nucleotide binding] 1052585004650 sporulation sigma factor SigG; Reviewed; Region: PRK08215 1052585004651 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052585004652 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1052585004653 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052585004654 DNA binding residues [nucleotide binding] 1052585004655 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1052585004656 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 1052585004657 Walker A/P-loop; other site 1052585004658 ATP binding site [chemical binding]; other site 1052585004659 Q-loop/lid; other site 1052585004660 ABC transporter signature motif; other site 1052585004661 Walker B; other site 1052585004662 D-loop; other site 1052585004663 H-loop/switch region; other site 1052585004664 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 1052585004665 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1052585004666 metal binding site [ion binding]; metal-binding site 1052585004667 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 1052585004668 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1052585004669 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1052585004670 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1052585004671 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1052585004672 catalytic residue [active] 1052585004673 Protein of unknown function (DUF552); Region: DUF552; cl00775 1052585004674 YGGT family; Region: YGGT; cl00508 1052585004675 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1052585004676 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052585004677 RNA binding surface [nucleotide binding]; other site 1052585004678 DivIVA protein; Region: DivIVA; pfam05103 1052585004679 DivIVA domain; Region: DivI1A_domain; TIGR03544 1052585004680 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1052585004681 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1052585004682 HIGH motif; other site 1052585004683 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1052585004684 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1052585004685 active site 1052585004686 KMSKS motif; other site 1052585004687 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1052585004688 tRNA binding surface [nucleotide binding]; other site 1052585004689 anticodon binding site; other site 1052585004690 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1052585004691 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1052585004692 lipoprotein signal peptidase; Provisional; Region: PRK14787 1052585004693 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1052585004694 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052585004695 RNA binding surface [nucleotide binding]; other site 1052585004696 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 1052585004697 active site 1052585004698 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052585004699 active site 1052585004700 uracil-xanthine permease; Region: ncs2; TIGR00801 1052585004701 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1052585004702 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1052585004703 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1052585004704 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585004705 dihydroorotase; Validated; Region: pyrC; PRK09357 1052585004706 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1052585004707 active site 1052585004708 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1052585004709 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 1052585004710 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1052585004711 catalytic site [active] 1052585004712 subunit interface [polypeptide binding]; other site 1052585004713 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1052585004714 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052585004715 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1052585004716 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1052585004717 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052585004718 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1052585004719 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1052585004720 IMP binding site; other site 1052585004721 dimer interface [polypeptide binding]; other site 1052585004722 interdomain contacts; other site 1052585004723 partial ornithine binding site; other site 1052585004724 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1052585004725 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1052585004726 FAD binding pocket [chemical binding]; other site 1052585004727 FAD binding motif [chemical binding]; other site 1052585004728 phosphate binding motif [ion binding]; other site 1052585004729 beta-alpha-beta structure motif; other site 1052585004730 NAD binding pocket [chemical binding]; other site 1052585004731 Iron coordination center [ion binding]; other site 1052585004732 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1052585004733 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1052585004734 heterodimer interface [polypeptide binding]; other site 1052585004735 active site 1052585004736 FMN binding site [chemical binding]; other site 1052585004737 homodimer interface [polypeptide binding]; other site 1052585004738 substrate binding site [chemical binding]; other site 1052585004739 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 1052585004740 active site 1052585004741 dimer interface [polypeptide binding]; other site 1052585004742 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 1052585004743 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052585004744 active site 1052585004745 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1052585004746 Active Sites [active] 1052585004747 Phosphate transporter family; Region: PHO4; cl00396 1052585004748 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1052585004749 ATP-sulfurylase; Region: ATPS; cd00517 1052585004750 active site 1052585004751 HXXH motif; other site 1052585004752 flexible loop; other site 1052585004753 AAA domain; Region: AAA_33; pfam13671 1052585004754 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 1052585004755 ligand-binding site [chemical binding]; other site 1052585004756 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 1052585004757 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 1052585004758 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1052585004759 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1052585004760 putative active site [active] 1052585004761 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1052585004762 putative active site [active] 1052585004763 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585004764 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1052585004765 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1052585004766 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1052585004767 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 1052585004768 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1052585004769 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1052585004770 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585004771 motif II; other site 1052585004772 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1052585004773 TIGR00255 family protein; Region: TIGR00255 1052585004774 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1052585004775 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1052585004776 Domain of unknown function (DUF370); Region: DUF370; cl00898 1052585004777 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1052585004778 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1052585004779 catalytic site [active] 1052585004780 G-X2-G-X-G-K; other site 1052585004781 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 1052585004782 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1052585004783 Flavoprotein; Region: Flavoprotein; cl08021 1052585004784 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 1052585004785 primosome assembly protein PriA; Validated; Region: PRK05580 1052585004786 primosome assembly protein PriA; Validated; Region: PRK05580 1052585004787 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052585004788 ATP binding site [chemical binding]; other site 1052585004789 putative Mg++ binding site [ion binding]; other site 1052585004790 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052585004791 nucleotide binding region [chemical binding]; other site 1052585004792 ATP-binding site [chemical binding]; other site 1052585004793 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1052585004794 active site 1052585004795 catalytic residues [active] 1052585004796 metal binding site [ion binding]; metal-binding site 1052585004797 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1052585004798 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1052585004799 putative active site [active] 1052585004800 substrate binding site [chemical binding]; other site 1052585004801 putative cosubstrate binding site; other site 1052585004802 catalytic site [active] 1052585004803 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1052585004804 substrate binding site [chemical binding]; other site 1052585004805 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1052585004806 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1052585004807 putative RNA binding site [nucleotide binding]; other site 1052585004808 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585004809 S-adenosylmethionine binding site [chemical binding]; other site 1052585004810 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1052585004811 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052585004812 FeS/SAM binding site; other site 1052585004813 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1052585004814 Protein phosphatase 2C; Region: PP2C; pfam00481 1052585004815 active site 1052585004816 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052585004817 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1052585004818 active site 1052585004819 ATP binding site [chemical binding]; other site 1052585004820 substrate binding site [chemical binding]; other site 1052585004821 activation loop (A-loop); other site 1052585004822 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1052585004823 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1052585004824 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1052585004825 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1052585004826 GTPase RsgA; Reviewed; Region: PRK00098 1052585004827 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1052585004828 RNA binding site [nucleotide binding]; other site 1052585004829 homodimer interface [polypeptide binding]; other site 1052585004830 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1052585004831 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1052585004832 GTP/Mg2+ binding site [chemical binding]; other site 1052585004833 G4 box; other site 1052585004834 G5 box; other site 1052585004835 G1 box; other site 1052585004836 Switch I region; other site 1052585004837 G2 box; other site 1052585004838 G3 box; other site 1052585004839 Switch II region; other site 1052585004840 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1052585004841 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1052585004842 substrate binding site [chemical binding]; other site 1052585004843 hexamer interface [polypeptide binding]; other site 1052585004844 metal binding site [ion binding]; metal-binding site 1052585004845 Thiamine pyrophosphokinase; Region: TPK; cd07995 1052585004846 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1052585004847 active site 1052585004848 dimerization interface [polypeptide binding]; other site 1052585004849 thiamine binding site [chemical binding]; other site 1052585004850 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 1052585004851 Asp23 family; Region: Asp23; cl00574 1052585004852 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1052585004853 DAK2 domain; Region: Dak2; cl03685 1052585004854 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 1052585004855 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1052585004856 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1052585004857 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 1052585004858 putative L-serine binding site [chemical binding]; other site 1052585004859 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1052585004860 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1052585004861 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1052585004862 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1052585004863 generic binding surface II; other site 1052585004864 ssDNA binding site; other site 1052585004865 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052585004866 ATP binding site [chemical binding]; other site 1052585004867 putative Mg++ binding site [ion binding]; other site 1052585004868 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052585004869 nucleotide binding region [chemical binding]; other site 1052585004870 ATP-binding site [chemical binding]; other site 1052585004871 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1052585004872 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1052585004873 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 1052585004874 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1052585004875 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1052585004876 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1052585004877 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1052585004878 NAD(P) binding site [chemical binding]; other site 1052585004879 homotetramer interface [polypeptide binding]; other site 1052585004880 homodimer interface [polypeptide binding]; other site 1052585004881 active site 1052585004882 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585004883 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 1052585004884 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1052585004885 dimerization interface [polypeptide binding]; other site 1052585004886 active site 1052585004887 metal binding site [ion binding]; metal-binding site 1052585004888 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1052585004889 dsRNA binding site [nucleotide binding]; other site 1052585004890 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1052585004891 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 1052585004892 Walker A/P-loop; other site 1052585004893 ATP binding site [chemical binding]; other site 1052585004894 Q-loop/lid; other site 1052585004895 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 1052585004896 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 1052585004897 ABC transporter signature motif; other site 1052585004898 Walker B; other site 1052585004899 D-loop; other site 1052585004900 H-loop/switch region; other site 1052585004901 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1052585004902 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 1052585004903 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1052585004904 GTP binding site [chemical binding]; other site 1052585004905 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1052585004906 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1052585004907 signal recognition particle protein; Provisional; Region: PRK10867 1052585004908 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 1052585004909 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1052585004910 P loop; other site 1052585004911 GTP binding site [chemical binding]; other site 1052585004912 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1052585004913 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 1052585004914 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1052585004915 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 1052585004916 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 1052585004917 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1052585004918 RimM N-terminal domain; Region: RimM; pfam01782 1052585004919 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 1052585004920 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 1052585004921 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 1052585004922 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1052585004923 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1052585004924 GTP/Mg2+ binding site [chemical binding]; other site 1052585004925 G4 box; other site 1052585004926 G5 box; other site 1052585004927 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1052585004928 G1 box; other site 1052585004929 G1 box; other site 1052585004930 GTP/Mg2+ binding site [chemical binding]; other site 1052585004931 Switch I region; other site 1052585004932 G2 box; other site 1052585004933 G2 box; other site 1052585004934 G3 box; other site 1052585004935 G3 box; other site 1052585004936 Switch II region; other site 1052585004937 Switch II region; other site 1052585004938 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1052585004939 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1052585004940 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1052585004941 CoA-ligase; Region: Ligase_CoA; cl02894 1052585004942 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1052585004943 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585004944 CoA-ligase; Region: Ligase_CoA; cl02894 1052585004945 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1052585004946 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1052585004947 DNA topoisomerase I; Validated; Region: PRK05582 1052585004948 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1052585004949 active site 1052585004950 interdomain interaction site; other site 1052585004951 putative metal-binding site [ion binding]; other site 1052585004952 nucleotide binding site [chemical binding]; other site 1052585004953 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1052585004954 domain I; other site 1052585004955 DNA binding groove [nucleotide binding] 1052585004956 phosphate binding site [ion binding]; other site 1052585004957 domain II; other site 1052585004958 domain III; other site 1052585004959 nucleotide binding site [chemical binding]; other site 1052585004960 catalytic site [active] 1052585004961 domain IV; other site 1052585004962 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1052585004963 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1052585004964 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1052585004965 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585004966 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1052585004967 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1052585004968 Int/Topo IB signature motif; other site 1052585004969 active site 1052585004970 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1052585004971 active site 1052585004972 HslU subunit interaction site [polypeptide binding]; other site 1052585004973 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1052585004974 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585004975 Walker A motif; other site 1052585004976 ATP binding site [chemical binding]; other site 1052585004977 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585004978 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1052585004979 transcriptional repressor CodY; Validated; Region: PRK04158 1052585004980 CodY GAF-like domain; Region: CodY; pfam06018 1052585004981 Helix-turn-helix domains; Region: HTH; cl00088 1052585004982 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1052585004983 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 1052585004984 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1052585004985 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 1052585004986 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1052585004987 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 1052585004988 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 1052585004989 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1052585004990 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1052585004991 flagellar motor switch protein FliG; Region: fliG; TIGR00207 1052585004992 MgtE intracellular N domain; Region: MgtE_N; cl15244 1052585004993 FliG C-terminal domain; Region: FliG_C; pfam01706 1052585004994 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 1052585004995 Plant ATP synthase F0; Region: YMF19; cl07975 1052585004996 Flagellar assembly protein FliH; Region: FliH; pfam02108 1052585004997 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 1052585004998 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 1052585004999 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1052585005000 Walker A motif/ATP binding site; other site 1052585005001 Walker B motif; other site 1052585005002 flagellar biosynthesis chaperone; Validated; Region: fliJ; cl09161 1052585005003 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 1052585005004 MgtE intracellular N domain; Region: MgtE_N; cl15244 1052585005005 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 1052585005006 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 1052585005007 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 1052585005008 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1052585005009 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 1052585005010 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 1052585005011 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1052585005012 Flagellar protein (FlbD); Region: FlbD; cl00683 1052585005013 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 1052585005014 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1052585005015 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1052585005016 flagellar motor switch protein; Validated; Region: PRK08119 1052585005017 Chemotaxis phosphatase CheX; Region: CheX; cl15816 1052585005018 Chemotaxis phosphatase CheX; Region: CheX; cl15816 1052585005019 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1052585005020 Response regulator receiver domain; Region: Response_reg; pfam00072 1052585005021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585005022 active site 1052585005023 phosphorylation site [posttranslational modification] 1052585005024 intermolecular recognition site; other site 1052585005025 dimerization interface [polypeptide binding]; other site 1052585005026 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 1052585005027 FliP family; Region: FliP; cl00593 1052585005028 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 1052585005029 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 1052585005030 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1052585005031 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1052585005032 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 1052585005033 FHIPEP family; Region: FHIPEP; pfam00771 1052585005034 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1052585005035 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585005036 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1052585005037 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1052585005038 P-loop; other site 1052585005039 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1052585005040 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1052585005041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585005042 active site 1052585005043 phosphorylation site [posttranslational modification] 1052585005044 intermolecular recognition site; other site 1052585005045 dimerization interface [polypeptide binding]; other site 1052585005046 CheB methylesterase; Region: CheB_methylest; pfam01339 1052585005047 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1052585005048 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1052585005049 putative binding surface; other site 1052585005050 active site 1052585005051 P2 response regulator binding domain; Region: P2; pfam07194 1052585005052 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1052585005053 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585005054 ATP binding site [chemical binding]; other site 1052585005055 Mg2+ binding site [ion binding]; other site 1052585005056 G-X-G motif; other site 1052585005057 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1052585005058 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1052585005059 putative CheA interaction surface; other site 1052585005060 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1052585005061 Chemotaxis phosphatase CheX; Region: CheX; cl15816 1052585005062 Chemotaxis phosphatase CheX; Region: CheX; cl15816 1052585005063 CheD chemotactic sensory transduction; Region: CheD; cl00810 1052585005064 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 1052585005065 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052585005066 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1052585005067 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052585005068 DNA binding residues [nucleotide binding] 1052585005069 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1052585005070 rRNA interaction site [nucleotide binding]; other site 1052585005071 S8 interaction site; other site 1052585005072 putative laminin-1 binding site; other site 1052585005073 elongation factor Ts; Provisional; Region: tsf; PRK09377 1052585005074 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 1052585005075 Elongation factor TS; Region: EF_TS; pfam00889 1052585005076 Elongation factor TS; Region: EF_TS; pfam00889 1052585005077 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1052585005078 putative nucleotide binding site [chemical binding]; other site 1052585005079 uridine monophosphate binding site [chemical binding]; other site 1052585005080 homohexameric interface [polypeptide binding]; other site 1052585005081 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1052585005082 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 1052585005083 hinge region; other site 1052585005084 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1052585005085 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1052585005086 catalytic residue [active] 1052585005087 putative FPP diphosphate binding site; other site 1052585005088 putative FPP binding hydrophobic cleft; other site 1052585005089 dimer interface [polypeptide binding]; other site 1052585005090 putative IPP diphosphate binding site; other site 1052585005091 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 1052585005092 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1052585005093 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1052585005094 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1052585005095 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1052585005096 RIP metalloprotease RseP; Region: TIGR00054 1052585005097 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1052585005098 active site 1052585005099 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1052585005100 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1052585005101 protein binding site [polypeptide binding]; other site 1052585005102 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1052585005103 putative substrate binding region [chemical binding]; other site 1052585005104 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1052585005105 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 1052585005106 dimer interface [polypeptide binding]; other site 1052585005107 motif 1; other site 1052585005108 active site 1052585005109 motif 2; other site 1052585005110 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1052585005111 putative deacylase active site [active] 1052585005112 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 1052585005113 active site 1052585005114 motif 3; other site 1052585005115 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1052585005116 anticodon binding site; other site 1052585005117 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1052585005118 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1052585005119 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1052585005120 generic binding surface II; other site 1052585005121 generic binding surface I; other site 1052585005122 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1052585005123 active site 1052585005124 substrate binding site [chemical binding]; other site 1052585005125 catalytic site [active] 1052585005126 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 1052585005127 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1052585005128 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 1052585005129 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 1052585005130 Sm1 motif; other site 1052585005131 predicted subunit interaction site [polypeptide binding]; other site 1052585005132 RNA binding pocket [nucleotide binding]; other site 1052585005133 Sm2 motif; other site 1052585005134 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1052585005135 NusA N-terminal domain; Region: NusA_N; pfam08529 1052585005136 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1052585005137 RNA binding site [nucleotide binding]; other site 1052585005138 homodimer interface [polypeptide binding]; other site 1052585005139 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 1052585005140 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1052585005141 G-X-X-G motif; other site 1052585005142 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1052585005143 putative RNA binding cleft [nucleotide binding]; other site 1052585005144 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1052585005145 Translation-initiation factor 2; Region: IF-2; pfam11987 1052585005146 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1052585005147 Protein of unknown function (DUF503); Region: DUF503; cl00669 1052585005148 Ribosome-binding factor A; Region: RBFA; cl00542 1052585005149 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1052585005150 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 1052585005151 RNA binding site [nucleotide binding]; other site 1052585005152 active site 1052585005153 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1052585005154 riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083 1052585005155 active site 1052585005156 Riboflavin kinase; Region: Flavokinase; cl03312 1052585005157 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1052585005158 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1052585005159 RNase E interface [polypeptide binding]; other site 1052585005160 trimer interface [polypeptide binding]; other site 1052585005161 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1052585005162 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1052585005163 RNase E interface [polypeptide binding]; other site 1052585005164 trimer interface [polypeptide binding]; other site 1052585005165 active site 1052585005166 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1052585005167 putative nucleic acid binding region [nucleotide binding]; other site 1052585005168 G-X-X-G motif; other site 1052585005169 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1052585005170 RNA binding site [nucleotide binding]; other site 1052585005171 domain interface; other site 1052585005172 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 1052585005173 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 1052585005174 NodB motif; other site 1052585005175 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1052585005176 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1052585005177 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1052585005178 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 1052585005179 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 1052585005180 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585005181 Flavoprotein; Region: Flavoprotein; cl08021 1052585005182 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1052585005183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585005184 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1052585005185 aspartate kinase I; Reviewed; Region: PRK08210 1052585005186 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 1052585005187 putative catalytic residues [active] 1052585005188 putative nucleotide binding site [chemical binding]; other site 1052585005189 putative aspartate binding site [chemical binding]; other site 1052585005190 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 1052585005191 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 1052585005192 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1052585005193 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1052585005194 dimer interface [polypeptide binding]; other site 1052585005195 active site 1052585005196 catalytic residue [active] 1052585005197 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1052585005198 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052585005199 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1052585005200 Clp protease; Region: CLP_protease; pfam00574 1052585005201 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1052585005202 active site 1052585005203 YlzJ-like protein; Region: YlzJ; pfam14035 1052585005204 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1052585005205 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1052585005206 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585005207 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 1052585005208 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1052585005209 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585005210 DNA-binding site [nucleotide binding]; DNA binding site 1052585005211 UTRA domain; Region: UTRA; cl01230 1052585005212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585005213 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585005214 putative substrate translocation pore; other site 1052585005215 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1052585005216 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1052585005217 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1052585005218 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1052585005219 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1052585005220 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1052585005221 classical (c) SDRs; Region: SDR_c; cd05233 1052585005222 NAD(P) binding site [chemical binding]; other site 1052585005223 active site 1052585005224 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1052585005225 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1052585005226 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1052585005227 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1052585005228 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1052585005229 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1052585005230 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1052585005231 competence damage-inducible protein A; Provisional; Region: PRK00549 1052585005232 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1052585005233 putative MPT binding site; other site 1052585005234 Competence-damaged protein; Region: CinA; cl00666 1052585005235 recombinase A; Provisional; Region: recA; PRK09354 1052585005236 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1052585005237 hexamer interface [polypeptide binding]; other site 1052585005238 Walker A motif; other site 1052585005239 ATP binding site [chemical binding]; other site 1052585005240 Walker B motif; other site 1052585005241 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052585005242 phosphodiesterase; Provisional; Region: PRK12704 1052585005243 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1052585005244 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1052585005245 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1052585005246 putative active site [active] 1052585005247 metal binding site [ion binding]; metal-binding site 1052585005248 homodimer binding site [polypeptide binding]; other site 1052585005249 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 1052585005250 Threonine dehydrogenase; Region: TDH; cd05281 1052585005251 L-threonine 3-dehydrogenase; Region: tdh; TIGR00692 1052585005252 structural Zn binding site [ion binding]; other site 1052585005253 catalytic Zn binding site [ion binding]; other site 1052585005254 tetramer interface [polypeptide binding]; other site 1052585005255 NADP binding site [chemical binding]; other site 1052585005256 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1052585005257 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1052585005258 substrate-cofactor binding pocket; other site 1052585005259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585005260 catalytic residue [active] 1052585005261 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 1052585005262 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1052585005263 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052585005264 FeS/SAM binding site; other site 1052585005265 TRAM domain; Region: TRAM; cl01282 1052585005266 Protein of unknown function (DUF964); Region: DUF964; cl01483 1052585005267 Outer spore coat protein E (CotE); Region: CotE; pfam10628 1052585005268 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1052585005269 MutS domain I; Region: MutS_I; pfam01624 1052585005270 MutS domain II; Region: MutS_II; pfam05188 1052585005271 MutS family domain IV; Region: MutS_IV; pfam05190 1052585005272 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 1052585005273 Walker A/P-loop; other site 1052585005274 ATP binding site [chemical binding]; other site 1052585005275 Q-loop/lid; other site 1052585005276 ABC transporter signature motif; other site 1052585005277 Walker B; other site 1052585005278 D-loop; other site 1052585005279 H-loop/switch region; other site 1052585005280 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1052585005281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585005282 ATP binding site [chemical binding]; other site 1052585005283 Mg2+ binding site [ion binding]; other site 1052585005284 G-X-G motif; other site 1052585005285 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1052585005286 ATP binding site [chemical binding]; other site 1052585005287 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 1052585005288 Regulatory protein YrvL; Region: YrvL; pfam14184 1052585005289 transcriptional regulator BetI; Validated; Region: PRK00767 1052585005290 Helix-turn-helix domains; Region: HTH; cl00088 1052585005291 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 1052585005292 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052585005293 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1052585005294 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1052585005295 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1052585005296 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1052585005297 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1052585005298 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1052585005299 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1052585005300 FMN binding site [chemical binding]; other site 1052585005301 substrate binding site [chemical binding]; other site 1052585005302 putative catalytic residue [active] 1052585005303 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585005304 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 1052585005305 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1052585005306 dimer interface [polypeptide binding]; other site 1052585005307 active site 1052585005308 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 1052585005309 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827 1052585005310 dimer interface [polypeptide binding]; other site 1052585005311 active site 1052585005312 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1052585005313 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1052585005314 substrate binding site [chemical binding]; other site 1052585005315 oxyanion hole (OAH) forming residues; other site 1052585005316 trimer interface [polypeptide binding]; other site 1052585005317 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1052585005318 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1052585005319 substrate binding site [chemical binding]; other site 1052585005320 oxyanion hole (OAH) forming residues; other site 1052585005321 trimer interface [polypeptide binding]; other site 1052585005322 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1052585005323 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585005324 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585005325 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585005326 Condensation domain; Region: Condensation; pfam00668 1052585005327 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052585005328 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052585005329 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585005330 acyl-CoA synthetase; Validated; Region: PRK08308 1052585005331 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585005332 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052585005333 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052585005334 active site 1052585005335 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052585005336 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052585005337 putative NADP binding site [chemical binding]; other site 1052585005338 active site 1052585005339 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585005340 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585005341 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052585005342 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052585005343 active site 1052585005344 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052585005345 putative NADP binding site [chemical binding]; other site 1052585005346 active site 1052585005347 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585005348 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052585005349 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052585005350 active site 1052585005351 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052585005352 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585005353 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052585005354 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052585005355 active site 1052585005356 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052585005357 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052585005358 putative NADP binding site [chemical binding]; other site 1052585005359 active site 1052585005360 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585005361 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052585005362 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052585005363 active site 1052585005364 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585005365 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585005366 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052585005367 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052585005368 active site 1052585005369 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052585005370 putative NADP binding site [chemical binding]; other site 1052585005371 active site 1052585005372 peptide synthase; Provisional; Region: PRK12316 1052585005373 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585005374 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052585005375 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052585005376 active site 1052585005377 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585005378 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052585005379 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052585005380 active site 1052585005381 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052585005382 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052585005383 putative NADP binding site [chemical binding]; other site 1052585005384 active site 1052585005385 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585005386 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585005387 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585005388 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052585005389 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052585005390 active site 1052585005391 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052585005392 putative NADP binding site [chemical binding]; other site 1052585005393 active site 1052585005394 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585005395 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052585005396 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052585005397 active site 1052585005398 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585005399 Condensation domain; Region: Condensation; pfam00668 1052585005400 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052585005401 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052585005402 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585005403 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585005404 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585005405 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052585005406 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052585005407 active site 1052585005408 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052585005409 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052585005410 putative NADP binding site [chemical binding]; other site 1052585005411 active site 1052585005412 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585005413 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052585005414 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052585005415 active site 1052585005416 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052585005417 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052585005418 putative NADP binding site [chemical binding]; other site 1052585005419 active site 1052585005420 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585005421 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052585005422 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052585005423 active site 1052585005424 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052585005425 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052585005426 putative NADP binding site [chemical binding]; other site 1052585005427 active site 1052585005428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585005429 S-adenosylmethionine binding site [chemical binding]; other site 1052585005430 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585005431 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052585005432 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052585005433 active site 1052585005434 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585005435 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052585005436 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052585005437 active site 1052585005438 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585005439 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1052585005440 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1052585005441 Cytochrome P450; Region: p450; pfam00067 1052585005442 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052585005443 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 1052585005444 active site 1052585005445 catalytic triad [active] 1052585005446 Protein of unknown function (DUF867); Region: DUF867; cl01713 1052585005447 OsmC-like protein; Region: OsmC; cl00767 1052585005448 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1052585005449 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1052585005450 YmaF family; Region: YmaF; pfam12788 1052585005451 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585005452 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1052585005453 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 1052585005454 Sm1 motif; other site 1052585005455 intra - hexamer interaction site; other site 1052585005456 inter - hexamer interaction site [polypeptide binding]; other site 1052585005457 nucleotide binding pocket [chemical binding]; other site 1052585005458 Sm2 motif; other site 1052585005459 YmzC-like protein; Region: YmzC; pfam14157 1052585005460 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1052585005461 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1052585005462 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1052585005463 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1052585005464 active site 1052585005465 dimer interface [polypeptide binding]; other site 1052585005466 catalytic residues [active] 1052585005467 effector binding site; other site 1052585005468 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1052585005469 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1052585005470 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1052585005471 dimer interface [polypeptide binding]; other site 1052585005472 putative radical transfer pathway; other site 1052585005473 diiron center [ion binding]; other site 1052585005474 tyrosyl radical; other site 1052585005475 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1052585005476 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1052585005477 active site 1052585005478 metal binding site [ion binding]; metal-binding site 1052585005479 Sporulation related domain; Region: SPOR; cl10051 1052585005480 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1052585005481 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585005482 Walker A motif; other site 1052585005483 ATP binding site [chemical binding]; other site 1052585005484 Walker B motif; other site 1052585005485 arginine finger; other site 1052585005486 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1052585005487 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1052585005488 HflX GTPase family; Region: HflX; cd01878 1052585005489 G1 box; other site 1052585005490 GTP/Mg2+ binding site [chemical binding]; other site 1052585005491 Switch I region; other site 1052585005492 G2 box; other site 1052585005493 G3 box; other site 1052585005494 Switch II region; other site 1052585005495 G4 box; other site 1052585005496 G5 box; other site 1052585005497 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1052585005498 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1052585005499 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052585005500 catalytic residue [active] 1052585005501 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1052585005502 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1052585005503 DNA binding residues [nucleotide binding] 1052585005504 putative dimer interface [polypeptide binding]; other site 1052585005505 glutamine synthetase, type I; Region: GlnA; TIGR00653 1052585005506 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1052585005507 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1052585005508 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1052585005509 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1052585005510 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1052585005511 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1052585005512 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1052585005513 inhibitor binding site; inhibition site 1052585005514 active site 1052585005515 Helix-turn-helix domains; Region: HTH; cl00088 1052585005516 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1052585005517 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1052585005518 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 1052585005519 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1052585005520 N- and C-terminal domain interface [polypeptide binding]; other site 1052585005521 D-xylulose kinase; Region: XylB; TIGR01312 1052585005522 active site 1052585005523 catalytic site [active] 1052585005524 metal binding site [ion binding]; metal-binding site 1052585005525 xylulose binding site [chemical binding]; other site 1052585005526 putative ATP binding site [chemical binding]; other site 1052585005527 homodimer interface [polypeptide binding]; other site 1052585005528 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 1052585005529 Staphylococcal nuclease homologues; Region: SNc; smart00318 1052585005530 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1052585005531 Catalytic site; other site 1052585005532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585005533 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1052585005534 putative substrate translocation pore; other site 1052585005535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585005536 alanine racemase; Region: alr; TIGR00492 1052585005537 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1052585005538 active site 1052585005539 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1052585005540 dimer interface [polypeptide binding]; other site 1052585005541 substrate binding site [chemical binding]; other site 1052585005542 catalytic residues [active] 1052585005543 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 1052585005544 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1052585005545 trimer interface [polypeptide binding]; other site 1052585005546 active site 1052585005547 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1052585005548 dimerization interface [polypeptide binding]; other site 1052585005549 active site 1052585005550 YoqO-like protein; Region: YoqO; pfam14037 1052585005551 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1052585005552 putative hydrophobic ligand binding site [chemical binding]; other site 1052585005553 Chromate transporter; Region: Chromate_transp; pfam02417 1052585005554 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 1052585005555 Chromate transporter; Region: Chromate_transp; pfam02417 1052585005556 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1052585005557 Spore germination protein; Region: Spore_permease; cl15802 1052585005558 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 1052585005559 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 1052585005560 YndJ-like protein; Region: YndJ; pfam14158 1052585005561 Protein of unknown function (DUF1180); Region: DUF1180; pfam06679 1052585005562 Protein of unknown function (DUF867); Region: DUF867; cl01713 1052585005563 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1052585005564 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052585005565 FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363 1052585005566 putative active site [active] 1052585005567 putative Mg binding site [ion binding]; other site 1052585005568 LexA repressor; Validated; Region: PRK00215 1052585005569 Helix-turn-helix domains; Region: HTH; cl00088 1052585005570 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1052585005571 Catalytic site [active] 1052585005572 cell division suppressor protein YneA; Provisional; Region: PRK14125 1052585005573 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 1052585005574 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1052585005575 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1052585005576 catalytic residues [active] 1052585005577 catalytic nucleophile [active] 1052585005578 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 1052585005579 transketolase, bacterial and yeast; Region: tktlase_bact; TIGR00232 1052585005580 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1052585005581 TPP-binding site [chemical binding]; other site 1052585005582 dimer interface [polypeptide binding]; other site 1052585005583 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1052585005584 PYR/PP interface [polypeptide binding]; other site 1052585005585 dimer interface [polypeptide binding]; other site 1052585005586 TPP binding site [chemical binding]; other site 1052585005587 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1052585005588 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 1052585005589 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 1052585005590 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1052585005591 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1052585005592 Response regulator receiver domain; Region: Response_reg; pfam00072 1052585005593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585005594 active site 1052585005595 phosphorylation site [posttranslational modification] 1052585005596 intermolecular recognition site; other site 1052585005597 dimerization interface [polypeptide binding]; other site 1052585005598 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 1052585005599 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 1052585005600 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1052585005601 putative dimer interface [polypeptide binding]; other site 1052585005602 Small acid-soluble spore protein P family; Region: SspP; cl12105 1052585005603 Small acid-soluble spore protein O family; Region: SspO; cl07943 1052585005604 aconitate hydratase; Validated; Region: PRK09277 1052585005605 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1052585005606 substrate binding site [chemical binding]; other site 1052585005607 ligand binding site [chemical binding]; other site 1052585005608 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1052585005609 substrate binding site [chemical binding]; other site 1052585005610 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 1052585005611 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1052585005612 catalytic residues [active] 1052585005613 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 1052585005614 Small acid-soluble spore protein N family; Region: SspN; cl11659 1052585005615 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830; cl07951 1052585005616 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1052585005617 active site 1052585005618 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1052585005619 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 1052585005620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585005621 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 1052585005622 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585005623 ATP binding site [chemical binding]; other site 1052585005624 Mg2+ binding site [ion binding]; other site 1052585005625 G-X-G motif; other site 1052585005626 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1052585005627 anchoring element; other site 1052585005628 dimer interface [polypeptide binding]; other site 1052585005629 ATP binding site [chemical binding]; other site 1052585005630 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1052585005631 active site 1052585005632 putative metal-binding site [ion binding]; other site 1052585005633 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1052585005634 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 1052585005635 active site 1052585005636 primary dimer interface [polypeptide binding]; other site 1052585005637 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052585005638 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052585005639 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052585005640 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052585005641 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1052585005642 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1052585005643 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1052585005644 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 1052585005645 Cellulose binding domain; Region: CBM_3; cl03026 1052585005646 GtrA-like protein; Region: GtrA; cl00971 1052585005647 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1052585005648 active site 1052585005649 tetramer interface; other site 1052585005650 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1052585005651 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 1052585005652 DHH family; Region: DHH; pfam01368 1052585005653 DHHA1 domain; Region: DHHA1; pfam02272 1052585005654 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1052585005655 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1052585005656 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1052585005657 enoyl-CoA hydratase; Provisional; Region: PRK07657 1052585005658 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1052585005659 substrate binding site [chemical binding]; other site 1052585005660 oxyanion hole (OAH) forming residues; other site 1052585005661 trimer interface [polypeptide binding]; other site 1052585005662 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1052585005663 active site 1052585005664 catalytic residues [active] 1052585005665 metal binding site [ion binding]; metal-binding site 1052585005666 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1052585005667 carboxyltransferase (CT) interaction site; other site 1052585005668 biotinylation site [posttranslational modification]; other site 1052585005669 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 1052585005670 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052585005671 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1052585005672 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1052585005673 AMP-binding domain protein; Validated; Region: PRK08315 1052585005674 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585005675 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052585005676 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1052585005677 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1052585005678 active site 1052585005679 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1052585005680 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052585005681 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 1052585005682 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1052585005683 peptide synthase; Provisional; Region: PRK12467 1052585005684 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585005685 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585005686 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052585005687 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585005688 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585005689 peptide synthase; Provisional; Region: PRK12467 1052585005690 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052585005691 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585005692 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585005693 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052585005694 peptide synthase; Provisional; Region: PRK12316 1052585005695 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585005696 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585005697 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052585005698 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585005699 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585005700 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052585005701 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585005702 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585005703 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052585005704 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052585005705 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1052585005706 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585005707 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585005708 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052585005709 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052585005710 active site 1052585005711 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052585005712 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585005713 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 1052585005714 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052585005715 inhibitor-cofactor binding pocket; inhibition site 1052585005716 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585005717 catalytic residue [active] 1052585005718 Condensation domain; Region: Condensation; pfam00668 1052585005719 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052585005720 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052585005721 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585005722 peptide synthase; Provisional; Region: PRK12467 1052585005723 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052585005724 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585005725 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585005726 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052585005727 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1052585005728 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1052585005729 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052585005730 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 1052585005731 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 1052585005732 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 1052585005733 active site 1052585005734 catalytic residues [active] 1052585005735 MatE; Region: MatE; cl10513 1052585005736 putative efflux protein, MATE family; Region: matE; TIGR00797 1052585005737 MatE; Region: MatE; cl10513 1052585005738 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 1052585005739 Int/Topo IB signature motif; other site 1052585005740 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1052585005741 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1052585005742 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1052585005743 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052585005744 Helix-turn-helix domains; Region: HTH; cl00088 1052585005745 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1052585005746 putative dimerization interface [polypeptide binding]; other site 1052585005747 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1052585005748 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585005749 NAD(P) binding site [chemical binding]; other site 1052585005750 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 1052585005751 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585005752 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1052585005753 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1052585005754 active site 1052585005755 dimer interface [polypeptide binding]; other site 1052585005756 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1052585005757 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1052585005758 active site 1052585005759 FMN binding site [chemical binding]; other site 1052585005760 substrate binding site [chemical binding]; other site 1052585005761 3Fe-4S cluster binding site [ion binding]; other site 1052585005762 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1052585005763 domain interface; other site 1052585005764 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052585005765 Helix-turn-helix domains; Region: HTH; cl00088 1052585005766 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1052585005767 putative dimerization interface [polypeptide binding]; other site 1052585005768 gamma-glutamyl kinase; Provisional; Region: PRK13402 1052585005769 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1052585005770 nucleotide binding site [chemical binding]; other site 1052585005771 homotetrameric interface [polypeptide binding]; other site 1052585005772 putative phosphate binding site [ion binding]; other site 1052585005773 putative allosteric binding site; other site 1052585005774 PUA domain; Region: PUA; cl00607 1052585005775 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585005776 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 1052585005777 Replication terminator protein; Region: RTP; pfam02334 1052585005778 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1052585005779 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1052585005780 classical (c) SDRs; Region: SDR_c; cd05233 1052585005781 NAD(P) binding site [chemical binding]; other site 1052585005782 active site 1052585005783 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 1052585005784 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1052585005785 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1052585005786 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052585005787 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585005788 Walker A/P-loop; other site 1052585005789 ATP binding site [chemical binding]; other site 1052585005790 Q-loop/lid; other site 1052585005791 ABC transporter signature motif; other site 1052585005792 Walker B; other site 1052585005793 D-loop; other site 1052585005794 H-loop/switch region; other site 1052585005795 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585005796 Helix-turn-helix domains; Region: HTH; cl00088 1052585005797 Helix-turn-helix domains; Region: HTH; cl00088 1052585005798 polyol permease family; Region: 2A0118; TIGR00897 1052585005799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585005800 putative substrate translocation pore; other site 1052585005801 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1052585005802 Autoinducer-2 kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K_like; cd07798 1052585005803 putative N- and C-terminal domain interface [polypeptide binding]; other site 1052585005804 putative active site [active] 1052585005805 putative MgATP binding site [chemical binding]; other site 1052585005806 catalytic site [active] 1052585005807 metal binding site [ion binding]; metal-binding site 1052585005808 carbohydrate binding site [chemical binding]; other site 1052585005809 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1052585005810 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585005811 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1052585005812 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1052585005813 putative [4Fe-4S] binding site [ion binding]; other site 1052585005814 putative molybdopterin cofactor binding site [chemical binding]; other site 1052585005815 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 1052585005816 putative molybdopterin cofactor binding site; other site 1052585005817 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 1052585005818 CHASE3 domain; Region: CHASE3; cl05000 1052585005819 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052585005820 dimerization interface [polypeptide binding]; other site 1052585005821 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052585005822 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052585005823 dimer interface [polypeptide binding]; other site 1052585005824 putative CheW interface [polypeptide binding]; other site 1052585005825 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 1052585005826 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1052585005827 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 1052585005828 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 1052585005829 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 1052585005830 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1052585005831 Pectate lyase; Region: Pec_lyase_C; cl01593 1052585005832 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585005833 NAD(P) binding site [chemical binding]; other site 1052585005834 active site 1052585005835 Necrosis inducing protein (NPP1); Region: NPP1; pfam05630 1052585005836 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 1052585005837 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1052585005838 Cupin domain; Region: Cupin_2; cl09118 1052585005839 Cupin domain; Region: Cupin_2; cl09118 1052585005840 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1052585005841 VanW like protein; Region: VanW; pfam04294 1052585005842 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 1052585005843 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1052585005844 Protein of unknown function (DUF817); Region: DUF817; cl01520 1052585005845 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052585005846 Helix-turn-helix domains; Region: HTH; cl00088 1052585005847 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052585005848 dimerization interface [polypeptide binding]; other site 1052585005849 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1052585005850 EamA-like transporter family; Region: EamA; cl01037 1052585005851 EamA-like transporter family; Region: EamA; cl01037 1052585005852 CAAX protease self-immunity; Region: Abi; cl00558 1052585005853 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1052585005854 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 1052585005855 conserved cys residue [active] 1052585005856 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1052585005857 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052585005858 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1052585005859 Chitin binding domain; Region: Chitin_bind_3; cl03871 1052585005860 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1052585005861 DinB superfamily; Region: DinB_2; pfam12867 1052585005862 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1052585005863 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585005864 Coenzyme A binding pocket [chemical binding]; other site 1052585005865 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 1052585005866 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052585005867 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 1052585005868 active site 1052585005869 active site 1052585005870 catalytic residues [active] 1052585005871 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1052585005872 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052585005873 LysE type translocator; Region: LysE; cl00565 1052585005874 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1052585005875 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 1052585005876 predicted active site [active] 1052585005877 catalytic triad [active] 1052585005878 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1052585005879 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1052585005880 phosphate binding site [ion binding]; other site 1052585005881 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1052585005882 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585005883 DNA-binding site [nucleotide binding]; DNA binding site 1052585005884 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052585005885 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585005886 homodimer interface [polypeptide binding]; other site 1052585005887 catalytic residue [active] 1052585005888 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1052585005889 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1052585005890 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1052585005891 putative substrate binding site [chemical binding]; other site 1052585005892 putative ATP binding site [chemical binding]; other site 1052585005893 maltose O-acetyltransferase; Provisional; Region: PRK10092 1052585005894 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1052585005895 active site 1052585005896 substrate binding site [chemical binding]; other site 1052585005897 trimer interface [polypeptide binding]; other site 1052585005898 CoA binding site [chemical binding]; other site 1052585005899 DNA polymerase IV; Reviewed; Region: PRK03103 1052585005900 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1052585005901 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1052585005902 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1052585005903 dimer interface [polypeptide binding]; other site 1052585005904 putative tRNA-binding site [nucleotide binding]; other site 1052585005905 Cupin domain; Region: Cupin_2; cl09118 1052585005906 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052585005907 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052585005908 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052585005909 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585005910 Helix-turn-helix domains; Region: HTH; cl00088 1052585005911 WHG domain; Region: WHG; pfam13305 1052585005912 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052585005913 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1052585005914 Predicted transcriptional regulator [Transcription]; Region: COG2378 1052585005915 Helix-turn-helix domains; Region: HTH; cl00088 1052585005916 WYL domain; Region: WYL; cl14852 1052585005917 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052585005918 dimerization interface [polypeptide binding]; other site 1052585005919 putative DNA binding site [nucleotide binding]; other site 1052585005920 putative Zn2+ binding site [ion binding]; other site 1052585005921 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1052585005922 Protein of unknown function (DUF420); Region: DUF420; cl00989 1052585005923 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052585005924 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1052585005925 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1052585005926 putative di-iron ligands [ion binding]; other site 1052585005927 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052585005928 Histidine kinase; Region: HisKA_3; pfam07730 1052585005929 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1052585005930 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052585005931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585005932 active site 1052585005933 phosphorylation site [posttranslational modification] 1052585005934 intermolecular recognition site; other site 1052585005935 dimerization interface [polypeptide binding]; other site 1052585005936 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052585005937 DNA binding residues [nucleotide binding] 1052585005938 dimerization interface [polypeptide binding]; other site 1052585005939 putative transporter; Provisional; Region: PRK10484 1052585005940 Sodium:solute symporter family; Region: SSF; cl00456 1052585005941 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1052585005942 putative peptidoglycan binding site; other site 1052585005943 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1052585005944 putative peptidoglycan binding site; other site 1052585005945 cell division protein FtsN; Provisional; Region: PRK12757 1052585005946 3D domain; Region: 3D; cl01439 1052585005947 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1052585005948 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052585005949 ATP binding site [chemical binding]; other site 1052585005950 putative Mg++ binding site [ion binding]; other site 1052585005951 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052585005952 nucleotide binding region [chemical binding]; other site 1052585005953 ATP-binding site [chemical binding]; other site 1052585005954 RQC domain; Region: RQC; cl09632 1052585005955 HRDC domain; Region: HRDC; cl02578 1052585005956 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1052585005957 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1052585005958 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 1052585005959 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 1052585005960 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1052585005961 NAD(P) binding site [chemical binding]; other site 1052585005962 catalytic residues [active] 1052585005963 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 1052585005964 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1052585005965 Active site cavity [active] 1052585005966 Squalene cyclase [Lipid metabolism]; Region: SqhC; COG1657 1052585005967 catalytic acid [active] 1052585005968 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1052585005969 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1052585005970 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1052585005971 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 1052585005972 bile acid transporter; Region: bass; TIGR00841 1052585005973 Membrane transport protein; Region: Mem_trans; cl09117 1052585005974 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1052585005975 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1052585005976 E3 interaction surface; other site 1052585005977 lipoyl attachment site [posttranslational modification]; other site 1052585005978 e3 binding domain; Region: E3_binding; pfam02817 1052585005979 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 1052585005980 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1052585005981 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1052585005982 TPP-binding site [chemical binding]; other site 1052585005983 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1052585005984 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 1052585005985 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 1052585005986 metal ion-dependent adhesion site (MIDAS); other site 1052585005987 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585005988 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1052585005989 Walker A motif; other site 1052585005990 ATP binding site [chemical binding]; other site 1052585005991 Walker B motif; other site 1052585005992 arginine finger; other site 1052585005993 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1052585005994 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1052585005995 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 1052585005996 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1052585005997 E-class dimer interface [polypeptide binding]; other site 1052585005998 P-class dimer interface [polypeptide binding]; other site 1052585005999 active site 1052585006000 Cu2+ binding site [ion binding]; other site 1052585006001 Zn2+ binding site [ion binding]; other site 1052585006002 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1052585006003 putative peptidoglycan binding site; other site 1052585006004 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1052585006005 putative peptidoglycan binding site; other site 1052585006006 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1052585006007 putative peptidoglycan binding site; other site 1052585006008 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1052585006009 putative peptidoglycan binding site; other site 1052585006010 NlpC/P60 family; Region: NLPC_P60; cl11438 1052585006011 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1052585006012 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1052585006013 active site 1052585006014 TDP-binding site; other site 1052585006015 acceptor substrate-binding pocket; other site 1052585006016 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 1052585006017 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1052585006018 multidrug efflux protein; Reviewed; Region: PRK01766 1052585006019 MatE; Region: MatE; cl10513 1052585006020 MatE; Region: MatE; cl10513 1052585006021 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1052585006022 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1052585006023 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 1052585006024 rarD protein; Region: rarD; TIGR00688 1052585006025 EamA-like transporter family; Region: EamA; cl01037 1052585006026 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 1052585006027 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 1052585006028 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052585006029 dimerization interface [polypeptide binding]; other site 1052585006030 putative DNA binding site [nucleotide binding]; other site 1052585006031 putative Zn2+ binding site [ion binding]; other site 1052585006032 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1052585006033 dimer interface [polypeptide binding]; other site 1052585006034 FMN binding site [chemical binding]; other site 1052585006035 Predicted esterase [General function prediction only]; Region: COG0400 1052585006036 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1052585006037 Zn binding site [ion binding]; other site 1052585006038 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1052585006039 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052585006040 Zn binding site [ion binding]; other site 1052585006041 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1052585006042 Sodium:solute symporter family; Region: SSF; cl00456 1052585006043 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1052585006044 C-terminal peptidase (prc); Region: prc; TIGR00225 1052585006045 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1052585006046 protein binding site [polypeptide binding]; other site 1052585006047 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1052585006048 Catalytic dyad [active] 1052585006049 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1052585006050 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1052585006051 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585006052 S-adenosylmethionine binding site [chemical binding]; other site 1052585006053 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1052585006054 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1052585006055 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1052585006056 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1052585006057 YodL-like; Region: YodL; pfam14191 1052585006058 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1052585006059 active site 1052585006060 YozD-like protein; Region: YozD; pfam14162 1052585006061 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 1052585006062 YokU-like protein; Region: YokU; cl15819 1052585006063 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 1052585006064 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052585006065 FeS/SAM binding site; other site 1052585006066 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 1052585006067 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 1052585006068 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585006069 Coenzyme A binding pocket [chemical binding]; other site 1052585006070 acetylornithine deacetylase; Validated; Region: PRK06915 1052585006071 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 1052585006072 metal binding site [ion binding]; metal-binding site 1052585006073 dimer interface [polypeptide binding]; other site 1052585006074 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1052585006075 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1052585006076 hypothetical protein; Provisional; Region: PRK06917 1052585006077 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052585006078 inhibitor-cofactor binding pocket; inhibition site 1052585006079 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585006080 catalytic residue [active] 1052585006081 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585006082 Coenzyme A binding pocket [chemical binding]; other site 1052585006083 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052585006084 active site 1052585006085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1052585006086 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1052585006087 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1052585006088 3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase) [Lipid metabolism]; Region: Phy; COG4247 1052585006089 Phytase; Region: Phytase; pfam02333 1052585006090 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1052585006091 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 1052585006092 NAD(P) binding site [chemical binding]; other site 1052585006093 homodimer interface [polypeptide binding]; other site 1052585006094 substrate binding site [chemical binding]; other site 1052585006095 active site 1052585006096 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 1052585006097 SelR domain; Region: SelR; pfam01641 1052585006098 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 1052585006099 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585006100 Helix-turn-helix domains; Region: HTH; cl00088 1052585006101 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1052585006102 MatE; Region: MatE; cl10513 1052585006103 MatE; Region: MatE; cl10513 1052585006104 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 1052585006105 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1052585006106 active site 1052585006107 catalytic triad [active] 1052585006108 oxyanion hole [active] 1052585006109 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1052585006110 Cu(I) binding site [ion binding]; other site 1052585006111 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 1052585006112 threonine dehydratase; Validated; Region: PRK08639 1052585006113 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1052585006114 tetramer interface [polypeptide binding]; other site 1052585006115 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585006116 catalytic residue [active] 1052585006117 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1052585006118 putative Ile/Val binding site [chemical binding]; other site 1052585006119 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1052585006120 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585006121 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 1052585006122 Haemolysin-III related; Region: HlyIII; cl03831 1052585006123 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052585006124 putative acyl-acceptor binding pocket; other site 1052585006125 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1052585006126 folate binding site [chemical binding]; other site 1052585006127 NADP+ binding site [chemical binding]; other site 1052585006128 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1052585006129 dimerization interface [polypeptide binding]; other site 1052585006130 active site 1052585006131 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1052585006132 tetramer interfaces [polypeptide binding]; other site 1052585006133 binuclear metal-binding site [ion binding]; other site 1052585006134 YpjP-like protein; Region: YpjP; pfam14005 1052585006135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585006136 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1052585006137 Dehydratase family; Region: ILVD_EDD; cl00340 1052585006138 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 1052585006139 Virulence factor; Region: Virulence_fact; pfam13769 1052585006140 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 1052585006141 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 1052585006142 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 1052585006143 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1052585006144 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1052585006145 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1052585006146 catalytic residues [active] 1052585006147 dimer interface [polypeptide binding]; other site 1052585006148 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1052585006149 conserved cys residue [active] 1052585006150 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 1052585006151 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1052585006152 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1052585006153 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 1052585006154 DNA-binding site [nucleotide binding]; DNA binding site 1052585006155 RNA-binding motif; other site 1052585006156 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 1052585006157 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 1052585006158 hypothetical protein; Validated; Region: PRK07708 1052585006159 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1052585006160 RNA/DNA hybrid binding site [nucleotide binding]; other site 1052585006161 active site 1052585006162 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 1052585006163 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1052585006164 RNA/DNA hybrid binding site [nucleotide binding]; other site 1052585006165 active site 1052585006166 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 1052585006167 5'-3' exonuclease; Region: 53EXOc; smart00475 1052585006168 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1052585006169 active site 1052585006170 metal binding site 1 [ion binding]; metal-binding site 1052585006171 putative 5' ssDNA interaction site; other site 1052585006172 metal binding site 3; metal-binding site 1052585006173 metal binding site 2 [ion binding]; metal-binding site 1052585006174 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1052585006175 putative DNA binding site [nucleotide binding]; other site 1052585006176 putative metal binding site [ion binding]; other site 1052585006177 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 1052585006178 ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594 1052585006179 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1052585006180 Dynamin family; Region: Dynamin_N; pfam00350 1052585006181 G1 box; other site 1052585006182 GTP/Mg2+ binding site [chemical binding]; other site 1052585006183 G2 box; other site 1052585006184 Switch I region; other site 1052585006185 G3 box; other site 1052585006186 Switch II region; other site 1052585006187 G4 box; other site 1052585006188 G5 box; other site 1052585006189 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585006190 G1 box; other site 1052585006191 GTP/Mg2+ binding site [chemical binding]; other site 1052585006192 Dynamin family; Region: Dynamin_N; pfam00350 1052585006193 G2 box; other site 1052585006194 Switch I region; other site 1052585006195 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1052585006196 G3 box; other site 1052585006197 Switch II region; other site 1052585006198 GTP/Mg2+ binding site [chemical binding]; other site 1052585006199 G4 box; other site 1052585006200 G5 box; other site 1052585006201 Phospholipid methyltransferase; Region: PEMT; cl00763 1052585006202 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1052585006203 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1052585006204 malonyl-CoA binding site [chemical binding]; other site 1052585006205 dimer interface [polypeptide binding]; other site 1052585006206 active site 1052585006207 product binding site; other site 1052585006208 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1052585006209 xanthine permease; Region: pbuX; TIGR03173 1052585006210 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 1052585006211 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052585006212 active site 1052585006213 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1052585006214 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1052585006215 active site 1052585006216 Zn binding site [ion binding]; other site 1052585006217 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 1052585006218 KDPG and KHG aldolase; Region: Aldolase; pfam01081 1052585006219 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1052585006220 active site 1052585006221 intersubunit interface [polypeptide binding]; other site 1052585006222 catalytic residue [active] 1052585006223 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1052585006224 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1052585006225 substrate binding site [chemical binding]; other site 1052585006226 ATP binding site [chemical binding]; other site 1052585006227 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052585006228 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052585006229 DNA binding site [nucleotide binding] 1052585006230 domain linker motif; other site 1052585006231 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1052585006232 putative dimerization interface [polypeptide binding]; other site 1052585006233 putative ligand binding site [chemical binding]; other site 1052585006234 KduI/IolB family; Region: KduI; cl01508 1052585006235 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 1052585006236 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1052585006237 NADP binding site [chemical binding]; other site 1052585006238 homodimer interface [polypeptide binding]; other site 1052585006239 active site 1052585006240 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1052585006241 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585006242 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585006243 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1052585006244 THUMP domain; Region: THUMP; cl12076 1052585006245 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585006246 cell division protein GpsB; Provisional; Region: PRK14127 1052585006247 DivIVA domain; Region: DivI1A_domain; TIGR03544 1052585006248 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 1052585006249 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 1052585006250 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1052585006251 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1052585006252 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052585006253 ATP binding site [chemical binding]; other site 1052585006254 putative Mg++ binding site [ion binding]; other site 1052585006255 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052585006256 nucleotide binding region [chemical binding]; other site 1052585006257 ATP-binding site [chemical binding]; other site 1052585006258 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1052585006259 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 1052585006260 HPr interaction site; other site 1052585006261 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1052585006262 active site 1052585006263 phosphorylation site [posttranslational modification] 1052585006264 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 1052585006265 YppG-like protein; Region: YppG; pfam14179 1052585006266 YppF-like protein; Region: YppF; pfam14178 1052585006267 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1052585006268 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 1052585006269 Recombination protein U; Region: RecU; cl01314 1052585006270 Transglycosylase; Region: Transgly; cl07896 1052585006271 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1052585006272 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052585006273 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 1052585006274 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1052585006275 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1052585006276 minor groove reading motif; other site 1052585006277 helix-hairpin-helix signature motif; other site 1052585006278 substrate binding pocket [chemical binding]; other site 1052585006279 active site 1052585006280 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1052585006281 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1052585006282 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 1052585006283 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1052585006284 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1052585006285 putative dimer interface [polypeptide binding]; other site 1052585006286 putative anticodon binding site; other site 1052585006287 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1052585006288 homodimer interface [polypeptide binding]; other site 1052585006289 motif 1; other site 1052585006290 motif 2; other site 1052585006291 active site 1052585006292 motif 3; other site 1052585006293 aspartate aminotransferase; Provisional; Region: PRK05764 1052585006294 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052585006295 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585006296 homodimer interface [polypeptide binding]; other site 1052585006297 catalytic residue [active] 1052585006298 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1052585006299 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 1052585006300 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 1052585006301 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1052585006302 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1052585006303 active site 1052585006304 substrate binding site [chemical binding]; other site 1052585006305 catalytic site [active] 1052585006306 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585006307 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1052585006308 tetramerization interface [polypeptide binding]; other site 1052585006309 active site 1052585006310 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1052585006311 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1052585006312 active site 1052585006313 ATP-binding site [chemical binding]; other site 1052585006314 pantoate-binding site; other site 1052585006315 HXXH motif; other site 1052585006316 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1052585006317 oligomerization interface [polypeptide binding]; other site 1052585006318 active site 1052585006319 metal binding site [ion binding]; metal-binding site 1052585006320 Helix-turn-helix domains; Region: HTH; cl00088 1052585006321 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 1052585006322 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1052585006323 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1052585006324 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1052585006325 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1052585006326 active site 1052585006327 NTP binding site [chemical binding]; other site 1052585006328 metal binding triad [ion binding]; metal-binding site 1052585006329 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1052585006330 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1052585006331 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1052585006332 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1052585006333 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1052585006334 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1052585006335 active site 1052585006336 dimer interfaces [polypeptide binding]; other site 1052585006337 catalytic residues [active] 1052585006338 dihydrodipicolinate reductase; Region: dapB; TIGR00036 1052585006339 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585006340 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1052585006341 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 1052585006342 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1052585006343 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052585006344 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052585006345 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 1052585006346 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 1052585006347 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 1052585006348 Cytochrome c; Region: Cytochrom_C; cl11414 1052585006349 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1052585006350 interchain domain interface [polypeptide binding]; other site 1052585006351 intrachain domain interface; other site 1052585006352 heme bH binding site [chemical binding]; other site 1052585006353 Qi binding site; other site 1052585006354 heme bL binding site [chemical binding]; other site 1052585006355 Qo binding site; other site 1052585006356 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1052585006357 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 1052585006358 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1052585006359 iron-sulfur cluster [ion binding]; other site 1052585006360 [2Fe-2S] cluster binding site [ion binding]; other site 1052585006361 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 1052585006362 hypothetical protein; Provisional; Region: PRK03636 1052585006363 UPF0302 domain; Region: UPF0302; pfam08864 1052585006364 IDEAL domain; Region: IDEAL; cl07452 1052585006365 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585006366 TPR motif; other site 1052585006367 binding surface 1052585006368 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585006369 binding surface 1052585006370 TPR motif; other site 1052585006371 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1052585006372 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585006373 TPR motif; other site 1052585006374 binding surface 1052585006375 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1052585006376 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585006377 binding surface 1052585006378 TPR motif; other site 1052585006379 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1052585006380 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1052585006381 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 1052585006382 hinge; other site 1052585006383 active site 1052585006384 prephenate dehydrogenase; Validated; Region: PRK06545 1052585006385 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585006386 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1052585006387 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1052585006388 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052585006389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585006390 homodimer interface [polypeptide binding]; other site 1052585006391 catalytic residue [active] 1052585006392 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 1052585006393 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1052585006394 substrate binding site [chemical binding]; other site 1052585006395 active site 1052585006396 catalytic residues [active] 1052585006397 heterodimer interface [polypeptide binding]; other site 1052585006398 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1052585006399 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1052585006400 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585006401 catalytic residue [active] 1052585006402 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 1052585006403 active site 1052585006404 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1052585006405 active site 1052585006406 ribulose/triose binding site [chemical binding]; other site 1052585006407 phosphate binding site [ion binding]; other site 1052585006408 substrate (anthranilate) binding pocket [chemical binding]; other site 1052585006409 product (indole) binding pocket [chemical binding]; other site 1052585006410 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1052585006411 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1052585006412 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1052585006413 anthranilate synthase component I; Provisional; Region: PRK13569 1052585006414 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1052585006415 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1052585006416 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 1052585006417 homotrimer interaction site [polypeptide binding]; other site 1052585006418 active site 1052585006419 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1052585006420 active site 1052585006421 dimer interface [polypeptide binding]; other site 1052585006422 metal binding site [ion binding]; metal-binding site 1052585006423 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1052585006424 Tetramer interface [polypeptide binding]; other site 1052585006425 active site 1052585006426 FMN-binding site [chemical binding]; other site 1052585006427 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1052585006428 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1052585006429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585006430 S-adenosylmethionine binding site [chemical binding]; other site 1052585006431 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1052585006432 active site 1052585006433 multimer interface [polypeptide binding]; other site 1052585006434 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1052585006435 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1052585006436 substrate binding pocket [chemical binding]; other site 1052585006437 chain length determination region; other site 1052585006438 substrate-Mg2+ binding site; other site 1052585006439 catalytic residues [active] 1052585006440 aspartate-rich region 1; other site 1052585006441 active site lid residues [active] 1052585006442 aspartate-rich region 2; other site 1052585006443 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1052585006444 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585006445 S-adenosylmethionine binding site [chemical binding]; other site 1052585006446 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1052585006447 Tryptophan RNA-binding attenuator protein; Region: TrpBP; cl03437 1052585006448 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1052585006449 homodecamer interface [polypeptide binding]; other site 1052585006450 GTP cyclohydrolase I; Provisional; Region: PLN03044 1052585006451 active site 1052585006452 putative catalytic site residues [active] 1052585006453 zinc binding site [ion binding]; other site 1052585006454 GTP-CH-I/GFRP interaction surface; other site 1052585006455 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1052585006456 IHF dimer interface [polypeptide binding]; other site 1052585006457 IHF - DNA interface [nucleotide binding]; other site 1052585006458 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 1052585006459 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1052585006460 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585006461 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1052585006462 GTP-binding protein Der; Reviewed; Region: PRK00093 1052585006463 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1052585006464 G1 box; other site 1052585006465 GTP/Mg2+ binding site [chemical binding]; other site 1052585006466 Switch I region; other site 1052585006467 G2 box; other site 1052585006468 Switch II region; other site 1052585006469 G3 box; other site 1052585006470 G4 box; other site 1052585006471 G5 box; other site 1052585006472 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1052585006473 G1 box; other site 1052585006474 GTP/Mg2+ binding site [chemical binding]; other site 1052585006475 Switch I region; other site 1052585006476 G2 box; other site 1052585006477 G3 box; other site 1052585006478 Switch II region; other site 1052585006479 G4 box; other site 1052585006480 G5 box; other site 1052585006481 YIEGIA protein; Region: YIEGIA; pfam14045 1052585006482 YpzI-like protein; Region: YpzI; pfam14140 1052585006483 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1052585006484 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1052585006485 homotetramer interface [polypeptide binding]; other site 1052585006486 FMN binding site [chemical binding]; other site 1052585006487 homodimer contacts [polypeptide binding]; other site 1052585006488 putative active site [active] 1052585006489 putative substrate binding site [chemical binding]; other site 1052585006490 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1052585006491 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1052585006492 RNA binding site [nucleotide binding]; other site 1052585006493 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1052585006494 RNA binding site [nucleotide binding]; other site 1052585006495 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1052585006496 RNA binding site [nucleotide binding]; other site 1052585006497 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 1052585006498 RNA binding site [nucleotide binding]; other site 1052585006499 cytidylate kinase; Provisional; Region: cmk; PRK00023 1052585006500 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1052585006501 CMP-binding site; other site 1052585006502 The sites determining sugar specificity; other site 1052585006503 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1052585006504 Flagellar protein YcgR; Region: YcgR_2; pfam12945 1052585006505 PilZ domain; Region: PilZ; cl01260 1052585006506 germination protein YpeB; Region: spore_YpeB; TIGR02889 1052585006507 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1052585006508 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1052585006509 Protease prsW family; Region: PrsW-protease; cl15823 1052585006510 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1052585006511 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585006512 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052585006513 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1052585006514 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1052585006515 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1052585006516 NAD(P) binding site [chemical binding]; other site 1052585006517 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 1052585006518 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1052585006519 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1052585006520 putative active site [active] 1052585006521 putative metal binding site [ion binding]; other site 1052585006522 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 1052585006523 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 1052585006524 CAAX protease self-immunity; Region: Abi; cl00558 1052585006525 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1052585006526 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052585006527 ATP binding site [chemical binding]; other site 1052585006528 putative Mg++ binding site [ion binding]; other site 1052585006529 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052585006530 nucleotide binding region [chemical binding]; other site 1052585006531 ATP-binding site [chemical binding]; other site 1052585006532 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1052585006533 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1052585006534 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 1052585006535 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1052585006536 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1052585006537 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585006538 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1052585006539 putative L-serine binding site [chemical binding]; other site 1052585006540 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1052585006541 3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093 1052585006542 active site 1052585006543 catalytic residue [active] 1052585006544 dimer interface [polypeptide binding]; other site 1052585006545 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 1052585006546 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052585006547 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052585006548 DNA binding residues [nucleotide binding] 1052585006549 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1052585006550 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052585006551 dimerization interface [polypeptide binding]; other site 1052585006552 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1052585006553 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052585006554 dimer interface [polypeptide binding]; other site 1052585006555 phosphorylation site [posttranslational modification] 1052585006556 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585006557 ATP binding site [chemical binding]; other site 1052585006558 Mg2+ binding site [ion binding]; other site 1052585006559 G-X-G motif; other site 1052585006560 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052585006561 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585006562 active site 1052585006563 phosphorylation site [posttranslational modification] 1052585006564 intermolecular recognition site; other site 1052585006565 dimerization interface [polypeptide binding]; other site 1052585006566 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052585006567 DNA binding site [nucleotide binding] 1052585006568 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1052585006569 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1052585006570 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1052585006571 ResB-like family; Region: ResB; pfam05140 1052585006572 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1052585006573 catalytic residues [active] 1052585006574 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1052585006575 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1052585006576 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 1052585006577 active site 1052585006578 Nucleoside recognition; Region: Gate; cl00486 1052585006579 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1052585006580 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052585006581 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 1052585006582 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 1052585006583 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 1052585006584 ScpA/B protein; Region: ScpA_ScpB; cl00598 1052585006585 Domain of unknown function (DUF309); Region: DUF309; cl00667 1052585006586 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585006587 Coenzyme A binding pocket [chemical binding]; other site 1052585006588 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1052585006589 homopentamer interface [polypeptide binding]; other site 1052585006590 active site 1052585006591 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1052585006592 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 1052585006593 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1052585006594 dimerization interface [polypeptide binding]; other site 1052585006595 active site 1052585006596 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1052585006597 Lumazine binding domain; Region: Lum_binding; pfam00677 1052585006598 Lumazine binding domain; Region: Lum_binding; pfam00677 1052585006599 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1052585006600 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1052585006601 catalytic motif [active] 1052585006602 Zn binding site [ion binding]; other site 1052585006603 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1052585006604 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1052585006605 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1052585006606 Catalytic site [active] 1052585006607 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381 1052585006608 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1052585006609 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1052585006610 active site 1052585006611 Predicted secreted protein [Function unknown]; Region: COG4086 1052585006612 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1052585006613 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1052585006614 active site 1052585006615 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1052585006616 substrate binding site [chemical binding]; other site 1052585006617 catalytic residues [active] 1052585006618 dimer interface [polypeptide binding]; other site 1052585006619 stage V sporulation protein AD; Validated; Region: PRK08304 1052585006620 stage V sporulation protein AD; Provisional; Region: PRK12404 1052585006621 SpoVA protein; Region: SpoVA; cl04298 1052585006622 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 1052585006623 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 1052585006624 sporulation sigma factor SigF; Validated; Region: PRK05572 1052585006625 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052585006626 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1052585006627 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052585006628 DNA binding residues [nucleotide binding] 1052585006629 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1052585006630 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585006631 ATP binding site [chemical binding]; other site 1052585006632 Mg2+ binding site [ion binding]; other site 1052585006633 G-X-G motif; other site 1052585006634 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 1052585006635 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1052585006636 Sulfatase; Region: Sulfatase; cl10460 1052585006637 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1052585006638 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1052585006639 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1052585006640 Int/Topo IB signature motif; other site 1052585006641 active site 1052585006642 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 1052585006643 ferric uptake regulator; Provisional; Region: fur; PRK09462 1052585006644 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1052585006645 metal binding site 2 [ion binding]; metal-binding site 1052585006646 putative DNA binding helix; other site 1052585006647 metal binding site 1 [ion binding]; metal-binding site 1052585006648 dimer interface [polypeptide binding]; other site 1052585006649 structural Zn2+ binding site [ion binding]; other site 1052585006650 Integral membrane protein DUF95; Region: DUF95; cl00572 1052585006651 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1052585006652 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1052585006653 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585006654 NAD(P) binding pocket [chemical binding]; other site 1052585006655 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1052585006656 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1052585006657 Aspartase; Region: Aspartase; cd01357 1052585006658 active sites [active] 1052585006659 tetramer interface [polypeptide binding]; other site 1052585006660 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1052585006661 active site 1052585006662 homodimer interface [polypeptide binding]; other site 1052585006663 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1052585006664 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052585006665 non-specific DNA binding site [nucleotide binding]; other site 1052585006666 salt bridge; other site 1052585006667 sequence-specific DNA binding site [nucleotide binding]; other site 1052585006668 TIGR00375 family protein; Region: TIGR00375 1052585006669 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1052585006670 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1052585006671 dimer interface [polypeptide binding]; other site 1052585006672 ADP-ribose binding site [chemical binding]; other site 1052585006673 active site 1052585006674 nudix motif; other site 1052585006675 metal binding site [ion binding]; metal-binding site 1052585006676 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 1052585006677 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1052585006678 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052585006679 active site 1052585006680 catalytic tetrad [active] 1052585006681 Protein of unknown function (DUF3886); Region: DUF3886; pfam13025 1052585006682 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052585006683 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1052585006684 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750 1052585006685 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1052585006686 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1052585006687 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1052585006688 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 1052585006689 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 1052585006690 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1052585006691 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585006692 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052585006693 Coenzyme A binding pocket [chemical binding]; other site 1052585006694 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 1052585006695 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1052585006696 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1052585006697 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585006698 Coenzyme A binding pocket [chemical binding]; other site 1052585006699 YolD-like protein; Region: YolD; pfam08863 1052585006700 DNA polymerase IV; Reviewed; Region: PRK03103 1052585006701 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1052585006702 active site 1052585006703 DNA binding site [nucleotide binding] 1052585006704 YqzH-like protein; Region: YqzH; pfam14164 1052585006705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585006706 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585006707 putative substrate translocation pore; other site 1052585006708 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1052585006709 putative dimer interface [polypeptide binding]; other site 1052585006710 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052585006711 ligand binding site [chemical binding]; other site 1052585006712 Zn binding site [ion binding]; other site 1052585006713 pantothenate kinase; Provisional; Region: PRK05439 1052585006714 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 1052585006715 ATP-binding site [chemical binding]; other site 1052585006716 CoA-binding site [chemical binding]; other site 1052585006717 Mg2+-binding site [ion binding]; other site 1052585006718 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1052585006719 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052585006720 catalytic residue [active] 1052585006721 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1052585006722 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332 1052585006723 NADP binding site [chemical binding]; other site 1052585006724 homodimer interface [polypeptide binding]; other site 1052585006725 substrate binding site [chemical binding]; other site 1052585006726 active site 1052585006727 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1052585006728 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052585006729 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585006730 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1052585006731 Arginine degradation protein (predicted deacylase) [Amino acid transport and metabolism]; Region: RocB; COG4187 1052585006732 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 1052585006733 putative metal binding site [ion binding]; other site 1052585006734 putative dimer interface [polypeptide binding]; other site 1052585006735 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1052585006736 active site 1052585006737 FMN binding site [chemical binding]; other site 1052585006738 substrate binding site [chemical binding]; other site 1052585006739 homotetramer interface [polypeptide binding]; other site 1052585006740 catalytic residue [active] 1052585006741 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052585006742 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 1052585006743 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052585006744 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1052585006745 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1052585006746 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1052585006747 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585006748 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1052585006749 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1052585006750 DNA polymerase IV; Validated; Region: PRK01810 1052585006751 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1052585006752 active site 1052585006753 DNA binding site [nucleotide binding] 1052585006754 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1052585006755 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1052585006756 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 1052585006757 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1052585006758 peptidase T-like protein; Region: PepT-like; TIGR01883 1052585006759 metal binding site [ion binding]; metal-binding site 1052585006760 putative dimer interface [polypeptide binding]; other site 1052585006761 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 1052585006762 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1052585006763 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1052585006764 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052585006765 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1052585006766 dimer interface [polypeptide binding]; other site 1052585006767 substrate binding site [chemical binding]; other site 1052585006768 metal binding site [ion binding]; metal-binding site 1052585006769 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 1052585006770 Predicted membrane protein [Function unknown]; Region: COG4129 1052585006771 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 1052585006772 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1052585006773 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1052585006774 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1052585006775 Walker A/P-loop; other site 1052585006776 ATP binding site [chemical binding]; other site 1052585006777 Q-loop/lid; other site 1052585006778 ABC transporter signature motif; other site 1052585006779 Walker B; other site 1052585006780 D-loop; other site 1052585006781 H-loop/switch region; other site 1052585006782 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1052585006783 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585006784 dimer interface [polypeptide binding]; other site 1052585006785 conserved gate region; other site 1052585006786 putative PBP binding loops; other site 1052585006787 ABC-ATPase subunit interface; other site 1052585006788 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1052585006789 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1052585006790 substrate binding pocket [chemical binding]; other site 1052585006791 membrane-bound complex binding site; other site 1052585006792 hinge residues; other site 1052585006793 Disulphide isomerase; Region: Disulph_isomer; pfam06491 1052585006794 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1052585006795 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1052585006796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585006797 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585006798 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585006799 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1052585006800 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1052585006801 DNA binding residues [nucleotide binding] 1052585006802 drug binding residues [chemical binding]; other site 1052585006803 dimer interface [polypeptide binding]; other site 1052585006804 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1052585006805 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1052585006806 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1052585006807 E3 interaction surface; other site 1052585006808 lipoyl attachment site [posttranslational modification]; other site 1052585006809 e3 binding domain; Region: E3_binding; pfam02817 1052585006810 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 1052585006811 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1052585006812 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1052585006813 alpha subunit interface [polypeptide binding]; other site 1052585006814 TPP binding site [chemical binding]; other site 1052585006815 heterodimer interface [polypeptide binding]; other site 1052585006816 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1052585006817 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1052585006818 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1052585006819 tetramer interface [polypeptide binding]; other site 1052585006820 TPP-binding site [chemical binding]; other site 1052585006821 heterodimer interface [polypeptide binding]; other site 1052585006822 phosphorylation loop region [posttranslational modification] 1052585006823 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1052585006824 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585006825 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052585006826 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1052585006827 Acetokinase family; Region: Acetate_kinase; cl01029 1052585006828 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1052585006829 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1052585006830 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1052585006831 NAD binding site [chemical binding]; other site 1052585006832 Phe binding site; other site 1052585006833 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1052585006834 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 1052585006835 acetaldehyde dehydrogenase (acetylating); Region: ac_ald_DH_ac; TIGR03215 1052585006836 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1052585006837 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052585006838 putative active site [active] 1052585006839 heme pocket [chemical binding]; other site 1052585006840 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1052585006841 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585006842 Walker A motif; other site 1052585006843 ATP binding site [chemical binding]; other site 1052585006844 Walker B motif; other site 1052585006845 arginine finger; other site 1052585006846 Helix-turn-helix domains; Region: HTH; cl00088 1052585006847 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 1052585006848 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 1052585006849 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1052585006850 tetramer interface [polypeptide binding]; other site 1052585006851 active site 1052585006852 Mg2+/Mn2+ binding site [ion binding]; other site 1052585006853 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1052585006854 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 1052585006855 dimer interface [polypeptide binding]; other site 1052585006856 Citrate synthase; Region: Citrate_synt; pfam00285 1052585006857 active site 1052585006858 coenzyme A binding site [chemical binding]; other site 1052585006859 citrylCoA binding site [chemical binding]; other site 1052585006860 oxalacetate/citrate binding site [chemical binding]; other site 1052585006861 catalytic triad [active] 1052585006862 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1052585006863 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1052585006864 FAD binding site [chemical binding]; other site 1052585006865 homotetramer interface [polypeptide binding]; other site 1052585006866 substrate binding pocket [chemical binding]; other site 1052585006867 catalytic base [active] 1052585006868 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1052585006869 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585006870 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1052585006871 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 1052585006872 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1052585006873 dimer interface [polypeptide binding]; other site 1052585006874 active site 1052585006875 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1052585006876 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1052585006877 active site 1052585006878 catalytic site [active] 1052585006879 metal binding site [ion binding]; metal-binding site 1052585006880 dimer interface [polypeptide binding]; other site 1052585006881 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 1052585006882 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1052585006883 active site 1052585006884 metal binding site [ion binding]; metal-binding site 1052585006885 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1052585006886 putative active site [active] 1052585006887 putative FMN binding site [chemical binding]; other site 1052585006888 putative substrate binding site [chemical binding]; other site 1052585006889 putative catalytic residue [active] 1052585006890 Protein of unknown function DUF45; Region: DUF45; cl00636 1052585006891 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 1052585006892 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1052585006893 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052585006894 ATP binding site [chemical binding]; other site 1052585006895 putative Mg++ binding site [ion binding]; other site 1052585006896 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1052585006897 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1052585006898 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1052585006899 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1052585006900 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1052585006901 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585006902 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1052585006903 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1052585006904 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1052585006905 DNA binding site [nucleotide binding] 1052585006906 Int/Topo IB signature motif; other site 1052585006907 active site 1052585006908 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 1052585006909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585006910 active site 1052585006911 phosphorylation site [posttranslational modification] 1052585006912 intermolecular recognition site; other site 1052585006913 dimerization interface [polypeptide binding]; other site 1052585006914 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 1052585006915 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 1052585006916 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1052585006917 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 1052585006918 DNA repair protein RecN; Region: recN; TIGR00634 1052585006919 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 1052585006920 Walker A/P-loop; other site 1052585006921 ATP binding site [chemical binding]; other site 1052585006922 Q-loop/lid; other site 1052585006923 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 1052585006924 ABC transporter signature motif; other site 1052585006925 Walker B; other site 1052585006926 D-loop; other site 1052585006927 H-loop/switch region; other site 1052585006928 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1052585006929 arginine repressor; Provisional; Region: PRK04280 1052585006930 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1052585006931 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1052585006932 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052585006933 RNA binding surface [nucleotide binding]; other site 1052585006934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 1052585006935 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 1052585006936 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1052585006937 TPP-binding site; other site 1052585006938 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1052585006939 PYR/PP interface [polypeptide binding]; other site 1052585006940 dimer interface [polypeptide binding]; other site 1052585006941 TPP binding site [chemical binding]; other site 1052585006942 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1052585006943 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1052585006944 substrate binding pocket [chemical binding]; other site 1052585006945 chain length determination region; other site 1052585006946 substrate-Mg2+ binding site; other site 1052585006947 catalytic residues [active] 1052585006948 aspartate-rich region 1; other site 1052585006949 active site lid residues [active] 1052585006950 aspartate-rich region 2; other site 1052585006951 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 1052585006952 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 1052585006953 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1052585006954 generic binding surface II; other site 1052585006955 generic binding surface I; other site 1052585006956 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1052585006957 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1052585006958 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1052585006959 homodimer interface [polypeptide binding]; other site 1052585006960 NADP binding site [chemical binding]; other site 1052585006961 substrate binding site [chemical binding]; other site 1052585006962 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1052585006963 putative RNA binding site [nucleotide binding]; other site 1052585006964 Asp23 family; Region: Asp23; cl00574 1052585006965 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1052585006966 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052585006967 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 1052585006968 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1052585006969 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1052585006970 carboxyltransferase (CT) interaction site; other site 1052585006971 biotinylation site [posttranslational modification]; other site 1052585006972 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 1052585006973 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 1052585006974 stage III sporulation protein AF; Region: spore_III_AF; TIGR02896 1052585006975 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 1052585006976 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 1052585006977 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 1052585006978 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 1052585006979 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 1052585006980 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 1052585006981 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585006982 Walker A motif; other site 1052585006983 ATP binding site [chemical binding]; other site 1052585006984 Walker B motif; other site 1052585006985 arginine finger; other site 1052585006986 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 1052585006987 elongation factor P; Validated; Region: PRK00529 1052585006988 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1052585006989 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1052585006990 RNA binding site [nucleotide binding]; other site 1052585006991 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1052585006992 RNA binding site [nucleotide binding]; other site 1052585006993 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1052585006994 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1052585006995 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1052585006996 active site 1052585006997 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1052585006998 trimer interface [polypeptide binding]; other site 1052585006999 active site 1052585007000 dimer interface [polypeptide binding]; other site 1052585007001 Conserved membrane protein YqhR; Region: YqhR; pfam11085 1052585007002 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 1052585007003 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1052585007004 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1052585007005 active site 1052585007006 nucleophile elbow; other site 1052585007007 manganese transport transcriptional regulator; Provisional; Region: PRK03902 1052585007008 Helix-turn-helix domains; Region: HTH; cl00088 1052585007009 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1052585007010 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1052585007011 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1052585007012 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1052585007013 active site residue [active] 1052585007014 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 1052585007015 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1052585007016 tetramer interface [polypeptide binding]; other site 1052585007017 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585007018 catalytic residue [active] 1052585007019 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1052585007020 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1052585007021 tetramer interface [polypeptide binding]; other site 1052585007022 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585007023 catalytic residue [active] 1052585007024 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1052585007025 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1052585007026 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1052585007027 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1052585007028 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052585007029 ATP binding site [chemical binding]; other site 1052585007030 putative Mg++ binding site [ion binding]; other site 1052585007031 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052585007032 nucleotide binding region [chemical binding]; other site 1052585007033 ATP-binding site [chemical binding]; other site 1052585007034 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 1052585007035 Anti-repressor SinI; Region: SinI; pfam08671 1052585007036 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052585007037 non-specific DNA binding site [nucleotide binding]; other site 1052585007038 salt bridge; other site 1052585007039 sequence-specific DNA binding site [nucleotide binding]; other site 1052585007040 Anti-repressor SinI; Region: SinI; pfam08671 1052585007041 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 1052585007042 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 1052585007043 Catalytic site [active] 1052585007044 YqxM protein; Region: YqxM_for_SipW; TIGR04087 1052585007045 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1052585007046 YqzE-like protein; Region: YqzE; pfam14038 1052585007047 ComG operon protein 7; Region: ComGG; pfam14173 1052585007048 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1052585007049 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1052585007050 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 1052585007051 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 1052585007052 Type II/IV secretion system protein; Region: T2SE; pfam00437 1052585007053 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1052585007054 Walker A motif; other site 1052585007055 ATP binding site [chemical binding]; other site 1052585007056 Walker B motif; other site 1052585007057 FOG: CBS domain [General function prediction only]; Region: COG0517 1052585007058 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1052585007059 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1052585007060 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 1052585007061 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1052585007062 Domain of unknown function DUF21; Region: DUF21; pfam01595 1052585007063 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1052585007064 Transporter associated domain; Region: CorC_HlyC; cl08393 1052585007065 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 1052585007066 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1052585007067 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1052585007068 ArsC family; Region: ArsC; pfam03960 1052585007069 putative catalytic residues [active] 1052585007070 thiol/disulfide switch; other site 1052585007071 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 1052585007072 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052585007073 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 1052585007074 Domain of unknown function DUF77; Region: DUF77; cl00307 1052585007075 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1052585007076 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 1052585007077 putative active site [active] 1052585007078 Zn binding site [ion binding]; other site 1052585007079 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1052585007080 Sulfatase; Region: Sulfatase; cl10460 1052585007081 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1052585007082 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 1052585007083 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 1052585007084 Rhomboid family; Region: Rhomboid; cl11446 1052585007085 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585007086 binding surface 1052585007087 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1052585007088 TPR motif; other site 1052585007089 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1052585007090 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 1052585007091 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052585007092 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1052585007093 proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675 1052585007094 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274 1052585007095 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 1052585007096 Walker A/P-loop; other site 1052585007097 ATP binding site [chemical binding]; other site 1052585007098 Q-loop/lid; other site 1052585007099 ABC transporter signature motif; other site 1052585007100 Walker B; other site 1052585007101 D-loop; other site 1052585007102 H-loop/switch region; other site 1052585007103 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248 1052585007104 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 1052585007105 Walker A/P-loop; other site 1052585007106 ATP binding site [chemical binding]; other site 1052585007107 Q-loop/lid; other site 1052585007108 ABC transporter signature motif; other site 1052585007109 Walker B; other site 1052585007110 D-loop; other site 1052585007111 H-loop/switch region; other site 1052585007112 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1052585007113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585007114 dimer interface [polypeptide binding]; other site 1052585007115 conserved gate region; other site 1052585007116 ABC-ATPase subunit interface; other site 1052585007117 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1052585007118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585007119 dimer interface [polypeptide binding]; other site 1052585007120 conserved gate region; other site 1052585007121 putative PBP binding loops; other site 1052585007122 ABC-ATPase subunit interface; other site 1052585007123 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1052585007124 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1052585007125 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1052585007126 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1052585007127 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052585007128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585007129 putative substrate translocation pore; other site 1052585007130 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1052585007131 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1052585007132 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1052585007133 Protein of unknown function (DUF456); Region: DUF456; cl01069 1052585007134 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 1052585007135 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1052585007136 putative peptidoglycan binding site; other site 1052585007137 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1052585007138 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1052585007139 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1052585007140 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1052585007141 ferric uptake regulator; Provisional; Region: fur; PRK09462 1052585007142 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1052585007143 metal binding site 2 [ion binding]; metal-binding site 1052585007144 putative DNA binding helix; other site 1052585007145 metal binding site 1 [ion binding]; metal-binding site 1052585007146 dimer interface [polypeptide binding]; other site 1052585007147 structural Zn2+ binding site [ion binding]; other site 1052585007148 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1052585007149 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052585007150 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052585007151 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 1052585007152 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 1052585007153 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1052585007154 endonuclease IV; Provisional; Region: PRK01060 1052585007155 AP (apurinic/apyrimidinic) site pocket; other site 1052585007156 DNA interaction; other site 1052585007157 Metal-binding active site; metal-binding site 1052585007158 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1052585007159 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1052585007160 ATP binding site [chemical binding]; other site 1052585007161 Mg++ binding site [ion binding]; other site 1052585007162 motif III; other site 1052585007163 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052585007164 nucleotide binding region [chemical binding]; other site 1052585007165 ATP-binding site [chemical binding]; other site 1052585007166 YqfQ-like protein; Region: YqfQ; pfam14181 1052585007167 LytB protein; Region: LYTB; cl00507 1052585007168 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 1052585007169 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1052585007170 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1052585007171 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1052585007172 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585007173 Cytochrome c; Region: Cytochrom_C; cl11414 1052585007174 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1052585007175 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1052585007176 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1052585007177 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052585007178 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1052585007179 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052585007180 DNA binding residues [nucleotide binding] 1052585007181 DNA primase; Validated; Region: dnaG; PRK05667 1052585007182 CHC2 zinc finger; Region: zf-CHC2; cl15369 1052585007183 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1052585007184 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1052585007185 active site 1052585007186 metal binding site [ion binding]; metal-binding site 1052585007187 interdomain interaction site; other site 1052585007188 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1052585007189 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 1052585007190 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 1052585007191 Helix-turn-helix domains; Region: HTH; cl00088 1052585007192 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1052585007193 FOG: CBS domain [General function prediction only]; Region: COG0517 1052585007194 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 1052585007195 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1052585007196 dimer interface [polypeptide binding]; other site 1052585007197 motif 1; other site 1052585007198 active site 1052585007199 motif 2; other site 1052585007200 motif 3; other site 1052585007201 Recombination protein O N terminal; Region: RecO_N; cl15812 1052585007202 DNA repair protein RecO; Region: reco; TIGR00613 1052585007203 Recombination protein O C terminal; Region: RecO_C; pfam02565 1052585007204 YqzL-like protein; Region: YqzL; pfam14006 1052585007205 GTPase Era; Reviewed; Region: era; PRK00089 1052585007206 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1052585007207 G1 box; other site 1052585007208 GTP/Mg2+ binding site [chemical binding]; other site 1052585007209 Switch I region; other site 1052585007210 G2 box; other site 1052585007211 Switch II region; other site 1052585007212 G3 box; other site 1052585007213 G4 box; other site 1052585007214 G5 box; other site 1052585007215 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 1052585007216 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1052585007217 active site 1052585007218 catalytic motif [active] 1052585007219 Zn binding site [ion binding]; other site 1052585007220 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 1052585007221 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 1052585007222 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1052585007223 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 1052585007224 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052585007225 Zn2+ binding site [ion binding]; other site 1052585007226 Mg2+ binding site [ion binding]; other site 1052585007227 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1052585007228 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585007229 YabP family; Region: YabP; cl06766 1052585007230 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 1052585007231 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1052585007232 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 1052585007233 dimer interface [polypeptide binding]; other site 1052585007234 active site residues [active] 1052585007235 GatB domain; Region: GatB_Yqey; cl11497 1052585007236 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 1052585007237 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 1052585007238 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1052585007239 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1052585007240 radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089 1052585007241 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1052585007242 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052585007243 FeS/SAM binding site; other site 1052585007244 TRAM domain; Region: TRAM; cl01282 1052585007245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 1052585007246 RNA methyltransferase, RsmE family; Region: TIGR00046 1052585007247 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 1052585007248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585007249 S-adenosylmethionine binding site [chemical binding]; other site 1052585007250 chaperone protein DnaJ; Provisional; Region: PRK14280 1052585007251 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1052585007252 HSP70 interaction site [polypeptide binding]; other site 1052585007253 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1052585007254 substrate binding site [polypeptide binding]; other site 1052585007255 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1052585007256 Zn binding sites [ion binding]; other site 1052585007257 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1052585007258 dimer interface [polypeptide binding]; other site 1052585007259 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1052585007260 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1052585007261 dimer interface [polypeptide binding]; other site 1052585007262 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1052585007263 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1052585007264 Helix-turn-helix domains; Region: HTH; cl00088 1052585007265 HrcA protein C terminal domain; Region: HrcA; pfam01628 1052585007266 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1052585007267 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052585007268 FeS/SAM binding site; other site 1052585007269 HemN C-terminal domain; Region: HemN_C; pfam06969 1052585007270 GTP-binding protein LepA; Provisional; Region: PRK05433 1052585007271 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1052585007272 G1 box; other site 1052585007273 putative GEF interaction site [polypeptide binding]; other site 1052585007274 GTP/Mg2+ binding site [chemical binding]; other site 1052585007275 Switch I region; other site 1052585007276 G2 box; other site 1052585007277 G3 box; other site 1052585007278 Switch II region; other site 1052585007279 G4 box; other site 1052585007280 G5 box; other site 1052585007281 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1052585007282 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1052585007283 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1052585007284 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 1052585007285 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 1052585007286 stage II sporulation protein P; Region: spore_II_P; TIGR02867 1052585007287 Germination protease; Region: Peptidase_A25; cl04057 1052585007288 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 1052585007289 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1052585007290 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1052585007291 YqzM-like protein; Region: YqzM; pfam14141 1052585007292 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 1052585007293 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1052585007294 Competence protein; Region: Competence; cl00471 1052585007295 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052585007296 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1052585007297 catalytic motif [active] 1052585007298 Zn binding site [ion binding]; other site 1052585007299 SLBB domain; Region: SLBB; pfam10531 1052585007300 comEA protein; Region: comE; TIGR01259 1052585007301 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1052585007302 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585007303 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1052585007304 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1052585007305 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585007306 S-adenosylmethionine binding site [chemical binding]; other site 1052585007307 Oligomerisation domain; Region: Oligomerisation; cl00519 1052585007308 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 1052585007309 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052585007310 Zn2+ binding site [ion binding]; other site 1052585007311 Mg2+ binding site [ion binding]; other site 1052585007312 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1052585007313 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1052585007314 active site 1052585007315 (T/H)XGH motif; other site 1052585007316 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 1052585007317 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 1052585007318 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1052585007319 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1052585007320 shikimate binding site; other site 1052585007321 NAD(P) binding site [chemical binding]; other site 1052585007322 GTPase YqeH; Provisional; Region: PRK13796 1052585007323 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1052585007324 GTP/Mg2+ binding site [chemical binding]; other site 1052585007325 G4 box; other site 1052585007326 G5 box; other site 1052585007327 G1 box; other site 1052585007328 Switch I region; other site 1052585007329 G2 box; other site 1052585007330 G3 box; other site 1052585007331 Switch II region; other site 1052585007332 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1052585007333 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585007334 active site 1052585007335 motif I; other site 1052585007336 motif II; other site 1052585007337 Sporulation inhibitor A; Region: Sda; pfam08970 1052585007338 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1052585007339 active site 1052585007340 catalytic triad [active] 1052585007341 oxyanion hole [active] 1052585007342 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1052585007343 amidase catalytic site [active] 1052585007344 Zn binding residues [ion binding]; other site 1052585007345 substrate binding site [chemical binding]; other site 1052585007346 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1052585007347 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1052585007348 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 1052585007349 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585007350 arginine decarboxylase; Provisional; Region: PRK15029 1052585007351 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1052585007352 sporulation sigma factor SigK; Reviewed; Region: PRK05803 1052585007353 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052585007354 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052585007355 DNA binding residues [nucleotide binding] 1052585007356 alanyl-tRNA synthetase; Provisional; Region: alaS; PRK13902 1052585007357 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 1052585007358 DHHA1 domain; Region: DHHA1; pfam02272 1052585007359 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1052585007360 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 1052585007361 dimer interface [polypeptide binding]; other site 1052585007362 active site 1052585007363 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1052585007364 substrate binding site [chemical binding]; other site 1052585007365 catalytic residue [active] 1052585007366 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1052585007367 homotrimer interaction site [polypeptide binding]; other site 1052585007368 putative active site [active] 1052585007369 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1052585007370 active site 1052585007371 homotetramer interface [polypeptide binding]; other site 1052585007372 homodimer interface [polypeptide binding]; other site 1052585007373 threonine synthase; Validated; Region: PRK06260 1052585007374 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1052585007375 homodimer interface [polypeptide binding]; other site 1052585007376 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585007377 catalytic residue [active] 1052585007378 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1052585007379 homotrimer interaction site [polypeptide binding]; other site 1052585007380 putative active site [active] 1052585007381 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1052585007382 YheO-like PAS domain; Region: PAS_6; pfam08348 1052585007383 Helix-turn-helix domains; Region: HTH; cl00088 1052585007384 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1052585007385 binding surface 1052585007386 TPR motif; other site 1052585007387 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052585007388 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052585007389 TPR repeat; Region: TPR_11; pfam13414 1052585007390 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1052585007391 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1052585007392 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1052585007393 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 1052585007394 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1052585007395 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1052585007396 Helix-turn-helix domains; Region: HTH; cl00088 1052585007397 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1052585007398 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1052585007399 CPxP motif; other site 1052585007400 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1052585007401 active site residue [active] 1052585007402 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052585007403 DsrE/DsrF-like family; Region: DrsE; cl00672 1052585007404 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1052585007405 CPxP motif; other site 1052585007406 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1052585007407 active site residue [active] 1052585007408 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1052585007409 active site residue [active] 1052585007410 DsrE/DsrF-like family; Region: DrsE; cl00672 1052585007411 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052585007412 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1052585007413 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1052585007414 active site residue [active] 1052585007415 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1052585007416 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585007417 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052585007418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585007419 active site 1052585007420 phosphorylation site [posttranslational modification] 1052585007421 intermolecular recognition site; other site 1052585007422 dimerization interface [polypeptide binding]; other site 1052585007423 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052585007424 DNA binding residues [nucleotide binding] 1052585007425 dimerization interface [polypeptide binding]; other site 1052585007426 PAS domain S-box; Region: sensory_box; TIGR00229 1052585007427 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1052585007428 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1052585007429 Histidine kinase; Region: HisKA_3; pfam07730 1052585007430 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585007431 ATP binding site [chemical binding]; other site 1052585007432 Mg2+ binding site [ion binding]; other site 1052585007433 G-X-G motif; other site 1052585007434 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 1052585007435 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1052585007436 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1052585007437 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052585007438 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1052585007439 CAT RNA binding domain; Region: CAT_RBD; cl03904 1052585007440 PRD domain; Region: PRD; cl15445 1052585007441 PRD domain; Region: PRD; cl15445 1052585007442 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1052585007443 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1052585007444 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052585007445 active site turn [active] 1052585007446 phosphorylation site [posttranslational modification] 1052585007447 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1052585007448 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 1052585007449 HPr interaction site; other site 1052585007450 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1052585007451 active site 1052585007452 phosphorylation site [posttranslational modification] 1052585007453 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1052585007454 metal-binding site [ion binding] 1052585007455 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1052585007456 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1052585007457 metal-binding site [ion binding] 1052585007458 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1052585007459 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1052585007460 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1052585007461 metal-binding site [ion binding] 1052585007462 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 1052585007463 putative homotetramer interface [polypeptide binding]; other site 1052585007464 putative homodimer interface [polypeptide binding]; other site 1052585007465 allosteric switch controlling residues; other site 1052585007466 putative metal binding site [ion binding]; other site 1052585007467 putative homodimer-homodimer interface [polypeptide binding]; other site 1052585007468 DinB superfamily; Region: DinB_2; pfam12867 1052585007469 Cysteine dioxygenase type I; Region: CDO_I; cl15835 1052585007470 Domain of unknown function (DUF955); Region: DUF955; cl01076 1052585007471 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585007472 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1052585007473 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052585007474 putative DNA binding site [nucleotide binding]; other site 1052585007475 dimerization interface [polypeptide binding]; other site 1052585007476 putative Zn2+ binding site [ion binding]; other site 1052585007477 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1052585007478 dimer interface [polypeptide binding]; other site 1052585007479 FMN binding site [chemical binding]; other site 1052585007480 NADPH bind site [chemical binding]; other site 1052585007481 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 1052585007482 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1052585007483 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 1052585007484 DNA binding residues [nucleotide binding] 1052585007485 dimer interface [polypeptide binding]; other site 1052585007486 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1052585007487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585007488 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585007489 putative substrate translocation pore; other site 1052585007490 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052585007491 Transporter associated domain; Region: CorC_HlyC; cl08393 1052585007492 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1052585007493 Flavin Reductases; Region: FlaRed; cl00801 1052585007494 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1052585007495 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1052585007496 DNA binding residues [nucleotide binding] 1052585007497 drug binding residues [chemical binding]; other site 1052585007498 dimer interface [polypeptide binding]; other site 1052585007499 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1052585007500 Protein of unknown function (DUF419); Region: DUF419; cl15265 1052585007501 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1052585007502 active site 1052585007503 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 1052585007504 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 1052585007505 YodA lipocalin-like domain; Region: YodA; cl01365 1052585007506 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 1052585007507 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052585007508 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052585007509 DNA binding residues [nucleotide binding] 1052585007510 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1052585007511 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052585007512 active site 1052585007513 catalytic tetrad [active] 1052585007514 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 1052585007515 chitosan binding site [chemical binding]; other site 1052585007516 catalytic residues [active] 1052585007517 Mor transcription activator family; Region: Mor; cl02360 1052585007518 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052585007519 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052585007520 Bacterial SH3 domain; Region: SH3_3; cl02551 1052585007521 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 1052585007522 Bacterial SH3 domain; Region: SH3_3; cl02551 1052585007523 Coat F domain; Region: Coat_F; cl15836 1052585007524 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1052585007525 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1052585007526 NAD binding site [chemical binding]; other site 1052585007527 catalytic Zn binding site [ion binding]; other site 1052585007528 structural Zn binding site [ion binding]; other site 1052585007529 Coat F domain; Region: Coat_F; cl15836 1052585007530 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1052585007531 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052585007532 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1052585007533 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1052585007534 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1052585007535 DNA binding residues [nucleotide binding] 1052585007536 putative dimer interface [polypeptide binding]; other site 1052585007537 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1052585007538 Cupin domain; Region: Cupin_2; cl09118 1052585007539 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1052585007540 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1052585007541 putative NAD(P) binding site [chemical binding]; other site 1052585007542 putative substrate binding site [chemical binding]; other site 1052585007543 catalytic Zn binding site [ion binding]; other site 1052585007544 structural Zn binding site [ion binding]; other site 1052585007545 dimer interface [polypeptide binding]; other site 1052585007546 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1052585007547 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1052585007548 proposed catalytic triad [active] 1052585007549 conserved cys residue [active] 1052585007550 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1052585007551 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1052585007552 substrate binding [chemical binding]; other site 1052585007553 active site 1052585007554 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1052585007555 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 1052585007556 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 1052585007557 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 1052585007558 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1052585007559 active site 1052585007560 phosphorylation site [posttranslational modification] 1052585007561 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1052585007562 active pocket/dimerization site; other site 1052585007563 active site 1052585007564 phosphorylation site [posttranslational modification] 1052585007565 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1052585007566 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585007567 Walker A motif; other site 1052585007568 ATP binding site [chemical binding]; other site 1052585007569 Walker B motif; other site 1052585007570 arginine finger; other site 1052585007571 Transcriptional antiterminator [Transcription]; Region: COG3933 1052585007572 PRD domain; Region: PRD; cl15445 1052585007573 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1052585007574 active pocket/dimerization site; other site 1052585007575 active site 1052585007576 phosphorylation site [posttranslational modification] 1052585007577 PRD domain; Region: PRD; cl15445 1052585007578 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1052585007579 LysE type translocator; Region: LysE; cl00565 1052585007580 Predicted transcriptional regulators [Transcription]; Region: COG1378 1052585007581 Helix-turn-helix domains; Region: HTH; cl00088 1052585007582 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 1052585007583 C-terminal domain interface [polypeptide binding]; other site 1052585007584 sugar binding site [chemical binding]; other site 1052585007585 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1052585007586 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052585007587 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052585007588 DNA binding residues [nucleotide binding] 1052585007589 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1052585007590 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1052585007591 OpgC protein; Region: OpgC_C; cl00792 1052585007592 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1052585007593 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1052585007594 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1052585007595 catalytic triad [active] 1052585007596 catalytic triad [active] 1052585007597 oxyanion hole [active] 1052585007598 YrhK-like protein; Region: YrhK; pfam14145 1052585007599 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1052585007600 Cytochrome P450; Region: p450; pfam00067 1052585007601 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1052585007602 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1052585007603 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1052585007604 FAD binding pocket [chemical binding]; other site 1052585007605 FAD binding motif [chemical binding]; other site 1052585007606 catalytic residues [active] 1052585007607 NAD binding pocket [chemical binding]; other site 1052585007608 phosphate binding motif [ion binding]; other site 1052585007609 beta-alpha-beta structure motif; other site 1052585007610 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585007611 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585007612 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 1052585007613 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 1052585007614 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 1052585007615 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1052585007616 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1052585007617 catalytic loop [active] 1052585007618 iron binding site [ion binding]; other site 1052585007619 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 1052585007620 4Fe-4S binding domain; Region: Fer4; cl02805 1052585007621 4Fe-4S binding domain; Region: Fer4; cl02805 1052585007622 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1052585007623 [4Fe-4S] binding site [ion binding]; other site 1052585007624 molybdopterin cofactor binding site; other site 1052585007625 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1052585007626 molybdopterin cofactor binding site; other site 1052585007627 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 1052585007628 YrhC-like protein; Region: YrhC; pfam14143 1052585007629 cystathionine beta-lyase; Provisional; Region: PRK07671 1052585007630 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1052585007631 homodimer interface [polypeptide binding]; other site 1052585007632 substrate-cofactor binding pocket; other site 1052585007633 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585007634 catalytic residue [active] 1052585007635 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1052585007636 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1052585007637 dimer interface [polypeptide binding]; other site 1052585007638 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585007639 catalytic residue [active] 1052585007640 5'-methylthioadenosine nucleosidase; Region: PLN02584 1052585007641 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1052585007642 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1052585007643 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585007644 S-adenosylmethionine binding site [chemical binding]; other site 1052585007645 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 1052585007646 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1052585007647 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1052585007648 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1052585007649 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052585007650 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1052585007651 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1052585007652 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1052585007653 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1052585007654 ATP-binding site [chemical binding]; other site 1052585007655 Sugar specificity; other site 1052585007656 Pyrimidine base specificity; other site 1052585007657 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1052585007658 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 1052585007659 Peptidase family U32; Region: Peptidase_U32; cl03113 1052585007660 Peptidase family U32; Region: Peptidase_U32; cl03113 1052585007661 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1052585007662 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585007663 S-adenosylmethionine binding site [chemical binding]; other site 1052585007664 YceG-like family; Region: YceG; pfam02618 1052585007665 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1052585007666 dimerization interface [polypeptide binding]; other site 1052585007667 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 1052585007668 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 1052585007669 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 1052585007670 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1052585007671 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 1052585007672 motif 1; other site 1052585007673 active site 1052585007674 motif 2; other site 1052585007675 motif 3; other site 1052585007676 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 1052585007677 DHHA1 domain; Region: DHHA1; pfam02272 1052585007678 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1052585007679 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1052585007680 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 1052585007681 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 1052585007682 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1052585007683 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585007684 Family description; Region: UvrD_C_2; cl15862 1052585007685 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585007686 binding surface 1052585007687 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1052585007688 TPR motif; other site 1052585007689 TPR repeat; Region: TPR_11; pfam13414 1052585007690 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585007691 binding surface 1052585007692 TPR motif; other site 1052585007693 TPR repeat; Region: TPR_11; pfam13414 1052585007694 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1052585007695 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1052585007696 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1052585007697 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 1052585007698 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052585007699 catalytic residue [active] 1052585007700 Predicted transcriptional regulator [Transcription]; Region: COG1959 1052585007701 Helix-turn-helix domains; Region: HTH; cl00088 1052585007702 recombination factor protein RarA; Reviewed; Region: PRK13342 1052585007703 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585007704 Walker A motif; other site 1052585007705 ATP binding site [chemical binding]; other site 1052585007706 Walker B motif; other site 1052585007707 arginine finger; other site 1052585007708 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1052585007709 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1052585007710 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1052585007711 putative ATP binding site [chemical binding]; other site 1052585007712 putative substrate interface [chemical binding]; other site 1052585007713 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1052585007714 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1052585007715 dimer interface [polypeptide binding]; other site 1052585007716 anticodon binding site; other site 1052585007717 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 1052585007718 homodimer interface [polypeptide binding]; other site 1052585007719 motif 1; other site 1052585007720 active site 1052585007721 motif 2; other site 1052585007722 GAD domain; Region: GAD; pfam02938 1052585007723 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 1052585007724 motif 3; other site 1052585007725 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1052585007726 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 1052585007727 dimer interface [polypeptide binding]; other site 1052585007728 motif 1; other site 1052585007729 active site 1052585007730 motif 2; other site 1052585007731 motif 3; other site 1052585007732 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1052585007733 anticodon binding site; other site 1052585007734 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 1052585007735 Bacterial SH3 domain; Region: SH3_3; cl02551 1052585007736 Bacterial SH3 domain; Region: SH3_3; cl02551 1052585007737 Bacterial SH3 domain; Region: SH3_3; cl02551 1052585007738 Bacterial SH3 domain; Region: SH3_3; cl02551 1052585007739 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1052585007740 active site 1052585007741 metal binding site [ion binding]; metal-binding site 1052585007742 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1052585007743 putative active site [active] 1052585007744 dimerization interface [polypeptide binding]; other site 1052585007745 putative tRNAtyr binding site [nucleotide binding]; other site 1052585007746 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1052585007747 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1052585007748 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1052585007749 synthetase active site [active] 1052585007750 NTP binding site [chemical binding]; other site 1052585007751 metal binding site [ion binding]; metal-binding site 1052585007752 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1052585007753 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1052585007754 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 1052585007755 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052585007756 active site 1052585007757 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1052585007758 DHH family; Region: DHH; pfam01368 1052585007759 DHHA1 domain; Region: DHHA1; pfam02272 1052585007760 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 1052585007761 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 1052585007762 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1052585007763 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1052585007764 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1052585007765 Protein export membrane protein; Region: SecD_SecF; cl14618 1052585007766 Protein export membrane protein; Region: SecD_SecF; cl14618 1052585007767 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 1052585007768 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1052585007769 MatE; Region: MatE; cl10513 1052585007770 MatE; Region: MatE; cl10513 1052585007771 Protein of unknown function (DUF421); Region: DUF421; cl00990 1052585007772 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 1052585007773 Preprotein translocase subunit; Region: YajC; cl00806 1052585007774 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1052585007775 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 1052585007776 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1052585007777 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 1052585007778 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 1052585007779 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1052585007780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585007781 Walker A motif; other site 1052585007782 ATP binding site [chemical binding]; other site 1052585007783 Walker B motif; other site 1052585007784 arginine finger; other site 1052585007785 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1052585007786 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1052585007787 RuvA N terminal domain; Region: RuvA_N; pfam01330 1052585007788 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1052585007789 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 1052585007790 BofC C-terminal domain; Region: BofC_C; pfam08955 1052585007791 polyol permease family; Region: 2A0118; TIGR00897 1052585007792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585007793 putative substrate translocation pore; other site 1052585007794 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052585007795 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585007796 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1052585007797 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 1052585007798 active site 1052585007799 ATP binding site [chemical binding]; other site 1052585007800 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1052585007801 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1052585007802 Transcriptional regulator; Region: Transcrip_reg; cl00361 1052585007803 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1052585007804 invasion associated secreted endopeptidase; Provisional; Region: PRK13914 1052585007805 putative peptidoglycan binding site; other site 1052585007806 Quinolinate synthetase A protein; Region: NadA; cl00420 1052585007807 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 1052585007808 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1052585007809 dimerization interface [polypeptide binding]; other site 1052585007810 active site 1052585007811 L-aspartate oxidase; Provisional; Region: PRK08071 1052585007812 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585007813 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1052585007814 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1052585007815 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 1052585007816 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052585007817 catalytic residue [active] 1052585007818 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1052585007819 Helix-turn-helix domains; Region: HTH; cl00088 1052585007820 3H domain; Region: 3H; pfam02829 1052585007821 prephenate dehydratase; Provisional; Region: PRK11898 1052585007822 Prephenate dehydratase; Region: PDT; pfam00800 1052585007823 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1052585007824 putative L-Phe binding site [chemical binding]; other site 1052585007825 hypothetical protein; Provisional; Region: PRK04435 1052585007826 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 1052585007827 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1052585007828 GTP1/OBG; Region: GTP1_OBG; pfam01018 1052585007829 Obg GTPase; Region: Obg; cd01898 1052585007830 G1 box; other site 1052585007831 GTP/Mg2+ binding site [chemical binding]; other site 1052585007832 Switch I region; other site 1052585007833 G2 box; other site 1052585007834 G3 box; other site 1052585007835 Switch II region; other site 1052585007836 G4 box; other site 1052585007837 G5 box; other site 1052585007838 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 1052585007839 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1052585007840 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 1052585007841 Protein of unknown function (DUF464); Region: DUF464; cl01080 1052585007842 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 1052585007843 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 1052585007844 active site 1052585007845 putative substrate binding region [chemical binding]; other site 1052585007846 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1052585007847 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 1052585007848 septum site-determining protein MinD; Region: minD_bact; TIGR01968 1052585007849 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1052585007850 Switch I; other site 1052585007851 Switch II; other site 1052585007852 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1052585007853 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1052585007854 rod shape-determining protein MreD; Region: MreD; cl01087 1052585007855 rod shape-determining protein MreC; Region: mreC; TIGR00219 1052585007856 rod shape-determining protein MreC; Region: MreC; pfam04085 1052585007857 rod shape-determining protein MreB; Provisional; Region: PRK13927 1052585007858 Cell division protein FtsA; Region: FtsA; cl11496 1052585007859 hypothetical protein; Reviewed; Region: PRK00024 1052585007860 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1052585007861 MPN+ (JAMM) motif; other site 1052585007862 Zinc-binding site [ion binding]; other site 1052585007863 Maf-like protein; Region: Maf; pfam02545 1052585007864 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1052585007865 active site 1052585007866 dimer interface [polypeptide binding]; other site 1052585007867 Sporulation related domain; Region: SPOR; cl10051 1052585007868 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1052585007869 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 1052585007870 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1052585007871 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1052585007872 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1052585007873 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1052585007874 active site 1052585007875 HIGH motif; other site 1052585007876 nucleotide binding site [chemical binding]; other site 1052585007877 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1052585007878 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1052585007879 active site 1052585007880 KMSKS motif; other site 1052585007881 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1052585007882 tRNA binding surface [nucleotide binding]; other site 1052585007883 anticodon binding site; other site 1052585007884 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1052585007885 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052585007886 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 1052585007887 cell division protein ZipA; Provisional; Region: PRK03427 1052585007888 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 1052585007889 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 1052585007890 putative peptidoglycan binding site; other site 1052585007891 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1052585007892 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052585007893 inhibitor-cofactor binding pocket; inhibition site 1052585007894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585007895 catalytic residue [active] 1052585007896 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1052585007897 dimer interface [polypeptide binding]; other site 1052585007898 active site 1052585007899 Schiff base residues; other site 1052585007900 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1052585007901 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1052585007902 active site 1052585007903 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1052585007904 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1052585007905 domain interfaces; other site 1052585007906 active site 1052585007907 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1052585007908 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1052585007909 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1052585007910 tRNA; other site 1052585007911 putative tRNA binding site [nucleotide binding]; other site 1052585007912 putative NADP binding site [chemical binding]; other site 1052585007913 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1052585007914 Predicted GTPase [General function prediction only]; Region: COG0218 1052585007915 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1052585007916 G1 box; other site 1052585007917 GTP/Mg2+ binding site [chemical binding]; other site 1052585007918 Switch I region; other site 1052585007919 G2 box; other site 1052585007920 G3 box; other site 1052585007921 Switch II region; other site 1052585007922 G4 box; other site 1052585007923 G5 box; other site 1052585007924 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1052585007925 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1052585007926 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1052585007927 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585007928 Walker A motif; other site 1052585007929 ATP binding site [chemical binding]; other site 1052585007930 Walker B motif; other site 1052585007931 arginine finger; other site 1052585007932 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1052585007933 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 1052585007934 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585007935 Walker A motif; other site 1052585007936 ATP binding site [chemical binding]; other site 1052585007937 Walker B motif; other site 1052585007938 arginine finger; other site 1052585007939 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 1052585007940 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1052585007941 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 1052585007942 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585007943 Walker A motif; other site 1052585007944 ATP binding site [chemical binding]; other site 1052585007945 Walker B motif; other site 1052585007946 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1052585007947 trigger factor; Provisional; Region: tig; PRK01490 1052585007948 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 1052585007949 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1052585007950 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585007951 binding surface 1052585007952 TPR motif; other site 1052585007953 ApbE family; Region: ApbE; cl00643 1052585007954 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1052585007955 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1052585007956 substrate binding site [chemical binding]; other site 1052585007957 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1052585007958 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1052585007959 substrate binding site [chemical binding]; other site 1052585007960 ligand binding site [chemical binding]; other site 1052585007961 tartrate dehydrogenase; Provisional; Region: PRK08194 1052585007962 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1052585007963 2-isopropylmalate synthase; Validated; Region: PRK00915 1052585007964 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1052585007965 active site 1052585007966 metal binding site [ion binding]; metal-binding site 1052585007967 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 1052585007968 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1052585007969 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585007970 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1052585007971 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1052585007972 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1052585007973 putative valine binding site [chemical binding]; other site 1052585007974 dimer interface [polypeptide binding]; other site 1052585007975 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1052585007976 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 1052585007977 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1052585007978 PYR/PP interface [polypeptide binding]; other site 1052585007979 dimer interface [polypeptide binding]; other site 1052585007980 TPP binding site [chemical binding]; other site 1052585007981 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1052585007982 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1052585007983 TPP-binding site [chemical binding]; other site 1052585007984 dimer interface [polypeptide binding]; other site 1052585007985 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1052585007986 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585007987 Coenzyme A binding pocket [chemical binding]; other site 1052585007988 Heat induced stress protein YflT; Region: YflT; pfam11181 1052585007989 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 1052585007990 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1052585007991 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1052585007992 active site 1052585007993 metal binding site [ion binding]; metal-binding site 1052585007994 homotetramer interface [polypeptide binding]; other site 1052585007995 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1052585007996 active site 1052585007997 dimerization interface [polypeptide binding]; other site 1052585007998 ribonuclease PH; Reviewed; Region: rph; PRK00173 1052585007999 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1052585008000 hexamer interface [polypeptide binding]; other site 1052585008001 active site 1052585008002 Spore germination protein [General function prediction only]; Region: COG5401 1052585008003 Sporulation and spore germination; Region: Germane; cl11253 1052585008004 Sporulation and spore germination; Region: Germane; cl11253 1052585008005 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1052585008006 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585008007 Helix-turn-helix domains; Region: HTH; cl00088 1052585008008 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052585008009 DNA binding residues [nucleotide binding] 1052585008010 dimerization interface [polypeptide binding]; other site 1052585008011 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1052585008012 active site 1052585008013 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1052585008014 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1052585008015 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1052585008016 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1052585008017 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585008018 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1052585008019 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1052585008020 putative Iron-sulfur protein interface [polypeptide binding]; other site 1052585008021 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1052585008022 proximal heme binding site [chemical binding]; other site 1052585008023 distal heme binding site [chemical binding]; other site 1052585008024 putative dimer interface [polypeptide binding]; other site 1052585008025 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1052585008026 aspartate kinase; Reviewed; Region: PRK06635 1052585008027 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1052585008028 putative nucleotide binding site [chemical binding]; other site 1052585008029 putative catalytic residues [active] 1052585008030 putative Mg ion binding site [ion binding]; other site 1052585008031 putative aspartate binding site [chemical binding]; other site 1052585008032 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1052585008033 putative allosteric regulatory site; other site 1052585008034 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 1052585008035 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1052585008036 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1052585008037 GIY-YIG motif/motif A; other site 1052585008038 active site 1052585008039 catalytic site [active] 1052585008040 putative DNA binding site [nucleotide binding]; other site 1052585008041 metal binding site [ion binding]; metal-binding site 1052585008042 UvrB/uvrC motif; Region: UVR; pfam02151 1052585008043 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1052585008044 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1052585008045 catalytic residues [active] 1052585008046 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1052585008047 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 1052585008048 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1052585008049 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1052585008050 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1052585008051 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1052585008052 Ligand binding site [chemical binding]; other site 1052585008053 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1052585008054 enoyl-CoA hydratase; Provisional; Region: PRK07658 1052585008055 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1052585008056 substrate binding site [chemical binding]; other site 1052585008057 oxyanion hole (OAH) forming residues; other site 1052585008058 trimer interface [polypeptide binding]; other site 1052585008059 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585008060 Helix-turn-helix domains; Region: HTH; cl00088 1052585008061 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1052585008062 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 1052585008063 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585008064 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052585008065 Predicted membrane protein [Function unknown]; Region: COG3766 1052585008066 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1052585008067 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1052585008068 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1052585008069 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 1052585008070 Walker A/P-loop; other site 1052585008071 ATP binding site [chemical binding]; other site 1052585008072 Q-loop/lid; other site 1052585008073 ABC transporter signature motif; other site 1052585008074 Walker B; other site 1052585008075 D-loop; other site 1052585008076 H-loop/switch region; other site 1052585008077 Plant ATP synthase F0; Region: YMF19; cl07975 1052585008078 Smr domain; Region: Smr; cl02619 1052585008079 hypothetical protein; Provisional; Region: PRK08609 1052585008080 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1052585008081 active site 1052585008082 primer binding site [nucleotide binding]; other site 1052585008083 NTP binding site [chemical binding]; other site 1052585008084 metal binding triad [ion binding]; metal-binding site 1052585008085 Colicin V production protein; Region: Colicin_V; cl00567 1052585008086 Cell division protein ZapA; Region: ZapA; cl01146 1052585008087 ribonuclease HIII; Provisional; Region: PRK00996 1052585008088 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1052585008089 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1052585008090 RNA/DNA hybrid binding site [nucleotide binding]; other site 1052585008091 active site 1052585008092 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1052585008093 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1052585008094 putative tRNA-binding site [nucleotide binding]; other site 1052585008095 B3/4 domain; Region: B3_4; cl11458 1052585008096 tRNA synthetase B5 domain; Region: B5; cl08394 1052585008097 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1052585008098 dimer interface [polypeptide binding]; other site 1052585008099 motif 1; other site 1052585008100 motif 3; other site 1052585008101 motif 2; other site 1052585008102 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 1052585008103 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1052585008104 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1052585008105 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1052585008106 dimer interface [polypeptide binding]; other site 1052585008107 motif 1; other site 1052585008108 active site 1052585008109 motif 2; other site 1052585008110 motif 3; other site 1052585008111 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1052585008112 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 1052585008113 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 1052585008114 Small, acid-soluble spore protein I; Region: SSPI; cl07940 1052585008115 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1052585008116 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1052585008117 Helix-turn-helix domains; Region: HTH; cl00088 1052585008118 FAD binding domain; Region: FAD_binding_4; pfam01565 1052585008119 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1052585008120 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1052585008121 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1052585008122 Cysteine-rich domain; Region: CCG; pfam02754 1052585008123 Cysteine-rich domain; Region: CCG; pfam02754 1052585008124 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1052585008125 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052585008126 active site 1052585008127 metal binding site [ion binding]; metal-binding site 1052585008128 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1052585008129 Carbon starvation protein CstA; Region: CstA; pfam02554 1052585008130 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1052585008131 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1052585008132 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1052585008133 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 1052585008134 Helix-turn-helix domains; Region: HTH; cl00088 1052585008135 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1052585008136 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 1052585008137 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052585008138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585008139 putative PBP binding loops; other site 1052585008140 dimer interface [polypeptide binding]; other site 1052585008141 ABC-ATPase subunit interface; other site 1052585008142 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052585008143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585008144 dimer interface [polypeptide binding]; other site 1052585008145 conserved gate region; other site 1052585008146 putative PBP binding loops; other site 1052585008147 ABC-ATPase subunit interface; other site 1052585008148 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052585008149 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1052585008150 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1052585008151 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1052585008152 active site 1052585008153 metal binding site [ion binding]; metal-binding site 1052585008154 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1052585008155 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585008156 active site 1052585008157 motif I; other site 1052585008158 motif II; other site 1052585008159 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585008160 motif II; other site 1052585008161 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1052585008162 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1052585008163 intersubunit interface [polypeptide binding]; other site 1052585008164 active site 1052585008165 Zn2+ binding site [ion binding]; other site 1052585008166 L-ribulokinase; Region: L-ribulokinase; TIGR01234 1052585008167 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1052585008168 putative N- and C-terminal domain interface [polypeptide binding]; other site 1052585008169 putative active site [active] 1052585008170 putative MgATP binding site [chemical binding]; other site 1052585008171 catalytic site [active] 1052585008172 metal binding site [ion binding]; metal-binding site 1052585008173 carbohydrate binding site [chemical binding]; other site 1052585008174 homodimer interface [polypeptide binding]; other site 1052585008175 L-arabinose isomerase; Provisional; Region: PRK02929 1052585008176 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1052585008177 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1052585008178 trimer interface [polypeptide binding]; other site 1052585008179 putative substrate binding site [chemical binding]; other site 1052585008180 putative metal binding site [ion binding]; other site 1052585008181 Glycosyl hydrolase family 43; Region: GH43_ABN; cd08988 1052585008182 substrate binding site [chemical binding]; other site 1052585008183 active site 1052585008184 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1052585008185 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1052585008186 oligomer interface [polypeptide binding]; other site 1052585008187 active site 1052585008188 metal binding site [ion binding]; metal-binding site 1052585008189 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 1052585008190 ribosomal protein L20; Region: rpl20; CHL00068 1052585008191 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1052585008192 23S rRNA binding site [nucleotide binding]; other site 1052585008193 L21 binding site [polypeptide binding]; other site 1052585008194 L13 binding site [polypeptide binding]; other site 1052585008195 translation initiation factor IF-3; Region: infC; TIGR00168 1052585008196 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1052585008197 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1052585008198 LrgB-like family; Region: LrgB; cl00596 1052585008199 LrgA family; Region: LrgA; cl00608 1052585008200 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1052585008201 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585008202 active site 1052585008203 phosphorylation site [posttranslational modification] 1052585008204 intermolecular recognition site; other site 1052585008205 dimerization interface [polypeptide binding]; other site 1052585008206 LytTr DNA-binding domain; Region: LytTR; cl04498 1052585008207 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1052585008208 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 1052585008209 GAF domain; Region: GAF; cl15785 1052585008210 Histidine kinase; Region: His_kinase; pfam06580 1052585008211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585008212 ATP binding site [chemical binding]; other site 1052585008213 Mg2+ binding site [ion binding]; other site 1052585008214 G-X-G motif; other site 1052585008215 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1052585008216 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585008217 motif II; other site 1052585008218 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1052585008219 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1052585008220 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 1052585008221 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1052585008222 active site 1052585008223 dimer interface [polypeptide binding]; other site 1052585008224 motif 1; other site 1052585008225 motif 2; other site 1052585008226 motif 3; other site 1052585008227 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1052585008228 anticodon binding site; other site 1052585008229 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1052585008230 primosomal protein DnaI; Reviewed; Region: PRK08939 1052585008231 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1052585008232 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585008233 Walker A motif; other site 1052585008234 ATP binding site [chemical binding]; other site 1052585008235 Walker B motif; other site 1052585008236 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1052585008237 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 1052585008238 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1052585008239 ATP cone domain; Region: ATP-cone; pfam03477 1052585008240 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 1052585008241 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 1052585008242 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585008243 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1052585008244 Helix-turn-helix domains; Region: HTH; cl00088 1052585008245 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052585008246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585008247 putative substrate translocation pore; other site 1052585008248 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052585008249 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052585008250 active site 1052585008251 catalytic tetrad [active] 1052585008252 dephospho-CoA kinase; Region: TIGR00152 1052585008253 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1052585008254 CoA-binding site [chemical binding]; other site 1052585008255 ATP-binding [chemical binding]; other site 1052585008256 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1052585008257 Domain of unknown function DUF; Region: DUF204; pfam02659 1052585008258 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1052585008259 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1052585008260 DNA binding site [nucleotide binding] 1052585008261 catalytic residue [active] 1052585008262 H2TH interface [polypeptide binding]; other site 1052585008263 putative catalytic residues [active] 1052585008264 turnover-facilitating residue; other site 1052585008265 intercalation triad [nucleotide binding]; other site 1052585008266 8OG recognition residue [nucleotide binding]; other site 1052585008267 putative reading head residues; other site 1052585008268 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1052585008269 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1052585008270 DNA polymerase I; Provisional; Region: PRK05755 1052585008271 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1052585008272 active site 1052585008273 metal binding site 1 [ion binding]; metal-binding site 1052585008274 putative 5' ssDNA interaction site; other site 1052585008275 metal binding site 3; metal-binding site 1052585008276 metal binding site 2 [ion binding]; metal-binding site 1052585008277 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1052585008278 putative DNA binding site [nucleotide binding]; other site 1052585008279 putative metal binding site [ion binding]; other site 1052585008280 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1052585008281 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1052585008282 active site 1052585008283 DNA binding site [nucleotide binding] 1052585008284 catalytic site [active] 1052585008285 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1052585008286 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1052585008287 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052585008288 dimer interface [polypeptide binding]; other site 1052585008289 phosphorylation site [posttranslational modification] 1052585008290 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585008291 ATP binding site [chemical binding]; other site 1052585008292 Mg2+ binding site [ion binding]; other site 1052585008293 G-X-G motif; other site 1052585008294 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052585008295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585008296 active site 1052585008297 phosphorylation site [posttranslational modification] 1052585008298 intermolecular recognition site; other site 1052585008299 dimerization interface [polypeptide binding]; other site 1052585008300 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052585008301 DNA binding site [nucleotide binding] 1052585008302 malate dehydrogenase; Reviewed; Region: PRK06223 1052585008303 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1052585008304 NAD(P) binding site [chemical binding]; other site 1052585008305 dimer interface [polypeptide binding]; other site 1052585008306 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052585008307 substrate binding site [chemical binding]; other site 1052585008308 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1052585008309 isocitrate dehydrogenase; Validated; Region: PRK07362 1052585008310 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1052585008311 dimer interface [polypeptide binding]; other site 1052585008312 Citrate synthase; Region: Citrate_synt; pfam00285 1052585008313 active site 1052585008314 citrylCoA binding site [chemical binding]; other site 1052585008315 oxalacetate/citrate binding site [chemical binding]; other site 1052585008316 coenzyme A binding site [chemical binding]; other site 1052585008317 catalytic triad [active] 1052585008318 Protein of unknown function (DUF441); Region: DUF441; cl01041 1052585008319 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1052585008320 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1052585008321 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 1052585008322 pyruvate kinase; Provisional; Region: PRK06354 1052585008323 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 1052585008324 active site 1052585008325 domain interfaces; other site 1052585008326 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1052585008327 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1052585008328 active site 1052585008329 ADP/pyrophosphate binding site [chemical binding]; other site 1052585008330 dimerization interface [polypeptide binding]; other site 1052585008331 allosteric effector site; other site 1052585008332 fructose-1,6-bisphosphate binding site; other site 1052585008333 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1052585008334 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1052585008335 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1052585008336 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1052585008337 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 1052585008338 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1052585008339 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1052585008340 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1052585008341 putative NAD(P) binding site [chemical binding]; other site 1052585008342 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 1052585008343 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 1052585008344 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1052585008345 generic binding surface I; other site 1052585008346 generic binding surface II; other site 1052585008347 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 1052585008348 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1052585008349 DHH family; Region: DHH; pfam01368 1052585008350 DHHA1 domain; Region: DHHA1; pfam02272 1052585008351 YtpI-like protein; Region: YtpI; pfam14007 1052585008352 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1052585008353 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585008354 DNA-binding site [nucleotide binding]; DNA binding site 1052585008355 DRTGG domain; Region: DRTGG; cl12147 1052585008356 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1052585008357 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1052585008358 active site 2 [active] 1052585008359 active site 1 [active] 1052585008360 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052585008361 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1052585008362 classical (c) SDRs; Region: SDR_c; cd05233 1052585008363 NAD(P) binding site [chemical binding]; other site 1052585008364 active site 1052585008365 argininosuccinate lyase; Provisional; Region: PRK00855 1052585008366 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1052585008367 active sites [active] 1052585008368 tetramer interface [polypeptide binding]; other site 1052585008369 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 1052585008370 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1052585008371 ANP binding site [chemical binding]; other site 1052585008372 Substrate Binding Site II [chemical binding]; other site 1052585008373 Substrate Binding Site I [chemical binding]; other site 1052585008374 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1052585008375 MPT binding site; other site 1052585008376 trimer interface [polypeptide binding]; other site 1052585008377 Acetokinase family; Region: Acetate_kinase; cl01029 1052585008378 propionate/acetate kinase; Provisional; Region: PRK12379 1052585008379 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1052585008380 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585008381 S-adenosylmethionine binding site [chemical binding]; other site 1052585008382 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1052585008383 dimer interface [polypeptide binding]; other site 1052585008384 catalytic triad [active] 1052585008385 peroxidatic and resolving cysteines [active] 1052585008386 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 1052585008387 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 1052585008388 RDD family; Region: RDD; cl00746 1052585008389 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1052585008390 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1052585008391 tandem repeat interface [polypeptide binding]; other site 1052585008392 oligomer interface [polypeptide binding]; other site 1052585008393 active site residues [active] 1052585008394 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1052585008395 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1052585008396 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1052585008397 active site 1052585008398 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1052585008399 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585008400 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052585008401 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1052585008402 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1052585008403 THUMP domain; Region: THUMP; cl12076 1052585008404 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1052585008405 Ligand Binding Site [chemical binding]; other site 1052585008406 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 1052585008407 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1052585008408 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052585008409 catalytic residue [active] 1052585008410 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1052585008411 septation ring formation regulator EzrA; Provisional; Region: PRK04778 1052585008412 histidinol-phosphatase; Reviewed; Region: PRK08123 1052585008413 PHP-associated; Region: PHP_C; pfam13263 1052585008414 Helix-turn-helix domains; Region: HTH; cl00088 1052585008415 GAF domain; Region: GAF; cl15785 1052585008416 GAF domain; Region: GAF; cl15785 1052585008417 GAF domain; Region: GAF; cl15785 1052585008418 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1052585008419 metal binding site [ion binding]; metal-binding site 1052585008420 active site 1052585008421 I-site; other site 1052585008422 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1052585008423 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1052585008424 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052585008425 RNA binding surface [nucleotide binding]; other site 1052585008426 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1052585008427 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 1052585008428 active site 1052585008429 HIGH motif; other site 1052585008430 dimer interface [polypeptide binding]; other site 1052585008431 KMSKS motif; other site 1052585008432 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052585008433 RNA binding surface [nucleotide binding]; other site 1052585008434 acetyl-CoA synthetase; Provisional; Region: PRK04319 1052585008435 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1052585008436 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585008437 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052585008438 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052585008439 FOG: CBS domain [General function prediction only]; Region: COG0517 1052585008440 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 1052585008441 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 1052585008442 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1052585008443 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 1052585008444 flagellar motor protein MotS; Reviewed; Region: PRK06925 1052585008445 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1052585008446 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1052585008447 ligand binding site [chemical binding]; other site 1052585008448 flagellar motor protein MotP; Reviewed; Region: PRK06926 1052585008449 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1052585008450 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1052585008451 dimerization interface [polypeptide binding]; other site 1052585008452 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1052585008453 effector binding site; other site 1052585008454 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1052585008455 Chorismate mutase type II; Region: CM_2; cl00693 1052585008456 NeuB family; Region: NeuB; cl00496 1052585008457 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1052585008458 YtxH-like protein; Region: YtxH; cl02079 1052585008459 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 1052585008460 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1052585008461 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1052585008462 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1052585008463 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1052585008464 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1052585008465 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585008466 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 1052585008467 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1052585008468 putative tRNA-binding site [nucleotide binding]; other site 1052585008469 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 1052585008470 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1052585008471 catalytic residues [active] 1052585008472 Protein of unknown function (DUF2872); Region: DUF2872; cl11924 1052585008473 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1052585008474 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1052585008475 oligomer interface [polypeptide binding]; other site 1052585008476 active site 1052585008477 metal binding site [ion binding]; metal-binding site 1052585008478 Predicted small secreted protein [Function unknown]; Region: COG5584 1052585008479 malate dehydrogenase; Provisional; Region: PRK13529 1052585008480 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1052585008481 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1052585008482 NAD(P) binding site [chemical binding]; other site 1052585008483 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1052585008484 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052585008485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585008486 S-adenosylmethionine binding site [chemical binding]; other site 1052585008487 YtzH-like protein; Region: YtzH; pfam14165 1052585008488 Phosphotransferase enzyme family; Region: APH; pfam01636 1052585008489 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 1052585008490 substrate binding site [chemical binding]; other site 1052585008491 pullulanase, type I; Region: pulA_typeI; TIGR02104 1052585008492 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1052585008493 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1052585008494 Ca binding site [ion binding]; other site 1052585008495 active site 1052585008496 catalytic site [active] 1052585008497 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 1052585008498 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 1052585008499 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1052585008500 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1052585008501 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1052585008502 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1052585008503 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1052585008504 dimer interface [polypeptide binding]; other site 1052585008505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585008506 catalytic residue [active] 1052585008507 dipeptidase PepV; Reviewed; Region: PRK07318 1052585008508 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1052585008509 active site 1052585008510 metal binding site [ion binding]; metal-binding site 1052585008511 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1052585008512 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 1052585008513 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1052585008514 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1052585008515 Walker A/P-loop; other site 1052585008516 ATP binding site [chemical binding]; other site 1052585008517 Q-loop/lid; other site 1052585008518 ABC transporter signature motif; other site 1052585008519 Walker B; other site 1052585008520 D-loop; other site 1052585008521 H-loop/switch region; other site 1052585008522 Helix-turn-helix domains; Region: HTH; cl00088 1052585008523 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1052585008524 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 1052585008525 active site 1052585008526 uracil binding [chemical binding]; other site 1052585008527 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1052585008528 MatE; Region: MatE; cl10513 1052585008529 MatE; Region: MatE; cl10513 1052585008530 HI0933-like protein; Region: HI0933_like; pfam03486 1052585008531 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585008532 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585008533 BCCT family transporter; Region: BCCT; cl00569 1052585008534 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 1052585008535 Protein of unknown function, DUF624; Region: DUF624; cl02369 1052585008536 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585008537 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1052585008538 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1052585008539 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052585008540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1052585008541 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1052585008542 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052585008543 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052585008544 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052585008545 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052585008546 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052585008547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585008548 dimer interface [polypeptide binding]; other site 1052585008549 conserved gate region; other site 1052585008550 putative PBP binding loops; other site 1052585008551 ABC-ATPase subunit interface; other site 1052585008552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585008553 NAD(P) binding site [chemical binding]; other site 1052585008554 active site 1052585008555 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1052585008556 biotin synthase; Validated; Region: PRK06256 1052585008557 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052585008558 FeS/SAM binding site; other site 1052585008559 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 1052585008560 AAA domain; Region: AAA_26; pfam13500 1052585008561 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 1052585008562 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1052585008563 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1052585008564 substrate-cofactor binding pocket; other site 1052585008565 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585008566 catalytic residue [active] 1052585008567 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 1052585008568 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052585008569 inhibitor-cofactor binding pocket; inhibition site 1052585008570 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585008571 catalytic residue [active] 1052585008572 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 1052585008573 6-carboxyhexanoate--CoA ligase; Region: BioW; cl00625 1052585008574 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052585008575 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 1052585008576 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052585008577 DNA binding site [nucleotide binding] 1052585008578 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1052585008579 putative ligand binding site [chemical binding]; other site 1052585008580 putative dimerization interface [polypeptide binding]; other site 1052585008581 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052585008582 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1052585008583 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052585008584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585008585 dimer interface [polypeptide binding]; other site 1052585008586 conserved gate region; other site 1052585008587 putative PBP binding loops; other site 1052585008588 ABC-ATPase subunit interface; other site 1052585008589 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052585008590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585008591 dimer interface [polypeptide binding]; other site 1052585008592 conserved gate region; other site 1052585008593 putative PBP binding loops; other site 1052585008594 ABC-ATPase subunit interface; other site 1052585008595 alpha-galactosidase; Provisional; Region: PRK15076 1052585008596 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1052585008597 NAD binding site [chemical binding]; other site 1052585008598 sugar binding site [chemical binding]; other site 1052585008599 divalent metal binding site [ion binding]; other site 1052585008600 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052585008601 dimer interface [polypeptide binding]; other site 1052585008602 Helix-turn-helix domains; Region: HTH; cl00088 1052585008603 putative transposase OrfB; Reviewed; Region: PHA02517 1052585008604 HTH-like domain; Region: HTH_21; pfam13276 1052585008605 Integrase core domain; Region: rve; cl01316 1052585008606 Integrase core domain; Region: rve_3; cl15866 1052585008607 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1052585008608 active site residue [active] 1052585008609 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1052585008610 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1052585008611 HIGH motif; other site 1052585008612 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1052585008613 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1052585008614 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1052585008615 active site 1052585008616 KMSKS motif; other site 1052585008617 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1052585008618 tRNA binding surface [nucleotide binding]; other site 1052585008619 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 1052585008620 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052585008621 PAS domain; Region: PAS_9; pfam13426 1052585008622 putative active site [active] 1052585008623 heme pocket [chemical binding]; other site 1052585008624 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1052585008625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585008626 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585008627 putative substrate translocation pore; other site 1052585008628 MatE; Region: MatE; cl10513 1052585008629 Centromere protein H (CENP-H); Region: CENP-H; pfam05837 1052585008630 FtsX-like permease family; Region: FtsX; cl15850 1052585008631 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052585008632 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1052585008633 Walker A/P-loop; other site 1052585008634 ATP binding site [chemical binding]; other site 1052585008635 Q-loop/lid; other site 1052585008636 ABC transporter signature motif; other site 1052585008637 Walker B; other site 1052585008638 D-loop; other site 1052585008639 H-loop/switch region; other site 1052585008640 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052585008641 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585008642 ATP binding site [chemical binding]; other site 1052585008643 Mg2+ binding site [ion binding]; other site 1052585008644 G-X-G motif; other site 1052585008645 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052585008646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585008647 active site 1052585008648 phosphorylation site [posttranslational modification] 1052585008649 intermolecular recognition site; other site 1052585008650 dimerization interface [polypeptide binding]; other site 1052585008651 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052585008652 DNA binding site [nucleotide binding] 1052585008653 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1052585008654 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1052585008655 FtsX-like permease family; Region: FtsX; cl15850 1052585008656 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052585008657 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1052585008658 Walker A/P-loop; other site 1052585008659 ATP binding site [chemical binding]; other site 1052585008660 Q-loop/lid; other site 1052585008661 ABC transporter signature motif; other site 1052585008662 Walker B; other site 1052585008663 D-loop; other site 1052585008664 H-loop/switch region; other site 1052585008665 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1052585008666 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052585008667 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1052585008668 Walker A/P-loop; other site 1052585008669 ATP binding site [chemical binding]; other site 1052585008670 Q-loop/lid; other site 1052585008671 ABC transporter signature motif; other site 1052585008672 Walker B; other site 1052585008673 D-loop; other site 1052585008674 H-loop/switch region; other site 1052585008675 Predicted transcriptional regulators [Transcription]; Region: COG1725 1052585008676 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585008677 DNA-binding site [nucleotide binding]; DNA binding site 1052585008678 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 1052585008679 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1052585008680 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585008681 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585008682 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 1052585008683 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1052585008684 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052585008685 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052585008686 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1052585008687 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1052585008688 trimer interface [polypeptide binding]; other site 1052585008689 putative metal binding site [ion binding]; other site 1052585008690 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1052585008691 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1052585008692 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1052585008693 active site 1052585008694 dimer interface [polypeptide binding]; other site 1052585008695 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1052585008696 Ligand Binding Site [chemical binding]; other site 1052585008697 Molecular Tunnel; other site 1052585008698 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1052585008699 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1052585008700 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1052585008701 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1052585008702 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1052585008703 active site 1052585008704 substrate-binding site [chemical binding]; other site 1052585008705 metal-binding site [ion binding] 1052585008706 ATP binding site [chemical binding]; other site 1052585008707 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 1052585008708 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052585008709 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1052585008710 NMT1-like family; Region: NMT1_2; cl15260 1052585008711 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1052585008712 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 1052585008713 Walker A/P-loop; other site 1052585008714 ATP binding site [chemical binding]; other site 1052585008715 Q-loop/lid; other site 1052585008716 ABC transporter signature motif; other site 1052585008717 Walker B; other site 1052585008718 D-loop; other site 1052585008719 H-loop/switch region; other site 1052585008720 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1052585008721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585008722 dimer interface [polypeptide binding]; other site 1052585008723 conserved gate region; other site 1052585008724 putative PBP binding loops; other site 1052585008725 ABC-ATPase subunit interface; other site 1052585008726 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1052585008727 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1052585008728 nudix motif; other site 1052585008729 Holin family; Region: Phage_holin_4; cl01989 1052585008730 Ferritin-like domain; Region: Ferritin; pfam00210 1052585008731 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1052585008732 dimerization interface [polypeptide binding]; other site 1052585008733 DPS ferroxidase diiron center [ion binding]; other site 1052585008734 ion pore; other site 1052585008735 FixH; Region: FixH; cl01254 1052585008736 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 1052585008737 Haemolytic domain; Region: Haemolytic; cl00506 1052585008738 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1052585008739 active site clefts [active] 1052585008740 zinc binding site [ion binding]; other site 1052585008741 dimer interface [polypeptide binding]; other site 1052585008742 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 1052585008743 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1052585008744 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1052585008745 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1052585008746 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052585008747 ABC-ATPase subunit interface; other site 1052585008748 dimer interface [polypeptide binding]; other site 1052585008749 putative PBP binding regions; other site 1052585008750 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052585008751 ABC-ATPase subunit interface; other site 1052585008752 dimer interface [polypeptide binding]; other site 1052585008753 putative PBP binding regions; other site 1052585008754 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1052585008755 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 1052585008756 Metal binding protein TroA. These proteins have been shown to function as initial receptors in ABC transport of Zn2+ and possibly Fe3+ in many eubacterial species. The TroA proteins belong to the TroA superfamily of periplasmic metal binding proteins...; Region: TroA; cd01016 1052585008757 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1052585008758 metal binding site [ion binding]; metal-binding site 1052585008759 intersubunit interface [polypeptide binding]; other site 1052585008760 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1052585008761 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1052585008762 active site 1052585008763 octamer interface [polypeptide binding]; other site 1052585008764 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 1052585008765 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585008766 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585008767 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1052585008768 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1052585008769 substrate binding site [chemical binding]; other site 1052585008770 oxyanion hole (OAH) forming residues; other site 1052585008771 trimer interface [polypeptide binding]; other site 1052585008772 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1052585008773 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052585008774 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1052585008775 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1052585008776 dimer interface [polypeptide binding]; other site 1052585008777 tetramer interface [polypeptide binding]; other site 1052585008778 PYR/PP interface [polypeptide binding]; other site 1052585008779 TPP binding site [chemical binding]; other site 1052585008780 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1052585008781 TPP-binding site; other site 1052585008782 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 1052585008783 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1052585008784 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1052585008785 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1052585008786 active site 1052585008787 tetramer interface; other site 1052585008788 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 1052585008789 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585008790 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1052585008791 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585008792 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1052585008793 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585008794 NAD(P) binding site [chemical binding]; other site 1052585008795 active site 1052585008796 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1052585008797 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052585008798 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1052585008799 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052585008800 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052585008801 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1052585008802 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 1052585008803 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052585008804 active site 1052585008805 ATP binding site [chemical binding]; other site 1052585008806 substrate binding site [chemical binding]; other site 1052585008807 TspO/MBR family; Region: TspO_MBR; cl01379 1052585008808 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1052585008809 homodimer interface [polypeptide binding]; other site 1052585008810 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1052585008811 active site pocket [active] 1052585008812 glycogen synthase; Provisional; Region: glgA; PRK00654 1052585008813 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1052585008814 ADP-binding pocket [chemical binding]; other site 1052585008815 homodimer interface [polypeptide binding]; other site 1052585008816 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 1052585008817 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1052585008818 ligand binding site; other site 1052585008819 oligomer interface; other site 1052585008820 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1052585008821 dimer interface [polypeptide binding]; other site 1052585008822 N-terminal domain interface [polypeptide binding]; other site 1052585008823 sulfate 1 binding site; other site 1052585008824 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 1052585008825 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1052585008826 ligand binding site; other site 1052585008827 oligomer interface; other site 1052585008828 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1052585008829 dimer interface [polypeptide binding]; other site 1052585008830 N-terminal domain interface [polypeptide binding]; other site 1052585008831 sulfate 1 binding site; other site 1052585008832 alpha-1,4-glucan:alpha-1,4-glucan 6-glycosyltransferase; Region: branching_enzym; TIGR01515 1052585008833 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1052585008834 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1052585008835 active site 1052585008836 catalytic site [active] 1052585008837 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 1052585008838 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 1052585008839 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1052585008840 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585008841 Coenzyme A binding pocket [chemical binding]; other site 1052585008842 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1052585008843 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1052585008844 DinB superfamily; Region: DinB_2; pfam12867 1052585008845 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 1052585008846 MOSC domain; Region: MOSC; pfam03473 1052585008847 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1052585008848 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1052585008849 active site 1052585008850 NAD binding site [chemical binding]; other site 1052585008851 metal binding site [ion binding]; metal-binding site 1052585008852 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 1052585008853 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1052585008854 tetramerization interface [polypeptide binding]; other site 1052585008855 NAD(P) binding site [chemical binding]; other site 1052585008856 catalytic residues [active] 1052585008857 Predicted transcriptional regulators [Transcription]; Region: COG1510 1052585008858 Helix-turn-helix domains; Region: HTH; cl00088 1052585008859 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1052585008860 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585008861 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1052585008862 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1052585008863 Cation transport protein; Region: TrkH; cl10514 1052585008864 yiaA/B two helix domain; Region: YiaAB; cl01759 1052585008865 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1052585008866 SH3-like domain; Region: SH3_8; pfam13457 1052585008867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585008868 putative substrate translocation pore; other site 1052585008869 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1052585008870 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1052585008871 DNA binding site [nucleotide binding] 1052585008872 active site 1052585008873 Int/Topo IB signature motif; other site 1052585008874 Bacitracin resistance protein BacA; Region: BacA; cl00858 1052585008875 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1052585008876 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1052585008877 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052585008878 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585008879 L-rhamnose isomerase; Provisional; Region: PRK01076 1052585008880 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 1052585008881 Domain of unknown function (DUF718); Region: DUF718; cl01281 1052585008882 L-rhamnulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1052585008883 N- and C-terminal domain interface [polypeptide binding]; other site 1052585008884 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 1052585008885 active site 1052585008886 catalytic site [active] 1052585008887 metal binding site [ion binding]; metal-binding site 1052585008888 ATP binding site [chemical binding]; other site 1052585008889 carbohydrate binding site [chemical binding]; other site 1052585008890 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1052585008891 Helix-turn-helix domains; Region: HTH; cl00088 1052585008892 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1052585008893 short chain dehydrogenase; Validated; Region: PRK08324 1052585008894 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1052585008895 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 1052585008896 putative NAD(P) binding site [chemical binding]; other site 1052585008897 active site 1052585008898 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1052585008899 Cache domain; Region: Cache_1; pfam02743 1052585008900 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052585008901 dimerization interface [polypeptide binding]; other site 1052585008902 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052585008903 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052585008904 dimer interface [polypeptide binding]; other site 1052585008905 putative CheW interface [polypeptide binding]; other site 1052585008906 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052585008907 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1052585008908 Cache domain; Region: Cache_1; pfam02743 1052585008909 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052585008910 dimerization interface [polypeptide binding]; other site 1052585008911 proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785 1052585008912 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052585008913 dimer interface [polypeptide binding]; other site 1052585008914 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1052585008915 putative CheW interface [polypeptide binding]; other site 1052585008916 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1052585008917 Cache domain; Region: Cache_1; pfam02743 1052585008918 sensor protein RstB; Provisional; Region: PRK10604 1052585008919 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052585008920 dimerization interface [polypeptide binding]; other site 1052585008921 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052585008922 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052585008923 dimer interface [polypeptide binding]; other site 1052585008924 putative CheW interface [polypeptide binding]; other site 1052585008925 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052585008926 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1052585008927 Cache domain; Region: Cache_1; pfam02743 1052585008928 sensor protein RstB; Provisional; Region: PRK10604 1052585008929 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052585008930 dimerization interface [polypeptide binding]; other site 1052585008931 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052585008932 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052585008933 dimer interface [polypeptide binding]; other site 1052585008934 putative CheW interface [polypeptide binding]; other site 1052585008935 transglutaminase; Provisional; Region: tgl; PRK03187 1052585008936 Nitronate monooxygenase; Region: NMO; pfam03060 1052585008937 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1052585008938 FMN binding site [chemical binding]; other site 1052585008939 substrate binding site [chemical binding]; other site 1052585008940 putative catalytic residue [active] 1052585008941 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 1052585008942 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1052585008943 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1052585008944 Ca binding site [ion binding]; other site 1052585008945 active site 1052585008946 catalytic site [active] 1052585008947 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1052585008948 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1052585008949 Domain of unknown function DUF21; Region: DUF21; pfam01595 1052585008950 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1052585008951 Transporter associated domain; Region: CorC_HlyC; cl08393 1052585008952 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 1052585008953 Membrane-integrating protein Mistic; Region: Mistic; pfam11458 1052585008954 Ion channel; Region: Ion_trans_2; cl11596 1052585008955 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1052585008956 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585008957 YugN-like family; Region: YugN; pfam08868 1052585008958 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1052585008959 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1052585008960 active site 1052585008961 dimer interface [polypeptide binding]; other site 1052585008962 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1052585008963 dimer interface [polypeptide binding]; other site 1052585008964 active site 1052585008965 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1052585008966 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1052585008967 dimer interface [polypeptide binding]; other site 1052585008968 active site 1052585008969 metal binding site [ion binding]; metal-binding site 1052585008970 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1052585008971 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1052585008972 dimer interface [polypeptide binding]; other site 1052585008973 active site 1052585008974 metal binding site [ion binding]; metal-binding site 1052585008975 Domain of unknown function (DUF378); Region: DUF378; cl00943 1052585008976 general stress protein 13; Validated; Region: PRK08059 1052585008977 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 1052585008978 RNA binding site [nucleotide binding]; other site 1052585008979 hypothetical protein; Validated; Region: PRK07682 1052585008980 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052585008981 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585008982 homodimer interface [polypeptide binding]; other site 1052585008983 catalytic residue [active] 1052585008984 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1052585008985 Helix-turn-helix domains; Region: HTH; cl00088 1052585008986 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052585008987 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052585008988 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 1052585008989 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1052585008990 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052585008991 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585008992 homodimer interface [polypeptide binding]; other site 1052585008993 catalytic residue [active] 1052585008994 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052585008995 dimer interface [polypeptide binding]; other site 1052585008996 phosphorylation site [posttranslational modification] 1052585008997 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585008998 ATP binding site [chemical binding]; other site 1052585008999 Mg2+ binding site [ion binding]; other site 1052585009000 G-X-G motif; other site 1052585009001 Kinase associated protein B; Region: KapB; pfam08810 1052585009002 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1052585009003 active site 1052585009004 substrate binding site [chemical binding]; other site 1052585009005 catalytic site [active] 1052585009006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585009007 drug efflux system protein MdtG; Provisional; Region: PRK09874 1052585009008 putative substrate translocation pore; other site 1052585009009 Transglycosylase; Region: Transgly; cl07896 1052585009010 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1052585009011 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052585009012 Protein of unknown function, DUF393; Region: DUF393; cl01136 1052585009013 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1052585009014 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1052585009015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585009016 ATP binding site [chemical binding]; other site 1052585009017 Mg2+ binding site [ion binding]; other site 1052585009018 G-X-G motif; other site 1052585009019 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1052585009020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585009021 active site 1052585009022 phosphorylation site [posttranslational modification] 1052585009023 intermolecular recognition site; other site 1052585009024 dimerization interface [polypeptide binding]; other site 1052585009025 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1052585009026 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1052585009027 ligand binding site [chemical binding]; other site 1052585009028 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1052585009029 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585009030 Walker A/P-loop; other site 1052585009031 ATP binding site [chemical binding]; other site 1052585009032 Q-loop/lid; other site 1052585009033 ABC transporter signature motif; other site 1052585009034 Walker B; other site 1052585009035 D-loop; other site 1052585009036 H-loop/switch region; other site 1052585009037 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 1052585009038 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1052585009039 TM-ABC transporter signature motif; other site 1052585009040 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1052585009041 TM-ABC transporter signature motif; other site 1052585009042 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 1052585009043 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 1052585009044 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 1052585009045 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1052585009046 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1052585009047 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1052585009048 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 1052585009049 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 1052585009050 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 1052585009051 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 1052585009052 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 1052585009053 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1052585009054 CoenzymeA binding site [chemical binding]; other site 1052585009055 subunit interaction site [polypeptide binding]; other site 1052585009056 PHB binding site; other site 1052585009057 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052585009058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585009059 active site 1052585009060 phosphorylation site [posttranslational modification] 1052585009061 intermolecular recognition site; other site 1052585009062 dimerization interface [polypeptide binding]; other site 1052585009063 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052585009064 DNA binding residues [nucleotide binding] 1052585009065 dimerization interface [polypeptide binding]; other site 1052585009066 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1052585009067 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1052585009068 Histidine kinase; Region: HisKA_3; pfam07730 1052585009069 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585009070 ATP binding site [chemical binding]; other site 1052585009071 Mg2+ binding site [ion binding]; other site 1052585009072 G-X-G motif; other site 1052585009073 Bacillus competence pheromone ComX; Region: ComX; pfam05952 1052585009074 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1052585009075 substrate binding pocket [chemical binding]; other site 1052585009076 substrate-Mg2+ binding site; other site 1052585009077 aspartate-rich region 1; other site 1052585009078 DegQ (SacQ) family; Region: DegQ; pfam08181 1052585009079 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1052585009080 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1052585009081 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1052585009082 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1052585009083 active site 1052585009084 Isochorismatase family; Region: Isochorismatase; pfam00857 1052585009085 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1052585009086 catalytic triad [active] 1052585009087 conserved cis-peptide bond; other site 1052585009088 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 1052585009089 YueH-like protein; Region: YueH; pfam14166 1052585009090 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1052585009091 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1052585009092 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 1052585009093 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 1052585009094 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 1052585009095 short chain dehydrogenase; Provisional; Region: PRK06924 1052585009096 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 1052585009097 NADP binding site [chemical binding]; other site 1052585009098 homodimer interface [polypeptide binding]; other site 1052585009099 active site 1052585009100 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 1052585009101 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 1052585009102 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1052585009103 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 1052585009104 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 1052585009105 Predicted membrane protein [Function unknown]; Region: COG1511 1052585009106 exosortase F-associated protein; Region: flavo_near_exo; TIGR04127 1052585009107 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1052585009108 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585009109 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585009110 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585009111 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 1052585009112 Ubiquitin-like proteins; Region: UBQ; cl00155 1052585009113 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1052585009114 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1052585009115 CodY GAF-like domain; Region: CodY; pfam06018 1052585009116 Helix-turn-helix domains; Region: HTH; cl00088 1052585009117 alanine dehydrogenase; Region: alaDH; TIGR00518 1052585009118 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 1052585009119 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585009120 Uncharacterized conserved protein [Function unknown]; Region: COG5634 1052585009121 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 1052585009122 MbtH-like protein; Region: MbtH; cl01279 1052585009123 peptide synthase; Provisional; Region: PRK12316 1052585009124 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585009125 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585009126 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585009127 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1052585009128 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052585009129 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585009130 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585009131 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585009132 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1052585009133 hydrophobic substrate binding pocket; other site 1052585009134 Isochorismatase family; Region: Isochorismatase; pfam00857 1052585009135 active site 1052585009136 conserved cis-peptide bond; other site 1052585009137 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585009138 2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275 1052585009139 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585009140 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585009141 isochorismate synthase DhbC; Validated; Region: PRK06923 1052585009142 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1052585009143 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1052585009144 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 1052585009145 putative NAD(P) binding site [chemical binding]; other site 1052585009146 active site 1052585009147 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052585009148 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1052585009149 Moco binding site; other site 1052585009150 metal coordination site [ion binding]; other site 1052585009151 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 1052585009152 Predicted permease [General function prediction only]; Region: COG2056 1052585009153 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 1052585009154 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 1052585009155 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1052585009156 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1052585009157 interface (dimer of trimers) [polypeptide binding]; other site 1052585009158 Substrate-binding/catalytic site; other site 1052585009159 Zn-binding sites [ion binding]; other site 1052585009160 Divergent PAP2 family; Region: DUF212; cl00855 1052585009161 3D domain; Region: 3D; cl01439 1052585009162 Putative membrane protein; Region: YuiB; pfam14068 1052585009163 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107 1052585009164 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1052585009165 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052585009166 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1052585009167 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052585009168 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1052585009169 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 1052585009170 active site 1052585009171 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1052585009172 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1052585009173 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585009174 Coenzyme A binding pocket [chemical binding]; other site 1052585009175 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1052585009176 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1052585009177 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 1052585009178 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 1052585009179 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1052585009180 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1052585009181 Nucleoside recognition; Region: Gate; cl00486 1052585009182 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1052585009183 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1052585009184 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1052585009185 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052585009186 Protein of unknown function (DUF1462); Region: DUF1462; cl11552 1052585009187 NifU-like domain; Region: NifU; cl00484 1052585009188 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1052585009189 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1052585009190 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1052585009191 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052585009192 homoserine kinase; Region: thrB; TIGR00191 1052585009193 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1052585009194 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1052585009195 threonine synthase; Reviewed; Region: PRK06721 1052585009196 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1052585009197 homodimer interface [polypeptide binding]; other site 1052585009198 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585009199 catalytic residue [active] 1052585009200 homoserine dehydrogenase; Provisional; Region: PRK06349 1052585009201 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585009202 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1052585009203 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1052585009204 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052585009205 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1052585009206 tetramer interfaces [polypeptide binding]; other site 1052585009207 binuclear metal-binding site [ion binding]; other site 1052585009208 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1052585009209 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585009210 active site 1052585009211 motif I; other site 1052585009212 motif II; other site 1052585009213 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585009214 Protein of unknown function DUF86; Region: DUF86; cl01031 1052585009215 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 1052585009216 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1052585009217 lipoyl synthase; Provisional; Region: PRK05481 1052585009218 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052585009219 FeS/SAM binding site; other site 1052585009220 Peptidase family M23; Region: Peptidase_M23; pfam01551 1052585009221 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 1052585009222 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 1052585009223 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1052585009224 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1052585009225 active site 1052585009226 metal binding site [ion binding]; metal-binding site 1052585009227 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1052585009228 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 1052585009229 Protein of unknown function DUF72; Region: DUF72; cl00777 1052585009230 allantoinase; Provisional; Region: PRK06189 1052585009231 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1052585009232 active site 1052585009233 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1052585009234 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1052585009235 Helix-turn-helix domains; Region: HTH; cl00088 1052585009236 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1052585009237 xanthine permease; Region: pbuX; TIGR03173 1052585009238 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1052585009239 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1052585009240 xanthine permease; Region: pbuX; TIGR03173 1052585009241 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 1052585009242 Uricase (urate oxidase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3648 1052585009243 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1052585009244 active site 1052585009245 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1052585009246 active site 1052585009247 homotetramer interface [polypeptide binding]; other site 1052585009248 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1052585009249 catalytic residues [active] 1052585009250 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1052585009251 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 1052585009252 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1052585009253 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 1052585009254 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1052585009255 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 1052585009256 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 1052585009257 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1052585009258 xanthine dehydrogenase C subunit; Region: pucC; TIGR03199 1052585009259 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1052585009260 Ligand binding site; other site 1052585009261 metal-binding site 1052585009262 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1052585009263 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1052585009264 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1052585009265 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1052585009266 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052585009267 catalytic residue [active] 1052585009268 allantoate amidohydrolase; Reviewed; Region: PRK09290 1052585009269 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1052585009270 active site 1052585009271 metal binding site [ion binding]; metal-binding site 1052585009272 dimer interface [polypeptide binding]; other site 1052585009273 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1052585009274 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1052585009275 Endonuclease I; Region: Endonuclease_1; cl01003 1052585009276 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1052585009277 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 1052585009278 Walker A/P-loop; other site 1052585009279 ATP binding site [chemical binding]; other site 1052585009280 Q-loop/lid; other site 1052585009281 ABC transporter signature motif; other site 1052585009282 Walker B; other site 1052585009283 D-loop; other site 1052585009284 H-loop/switch region; other site 1052585009285 TOBE domain; Region: TOBE_2; cl01440 1052585009286 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 1052585009287 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585009288 DNA-binding site [nucleotide binding]; DNA binding site 1052585009289 UTRA domain; Region: UTRA; cl01230 1052585009290 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1052585009291 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 1052585009292 substrate binding site [chemical binding]; other site 1052585009293 ATP binding site [chemical binding]; other site 1052585009294 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052585009295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585009296 dimer interface [polypeptide binding]; other site 1052585009297 conserved gate region; other site 1052585009298 putative PBP binding loops; other site 1052585009299 ABC-ATPase subunit interface; other site 1052585009300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585009301 dimer interface [polypeptide binding]; other site 1052585009302 conserved gate region; other site 1052585009303 putative PBP binding loops; other site 1052585009304 ABC-ATPase subunit interface; other site 1052585009305 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052585009306 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1052585009307 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1052585009308 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1052585009309 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1052585009310 putative active site [active] 1052585009311 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1052585009312 dimer interface [polypeptide binding]; other site 1052585009313 active site 1052585009314 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1052585009315 active site 1052585009316 catalytic site [active] 1052585009317 putative DNA binding site [nucleotide binding]; other site 1052585009318 GIY-YIG motif/motif A; other site 1052585009319 metal binding site [ion binding]; metal-binding site 1052585009320 FAD dependent oxidoreductase; Region: DAO; pfam01266 1052585009321 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585009322 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1052585009323 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052585009324 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1052585009325 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 1052585009326 FeS assembly protein SufB; Region: sufB; TIGR01980 1052585009327 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1052585009328 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1052585009329 trimerization site [polypeptide binding]; other site 1052585009330 active site 1052585009331 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1052585009332 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1052585009333 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052585009334 catalytic residue [active] 1052585009335 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1052585009336 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 1052585009337 FeS assembly ATPase SufC; Region: sufC; TIGR01978 1052585009338 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 1052585009339 Walker A/P-loop; other site 1052585009340 ATP binding site [chemical binding]; other site 1052585009341 Q-loop/lid; other site 1052585009342 ABC transporter signature motif; other site 1052585009343 Walker B; other site 1052585009344 D-loop; other site 1052585009345 H-loop/switch region; other site 1052585009346 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1052585009347 NMT1-like family; Region: NMT1_2; cl15260 1052585009348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585009349 dimer interface [polypeptide binding]; other site 1052585009350 conserved gate region; other site 1052585009351 ABC-ATPase subunit interface; other site 1052585009352 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1052585009353 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 1052585009354 Walker A/P-loop; other site 1052585009355 ATP binding site [chemical binding]; other site 1052585009356 Q-loop/lid; other site 1052585009357 ABC transporter signature motif; other site 1052585009358 Walker B; other site 1052585009359 D-loop; other site 1052585009360 H-loop/switch region; other site 1052585009361 NIL domain; Region: NIL; cl09633 1052585009362 SCP-2 sterol transfer family; Region: SCP2; cl01225 1052585009363 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1052585009364 catalytic residues [active] 1052585009365 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1052585009366 putative active site [active] 1052585009367 putative metal binding site [ion binding]; other site 1052585009368 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 1052585009369 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1052585009370 lipoyl attachment site [posttranslational modification]; other site 1052585009371 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1052585009372 ArsC family; Region: ArsC; pfam03960 1052585009373 putative ArsC-like catalytic residues; other site 1052585009374 putative TRX-like catalytic residues [active] 1052585009375 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1052585009376 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1052585009377 active site 1052585009378 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 1052585009379 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1052585009380 dimer interface [polypeptide binding]; other site 1052585009381 active site 1052585009382 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1052585009383 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585009384 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1052585009385 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1052585009386 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1052585009387 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1052585009388 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1052585009389 substrate binding site [chemical binding]; other site 1052585009390 oxyanion hole (OAH) forming residues; other site 1052585009391 trimer interface [polypeptide binding]; other site 1052585009392 Proline dehydrogenase; Region: Pro_dh; cl03282 1052585009393 Coat F domain; Region: Coat_F; cl15836 1052585009394 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585009395 Helix-turn-helix domains; Region: HTH; cl00088 1052585009396 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1052585009397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585009398 putative substrate translocation pore; other site 1052585009399 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1052585009400 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1052585009401 classical (c) SDRs; Region: SDR_c; cd05233 1052585009402 NAD(P) binding site [chemical binding]; other site 1052585009403 active site 1052585009404 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052585009405 Helix-turn-helix domains; Region: HTH; cl00088 1052585009406 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1052585009407 putative dimerization interface [polypeptide binding]; other site 1052585009408 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 1052585009409 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1052585009410 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1052585009411 Walker A/P-loop; other site 1052585009412 ATP binding site [chemical binding]; other site 1052585009413 Q-loop/lid; other site 1052585009414 ABC transporter signature motif; other site 1052585009415 Walker B; other site 1052585009416 D-loop; other site 1052585009417 H-loop/switch region; other site 1052585009418 YusW-like protein; Region: YusW; pfam14039 1052585009419 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1052585009420 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 1052585009421 active site 1052585009422 Zn binding site [ion binding]; other site 1052585009423 short chain dehydrogenase; Provisional; Region: PRK06914 1052585009424 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1052585009425 NADP binding site [chemical binding]; other site 1052585009426 active site 1052585009427 steroid binding site; other site 1052585009428 Ferritin-like domain; Region: Ferritin; pfam00210 1052585009429 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1052585009430 dimerization interface [polypeptide binding]; other site 1052585009431 DPS ferroxidase diiron center [ion binding]; other site 1052585009432 ion pore; other site 1052585009433 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1052585009434 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1052585009435 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1052585009436 protein binding site [polypeptide binding]; other site 1052585009437 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052585009438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585009439 active site 1052585009440 phosphorylation site [posttranslational modification] 1052585009441 intermolecular recognition site; other site 1052585009442 dimerization interface [polypeptide binding]; other site 1052585009443 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052585009444 DNA binding site [nucleotide binding] 1052585009445 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052585009446 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052585009447 dimerization interface [polypeptide binding]; other site 1052585009448 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052585009449 dimer interface [polypeptide binding]; other site 1052585009450 phosphorylation site [posttranslational modification] 1052585009451 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585009452 ATP binding site [chemical binding]; other site 1052585009453 Mg2+ binding site [ion binding]; other site 1052585009454 G-X-G motif; other site 1052585009455 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585009456 Helix-turn-helix domains; Region: HTH; cl00088 1052585009457 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1052585009458 Class II fumarases; Region: Fumarase_classII; cd01362 1052585009459 active site 1052585009460 tetramer interface [polypeptide binding]; other site 1052585009461 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 1052585009462 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1052585009463 Spore germination protein; Region: Spore_permease; cl15802 1052585009464 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 1052585009465 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052585009466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585009467 active site 1052585009468 phosphorylation site [posttranslational modification] 1052585009469 intermolecular recognition site; other site 1052585009470 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052585009471 DNA binding residues [nucleotide binding] 1052585009472 dimerization interface [polypeptide binding]; other site 1052585009473 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052585009474 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1052585009475 Histidine kinase; Region: HisKA_3; pfam07730 1052585009476 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585009477 ATP binding site [chemical binding]; other site 1052585009478 Mg2+ binding site [ion binding]; other site 1052585009479 G-X-G motif; other site 1052585009480 Predicted membrane protein [Function unknown]; Region: COG4758 1052585009481 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1052585009482 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1052585009483 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1052585009484 PspA/IM30 family; Region: PspA_IM30; pfam04012 1052585009485 H+ Antiporter protein; Region: 2A0121; TIGR00900 1052585009486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585009487 putative substrate translocation pore; other site 1052585009488 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 1052585009489 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1052585009490 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1052585009491 Walker A/P-loop; other site 1052585009492 ATP binding site [chemical binding]; other site 1052585009493 Q-loop/lid; other site 1052585009494 ABC transporter signature motif; other site 1052585009495 Walker B; other site 1052585009496 D-loop; other site 1052585009497 H-loop/switch region; other site 1052585009498 Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808 1052585009499 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052585009500 ABC-ATPase subunit interface; other site 1052585009501 dimer interface [polypeptide binding]; other site 1052585009502 putative PBP binding regions; other site 1052585009503 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1052585009504 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1052585009505 putative binding site residues; other site 1052585009506 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1052585009507 classical (c) SDRs; Region: SDR_c; cd05233 1052585009508 NAD(P) binding site [chemical binding]; other site 1052585009509 active site 1052585009510 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1052585009511 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052585009512 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052585009513 dimer interface [polypeptide binding]; other site 1052585009514 phosphorylation site [posttranslational modification] 1052585009515 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585009516 ATP binding site [chemical binding]; other site 1052585009517 Mg2+ binding site [ion binding]; other site 1052585009518 G-X-G motif; other site 1052585009519 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052585009520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585009521 active site 1052585009522 phosphorylation site [posttranslational modification] 1052585009523 intermolecular recognition site; other site 1052585009524 dimerization interface [polypeptide binding]; other site 1052585009525 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052585009526 DNA binding site [nucleotide binding] 1052585009527 hypothetical protein; Provisional; Region: PRK14082 1052585009528 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1052585009529 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052585009530 DNA binding residues [nucleotide binding] 1052585009531 YvrJ protein family; Region: YvrJ; pfam12841 1052585009532 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1052585009533 Cupin domain; Region: Cupin_2; cl09118 1052585009534 Cupin domain; Region: Cupin_2; cl09118 1052585009535 Regulatory protein YrvL; Region: YrvL; pfam14184 1052585009536 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1052585009537 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1052585009538 FtsX-like permease family; Region: FtsX; cl15850 1052585009539 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052585009540 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1052585009541 Walker A/P-loop; other site 1052585009542 ATP binding site [chemical binding]; other site 1052585009543 Q-loop/lid; other site 1052585009544 ABC transporter signature motif; other site 1052585009545 Walker B; other site 1052585009546 D-loop; other site 1052585009547 H-loop/switch region; other site 1052585009548 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 1052585009549 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1052585009550 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1052585009551 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1052585009552 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1052585009553 Walker A/P-loop; other site 1052585009554 ATP binding site [chemical binding]; other site 1052585009555 Q-loop/lid; other site 1052585009556 ABC transporter signature motif; other site 1052585009557 Walker B; other site 1052585009558 D-loop; other site 1052585009559 H-loop/switch region; other site 1052585009560 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052585009561 ABC-ATPase subunit interface; other site 1052585009562 dimer interface [polypeptide binding]; other site 1052585009563 putative PBP binding regions; other site 1052585009564 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052585009565 ABC-ATPase subunit interface; other site 1052585009566 dimer interface [polypeptide binding]; other site 1052585009567 putative PBP binding regions; other site 1052585009568 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1052585009569 putative ligand binding residues [chemical binding]; other site 1052585009570 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1052585009571 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1052585009572 Spore germination protein; Region: Spore_permease; cl15802 1052585009573 Small spore protein J (Spore_SspJ); Region: Spore_SspJ; cl09798 1052585009574 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 1052585009575 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1052585009576 Sulfatase; Region: Sulfatase; cl10460 1052585009577 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1052585009578 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1052585009579 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1052585009580 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1052585009581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585009582 dimer interface [polypeptide binding]; other site 1052585009583 conserved gate region; other site 1052585009584 putative PBP binding loops; other site 1052585009585 ABC-ATPase subunit interface; other site 1052585009586 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052585009587 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052585009588 active site 1052585009589 catalytic tetrad [active] 1052585009590 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1052585009591 Synaptonemal complex protein 1 (SCP-1); Region: SCP-1; pfam05483 1052585009592 sulfite reductase subunit beta; Provisional; Region: PRK13504 1052585009593 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1052585009594 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1052585009595 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 1052585009596 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1052585009597 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1052585009598 FAD binding pocket [chemical binding]; other site 1052585009599 FAD binding motif [chemical binding]; other site 1052585009600 catalytic residues [active] 1052585009601 NAD binding pocket [chemical binding]; other site 1052585009602 phosphate binding motif [ion binding]; other site 1052585009603 beta-alpha-beta structure motif; other site 1052585009604 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1052585009605 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585009606 Family description; Region: UvrD_C_2; cl15862 1052585009607 UPF0126 domain; Region: UPF0126; pfam03458 1052585009608 UPF0126 domain; Region: UPF0126; pfam03458 1052585009609 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 1052585009610 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1052585009611 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1052585009612 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1052585009613 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1052585009614 metal-binding site [ion binding] 1052585009615 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1052585009616 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1052585009617 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1052585009618 metal-binding site [ion binding] 1052585009619 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1052585009620 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1052585009621 metal-binding site [ion binding] 1052585009622 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1052585009623 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1052585009624 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1052585009625 metal-binding site [ion binding] 1052585009626 Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157 1052585009627 putative homotetramer interface [polypeptide binding]; other site 1052585009628 putative homodimer interface [polypeptide binding]; other site 1052585009629 allosteric switch controlling residues; other site 1052585009630 putative metal binding site [ion binding]; other site 1052585009631 putative homodimer-homodimer interface [polypeptide binding]; other site 1052585009632 putative oxidoreductase; Provisional; Region: PRK11579 1052585009633 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585009634 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1052585009635 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1052585009636 Predicted membrane protein [Function unknown]; Region: COG1289 1052585009637 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1052585009638 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 1052585009639 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1052585009640 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585009641 DNA-binding site [nucleotide binding]; DNA binding site 1052585009642 FCD domain; Region: FCD; cl11656 1052585009643 EamA-like transporter family; Region: EamA; cl01037 1052585009644 EamA-like transporter family; Region: EamA; cl01037 1052585009645 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1052585009646 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585009647 Helix-turn-helix domains; Region: HTH; cl00088 1052585009648 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1052585009649 classical (c) SDRs; Region: SDR_c; cd05233 1052585009650 NAD(P) binding site [chemical binding]; other site 1052585009651 active site 1052585009652 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1052585009653 SmpB-tmRNA interface; other site 1052585009654 ribonuclease R; Region: RNase_R; TIGR02063 1052585009655 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1052585009656 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1052585009657 RNB domain; Region: RNB; pfam00773 1052585009658 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 1052585009659 RNA binding site [nucleotide binding]; other site 1052585009660 Esterase/lipase [General function prediction only]; Region: COG1647 1052585009661 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052585009662 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 1052585009663 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052585009664 salt bridge; other site 1052585009665 non-specific DNA binding site [nucleotide binding]; other site 1052585009666 sequence-specific DNA binding site [nucleotide binding]; other site 1052585009667 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052585009668 non-specific DNA binding site [nucleotide binding]; other site 1052585009669 salt bridge; other site 1052585009670 sequence-specific DNA binding site [nucleotide binding]; other site 1052585009671 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052585009672 non-specific DNA binding site [nucleotide binding]; other site 1052585009673 salt bridge; other site 1052585009674 sequence-specific DNA binding site [nucleotide binding]; other site 1052585009675 Helix-turn-helix domains; Region: HTH; cl00088 1052585009676 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1052585009677 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052585009678 dimerization interface [polypeptide binding]; other site 1052585009679 proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785 1052585009680 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052585009681 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052585009682 dimer interface [polypeptide binding]; other site 1052585009683 putative CheW interface [polypeptide binding]; other site 1052585009684 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052585009685 dimer interface [polypeptide binding]; other site 1052585009686 phosphorylation site [posttranslational modification] 1052585009687 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585009688 ATP binding site [chemical binding]; other site 1052585009689 Mg2+ binding site [ion binding]; other site 1052585009690 G-X-G motif; other site 1052585009691 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052585009692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585009693 active site 1052585009694 phosphorylation site [posttranslational modification] 1052585009695 intermolecular recognition site; other site 1052585009696 dimerization interface [polypeptide binding]; other site 1052585009697 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052585009698 DNA binding site [nucleotide binding] 1052585009699 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1052585009700 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1052585009701 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1052585009702 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 1052585009703 Walker A/P-loop; other site 1052585009704 ATP binding site [chemical binding]; other site 1052585009705 Q-loop/lid; other site 1052585009706 ABC transporter signature motif; other site 1052585009707 Walker B; other site 1052585009708 D-loop; other site 1052585009709 H-loop/switch region; other site 1052585009710 LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793 1052585009711 active site 1052585009712 zinc binding site [ion binding]; other site 1052585009713 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052585009714 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 1052585009715 Walker A/P-loop; other site 1052585009716 ATP binding site [chemical binding]; other site 1052585009717 Q-loop/lid; other site 1052585009718 ABC transporter signature motif; other site 1052585009719 Walker B; other site 1052585009720 D-loop; other site 1052585009721 H-loop/switch region; other site 1052585009722 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 1052585009723 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 1052585009724 SpaB C-terminal domain; Region: SpaB_C; cl14828 1052585009725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585009726 dimer interface [polypeptide binding]; other site 1052585009727 conserved gate region; other site 1052585009728 putative PBP binding loops; other site 1052585009729 ABC-ATPase subunit interface; other site 1052585009730 NMT1-like family; Region: NMT1_2; cl15260 1052585009731 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1052585009732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585009733 dimer interface [polypeptide binding]; other site 1052585009734 conserved gate region; other site 1052585009735 putative PBP binding loops; other site 1052585009736 ABC-ATPase subunit interface; other site 1052585009737 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 1052585009738 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1052585009739 Walker A/P-loop; other site 1052585009740 ATP binding site [chemical binding]; other site 1052585009741 Q-loop/lid; other site 1052585009742 ABC transporter signature motif; other site 1052585009743 Walker B; other site 1052585009744 D-loop; other site 1052585009745 H-loop/switch region; other site 1052585009746 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1052585009747 Predicted transcriptional regulators [Transcription]; Region: COG1510 1052585009748 Helix-turn-helix domains; Region: HTH; cl00088 1052585009749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585009750 dimer interface [polypeptide binding]; other site 1052585009751 conserved gate region; other site 1052585009752 putative PBP binding loops; other site 1052585009753 ABC-ATPase subunit interface; other site 1052585009754 NMT1-like family; Region: NMT1_2; cl15260 1052585009755 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1052585009756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585009757 dimer interface [polypeptide binding]; other site 1052585009758 conserved gate region; other site 1052585009759 putative PBP binding loops; other site 1052585009760 ABC-ATPase subunit interface; other site 1052585009761 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 1052585009762 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 1052585009763 Walker A/P-loop; other site 1052585009764 ATP binding site [chemical binding]; other site 1052585009765 Q-loop/lid; other site 1052585009766 ABC transporter signature motif; other site 1052585009767 Walker B; other site 1052585009768 D-loop; other site 1052585009769 H-loop/switch region; other site 1052585009770 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1052585009771 Predicted transcriptional regulators [Transcription]; Region: COG1510 1052585009772 Helix-turn-helix domains; Region: HTH; cl00088 1052585009773 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 1052585009774 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1052585009775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1052585009776 Predicted membrane protein [Function unknown]; Region: COG4640 1052585009777 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1052585009778 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585009779 Coenzyme A binding pocket [chemical binding]; other site 1052585009780 enolase; Provisional; Region: eno; PRK00077 1052585009781 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1052585009782 dimer interface [polypeptide binding]; other site 1052585009783 metal binding site [ion binding]; metal-binding site 1052585009784 substrate binding pocket [chemical binding]; other site 1052585009785 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1052585009786 Sulfatase; Region: Sulfatase; cl10460 1052585009787 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1052585009788 substrate binding site [chemical binding]; other site 1052585009789 dimer interface [polypeptide binding]; other site 1052585009790 catalytic triad [active] 1052585009791 Phosphoglycerate kinase; Region: PGK; pfam00162 1052585009792 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1052585009793 substrate binding site [chemical binding]; other site 1052585009794 hinge regions; other site 1052585009795 ADP binding site [chemical binding]; other site 1052585009796 catalytic site [active] 1052585009797 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585009798 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1052585009799 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 1052585009800 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1052585009801 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1052585009802 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1052585009803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585009804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585009805 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1052585009806 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1052585009807 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1052585009808 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052585009809 Helix-turn-helix domains; Region: HTH; cl00088 1052585009810 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052585009811 dimerization interface [polypeptide binding]; other site 1052585009812 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1052585009813 EamA-like transporter family; Region: EamA; cl01037 1052585009814 EamA-like transporter family; Region: EamA; cl01037 1052585009815 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1052585009816 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1052585009817 active site 1052585009818 Helix-turn-helix domains; Region: HTH; cl00088 1052585009819 putative transposase OrfB; Reviewed; Region: PHA02517 1052585009820 HTH-like domain; Region: HTH_21; pfam13276 1052585009821 Integrase core domain; Region: rve; cl01316 1052585009822 Integrase core domain; Region: rve_3; cl15866 1052585009823 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1052585009824 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 1052585009825 iron-sulfur cluster-binding protein; Region: TIGR00273 1052585009826 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 1052585009827 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1052585009828 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1052585009829 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 1052585009830 Cysteine-rich domain; Region: CCG; pfam02754 1052585009831 Cysteine-rich domain; Region: CCG; pfam02754 1052585009832 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 1052585009833 Helix-turn-helix domains; Region: HTH; cl00088 1052585009834 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052585009835 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585009836 active site 1052585009837 phosphorylation site [posttranslational modification] 1052585009838 intermolecular recognition site; other site 1052585009839 dimerization interface [polypeptide binding]; other site 1052585009840 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052585009841 DNA binding residues [nucleotide binding] 1052585009842 dimerization interface [polypeptide binding]; other site 1052585009843 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052585009844 Histidine kinase; Region: HisKA_3; pfam07730 1052585009845 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1052585009846 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1052585009847 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052585009848 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1052585009849 Walker A/P-loop; other site 1052585009850 ATP binding site [chemical binding]; other site 1052585009851 Q-loop/lid; other site 1052585009852 ABC transporter signature motif; other site 1052585009853 Walker B; other site 1052585009854 D-loop; other site 1052585009855 H-loop/switch region; other site 1052585009856 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052585009857 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052585009858 PAS domain; Region: PAS_9; pfam13426 1052585009859 putative active site [active] 1052585009860 heme pocket [chemical binding]; other site 1052585009861 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 1052585009862 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1052585009863 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 1052585009864 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1052585009865 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 1052585009866 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1052585009867 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1052585009868 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 1052585009869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585009870 dimer interface [polypeptide binding]; other site 1052585009871 conserved gate region; other site 1052585009872 putative PBP binding loops; other site 1052585009873 ABC-ATPase subunit interface; other site 1052585009874 TM2 domain; Region: TM2; cl00984 1052585009875 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052585009876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585009877 dimer interface [polypeptide binding]; other site 1052585009878 conserved gate region; other site 1052585009879 ABC-ATPase subunit interface; other site 1052585009880 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1052585009881 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1052585009882 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052585009883 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052585009884 DNA binding site [nucleotide binding] 1052585009885 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1052585009886 putative dimerization interface [polypeptide binding]; other site 1052585009887 putative ligand binding site [chemical binding]; other site 1052585009888 glycolate transporter; Provisional; Region: PRK09695 1052585009889 L-lactate permease; Region: Lactate_perm; cl00701 1052585009890 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 1052585009891 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1052585009892 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1052585009893 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1052585009894 YvfG protein; Region: YvfG; pfam09628 1052585009895 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1052585009896 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1052585009897 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1052585009898 inhibitor-cofactor binding pocket; inhibition site 1052585009899 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585009900 catalytic residue [active] 1052585009901 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1052585009902 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1052585009903 putative trimer interface [polypeptide binding]; other site 1052585009904 putative CoA binding site [chemical binding]; other site 1052585009905 Bacterial sugar transferase; Region: Bac_transf; cl00939 1052585009906 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1052585009907 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052585009908 active site 1052585009909 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1052585009910 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052585009911 active site 1052585009912 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052585009913 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 1052585009914 putative ADP-binding pocket [chemical binding]; other site 1052585009915 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1052585009916 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1052585009917 active site 1052585009918 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1052585009919 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052585009920 putative ADP-binding pocket [chemical binding]; other site 1052585009921 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1052585009922 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585009923 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1052585009924 NAD(P) binding site [chemical binding]; other site 1052585009925 homodimer interface [polypeptide binding]; other site 1052585009926 substrate binding site [chemical binding]; other site 1052585009927 active site 1052585009928 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1052585009929 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585009930 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1052585009931 Chain length determinant protein; Region: Wzz; cl15801 1052585009932 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052585009933 non-specific DNA binding site [nucleotide binding]; other site 1052585009934 salt bridge; other site 1052585009935 sequence-specific DNA binding site [nucleotide binding]; other site 1052585009936 Anti-repressor SinI; Region: SinI; pfam08671 1052585009937 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1052585009938 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1052585009939 substrate binding pocket [chemical binding]; other site 1052585009940 catalytic triad [active] 1052585009941 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 1052585009942 Protein of unknown function (DUF3237); Region: DUF3237; cl07905 1052585009943 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1052585009944 aspartate racemase; Region: asp_race; TIGR00035 1052585009945 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052585009946 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1052585009947 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 1052585009948 active site 1052585009949 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1052585009950 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1052585009951 substrate binding [chemical binding]; other site 1052585009952 active site 1052585009953 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1052585009954 amino acid transporter; Region: 2A0306; TIGR00909 1052585009955 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585009956 Helix-turn-helix domains; Region: HTH; cl00088 1052585009957 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1052585009958 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1052585009959 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 1052585009960 Clp protease; Region: CLP_protease; pfam00574 1052585009961 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1052585009962 oligomer interface [polypeptide binding]; other site 1052585009963 active site residues [active] 1052585009964 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1052585009965 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585009966 motif II; other site 1052585009967 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1052585009968 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1052585009969 Ca binding site [ion binding]; other site 1052585009970 active site 1052585009971 catalytic site [active] 1052585009972 maltose phosphorylase; Provisional; Region: PRK13807 1052585009973 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1052585009974 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1052585009975 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1052585009976 Predicted integral membrane protein [Function unknown]; Region: COG5521 1052585009977 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 1052585009978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585009979 dimer interface [polypeptide binding]; other site 1052585009980 conserved gate region; other site 1052585009981 ABC-ATPase subunit interface; other site 1052585009982 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052585009983 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585009984 dimer interface [polypeptide binding]; other site 1052585009985 conserved gate region; other site 1052585009986 putative PBP binding loops; other site 1052585009987 ABC-ATPase subunit interface; other site 1052585009988 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1052585009989 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1052585009990 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1052585009991 homodimer interface [polypeptide binding]; other site 1052585009992 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1052585009993 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1052585009994 active site 1052585009995 homodimer interface [polypeptide binding]; other site 1052585009996 catalytic site [active] 1052585009997 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052585009998 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052585009999 DNA binding site [nucleotide binding] 1052585010000 domain linker motif; other site 1052585010001 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1052585010002 ligand binding site [chemical binding]; other site 1052585010003 dimerization interface [polypeptide binding]; other site 1052585010004 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1052585010005 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 1052585010006 Sulfate transporter family; Region: Sulfate_transp; cl15842 1052585010007 putative transporter; Provisional; Region: PRK11660 1052585010008 Sulfate transporter family; Region: Sulfate_transp; cl15842 1052585010009 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1052585010010 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1052585010011 active site clefts [active] 1052585010012 zinc binding site [ion binding]; other site 1052585010013 dimer interface [polypeptide binding]; other site 1052585010014 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1052585010015 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585010016 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052585010017 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1052585010018 Walker A/P-loop; other site 1052585010019 ATP binding site [chemical binding]; other site 1052585010020 Q-loop/lid; other site 1052585010021 ABC transporter signature motif; other site 1052585010022 Walker B; other site 1052585010023 D-loop; other site 1052585010024 H-loop/switch region; other site 1052585010025 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052585010026 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1052585010027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585010028 ATP binding site [chemical binding]; other site 1052585010029 Mg2+ binding site [ion binding]; other site 1052585010030 G-X-G motif; other site 1052585010031 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052585010032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585010033 active site 1052585010034 phosphorylation site [posttranslational modification] 1052585010035 intermolecular recognition site; other site 1052585010036 dimerization interface [polypeptide binding]; other site 1052585010037 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052585010038 DNA binding site [nucleotide binding] 1052585010039 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1052585010040 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1052585010041 dimerization domain swap beta strand [polypeptide binding]; other site 1052585010042 regulatory protein interface [polypeptide binding]; other site 1052585010043 active site 1052585010044 regulatory phosphorylation site [posttranslational modification]; other site 1052585010045 conserved hypothetical protein; Region: MG103; TIGR00647 1052585010046 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1052585010047 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1052585010048 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1052585010049 phosphate binding site [ion binding]; other site 1052585010050 putative substrate binding pocket [chemical binding]; other site 1052585010051 dimer interface [polypeptide binding]; other site 1052585010052 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 1052585010053 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 1052585010054 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1052585010055 putative active site [active] 1052585010056 nucleotide binding site [chemical binding]; other site 1052585010057 nudix motif; other site 1052585010058 putative metal binding site [ion binding]; other site 1052585010059 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1052585010060 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585010061 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052585010062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1052585010063 NlpC/P60 family; Region: NLPC_P60; cl11438 1052585010064 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585010065 binding surface 1052585010066 TPR motif; other site 1052585010067 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1052585010068 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585010069 TPR motif; other site 1052585010070 binding surface 1052585010071 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052585010072 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1052585010073 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585010074 Walker A/P-loop; other site 1052585010075 ATP binding site [chemical binding]; other site 1052585010076 Q-loop/lid; other site 1052585010077 ABC transporter signature motif; other site 1052585010078 Walker B; other site 1052585010079 D-loop; other site 1052585010080 H-loop/switch region; other site 1052585010081 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1052585010082 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 1052585010083 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 1052585010084 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1052585010085 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1052585010086 substrate binding site [chemical binding]; other site 1052585010087 glutamase interaction surface [polypeptide binding]; other site 1052585010088 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1052585010089 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1052585010090 catalytic residues [active] 1052585010091 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1052585010092 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1052585010093 putative active site [active] 1052585010094 oxyanion strand; other site 1052585010095 catalytic triad [active] 1052585010096 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 1052585010097 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1052585010098 putative active site pocket [active] 1052585010099 4-fold oligomerization interface [polypeptide binding]; other site 1052585010100 metal binding residues [ion binding]; metal-binding site 1052585010101 3-fold/trimer interface [polypeptide binding]; other site 1052585010102 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1052585010103 histidinol dehydrogenase; Region: hisD; TIGR00069 1052585010104 NAD binding site [chemical binding]; other site 1052585010105 dimerization interface [polypeptide binding]; other site 1052585010106 product binding site; other site 1052585010107 substrate binding site [chemical binding]; other site 1052585010108 zinc binding site [ion binding]; other site 1052585010109 catalytic residues [active] 1052585010110 ATP phosphoribosyltransferase; Region: HisG; cl15266 1052585010111 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 1052585010112 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 1052585010113 dimer interface [polypeptide binding]; other site 1052585010114 motif 1; other site 1052585010115 active site 1052585010116 motif 2; other site 1052585010117 motif 3; other site 1052585010118 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 1052585010119 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 1052585010120 putative active site [active] 1052585010121 Pectate lyase; Region: Pectate_lyase; pfam03211 1052585010122 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1052585010123 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1052585010124 CoA binding site [chemical binding]; other site 1052585010125 active site 1052585010126 pyrophosphatase PpaX; Provisional; Region: PRK13288 1052585010127 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585010128 motif II; other site 1052585010129 Nucleoside recognition; Region: Gate; cl00486 1052585010130 Nucleoside recognition; Region: Gate; cl00486 1052585010131 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 1052585010132 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 1052585010133 DRTGG domain; Region: DRTGG; cl12147 1052585010134 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1052585010135 Hpr binding site; other site 1052585010136 active site 1052585010137 homohexamer subunit interaction site [polypeptide binding]; other site 1052585010138 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1052585010139 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1052585010140 active site 1052585010141 dimer interface [polypeptide binding]; other site 1052585010142 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1052585010143 active site 1052585010144 trimer interface [polypeptide binding]; other site 1052585010145 allosteric site; other site 1052585010146 active site lid [active] 1052585010147 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1052585010148 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1052585010149 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585010150 DNA-binding site [nucleotide binding]; DNA binding site 1052585010151 UTRA domain; Region: UTRA; cl01230 1052585010152 Lamin Tail Domain; Region: LTD; pfam00932 1052585010153 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 1052585010154 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1052585010155 putative active site [active] 1052585010156 putative metal binding site [ion binding]; other site 1052585010157 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585010158 Helix-turn-helix domains; Region: HTH; cl00088 1052585010159 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 1052585010160 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585010161 Helix-turn-helix domains; Region: HTH; cl00088 1052585010162 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585010163 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585010164 putative substrate translocation pore; other site 1052585010165 Membrane protein of unknown function; Region: DUF360; cl00850 1052585010166 PspC domain; Region: PspC; cl00864 1052585010167 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1052585010168 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1052585010169 flagellin; Provisional; Region: PRK12804 1052585010170 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1052585010171 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1052585010172 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1052585010173 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 1052585010174 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 1052585010175 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 1052585010176 excinuclease ABC subunit B; Provisional; Region: PRK05298 1052585010177 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052585010178 ATP binding site [chemical binding]; other site 1052585010179 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052585010180 nucleotide binding region [chemical binding]; other site 1052585010181 ATP-binding site [chemical binding]; other site 1052585010182 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1052585010183 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 1052585010184 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 1052585010185 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1052585010186 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 1052585010187 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585010188 Helix-turn-helix domains; Region: HTH; cl00088 1052585010189 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585010190 putative substrate translocation pore; other site 1052585010191 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1052585010192 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1052585010193 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1052585010194 C-terminal peptidase (prc); Region: prc; TIGR00225 1052585010195 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1052585010196 protein binding site [polypeptide binding]; other site 1052585010197 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1052585010198 Catalytic dyad [active] 1052585010199 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 1052585010200 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1052585010201 FtsX-like permease family; Region: FtsX; cl15850 1052585010202 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1052585010203 FtsE is a hydrophilic nucleotide-binding protein that binds FtsX to form a heterodimeric ATP-binding cassette (ABC)-type transporter that associates with the bacterial inner membrane. The FtsE/X transporter is thought to be involved in cell division and...; Region: ABC_FtsE_transporter; cd03292 1052585010204 Walker A/P-loop; other site 1052585010205 ATP binding site [chemical binding]; other site 1052585010206 Q-loop/lid; other site 1052585010207 ABC transporter signature motif; other site 1052585010208 Walker B; other site 1052585010209 D-loop; other site 1052585010210 H-loop/switch region; other site 1052585010211 Cytochrome c; Region: Cytochrom_C; cl11414 1052585010212 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1052585010213 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052585010214 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052585010215 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 1052585010216 putative transposase OrfB; Reviewed; Region: PHA02517 1052585010217 HTH-like domain; Region: HTH_21; pfam13276 1052585010218 Integrase core domain; Region: rve; cl01316 1052585010219 Integrase core domain; Region: rve_3; cl15866 1052585010220 Helix-turn-helix domains; Region: HTH; cl00088 1052585010221 peptide chain release factor 2; Provisional; Region: PRK06746 1052585010222 RF-1 domain; Region: RF-1; cl02875 1052585010223 RF-1 domain; Region: RF-1; cl02875 1052585010224 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1052585010225 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585010226 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 1052585010227 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585010228 SEC-C motif; Region: SEC-C; pfam02810 1052585010229 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 1052585010230 30S subunit binding site; other site 1052585010231 Flagellar protein FliT; Region: FliT; cl05125 1052585010232 Flagellar protein FliS; Region: FliS; cl00654 1052585010233 flagellar capping protein; Validated; Region: fliD; PRK07737 1052585010234 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1052585010235 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1052585010236 FlaG protein; Region: FlaG; cl00591 1052585010237 flagellin; Provisional; Region: PRK12804 1052585010238 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1052585010239 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1052585010240 Global regulator protein family; Region: CsrA; cl00670 1052585010241 FliW protein; Region: FliW; cl00740 1052585010242 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 1052585010243 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1052585010244 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1052585010245 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 1052585010246 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1052585010247 FlgN protein; Region: FlgN; cl09176 1052585010248 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 1052585010249 flagellar operon protein TIGR03826; Region: YvyF 1052585010250 comF family protein; Region: comF; TIGR00201 1052585010251 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052585010252 active site 1052585010253 Late competence development protein ComFB; Region: ComFB; pfam10719 1052585010254 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1052585010255 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052585010256 ATP binding site [chemical binding]; other site 1052585010257 putative Mg++ binding site [ion binding]; other site 1052585010258 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052585010259 nucleotide binding region [chemical binding]; other site 1052585010260 ATP-binding site [chemical binding]; other site 1052585010261 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 1052585010262 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052585010263 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585010264 active site 1052585010265 phosphorylation site [posttranslational modification] 1052585010266 intermolecular recognition site; other site 1052585010267 dimerization interface [polypeptide binding]; other site 1052585010268 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052585010269 DNA binding residues [nucleotide binding] 1052585010270 dimerization interface [polypeptide binding]; other site 1052585010271 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052585010272 Histidine kinase; Region: HisKA_3; pfam07730 1052585010273 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585010274 ATP binding site [chemical binding]; other site 1052585010275 Mg2+ binding site [ion binding]; other site 1052585010276 G-X-G motif; other site 1052585010277 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 1052585010278 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1052585010279 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1052585010280 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1052585010281 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585010282 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1052585010283 Walker A/P-loop; other site 1052585010284 ATP binding site [chemical binding]; other site 1052585010285 Q-loop/lid; other site 1052585010286 ABC transporter signature motif; other site 1052585010287 Walker B; other site 1052585010288 D-loop; other site 1052585010289 H-loop/switch region; other site 1052585010290 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1052585010291 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1052585010292 Mg++ binding site [ion binding]; other site 1052585010293 putative catalytic motif [active] 1052585010294 substrate binding site [chemical binding]; other site 1052585010295 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1052585010296 putative homodimer interface [polypeptide binding]; other site 1052585010297 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1052585010298 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052585010299 active site 1052585010300 Chain length determinant protein; Region: Wzz; cl15801 1052585010301 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 1052585010302 O-Antigen ligase; Region: Wzy_C; cl04850 1052585010303 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1052585010304 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585010305 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1052585010306 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585010307 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052585010308 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1052585010309 MatE; Region: MatE; cl10513 1052585010310 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1052585010311 Bacterial sugar transferase; Region: Bac_transf; cl00939 1052585010312 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052585010313 active site 1052585010314 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1052585010315 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 1052585010316 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1052585010317 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1052585010318 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1052585010319 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1052585010320 active site 1052585010321 metal binding site [ion binding]; metal-binding site 1052585010322 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1052585010323 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 1052585010324 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1052585010325 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1052585010326 Stage II sporulation protein; Region: SpoIID; pfam08486 1052585010327 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1052585010328 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1052585010329 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1052585010330 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1052585010331 active site 1052585010332 homodimer interface [polypeptide binding]; other site 1052585010333 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052585010334 active site 1052585010335 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 1052585010336 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1052585010337 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1052585010338 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1052585010339 active site 1052585010340 tetramer interface; other site 1052585010341 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1052585010342 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 1052585010343 Walker A/P-loop; other site 1052585010344 ATP binding site [chemical binding]; other site 1052585010345 Q-loop/lid; other site 1052585010346 ABC transporter signature motif; other site 1052585010347 Walker B; other site 1052585010348 D-loop; other site 1052585010349 H-loop/switch region; other site 1052585010350 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1052585010351 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052585010352 active site 1052585010353 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1052585010354 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1052585010355 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 1052585010356 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1052585010357 active site 1052585010358 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1052585010359 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1052585010360 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1052585010361 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1052585010362 substrate binding site; other site 1052585010363 dimer interface; other site 1052585010364 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 1052585010365 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1052585010366 putative NAD(P) binding site [chemical binding]; other site 1052585010367 putative catalytic Zn binding site [ion binding]; other site 1052585010368 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1052585010369 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1052585010370 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1052585010371 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 1052585010372 Bacterial SH3 domain; Region: SH3_3; cl02551 1052585010373 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1052585010374 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1052585010375 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 1052585010376 Spore germination protein; Region: Spore_permease; cl15802 1052585010377 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 1052585010378 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1052585010379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585010380 putative substrate translocation pore; other site 1052585010381 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1052585010382 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585010383 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1052585010384 active site 1052585010385 motif I; other site 1052585010386 motif II; other site 1052585010387 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1052585010388 NlpC/P60 family; Region: NLPC_P60; cl11438 1052585010389 NlpC/P60 family; Region: NLPC_P60; cl11438 1052585010390 NlpC/P60 family; Region: NLPC_P60; cl11438 1052585010391 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1052585010392 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1052585010393 putative active site [active] 1052585010394 putative metal binding site [ion binding]; other site 1052585010395 Capsule biosynthesis CapC; Region: Caps_synth_CapC; cl14855 1052585010396 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 1052585010397 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1052585010398 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052585010399 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052585010400 DNA binding site [nucleotide binding] 1052585010401 domain linker motif; other site 1052585010402 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1052585010403 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1052585010404 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1052585010405 substrate binding site [chemical binding]; other site 1052585010406 dimer interface [polypeptide binding]; other site 1052585010407 ATP binding site [chemical binding]; other site 1052585010408 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 1052585010409 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1052585010410 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 1052585010411 Walker A/P-loop; other site 1052585010412 ATP binding site [chemical binding]; other site 1052585010413 Q-loop/lid; other site 1052585010414 ABC transporter signature motif; other site 1052585010415 Walker B; other site 1052585010416 D-loop; other site 1052585010417 H-loop/switch region; other site 1052585010418 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 1052585010419 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1052585010420 TM-ABC transporter signature motif; other site 1052585010421 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1052585010422 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1052585010423 ligand binding site [chemical binding]; other site 1052585010424 dimerization interface [polypeptide binding]; other site 1052585010425 Bacterial SH3 domain; Region: SH3_3; cl02551 1052585010426 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 1052585010427 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 1052585010428 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1052585010429 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 1052585010430 acetolactate synthase; Reviewed; Region: PRK08617 1052585010431 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1052585010432 PYR/PP interface [polypeptide binding]; other site 1052585010433 dimer interface [polypeptide binding]; other site 1052585010434 TPP binding site [chemical binding]; other site 1052585010435 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1052585010436 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1052585010437 TPP-binding site [chemical binding]; other site 1052585010438 dimer interface [polypeptide binding]; other site 1052585010439 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1052585010440 Helix-turn-helix domains; Region: HTH; cl00088 1052585010441 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 1052585010442 putative dimerization interface [polypeptide binding]; other site 1052585010443 putative substrate binding pocket [chemical binding]; other site 1052585010444 Spore coat assembly protein [Cell envelope biogenesis, outer membrane]; Region: CotH; COG5337 1052585010445 Flavin Reductases; Region: FlaRed; cl00801 1052585010446 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 1052585010447 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1052585010448 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1052585010449 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1052585010450 Helix-turn-helix domains; Region: HTH; cl00088 1052585010451 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1052585010452 Chromate transporter; Region: Chromate_transp; pfam02417 1052585010453 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1052585010454 Chromate transporter; Region: Chromate_transp; pfam02417 1052585010455 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 1052585010456 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052585010457 Helix-turn-helix domains; Region: HTH; cl00088 1052585010458 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052585010459 dimerization interface [polypeptide binding]; other site 1052585010460 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1052585010461 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1052585010462 Cupin domain; Region: Cupin_2; cl09118 1052585010463 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1052585010464 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052585010465 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1052585010466 Active_site [active] 1052585010467 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 1052585010468 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1052585010469 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 1052585010470 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1052585010471 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585010472 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1052585010473 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585010474 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1052585010475 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1052585010476 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585010477 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1052585010478 Chain length determinant protein; Region: Wzz; cl15801 1052585010479 SWIM zinc finger; Region: SWIM; cl15408 1052585010480 Uncharacterized conserved protein [Function unknown]; Region: COG4715 1052585010481 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1052585010482 SNF2 Helicase protein; Region: DUF3670; pfam12419 1052585010483 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052585010484 ATP binding site [chemical binding]; other site 1052585010485 putative Mg++ binding site [ion binding]; other site 1052585010486 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052585010487 nucleotide binding region [chemical binding]; other site 1052585010488 ATP-binding site [chemical binding]; other site 1052585010489 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585010490 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1052585010491 active site 1052585010492 motif I; other site 1052585010493 motif II; other site 1052585010494 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 1052585010495 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1052585010496 Helix-turn-helix domains; Region: HTH; cl00088 1052585010497 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1052585010498 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1052585010499 dimer interface [polypeptide binding]; other site 1052585010500 ssDNA binding site [nucleotide binding]; other site 1052585010501 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052585010502 YwpF-like protein; Region: YwpF; pfam14183 1052585010503 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1052585010504 active site 1052585010505 catalytic site [active] 1052585010506 Collagen binding domain; Region: Collagen_bind; pfam05737 1052585010507 Collagen binding domain; Region: Collagen_bind; pfam05737 1052585010508 Collagen binding domain; Region: Collagen_bind; pfam05737 1052585010509 Collagen binding domain; Region: Collagen_bind; pfam05737 1052585010510 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1052585010511 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1052585010512 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1052585010513 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1052585010514 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1052585010515 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1052585010516 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1052585010517 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 1052585010518 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 1052585010519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585010520 active site 1052585010521 phosphorylation site [posttranslational modification] 1052585010522 intermolecular recognition site; other site 1052585010523 dimerization interface [polypeptide binding]; other site 1052585010524 Helix-turn-helix domains; Region: HTH; cl00088 1052585010525 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1052585010526 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052585010527 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052585010528 dimer interface [polypeptide binding]; other site 1052585010529 phosphorylation site [posttranslational modification] 1052585010530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585010531 ATP binding site [chemical binding]; other site 1052585010532 Mg2+ binding site [ion binding]; other site 1052585010533 G-X-G motif; other site 1052585010534 Response regulator receiver domain; Region: Response_reg; pfam00072 1052585010535 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585010536 active site 1052585010537 phosphorylation site [posttranslational modification] 1052585010538 intermolecular recognition site; other site 1052585010539 dimerization interface [polypeptide binding]; other site 1052585010540 Histidine kinase; Region: His_kinase; pfam06580 1052585010541 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585010542 ATP binding site [chemical binding]; other site 1052585010543 Mg2+ binding site [ion binding]; other site 1052585010544 G-X-G motif; other site 1052585010545 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 1052585010546 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1052585010547 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1052585010548 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1052585010549 binding surface 1052585010550 TPR motif; other site 1052585010551 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1052585010552 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1052585010553 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1052585010554 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1052585010555 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 1052585010556 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1052585010557 rod shape-determining protein Mbl; Provisional; Region: PRK13928 1052585010558 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 1052585010559 ATP binding site [chemical binding]; other site 1052585010560 profilin binding site; other site 1052585010561 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1052585010562 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585010563 Helix-turn-helix domains; Region: HTH; cl00088 1052585010564 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585010565 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585010566 putative substrate translocation pore; other site 1052585010567 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 1052585010568 Sodium:solute symporter family; Region: SSF; cl00456 1052585010569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585010570 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585010571 putative substrate translocation pore; other site 1052585010572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585010573 Isochorismatase family; Region: Isochorismatase; pfam00857 1052585010574 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1052585010575 catalytic triad [active] 1052585010576 conserved cis-peptide bond; other site 1052585010577 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 1052585010578 Nitrogen regulatory protein P-II; Region: P-II; cl00412 1052585010579 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1052585010580 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1052585010581 active site 1052585010582 VanZ like family; Region: VanZ; cl01971 1052585010583 Peptidase family M23; Region: Peptidase_M23; pfam01551 1052585010584 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1052585010585 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585010586 Coenzyme A binding pocket [chemical binding]; other site 1052585010587 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 1052585010588 NeuB family; Region: NeuB; cl00496 1052585010589 SAF domain; Region: SAF; cl00555 1052585010590 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1052585010591 active site 1052585010592 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1052585010593 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1052585010594 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1052585010595 putative active site [active] 1052585010596 catalytic site [active] 1052585010597 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1052585010598 putative active site [active] 1052585010599 catalytic site [active] 1052585010600 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1052585010601 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1052585010602 DNA binding residues [nucleotide binding] 1052585010603 dimer interface [polypeptide binding]; other site 1052585010604 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1052585010605 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1052585010606 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1052585010607 NAD binding site [chemical binding]; other site 1052585010608 substrate binding site [chemical binding]; other site 1052585010609 putative active site [active] 1052585010610 Predicted transcriptional regulator [Transcription]; Region: COG1959 1052585010611 Helix-turn-helix domains; Region: HTH; cl00088 1052585010612 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1052585010613 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1052585010614 subunit interactions [polypeptide binding]; other site 1052585010615 active site 1052585010616 flap region; other site 1052585010617 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1052585010618 gamma-beta subunit interface [polypeptide binding]; other site 1052585010619 alpha-beta subunit interface [polypeptide binding]; other site 1052585010620 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1052585010621 alpha-gamma subunit interface [polypeptide binding]; other site 1052585010622 beta-gamma subunit interface [polypeptide binding]; other site 1052585010623 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 1052585010624 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1052585010625 Walker A/P-loop; other site 1052585010626 ATP binding site [chemical binding]; other site 1052585010627 Q-loop/lid; other site 1052585010628 ABC transporter signature motif; other site 1052585010629 Walker B; other site 1052585010630 D-loop; other site 1052585010631 H-loop/switch region; other site 1052585010632 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1052585010633 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 1052585010634 Walker A/P-loop; other site 1052585010635 ATP binding site [chemical binding]; other site 1052585010636 Q-loop/lid; other site 1052585010637 ABC transporter signature motif; other site 1052585010638 Walker B; other site 1052585010639 D-loop; other site 1052585010640 H-loop/switch region; other site 1052585010641 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1052585010642 TM-ABC transporter signature motif; other site 1052585010643 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1052585010644 TM-ABC transporter signature motif; other site 1052585010645 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1052585010646 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1052585010647 putative ligand binding site [chemical binding]; other site 1052585010648 CsbD-like; Region: CsbD; cl15799 1052585010649 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052585010650 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1052585010651 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1052585010652 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052585010653 FeS/SAM binding site; other site 1052585010654 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1052585010655 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 1052585010656 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1052585010657 metal ion-dependent adhesion site (MIDAS); other site 1052585010658 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 1052585010659 metal ion-dependent adhesion site (MIDAS); other site 1052585010660 stage II sporulation protein D; Region: spore_II_D; TIGR02870 1052585010661 Stage II sporulation protein; Region: SpoIID; pfam08486 1052585010662 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1052585010663 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1052585010664 hinge; other site 1052585010665 active site 1052585010666 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 1052585010667 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 1052585010668 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1052585010669 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 1052585010670 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 1052585010671 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1052585010672 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 1052585010673 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1052585010674 alpha subunit interaction interface [polypeptide binding]; other site 1052585010675 Walker A motif; other site 1052585010676 ATP binding site [chemical binding]; other site 1052585010677 Walker B motif; other site 1052585010678 inhibitor binding site; inhibition site 1052585010679 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1052585010680 ATP synthase; Region: ATP-synt; cl00365 1052585010681 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 1052585010682 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1052585010683 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 1052585010684 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1052585010685 beta subunit interaction interface [polypeptide binding]; other site 1052585010686 Walker A motif; other site 1052585010687 ATP binding site [chemical binding]; other site 1052585010688 Walker B motif; other site 1052585010689 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1052585010690 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1052585010691 Plant ATP synthase F0; Region: YMF19; cl07975 1052585010692 Plant ATP synthase F0; Region: YMF19; cl07975 1052585010693 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1052585010694 ATP synthase A chain; Region: ATP-synt_A; cl00413 1052585010695 ATP synthase I chain; Region: ATP_synt_I; cl09170 1052585010696 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052585010697 active site 1052585010698 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1052585010699 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1052585010700 dimer interface [polypeptide binding]; other site 1052585010701 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1052585010702 active site 1052585010703 folate binding site [chemical binding]; other site 1052585010704 Protein of unknown function (DUF436); Region: DUF436; cl01860 1052585010705 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 1052585010706 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1052585010707 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1052585010708 active site 1052585010709 Predicted membrane protein [Function unknown]; Region: COG1971 1052585010710 Domain of unknown function DUF; Region: DUF204; pfam02659 1052585010711 Domain of unknown function DUF; Region: DUF204; pfam02659 1052585010712 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1052585010713 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1052585010714 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052585010715 HemK family putative methylases; Region: hemK_fam; TIGR00536 1052585010716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585010717 S-adenosylmethionine binding site [chemical binding]; other site 1052585010718 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1052585010719 RF-1 domain; Region: RF-1; cl02875 1052585010720 RF-1 domain; Region: RF-1; cl02875 1052585010721 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1052585010722 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052585010723 putative metal binding site [ion binding]; other site 1052585010724 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 1052585010725 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1052585010726 DNA binding residues [nucleotide binding] 1052585010727 Membrane transport protein; Region: Mem_trans; cl09117 1052585010728 malate dehydrogenase; Provisional; Region: PRK13529 1052585010729 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1052585010730 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1052585010731 NAD(P) binding site [chemical binding]; other site 1052585010732 thymidine kinase; Provisional; Region: PRK04296 1052585010733 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 1052585010734 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1052585010735 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1052585010736 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1052585010737 RNA binding site [nucleotide binding]; other site 1052585010738 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1052585010739 multimer interface [polypeptide binding]; other site 1052585010740 Walker A motif; other site 1052585010741 ATP binding site [chemical binding]; other site 1052585010742 Walker B motif; other site 1052585010743 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1052585010744 putative active site [active] 1052585010745 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1052585010746 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1052585010747 hinge; other site 1052585010748 active site 1052585010749 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1052585010750 active site 1052585010751 intersubunit interactions; other site 1052585010752 catalytic residue [active] 1052585010753 hypothetical protein; Provisional; Region: PRK08185 1052585010754 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1052585010755 intersubunit interface [polypeptide binding]; other site 1052585010756 active site 1052585010757 zinc binding site [ion binding]; other site 1052585010758 Na+ binding site [ion binding]; other site 1052585010759 Response regulator receiver domain; Region: Response_reg; pfam00072 1052585010760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585010761 active site 1052585010762 phosphorylation site [posttranslational modification] 1052585010763 intermolecular recognition site; other site 1052585010764 dimerization interface [polypeptide binding]; other site 1052585010765 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 1052585010766 CTP synthetase; Validated; Region: pyrG; PRK05380 1052585010767 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1052585010768 Catalytic site [active] 1052585010769 active site 1052585010770 UTP binding site [chemical binding]; other site 1052585010771 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1052585010772 active site 1052585010773 putative oxyanion hole; other site 1052585010774 catalytic triad [active] 1052585010775 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 1052585010776 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1052585010777 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1052585010778 FAD binding site [chemical binding]; other site 1052585010779 homotetramer interface [polypeptide binding]; other site 1052585010780 substrate binding pocket [chemical binding]; other site 1052585010781 catalytic base [active] 1052585010782 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 1052585010783 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1052585010784 Cysteine-rich domain; Region: CCG; pfam02754 1052585010785 Cysteine-rich domain; Region: CCG; pfam02754 1052585010786 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1052585010787 putative active site [active] 1052585010788 catalytic site [active] 1052585010789 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1052585010790 PLD-like domain; Region: PLDc_2; pfam13091 1052585010791 putative active site [active] 1052585010792 catalytic site [active] 1052585010793 UV-endonuclease UvdE; Region: UvdE; cl10036 1052585010794 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 1052585010795 folate binding site [chemical binding]; other site 1052585010796 NADP+ binding site [chemical binding]; other site 1052585010797 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052585010798 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1052585010799 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 1052585010800 Walker A/P-loop; other site 1052585010801 ATP binding site [chemical binding]; other site 1052585010802 Q-loop/lid; other site 1052585010803 ABC transporter signature motif; other site 1052585010804 Walker B; other site 1052585010805 D-loop; other site 1052585010806 H-loop/switch region; other site 1052585010807 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1052585010808 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1052585010809 putative active site [active] 1052585010810 catalytic site [active] 1052585010811 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1052585010812 putative active site [active] 1052585010813 catalytic site [active] 1052585010814 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1052585010815 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 1052585010816 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1052585010817 nitrate reductase, beta subunit; Region: narH; TIGR01660 1052585010818 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 1052585010819 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1052585010820 [4Fe-4S] binding site [ion binding]; other site 1052585010821 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1052585010822 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1052585010823 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1052585010824 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1052585010825 molybdopterin cofactor binding site; other site 1052585010826 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1052585010827 ligand binding site [chemical binding]; other site 1052585010828 flexible hinge region; other site 1052585010829 YwiC-like protein; Region: YwiC; pfam14256 1052585010830 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1052585010831 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1052585010832 ligand binding site [chemical binding]; other site 1052585010833 flexible hinge region; other site 1052585010834 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1052585010835 putative switch regulator; other site 1052585010836 non-specific DNA interactions [nucleotide binding]; other site 1052585010837 DNA binding site [nucleotide binding] 1052585010838 sequence specific DNA binding site [nucleotide binding]; other site 1052585010839 putative cAMP binding site [chemical binding]; other site 1052585010840 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1052585010841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585010842 putative substrate translocation pore; other site 1052585010843 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1052585010844 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 1052585010845 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1052585010846 active site 1052585010847 HIGH motif; other site 1052585010848 KMSK motif region; other site 1052585010849 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1052585010850 tRNA binding surface [nucleotide binding]; other site 1052585010851 anticodon binding site; other site 1052585010852 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 1052585010853 Bacteriocin subtilosin A; Region: Subtilosin_A; pfam11420 1052585010854 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1052585010855 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1052585010856 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052585010857 FeS/SAM binding site; other site 1052585010858 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 1052585010859 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1052585010860 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 1052585010861 Walker A/P-loop; other site 1052585010862 ATP binding site [chemical binding]; other site 1052585010863 Q-loop/lid; other site 1052585010864 ABC transporter signature motif; other site 1052585010865 Walker B; other site 1052585010866 D-loop; other site 1052585010867 H-loop/switch region; other site 1052585010868 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1052585010869 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1052585010870 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1052585010871 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1052585010872 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1052585010873 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1052585010874 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052585010875 TPR motif; other site 1052585010876 binding surface 1052585010877 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052585010878 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585010879 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1052585010880 Walker A/P-loop; other site 1052585010881 ATP binding site [chemical binding]; other site 1052585010882 Q-loop/lid; other site 1052585010883 ABC transporter signature motif; other site 1052585010884 Walker B; other site 1052585010885 D-loop; other site 1052585010886 H-loop/switch region; other site 1052585010887 Arginase family; Region: Arginase; cl00306 1052585010888 spermidine synthase; Provisional; Region: PRK00811 1052585010889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 1052585010890 Transglycosylase; Region: Transgly; cl07896 1052585010891 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1052585010892 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 1052585010893 YwhD family; Region: YwhD; pfam08741 1052585010894 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1052585010895 active site 1052585010896 putative substrate binding region [chemical binding]; other site 1052585010897 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1052585010898 active site 1 [active] 1052585010899 dimer interface [polypeptide binding]; other site 1052585010900 hexamer interface [polypeptide binding]; other site 1052585010901 active site 2 [active] 1052585010902 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585010903 Helix-turn-helix domains; Region: HTH; cl00088 1052585010904 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 1052585010905 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1052585010906 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 1052585010907 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1052585010908 active site 1052585010909 dimer interface [polypeptide binding]; other site 1052585010910 motif 1; other site 1052585010911 motif 2; other site 1052585010912 motif 3; other site 1052585010913 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1052585010914 anticodon binding site; other site 1052585010915 Uncharacterized conserved protein [Function unknown]; Region: COG3465 1052585010916 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1052585010917 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052585010918 Zn2+ binding site [ion binding]; other site 1052585010919 Mg2+ binding site [ion binding]; other site 1052585010920 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1052585010921 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1052585010922 rod shape-determining protein MreC; Provisional; Region: PRK13922 1052585010923 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1052585010924 EamA-like transporter family; Region: EamA; cl01037 1052585010925 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1052585010926 EamA-like transporter family; Region: EamA; cl01037 1052585010927 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1052585010928 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1052585010929 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052585010930 Helix-turn-helix domains; Region: HTH; cl00088 1052585010931 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1052585010932 putative dimerization interface [polypeptide binding]; other site 1052585010933 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 1052585010934 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1052585010935 Chlorite dismutase; Region: Chlor_dismutase; cl01280 1052585010936 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1052585010937 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1052585010938 putative NAD(P) binding site [chemical binding]; other site 1052585010939 putative active site [active] 1052585010940 transaminase; Reviewed; Region: PRK08068 1052585010941 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052585010942 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585010943 homodimer interface [polypeptide binding]; other site 1052585010944 catalytic residue [active] 1052585010945 H+ Antiporter protein; Region: 2A0121; TIGR00900 1052585010946 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 1052585010947 ATP-grasp domain; Region: ATP-grasp_4; cl03087 1052585010948 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1052585010949 classical (c) SDRs; Region: SDR_c; cd05233 1052585010950 NAD(P) binding site [chemical binding]; other site 1052585010951 active site 1052585010952 Cupin domain; Region: Cupin_2; cl09118 1052585010953 Cupin domain; Region: Cupin_2; cl09118 1052585010954 Prephenate dehydratase; Region: PDT; pfam00800 1052585010955 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052585010956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585010957 putative substrate translocation pore; other site 1052585010958 S-methylmethionine transporter; Provisional; Region: PRK11387 1052585010959 Spore germination protein; Region: Spore_permease; cl15802 1052585010960 Arginine degradation protein (predicted deacylase) [Amino acid transport and metabolism]; Region: RocB; COG4187 1052585010961 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 1052585010962 putative metal binding site [ion binding]; other site 1052585010963 putative dimer interface [polypeptide binding]; other site 1052585010964 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1052585010965 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1052585010966 Glutamate binding site [chemical binding]; other site 1052585010967 homodimer interface [polypeptide binding]; other site 1052585010968 NAD binding site [chemical binding]; other site 1052585010969 catalytic residues [active] 1052585010970 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1052585010971 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1052585010972 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1052585010973 NAD(P) binding site [chemical binding]; other site 1052585010974 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1052585010975 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1052585010976 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 1052585010977 NAD binding site [chemical binding]; other site 1052585010978 substrate binding site [chemical binding]; other site 1052585010979 homodimer interface [polypeptide binding]; other site 1052585010980 active site 1052585010981 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1052585010982 substrate binding site; other site 1052585010983 tetramer interface; other site 1052585010984 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 1052585010985 ligand binding site; other site 1052585010986 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 1052585010987 NeuB family; Region: NeuB; cl00496 1052585010988 SAF domain; Region: SAF; cl00555 1052585010989 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1052585010990 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052585010991 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1052585010992 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1052585010993 inhibitor-cofactor binding pocket; inhibition site 1052585010994 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585010995 catalytic residue [active] 1052585010996 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 1052585010997 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052585010998 active site 1052585010999 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; cl09881 1052585011000 Protein of unknown function (DUF423); Region: DUF423; cl01008 1052585011001 Permease family; Region: Xan_ur_permease; pfam00860 1052585011002 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 1052585011003 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1052585011004 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1052585011005 ligand binding site [chemical binding]; other site 1052585011006 active site 1052585011007 UGI interface [polypeptide binding]; other site 1052585011008 catalytic site [active] 1052585011009 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052585011010 active site 1052585011011 Helix-turn-helix domains; Region: HTH; cl00088 1052585011012 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1052585011013 substrate binding site [chemical binding]; other site 1052585011014 ATP binding site [chemical binding]; other site 1052585011015 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1052585011016 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1052585011017 substrate binding [chemical binding]; other site 1052585011018 active site 1052585011019 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1052585011020 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1052585011021 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052585011022 active site turn [active] 1052585011023 phosphorylation site [posttranslational modification] 1052585011024 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1052585011025 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 1052585011026 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1052585011027 CAT RNA binding domain; Region: CAT_RBD; cl03904 1052585011028 PRD domain; Region: PRD; cl15445 1052585011029 PRD domain; Region: PRD; cl15445 1052585011030 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1052585011031 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1052585011032 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1052585011033 putative active site [active] 1052585011034 catalytic triad [active] 1052585011035 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1052585011036 PA/protease domain interface [polypeptide binding]; other site 1052585011037 putative integrin binding motif; other site 1052585011038 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1052585011039 FlgD Ig-like domain; Region: FlgD_ig; cl15790 1052585011040 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1052585011041 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1052585011042 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1052585011043 dimer interface [polypeptide binding]; other site 1052585011044 FMN binding site [chemical binding]; other site 1052585011045 NADPH bind site [chemical binding]; other site 1052585011046 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1052585011047 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 1052585011048 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 1052585011049 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 1052585011050 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1052585011051 Subunit I/III interface [polypeptide binding]; other site 1052585011052 Subunit III/IV interface [polypeptide binding]; other site 1052585011053 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1052585011054 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1052585011055 D-pathway; other site 1052585011056 Putative ubiquinol binding site [chemical binding]; other site 1052585011057 Low-spin heme (heme b) binding site [chemical binding]; other site 1052585011058 Putative water exit pathway; other site 1052585011059 Binuclear center (heme o3/CuB) [ion binding]; other site 1052585011060 K-pathway; other site 1052585011061 Putative proton exit pathway; other site 1052585011062 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1052585011063 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 1052585011064 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1052585011065 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 1052585011066 galactose-1-phosphate uridylyltransferase, family 2; Region: galT_2; TIGR01239 1052585011067 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1052585011068 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1052585011069 galactokinase; Provisional; Region: PRK05322 1052585011070 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1052585011071 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1052585011072 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1052585011073 GtrA-like protein; Region: GtrA; cl00971 1052585011074 Helix-turn-helix domains; Region: HTH; cl00088 1052585011075 Anti-repressor SinI; Region: SinI; pfam08671 1052585011076 Protein of unknown function, DUF485; Region: DUF485; cl01231 1052585011077 Sodium:solute symporter family; Region: SSF; cl00456 1052585011078 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1052585011079 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1052585011080 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1052585011081 catalytic residues [active] 1052585011082 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1052585011083 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1052585011084 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 1052585011085 Imelysin; Region: Peptidase_M75; cl09159 1052585011086 Iron permease FTR1 family; Region: FTR1; cl00475 1052585011087 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1052585011088 thiamine phosphate binding site [chemical binding]; other site 1052585011089 active site 1052585011090 pyrophosphate binding site [ion binding]; other site 1052585011091 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1052585011092 substrate binding site [chemical binding]; other site 1052585011093 multimerization interface [polypeptide binding]; other site 1052585011094 ATP binding site [chemical binding]; other site 1052585011095 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052585011096 Helix-turn-helix domains; Region: HTH; cl00088 1052585011097 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1052585011098 putative dimerization interface [polypeptide binding]; other site 1052585011099 LrgA family; Region: LrgA; cl00608 1052585011100 LrgB-like family; Region: LrgB; cl00596 1052585011101 Uncharacterized conserved protein (DUF2196); Region: DUF2196; cl02044 1052585011102 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1052585011103 PUA domain; Region: PUA; cl00607 1052585011104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 1052585011105 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052585011106 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1052585011107 active site 1052585011108 metal binding site [ion binding]; metal-binding site 1052585011109 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 1052585011110 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1052585011111 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1052585011112 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1052585011113 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1052585011114 active site 1052585011115 catalytic residues [active] 1052585011116 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1052585011117 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052585011118 active site turn [active] 1052585011119 phosphorylation site [posttranslational modification] 1052585011120 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1052585011121 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1052585011122 CAT RNA binding domain; Region: CAT_RBD; cl03904 1052585011123 PRD domain; Region: PRD; cl15445 1052585011124 PRD domain; Region: PRD; cl15445 1052585011125 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1052585011126 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1052585011127 Ligand binding site; other site 1052585011128 metal-binding site 1052585011129 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; cl02331 1052585011130 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585011131 Helix-turn-helix domains; Region: HTH; cl00088 1052585011132 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 1052585011133 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1052585011134 active site 1052585011135 HIGH motif; other site 1052585011136 dimer interface [polypeptide binding]; other site 1052585011137 KMSKS motif; other site 1052585011138 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1052585011139 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1052585011140 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1052585011141 PA/protease domain interface [polypeptide binding]; other site 1052585011142 putative integrin binding motif; other site 1052585011143 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1052585011144 metal binding site [ion binding]; metal-binding site 1052585011145 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1052585011146 synthetase active site [active] 1052585011147 NTP binding site [chemical binding]; other site 1052585011148 metal binding site [ion binding]; metal-binding site 1052585011149 UbiA prenyltransferase family; Region: UbiA; cl00337 1052585011150 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1052585011151 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1052585011152 AMP-binding enzyme; Region: AMP-binding; cl15778 1052585011153 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 1052585011154 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1052585011155 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 1052585011156 DltD N-terminal region; Region: DltD_N; pfam04915 1052585011157 DltD central region; Region: DltD_M; pfam04918 1052585011158 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1052585011159 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1052585011160 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 1052585011161 putative NAD(P) binding site [chemical binding]; other site 1052585011162 active site 1052585011163 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1052585011164 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1052585011165 homodimer interface [polypeptide binding]; other site 1052585011166 substrate-cofactor binding pocket; other site 1052585011167 catalytic residue [active] 1052585011168 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1052585011169 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1052585011170 NAD binding site [chemical binding]; other site 1052585011171 sugar binding site [chemical binding]; other site 1052585011172 divalent metal binding site [ion binding]; other site 1052585011173 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052585011174 dimer interface [polypeptide binding]; other site 1052585011175 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1052585011176 methionine cluster; other site 1052585011177 active site 1052585011178 phosphorylation site [posttranslational modification] 1052585011179 metal binding site [ion binding]; metal-binding site 1052585011180 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1052585011181 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1052585011182 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1052585011183 active site 1052585011184 P-loop; other site 1052585011185 phosphorylation site [posttranslational modification] 1052585011186 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1052585011187 Helix-turn-helix domains; Region: HTH; cl00088 1052585011188 Helix-turn-helix domains; Region: HTH; cl00088 1052585011189 PRD domain; Region: PRD; cl15445 1052585011190 PRD domain; Region: PRD; cl15445 1052585011191 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1052585011192 P-loop; other site 1052585011193 active site 1052585011194 phosphorylation site [posttranslational modification] 1052585011195 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1052585011196 active site 1052585011197 phosphorylation site [posttranslational modification] 1052585011198 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1052585011199 active site 1052585011200 DNA binding site [nucleotide binding] 1052585011201 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1052585011202 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1052585011203 tetramer interface [polypeptide binding]; other site 1052585011204 heme binding pocket [chemical binding]; other site 1052585011205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585011206 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585011207 putative substrate translocation pore; other site 1052585011208 ABC-2 type transporter; Region: ABC2_membrane; cl11417 1052585011209 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052585011210 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585011211 Walker A/P-loop; other site 1052585011212 ATP binding site [chemical binding]; other site 1052585011213 Q-loop/lid; other site 1052585011214 ABC transporter signature motif; other site 1052585011215 Walker B; other site 1052585011216 D-loop; other site 1052585011217 H-loop/switch region; other site 1052585011218 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1052585011219 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1052585011220 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 1052585011221 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052585011222 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052585011223 DNA binding residues [nucleotide binding] 1052585011224 Sodium:solute symporter family; Region: SSF; cl00456 1052585011225 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1052585011226 putative substrate binding site [chemical binding]; other site 1052585011227 putative ATP binding site [chemical binding]; other site 1052585011228 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1052585011229 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1052585011230 The CYD subfamily implicated in cytochrome bd biogenesis. The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd...; Region: ABCC_cytochrome_bd; cd03247 1052585011231 Walker A/P-loop; other site 1052585011232 ATP binding site [chemical binding]; other site 1052585011233 Q-loop/lid; other site 1052585011234 ABC transporter signature motif; other site 1052585011235 Walker B; other site 1052585011236 D-loop; other site 1052585011237 H-loop/switch region; other site 1052585011238 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1052585011239 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 1052585011240 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585011241 ATP binding site [chemical binding]; other site 1052585011242 Q-loop/lid; other site 1052585011243 ABC transporter signature motif; other site 1052585011244 Walker B; other site 1052585011245 D-loop; other site 1052585011246 H-loop/switch region; other site 1052585011247 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1052585011248 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1052585011249 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1052585011250 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1052585011251 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 1052585011252 Peptidase family M48; Region: Peptidase_M48; cl12018 1052585011253 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1052585011254 putative active site [active] 1052585011255 putative metal binding site [ion binding]; other site 1052585011256 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 1052585011257 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1052585011258 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 1052585011259 Walker A/P-loop; other site 1052585011260 ATP binding site [chemical binding]; other site 1052585011261 Q-loop/lid; other site 1052585011262 ABC transporter signature motif; other site 1052585011263 Walker B; other site 1052585011264 D-loop; other site 1052585011265 H-loop/switch region; other site 1052585011266 TOBE domain; Region: TOBE_2; cl01440 1052585011267 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1052585011268 Helix-turn-helix domains; Region: HTH; cl00088 1052585011269 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 1052585011270 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1052585011271 NAD(P) binding site [chemical binding]; other site 1052585011272 catalytic residues [active] 1052585011273 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1052585011274 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052585011275 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052585011276 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 1052585011277 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 1052585011278 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1052585011279 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1052585011280 UDP-glucose 4-epimerase; Region: PLN02240 1052585011281 NAD binding site [chemical binding]; other site 1052585011282 homodimer interface [polypeptide binding]; other site 1052585011283 active site 1052585011284 substrate binding site [chemical binding]; other site 1052585011285 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 1052585011286 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052585011287 Histidine kinase; Region: HisKA_3; pfam07730 1052585011288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1052585011289 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052585011290 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585011291 active site 1052585011292 phosphorylation site [posttranslational modification] 1052585011293 intermolecular recognition site; other site 1052585011294 dimerization interface [polypeptide binding]; other site 1052585011295 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052585011296 DNA binding residues [nucleotide binding] 1052585011297 dimerization interface [polypeptide binding]; other site 1052585011298 peptidase T; Region: peptidase-T; TIGR01882 1052585011299 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1052585011300 metal binding site [ion binding]; metal-binding site 1052585011301 dimer interface [polypeptide binding]; other site 1052585011302 Scramblase; Region: Scramblase; cl02043 1052585011303 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1052585011304 substrate binding site [chemical binding]; other site 1052585011305 THF binding site; other site 1052585011306 zinc-binding site [ion binding]; other site 1052585011307 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1052585011308 substrate binding site [chemical binding]; other site 1052585011309 THF binding site; other site 1052585011310 zinc-binding site [ion binding]; other site 1052585011311 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 1052585011312 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 1052585011313 NAD binding site [chemical binding]; other site 1052585011314 homotetramer interface [polypeptide binding]; other site 1052585011315 homodimer interface [polypeptide binding]; other site 1052585011316 substrate binding site [chemical binding]; other site 1052585011317 active site 1052585011318 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1052585011319 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1052585011320 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1052585011321 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 1052585011322 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1052585011323 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585011324 nucleoside transporter; Region: nupC; TIGR00804 1052585011325 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1052585011326 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1052585011327 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1052585011328 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1052585011329 hydroperoxidase II; Provisional; Region: katE; PRK11249 1052585011330 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1052585011331 tetramer interface [polypeptide binding]; other site 1052585011332 heme binding pocket [chemical binding]; other site 1052585011333 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1052585011334 domain interactions; other site 1052585011335 Citrate transporter; Region: CitMHS; pfam03600 1052585011336 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 1052585011337 transmembrane helices; other site 1052585011338 Protein of unknown function (DUF421); Region: DUF421; cl00990 1052585011339 hypothetical protein; Provisional; Region: PRK11281 1052585011340 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1052585011341 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1052585011342 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052585011343 active site turn [active] 1052585011344 phosphorylation site [posttranslational modification] 1052585011345 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1052585011346 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 1052585011347 HPr interaction site; other site 1052585011348 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1052585011349 active site 1052585011350 phosphorylation site [posttranslational modification] 1052585011351 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1052585011352 CAT RNA binding domain; Region: CAT_RBD; cl03904 1052585011353 PRD domain; Region: PRD; cl15445 1052585011354 PRD domain; Region: PRD; cl15445 1052585011355 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1052585011356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585011357 putative substrate translocation pore; other site 1052585011358 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1052585011359 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1052585011360 ATP binding site [chemical binding]; other site 1052585011361 Mg++ binding site [ion binding]; other site 1052585011362 motif III; other site 1052585011363 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052585011364 nucleotide binding region [chemical binding]; other site 1052585011365 ATP-binding site [chemical binding]; other site 1052585011366 DbpA RNA binding domain; Region: DbpA; pfam03880 1052585011367 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 1052585011368 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1052585011369 active site 1052585011370 catalytic triad [active] 1052585011371 Helix-turn-helix domains; Region: HTH; cl00088 1052585011372 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 1052585011373 EamA-like transporter family; Region: EamA; cl01037 1052585011374 RHS Repeat; Region: RHS_repeat; cl11982 1052585011375 RHS Repeat; Region: RHS_repeat; cl11982 1052585011376 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1052585011377 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1052585011378 RHS Repeat; Region: RHS_repeat; cl11982 1052585011379 RHS Repeat; Region: RHS_repeat; cl11982 1052585011380 RHS Repeat; Region: RHS_repeat; cl11982 1052585011381 RHS Repeat; Region: RHS_repeat; cl11982 1052585011382 RHS Repeat; Region: RHS_repeat; cl11982 1052585011383 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1052585011384 EamA-like transporter family; Region: EamA; cl01037 1052585011385 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1052585011386 EamA-like transporter family; Region: EamA; cl01037 1052585011387 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1052585011388 Ligand Binding Site [chemical binding]; other site 1052585011389 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1052585011390 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1052585011391 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052585011392 active site turn [active] 1052585011393 phosphorylation site [posttranslational modification] 1052585011394 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1052585011395 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1052585011396 HPr interaction site; other site 1052585011397 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1052585011398 active site 1052585011399 phosphorylation site [posttranslational modification] 1052585011400 LXG domain of WXG superfamily; Region: LXG; pfam04740 1052585011401 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 1052585011402 substrate binding site [chemical binding]; other site 1052585011403 active site 1052585011404 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052585011405 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585011406 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1052585011407 HutP; Region: HutP; cl07944 1052585011408 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1052585011409 active sites [active] 1052585011410 tetramer interface [polypeptide binding]; other site 1052585011411 urocanate hydratase; Provisional; Region: PRK05414 1052585011412 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585011413 imidazolonepropionase; Validated; Region: PRK09356 1052585011414 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1052585011415 active site 1052585011416 Arginase family; Region: Arginase; cl00306 1052585011417 S-methylmethionine transporter; Provisional; Region: PRK11387 1052585011418 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1052585011419 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1052585011420 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1052585011421 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 1052585011422 nucleoside transporter; Region: nupC; TIGR00804 1052585011423 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1052585011424 Nucleoside recognition; Region: Gate; cl00486 1052585011425 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1052585011426 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1052585011427 intersubunit interface [polypeptide binding]; other site 1052585011428 active site 1052585011429 catalytic residue [active] 1052585011430 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1052585011431 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 1052585011432 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1052585011433 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1052585011434 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1052585011435 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1052585011436 Ethanolamine utilisation protein, EutH; Region: EutH; cl01248 1052585011437 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 1052585011438 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1052585011439 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1052585011440 metal binding site [ion binding]; metal-binding site 1052585011441 dimer interface [polypeptide binding]; other site 1052585011442 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1052585011443 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 1052585011444 Walker A/P-loop; other site 1052585011445 ATP binding site [chemical binding]; other site 1052585011446 Q-loop/lid; other site 1052585011447 ABC transporter signature motif; other site 1052585011448 Walker B; other site 1052585011449 D-loop; other site 1052585011450 H-loop/switch region; other site 1052585011451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052585011452 dimer interface [polypeptide binding]; other site 1052585011453 conserved gate region; other site 1052585011454 putative PBP binding loops; other site 1052585011455 ABC-ATPase subunit interface; other site 1052585011456 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1052585011457 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1052585011458 substrate binding pocket [chemical binding]; other site 1052585011459 membrane-bound complex binding site; other site 1052585011460 hinge residues; other site 1052585011461 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585011462 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1052585011463 Coenzyme A binding pocket [chemical binding]; other site 1052585011464 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1052585011465 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1052585011466 active site 1052585011467 non-prolyl cis peptide bond; other site 1052585011468 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1052585011469 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1052585011470 active site 1052585011471 sugar phosphate phosphatase; Provisional; Region: PRK10513 1052585011472 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585011473 active site 1052585011474 motif I; other site 1052585011475 motif II; other site 1052585011476 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052585011477 Protein of unknown function (DUF3255); Region: DUF3255; pfam11631 1052585011478 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1052585011479 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1052585011480 putative ligand binding residues [chemical binding]; other site 1052585011481 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 1052585011482 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052585011483 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 1052585011484 Walker A/P-loop; other site 1052585011485 ATP binding site [chemical binding]; other site 1052585011486 Q-loop/lid; other site 1052585011487 ABC transporter signature motif; other site 1052585011488 Walker B; other site 1052585011489 D-loop; other site 1052585011490 H-loop/switch region; other site 1052585011491 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1052585011492 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585011493 ATP binding site [chemical binding]; other site 1052585011494 Mg2+ binding site [ion binding]; other site 1052585011495 G-X-G motif; other site 1052585011496 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052585011497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585011498 active site 1052585011499 phosphorylation site [posttranslational modification] 1052585011500 intermolecular recognition site; other site 1052585011501 dimerization interface [polypeptide binding]; other site 1052585011502 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052585011503 DNA binding site [nucleotide binding] 1052585011504 hypothetical protein; Provisional; Region: PRK08185 1052585011505 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1052585011506 intersubunit interface [polypeptide binding]; other site 1052585011507 active site 1052585011508 zinc binding site [ion binding]; other site 1052585011509 Na+ binding site [ion binding]; other site 1052585011510 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1052585011511 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1052585011512 Metal-binding active site; metal-binding site 1052585011513 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1052585011514 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1052585011515 DNA interaction; other site 1052585011516 Metal-binding active site; metal-binding site 1052585011517 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052585011518 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585011519 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 1052585011520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585011521 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585011522 putative substrate translocation pore; other site 1052585011523 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1052585011524 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1052585011525 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1052585011526 PYR/PP interface [polypeptide binding]; other site 1052585011527 dimer interface [polypeptide binding]; other site 1052585011528 TPP binding site [chemical binding]; other site 1052585011529 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 1052585011530 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1052585011531 TPP-binding site; other site 1052585011532 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1052585011533 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1052585011534 substrate binding site [chemical binding]; other site 1052585011535 ATP binding site [chemical binding]; other site 1052585011536 KduI/IolB family; Region: KduI; cl01508 1052585011537 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1052585011538 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1052585011539 tetrameric interface [polypeptide binding]; other site 1052585011540 NAD binding site [chemical binding]; other site 1052585011541 catalytic residues [active] 1052585011542 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1052585011543 Helix-turn-helix domains; Region: HTH; cl00088 1052585011544 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1052585011545 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1052585011546 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052585011547 active site 1052585011548 catalytic tetrad [active] 1052585011549 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 1052585011550 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1052585011551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585011552 putative substrate translocation pore; other site 1052585011553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585011554 heat shock protein 90; Provisional; Region: PRK05218 1052585011555 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1052585011556 short chain dehydrogenase; Validated; Region: PRK08589 1052585011557 classical (c) SDRs; Region: SDR_c; cd05233 1052585011558 NAD(P) binding site [chemical binding]; other site 1052585011559 active site 1052585011560 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585011561 Helix-turn-helix domains; Region: HTH; cl00088 1052585011562 Helix-turn-helix domains; Region: HTH; cl00088 1052585011563 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1052585011564 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 1052585011565 NAD(P) binding site [chemical binding]; other site 1052585011566 catalytic residues [active] 1052585011567 RDD family; Region: RDD; cl00746 1052585011568 RDD family; Region: RDD; cl00746 1052585011569 Predicted membrane protein [Function unknown]; Region: COG2311 1052585011570 Protein of unknown function (DUF418); Region: DUF418; cl12135 1052585011571 Cupin domain; Region: Cupin_2; cl09118 1052585011572 Cupin domain; Region: Cupin_2; cl09118 1052585011573 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052585011574 Helix-turn-helix domains; Region: HTH; cl00088 1052585011575 short chain dehydrogenase; Provisional; Region: PRK07109 1052585011576 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1052585011577 putative NAD(P) binding site [chemical binding]; other site 1052585011578 active site 1052585011579 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585011580 Helix-turn-helix domains; Region: HTH; cl00088 1052585011581 LrgA family; Region: LrgA; cl00608 1052585011582 LrgB-like family; Region: LrgB; cl00596 1052585011583 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1052585011584 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1052585011585 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1052585011586 Glycerate kinase family; Region: Gly_kinase; cl00841 1052585011587 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1052585011588 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585011589 DNA-binding site [nucleotide binding]; DNA binding site 1052585011590 FCD domain; Region: FCD; cl11656 1052585011591 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1052585011592 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1052585011593 N- and C-terminal domain interface [polypeptide binding]; other site 1052585011594 putative active site [active] 1052585011595 catalytic site [active] 1052585011596 metal binding site [ion binding]; metal-binding site 1052585011597 carbohydrate binding site [chemical binding]; other site 1052585011598 ATP binding site [chemical binding]; other site 1052585011599 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 1052585011600 gluconate transporter; Region: gntP; TIGR00791 1052585011601 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585011602 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1052585011603 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1052585011604 peroxiredoxin; Region: AhpC; TIGR03137 1052585011605 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1052585011606 dimer interface [polypeptide binding]; other site 1052585011607 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1052585011608 catalytic triad [active] 1052585011609 peroxidatic and resolving cysteines [active] 1052585011610 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1052585011611 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1052585011612 catalytic residue [active] 1052585011613 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1052585011614 catalytic residues [active] 1052585011615 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052585011616 Fic family protein [Function unknown]; Region: COG3177 1052585011617 Fic/DOC family; Region: Fic; cl00960 1052585011618 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1052585011619 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1052585011620 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1052585011621 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1052585011622 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052585011623 active site turn [active] 1052585011624 phosphorylation site [posttranslational modification] 1052585011625 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 1052585011626 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 1052585011627 HPr interaction site; other site 1052585011628 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1052585011629 active site 1052585011630 phosphorylation site [posttranslational modification] 1052585011631 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1052585011632 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052585011633 DNA-binding site [nucleotide binding]; DNA binding site 1052585011634 UTRA domain; Region: UTRA; cl01230 1052585011635 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1052585011636 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585011637 Walker A/P-loop; other site 1052585011638 ATP binding site [chemical binding]; other site 1052585011639 ABC transporter signature motif; other site 1052585011640 Walker B; other site 1052585011641 D-loop; other site 1052585011642 H-loop/switch region; other site 1052585011643 peptide modification radical SAM enzyme, YydG family; Region: rSAM_yydG; TIGR04078 1052585011644 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052585011645 FeS/SAM binding site; other site 1052585011646 exported signaling peptide, YydF/SAG_2028 family; Region: expor_sig_YdyF; TIGR04077 1052585011647 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 1052585011648 AAA ATPase domain; Region: AAA_15; pfam13175 1052585011649 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585011650 Walker A/P-loop; other site 1052585011651 ATP binding site [chemical binding]; other site 1052585011652 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585011653 ABC transporter signature motif; other site 1052585011654 Walker B; other site 1052585011655 D-loop; other site 1052585011656 H-loop/switch region; other site 1052585011657 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1052585011658 active site 1052585011659 metal binding site [ion binding]; metal-binding site 1052585011660 Transcription factor IIA, alpha/beta subunit; Region: TFIIA; pfam03153 1052585011661 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 1052585011662 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 1052585011663 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 1052585011664 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 1052585011665 NAD binding site [chemical binding]; other site 1052585011666 catalytic Zn binding site [ion binding]; other site 1052585011667 structural Zn binding site [ion binding]; other site 1052585011668 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1052585011669 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1052585011670 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585011671 Coenzyme A binding pocket [chemical binding]; other site 1052585011672 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052585011673 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052585011674 Arginase family; Region: Arginase; cl00306 1052585011675 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 1052585011676 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1052585011677 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052585011678 inhibitor-cofactor binding pocket; inhibition site 1052585011679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052585011680 catalytic residue [active] 1052585011681 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1052585011682 sensory histidine kinase AtoS; Provisional; Region: PRK11360 1052585011683 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1052585011684 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052585011685 Walker A motif; other site 1052585011686 ATP binding site [chemical binding]; other site 1052585011687 Walker B motif; other site 1052585011688 arginine finger; other site 1052585011689 Helix-turn-helix domains; Region: HTH; cl00088 1052585011690 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052585011691 dimerization interface [polypeptide binding]; other site 1052585011692 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052585011693 dimer interface [polypeptide binding]; other site 1052585011694 phosphorylation site [posttranslational modification] 1052585011695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585011696 ATP binding site [chemical binding]; other site 1052585011697 Mg2+ binding site [ion binding]; other site 1052585011698 G-X-G motif; other site 1052585011699 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052585011700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585011701 active site 1052585011702 phosphorylation site [posttranslational modification] 1052585011703 intermolecular recognition site; other site 1052585011704 dimerization interface [polypeptide binding]; other site 1052585011705 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052585011706 DNA binding site [nucleotide binding] 1052585011707 Predicted membrane protein [Function unknown]; Region: COG3212 1052585011708 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 1052585011709 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 1052585011710 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 1052585011711 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 1052585011712 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 1052585011713 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 1052585011714 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 1052585011715 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1052585011716 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1052585011717 protein binding site [polypeptide binding]; other site 1052585011718 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052585011719 YycH protein; Region: YycI; cl02015 1052585011720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1052585011721 YycH protein; Region: YycH; pfam07435 1052585011722 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1052585011723 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052585011724 dimerization interface [polypeptide binding]; other site 1052585011725 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1052585011726 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1052585011727 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052585011728 dimer interface [polypeptide binding]; other site 1052585011729 phosphorylation site [posttranslational modification] 1052585011730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052585011731 ATP binding site [chemical binding]; other site 1052585011732 Mg2+ binding site [ion binding]; other site 1052585011733 G-X-G motif; other site 1052585011734 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052585011735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052585011736 active site 1052585011737 phosphorylation site [posttranslational modification] 1052585011738 intermolecular recognition site; other site 1052585011739 dimerization interface [polypeptide binding]; other site 1052585011740 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052585011741 DNA binding site [nucleotide binding] 1052585011742 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1052585011743 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1052585011744 GDP-binding site [chemical binding]; other site 1052585011745 ACT binding site; other site 1052585011746 IMP binding site; other site 1052585011747 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052585011748 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1052585011749 active site 1052585011750 metal binding site [ion binding]; metal-binding site 1052585011751 replicative DNA helicase; Provisional; Region: PRK05748 1052585011752 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1052585011753 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1052585011754 Walker A motif; other site 1052585011755 ATP binding site [chemical binding]; other site 1052585011756 Walker B motif; other site 1052585011757 DNA binding loops [nucleotide binding] 1052585011758 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 1052585011759 YycC-like protein; Region: YycC; pfam14174 1052585011760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585011761 cyanate transporter; Region: CynX; TIGR00896 1052585011762 putative substrate translocation pore; other site 1052585011763 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 1052585011764 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1052585011765 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1052585011766 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1052585011767 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1052585011768 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1052585011769 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1052585011770 DHH family; Region: DHH; pfam01368 1052585011771 DHHA1 domain; Region: DHHA1; pfam02272 1052585011772 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 1052585011773 Coat F domain; Region: Coat_F; cl15836 1052585011774 Helix-turn-helix domains; Region: HTH; cl00088 1052585011775 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1052585011776 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1052585011777 DHHA2 domain; Region: DHHA2; pfam02833 1052585011778 ANTAR domain; Region: ANTAR; cl04297 1052585011779 D-galactonate transporter; Region: 2A0114; TIGR00893 1052585011780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585011781 putative substrate translocation pore; other site 1052585011782 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1052585011783 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1052585011784 DNA binding residues [nucleotide binding] 1052585011785 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1052585011786 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1052585011787 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1052585011788 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1052585011789 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1052585011790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585011791 putative substrate translocation pore; other site 1052585011792 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052585011793 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052585011794 Helix-turn-helix domains; Region: HTH; cl00088 1052585011795 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1052585011796 putative dimerization interface [polypeptide binding]; other site 1052585011797 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585011798 Coenzyme A binding pocket [chemical binding]; other site 1052585011799 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052585011800 Helix-turn-helix domains; Region: HTH; cl00088 1052585011801 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052585011802 Helix-turn-helix domains; Region: HTH; cl00088 1052585011803 Predicted acetyltransferase [General function prediction only]; Region: COG3153 1052585011804 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052585011805 Coenzyme A binding pocket [chemical binding]; other site 1052585011806 Predicted membrane protein [Function unknown]; Region: COG2364 1052585011807 Protein of unknown function, DUF606; Region: DUF606; cl01273 1052585011808 Protein of unknown function, DUF606; Region: DUF606; cl01273 1052585011809 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052585011810 dimerization interface [polypeptide binding]; other site 1052585011811 putative DNA binding site [nucleotide binding]; other site 1052585011812 putative Zn2+ binding site [ion binding]; other site 1052585011813 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1052585011814 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1052585011815 catalytic residues [active] 1052585011816 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1052585011817 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1052585011818 CAAX protease self-immunity; Region: Abi; cl00558 1052585011819 benzoate transport; Region: 2A0115; TIGR00895 1052585011820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585011821 putative substrate translocation pore; other site 1052585011822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052585011823 maltose O-acetyltransferase; Provisional; Region: PRK10092 1052585011824 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1052585011825 active site 1052585011826 substrate binding site [chemical binding]; other site 1052585011827 trimer interface [polypeptide binding]; other site 1052585011828 CoA binding site [chemical binding]; other site 1052585011829 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 1052585011830 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052585011831 putative metal binding site [ion binding]; other site 1052585011832 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052585011833 DNA binding site [nucleotide binding] 1052585011834 domain linker motif; other site 1052585011835 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1052585011836 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1052585011837 putative dimerization interface [polypeptide binding]; other site 1052585011838 putative ligand binding site [chemical binding]; other site 1052585011839 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1052585011840 active site 1052585011841 DNA binding site [nucleotide binding] 1052585011842 putative phosphate binding site [ion binding]; other site 1052585011843 putative catalytic site [active] 1052585011844 metal binding site A [ion binding]; metal-binding site 1052585011845 AP binding site [nucleotide binding]; other site 1052585011846 metal binding site B [ion binding]; metal-binding site 1052585011847 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1052585011848 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1052585011849 dimer interface [polypeptide binding]; other site 1052585011850 ssDNA binding site [nucleotide binding]; other site 1052585011851 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052585011852 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 1052585011853 YchF GTPase; Region: YchF; cd01900 1052585011854 Switch II region; other site 1052585011855 G3 box; other site 1052585011856 GTP/Mg2+ binding site [chemical binding]; other site 1052585011857 G4 box; other site 1052585011858 G5 box; other site 1052585011859 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1052585011860 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585011861 G1 box; other site 1052585011862 GTP/Mg2+ binding site [chemical binding]; other site 1052585011863 G2 box; other site 1052585011864 Switch I region; other site 1052585011865 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1052585011866 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1052585011867 putative [4Fe-4S] binding site [ion binding]; other site 1052585011868 putative molybdopterin cofactor binding site [chemical binding]; other site 1052585011869 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1052585011870 molybdopterin cofactor binding site; other site 1052585011871 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 1052585011872 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1052585011873 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 1052585011874 ParB-like partition proteins; Region: parB_part; TIGR00180 1052585011875 ParB-like nuclease domain; Region: ParBc; cl02129 1052585011876 KorB domain; Region: KorB; pfam08535 1052585011877 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1052585011878 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 1052585011879 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 1052585011880 ParB-like partition proteins; Region: parB_part; TIGR00180 1052585011881 ParB-like nuclease domain; Region: ParBc; cl02129 1052585011882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052585011883 S-adenosylmethionine binding site [chemical binding]; other site 1052585011884 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1052585011885 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052585011886 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1052585011887 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1052585011888 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1052585011889 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1052585011890 G1 box; other site 1052585011891 GTP/Mg2+ binding site [chemical binding]; other site 1052585011892 Switch I region; other site 1052585011893 G2 box; other site 1052585011894 Switch II region; other site 1052585011895 G3 box; other site 1052585011896 G4 box; other site 1052585011897 G5 box; other site 1052585011898 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1052585011899 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1052585011900 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1052585011901 G-X-X-G motif; other site 1052585011902 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1052585011903 RxxxH motif; other site 1052585011904 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1052585011905 Ribonuclease P; Region: Ribonuclease_P; cl00457