-- dump date 20120504_134329 -- class Genbank::misc_feature -- table misc_feature_note -- id note 655816000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 655816000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 655816000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816000004 Walker A motif; other site 655816000005 ATP binding site [chemical binding]; other site 655816000006 Walker B motif; other site 655816000007 arginine finger; other site 655816000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 655816000009 DnaA box-binding interface [nucleotide binding]; other site 655816000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 655816000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 655816000012 putative DNA binding surface [nucleotide binding]; other site 655816000013 dimer interface [polypeptide binding]; other site 655816000014 beta-clamp/clamp loader binding surface; other site 655816000015 beta-clamp/translesion DNA polymerase binding surface; other site 655816000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 655816000017 recF protein; Region: recf; TIGR00611 655816000018 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 655816000019 Walker A/P-loop; other site 655816000020 ATP binding site [chemical binding]; other site 655816000021 Q-loop/lid; other site 655816000022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816000023 ABC transporter signature motif; other site 655816000024 Walker B; other site 655816000025 D-loop; other site 655816000026 H-loop/switch region; other site 655816000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 655816000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816000029 ATP binding site [chemical binding]; other site 655816000030 Mg2+ binding site [ion binding]; other site 655816000031 G-X-G motif; other site 655816000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 655816000033 anchoring element; other site 655816000034 dimer interface [polypeptide binding]; other site 655816000035 ATP binding site [chemical binding]; other site 655816000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 655816000037 active site 655816000038 putative metal-binding site [ion binding]; other site 655816000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 655816000040 DNA gyrase subunit A; Validated; Region: PRK05560 655816000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 655816000042 CAP-like domain; other site 655816000043 active site 655816000044 primary dimer interface [polypeptide binding]; other site 655816000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 655816000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 655816000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 655816000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 655816000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 655816000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 655816000051 YaaC-like Protein; Region: YaaC; pfam14175 655816000052 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 655816000053 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 655816000054 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 655816000055 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 655816000056 active site 655816000057 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 655816000058 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 655816000059 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 655816000060 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 655816000061 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 655816000062 active site 655816000063 multimer interface [polypeptide binding]; other site 655816000064 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 655816000065 predicted active site [active] 655816000066 catalytic triad [active] 655816000067 seryl-tRNA synthetase; Provisional; Region: PRK05431 655816000068 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 655816000069 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 655816000070 dimer interface [polypeptide binding]; other site 655816000071 active site 655816000072 motif 1; other site 655816000073 motif 2; other site 655816000074 motif 3; other site 655816000075 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 655816000076 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 655816000077 Substrate-binding site [chemical binding]; other site 655816000078 Substrate specificity [chemical binding]; other site 655816000079 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 655816000080 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 655816000081 Substrate-binding site [chemical binding]; other site 655816000082 Substrate specificity [chemical binding]; other site 655816000083 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 655816000084 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 655816000085 putative peptidoglycan binding site; other site 655816000086 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 655816000087 putative peptidoglycan binding site; other site 655816000088 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 655816000089 active site 655816000090 Isochorismatase family; Region: Isochorismatase; pfam00857 655816000091 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 655816000092 catalytic triad [active] 655816000093 conserved cis-peptide bond; other site 655816000094 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 655816000095 nucleoside/Zn binding site; other site 655816000096 dimer interface [polypeptide binding]; other site 655816000097 catalytic motif [active] 655816000098 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 655816000099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816000100 Walker A motif; other site 655816000101 ATP binding site [chemical binding]; other site 655816000102 Walker B motif; other site 655816000103 arginine finger; other site 655816000104 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 655816000105 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 655816000106 recombination protein RecR; Reviewed; Region: recR; PRK00076 655816000107 RecR protein; Region: RecR; pfam02132 655816000108 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 655816000109 putative active site [active] 655816000110 putative metal-binding site [ion binding]; other site 655816000111 tetramer interface [polypeptide binding]; other site 655816000112 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 655816000113 SigmaK-factor processing regulatory protein BofA; Region: BofA; cl06466 655816000114 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 655816000115 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 655816000116 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 655816000117 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 655816000118 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 655816000119 homodimer interface [polypeptide binding]; other site 655816000120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816000121 catalytic residue [active] 655816000122 thymidylate kinase; Validated; Region: tmk; PRK00698 655816000123 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 655816000124 TMP-binding site; other site 655816000125 ATP-binding site [chemical binding]; other site 655816000126 Nitrogen regulatory protein P-II; Region: P-II; cl00412 655816000127 Protein of unknown function (DUF327); Region: DUF327; cl00753 655816000128 DNA polymerase III subunit delta'; Validated; Region: PRK08058 655816000129 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816000130 PSP1 C-terminal conserved region; Region: PSP1; cl00770 655816000131 TSC-22/dip/bun family; Region: TSC22; cl01853 655816000132 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 655816000133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816000134 S-adenosylmethionine binding site [chemical binding]; other site 655816000135 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 655816000136 GIY-YIG motif/motif A; other site 655816000137 putative active site [active] 655816000138 putative metal binding site [ion binding]; other site 655816000139 Predicted methyltransferases [General function prediction only]; Region: COG0313 655816000140 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 655816000141 stage V sporulation protein T; Region: spore_V_T; TIGR02851 655816000142 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 655816000143 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 655816000144 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 655816000145 active site 655816000146 HIGH motif; other site 655816000147 KMSKS motif; other site 655816000148 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 655816000149 tRNA binding surface [nucleotide binding]; other site 655816000150 anticodon binding site; other site 655816000151 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 655816000152 dimer interface [polypeptide binding]; other site 655816000153 putative tRNA-binding site [nucleotide binding]; other site 655816000154 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 655816000155 active site 655816000156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 655816000157 Domain of unknown function (DUF348); Region: DUF348; pfam03990 655816000158 Domain of unknown function (DUF348); Region: DUF348; pfam03990 655816000159 Domain of unknown function (DUF348); Region: DUF348; pfam03990 655816000160 G5 domain; Region: G5; pfam07501 655816000161 3D domain; Region: 3D; cl01439 655816000162 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 655816000163 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 655816000164 putative active site [active] 655816000165 putative metal binding site [ion binding]; other site 655816000166 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 655816000167 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816000168 S-adenosylmethionine binding site [chemical binding]; other site 655816000169 YabG peptidase U57; Region: Peptidase_U57; cl05250 655816000170 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 655816000171 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 655816000172 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 655816000173 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 655816000174 pur operon repressor, Bacillus subtilis type; Region: purR_Bsub; TIGR01743 655816000175 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 655816000176 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 655816000177 active site 655816000178 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 655816000179 homotrimer interaction site [polypeptide binding]; other site 655816000180 putative active site [active] 655816000181 SpoVG; Region: SpoVG; cl00915 655816000182 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 655816000183 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 655816000184 Substrate binding site; other site 655816000185 Mg++ binding site; other site 655816000186 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 655816000187 active site 655816000188 substrate binding site [chemical binding]; other site 655816000189 CoA binding site [chemical binding]; other site 655816000190 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 655816000191 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 655816000192 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 655816000193 active site 655816000194 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 655816000195 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 655816000196 5S rRNA interface [nucleotide binding]; other site 655816000197 CTC domain interface [polypeptide binding]; other site 655816000198 L16 interface [polypeptide binding]; other site 655816000199 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 655816000200 putative active site [active] 655816000201 catalytic residue [active] 655816000202 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 655816000203 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 655816000204 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 655816000205 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 655816000206 ATP binding site [chemical binding]; other site 655816000207 putative Mg++ binding site [ion binding]; other site 655816000208 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655816000209 nucleotide binding region [chemical binding]; other site 655816000210 ATP-binding site [chemical binding]; other site 655816000211 TRCF domain; Region: TRCF; cl04088 655816000212 stage V sporulation protein T; Region: spore_V_T; TIGR02851 655816000213 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 655816000214 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 655816000215 MatE; Region: MatE; cl10513 655816000216 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 655816000217 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 655816000218 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 655816000219 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 655816000220 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 655816000221 RNA binding surface [nucleotide binding]; other site 655816000222 YabP family; Region: YabP; cl06766 655816000223 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 655816000224 Septum formation initiator; Region: DivIC; cl11433 655816000225 hypothetical protein; Provisional; Region: PRK08582 655816000226 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 655816000227 RNA binding site [nucleotide binding]; other site 655816000228 stage II sporulation protein E; Region: spore_II_E; TIGR02865 655816000229 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 655816000230 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 655816000231 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 655816000232 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 655816000233 metal ion-dependent adhesion site (MIDAS); other site 655816000234 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 655816000235 active site 655816000236 ATP binding site [chemical binding]; other site 655816000237 substrate binding site [chemical binding]; other site 655816000238 activation loop (A-loop); other site 655816000239 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 655816000240 Ligand Binding Site [chemical binding]; other site 655816000241 B3/4 domain; Region: B3_4; cl11458 655816000242 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 655816000243 active site 655816000244 FtsH Extracellular; Region: FtsH_ext; pfam06480 655816000245 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 655816000246 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816000247 Walker A motif; other site 655816000248 ATP binding site [chemical binding]; other site 655816000249 Walker B motif; other site 655816000250 arginine finger; other site 655816000251 Peptidase family M41; Region: Peptidase_M41; pfam01434 655816000252 Type III pantothenate kinase; Region: Pan_kinase; cl09130 655816000253 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 655816000254 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 655816000255 dimerization interface [polypeptide binding]; other site 655816000256 domain crossover interface; other site 655816000257 redox-dependent activation switch; other site 655816000258 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 655816000259 PPIC-type PPIASE domain; Region: Rotamase; cl08278 655816000260 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 655816000261 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 655816000262 dimer interface [polypeptide binding]; other site 655816000263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816000264 catalytic residue [active] 655816000265 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 655816000266 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 655816000267 chorismate binding enzyme; Region: Chorismate_bind; cl10555 655816000268 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 655816000269 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 655816000270 glutamine binding [chemical binding]; other site 655816000271 catalytic triad [active] 655816000272 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 655816000273 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816000274 catalytic residue [active] 655816000275 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 655816000276 dihydropteroate synthase; Region: DHPS; TIGR01496 655816000277 substrate binding pocket [chemical binding]; other site 655816000278 dimer interface [polypeptide binding]; other site 655816000279 inhibitor binding site; inhibition site 655816000280 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 655816000281 homooctamer interface [polypeptide binding]; other site 655816000282 active site 655816000283 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 655816000284 catalytic center binding site [active] 655816000285 ATP binding site [chemical binding]; other site 655816000286 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655816000287 non-specific DNA binding site [nucleotide binding]; other site 655816000288 salt bridge; other site 655816000289 sequence-specific DNA binding site [nucleotide binding]; other site 655816000290 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 655816000291 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 655816000292 FMN binding site [chemical binding]; other site 655816000293 active site 655816000294 catalytic residues [active] 655816000295 substrate binding site [chemical binding]; other site 655816000296 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 655816000297 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 655816000298 dimer interface [polypeptide binding]; other site 655816000299 putative anticodon binding site; other site 655816000300 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 655816000301 motif 1; other site 655816000302 active site 655816000303 motif 2; other site 655816000304 motif 3; other site 655816000305 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 655816000306 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 655816000307 UvrB/uvrC motif; Region: UVR; pfam02151 655816000308 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 655816000309 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 655816000310 ADP binding site [chemical binding]; other site 655816000311 phosphagen binding site; other site 655816000312 substrate specificity loop; other site 655816000313 Clp protease ATP binding subunit; Region: clpC; CHL00095 655816000314 Clp amino terminal domain; Region: Clp_N; pfam02861 655816000315 Clp amino terminal domain; Region: Clp_N; pfam02861 655816000316 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816000317 Walker A motif; other site 655816000318 ATP binding site [chemical binding]; other site 655816000319 Walker B motif; other site 655816000320 arginine finger; other site 655816000321 UvrB/uvrC motif; Region: UVR; pfam02151 655816000322 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816000323 Walker A motif; other site 655816000324 ATP binding site [chemical binding]; other site 655816000325 Walker B motif; other site 655816000326 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 655816000327 DNA repair protein RadA; Provisional; Region: PRK11823 655816000328 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 655816000329 Walker A motif/ATP binding site; other site 655816000330 ATP binding site [chemical binding]; other site 655816000331 Walker B motif; other site 655816000332 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 655816000333 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 655816000334 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 655816000335 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 655816000336 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 655816000337 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 655816000338 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 655816000339 putative active site [active] 655816000340 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 655816000341 substrate binding site; other site 655816000342 dimer interface; other site 655816000343 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 655816000344 homotrimer interaction site [polypeptide binding]; other site 655816000345 zinc binding site [ion binding]; other site 655816000346 CDP-binding sites; other site 655816000347 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 655816000348 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 655816000349 active site 655816000350 HIGH motif; other site 655816000351 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 655816000352 active site 655816000353 KMSKS motif; other site 655816000354 serine O-acetyltransferase; Region: cysE; TIGR01172 655816000355 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 655816000356 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 655816000357 trimer interface [polypeptide binding]; other site 655816000358 active site 655816000359 substrate binding site [chemical binding]; other site 655816000360 CoA binding site [chemical binding]; other site 655816000361 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 655816000362 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 655816000363 active site 655816000364 HIGH motif; other site 655816000365 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 655816000366 KMSKS motif; other site 655816000367 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 655816000368 tRNA binding surface [nucleotide binding]; other site 655816000369 anticodon binding site; other site 655816000370 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 655816000371 active site 655816000372 metal binding site [ion binding]; metal-binding site 655816000373 dimerization interface [polypeptide binding]; other site 655816000374 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 655816000375 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 655816000376 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 655816000377 YacP-like NYN domain; Region: NYN_YacP; cl01491 655816000378 RNA polymerase factor sigma-70; Validated; Region: PRK08295 655816000379 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655816000380 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 655816000381 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 655816000382 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 655816000383 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 655816000384 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 655816000385 putative homodimer interface [polypeptide binding]; other site 655816000386 KOW motif; Region: KOW; cl00354 655816000387 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 655816000388 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 655816000389 23S rRNA interface [nucleotide binding]; other site 655816000390 L7/L12 interface [polypeptide binding]; other site 655816000391 putative thiostrepton binding site; other site 655816000392 L25 interface [polypeptide binding]; other site 655816000393 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 655816000394 mRNA/rRNA interface [nucleotide binding]; other site 655816000395 L10 leader; ribosomal protein gene, untranslated leader; autoregulatory structure; BSUW23_misc_RNA_3 655816000396 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 655816000397 23S rRNA interface [nucleotide binding]; other site 655816000398 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 655816000399 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 655816000400 core dimer interface [polypeptide binding]; other site 655816000401 peripheral dimer interface [polypeptide binding]; other site 655816000402 L10 interface [polypeptide binding]; other site 655816000403 L11 interface [polypeptide binding]; other site 655816000404 putative EF-Tu interaction site [polypeptide binding]; other site 655816000405 putative EF-G interaction site [polypeptide binding]; other site 655816000406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816000407 S-adenosylmethionine binding site [chemical binding]; other site 655816000408 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 655816000409 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 655816000410 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 655816000411 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 655816000412 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 655816000413 RPB1 interaction site [polypeptide binding]; other site 655816000414 RPB10 interaction site [polypeptide binding]; other site 655816000415 RPB11 interaction site [polypeptide binding]; other site 655816000416 RPB3 interaction site [polypeptide binding]; other site 655816000417 RPB12 interaction site [polypeptide binding]; other site 655816000418 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 655816000419 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 655816000420 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 655816000421 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 655816000422 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 655816000423 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 655816000424 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 655816000425 G-loop; other site 655816000426 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 655816000427 DNA binding site [nucleotide binding] 655816000428 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 655816000429 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 655816000430 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 655816000431 S17 interaction site [polypeptide binding]; other site 655816000432 S8 interaction site; other site 655816000433 16S rRNA interaction site [nucleotide binding]; other site 655816000434 streptomycin interaction site [chemical binding]; other site 655816000435 23S rRNA interaction site [nucleotide binding]; other site 655816000436 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 655816000437 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 655816000438 elongation factor G; Reviewed; Region: PRK00007 655816000439 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 655816000440 G1 box; other site 655816000441 putative GEF interaction site [polypeptide binding]; other site 655816000442 GTP/Mg2+ binding site [chemical binding]; other site 655816000443 Switch I region; other site 655816000444 G2 box; other site 655816000445 G3 box; other site 655816000446 Switch II region; other site 655816000447 G4 box; other site 655816000448 G5 box; other site 655816000449 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 655816000450 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 655816000451 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 655816000452 elongation factor Tu; Reviewed; Region: PRK00049 655816000453 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 655816000454 G1 box; other site 655816000455 GEF interaction site [polypeptide binding]; other site 655816000456 GTP/Mg2+ binding site [chemical binding]; other site 655816000457 Switch I region; other site 655816000458 G2 box; other site 655816000459 G3 box; other site 655816000460 Switch II region; other site 655816000461 G4 box; other site 655816000462 G5 box; other site 655816000463 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 655816000464 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 655816000465 Antibiotic Binding Site [chemical binding]; other site 655816000466 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 655816000467 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 655816000468 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 655816000469 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 655816000470 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 655816000471 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 655816000472 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 655816000473 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 655816000474 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 655816000475 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 655816000476 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 655816000477 putative translocon binding site; other site 655816000478 protein-rRNA interface [nucleotide binding]; other site 655816000479 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 655816000480 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 655816000481 G-X-X-G motif; other site 655816000482 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 655816000483 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 655816000484 23S rRNA interface [nucleotide binding]; other site 655816000485 5S rRNA interface [nucleotide binding]; other site 655816000486 putative antibiotic binding site [chemical binding]; other site 655816000487 L25 interface [polypeptide binding]; other site 655816000488 L27 interface [polypeptide binding]; other site 655816000489 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 655816000490 23S rRNA interface [nucleotide binding]; other site 655816000491 putative translocon interaction site; other site 655816000492 signal recognition particle (SRP54) interaction site; other site 655816000493 L23 interface [polypeptide binding]; other site 655816000494 trigger factor interaction site; other site 655816000495 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 655816000496 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 655816000497 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 655816000498 KOW motif; Region: KOW; cl00354 655816000499 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 655816000500 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 655816000501 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 655816000502 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 655816000503 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 655816000504 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 655816000505 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 655816000506 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 655816000507 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 655816000508 5S rRNA interface [nucleotide binding]; other site 655816000509 L27 interface [polypeptide binding]; other site 655816000510 23S rRNA interface [nucleotide binding]; other site 655816000511 L5 interface [polypeptide binding]; other site 655816000512 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 655816000513 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 655816000514 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 655816000515 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 655816000516 23S rRNA binding site [nucleotide binding]; other site 655816000517 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 655816000518 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 655816000519 SecY translocase; Region: SecY; pfam00344 655816000520 adenylate kinase; Reviewed; Region: adk; PRK00279 655816000521 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 655816000522 AMP-binding site [chemical binding]; other site 655816000523 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 655816000524 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 655816000525 active site 655816000526 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 655816000527 rRNA binding site [nucleotide binding]; other site 655816000528 predicted 30S ribosome binding site; other site 655816000529 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 655816000530 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 655816000531 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 655816000532 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 655816000533 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 655816000534 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 655816000535 alphaNTD homodimer interface [polypeptide binding]; other site 655816000536 alphaNTD - beta interaction site [polypeptide binding]; other site 655816000537 alphaNTD - beta' interaction site [polypeptide binding]; other site 655816000538 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 655816000539 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 655816000540 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 655816000541 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 655816000542 Walker A/P-loop; other site 655816000543 ATP binding site [chemical binding]; other site 655816000544 Q-loop/lid; other site 655816000545 ABC transporter signature motif; other site 655816000546 Walker B; other site 655816000547 D-loop; other site 655816000548 H-loop/switch region; other site 655816000549 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 655816000550 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 655816000551 Walker A/P-loop; other site 655816000552 ATP binding site [chemical binding]; other site 655816000553 Q-loop/lid; other site 655816000554 ABC transporter signature motif; other site 655816000555 Walker B; other site 655816000556 D-loop; other site 655816000557 H-loop/switch region; other site 655816000558 Cobalt transport protein; Region: CbiQ; cl00463 655816000559 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 655816000560 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 655816000561 dimerization interface 3.5A [polypeptide binding]; other site 655816000562 active site 655816000563 L13 leader; ribosomal protein gene, untranslated leader; autoregulatory structure; BSUW23_misc_RNA_4 655816000564 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 655816000565 23S rRNA interface [nucleotide binding]; other site 655816000566 L3 interface [polypeptide binding]; other site 655816000567 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 655816000568 Methyltransferase domain; Region: Methyltransf_31; pfam13847 655816000569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816000570 S-adenosylmethionine binding site [chemical binding]; other site 655816000571 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 655816000572 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 655816000573 active site 655816000574 metal binding site [ion binding]; metal-binding site 655816000575 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 655816000576 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 655816000577 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 655816000578 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 655816000579 NodB motif; other site 655816000580 putative active site [active] 655816000581 putative catalytic site [active] 655816000582 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816000583 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 655816000584 Sulfate transporter family; Region: Sulfate_transp; cl15842 655816000585 Sulfate transporter family; Region: Sulfate_transp; cl15842 655816000586 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 655816000587 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 655816000588 Membrane transport protein; Region: Mem_trans; cl09117 655816000589 Membrane transport protein; Region: Mem_trans; cl09117 655816000590 Putative esterase; Region: Esterase; pfam00756 655816000591 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 655816000592 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 655816000593 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655816000594 dimer interface [polypeptide binding]; other site 655816000595 putative PBP binding regions; other site 655816000596 ABC-ATPase subunit interface; other site 655816000597 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655816000598 ABC-ATPase subunit interface; other site 655816000599 dimer interface [polypeptide binding]; other site 655816000600 putative PBP binding regions; other site 655816000601 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 655816000602 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 655816000603 putative ligand binding residues [chemical binding]; other site 655816000604 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655816000605 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 655816000606 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655816000607 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 655816000608 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 655816000609 intersubunit interface [polypeptide binding]; other site 655816000610 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 655816000611 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 655816000612 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 655816000613 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 655816000614 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 655816000615 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 655816000616 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 655816000617 active site turn [active] 655816000618 phosphorylation site [posttranslational modification] 655816000619 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 655816000620 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 655816000621 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 655816000622 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 655816000623 putative active site [active] 655816000624 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 655816000625 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 655816000626 putative active site [active] 655816000627 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 655816000628 Protein of unknown function (DUF523); Region: DUF523; cl00733 655816000629 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 655816000630 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655816000631 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655816000632 DNA binding residues [nucleotide binding] 655816000633 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 655816000634 Putative zinc-finger; Region: zf-HC2; cl15806 655816000635 TIGR00159 family protein; Region: TIGR00159 655816000636 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 655816000637 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 655816000638 YbbR-like protein; Region: YbbR; pfam07949 655816000639 YbbR-like protein; Region: YbbR; pfam07949 655816000640 YbbR-like protein; Region: YbbR; pfam07949 655816000641 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 655816000642 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 655816000643 active site 655816000644 substrate binding site [chemical binding]; other site 655816000645 metal binding site [ion binding]; metal-binding site 655816000646 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 655816000647 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 655816000648 glutaminase active site [active] 655816000649 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 655816000650 dimer interface [polypeptide binding]; other site 655816000651 active site 655816000652 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 655816000653 dimer interface [polypeptide binding]; other site 655816000654 active site 655816000655 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 655816000656 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 655816000657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 655816000658 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 655816000659 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 655816000660 zinc binding site [ion binding]; other site 655816000661 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 655816000662 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 655816000663 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 655816000664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816000665 active site 655816000666 phosphorylation site [posttranslational modification] 655816000667 intermolecular recognition site; other site 655816000668 dimerization interface [polypeptide binding]; other site 655816000669 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655816000670 DNA binding site [nucleotide binding] 655816000671 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 655816000672 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 655816000673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 655816000674 rhizocticin biosynthetic gene cluster 655816000675 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655816000676 Helix-turn-helix domains; Region: HTH; cl00088 655816000677 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 655816000678 dimerization interface [polypeptide binding]; other site 655816000679 threonine synthase; Validated; Region: PRK06260 655816000680 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 655816000681 homodimer interface [polypeptide binding]; other site 655816000682 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816000683 catalytic residue [active] 655816000684 ATP-grasp domain; Region: ATP-grasp_4; cl03087 655816000685 putative transporter; Provisional; Region: PRK10054 655816000686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816000687 putative substrate translocation pore; other site 655816000688 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 655816000689 PYR/PP interface [polypeptide binding]; other site 655816000690 dimer interface [polypeptide binding]; other site 655816000691 TPP binding site [chemical binding]; other site 655816000692 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 655816000693 sulfopyruvate decarboxylase, beta subunit; Region: sulfopy_beta; TIGR03846 655816000694 TPP-binding site [chemical binding]; other site 655816000695 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 655816000696 active site 655816000697 catalytic residues [active] 655816000698 metal binding site [ion binding]; metal-binding site 655816000699 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 655816000700 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 655816000701 tetramer interface [polypeptide binding]; other site 655816000702 active site 655816000703 Mg2+/Mn2+ binding site [ion binding]; other site 655816000704 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 655816000705 Hpr binding site; other site 655816000706 active site 655816000707 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 655816000708 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 655816000709 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 655816000710 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 655816000711 catalytic residue [active] 655816000712 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 655816000713 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 655816000714 ATP-grasp domain; Region: ATP-grasp_4; cl03087 655816000715 Catalytic domain of Protein Kinases; Region: PKc; cd00180 655816000716 active site 655816000717 ATP binding site [chemical binding]; other site 655816000718 substrate binding site [chemical binding]; other site 655816000719 activation loop (A-loop); other site 655816000720 putative transport protein YifK; Provisional; Region: PRK10746 655816000721 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 655816000722 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 655816000723 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 655816000724 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 655816000725 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 655816000726 PhoU domain; Region: PhoU; pfam01895 655816000727 PhoU domain; Region: PhoU; pfam01895 655816000728 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 655816000729 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 655816000730 active site 655816000731 catalytic site [active] 655816000732 metal binding site [ion binding]; metal-binding site 655816000733 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 655816000734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816000735 putative substrate translocation pore; other site 655816000736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816000737 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 655816000738 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816000739 Helix-turn-helix domains; Region: HTH; cl00088 655816000740 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 655816000741 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816000742 Coenzyme A binding pocket [chemical binding]; other site 655816000743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816000744 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816000745 putative substrate translocation pore; other site 655816000746 EamA-like transporter family; Region: EamA; cl01037 655816000747 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 655816000748 EamA-like transporter family; Region: EamA; cl01037 655816000749 Cupin domain; Region: Cupin_2; cl09118 655816000750 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655816000751 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 655816000752 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655816000753 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 655816000754 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 655816000755 ATP-grasp domain; Region: ATP-grasp_4; cl03087 655816000756 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 655816000757 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 655816000758 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 655816000759 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 655816000760 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 655816000761 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 655816000762 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 655816000763 Erythromycin esterase; Region: Erythro_esteras; pfam05139 655816000764 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 655816000765 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 655816000766 active site residue [active] 655816000767 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 655816000768 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 655816000769 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 655816000770 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 655816000771 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 655816000772 active site turn [active] 655816000773 phosphorylation site [posttranslational modification] 655816000774 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 655816000775 HPr interaction site; other site 655816000776 glycerol kinase (GK) interaction site [polypeptide binding]; other site 655816000777 active site 655816000778 phosphorylation site [posttranslational modification] 655816000779 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 655816000780 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 655816000781 active site 655816000782 trimer interface [polypeptide binding]; other site 655816000783 allosteric site; other site 655816000784 active site lid [active] 655816000785 hexamer (dimer of trimers) interface [polypeptide binding]; other site 655816000786 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 655816000787 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816000788 DNA-binding site [nucleotide binding]; DNA binding site 655816000789 UTRA domain; Region: UTRA; cl01230 655816000790 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 655816000791 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 655816000792 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 655816000793 homodimer interface [polypeptide binding]; other site 655816000794 substrate-cofactor binding pocket; other site 655816000795 catalytic residue [active] 655816000796 S-methylmethionine transporter; Provisional; Region: PRK11387 655816000797 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 655816000798 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 655816000799 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 655816000800 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 655816000801 Glutaminase; Region: Glutaminase; cl00907 655816000802 Chorismate mutase type II; Region: CM_2; cl00693 655816000803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816000804 ATP binding site [chemical binding]; other site 655816000805 Mg2+ binding site [ion binding]; other site 655816000806 G-X-G motif; other site 655816000807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816000808 Response regulator receiver domain; Region: Response_reg; pfam00072 655816000809 active site 655816000810 phosphorylation site [posttranslational modification] 655816000811 intermolecular recognition site; other site 655816000812 dimerization interface [polypeptide binding]; other site 655816000813 YcbB domain; Region: YcbB; pfam08664 655816000814 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 655816000815 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 655816000816 putative active site [active] 655816000817 catalytic residue [active] 655816000818 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 655816000819 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 655816000820 NAD(P) binding site [chemical binding]; other site 655816000821 catalytic residues [active] 655816000822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816000823 D-galactonate transporter; Region: 2A0114; TIGR00893 655816000824 putative substrate translocation pore; other site 655816000825 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 655816000826 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 655816000827 active site 655816000828 tetramer interface [polypeptide binding]; other site 655816000829 Transcriptional regulators [Transcription]; Region: FadR; COG2186 655816000830 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816000831 DNA-binding site [nucleotide binding]; DNA binding site 655816000832 FCD domain; Region: FCD; cl11656 655816000833 galactarate dehydratase; Region: galactar-dH20; TIGR03248 655816000834 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 655816000835 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 655816000836 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: MPH2'; cd05152 655816000837 putative active site [active] 655816000838 putative substrate binding site [chemical binding]; other site 655816000839 ATP binding site [chemical binding]; other site 655816000840 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 655816000841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816000842 active site 655816000843 phosphorylation site [posttranslational modification] 655816000844 intermolecular recognition site; other site 655816000845 dimerization interface [polypeptide binding]; other site 655816000846 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655816000847 DNA binding site [nucleotide binding] 655816000848 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655816000849 dimer interface [polypeptide binding]; other site 655816000850 phosphorylation site [posttranslational modification] 655816000851 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816000852 ATP binding site [chemical binding]; other site 655816000853 Mg2+ binding site [ion binding]; other site 655816000854 G-X-G motif; other site 655816000855 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 655816000856 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 655816000857 Walker A/P-loop; other site 655816000858 ATP binding site [chemical binding]; other site 655816000859 Q-loop/lid; other site 655816000860 ABC transporter signature motif; other site 655816000861 Walker B; other site 655816000862 D-loop; other site 655816000863 H-loop/switch region; other site 655816000864 ABC-2 type transporter; Region: ABC2_membrane; cl11417 655816000865 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 655816000866 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 655816000867 reactive center loop; other site 655816000868 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 655816000869 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 655816000870 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 655816000871 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 655816000872 putative active site [active] 655816000873 putative metal binding site [ion binding]; other site 655816000874 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 655816000875 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 655816000876 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 655816000877 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 655816000878 putative substrate binding pocket [chemical binding]; other site 655816000879 AC domain interface; other site 655816000880 catalytic triad [active] 655816000881 AB domain interface; other site 655816000882 interchain disulfide; other site 655816000883 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 655816000884 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 655816000885 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 655816000886 catalytic residue [active] 655816000887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816000888 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 655816000889 putative substrate translocation pore; other site 655816000890 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655816000891 Helix-turn-helix domains; Region: HTH; cl00088 655816000892 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 655816000893 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 655816000894 RDD family; Region: RDD; cl00746 655816000895 Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318 655816000896 helix-turn-helix, Psq domain; Region: HTH_psq; pfam05225 655816000897 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 655816000898 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 655816000899 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 655816000900 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 655816000901 active site 655816000902 catalytic tetrad [active] 655816000903 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 655816000904 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 655816000905 Helix-turn-helix domains; Region: HTH; cl00088 655816000906 putative transposase OrfB; Reviewed; Region: PHA02517 655816000907 HTH-like domain; Region: HTH_21; pfam13276 655816000908 Integrase core domain; Region: rve; cl01316 655816000909 Integrase core domain; Region: rve_3; cl15866 655816000910 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 655816000911 glucose-1-dehydrogenase; Provisional; Region: PRK08936 655816000912 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 655816000913 NAD binding site [chemical binding]; other site 655816000914 homodimer interface [polypeptide binding]; other site 655816000915 active site 655816000916 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 655816000917 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 655816000918 Ca binding site [ion binding]; other site 655816000919 active site 655816000920 catalytic site [active] 655816000921 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 655816000922 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 655816000923 metal binding site [ion binding]; metal-binding site 655816000924 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 655816000925 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 655816000926 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655816000927 ABC-ATPase subunit interface; other site 655816000928 dimer interface [polypeptide binding]; other site 655816000929 putative PBP binding regions; other site 655816000930 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 655816000931 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 655816000932 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 655816000933 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 655816000934 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 655816000935 putative metal binding site [ion binding]; other site 655816000936 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 655816000937 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 655816000938 putative metal binding site [ion binding]; other site 655816000939 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 655816000940 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 655816000941 putative metal binding site [ion binding]; other site 655816000942 Integral membrane protein TerC family; Region: TerC; cl10468 655816000943 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 655816000944 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 655816000945 benzoate transport; Region: 2A0115; TIGR00895 655816000946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816000947 putative substrate translocation pore; other site 655816000948 Helix-turn-helix domains; Region: HTH; cl00088 655816000949 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 655816000950 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 655816000951 Walker A/P-loop; other site 655816000952 ATP binding site [chemical binding]; other site 655816000953 Q-loop/lid; other site 655816000954 ABC transporter signature motif; other site 655816000955 Walker B; other site 655816000956 D-loop; other site 655816000957 H-loop/switch region; other site 655816000958 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 655816000959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816000960 dimer interface [polypeptide binding]; other site 655816000961 conserved gate region; other site 655816000962 putative PBP binding loops; other site 655816000963 ABC-ATPase subunit interface; other site 655816000964 NMT1-like family; Region: NMT1_2; cl15260 655816000965 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 655816000966 amidohydrolase; Region: amidohydrolases; TIGR01891 655816000967 metal binding site [ion binding]; metal-binding site 655816000968 putative dimer interface [polypeptide binding]; other site 655816000969 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 655816000970 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 655816000971 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315 655816000972 active site 655816000973 Ca binding site [ion binding]; other site 655816000974 catalytic site [active] 655816000975 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 655816000976 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 655816000977 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 655816000978 tetramer (dimer of dimers) interface [polypeptide binding]; other site 655816000979 NAD binding site [chemical binding]; other site 655816000980 dimer interface [polypeptide binding]; other site 655816000981 substrate binding site [chemical binding]; other site 655816000982 glycolate transporter; Provisional; Region: PRK09695 655816000983 L-lactate permease; Region: Lactate_perm; cl00701 655816000984 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816000985 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816000986 putative substrate translocation pore; other site 655816000987 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816000988 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816000989 Helix-turn-helix domains; Region: HTH; cl00088 655816000990 LysE type translocator; Region: LysE; cl00565 655816000991 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 655816000992 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 655816000993 Spore germination protein; Region: Spore_permease; cl15802 655816000994 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 655816000995 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 655816000996 NAD+ synthetase; Region: nadE; TIGR00552 655816000997 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 655816000998 homodimer interface [polypeptide binding]; other site 655816000999 NAD binding pocket [chemical binding]; other site 655816001000 ATP binding pocket [chemical binding]; other site 655816001001 Mg binding site [ion binding]; other site 655816001002 active-site loop [active] 655816001003 AAA domain; Region: AAA_18; pfam13238 655816001004 shikimate kinase; Reviewed; Region: aroK; PRK00131 655816001005 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 655816001006 ADP binding site [chemical binding]; other site 655816001007 magnesium binding site [ion binding]; other site 655816001008 putative shikimate binding site; other site 655816001009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816001010 S-adenosylmethionine binding site [chemical binding]; other site 655816001011 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655816001012 Helix-turn-helix domains; Region: HTH; cl00088 655816001013 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 655816001014 dimerization interface [polypeptide binding]; other site 655816001015 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 655816001016 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 655816001017 Proline dehydrogenase; Region: Pro_dh; cl03282 655816001018 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 655816001019 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 655816001020 Glutamate binding site [chemical binding]; other site 655816001021 homodimer interface [polypeptide binding]; other site 655816001022 NAD binding site [chemical binding]; other site 655816001023 catalytic residues [active] 655816001024 Sodium:solute symporter family; Region: SSF; cl00456 655816001025 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 655816001026 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 655816001027 Helix-turn-helix domains; Region: HTH; cl00088 655816001028 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 655816001029 Predicted permeases [General function prediction only]; Region: COG0701 655816001030 Predicted permease; Region: DUF318; pfam03773 655816001031 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 655816001032 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 655816001033 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 655816001034 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655816001035 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 655816001036 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 655816001037 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 655816001038 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 655816001039 active site 655816001040 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 655816001041 [2Fe-2S] cluster binding site [ion binding]; other site 655816001042 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 655816001043 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655816001044 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 655816001045 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 655816001046 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 655816001047 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 655816001048 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 655816001049 [4Fe-4S] binding site [ion binding]; other site 655816001050 molybdopterin cofactor binding site; other site 655816001051 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 655816001052 molybdopterin cofactor binding site; other site 655816001053 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 655816001054 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655816001055 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 655816001056 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 655816001057 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 655816001058 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 655816001059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816001060 putative substrate translocation pore; other site 655816001061 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 655816001062 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 655816001063 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 655816001064 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816001065 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655816001066 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 655816001067 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816001068 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 655816001069 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 655816001070 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816001071 dimer interface [polypeptide binding]; other site 655816001072 conserved gate region; other site 655816001073 putative PBP binding loops; other site 655816001074 ABC-ATPase subunit interface; other site 655816001075 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 655816001076 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 655816001077 substrate binding pocket [chemical binding]; other site 655816001078 membrane-bound complex binding site; other site 655816001079 hinge residues; other site 655816001080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816001081 RDD family; Region: RDD; cl00746 655816001082 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 655816001083 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816001084 Helix-turn-helix domains; Region: HTH; cl00088 655816001085 hypothetical protein; Provisional; Region: PRK09272 655816001086 Predicted ATPase [General function prediction only]; Region: COG3910 655816001087 ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The...; Region: ABC_ATPase; cd00267 655816001088 Walker A/P-loop; other site 655816001089 ATP binding site [chemical binding]; other site 655816001090 Q-loop/lid; other site 655816001091 ABC transporter signature motif; other site 655816001092 Walker B; other site 655816001093 D-loop; other site 655816001094 H-loop/switch region; other site 655816001095 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 655816001096 Competence protein J (ComJ); Region: ComJ; pfam11033 655816001097 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 655816001098 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 655816001099 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 655816001100 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 655816001101 dimer interface [polypeptide binding]; other site 655816001102 putative CheW interface [polypeptide binding]; other site 655816001103 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 655816001104 tetramer interface [polypeptide binding]; other site 655816001105 Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane]; Region: GutQ; COG0794 655816001106 active site 655816001107 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 655816001108 active site 655816001109 dimer interface [polypeptide binding]; other site 655816001110 magnesium binding site [ion binding]; other site 655816001111 Helix-turn-helix domains; Region: HTH; cl00088 655816001112 peptide synthase; Provisional; Region: PRK12316 655816001113 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 655816001114 AMP-binding enzyme; Region: AMP-binding; cl15778 655816001115 AMP-binding enzyme; Region: AMP-binding; cl15778 655816001116 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816001117 peptide synthase; Provisional; Region: PRK12316 655816001118 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 655816001119 AMP-binding enzyme; Region: AMP-binding; cl15778 655816001120 AMP-binding enzyme; Region: AMP-binding; cl15778 655816001121 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816001122 peptide synthase; Provisional; Region: PRK12316 655816001123 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 655816001124 AMP-binding enzyme; Region: AMP-binding; cl15778 655816001125 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816001126 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 655816001127 peptide synthase; Provisional; Region: PRK12467 655816001128 AMP-binding enzyme; Region: AMP-binding; cl15778 655816001129 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816001130 peptide synthase; Provisional; Region: PRK12467 655816001131 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 655816001132 AMP-binding enzyme; Region: AMP-binding; cl15778 655816001133 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816001134 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 655816001135 AMP-binding enzyme; Region: AMP-binding; cl15778 655816001136 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816001137 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 655816001138 peptide synthase; Provisional; Region: PRK12467 655816001139 AMP-binding enzyme; Region: AMP-binding; cl15778 655816001140 AMP-binding enzyme; Region: AMP-binding; cl15778 655816001141 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816001142 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 655816001143 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 655816001144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816001145 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816001146 putative substrate translocation pore; other site 655816001147 YcxB-like protein; Region: YcxB; pfam14317 655816001148 EamA-like transporter family; Region: EamA; cl01037 655816001149 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 655816001150 EamA-like transporter family; Region: EamA; cl01037 655816001151 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 655816001152 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816001153 DNA-binding site [nucleotide binding]; DNA binding site 655816001154 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655816001155 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816001156 homodimer interface [polypeptide binding]; other site 655816001157 catalytic residue [active] 655816001158 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 655816001159 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 655816001160 Predicted membrane protein [Function unknown]; Region: COG2364 655816001161 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 655816001162 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 655816001163 Walker A/P-loop; other site 655816001164 ATP binding site [chemical binding]; other site 655816001165 Q-loop/lid; other site 655816001166 ABC transporter signature motif; other site 655816001167 Walker B; other site 655816001168 D-loop; other site 655816001169 H-loop/switch region; other site 655816001170 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 655816001171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816001172 dimer interface [polypeptide binding]; other site 655816001173 conserved gate region; other site 655816001174 putative PBP binding loops; other site 655816001175 ABC-ATPase subunit interface; other site 655816001176 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 655816001177 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 655816001178 substrate binding pocket [chemical binding]; other site 655816001179 membrane-bound complex binding site; other site 655816001180 hinge residues; other site 655816001181 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655816001182 Helix-turn-helix domains; Region: HTH; cl00088 655816001183 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 655816001184 dimerization interface [polypeptide binding]; other site 655816001185 polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases; Region: ubiX_pad; TIGR00421 655816001186 Flavoprotein; Region: Flavoprotein; cl08021 655816001187 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 655816001188 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 655816001189 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 655816001190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816001191 putative substrate translocation pore; other site 655816001192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 655816001193 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 655816001194 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 655816001195 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 655816001196 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 655816001197 Spore germination protein; Region: Spore_permease; cl15802 655816001198 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 655816001199 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 655816001200 Walker A/P-loop; other site 655816001201 ATP binding site [chemical binding]; other site 655816001202 Q-loop/lid; other site 655816001203 ABC transporter signature motif; other site 655816001204 Walker B; other site 655816001205 D-loop; other site 655816001206 H-loop/switch region; other site 655816001207 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 655816001208 FtsX-like permease family; Region: FtsX; cl15850 655816001209 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 655816001210 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816001211 active site 655816001212 phosphorylation site [posttranslational modification] 655816001213 intermolecular recognition site; other site 655816001214 dimerization interface [polypeptide binding]; other site 655816001215 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655816001216 DNA binding site [nucleotide binding] 655816001217 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 655816001218 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 655816001219 dimerization interface [polypeptide binding]; other site 655816001220 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655816001221 dimer interface [polypeptide binding]; other site 655816001222 phosphorylation site [posttranslational modification] 655816001223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816001224 ATP binding site [chemical binding]; other site 655816001225 Mg2+ binding site [ion binding]; other site 655816001226 G-X-G motif; other site 655816001227 Tetratricopeptide repeat; Region: TPR_12; pfam13424 655816001228 Tetratricopeptide repeat; Region: TPR_12; pfam13424 655816001229 Tetratricopeptide repeat; Region: TPR_12; pfam13424 655816001230 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 655816001231 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 655816001232 aspartate kinase; Reviewed; Region: PRK09034 655816001233 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 655816001234 putative catalytic residues [active] 655816001235 putative nucleotide binding site [chemical binding]; other site 655816001236 putative aspartate binding site [chemical binding]; other site 655816001237 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 655816001238 allosteric regulatory residue; other site 655816001239 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 655816001240 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 655816001241 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655816001242 ABC-ATPase subunit interface; other site 655816001243 dimer interface [polypeptide binding]; other site 655816001244 putative PBP binding regions; other site 655816001245 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655816001246 ABC-ATPase subunit interface; other site 655816001247 dimer interface [polypeptide binding]; other site 655816001248 putative PBP binding regions; other site 655816001249 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 655816001250 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 655816001251 Walker A/P-loop; other site 655816001252 ATP binding site [chemical binding]; other site 655816001253 Q-loop/lid; other site 655816001254 ABC transporter signature motif; other site 655816001255 Walker B; other site 655816001256 D-loop; other site 655816001257 H-loop/switch region; other site 655816001258 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 655816001259 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 655816001260 putative ligand binding residues [chemical binding]; other site 655816001261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816001262 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816001263 putative substrate translocation pore; other site 655816001264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816001265 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655816001266 Helix-turn-helix domains; Region: HTH; cl00088 655816001267 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 655816001268 dimer interface [polypeptide binding]; other site 655816001269 FMN binding site [chemical binding]; other site 655816001270 NADPH bind site [chemical binding]; other site 655816001271 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 655816001272 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 655816001273 dimerization interface [polypeptide binding]; other site 655816001274 putative DNA binding site [nucleotide binding]; other site 655816001275 putative Zn2+ binding site [ion binding]; other site 655816001276 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 655816001277 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816001278 DNA-binding site [nucleotide binding]; DNA binding site 655816001279 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655816001280 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816001281 homodimer interface [polypeptide binding]; other site 655816001282 catalytic residue [active] 655816001283 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 655816001284 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 655816001285 inhibitor-cofactor binding pocket; inhibition site 655816001286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816001287 catalytic residue [active] 655816001288 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 655816001289 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 655816001290 tetramerization interface [polypeptide binding]; other site 655816001291 NAD(P) binding site [chemical binding]; other site 655816001292 catalytic residues [active] 655816001293 Sugar transport protein; Region: Sugar_transport; pfam06800 655816001294 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 655816001295 glucose-1-dehydrogenase; Provisional; Region: PRK08936 655816001296 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 655816001297 NAD binding site [chemical binding]; other site 655816001298 homodimer interface [polypeptide binding]; other site 655816001299 active site 655816001300 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 655816001301 Bacterial Ig-like domain; Region: Big_5; cl01012 655816001302 Copper resistance protein D; Region: CopD; cl00563 655816001303 FixH; Region: FixH; cl01254 655816001304 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 655816001305 Helix-turn-helix domains; Region: HTH; cl00088 655816001306 NosL; Region: NosL; cl01769 655816001307 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 655816001308 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 655816001309 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 655816001310 active site 655816001311 P-loop; other site 655816001312 phosphorylation site [posttranslational modification] 655816001313 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 655816001314 active site 655816001315 phosphorylation site [posttranslational modification] 655816001316 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 655816001317 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 655816001318 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 655816001319 tartrate dehydrogenase; Provisional; Region: PRK08194 655816001320 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 655816001321 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 655816001322 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 655816001323 Catalytic site [active] 655816001324 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 655816001325 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 655816001326 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816001327 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 655816001328 active site 655816001329 motif I; other site 655816001330 motif II; other site 655816001331 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816001332 LamB/YcsF family; Region: LamB_YcsF; cl00664 655816001333 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 655816001334 Protein of unknown function (DUF1445); Region: DUF1445; cl01790 655816001335 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 655816001336 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 655816001337 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 655816001338 Transcriptional regulator [Transcription]; Region: IclR; COG1414 655816001339 Helix-turn-helix domains; Region: HTH; cl00088 655816001340 Bacterial transcriptional regulator; Region: IclR; pfam01614 655816001341 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 655816001342 active site 655816001343 catalytic triad [active] 655816001344 oxyanion hole [active] 655816001345 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 655816001346 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 655816001347 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 655816001348 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 655816001349 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 655816001350 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 655816001351 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 655816001352 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 655816001353 active site 655816001354 catalytic tetrad [active] 655816001355 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 655816001356 Helix-turn-helix domains; Region: HTH; cl00088 655816001357 Helix-turn-helix domains; Region: HTH; cl00088 655816001358 PRD domain; Region: PRD; cl15445 655816001359 PRD domain; Region: PRD; cl15445 655816001360 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 655816001361 P-loop; other site 655816001362 active site 655816001363 phosphorylation site [posttranslational modification] 655816001364 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 655816001365 AMP-binding enzyme; Region: AMP-binding; cl15778 655816001366 AMP-binding enzyme; Region: AMP-binding; cl15778 655816001367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816001368 S-adenosylmethionine binding site [chemical binding]; other site 655816001369 short chain dehydrogenase; Provisional; Region: PRK06701 655816001370 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 655816001371 NAD binding site [chemical binding]; other site 655816001372 metal binding site [ion binding]; metal-binding site 655816001373 active site 655816001374 Cupin domain; Region: Cupin_2; cl09118 655816001375 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 655816001376 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 655816001377 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 655816001378 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 655816001379 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 655816001380 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 655816001381 Helix-turn-helix domains; Region: HTH; cl00088 655816001382 DNA topoisomerase III; Provisional; Region: PRK07726 655816001383 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 655816001384 active site 655816001385 putative interdomain interaction site [polypeptide binding]; other site 655816001386 putative metal-binding site [ion binding]; other site 655816001387 putative nucleotide binding site [chemical binding]; other site 655816001388 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 655816001389 domain I; other site 655816001390 DNA binding groove [nucleotide binding] 655816001391 phosphate binding site [ion binding]; other site 655816001392 domain II; other site 655816001393 domain III; other site 655816001394 nucleotide binding site [chemical binding]; other site 655816001395 catalytic site [active] 655816001396 domain IV; other site 655816001397 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 655816001398 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 655816001399 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 655816001400 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001 655816001401 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 655816001402 metal binding site [ion binding]; metal-binding site 655816001403 active site 655816001404 I-site; other site 655816001405 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 655816001406 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 655816001407 NodB motif; other site 655816001408 putative active site [active] 655816001409 putative catalytic site [active] 655816001410 putative Zn binding site [ion binding]; other site 655816001411 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 655816001412 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 655816001413 DXD motif; other site 655816001414 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 655816001415 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 655816001416 ydaO riboswitch leader; may be triggered during osmotic shock, leading to expression of ydaO; the natural ligand has not been determined; BSUW23_misc_RNA_7 655816001417 Amino acid permease; Region: AA_permease_2; pfam13520 655816001418 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 655816001419 nudix motif; other site 655816001420 pyruvate oxidase; Provisional; Region: PRK08611 655816001421 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 655816001422 PYR/PP interface [polypeptide binding]; other site 655816001423 tetramer interface [polypeptide binding]; other site 655816001424 dimer interface [polypeptide binding]; other site 655816001425 TPP binding site [chemical binding]; other site 655816001426 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 655816001427 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 655816001428 TPP-binding site [chemical binding]; other site 655816001429 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 655816001430 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 655816001431 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 655816001432 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 655816001433 EcsC protein family; Region: EcsC; pfam12787 655816001434 General stress protein [General function prediction only]; Region: GsiB; COG3729 655816001435 Cupin domain; Region: Cupin_2; cl09118 655816001436 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 655816001437 dimanganese center [ion binding]; other site 655816001438 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 655816001439 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 655816001440 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 655816001441 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 655816001442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816001443 ATP binding site [chemical binding]; other site 655816001444 Mg2+ binding site [ion binding]; other site 655816001445 G-X-G motif; other site 655816001446 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 655816001447 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816001448 active site 655816001449 phosphorylation site [posttranslational modification] 655816001450 intermolecular recognition site; other site 655816001451 dimerization interface [polypeptide binding]; other site 655816001452 Helix-turn-helix domains; Region: HTH; cl00088 655816001453 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 655816001454 Domain of unknown function DUF20; Region: UPF0118; pfam01594 655816001455 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 655816001456 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 655816001457 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 655816001458 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 655816001459 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816001460 Walker A/P-loop; other site 655816001461 ATP binding site [chemical binding]; other site 655816001462 Q-loop/lid; other site 655816001463 ABC transporter signature motif; other site 655816001464 Walker B; other site 655816001465 D-loop; other site 655816001466 H-loop/switch region; other site 655816001467 ABC-2 type transporter; Region: ABC2_membrane; cl11417 655816001468 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 655816001469 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 655816001470 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 655816001471 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 655816001472 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 655816001473 Cation efflux family; Region: Cation_efflux; cl00316 655816001474 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 655816001475 catalytic residues [active] 655816001476 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 655816001477 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 655816001478 ATP-grasp domain; Region: ATP-grasp_4; cl03087 655816001479 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 655816001480 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 655816001481 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 655816001482 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 655816001483 helicase 45; Provisional; Region: PTZ00424 655816001484 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 655816001485 ATP binding site [chemical binding]; other site 655816001486 Mg++ binding site [ion binding]; other site 655816001487 motif III; other site 655816001488 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655816001489 nucleotide binding region [chemical binding]; other site 655816001490 ATP-binding site [chemical binding]; other site 655816001491 Bacterial PH domain; Region: DUF304; cl01348 655816001492 Predicted membrane protein [Function unknown]; Region: COG3428 655816001493 Bacterial PH domain; Region: DUF304; cl01348 655816001494 Bacterial PH domain; Region: DUF304; cl01348 655816001495 Bacterial PH domain; Region: DUF304; cl01348 655816001496 Rhomboid family; Region: Rhomboid; cl11446 655816001497 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 655816001498 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 655816001499 alanine racemase; Region: alr; TIGR00492 655816001500 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 655816001501 active site 655816001502 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 655816001503 dimer interface [polypeptide binding]; other site 655816001504 substrate binding site [chemical binding]; other site 655816001505 catalytic residues [active] 655816001506 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 655816001507 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 655816001508 PemK-like protein; Region: PemK; cl00995 655816001509 Rsbr N terminal; Region: Rsbr_N; pfam08678 655816001510 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 655816001511 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 655816001512 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 655816001513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816001514 ATP binding site [chemical binding]; other site 655816001515 Mg2+ binding site [ion binding]; other site 655816001516 G-X-G motif; other site 655816001517 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 655816001518 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 655816001519 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 655816001520 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 655816001521 anti sigma factor interaction site; other site 655816001522 regulatory phosphorylation site [posttranslational modification]; other site 655816001523 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 655816001524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816001525 ATP binding site [chemical binding]; other site 655816001526 Mg2+ binding site [ion binding]; other site 655816001527 G-X-G motif; other site 655816001528 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 655816001529 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655816001530 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 655816001531 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655816001532 DNA binding residues [nucleotide binding] 655816001533 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 655816001534 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 655816001535 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 655816001536 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 655816001537 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 655816001538 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 655816001539 RNA binding site [nucleotide binding]; other site 655816001540 SprT homologues; Region: SprT; cl01182 655816001541 hypothetical protein; Provisional; Region: PRK04351 655816001542 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 655816001543 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 655816001544 DNA binding residues [nucleotide binding] 655816001545 putative dimer interface [polypeptide binding]; other site 655816001546 short chain dehydrogenase; Provisional; Region: PRK06180 655816001547 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 655816001548 NADP binding site [chemical binding]; other site 655816001549 active site 655816001550 steroid binding site; other site 655816001551 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 655816001552 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 655816001553 active site 655816001554 catalytic tetrad [active] 655816001555 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 655816001556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816001557 NAD(P) binding site [chemical binding]; other site 655816001558 active site 655816001559 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 655816001560 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 655816001561 NADP binding site [chemical binding]; other site 655816001562 substrate binding site [chemical binding]; other site 655816001563 active site 655816001564 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 655816001565 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 655816001566 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816001567 NAD(P) binding site [chemical binding]; other site 655816001568 active site 655816001569 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 655816001570 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 655816001571 putative di-iron ligands [ion binding]; other site 655816001572 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 655816001573 DNA-binding site [nucleotide binding]; DNA binding site 655816001574 RNA-binding motif; other site 655816001575 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 655816001576 EamA-like transporter family; Region: EamA; cl01037 655816001577 EamA-like transporter family; Region: EamA; cl01037 655816001578 Predicted transcriptional regulator [Transcription]; Region: COG1395 655816001579 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655816001580 non-specific DNA binding site [nucleotide binding]; other site 655816001581 salt bridge; other site 655816001582 sequence-specific DNA binding site [nucleotide binding]; other site 655816001583 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 655816001584 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 655816001585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 655816001586 Protein of unknown function (DUF419); Region: DUF419; cl15265 655816001587 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 655816001588 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 655816001589 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 655816001590 Helix-turn-helix domains; Region: HTH; cl00088 655816001591 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 655816001592 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816001593 DNA-binding site [nucleotide binding]; DNA binding site 655816001594 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655816001595 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816001596 homodimer interface [polypeptide binding]; other site 655816001597 catalytic residue [active] 655816001598 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 655816001599 putative active site [active] 655816001600 putative catalytic site [active] 655816001601 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 655816001602 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 655816001603 Helix-turn-helix domains; Region: HTH; cl00088 655816001604 Uncharacterized conserved protein [Function unknown]; Region: COG1284 655816001605 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 655816001606 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 655816001607 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 655816001608 Helix-turn-helix domains; Region: HTH; cl00088 655816001609 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 655816001610 dimerization interface [polypeptide binding]; other site 655816001611 putative DNA binding site [nucleotide binding]; other site 655816001612 putative Zn2+ binding site [ion binding]; other site 655816001613 arsenical pump membrane protein; Provisional; Region: PRK15445 655816001614 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 655816001615 transmembrane helices; other site 655816001616 Low molecular weight phosphatase family; Region: LMWPc; cd00115 655816001617 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 655816001618 active site 655816001619 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 655816001620 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 655816001621 EamA-like transporter family; Region: EamA; cl01037 655816001622 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 655816001623 EamA-like transporter family; Region: EamA; cl01037 655816001624 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 655816001625 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816001626 DNA-binding site [nucleotide binding]; DNA binding site 655816001627 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655816001628 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816001629 homodimer interface [polypeptide binding]; other site 655816001630 catalytic residue [active] 655816001631 Flavin Reductases; Region: FlaRed; cl00801 655816001632 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 655816001633 putative Zn2+ binding site [ion binding]; other site 655816001634 putative DNA binding site [nucleotide binding]; other site 655816001635 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 655816001636 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 655816001637 Histidine kinase; Region: HisKA_3; pfam07730 655816001638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816001639 ATP binding site [chemical binding]; other site 655816001640 Mg2+ binding site [ion binding]; other site 655816001641 G-X-G motif; other site 655816001642 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 655816001643 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816001644 active site 655816001645 phosphorylation site [posttranslational modification] 655816001646 intermolecular recognition site; other site 655816001647 dimerization interface [polypeptide binding]; other site 655816001648 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655816001649 DNA binding residues [nucleotide binding] 655816001650 dimerization interface [polypeptide binding]; other site 655816001651 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 655816001652 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 655816001653 AzlC protein; Region: AzlC; cl00570 655816001654 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 655816001655 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 655816001656 Protein of unknown function (DUF554); Region: DUF554; cl00784 655816001657 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 655816001658 DNA binding residues [nucleotide binding] 655816001659 drug binding residues [chemical binding]; other site 655816001660 dimer interface [polypeptide binding]; other site 655816001661 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 655816001662 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 655816001663 Cation efflux family; Region: Cation_efflux; cl00316 655816001664 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 655816001665 dimer interface [polypeptide binding]; other site 655816001666 FMN binding site [chemical binding]; other site 655816001667 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 655816001668 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 655816001669 Zn binding site [ion binding]; other site 655816001670 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 655816001671 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 655816001672 Zn binding site [ion binding]; other site 655816001673 DoxX; Region: DoxX; cl00976 655816001674 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 655816001675 catalytic residues [active] 655816001676 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 655816001677 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816001678 DNA-binding site [nucleotide binding]; DNA binding site 655816001679 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655816001680 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816001681 homodimer interface [polypeptide binding]; other site 655816001682 catalytic residue [active] 655816001683 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 655816001684 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816001685 O-methyltransferase; Region: Methyltransf_3; pfam01596 655816001686 Protein of unknown function (DUF421); Region: DUF421; cl00990 655816001687 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 655816001688 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 655816001689 putative dimer interface [polypeptide binding]; other site 655816001690 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 655816001691 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 655816001692 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655816001693 Helix-turn-helix domains; Region: HTH; cl00088 655816001694 DoxX; Region: DoxX; cl00976 655816001695 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 655816001696 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816001697 Coenzyme A binding pocket [chemical binding]; other site 655816001698 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 655816001699 nucleotide binding site/active site [active] 655816001700 HIT family signature motif; other site 655816001701 catalytic residue [active] 655816001702 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 655816001703 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816001704 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 655816001705 Transcriptional regulators [Transcription]; Region: PurR; COG1609 655816001706 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655816001707 DNA binding site [nucleotide binding] 655816001708 domain linker motif; other site 655816001709 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 655816001710 dimerization interface [polypeptide binding]; other site 655816001711 ligand binding site [chemical binding]; other site 655816001712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816001713 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 655816001714 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 655816001715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816001716 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816001717 putative substrate translocation pore; other site 655816001718 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655816001719 Helix-turn-helix domains; Region: HTH; cl00088 655816001720 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 655816001721 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 655816001722 ABC transporter; Region: ABC_tran_2; pfam12848 655816001723 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 655816001724 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 655816001725 Spore germination protein; Region: Spore_permease; cl15802 655816001726 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 655816001727 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816001728 Helix-turn-helix domains; Region: HTH; cl00088 655816001729 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 655816001730 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 655816001731 dimer interface [polypeptide binding]; other site 655816001732 FMN binding site [chemical binding]; other site 655816001733 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816001734 Helix-turn-helix domains; Region: HTH; cl00088 655816001735 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 655816001736 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655816001737 non-specific DNA binding site [nucleotide binding]; other site 655816001738 salt bridge; other site 655816001739 sequence-specific DNA binding site [nucleotide binding]; other site 655816001740 Cupin domain; Region: Cupin_2; cl09118 655816001741 AzlC protein; Region: AzlC; cl00570 655816001742 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 655816001743 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 655816001744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816001745 putative substrate translocation pore; other site 655816001746 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 655816001747 Transcriptional regulators [Transcription]; Region: GntR; COG1802 655816001748 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816001749 DNA-binding site [nucleotide binding]; DNA binding site 655816001750 FCD domain; Region: FCD; cl11656 655816001751 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 655816001752 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 655816001753 putative peptidoglycan binding site; other site 655816001754 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 655816001755 putative peptidoglycan binding site; other site 655816001756 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 655816001757 active site 655816001758 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 655816001759 homodimer interface [polypeptide binding]; other site 655816001760 glycosyltransferase, MGT family; Region: MGT; TIGR01426 655816001761 active site 655816001762 TDP-binding site; other site 655816001763 acceptor substrate-binding pocket; other site 655816001764 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 655816001765 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 655816001766 dimer interface [polypeptide binding]; other site 655816001767 Alkaline phosphatase homologues; Region: alkPPc; smart00098 655816001768 active site 655816001769 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816001770 Coenzyme A binding pocket [chemical binding]; other site 655816001771 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 655816001772 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 655816001773 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 655816001774 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 655816001775 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 655816001776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816001777 putative substrate translocation pore; other site 655816001778 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 655816001779 active site 655816001780 P-loop; other site 655816001781 phosphorylation site [posttranslational modification] 655816001782 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 655816001783 active site 655816001784 methionine cluster; other site 655816001785 phosphorylation site [posttranslational modification] 655816001786 metal binding site [ion binding]; metal-binding site 655816001787 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 655816001788 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 655816001789 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 655816001790 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 655816001791 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816001792 DNA-binding site [nucleotide binding]; DNA binding site 655816001793 UTRA domain; Region: UTRA; cl01230 655816001794 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 655816001795 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 655816001796 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 655816001797 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 655816001798 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 655816001799 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 655816001800 dimanganese center [ion binding]; other site 655816001801 thiamine-monophosphate kinase; Region: thiL; TIGR01379 655816001802 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 655816001803 ATP binding site [chemical binding]; other site 655816001804 dimerization interface [polypeptide binding]; other site 655816001805 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 655816001806 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 655816001807 Glycoprotease family; Region: Peptidase_M22; pfam00814 655816001808 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 655816001809 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816001810 Coenzyme A binding pocket [chemical binding]; other site 655816001811 UGMP family protein; Validated; Region: PRK09604 655816001812 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 655816001813 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 655816001814 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 655816001815 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 655816001816 ABC transporter; Region: ABC_tran_2; pfam12848 655816001817 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 655816001818 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 655816001819 trimer interface [polypeptide binding]; other site 655816001820 dimer interface [polypeptide binding]; other site 655816001821 putative active site [active] 655816001822 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 655816001823 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 655816001824 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816001825 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 655816001826 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 655816001827 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 655816001828 CAAX protease self-immunity; Region: Abi; cl00558 655816001829 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 655816001830 oligomerisation interface [polypeptide binding]; other site 655816001831 mobile loop; other site 655816001832 roof hairpin; other site 655816001833 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 655816001834 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 655816001835 ring oligomerisation interface [polypeptide binding]; other site 655816001836 ATP/Mg binding site [chemical binding]; other site 655816001837 stacking interactions; other site 655816001838 hinge regions; other site 655816001839 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 655816001840 NB-ARC domain; Region: NB-ARC; pfam00931 655816001841 LppC putative lipoprotein; Region: LppC; pfam04348 655816001842 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816001843 binding surface 655816001844 TPR motif; other site 655816001845 TPR repeat; Region: TPR_11; pfam13414 655816001846 L-idonate 5-dehydrogenase; Region: PLN02702 655816001847 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 655816001848 inhibitor binding site; inhibition site 655816001849 catalytic Zn binding site [ion binding]; other site 655816001850 structural Zn binding site [ion binding]; other site 655816001851 NADP binding site [chemical binding]; other site 655816001852 tetramer interface [polypeptide binding]; other site 655816001853 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 655816001854 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 655816001855 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 655816001856 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 655816001857 putative substrate binding site [chemical binding]; other site 655816001858 putative ATP binding site [chemical binding]; other site 655816001859 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 655816001860 DNA-directed RNA polymerase subunit F; Provisional; Region: PRK14981 655816001861 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 655816001862 Repair protein; Region: Repair_PSII; cl01535 655816001863 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 655816001864 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 655816001865 Ion channel; Region: Ion_trans_2; cl11596 655816001866 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 655816001867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816001868 putative substrate translocation pore; other site 655816001869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816001870 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 655816001871 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 655816001872 putative NAD(P) binding site [chemical binding]; other site 655816001873 catalytic Zn binding site [ion binding]; other site 655816001874 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 655816001875 Helix-turn-helix domains; Region: HTH; cl00088 655816001876 putative transposase OrfB; Reviewed; Region: PHA02517 655816001877 HTH-like domain; Region: HTH_21; pfam13276 655816001878 Integrase core domain; Region: rve; cl01316 655816001879 Integrase core domain; Region: rve_3; cl15866 655816001880 Cold-inducible protein YdjO; Region: YdjO; pfam14169 655816001881 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 655816001882 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 655816001883 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 655816001884 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 655816001885 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 655816001886 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 655816001887 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 655816001888 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 655816001889 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 655816001890 Cation efflux family; Region: Cation_efflux; cl00316 655816001891 MoxR-like ATPases [General function prediction only]; Region: COG0714 655816001892 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816001893 Walker A motif; other site 655816001894 ATP binding site [chemical binding]; other site 655816001895 Walker B motif; other site 655816001896 arginine finger; other site 655816001897 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 655816001898 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 655816001899 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 655816001900 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 655816001901 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 655816001902 GMP synthase; Reviewed; Region: guaA; PRK00074 655816001903 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 655816001904 AMP/PPi binding site [chemical binding]; other site 655816001905 candidate oxyanion hole; other site 655816001906 catalytic triad [active] 655816001907 potential glutamine specificity residues [chemical binding]; other site 655816001908 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 655816001909 ATP Binding subdomain [chemical binding]; other site 655816001910 Ligand Binding sites [chemical binding]; other site 655816001911 Dimerization subdomain; other site 655816001912 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 655816001913 Protein of unknown function (DUF3260); Region: DUF3260; cl11881 655816001914 hypothetical protein; Provisional; Region: PRK04164 655816001915 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 655816001916 NETI protein; Region: NETI; pfam14044 655816001917 AIR carboxylase; Region: AIRC; cl00310 655816001918 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 655816001919 ATP-grasp domain; Region: ATP-grasp_4; cl03087 655816001920 adenylosuccinate lyase; Provisional; Region: PRK07492 655816001921 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 655816001922 tetramer interface [polypeptide binding]; other site 655816001923 active site 655816001924 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 655816001925 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 655816001926 ATP binding site [chemical binding]; other site 655816001927 active site 655816001928 substrate binding site [chemical binding]; other site 655816001929 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 655816001930 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 655816001931 putative active site [active] 655816001932 catalytic triad [active] 655816001933 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 655816001934 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 655816001935 dimerization interface [polypeptide binding]; other site 655816001936 ATP binding site [chemical binding]; other site 655816001937 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 655816001938 dimerization interface [polypeptide binding]; other site 655816001939 ATP binding site [chemical binding]; other site 655816001940 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 655816001941 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 655816001942 active site 655816001943 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 655816001944 active site 655816001945 ribose-phosphate pyrophosphokinase; Region: PLN02369 655816001946 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 655816001947 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 655816001948 dimerization interface [polypeptide binding]; other site 655816001949 putative ATP binding site [chemical binding]; other site 655816001950 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 655816001951 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 655816001952 active site 655816001953 substrate binding site [chemical binding]; other site 655816001954 cosubstrate binding site; other site 655816001955 catalytic site [active] 655816001956 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 655816001957 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 655816001958 purine monophosphate binding site [chemical binding]; other site 655816001959 dimer interface [polypeptide binding]; other site 655816001960 putative catalytic residues [active] 655816001961 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 655816001962 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 655816001963 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 655816001964 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 655816001965 ATP-grasp domain; Region: ATP-grasp_4; cl03087 655816001966 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 655816001967 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 655816001968 Helix-turn-helix domains; Region: HTH; cl00088 655816001969 putative transporter; Provisional; Region: PRK11021 655816001970 Spore germination protein; Region: Spore_permease; cl15802 655816001971 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 655816001972 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 655816001973 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 655816001974 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 655816001975 active site 655816001976 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 655816001977 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 655816001978 Helix-turn-helix domains; Region: HTH; cl00088 655816001979 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 655816001980 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 655816001981 active site 655816001982 FMN binding site [chemical binding]; other site 655816001983 substrate binding site [chemical binding]; other site 655816001984 3Fe-4S cluster binding site [ion binding]; other site 655816001985 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 655816001986 substrate binding site [chemical binding]; other site 655816001987 putative active site [active] 655816001988 dimer interface [polypeptide binding]; other site 655816001989 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 655816001990 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816001991 Family description; Region: UvrD_C_2; cl15862 655816001992 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 655816001993 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 655816001994 nucleotide binding pocket [chemical binding]; other site 655816001995 K-X-D-G motif; other site 655816001996 catalytic site [active] 655816001997 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 655816001998 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 655816001999 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 655816002000 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 655816002001 Dimer interface [polypeptide binding]; other site 655816002002 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 655816002003 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 655816002004 active site 655816002005 ATP binding site [chemical binding]; other site 655816002006 substrate binding site [chemical binding]; other site 655816002007 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 655816002008 MgtC family; Region: MgtC; pfam02308 655816002009 Sodium:solute symporter family; Region: SSF; cl00456 655816002010 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 655816002011 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 655816002012 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 655816002013 Amidase; Region: Amidase; cl11426 655816002014 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 655816002015 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 655816002016 GatB domain; Region: GatB_Yqey; cl11497 655816002017 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655816002018 Helix-turn-helix domains; Region: HTH; cl00088 655816002019 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 655816002020 Protein export membrane protein; Region: SecD_SecF; cl14618 655816002021 putative lipid kinase; Reviewed; Region: PRK13337 655816002022 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 655816002023 TRAM domain; Region: TRAM; cl01282 655816002024 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 655816002025 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816002026 S-adenosylmethionine binding site [chemical binding]; other site 655816002027 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 655816002028 HsdM N-terminal domain; Region: HsdM_N; pfam12161 655816002029 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816002030 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 655816002031 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 655816002032 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 655816002033 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 655816002034 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 655816002035 ATP binding site [chemical binding]; other site 655816002036 putative Mg++ binding site [ion binding]; other site 655816002037 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 655816002038 Protein of unknown function, DUF600; Region: DUF600; cl04640 655816002039 Protein of unknown function, DUF600; Region: DUF600; cl04640 655816002040 Uncharacterized conserved protein [Function unknown]; Region: COG5444 655816002041 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 655816002042 Tetratricopeptide repeat; Region: TPR_12; pfam13424 655816002043 Transcriptional regulator; Region: Transcrip_reg; cl00361 655816002044 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655816002045 Helix-turn-helix domains; Region: HTH; cl00088 655816002046 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 655816002047 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 655816002048 NADH(P)-binding; Region: NAD_binding_10; pfam13460 655816002049 NADP binding site [chemical binding]; other site 655816002050 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 655816002051 Helix-turn-helix domains; Region: HTH; cl00088 655816002052 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 655816002053 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 655816002054 CotJB protein; Region: CotJB; pfam12652 655816002055 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 655816002056 dimanganese center [ion binding]; other site 655816002057 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 655816002058 YesK-like protein; Region: YesK; pfam14150 655816002059 Protein of unknown function, DUF624; Region: DUF624; cl02369 655816002060 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 655816002061 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 655816002062 Histidine kinase; Region: His_kinase; pfam06580 655816002063 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816002064 ATP binding site [chemical binding]; other site 655816002065 Mg2+ binding site [ion binding]; other site 655816002066 G-X-G motif; other site 655816002067 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 655816002068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816002069 active site 655816002070 phosphorylation site [posttranslational modification] 655816002071 intermolecular recognition site; other site 655816002072 dimerization interface [polypeptide binding]; other site 655816002073 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655816002074 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 655816002075 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 655816002076 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 655816002077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816002078 dimer interface [polypeptide binding]; other site 655816002079 conserved gate region; other site 655816002080 putative PBP binding loops; other site 655816002081 ABC-ATPase subunit interface; other site 655816002082 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 655816002083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816002084 dimer interface [polypeptide binding]; other site 655816002085 conserved gate region; other site 655816002086 putative PBP binding loops; other site 655816002087 ABC-ATPase subunit interface; other site 655816002088 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 655816002089 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 655816002090 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655816002091 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 655816002092 active site 655816002093 catalytic triad [active] 655816002094 Domain of unknown function (DUF1961); Region: DUF1961; pfam09224 655816002095 Protein of unknown function, DUF624; Region: DUF624; cl02369 655816002096 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 655816002097 metal binding site [ion binding]; metal-binding site 655816002098 active site 655816002099 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 655816002100 metal binding site [ion binding]; metal-binding site 655816002101 active site 655816002102 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 655816002103 active site 655816002104 catalytic triad [active] 655816002105 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 655816002106 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 655816002107 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 655816002108 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 655816002109 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 655816002110 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 655816002111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816002112 putative PBP binding loops; other site 655816002113 dimer interface [polypeptide binding]; other site 655816002114 ABC-ATPase subunit interface; other site 655816002115 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 655816002116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816002117 dimer interface [polypeptide binding]; other site 655816002118 conserved gate region; other site 655816002119 putative PBP binding loops; other site 655816002120 ABC-ATPase subunit interface; other site 655816002121 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 655816002122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816002123 NAD(P) binding site [chemical binding]; other site 655816002124 LDH/MDH dimer interface [polypeptide binding]; other site 655816002125 substrate binding site [chemical binding]; other site 655816002126 Protein of unknown function (DUF421); Region: DUF421; cl00990 655816002127 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 655816002128 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 655816002129 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 655816002130 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 655816002131 Uncharacterized small protein (DUF2292); Region: DUF2292; cl02371 655816002132 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 655816002133 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816002134 Helix-turn-helix domains; Region: HTH; cl00088 655816002135 hypothetical protein; Provisional; Region: PRK06847 655816002136 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816002137 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 655816002138 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 655816002139 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 655816002140 Cytochrome P450; Region: p450; pfam00067 655816002141 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 655816002142 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 655816002143 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 655816002144 FAD binding pocket [chemical binding]; other site 655816002145 FAD binding motif [chemical binding]; other site 655816002146 catalytic residues [active] 655816002147 NAD binding pocket [chemical binding]; other site 655816002148 phosphate binding motif [ion binding]; other site 655816002149 beta-alpha-beta structure motif; other site 655816002150 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 655816002151 Sulfatase; Region: Sulfatase; cl10460 655816002152 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 655816002153 substrate binding site; other site 655816002154 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 655816002155 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816002156 NAD(P) binding site [chemical binding]; other site 655816002157 active site 655816002158 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 655816002159 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 655816002160 active site 655816002161 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 655816002162 Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; cl05288 655816002163 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816002164 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816002165 putative substrate translocation pore; other site 655816002166 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 655816002167 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816002168 active site 655816002169 motif I; other site 655816002170 motif II; other site 655816002171 amino acid transporter; Region: 2A0306; TIGR00909 655816002172 Spore germination protein; Region: Spore_permease; cl15802 655816002173 Spore germination protein; Region: Spore_permease; cl15802 655816002174 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 655816002175 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 655816002176 NAD(P) binding site [chemical binding]; other site 655816002177 catalytic residues [active] 655816002178 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 655816002179 dimer interface [polypeptide binding]; other site 655816002180 putative CheW interface [polypeptide binding]; other site 655816002181 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 655816002182 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816002183 Walker A/P-loop; other site 655816002184 ATP binding site [chemical binding]; other site 655816002185 Q-loop/lid; other site 655816002186 ABC transporter signature motif; other site 655816002187 Walker B; other site 655816002188 D-loop; other site 655816002189 H-loop/switch region; other site 655816002190 ABC transporter; Region: ABC_tran_2; pfam12848 655816002191 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 655816002192 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 655816002193 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 655816002194 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 655816002195 DNA binding residues [nucleotide binding] 655816002196 putative dimer interface [polypeptide binding]; other site 655816002197 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 655816002198 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816002199 putative substrate translocation pore; other site 655816002200 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 655816002201 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816002202 Walker A/P-loop; other site 655816002203 ATP binding site [chemical binding]; other site 655816002204 Q-loop/lid; other site 655816002205 ABC transporter signature motif; other site 655816002206 Walker B; other site 655816002207 D-loop; other site 655816002208 H-loop/switch region; other site 655816002209 ABC transporter; Region: ABC_tran_2; pfam12848 655816002210 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 655816002211 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 655816002212 DEAD-like helicases superfamily; Region: DEXDc; smart00487 655816002213 ATP binding site [chemical binding]; other site 655816002214 Mg++ binding site [ion binding]; other site 655816002215 motif III; other site 655816002216 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655816002217 nucleotide binding region [chemical binding]; other site 655816002218 ATP-binding site [chemical binding]; other site 655816002219 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 655816002220 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 655816002221 Prostaglandin dehydrogenases; Region: PGDH; cd05288 655816002222 NAD(P) binding site [chemical binding]; other site 655816002223 substrate binding site [chemical binding]; other site 655816002224 dimer interface [polypeptide binding]; other site 655816002225 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 655816002226 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 655816002227 Walker A/P-loop; other site 655816002228 ATP binding site [chemical binding]; other site 655816002229 Q-loop/lid; other site 655816002230 ABC transporter signature motif; other site 655816002231 Walker B; other site 655816002232 D-loop; other site 655816002233 H-loop/switch region; other site 655816002234 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655816002235 ABC-ATPase subunit interface; other site 655816002236 dimer interface [polypeptide binding]; other site 655816002237 putative PBP binding regions; other site 655816002238 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655816002239 ABC-ATPase subunit interface; other site 655816002240 dimer interface [polypeptide binding]; other site 655816002241 putative PBP binding regions; other site 655816002242 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 655816002243 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 655816002244 siderophore binding site; other site 655816002245 Protein of unknown function (DUF3212); Region: DUF3212; pfam11486 655816002246 Heat induced stress protein YflT; Region: YflT; pfam11181 655816002247 Pectate lyase; Region: Pec_lyase_C; cl01593 655816002248 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 655816002249 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 655816002250 transmembrane helices; other site 655816002251 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 655816002252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816002253 ATP binding site [chemical binding]; other site 655816002254 Mg2+ binding site [ion binding]; other site 655816002255 G-X-G motif; other site 655816002256 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 655816002257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816002258 active site 655816002259 phosphorylation site [posttranslational modification] 655816002260 intermolecular recognition site; other site 655816002261 dimerization interface [polypeptide binding]; other site 655816002262 Transcriptional regulator; Region: CitT; pfam12431 655816002263 Helix-turn-helix domains; Region: HTH; cl00088 655816002264 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 655816002265 NMT1-like family; Region: NMT1_2; cl15260 655816002266 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 655816002267 Citrate transporter; Region: CitMHS; pfam03600 655816002268 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 655816002269 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 655816002270 active site 655816002271 dimer interface [polypeptide binding]; other site 655816002272 Acylphosphatase; Region: Acylphosphatase; cl00551 655816002273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 655816002274 MOSC domain; Region: MOSC; pfam03473 655816002275 3-alpha domain; Region: 3-alpha; pfam03475 655816002276 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 655816002277 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 655816002278 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 655816002279 active site 655816002280 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 655816002281 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 655816002282 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 655816002283 active site turn [active] 655816002284 phosphorylation site [posttranslational modification] 655816002285 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 655816002286 Sulfatase; Region: Sulfatase; cl10460 655816002287 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 655816002288 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 655816002289 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 655816002290 Spore germination protein; Region: Spore_permease; cl15802 655816002291 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 655816002292 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 655816002293 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 655816002294 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 655816002295 active site turn [active] 655816002296 phosphorylation site [posttranslational modification] 655816002297 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 655816002298 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 655816002299 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 655816002300 Ca binding site [ion binding]; other site 655816002301 active site 655816002302 catalytic site [active] 655816002303 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 655816002304 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816002305 DNA-binding site [nucleotide binding]; DNA binding site 655816002306 UTRA domain; Region: UTRA; cl01230 655816002307 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 655816002308 dimer interface [polypeptide binding]; other site 655816002309 FMN binding site [chemical binding]; other site 655816002310 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09419 655816002311 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 655816002312 active site 655816002313 metal binding site [ion binding]; metal-binding site 655816002314 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 655816002315 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 655816002316 active site 655816002317 metal binding site [ion binding]; metal-binding site 655816002318 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 655816002319 intracellular protease, PfpI family; Region: PfpI; TIGR01382 655816002320 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 655816002321 proposed catalytic triad [active] 655816002322 conserved cys residue [active] 655816002323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816002324 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816002325 putative substrate translocation pore; other site 655816002326 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 655816002327 Low molecular weight phosphatase family; Region: LMWPc; cd00115 655816002328 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 655816002329 active site 655816002330 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 655816002331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816002332 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816002333 putative substrate translocation pore; other site 655816002334 calcium/proton exchanger (cax); Region: cax; TIGR00378 655816002335 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 655816002336 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 655816002337 YfkD-like protein; Region: YfkD; pfam14167 655816002338 Mechanosensitive ion channel; Region: MS_channel; pfam00924 655816002339 Radical SAM superfamily; Region: Radical_SAM; pfam04055 655816002340 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655816002341 FeS/SAM binding site; other site 655816002342 YfkB-like domain; Region: YfkB; pfam08756 655816002343 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 655816002344 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 655816002345 NodB motif; other site 655816002346 active site 655816002347 catalytic site [active] 655816002348 Cd binding site [ion binding]; other site 655816002349 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 655816002350 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816002351 magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383 655816002352 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 655816002353 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 655816002354 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 655816002355 minor groove reading motif; other site 655816002356 helix-hairpin-helix signature motif; other site 655816002357 substrate binding pocket [chemical binding]; other site 655816002358 active site 655816002359 TRAM domain; Region: TRAM; cl01282 655816002360 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 655816002361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816002362 S-adenosylmethionine binding site [chemical binding]; other site 655816002363 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 655816002364 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 655816002365 FMN binding site [chemical binding]; other site 655816002366 active site 655816002367 catalytic residues [active] 655816002368 substrate binding site [chemical binding]; other site 655816002369 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 655816002370 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 655816002371 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 655816002372 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 655816002373 tetramer interface [polypeptide binding]; other site 655816002374 TPP-binding site [chemical binding]; other site 655816002375 heterodimer interface [polypeptide binding]; other site 655816002376 phosphorylation loop region [posttranslational modification] 655816002377 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 655816002378 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 655816002379 alpha subunit interface [polypeptide binding]; other site 655816002380 TPP binding site [chemical binding]; other site 655816002381 heterodimer interface [polypeptide binding]; other site 655816002382 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 655816002383 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 655816002384 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 655816002385 E3 interaction surface; other site 655816002386 lipoyl attachment site [posttranslational modification]; other site 655816002387 e3 binding domain; Region: E3_binding; pfam02817 655816002388 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 655816002389 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 655816002390 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655816002391 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 655816002392 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 655816002393 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816002394 Walker A motif; other site 655816002395 ATP binding site [chemical binding]; other site 655816002396 Walker B motif; other site 655816002397 arginine finger; other site 655816002398 Helix-turn-helix domains; Region: HTH; cl00088 655816002399 Small acid-soluble spore protein H family; Region: SspH; cl06949 655816002400 Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 655816002401 Proteins of 100 residues with WXG; Region: WXG100; cl02005 655816002402 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 655816002403 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 655816002404 NAD binding site [chemical binding]; other site 655816002405 sugar binding site [chemical binding]; other site 655816002406 divalent metal binding site [ion binding]; other site 655816002407 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 655816002408 dimer interface [polypeptide binding]; other site 655816002409 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 655816002410 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 655816002411 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 655816002412 putative active site [active] 655816002413 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 655816002414 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 655816002415 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 655816002416 active site turn [active] 655816002417 phosphorylation site [posttranslational modification] 655816002418 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 655816002419 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 655816002420 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816002421 Walker A/P-loop; other site 655816002422 ATP binding site [chemical binding]; other site 655816002423 Q-loop/lid; other site 655816002424 ABC transporter signature motif; other site 655816002425 Walker B; other site 655816002426 D-loop; other site 655816002427 H-loop/switch region; other site 655816002428 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 655816002429 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 655816002430 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 655816002431 Walker A/P-loop; other site 655816002432 ATP binding site [chemical binding]; other site 655816002433 Q-loop/lid; other site 655816002434 ABC transporter signature motif; other site 655816002435 Walker B; other site 655816002436 D-loop; other site 655816002437 H-loop/switch region; other site 655816002438 DoxX; Region: DoxX; cl00976 655816002439 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 655816002440 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 655816002441 putative metal binding site [ion binding]; other site 655816002442 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 655816002443 active site 655816002444 metal binding site [ion binding]; metal-binding site 655816002445 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 655816002446 Histidine kinase; Region: HisKA_3; pfam07730 655816002447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816002448 ATP binding site [chemical binding]; other site 655816002449 Mg2+ binding site [ion binding]; other site 655816002450 G-X-G motif; other site 655816002451 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 655816002452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816002453 active site 655816002454 phosphorylation site [posttranslational modification] 655816002455 intermolecular recognition site; other site 655816002456 dimerization interface [polypeptide binding]; other site 655816002457 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655816002458 DNA binding residues [nucleotide binding] 655816002459 dimerization interface [polypeptide binding]; other site 655816002460 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816002461 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 655816002462 Walker A/P-loop; other site 655816002463 ATP binding site [chemical binding]; other site 655816002464 Q-loop/lid; other site 655816002465 ABC transporter signature motif; other site 655816002466 Walker B; other site 655816002467 D-loop; other site 655816002468 H-loop/switch region; other site 655816002469 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 655816002470 ABC-2 type transporter; Region: ABC2_membrane; cl11417 655816002471 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 655816002472 ABC-2 type transporter; Region: ABC2_membrane; cl11417 655816002473 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 655816002474 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 655816002475 Helix-turn-helix domains; Region: HTH; cl00088 655816002476 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 655816002477 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 655816002478 OpgC protein; Region: OpgC_C; cl00792 655816002479 Acyltransferase family; Region: Acyl_transf_3; pfam01757 655816002480 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 655816002481 DinB superfamily; Region: DinB_2; pfam12867 655816002482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816002483 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816002484 putative substrate translocation pore; other site 655816002485 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816002486 Helix-turn-helix domains; Region: HTH; cl00088 655816002487 Predicted integral membrane protein [Function unknown]; Region: COG0392 655816002488 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 655816002489 Uncharacterized conserved protein [Function unknown]; Region: COG2898 655816002490 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 655816002491 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 655816002492 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 655816002493 siderophore binding site; other site 655816002494 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655816002495 ABC-ATPase subunit interface; other site 655816002496 dimer interface [polypeptide binding]; other site 655816002497 putative PBP binding regions; other site 655816002498 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655816002499 ABC-ATPase subunit interface; other site 655816002500 dimer interface [polypeptide binding]; other site 655816002501 putative PBP binding regions; other site 655816002502 sequence corresponding to yfhB is present, but has been inactivated by a small deletion resulting in a frameshift 655816002503 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 655816002504 putative FMN binding site [chemical binding]; other site 655816002505 YfhD-like protein; Region: YfhD; pfam14151 655816002506 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 655816002507 TIGR01777 family protein; Region: yfcH 655816002508 putative NAD(P) binding site [chemical binding]; other site 655816002509 putative active site [active] 655816002510 RecX family; Region: RecX; cl00936 655816002511 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 655816002512 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 655816002513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816002514 putative substrate translocation pore; other site 655816002515 Small acid-soluble spore protein K family; Region: SspK; cl11509 655816002516 WVELL protein; Region: WVELL; pfam14043 655816002517 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 655816002518 Bacterial SH3 domain; Region: SH3_3; cl02551 655816002519 SdpI/YhfL protein family; Region: SdpI; pfam13630 655816002520 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 655816002521 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 655816002522 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 655816002523 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 655816002524 Ligand binding site; other site 655816002525 Putative Catalytic site; other site 655816002526 DXD motif; other site 655816002527 Predicted membrane protein [Function unknown]; Region: COG4485 655816002528 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 655816002529 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 655816002530 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 655816002531 minor groove reading motif; other site 655816002532 helix-hairpin-helix signature motif; other site 655816002533 substrate binding pocket [chemical binding]; other site 655816002534 active site 655816002535 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 655816002536 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 655816002537 DNA binding and oxoG recognition site [nucleotide binding] 655816002538 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 655816002539 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 655816002540 putative NAD(P) binding site [chemical binding]; other site 655816002541 active site 655816002542 YgaB-like protein; Region: YgaB; pfam14182 655816002543 Protein of unknown function (DUF402); Region: DUF402; cl00979 655816002544 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 655816002545 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 655816002546 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 655816002547 Walker A/P-loop; other site 655816002548 ATP binding site [chemical binding]; other site 655816002549 Q-loop/lid; other site 655816002550 ABC transporter signature motif; other site 655816002551 Walker B; other site 655816002552 D-loop; other site 655816002553 H-loop/switch region; other site 655816002554 Predicted membrane protein [Function unknown]; Region: COG4129 655816002555 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 655816002556 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 655816002557 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 655816002558 inhibitor-cofactor binding pocket; inhibition site 655816002559 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816002560 catalytic residue [active] 655816002561 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 655816002562 catalytic triad [active] 655816002563 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 655816002564 metal binding site 2 [ion binding]; metal-binding site 655816002565 putative DNA binding helix; other site 655816002566 metal binding site 1 [ion binding]; metal-binding site 655816002567 dimer interface [polypeptide binding]; other site 655816002568 structural Zn2+ binding site [ion binding]; other site 655816002569 Protein of unknown function (DUF2614); Region: DUF2614; cl07936 655816002570 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 655816002571 SpoOM protein; Region: Spo0M; pfam07070 655816002572 Coat F domain; Region: Coat_F; cl15836 655816002573 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 655816002574 active site pocket [active] 655816002575 oxyanion hole [active] 655816002576 catalytic triad [active] 655816002577 active site nucleophile [active] 655816002578 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 655816002579 ThiC-associated domain; Region: ThiC-associated; pfam13667 655816002580 ThiC family; Region: ThiC; cl08031 655816002581 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 655816002582 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 655816002583 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 655816002584 tetramer interface [polypeptide binding]; other site 655816002585 heme binding pocket [chemical binding]; other site 655816002586 NADPH binding site [chemical binding]; other site 655816002587 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 655816002588 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 655816002589 Walker A/P-loop; other site 655816002590 ATP binding site [chemical binding]; other site 655816002591 Q-loop/lid; other site 655816002592 ABC transporter signature motif; other site 655816002593 Walker B; other site 655816002594 D-loop; other site 655816002595 H-loop/switch region; other site 655816002596 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 655816002597 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 655816002598 substrate binding pocket [chemical binding]; other site 655816002599 membrane-bound complex binding site; other site 655816002600 hinge residues; other site 655816002601 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 655816002602 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816002603 dimer interface [polypeptide binding]; other site 655816002604 conserved gate region; other site 655816002605 putative PBP binding loops; other site 655816002606 ABC-ATPase subunit interface; other site 655816002607 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 655816002608 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 655816002609 active site 655816002610 dimer interface [polypeptide binding]; other site 655816002611 non-prolyl cis peptide bond; other site 655816002612 insertion regions; other site 655816002613 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 655816002614 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655816002615 non-specific DNA binding site [nucleotide binding]; other site 655816002616 salt bridge; other site 655816002617 sequence-specific DNA binding site [nucleotide binding]; other site 655816002618 B3/4 domain; Region: B3_4; cl11458 655816002619 iron-sulfur cluster binding protein, putative; Region: TIGR00276 655816002620 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 655816002621 HEAT repeats; Region: HEAT_2; pfam13646 655816002622 NlpC/P60 family; Region: NLPC_P60; cl11438 655816002623 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 655816002624 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 655816002625 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 655816002626 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 655816002627 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 655816002628 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 655816002629 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 655816002630 Uncharacterized conserved protein [Function unknown]; Region: COG2718 655816002631 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 655816002632 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816002633 Helix-turn-helix domains; Region: HTH; cl00088 655816002634 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 655816002635 carboxyltransferase (CT) interaction site; other site 655816002636 biotinylation site [posttranslational modification]; other site 655816002637 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 655816002638 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 655816002639 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816002640 putative substrate translocation pore; other site 655816002641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816002642 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 655816002643 Predicted transcriptional regulators [Transcription]; Region: COG1725 655816002644 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816002645 DNA-binding site [nucleotide binding]; DNA binding site 655816002646 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 655816002647 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 655816002648 Walker A/P-loop; other site 655816002649 ATP binding site [chemical binding]; other site 655816002650 Q-loop/lid; other site 655816002651 ABC transporter signature motif; other site 655816002652 Walker B; other site 655816002653 D-loop; other site 655816002654 H-loop/switch region; other site 655816002655 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 655816002656 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 655816002657 Walker A/P-loop; other site 655816002658 ATP binding site [chemical binding]; other site 655816002659 Q-loop/lid; other site 655816002660 ABC transporter signature motif; other site 655816002661 Walker B; other site 655816002662 D-loop; other site 655816002663 H-loop/switch region; other site 655816002664 ABC-2 type transporter; Region: ABC2_membrane; cl11417 655816002665 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 655816002666 DNA-binding site [nucleotide binding]; DNA binding site 655816002667 RNA-binding motif; other site 655816002668 NMT1-like family; Region: NMT1_2; cl15260 655816002669 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 655816002670 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 655816002671 metal binding site [ion binding]; metal-binding site 655816002672 active site 655816002673 I-site; other site 655816002674 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 655816002675 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 655816002676 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 655816002677 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 655816002678 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 655816002679 Coat F domain; Region: Coat_F; cl15836 655816002680 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG4085 655816002681 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 655816002682 generic binding surface II; other site 655816002683 generic binding surface I; other site 655816002684 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 655816002685 generic binding surface II; other site 655816002686 generic binding surface I; other site 655816002687 Staphylococcal nuclease homologues; Region: SNc; smart00318 655816002688 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 655816002689 Catalytic site; other site 655816002690 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 655816002691 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 655816002692 putative active site [active] 655816002693 putative metal binding site [ion binding]; other site 655816002694 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 655816002695 Gram positive anchor; Region: Gram_pos_anchor; cl15427 655816002696 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 655816002697 active site 655816002698 catalytic site [active] 655816002699 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 655816002700 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 655816002701 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 655816002702 active site 655816002703 FOG: CBS domain [General function prediction only]; Region: COG0517 655816002704 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 655816002705 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 655816002706 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816002707 motif II; other site 655816002708 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816002709 Coenzyme A binding pocket [chemical binding]; other site 655816002710 Predicted amidohydrolase [General function prediction only]; Region: COG0388 655816002711 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 655816002712 putative active site [active] 655816002713 catalytic triad [active] 655816002714 putative dimer interface [polypeptide binding]; other site 655816002715 Membrane transport protein; Region: Mem_trans; cl09117 655816002716 aminotransferase; Validated; Region: PRK07678 655816002717 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 655816002718 inhibitor-cofactor binding pocket; inhibition site 655816002719 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816002720 catalytic residue [active] 655816002721 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 655816002722 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 655816002723 amphipathic channel; other site 655816002724 Asn-Pro-Ala signature motifs; other site 655816002725 glycerol kinase; Provisional; Region: glpK; PRK00047 655816002726 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 655816002727 N- and C-terminal domain interface [polypeptide binding]; other site 655816002728 active site 655816002729 MgATP binding site [chemical binding]; other site 655816002730 catalytic site [active] 655816002731 metal binding site [ion binding]; metal-binding site 655816002732 glycerol binding site [chemical binding]; other site 655816002733 homotetramer interface [polypeptide binding]; other site 655816002734 homodimer interface [polypeptide binding]; other site 655816002735 FBP binding site [chemical binding]; other site 655816002736 protein IIAGlc interface [polypeptide binding]; other site 655816002737 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 655816002738 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 655816002739 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 655816002740 active site 655816002741 substrate binding site [chemical binding]; other site 655816002742 metal binding site [ion binding]; metal-binding site 655816002743 GAF domain; Region: GAF_2; pfam13185 655816002744 GAF domain; Region: GAF; cl15785 655816002745 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 655816002746 Histidine kinase; Region: HisKA_3; pfam07730 655816002747 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816002748 ATP binding site [chemical binding]; other site 655816002749 Mg2+ binding site [ion binding]; other site 655816002750 G-X-G motif; other site 655816002751 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 655816002752 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816002753 active site 655816002754 phosphorylation site [posttranslational modification] 655816002755 intermolecular recognition site; other site 655816002756 dimerization interface [polypeptide binding]; other site 655816002757 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655816002758 DNA binding residues [nucleotide binding] 655816002759 dimerization interface [polypeptide binding]; other site 655816002760 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 655816002761 YhdB-like protein; Region: YhdB; pfam14148 655816002762 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 655816002763 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 655816002764 putative peptidoglycan binding site; other site 655816002765 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 655816002766 putative peptidoglycan binding site; other site 655816002767 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 655816002768 putative peptidoglycan binding site; other site 655816002769 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 655816002770 putative peptidoglycan binding site; other site 655816002771 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 655816002772 putative peptidoglycan binding site; other site 655816002773 NlpC/P60 family; Region: NLPC_P60; cl11438 655816002774 Helix-turn-helix domains; Region: HTH; cl00088 655816002775 Rrf2 family protein; Region: rrf2_super; TIGR00738 655816002776 Conserved TM helix; Region: TM_helix; pfam05552 655816002777 Conserved TM helix; Region: TM_helix; pfam05552 655816002778 Conserved TM helix; Region: TM_helix; pfam05552 655816002779 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 655816002780 SpoVR like protein; Region: SpoVR; pfam04293 655816002781 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 655816002782 dimer interface [polypeptide binding]; other site 655816002783 Alkaline phosphatase homologues; Region: alkPPc; smart00098 655816002784 active site 655816002785 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 655816002786 putative peptidoglycan binding site; other site 655816002787 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 655816002788 putative peptidoglycan binding site; other site 655816002789 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 655816002790 putative peptidoglycan binding site; other site 655816002791 NlpC/P60 family; Region: NLPC_P60; cl11438 655816002792 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655816002793 Helix-turn-helix domains; Region: HTH; cl00088 655816002794 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 655816002795 dimerization interface [polypeptide binding]; other site 655816002796 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 655816002797 dimer interface [polypeptide binding]; other site 655816002798 Citrate synthase; Region: Citrate_synt; pfam00285 655816002799 active site 655816002800 citrylCoA binding site [chemical binding]; other site 655816002801 oxalacetate/citrate binding site [chemical binding]; other site 655816002802 coenzyme A binding site [chemical binding]; other site 655816002803 catalytic triad [active] 655816002804 short chain dehydrogenase; Provisional; Region: PRK06701 655816002805 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 655816002806 NAD binding site [chemical binding]; other site 655816002807 metal binding site [ion binding]; metal-binding site 655816002808 active site 655816002809 amino acid transporter; Region: 2A0306; TIGR00909 655816002810 Spore germination protein; Region: Spore_permease; cl15802 655816002811 Spore germination protein; Region: Spore_permease; cl15802 655816002812 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 655816002813 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 655816002814 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816002815 DNA-binding site [nucleotide binding]; DNA binding site 655816002816 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655816002817 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816002818 homodimer interface [polypeptide binding]; other site 655816002819 catalytic residue [active] 655816002820 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 655816002821 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816002822 Coenzyme A binding pocket [chemical binding]; other site 655816002823 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 655816002824 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 655816002825 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 655816002826 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655816002827 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655816002828 DNA binding residues [nucleotide binding] 655816002829 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 655816002830 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 655816002831 active site 655816002832 catalytic tetrad [active] 655816002833 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 655816002834 putative acyl-acceptor binding pocket; other site 655816002835 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816002836 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 655816002837 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 655816002838 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816002839 NAD(P) binding site [chemical binding]; other site 655816002840 active site 655816002841 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 655816002842 Domain of unknown function DUF21; Region: DUF21; pfam01595 655816002843 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 655816002844 Transporter associated domain; Region: CorC_HlyC; cl08393 655816002845 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 655816002846 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 655816002847 DNA binding residues [nucleotide binding] 655816002848 putative dimer interface [polypeptide binding]; other site 655816002849 aspartate aminotransferase; Provisional; Region: PRK06836 655816002850 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655816002851 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816002852 homodimer interface [polypeptide binding]; other site 655816002853 catalytic residue [active] 655816002854 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 655816002855 Domain of unknown function DUF21; Region: DUF21; pfam01595 655816002856 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 655816002857 Transporter associated domain; Region: CorC_HlyC; cl08393 655816002858 CrcB-like protein; Region: CRCB; cl09114 655816002859 CrcB-like protein; Region: CRCB; cl09114 655816002860 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 655816002861 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 655816002862 active site 655816002863 catalytic site [active] 655816002864 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 655816002865 Mechanosensitive ion channel; Region: MS_channel; pfam00924 655816002866 NAD-dependent deacetylase; Provisional; Region: PRK00481 655816002867 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 655816002868 NAD+ binding site [chemical binding]; other site 655816002869 substrate binding site [chemical binding]; other site 655816002870 Zn binding site [ion binding]; other site 655816002871 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 655816002872 NodB motif; other site 655816002873 active site 655816002874 catalytic site [active] 655816002875 Zn binding site [ion binding]; other site 655816002876 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 655816002877 homodimer interface [polypeptide binding]; other site 655816002878 substrate-cofactor binding pocket; other site 655816002879 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816002880 catalytic residue [active] 655816002881 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 655816002882 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 655816002883 Ligand Binding Site [chemical binding]; other site 655816002884 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 655816002885 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 655816002886 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816002887 Walker A/P-loop; other site 655816002888 ATP binding site [chemical binding]; other site 655816002889 Q-loop/lid; other site 655816002890 ABC transporter signature motif; other site 655816002891 Walker B; other site 655816002892 D-loop; other site 655816002893 H-loop/switch region; other site 655816002894 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 655816002895 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 655816002896 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 655816002897 Walker A/P-loop; other site 655816002898 ATP binding site [chemical binding]; other site 655816002899 Q-loop/lid; other site 655816002900 ABC transporter signature motif; other site 655816002901 Walker B; other site 655816002902 D-loop; other site 655816002903 H-loop/switch region; other site 655816002904 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 655816002905 NADH(P)-binding; Region: NAD_binding_10; pfam13460 655816002906 NAD binding site [chemical binding]; other site 655816002907 substrate binding site [chemical binding]; other site 655816002908 putative active site [active] 655816002909 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 655816002910 ATP-grasp domain; Region: ATP-grasp_4; cl03087 655816002911 ATP-grasp domain; Region: ATP-grasp_4; cl03087 655816002912 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 655816002913 Protein of unknown function (DUF964); Region: DUF964; cl01483 655816002914 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 655816002915 HEAT repeats; Region: HEAT_2; pfam13646 655816002916 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816002917 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 655816002918 active site 655816002919 motif I; other site 655816002920 motif II; other site 655816002921 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 655816002922 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 655816002923 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655816002924 FeS/SAM binding site; other site 655816002925 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 655816002926 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 655816002927 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 655816002928 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 655816002929 enoyl-CoA hydratase; Provisional; Region: PRK07659 655816002930 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 655816002931 substrate binding site [chemical binding]; other site 655816002932 oxyanion hole (OAH) forming residues; other site 655816002933 trimer interface [polypeptide binding]; other site 655816002934 YhzD-like protein; Region: YhzD; pfam14120 655816002935 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 655816002936 This subfamily is involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity. In eubacteria and archaea, the typical organization consists of one ABC and one or two IMs. Eukaryote systems of the ABCA subfamily...; Region: ABC_putative_ATPase; cd03269 655816002937 Walker A/P-loop; other site 655816002938 ATP binding site [chemical binding]; other site 655816002939 Q-loop/lid; other site 655816002940 ABC transporter signature motif; other site 655816002941 Walker B; other site 655816002942 D-loop; other site 655816002943 H-loop/switch region; other site 655816002944 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 655816002945 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 655816002946 ABC-2 type transporter; Region: ABC2_membrane; cl11417 655816002947 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 655816002948 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 655816002949 active site 655816002950 metal binding site [ion binding]; metal-binding site 655816002951 DNA binding site [nucleotide binding] 655816002952 Uncharacterized conserved protein [Function unknown]; Region: COG4717 655816002953 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 655816002954 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 655816002955 generic binding surface II; other site 655816002956 generic binding surface I; other site 655816002957 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 655816002958 Zn2+ binding site [ion binding]; other site 655816002959 Mg2+ binding site [ion binding]; other site 655816002960 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 655816002961 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 655816002962 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 655816002963 PPIC-type PPIASE domain; Region: Rotamase; cl08278 655816002964 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 655816002965 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 655816002966 transcriptional regulator Hpr; Provisional; Region: PRK13777 655816002967 Helix-turn-helix domains; Region: HTH; cl00088 655816002968 YtxH-like protein; Region: YtxH; cl02079 655816002969 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 655816002970 homodimer interface [polypeptide binding]; other site 655816002971 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 655816002972 substrate-cofactor binding pocket; other site 655816002973 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816002974 catalytic residue [active] 655816002975 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 655816002976 HIT family signature motif; other site 655816002977 catalytic residue [active] 655816002978 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 655816002979 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 655816002980 Walker A/P-loop; other site 655816002981 ATP binding site [chemical binding]; other site 655816002982 Q-loop/lid; other site 655816002983 ABC transporter signature motif; other site 655816002984 Walker B; other site 655816002985 D-loop; other site 655816002986 H-loop/switch region; other site 655816002987 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 655816002988 EcsC protein family; Region: EcsC; pfam12787 655816002989 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 655816002990 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 655816002991 metal binding site [ion binding]; metal-binding site 655816002992 dimer interface [polypeptide binding]; other site 655816002993 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 655816002994 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 655816002995 Transglycosylase; Region: Transgly; cl07896 655816002996 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 655816002997 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 655816002998 methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463 655816002999 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 655816003000 substrate binding site [chemical binding]; other site 655816003001 active site 655816003002 ferrochelatase; Provisional; Region: PRK12435 655816003003 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 655816003004 C-terminal domain interface [polypeptide binding]; other site 655816003005 active site 655816003006 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 655816003007 active site 655816003008 N-terminal domain interface [polypeptide binding]; other site 655816003009 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 655816003010 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816003011 SEA domain; Region: SEA; cl02507 655816003012 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655816003013 Helix-turn-helix domains; Region: HTH; cl00088 655816003014 Predicted membrane protein [Function unknown]; Region: COG1511 655816003015 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 655816003016 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 655816003017 ABC-2 type transporter; Region: ABC2_membrane; cl11417 655816003018 ABC-2 type transporter; Region: ABC2_membrane; cl11417 655816003019 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 655816003020 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 655816003021 dimer interface [polypeptide binding]; other site 655816003022 active site 655816003023 CoA binding pocket [chemical binding]; other site 655816003024 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 655816003025 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 655816003026 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 655816003027 putative oligomer interface [polypeptide binding]; other site 655816003028 putative active site [active] 655816003029 metal binding site [ion binding]; metal-binding site 655816003030 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 655816003031 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 655816003032 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 655816003033 YhfH-like protein; Region: YhfH; pfam14149 655816003034 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 655816003035 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 655816003036 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 655816003037 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 655816003038 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 655816003039 NADH(P)-binding; Region: NAD_binding_10; pfam13460 655816003040 NAD(P) binding site [chemical binding]; other site 655816003041 putative active site [active] 655816003042 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 655816003043 AMP-binding enzyme; Region: AMP-binding; cl15778 655816003044 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 655816003045 Peptidase family M48; Region: Peptidase_M48; cl12018 655816003046 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 655816003047 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 655816003048 active site 655816003049 catalytic residues [active] 655816003050 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 655816003051 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816003052 Coenzyme A binding pocket [chemical binding]; other site 655816003053 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 655816003054 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 655816003055 putative NADP binding site [chemical binding]; other site 655816003056 putative dimer interface [polypeptide binding]; other site 655816003057 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 655816003058 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 655816003059 siderophore binding site; other site 655816003060 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 655816003061 catalytic core [active] 655816003062 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 655816003063 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 655816003064 dimer interface [polypeptide binding]; other site 655816003065 active site 655816003066 acyl-CoA synthetase; Validated; Region: PRK07638 655816003067 AMP-binding enzyme; Region: AMP-binding; cl15778 655816003068 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 655816003069 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 655816003070 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 655816003071 heme-binding site [chemical binding]; other site 655816003072 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 655816003073 Active site flap [active] 655816003074 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 655816003075 dimer interface [polypeptide binding]; other site 655816003076 putative CheW interface [polypeptide binding]; other site 655816003077 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816003078 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 655816003079 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 655816003080 [2Fe-2S] cluster binding site [ion binding]; other site 655816003081 short chain dehydrogenase; Provisional; Region: PRK06701 655816003082 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 655816003083 NAD binding site [chemical binding]; other site 655816003084 metal binding site [ion binding]; metal-binding site 655816003085 active site 655816003086 IDEAL domain; Region: IDEAL; cl07452 655816003087 ComK protein; Region: ComK; cl11560 655816003088 oxidoreductase; Provisional; Region: PRK07985 655816003089 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 655816003090 NAD binding site [chemical binding]; other site 655816003091 metal binding site [ion binding]; metal-binding site 655816003092 active site 655816003093 Sodium:solute symporter family; Region: SSF; cl00456 655816003094 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 655816003095 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 655816003096 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 655816003097 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 655816003098 Catalytic site [active] 655816003099 hypothetical protein; Provisional; Region: PRK08244 655816003100 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816003101 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816003102 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816003103 Helix-turn-helix domains; Region: HTH; cl00088 655816003104 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 655816003105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816003106 putative substrate translocation pore; other site 655816003107 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816003108 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 655816003109 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 655816003110 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 655816003111 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816003112 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 655816003113 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 655816003114 inhibitor-cofactor binding pocket; inhibition site 655816003115 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816003116 catalytic residue [active] 655816003117 Transcriptional regulators [Transcription]; Region: PurR; COG1609 655816003118 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655816003119 DNA binding site [nucleotide binding] 655816003120 domain linker motif; other site 655816003121 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 655816003122 putative dimerization interface [polypeptide binding]; other site 655816003123 putative ligand binding site [chemical binding]; other site 655816003124 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 655816003125 Putative ammonia monooxygenase; Region: AmoA; pfam05145 655816003126 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 655816003127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816003128 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816003129 putative substrate translocation pore; other site 655816003130 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 655816003131 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 655816003132 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 655816003133 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 655816003134 dimerization interface [polypeptide binding]; other site 655816003135 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 655816003136 dinuclear metal binding motif [ion binding]; other site 655816003137 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 655816003138 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 655816003139 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 655816003140 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816003141 Family description; Region: UvrD_C_2; cl15862 655816003142 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 655816003143 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 655816003144 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 655816003145 active site 655816003146 metal binding site [ion binding]; metal-binding site 655816003147 DNA binding site [nucleotide binding] 655816003148 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 655816003149 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 655816003150 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 655816003151 Walker A/P-loop; other site 655816003152 ATP binding site [chemical binding]; other site 655816003153 Q-loop/lid; other site 655816003154 ABC transporter signature motif; other site 655816003155 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 655816003156 ABC transporter signature motif; other site 655816003157 Walker B; other site 655816003158 D-loop; other site 655816003159 H-loop/switch region; other site 655816003160 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 655816003161 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 655816003162 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 655816003163 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 655816003164 Spore germination protein GerPC; Region: GerPC; pfam10737 655816003165 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 655816003166 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 655816003167 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 655816003168 CotH protein; Region: CotH; pfam08757 655816003169 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 655816003170 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 655816003171 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 655816003172 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 655816003173 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 655816003174 active site 655816003175 catalytic triad [active] 655816003176 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 655816003177 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 655816003178 active site 655816003179 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 655816003180 dimer interface [polypeptide binding]; other site 655816003181 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 655816003182 Ligand Binding Site [chemical binding]; other site 655816003183 Molecular Tunnel; other site 655816003184 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 655816003185 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 655816003186 substrate binding pocket [chemical binding]; other site 655816003187 aspartate-rich region 2; other site 655816003188 substrate-Mg2+ binding site; other site 655816003189 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 655816003190 MatE; Region: MatE; cl10513 655816003191 MatE; Region: MatE; cl10513 655816003192 Cupin domain; Region: Cupin_2; cl09118 655816003193 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655816003194 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 655816003195 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655816003196 Transcriptional regulators [Transcription]; Region: PurR; COG1609 655816003197 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655816003198 DNA binding site [nucleotide binding] 655816003199 domain linker motif; other site 655816003200 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 655816003201 dimerization interface [polypeptide binding]; other site 655816003202 ligand binding site [chemical binding]; other site 655816003203 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 655816003204 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816003205 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 655816003206 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 655816003207 LysE type translocator; Region: LysE; cl00565 655816003208 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 655816003209 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816003210 DNA-binding site [nucleotide binding]; DNA binding site 655816003211 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655816003212 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816003213 homodimer interface [polypeptide binding]; other site 655816003214 catalytic residue [active] 655816003215 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 655816003216 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 655816003217 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 655816003218 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 655816003219 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 655816003220 ligand-binding site [chemical binding]; other site 655816003221 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 655816003222 ATP-sulfurylase; Region: ATPS; cd00517 655816003223 active site 655816003224 HXXH motif; other site 655816003225 flexible loop; other site 655816003226 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 655816003227 Active Sites [active] 655816003228 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 655816003229 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 655816003230 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782 655816003231 Uncharacterized conserved protein [Function unknown]; Region: COG1284 655816003232 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 655816003233 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 655816003234 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 655816003235 active site pocket [active] 655816003236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816003237 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816003238 putative substrate translocation pore; other site 655816003239 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 655816003240 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 655816003241 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 655816003242 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 655816003243 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 655816003244 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 655816003245 FAD binding site [chemical binding]; other site 655816003246 Protein of unknown function (DUF520); Region: DUF520; cl00723 655816003247 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 655816003248 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 655816003249 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 655816003250 RNA binding site [nucleotide binding]; other site 655816003251 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 655816003252 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 655816003253 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 655816003254 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 655816003255 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 655816003256 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 655816003257 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 655816003258 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816003259 motif II; other site 655816003260 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816003261 esterase; Provisional; Region: PRK10566 655816003262 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 655816003263 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 655816003264 Domain of unknown function DUF59; Region: DUF59; cl00941 655816003265 Proteolipid membrane potential modulator; Region: Pmp3; cl00431 655816003266 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 655816003267 FAD binding domain; Region: FAD_binding_4; pfam01565 655816003268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816003269 putative substrate translocation pore; other site 655816003270 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 655816003271 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816003272 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 655816003273 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 655816003274 heterotetramer interface [polypeptide binding]; other site 655816003275 active site pocket [active] 655816003276 cleavage site 655816003277 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 655816003278 nucleotide binding site [chemical binding]; other site 655816003279 N-acetyl-L-glutamate binding site [chemical binding]; other site 655816003280 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 655816003281 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 655816003282 inhibitor-cofactor binding pocket; inhibition site 655816003283 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816003284 catalytic residue [active] 655816003285 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 655816003286 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 655816003287 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 655816003288 catalytic site [active] 655816003289 subunit interface [polypeptide binding]; other site 655816003290 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 655816003291 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 655816003292 ATP-grasp domain; Region: ATP-grasp_4; cl03087 655816003293 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 655816003294 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 655816003295 ATP-grasp domain; Region: ATP-grasp_4; cl03087 655816003296 ornithine carbamoyltransferase; Provisional; Region: PRK00779 655816003297 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 655816003298 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816003299 YjzC-like protein; Region: YjzC; pfam14168 655816003300 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 655816003301 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 655816003302 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 655816003303 putative ligand binding site [chemical binding]; other site 655816003304 ComZ; Region: ComZ; pfam10815 655816003305 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 655816003306 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 655816003307 dimer interface [polypeptide binding]; other site 655816003308 active site 655816003309 CoA binding pocket [chemical binding]; other site 655816003310 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 655816003311 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 655816003312 dimer interface [polypeptide binding]; other site 655816003313 active site 655816003314 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 655816003315 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 655816003316 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 655816003317 Walker A/P-loop; other site 655816003318 ATP binding site [chemical binding]; other site 655816003319 Q-loop/lid; other site 655816003320 ABC transporter signature motif; other site 655816003321 Walker B; other site 655816003322 D-loop; other site 655816003323 H-loop/switch region; other site 655816003324 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 655816003325 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 655816003326 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 655816003327 Walker A/P-loop; other site 655816003328 ATP binding site [chemical binding]; other site 655816003329 Q-loop/lid; other site 655816003330 ABC transporter signature motif; other site 655816003331 Walker B; other site 655816003332 D-loop; other site 655816003333 H-loop/switch region; other site 655816003334 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 655816003335 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 655816003336 peptide binding site [polypeptide binding]; other site 655816003337 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 655816003338 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 655816003339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816003340 dimer interface [polypeptide binding]; other site 655816003341 conserved gate region; other site 655816003342 putative PBP binding loops; other site 655816003343 ABC-ATPase subunit interface; other site 655816003344 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 655816003345 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 655816003346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816003347 dimer interface [polypeptide binding]; other site 655816003348 conserved gate region; other site 655816003349 putative PBP binding loops; other site 655816003350 ABC-ATPase subunit interface; other site 655816003351 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 655816003352 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 655816003353 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 655816003354 active site 655816003355 HIGH motif; other site 655816003356 dimer interface [polypeptide binding]; other site 655816003357 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 655816003358 KMSKS motif; other site 655816003359 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 655816003360 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 655816003361 peptide binding site [polypeptide binding]; other site 655816003362 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 655816003363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816003364 dimer interface [polypeptide binding]; other site 655816003365 conserved gate region; other site 655816003366 putative PBP binding loops; other site 655816003367 ABC-ATPase subunit interface; other site 655816003368 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 655816003369 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 655816003370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816003371 dimer interface [polypeptide binding]; other site 655816003372 conserved gate region; other site 655816003373 putative PBP binding loops; other site 655816003374 ABC-ATPase subunit interface; other site 655816003375 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 655816003376 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 655816003377 Walker A/P-loop; other site 655816003378 ATP binding site [chemical binding]; other site 655816003379 Q-loop/lid; other site 655816003380 ABC transporter signature motif; other site 655816003381 Walker B; other site 655816003382 D-loop; other site 655816003383 H-loop/switch region; other site 655816003384 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 655816003385 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 655816003386 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 655816003387 Walker A/P-loop; other site 655816003388 ATP binding site [chemical binding]; other site 655816003389 Q-loop/lid; other site 655816003390 ABC transporter signature motif; other site 655816003391 Walker B; other site 655816003392 D-loop; other site 655816003393 H-loop/switch region; other site 655816003394 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 655816003395 H+ Antiporter protein; Region: 2A0121; TIGR00900 655816003396 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 655816003397 ArsC family; Region: ArsC; pfam03960 655816003398 putative catalytic residues [active] 655816003399 thiol/disulfide switch; other site 655816003400 Integral membrane protein TerC family; Region: TerC; cl10468 655816003401 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 655816003402 Competence protein CoiA-like family; Region: CoiA; cl11541 655816003403 oligoendopeptidase F; Region: pepF; TIGR00181 655816003404 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 655816003405 active site 655816003406 Zn binding site [ion binding]; other site 655816003407 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 655816003408 Thioredoxin; Region: Thioredoxin_5; pfam13743 655816003409 catalytic residues [active] 655816003410 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 655816003411 apolar tunnel; other site 655816003412 heme binding site [chemical binding]; other site 655816003413 dimerization interface [polypeptide binding]; other site 655816003414 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 655816003415 N-acetyl-D-glucosamine binding site [chemical binding]; other site 655816003416 catalytic residue [active] 655816003417 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 655816003418 putative active site [active] 655816003419 putative metal binding residues [ion binding]; other site 655816003420 signature motif; other site 655816003421 putative triphosphate binding site [ion binding]; other site 655816003422 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 655816003423 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 655816003424 synthetase active site [active] 655816003425 NTP binding site [chemical binding]; other site 655816003426 metal binding site [ion binding]; metal-binding site 655816003427 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 655816003428 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 655816003429 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 655816003430 active site 655816003431 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 655816003432 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 655816003433 active site 655816003434 metal binding site [ion binding]; metal-binding site 655816003435 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 655816003436 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 655816003437 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 655816003438 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816003439 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 655816003440 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 655816003441 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 655816003442 thiamine phosphate binding site [chemical binding]; other site 655816003443 active site 655816003444 pyrophosphate binding site [ion binding]; other site 655816003445 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 655816003446 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 655816003447 thiS-thiF/thiG interaction site; other site 655816003448 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 655816003449 ThiS interaction site; other site 655816003450 putative active site [active] 655816003451 tetramer interface [polypeptide binding]; other site 655816003452 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 655816003453 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 655816003454 ATP binding site [chemical binding]; other site 655816003455 substrate interface [chemical binding]; other site 655816003456 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 655816003457 dimer interface [polypeptide binding]; other site 655816003458 substrate binding site [chemical binding]; other site 655816003459 ATP binding site [chemical binding]; other site 655816003460 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 655816003461 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 655816003462 NAD binding site [chemical binding]; other site 655816003463 homotetramer interface [polypeptide binding]; other site 655816003464 homodimer interface [polypeptide binding]; other site 655816003465 substrate binding site [chemical binding]; other site 655816003466 active site 655816003467 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 655816003468 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 655816003469 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 655816003470 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 655816003471 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 655816003472 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 655816003473 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 655816003474 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 655816003475 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 655816003476 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816003477 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816003478 Family description; Region: UvrD_C_2; cl15862 655816003479 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816003480 Coenzyme A binding pocket [chemical binding]; other site 655816003481 hypothetical protein; Provisional; Region: PRK13679 655816003482 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 655816003483 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 655816003484 Putative esterase; Region: Esterase; pfam00756 655816003485 cystathionine gamma-synthase; Reviewed; Region: PRK08247 655816003486 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 655816003487 homodimer interface [polypeptide binding]; other site 655816003488 substrate-cofactor binding pocket; other site 655816003489 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816003490 catalytic residue [active] 655816003491 cystathionine beta-lyase; Provisional; Region: PRK08064 655816003492 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 655816003493 homodimer interface [polypeptide binding]; other site 655816003494 substrate-cofactor binding pocket; other site 655816003495 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816003496 catalytic residue [active] 655816003497 Protein of unknown function (DUF819); Region: DUF819; cl02317 655816003498 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 655816003499 amidase catalytic site [active] 655816003500 Zn binding residues [ion binding]; other site 655816003501 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 655816003502 Uncharacterized conserved protein [Function unknown]; Region: COG5444 655816003503 Uncharacterized conserved protein [Function unknown]; Region: COG5444 655816003504 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 655816003505 binding surface 655816003506 TPR motif; other site 655816003507 Tetratricopeptide repeat; Region: TPR_12; pfam13424 655816003508 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816003509 binding surface 655816003510 Tetratricopeptide repeat; Region: TPR_12; pfam13424 655816003511 TPR motif; other site 655816003512 Tetratricopeptide repeat; Region: TPR_12; pfam13424 655816003513 YolD-like protein; Region: YolD; pfam08863 655816003514 sequence corresponding to manR is present, but is apparently inactivated by frameshift 655816003515 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 655816003516 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 655816003517 P-loop; other site 655816003518 active site 655816003519 phosphorylation site [posttranslational modification] 655816003520 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 655816003521 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 655816003522 active site 655816003523 phosphorylation site [posttranslational modification] 655816003524 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 655816003525 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 655816003526 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 655816003527 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 655816003528 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 655816003529 putative deacylase active site [active] 655816003530 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 655816003531 UbiA prenyltransferase family; Region: UbiA; cl00337 655816003532 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 655816003533 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 655816003534 Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947 655816003535 NodB motif; other site 655816003536 active site 655816003537 catalytic site [active] 655816003538 Zn binding site [ion binding]; other site 655816003539 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 655816003540 Putative motility protein; Region: YjfB_motility; pfam14070 655816003541 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 655816003542 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 655816003543 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 655816003544 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 655816003545 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 655816003546 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 655816003547 4Fe-4S binding domain; Region: Fer4; cl02805 655816003548 4Fe-4S binding domain; Region: Fer4; cl02805 655816003549 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 655816003550 [4Fe-4S] binding site [ion binding]; other site 655816003551 molybdopterin cofactor binding site; other site 655816003552 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 655816003553 molybdopterin cofactor binding site; other site 655816003554 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 655816003555 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 655816003556 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 655816003557 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 655816003558 nudix motif; other site 655816003559 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 655816003560 Cytochrome P450; Region: p450; pfam00067 655816003561 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 655816003562 glycosyltransferase, MGT family; Region: MGT; TIGR01426 655816003563 active site 655816003564 TDP-binding site; other site 655816003565 acceptor substrate-binding pocket; other site 655816003566 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 655816003567 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 655816003568 active site 655816003569 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 655816003570 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 655816003571 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 655816003572 Walker A/P-loop; other site 655816003573 ATP binding site [chemical binding]; other site 655816003574 Q-loop/lid; other site 655816003575 ABC transporter signature motif; other site 655816003576 Walker B; other site 655816003577 D-loop; other site 655816003578 H-loop/switch region; other site 655816003579 EamA-like transporter family; Region: EamA; cl01037 655816003580 Cupin domain; Region: Cupin_2; cl09118 655816003581 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 655816003582 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 655816003583 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655816003584 Glucuronate isomerase; Region: UxaC; cl00829 655816003585 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 655816003586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816003587 putative substrate translocation pore; other site 655816003588 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 655816003589 putative oxidoreductase; Provisional; Region: PRK10083 655816003590 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 655816003591 putative NAD(P) binding site [chemical binding]; other site 655816003592 catalytic Zn binding site [ion binding]; other site 655816003593 structural Zn binding site [ion binding]; other site 655816003594 mannonate dehydratase; Provisional; Region: PRK03906 655816003595 mannonate dehydratase; Region: uxuA; TIGR00695 655816003596 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 655816003597 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 655816003598 putative NAD(P) binding site [chemical binding]; other site 655816003599 active site 655816003600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816003601 D-galactonate transporter; Region: 2A0114; TIGR00893 655816003602 putative substrate translocation pore; other site 655816003603 Transcriptional regulators [Transcription]; Region: PurR; COG1609 655816003604 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655816003605 DNA binding site [nucleotide binding] 655816003606 domain linker motif; other site 655816003607 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 655816003608 dimerization interface [polypeptide binding]; other site 655816003609 ligand binding site [chemical binding]; other site 655816003610 altronate oxidoreductase; Provisional; Region: PRK03643 655816003611 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 655816003612 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 655816003613 SAF domain; Region: SAF; cl00555 655816003614 Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721 655816003615 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 655816003616 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 655816003617 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 655816003618 DinB superfamily; Region: DinB_2; pfam12867 655816003619 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 655816003620 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816003621 Walker A motif; other site 655816003622 ATP binding site [chemical binding]; other site 655816003623 Walker B motif; other site 655816003624 arginine finger; other site 655816003625 Tetratricopeptide repeat; Region: TPR_12; pfam13424 655816003626 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 655816003627 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 655816003628 YCII-related domain; Region: YCII; cl00999 655816003629 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 655816003630 amidase catalytic site [active] 655816003631 Zn binding residues [ion binding]; other site 655816003632 substrate binding site [chemical binding]; other site 655816003633 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 655816003634 putative peptidoglycan binding site; other site 655816003635 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 655816003636 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 655816003637 Protein of unknown function (DUF867); Region: DUF867; cl01713 655816003638 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 655816003639 dimanganese center [ion binding]; other site 655816003640 Domain of unknown function (DUF955); Region: DUF955; cl01076 655816003641 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655816003642 non-specific DNA binding site [nucleotide binding]; other site 655816003643 salt bridge; other site 655816003644 sequence-specific DNA binding site [nucleotide binding]; other site 655816003645 DNA replication protein DnaC; Validated; Region: PRK07952 655816003646 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816003647 Walker A motif; other site 655816003648 ATP binding site [chemical binding]; other site 655816003649 Walker B motif; other site 655816003650 positive control sigma-like factor; Validated; Region: PRK06930 655816003651 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655816003652 DNA binding residues [nucleotide binding] 655816003653 Phage terminase small subunit; Region: Phage_terminase; pfam10668 655816003654 Terminase small subunit; Region: Terminase_2; cl01513 655816003655 Phage terminase large subunit; Region: Terminase_3; cl12054 655816003656 Terminase-like family; Region: Terminase_6; pfam03237 655816003657 Phage-related protein [Function unknown]; Region: COG4695; cl01923 655816003658 phage portal protein, PBSX family; Region: portal_PBSX; TIGR01540 655816003659 Phage capsid family; Region: Phage_capsid; pfam05065 655816003660 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 655816003661 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 655816003662 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 655816003663 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 655816003664 Phage XkdN-like protein; Region: XkdN; pfam08890 655816003665 CRISPR/Cas system-associated protein Cas8b; Region: Cas8b_I-B; cl09718 655816003666 Phage-related protein [Function unknown]; Region: COG5412 655816003667 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 655816003668 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 655816003669 N-acetyl-D-glucosamine binding site [chemical binding]; other site 655816003670 catalytic residue [active] 655816003671 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 655816003672 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 655816003673 putative peptidoglycan binding site; other site 655816003674 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 655816003675 Protein of unknown function (DUF2577); Region: DUF2577; pfam10844 655816003676 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 655816003677 Baseplate J-like protein; Region: Baseplate_J; cl01294 655816003678 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 655816003679 XkdW protein; Region: XkdW; pfam09636 655816003680 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 655816003681 Haemolysin XhlA; Region: XhlA; pfam10779 655816003682 Phage lysis protein, holin; Region: Phage_holin; cl04675 655816003683 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 655816003684 amidase catalytic site [active] 655816003685 Zn binding residues [ion binding]; other site 655816003686 substrate binding site [chemical binding]; other site 655816003687 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 655816003688 putative peptidoglycan binding site; other site 655816003689 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 655816003690 Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185 655816003691 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 655816003692 Phosphate transporter family; Region: PHO4; cl00396 655816003693 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 655816003694 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 655816003695 Spore germination protein; Region: Spore_permease; cl15802 655816003696 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 655816003697 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 655816003698 Zn binding site [ion binding]; other site 655816003699 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 655816003700 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 655816003701 Zn binding site [ion binding]; other site 655816003702 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 655816003703 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 655816003704 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 655816003705 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 655816003706 Ligand binding site; other site 655816003707 Putative Catalytic site; other site 655816003708 DXD motif; other site 655816003709 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 655816003710 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 655816003711 protein binding site [polypeptide binding]; other site 655816003712 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816003713 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 655816003714 D-alanyl-aminopeptidase 655816003715 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 655816003716 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816003717 dimer interface [polypeptide binding]; other site 655816003718 conserved gate region; other site 655816003719 putative PBP binding loops; other site 655816003720 ABC-ATPase subunit interface; other site 655816003721 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 655816003722 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 655816003723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816003724 dimer interface [polypeptide binding]; other site 655816003725 conserved gate region; other site 655816003726 putative PBP binding loops; other site 655816003727 ABC-ATPase subunit interface; other site 655816003728 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 655816003729 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 655816003730 Walker A/P-loop; other site 655816003731 ATP binding site [chemical binding]; other site 655816003732 Q-loop/lid; other site 655816003733 ABC transporter signature motif; other site 655816003734 Walker B; other site 655816003735 D-loop; other site 655816003736 H-loop/switch region; other site 655816003737 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 655816003738 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 655816003739 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 655816003740 peptide binding site [polypeptide binding]; other site 655816003741 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 655816003742 dimer interface [polypeptide binding]; other site 655816003743 catalytic triad [active] 655816003744 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 655816003745 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 655816003746 active site 655816003747 NlpC/P60 family; Region: NLPC_P60; cl11438 655816003748 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 655816003749 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 655816003750 Walker A/P-loop; other site 655816003751 ATP binding site [chemical binding]; other site 655816003752 Q-loop/lid; other site 655816003753 ABC transporter signature motif; other site 655816003754 Walker B; other site 655816003755 D-loop; other site 655816003756 H-loop/switch region; other site 655816003757 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 655816003758 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 655816003759 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 655816003760 Amidinotransferase; Region: Amidinotransf; cl12043 655816003761 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 655816003762 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 655816003763 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 655816003764 heme-binding site [chemical binding]; other site 655816003765 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 655816003766 FAD binding pocket [chemical binding]; other site 655816003767 FAD binding motif [chemical binding]; other site 655816003768 phosphate binding motif [ion binding]; other site 655816003769 beta-alpha-beta structure motif; other site 655816003770 NAD binding pocket [chemical binding]; other site 655816003771 Heme binding pocket [chemical binding]; other site 655816003772 Protein of unknown function (DUF421); Region: DUF421; cl00990 655816003773 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 655816003774 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 655816003775 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 655816003776 riboswitch leader; may function to switch on expression of the ykkC efflux pump gene in response to toxic compounds; BSUW23_misc_RNA_16 655816003777 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 655816003778 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 655816003779 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 655816003780 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 655816003781 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 655816003782 putative active site [active] 655816003783 putative substrate binding site [chemical binding]; other site 655816003784 putative cosubstrate binding site; other site 655816003785 catalytic site [active] 655816003786 glutamate 5-kinase; Region: proB; TIGR01027 655816003787 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 655816003788 nucleotide binding site [chemical binding]; other site 655816003789 homotetrameric interface [polypeptide binding]; other site 655816003790 putative phosphate binding site [ion binding]; other site 655816003791 putative allosteric binding site; other site 655816003792 PUA domain; Region: PUA; cl00607 655816003793 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 655816003794 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 655816003795 putative catalytic cysteine [active] 655816003796 OsmC-like protein; Region: OsmC; cl00767 655816003797 Helix-turn-helix domains; Region: HTH; cl00088 655816003798 OsmC-like protein; Region: OsmC; cl00767 655816003799 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 655816003800 putative metal binding site; other site 655816003801 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816003802 binding surface 655816003803 TPR motif; other site 655816003804 TPR repeat; Region: TPR_11; pfam13414 655816003805 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 655816003806 nucleoside/Zn binding site; other site 655816003807 dimer interface [polypeptide binding]; other site 655816003808 catalytic motif [active] 655816003809 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 655816003810 catalytic core [active] 655816003811 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 655816003812 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 655816003813 THF binding site; other site 655816003814 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 655816003815 substrate binding site [chemical binding]; other site 655816003816 THF binding site; other site 655816003817 zinc-binding site [ion binding]; other site 655816003818 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 655816003819 active site 655816003820 catalytic residues [active] 655816003821 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 655816003822 Cobalt transport protein; Region: CbiQ; cl00463 655816003823 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 655816003824 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 655816003825 Walker A/P-loop; other site 655816003826 ATP binding site [chemical binding]; other site 655816003827 Q-loop/lid; other site 655816003828 ABC transporter signature motif; other site 655816003829 Walker B; other site 655816003830 D-loop; other site 655816003831 H-loop/switch region; other site 655816003832 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 655816003833 Walker A/P-loop; other site 655816003834 ATP binding site [chemical binding]; other site 655816003835 Q-loop/lid; other site 655816003836 ABC transporter signature motif; other site 655816003837 Walker B; other site 655816003838 D-loop; other site 655816003839 H-loop/switch region; other site 655816003840 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 655816003841 YKOF-related Family; Region: Ykof; pfam07615 655816003842 YKOF-related Family; Region: Ykof; pfam07615 655816003843 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 655816003844 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816003845 active site 655816003846 phosphorylation site [posttranslational modification] 655816003847 intermolecular recognition site; other site 655816003848 dimerization interface [polypeptide binding]; other site 655816003849 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655816003850 DNA binding site [nucleotide binding] 655816003851 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 655816003852 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 655816003853 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655816003854 dimer interface [polypeptide binding]; other site 655816003855 phosphorylation site [posttranslational modification] 655816003856 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816003857 ATP binding site [chemical binding]; other site 655816003858 Mg2+ binding site [ion binding]; other site 655816003859 G-X-G motif; other site 655816003860 Predicted membrane protein [Function unknown]; Region: COG3212 655816003861 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 655816003862 Predicted membrane protein [Function unknown]; Region: COG3212 655816003863 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 655816003864 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 655816003865 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 655816003866 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 655816003867 MgtE intracellular N domain; Region: MgtE_N; cl15244 655816003868 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 655816003869 Divalent cation transporter; Region: MgtE; cl00786 655816003870 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 655816003871 DNA binding residues [nucleotide binding] 655816003872 putative dimer interface [polypeptide binding]; other site 655816003873 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816003874 Helix-turn-helix domains; Region: HTH; cl00088 655816003875 Helix-turn-helix domains; Region: HTH; cl00088 655816003876 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 655816003877 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 655816003878 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 655816003879 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 655816003880 putative active site [active] 655816003881 putative metal binding site [ion binding]; other site 655816003882 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 655816003883 Ligand binding site; other site 655816003884 Putative Catalytic site; other site 655816003885 DXD motif; other site 655816003886 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 655816003887 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 655816003888 active site 655816003889 DNA binding site [nucleotide binding] 655816003890 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 655816003891 nucleotide binding site [chemical binding]; other site 655816003892 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 655816003893 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 655816003894 putative DNA binding site [nucleotide binding]; other site 655816003895 putative homodimer interface [polypeptide binding]; other site 655816003896 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 655816003897 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 655816003898 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 655816003899 PAS domain; Region: PAS_9; pfam13426 655816003900 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 655816003901 metal binding site [ion binding]; metal-binding site 655816003902 active site 655816003903 I-site; other site 655816003904 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 655816003905 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 655816003906 Integral membrane protein TerC family; Region: TerC; cl10468 655816003907 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 655816003908 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655816003909 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 655816003910 transcription termination factor Rho; Provisional; Region: PRK12678 655816003911 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 655816003912 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 655816003913 Peptidase family M48; Region: Peptidase_M48; cl12018 655816003914 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 655816003915 Cation transport protein; Region: TrkH; cl10514 655816003916 OpgC protein; Region: OpgC_C; cl00792 655816003917 Acyltransferase family; Region: Acyl_transf_3; pfam01757 655816003918 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 655816003919 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 655816003920 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 655816003921 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 655816003922 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 655816003923 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 655816003924 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 655816003925 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655816003926 dimer interface [polypeptide binding]; other site 655816003927 phosphorylation site [posttranslational modification] 655816003928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816003929 ATP binding site [chemical binding]; other site 655816003930 Mg2+ binding site [ion binding]; other site 655816003931 G-X-G motif; other site 655816003932 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 655816003933 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 655816003934 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 655816003935 DNA binding site [nucleotide binding] 655816003936 active site 655816003937 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 655816003938 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 655816003939 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 655816003940 Phosphotransferase enzyme family; Region: APH; pfam01636 655816003941 Predicted amidohydrolase [General function prediction only]; Region: COG0388 655816003942 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 655816003943 putative active site [active] 655816003944 catalytic triad [active] 655816003945 putative dimer interface [polypeptide binding]; other site 655816003946 transaminase; Reviewed; Region: PRK08068 655816003947 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655816003948 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816003949 homodimer interface [polypeptide binding]; other site 655816003950 catalytic residue [active] 655816003951 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: salvage_mtnW; TIGR03332 655816003952 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 655816003953 dimer interface [polypeptide binding]; other site 655816003954 active site 655816003955 catalytic residue [active] 655816003956 metal binding site [ion binding]; metal-binding site 655816003957 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 655816003958 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816003959 motif II; other site 655816003960 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 655816003961 intersubunit interface [polypeptide binding]; other site 655816003962 active site 655816003963 Zn2+ binding site [ion binding]; other site 655816003964 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 655816003965 Cupin domain; Region: Cupin_2; cl09118 655816003966 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 655816003967 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 655816003968 Cache domain; Region: Cache_1; pfam02743 655816003969 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 655816003970 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655816003971 dimer interface [polypeptide binding]; other site 655816003972 phosphorylation site [posttranslational modification] 655816003973 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816003974 ATP binding site [chemical binding]; other site 655816003975 Mg2+ binding site [ion binding]; other site 655816003976 G-X-G motif; other site 655816003977 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816003978 Helix-turn-helix domains; Region: HTH; cl00088 655816003979 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 655816003980 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 655816003981 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 655816003982 ligand binding site [chemical binding]; other site 655816003983 flagellar motor protein MotA; Validated; Region: PRK08124 655816003984 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 655816003985 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 655816003986 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816003987 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 655816003988 Walker A motif; other site 655816003989 ATP binding site [chemical binding]; other site 655816003990 Walker B motif; other site 655816003991 arginine finger; other site 655816003992 UvrB/uvrC motif; Region: UVR; pfam02151 655816003993 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816003994 Walker A motif; other site 655816003995 ATP binding site [chemical binding]; other site 655816003996 Walker B motif; other site 655816003997 arginine finger; other site 655816003998 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 655816003999 Uncharacterized membrane protein [Function unknown]; Region: COG3949 655816004000 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 655816004001 Ligand Binding Site [chemical binding]; other site 655816004002 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 655816004003 active site 655816004004 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 655816004005 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655816004006 FeS/SAM binding site; other site 655816004007 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 655816004008 Protein of unknown function (DUF3219); Region: DUF3219; pfam11514 655816004009 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 655816004010 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 655816004011 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 655816004012 MatE; Region: MatE; cl10513 655816004013 MatE; Region: MatE; cl10513 655816004014 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 655816004015 catalytic residues [active] 655816004016 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 655816004017 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 655816004018 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 655816004019 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 655816004020 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 655816004021 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 655816004022 active site 655816004023 Transcriptional regulators [Transcription]; Region: PurR; COG1609 655816004024 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655816004025 DNA binding site [nucleotide binding] 655816004026 domain linker motif; other site 655816004027 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 655816004028 putative dimerization interface [polypeptide binding]; other site 655816004029 putative ligand binding site [chemical binding]; other site 655816004030 CAT RNA binding domain; Region: CAT_RBD; cl03904 655816004031 PRD domain; Region: PRD; cl15445 655816004032 PRD domain; Region: PRD; cl15445 655816004033 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 655816004034 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 655816004035 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 655816004036 active site turn [active] 655816004037 phosphorylation site [posttranslational modification] 655816004038 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 655816004039 HPr interaction site; other site 655816004040 glycerol kinase (GK) interaction site [polypeptide binding]; other site 655816004041 active site 655816004042 phosphorylation site [posttranslational modification] 655816004043 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 655816004044 dimerization domain swap beta strand [polypeptide binding]; other site 655816004045 regulatory protein interface [polypeptide binding]; other site 655816004046 active site 655816004047 regulatory phosphorylation site [posttranslational modification]; other site 655816004048 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 655816004049 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 655816004050 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 655816004051 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 655816004052 Transcriptional regulator protein (SplA); Region: SplA; pfam11132 655816004053 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 655816004054 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655816004055 FeS/SAM binding site; other site 655816004056 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 655816004057 Cache domain; Region: Cache_1; pfam02743 655816004058 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 655816004059 dimerization interface [polypeptide binding]; other site 655816004060 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 655816004061 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 655816004062 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 655816004063 dimer interface [polypeptide binding]; other site 655816004064 putative CheW interface [polypeptide binding]; other site 655816004065 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 655816004066 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816004067 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 655816004068 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 655816004069 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 655816004070 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 655816004071 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 655816004072 putative active site [active] 655816004073 heme pocket [chemical binding]; other site 655816004074 PAS fold; Region: PAS; pfam00989 655816004075 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 655816004076 putative active site [active] 655816004077 heme pocket [chemical binding]; other site 655816004078 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 655816004079 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 655816004080 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655816004081 dimer interface [polypeptide binding]; other site 655816004082 phosphorylation site [posttranslational modification] 655816004083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816004084 ATP binding site [chemical binding]; other site 655816004085 Mg2+ binding site [ion binding]; other site 655816004086 G-X-G motif; other site 655816004087 aminotransferase A; Validated; Region: PRK07683 655816004088 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655816004089 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816004090 homodimer interface [polypeptide binding]; other site 655816004091 catalytic residue [active] 655816004092 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 655816004093 putative CheA interaction surface; other site 655816004094 Response regulator receiver domain; Region: Response_reg; pfam00072 655816004095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816004096 active site 655816004097 phosphorylation site [posttranslational modification] 655816004098 intermolecular recognition site; other site 655816004099 dimerization interface [polypeptide binding]; other site 655816004100 YkyB-like protein; Region: YkyB; pfam14177 655816004101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816004102 H+ Antiporter protein; Region: 2A0121; TIGR00900 655816004103 putative substrate translocation pore; other site 655816004104 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 655816004105 putative peptidoglycan binding site; other site 655816004106 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 655816004107 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 655816004108 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 655816004109 putative active site [active] 655816004110 putative metal binding site [ion binding]; other site 655816004111 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 655816004112 short chain dehydrogenase; Provisional; Region: PRK07677 655816004113 NAD(P) binding site [chemical binding]; other site 655816004114 substrate binding site [chemical binding]; other site 655816004115 homotetramer interface [polypeptide binding]; other site 655816004116 active site 655816004117 homodimer interface [polypeptide binding]; other site 655816004118 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 655816004119 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 655816004120 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 655816004121 Protein of unknown function (DUF458); Region: DUF458; cl00861 655816004122 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 655816004123 FOG: CBS domain [General function prediction only]; Region: COG0517 655816004124 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 655816004125 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655816004126 Helix-turn-helix domains; Region: HTH; cl00088 655816004127 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 655816004128 dimerization interface [polypeptide binding]; other site 655816004129 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 655816004130 BNR repeat-like domain; Region: BNR_2; pfam13088 655816004131 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 655816004132 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 655816004133 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 655816004134 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 655816004135 active site 655816004136 trimer interface [polypeptide binding]; other site 655816004137 substrate binding site [chemical binding]; other site 655816004138 CoA binding site [chemical binding]; other site 655816004139 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 655816004140 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 655816004141 metal binding site [ion binding]; metal-binding site 655816004142 putative dimer interface [polypeptide binding]; other site 655816004143 Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214 655816004144 Mechanosensitive ion channel; Region: MS_channel; pfam00924 655816004145 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 655816004146 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 655816004147 dimer interface [polypeptide binding]; other site 655816004148 decamer (pentamer of dimers) interface [polypeptide binding]; other site 655816004149 catalytic triad [active] 655816004150 peroxidatic and resolving cysteines [active] 655816004151 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 655816004152 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 655816004153 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 655816004154 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 655816004155 GTP binding site; other site 655816004156 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 655816004157 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 655816004158 ATP binding site [chemical binding]; other site 655816004159 substrate interface [chemical binding]; other site 655816004160 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 655816004161 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 655816004162 dimer interface [polypeptide binding]; other site 655816004163 putative functional site; other site 655816004164 putative MPT binding site; other site 655816004165 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 655816004166 Walker A motif; other site 655816004167 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 655816004168 MoaE homodimer interface [polypeptide binding]; other site 655816004169 MoaD interaction [polypeptide binding]; other site 655816004170 active site residues [active] 655816004171 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 655816004172 MoaE interaction surface [polypeptide binding]; other site 655816004173 MoeB interaction surface [polypeptide binding]; other site 655816004174 thiocarboxylated glycine; other site 655816004175 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 655816004176 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 655816004177 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 655816004178 Walker A/P-loop; other site 655816004179 ATP binding site [chemical binding]; other site 655816004180 Q-loop/lid; other site 655816004181 ABC transporter signature motif; other site 655816004182 Walker B; other site 655816004183 D-loop; other site 655816004184 H-loop/switch region; other site 655816004185 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 655816004186 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 655816004187 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 655816004188 Walker A/P-loop; other site 655816004189 ATP binding site [chemical binding]; other site 655816004190 Q-loop/lid; other site 655816004191 ABC transporter signature motif; other site 655816004192 Walker B; other site 655816004193 D-loop; other site 655816004194 H-loop/switch region; other site 655816004195 Yip1 domain; Region: Yip1; cl12048 655816004196 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 655816004197 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 655816004198 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 655816004199 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 655816004200 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 655816004201 Walker A/P-loop; other site 655816004202 ATP binding site [chemical binding]; other site 655816004203 Q-loop/lid; other site 655816004204 ABC transporter signature motif; other site 655816004205 Walker B; other site 655816004206 D-loop; other site 655816004207 H-loop/switch region; other site 655816004208 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 655816004209 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 655816004210 FtsX-like permease family; Region: FtsX; cl15850 655816004211 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 655816004212 Helix-turn-helix domains; Region: HTH; cl00088 655816004213 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 655816004214 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 655816004215 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 655816004216 putative substrate binding site [chemical binding]; other site 655816004217 putative ATP binding site [chemical binding]; other site 655816004218 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 655816004219 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 655816004220 active site 655816004221 phosphorylation site [posttranslational modification] 655816004222 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 655816004223 P-loop; other site 655816004224 active site 655816004225 phosphorylation site [posttranslational modification] 655816004226 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 655816004227 Helix-turn-helix domains; Region: HTH; cl00088 655816004228 putative transposase OrfB; Reviewed; Region: PHA02517 655816004229 HTH-like domain; Region: HTH_21; pfam13276 655816004230 Integrase core domain; Region: rve; cl01316 655816004231 Integrase core domain; Region: rve_3; cl15866 655816004232 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 655816004233 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 655816004234 Catalytic site [active] 655816004235 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 655816004236 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 655816004237 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 655816004238 ABC transporter; Region: ABC_tran_2; pfam12848 655816004239 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 655816004240 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 655816004241 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816004242 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 655816004243 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 655816004244 rod-share determining protein MreBH; Provisional; Region: PRK13929 655816004245 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 655816004246 ATP binding site [chemical binding]; other site 655816004247 profilin binding site; other site 655816004248 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 655816004249 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 655816004250 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 655816004251 putative active site [active] 655816004252 heme pocket [chemical binding]; other site 655816004253 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655816004254 dimer interface [polypeptide binding]; other site 655816004255 phosphorylation site [posttranslational modification] 655816004256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816004257 ATP binding site [chemical binding]; other site 655816004258 Mg2+ binding site [ion binding]; other site 655816004259 G-X-G motif; other site 655816004260 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 655816004261 putative active site pocket [active] 655816004262 dimerization interface [polypeptide binding]; other site 655816004263 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 655816004264 putative active site pocket [active] 655816004265 dimerization interface [polypeptide binding]; other site 655816004266 putative catalytic residue [active] 655816004267 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 655816004268 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816004269 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 655816004270 adenine deaminase; Region: ade; TIGR01178 655816004271 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 655816004272 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 655816004273 active site 655816004274 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 655816004275 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 655816004276 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 655816004277 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 655816004278 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 655816004279 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816004280 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 655816004281 active site 655816004282 motif I; other site 655816004283 motif II; other site 655816004284 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 655816004285 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 655816004286 active site 655816004287 catalytic residues [active] 655816004288 metal binding site [ion binding]; metal-binding site 655816004289 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 655816004290 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 655816004291 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 655816004292 TPP-binding site [chemical binding]; other site 655816004293 tetramer interface [polypeptide binding]; other site 655816004294 heterodimer interface [polypeptide binding]; other site 655816004295 phosphorylation loop region [posttranslational modification] 655816004296 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 655816004297 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 655816004298 alpha subunit interface [polypeptide binding]; other site 655816004299 TPP binding site [chemical binding]; other site 655816004300 heterodimer interface [polypeptide binding]; other site 655816004301 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 655816004302 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 655816004303 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 655816004304 E3 interaction surface; other site 655816004305 lipoyl attachment site [posttranslational modification]; other site 655816004306 e3 binding domain; Region: E3_binding; pfam02817 655816004307 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 655816004308 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 655816004309 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816004310 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655816004311 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 655816004312 Helix-turn-helix domains; Region: HTH; cl00088 655816004313 putative transposase OrfB; Reviewed; Region: PHA02517 655816004314 HTH-like domain; Region: HTH_21; pfam13276 655816004315 Integrase core domain; Region: rve; cl01316 655816004316 Integrase core domain; Region: rve_3; cl15866 655816004317 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 655816004318 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 655816004319 homodimer interface [polypeptide binding]; other site 655816004320 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816004321 catalytic residue [active] 655816004322 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 655816004323 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 655816004324 Protein of unknown function (DUF1054); Region: DUF1054; cl11544 655816004325 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 655816004326 active site 655816004327 Leucine carboxyl methyltransferase; Region: LCM; cl01306 655816004328 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 655816004329 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 655816004330 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 655816004331 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 655816004332 active site 655816004333 Zn binding site [ion binding]; other site 655816004334 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655816004335 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 655816004336 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655816004337 DNA binding residues [nucleotide binding] 655816004338 Predicted integral membrane protein [Function unknown]; Region: COG5660 655816004339 Putative zinc-finger; Region: zf-HC2; cl15806 655816004340 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 655816004341 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 655816004342 G1 box; other site 655816004343 putative GEF interaction site [polypeptide binding]; other site 655816004344 GTP/Mg2+ binding site [chemical binding]; other site 655816004345 Switch I region; other site 655816004346 G2 box; other site 655816004347 G3 box; other site 655816004348 Switch II region; other site 655816004349 G4 box; other site 655816004350 G5 box; other site 655816004351 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 655816004352 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 655816004353 YlaH-like protein; Region: YlaH; pfam14036 655816004354 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; cl11558 655816004355 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 655816004356 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 655816004357 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 655816004358 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 655816004359 putative active site [active] 655816004360 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816004361 Glutaminase; Region: Glutaminase; cl00907 655816004362 Protein of unknown function (DUF1507); Region: DUF1507; cl11487 655816004363 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 655816004364 pyruvate carboxylase; Reviewed; Region: PRK12999 655816004365 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 655816004366 ATP-grasp domain; Region: ATP-grasp_4; cl03087 655816004367 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 655816004368 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 655816004369 active site 655816004370 catalytic residues [active] 655816004371 metal binding site [ion binding]; metal-binding site 655816004372 homodimer binding site [polypeptide binding]; other site 655816004373 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 655816004374 carboxyltransferase (CT) interaction site; other site 655816004375 biotinylation site [posttranslational modification]; other site 655816004376 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 655816004377 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 655816004378 UbiA prenyltransferase family; Region: UbiA; cl00337 655816004379 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 655816004380 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 655816004381 Cytochrome c; Region: Cytochrom_C; cl11414 655816004382 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 655816004383 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 655816004384 D-pathway; other site 655816004385 Putative ubiquinol binding site [chemical binding]; other site 655816004386 Low-spin heme (heme b) binding site [chemical binding]; other site 655816004387 Putative water exit pathway; other site 655816004388 Binuclear center (heme o3/CuB) [ion binding]; other site 655816004389 K-pathway; other site 655816004390 Putative proton exit pathway; other site 655816004391 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 655816004392 Subunit I/III interface [polypeptide binding]; other site 655816004393 Subunit III/IV interface [polypeptide binding]; other site 655816004394 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 655816004395 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 655816004396 YugN-like family; Region: YugN; pfam08868 655816004397 FOG: CBS domain [General function prediction only]; Region: COG0517 655816004398 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 655816004399 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 655816004400 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 655816004401 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 655816004402 Putative coat protein; Region: YlbD_coat; pfam14071 655816004403 YlbE-like protein; Region: YlbE; pfam14003 655816004404 Protein of unknown function (DUF964); Region: DUF964; cl01483 655816004405 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 655816004406 ylbH leader; regulatory RNA structure (riboswitch) potentially involved in regulation of ylbH; BSUW23_misc_RNA_23 655816004407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816004408 S-adenosylmethionine binding site [chemical binding]; other site 655816004409 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 655816004410 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 655816004411 active site 655816004412 (T/H)XGH motif; other site 655816004413 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 655816004414 Nucleoside recognition; Region: Gate; cl00486 655816004415 Nucleoside recognition; Region: Gate; cl00486 655816004416 hypothetical protein; Provisional; Region: PRK10279 655816004417 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 655816004418 nucleophile elbow; other site 655816004419 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 655816004420 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 655816004421 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 655816004422 protein binding site [polypeptide binding]; other site 655816004423 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 655816004424 hypothetical protein; Provisional; Region: PRK13670 655816004425 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 655816004426 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 655816004427 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 655816004428 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 655816004429 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 655816004430 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816004431 Coenzyme A binding pocket [chemical binding]; other site 655816004432 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 655816004433 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816004434 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 655816004435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 655816004436 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 655816004437 mraZ protein; Region: TIGR00242 655816004438 MraZ protein; Region: MraZ; pfam02381 655816004439 MraZ protein; Region: MraZ; pfam02381 655816004440 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 655816004441 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816004442 Septum formation initiator; Region: DivIC; cl11433 655816004443 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 655816004444 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 655816004445 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 655816004446 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 655816004447 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 655816004448 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 655816004449 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 655816004450 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 655816004451 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 655816004452 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 655816004453 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 655816004454 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 655816004455 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 655816004456 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 655816004457 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 655816004458 Mg++ binding site [ion binding]; other site 655816004459 putative catalytic motif [active] 655816004460 putative substrate binding site [chemical binding]; other site 655816004461 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 655816004462 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 655816004463 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 655816004464 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 655816004465 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 655816004466 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 655816004467 active site 655816004468 homodimer interface [polypeptide binding]; other site 655816004469 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 655816004470 FAD binding domain; Region: FAD_binding_4; pfam01565 655816004471 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 655816004472 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 655816004473 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 655816004474 Cell division protein FtsQ; Region: FtsQ; pfam03799 655816004475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 655816004476 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 655816004477 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 655816004478 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 655816004479 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 655816004480 cell division protein FtsA; Region: ftsA; TIGR01174 655816004481 Cell division protein FtsA; Region: FtsA; cl11496 655816004482 Cell division protein FtsA; Region: FtsA; cl11496 655816004483 cell division protein FtsZ; Validated; Region: PRK09330 655816004484 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 655816004485 nucleotide binding site [chemical binding]; other site 655816004486 SulA interaction site; other site 655816004487 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 655816004488 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 655816004489 active site 655816004490 catalytic triad [active] 655816004491 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 655816004492 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 655816004493 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 655816004494 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 655816004495 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 655816004496 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 655816004497 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 655816004498 sporulation sigma factor SigE; Reviewed; Region: PRK08301 655816004499 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655816004500 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655816004501 DNA binding residues [nucleotide binding] 655816004502 sporulation sigma factor SigG; Reviewed; Region: PRK08215 655816004503 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655816004504 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 655816004505 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655816004506 DNA binding residues [nucleotide binding] 655816004507 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 655816004508 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 655816004509 Walker A/P-loop; other site 655816004510 ATP binding site [chemical binding]; other site 655816004511 Q-loop/lid; other site 655816004512 ABC transporter signature motif; other site 655816004513 Walker B; other site 655816004514 D-loop; other site 655816004515 H-loop/switch region; other site 655816004516 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 655816004517 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 655816004518 metal binding site [ion binding]; metal-binding site 655816004519 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 655816004520 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 655816004521 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 655816004522 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 655816004523 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 655816004524 catalytic residue [active] 655816004525 Protein of unknown function (DUF552); Region: DUF552; cl00775 655816004526 YGGT family; Region: YGGT; cl00508 655816004527 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 655816004528 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 655816004529 RNA binding surface [nucleotide binding]; other site 655816004530 DivIVA protein; Region: DivIVA; pfam05103 655816004531 DivIVA domain; Region: DivI1A_domain; TIGR03544 655816004532 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 655816004533 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 655816004534 HIGH motif; other site 655816004535 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 655816004536 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 655816004537 active site 655816004538 KMSKS motif; other site 655816004539 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 655816004540 tRNA binding surface [nucleotide binding]; other site 655816004541 anticodon binding site; other site 655816004542 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 655816004543 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 655816004544 lipoprotein signal peptidase; Provisional; Region: PRK14787 655816004545 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 655816004546 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 655816004547 RNA binding surface [nucleotide binding]; other site 655816004548 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 655816004549 active site 655816004550 pyrR leader; transcriptional attenuator structure and binding site for PyrR regulator; BSUW23_misc_RNA_26 655816004551 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 655816004552 active site 655816004553 pyrP leader; transcriptional attenuator structure and binding site for PyrR regulator; BSUW23_misc_RNA_27 655816004554 uracil-xanthine permease; Region: ncs2; TIGR00801 655816004555 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 655816004556 pyrB leader; transcriptional attenuator structure and binding site for PyrR regulator; BSUW23_misc_RNA_28 655816004557 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 655816004558 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 655816004559 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816004560 dihydroorotase; Validated; Region: pyrC; PRK09357 655816004561 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 655816004562 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 655816004563 active site 655816004564 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 655816004565 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 655816004566 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 655816004567 catalytic site [active] 655816004568 subunit interface [polypeptide binding]; other site 655816004569 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 655816004570 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 655816004571 ATP-grasp domain; Region: ATP-grasp_4; cl03087 655816004572 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 655816004573 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 655816004574 ATP-grasp domain; Region: ATP-grasp_4; cl03087 655816004575 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 655816004576 IMP binding site; other site 655816004577 dimer interface [polypeptide binding]; other site 655816004578 interdomain contacts; other site 655816004579 partial ornithine binding site; other site 655816004580 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 655816004581 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 655816004582 FAD binding pocket [chemical binding]; other site 655816004583 FAD binding motif [chemical binding]; other site 655816004584 phosphate binding motif [ion binding]; other site 655816004585 beta-alpha-beta structure motif; other site 655816004586 NAD binding pocket [chemical binding]; other site 655816004587 Iron coordination center [ion binding]; other site 655816004588 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 655816004589 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 655816004590 heterodimer interface [polypeptide binding]; other site 655816004591 active site 655816004592 FMN binding site [chemical binding]; other site 655816004593 homodimer interface [polypeptide binding]; other site 655816004594 substrate binding site [chemical binding]; other site 655816004595 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 655816004596 active site 655816004597 dimer interface [polypeptide binding]; other site 655816004598 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 655816004599 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 655816004600 active site 655816004601 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 655816004602 Active Sites [active] 655816004603 Phosphate transporter family; Region: PHO4; cl00396 655816004604 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 655816004605 ATP-sulfurylase; Region: ATPS; cd00517 655816004606 active site 655816004607 HXXH motif; other site 655816004608 flexible loop; other site 655816004609 AAA domain; Region: AAA_33; pfam13671 655816004610 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 655816004611 ligand-binding site [chemical binding]; other site 655816004612 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 655816004613 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 655816004614 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 655816004615 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 655816004616 putative active site [active] 655816004617 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 655816004618 putative active site [active] 655816004619 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816004620 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 655816004621 Domain of unknown function (DUF814); Region: DUF814; pfam05670 655816004622 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 655816004623 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 655816004624 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 655816004625 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 655816004626 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816004627 motif II; other site 655816004628 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 655816004629 TIGR00255 family protein; Region: TIGR00255 655816004630 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 655816004631 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 655816004632 Domain of unknown function (DUF370); Region: DUF370; cl00898 655816004633 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 655816004634 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 655816004635 catalytic site [active] 655816004636 G-X2-G-X-G-K; other site 655816004637 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 655816004638 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 655816004639 Flavoprotein; Region: Flavoprotein; cl08021 655816004640 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 655816004641 primosome assembly protein PriA; Validated; Region: PRK05580 655816004642 primosome assembly protein PriA; Validated; Region: PRK05580 655816004643 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 655816004644 ATP binding site [chemical binding]; other site 655816004645 putative Mg++ binding site [ion binding]; other site 655816004646 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655816004647 nucleotide binding region [chemical binding]; other site 655816004648 ATP-binding site [chemical binding]; other site 655816004649 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 655816004650 active site 655816004651 catalytic residues [active] 655816004652 metal binding site [ion binding]; metal-binding site 655816004653 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 655816004654 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 655816004655 putative active site [active] 655816004656 substrate binding site [chemical binding]; other site 655816004657 putative cosubstrate binding site; other site 655816004658 catalytic site [active] 655816004659 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 655816004660 substrate binding site [chemical binding]; other site 655816004661 16S rRNA methyltransferase B; Provisional; Region: PRK14902 655816004662 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 655816004663 putative RNA binding site [nucleotide binding]; other site 655816004664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816004665 S-adenosylmethionine binding site [chemical binding]; other site 655816004666 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 655816004667 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655816004668 FeS/SAM binding site; other site 655816004669 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 655816004670 Protein phosphatase 2C; Region: PP2C; pfam00481 655816004671 active site 655816004672 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 655816004673 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 655816004674 active site 655816004675 ATP binding site [chemical binding]; other site 655816004676 substrate binding site [chemical binding]; other site 655816004677 activation loop (A-loop); other site 655816004678 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 655816004679 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 655816004680 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 655816004681 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 655816004682 GTPase RsgA; Reviewed; Region: PRK00098 655816004683 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 655816004684 RNA binding site [nucleotide binding]; other site 655816004685 homodimer interface [polypeptide binding]; other site 655816004686 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 655816004687 GTPase/Zn-binding domain interface [polypeptide binding]; other site 655816004688 GTP/Mg2+ binding site [chemical binding]; other site 655816004689 G4 box; other site 655816004690 G5 box; other site 655816004691 G1 box; other site 655816004692 Switch I region; other site 655816004693 G2 box; other site 655816004694 G3 box; other site 655816004695 Switch II region; other site 655816004696 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 655816004697 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 655816004698 substrate binding site [chemical binding]; other site 655816004699 hexamer interface [polypeptide binding]; other site 655816004700 metal binding site [ion binding]; metal-binding site 655816004701 Thiamine pyrophosphokinase; Region: TPK; cd07995 655816004702 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 655816004703 active site 655816004704 dimerization interface [polypeptide binding]; other site 655816004705 thiamine binding site [chemical binding]; other site 655816004706 Stage V sporulation protein family; Region: SpoV; cl15455 655816004707 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 655816004708 Asp23 family; Region: Asp23; cl00574 655816004709 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 655816004710 DAK2 domain; Region: Dak2; cl03685 655816004711 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 655816004712 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 655816004713 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 655816004714 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 655816004715 putative L-serine binding site [chemical binding]; other site 655816004716 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 655816004717 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 655816004718 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 655816004719 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 655816004720 generic binding surface II; other site 655816004721 ssDNA binding site; other site 655816004722 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 655816004723 ATP binding site [chemical binding]; other site 655816004724 putative Mg++ binding site [ion binding]; other site 655816004725 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655816004726 nucleotide binding region [chemical binding]; other site 655816004727 ATP-binding site [chemical binding]; other site 655816004728 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 655816004729 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 655816004730 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 655816004731 Acyl transferase domain; Region: Acyl_transf_1; cl08282 655816004732 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 655816004733 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 655816004734 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 655816004735 NAD(P) binding site [chemical binding]; other site 655816004736 homotetramer interface [polypeptide binding]; other site 655816004737 homodimer interface [polypeptide binding]; other site 655816004738 active site 655816004739 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816004740 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 655816004741 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 655816004742 dimerization interface [polypeptide binding]; other site 655816004743 active site 655816004744 metal binding site [ion binding]; metal-binding site 655816004745 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 655816004746 dsRNA binding site [nucleotide binding]; other site 655816004747 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 655816004748 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 655816004749 Walker A/P-loop; other site 655816004750 ATP binding site [chemical binding]; other site 655816004751 Q-loop/lid; other site 655816004752 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 655816004753 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 655816004754 ABC transporter signature motif; other site 655816004755 Walker B; other site 655816004756 D-loop; other site 655816004757 H-loop/switch region; other site 655816004758 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 655816004759 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 655816004760 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 655816004761 GTP binding site [chemical binding]; other site 655816004762 Helix-turn-helix domains; Region: HTH; cl00088 655816004763 putative transposase OrfB; Reviewed; Region: PHA02517 655816004764 HTH-like domain; Region: HTH_21; pfam13276 655816004765 Integrase core domain; Region: rve; cl01316 655816004766 Integrase core domain; Region: rve_3; cl15866 655816004767 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 655816004768 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 655816004769 signal recognition particle protein; Provisional; Region: PRK10867 655816004770 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 655816004771 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 655816004772 P loop; other site 655816004773 GTP binding site [chemical binding]; other site 655816004774 Signal peptide binding domain; Region: SRP_SPB; pfam02978 655816004775 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 655816004776 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 655816004777 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 655816004778 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 655816004779 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 655816004780 RimM N-terminal domain; Region: RimM; pfam01782 655816004781 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 655816004782 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 655816004783 L19 leader; ribosomal protein gene, untranslated leader; autoregulatory structure; BSUW23_misc_RNA_30 655816004784 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 655816004785 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 655816004786 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 655816004787 GTP/Mg2+ binding site [chemical binding]; other site 655816004788 G4 box; other site 655816004789 G5 box; other site 655816004790 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 655816004791 G1 box; other site 655816004792 G1 box; other site 655816004793 GTP/Mg2+ binding site [chemical binding]; other site 655816004794 Switch I region; other site 655816004795 G2 box; other site 655816004796 G2 box; other site 655816004797 G3 box; other site 655816004798 G3 box; other site 655816004799 Switch II region; other site 655816004800 Switch II region; other site 655816004801 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 655816004802 RNA/DNA hybrid binding site [nucleotide binding]; other site 655816004803 active site 655816004804 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 655816004805 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 655816004806 ATP-grasp domain; Region: ATP-grasp_4; cl03087 655816004807 CoA-ligase; Region: Ligase_CoA; cl02894 655816004808 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 655816004809 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816004810 CoA-ligase; Region: Ligase_CoA; cl02894 655816004811 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 655816004812 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 655816004813 DNA topoisomerase I; Validated; Region: PRK05582 655816004814 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 655816004815 active site 655816004816 interdomain interaction site; other site 655816004817 putative metal-binding site [ion binding]; other site 655816004818 nucleotide binding site [chemical binding]; other site 655816004819 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 655816004820 domain I; other site 655816004821 DNA binding groove [nucleotide binding] 655816004822 phosphate binding site [ion binding]; other site 655816004823 domain II; other site 655816004824 domain III; other site 655816004825 nucleotide binding site [chemical binding]; other site 655816004826 catalytic site [active] 655816004827 domain IV; other site 655816004828 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 655816004829 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 655816004830 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 655816004831 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816004832 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 655816004833 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 655816004834 Int/Topo IB signature motif; other site 655816004835 active site 655816004836 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 655816004837 active site 655816004838 HslU subunit interaction site [polypeptide binding]; other site 655816004839 sequence realted to clpY is present, but appears to have been inactivated by a small internal deletion causing a frameshift 655816004840 transcriptional repressor CodY; Validated; Region: PRK04158 655816004841 CodY GAF-like domain; Region: CodY; pfam06018 655816004842 Helix-turn-helix domains; Region: HTH; cl00088 655816004843 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 655816004844 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 655816004845 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 655816004846 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 655816004847 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 655816004848 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 655816004849 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 655816004850 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 655816004851 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 655816004852 flagellar motor switch protein FliG; Region: fliG; TIGR00207 655816004853 MgtE intracellular N domain; Region: MgtE_N; cl15244 655816004854 FliG C-terminal domain; Region: FliG_C; pfam01706 655816004855 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 655816004856 Plant ATP synthase F0; Region: YMF19; cl07975 655816004857 Flagellar assembly protein FliH; Region: FliH; pfam02108 655816004858 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 655816004859 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 655816004860 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 655816004861 Walker A motif/ATP binding site; other site 655816004862 Walker B motif; other site 655816004863 flagellar biosynthesis chaperone; Validated; Region: fliJ; cl09161 655816004864 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 655816004865 MgtE intracellular N domain; Region: MgtE_N; cl15244 655816004866 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 655816004867 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 655816004868 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 655816004869 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 655816004870 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 655816004871 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 655816004872 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 655816004873 Flagellar protein (FlbD); Region: FlbD; cl00683 655816004874 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 655816004875 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 655816004876 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 655816004877 flagellar motor switch protein; Validated; Region: PRK08119 655816004878 Chemotaxis phosphatase CheX; Region: CheX; cl15816 655816004879 Chemotaxis phosphatase CheX; Region: CheX; cl15816 655816004880 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 655816004881 Response regulator receiver domain; Region: Response_reg; pfam00072 655816004882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816004883 active site 655816004884 phosphorylation site [posttranslational modification] 655816004885 intermolecular recognition site; other site 655816004886 dimerization interface [polypeptide binding]; other site 655816004887 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 655816004888 FliP family; Region: FliP; cl00593 655816004889 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 655816004890 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 655816004891 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 655816004892 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 655816004893 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 655816004894 FHIPEP family; Region: FHIPEP; pfam00771 655816004895 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 655816004896 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816004897 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 655816004898 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 655816004899 P-loop; other site 655816004900 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 655816004901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816004902 active site 655816004903 phosphorylation site [posttranslational modification] 655816004904 intermolecular recognition site; other site 655816004905 dimerization interface [polypeptide binding]; other site 655816004906 CheB methylesterase; Region: CheB_methylest; pfam01339 655816004907 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 655816004908 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 655816004909 putative binding surface; other site 655816004910 active site 655816004911 P2 response regulator binding domain; Region: P2; pfam07194 655816004912 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 655816004913 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816004914 ATP binding site [chemical binding]; other site 655816004915 Mg2+ binding site [ion binding]; other site 655816004916 G-X-G motif; other site 655816004917 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 655816004918 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 655816004919 putative CheA interaction surface; other site 655816004920 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 655816004921 Chemotaxis phosphatase CheX; Region: CheX; cl15816 655816004922 Chemotaxis phosphatase CheX; Region: CheX; cl15816 655816004923 CheD chemotactic sensory transduction; Region: CheD; cl00810 655816004924 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 655816004925 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655816004926 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 655816004927 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655816004928 DNA binding residues [nucleotide binding] 655816004929 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 655816004930 rRNA interaction site [nucleotide binding]; other site 655816004931 S8 interaction site; other site 655816004932 putative laminin-1 binding site; other site 655816004933 elongation factor Ts; Provisional; Region: tsf; PRK09377 655816004934 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 655816004935 Elongation factor TS; Region: EF_TS; pfam00889 655816004936 Elongation factor TS; Region: EF_TS; pfam00889 655816004937 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 655816004938 putative nucleotide binding site [chemical binding]; other site 655816004939 uridine monophosphate binding site [chemical binding]; other site 655816004940 homohexameric interface [polypeptide binding]; other site 655816004941 ribosome recycling factor; Reviewed; Region: frr; PRK00083 655816004942 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 655816004943 hinge region; other site 655816004944 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 655816004945 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 655816004946 catalytic residue [active] 655816004947 putative FPP diphosphate binding site; other site 655816004948 putative FPP binding hydrophobic cleft; other site 655816004949 dimer interface [polypeptide binding]; other site 655816004950 putative IPP diphosphate binding site; other site 655816004951 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 655816004952 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 655816004953 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 655816004954 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 655816004955 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 655816004956 RIP metalloprotease RseP; Region: TIGR00054 655816004957 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 655816004958 active site 655816004959 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 655816004960 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 655816004961 protein binding site [polypeptide binding]; other site 655816004962 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 655816004963 putative substrate binding region [chemical binding]; other site 655816004964 prolyl-tRNA synthetase; Provisional; Region: PRK09194 655816004965 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 655816004966 dimer interface [polypeptide binding]; other site 655816004967 motif 1; other site 655816004968 active site 655816004969 motif 2; other site 655816004970 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 655816004971 putative deacylase active site [active] 655816004972 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 655816004973 active site 655816004974 motif 3; other site 655816004975 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 655816004976 anticodon binding site; other site 655816004977 DNA polymerase III PolC; Validated; Region: polC; PRK00448 655816004978 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 655816004979 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 655816004980 generic binding surface II; other site 655816004981 generic binding surface I; other site 655816004982 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 655816004983 active site 655816004984 substrate binding site [chemical binding]; other site 655816004985 catalytic site [active] 655816004986 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 655816004987 ribosome maturation protein RimP; Reviewed; Region: PRK00092 655816004988 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 655816004989 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 655816004990 Sm1 motif; other site 655816004991 predicted subunit interaction site [polypeptide binding]; other site 655816004992 RNA binding pocket [nucleotide binding]; other site 655816004993 Sm2 motif; other site 655816004994 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 655816004995 NusA N-terminal domain; Region: NusA_N; pfam08529 655816004996 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 655816004997 RNA binding site [nucleotide binding]; other site 655816004998 homodimer interface [polypeptide binding]; other site 655816004999 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 655816005000 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 655816005001 G-X-X-G motif; other site 655816005002 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 655816005003 putative RNA binding cleft [nucleotide binding]; other site 655816005004 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 655816005005 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 655816005006 translation initiation factor IF-2; Region: IF-2; TIGR00487 655816005007 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 655816005008 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 655816005009 G1 box; other site 655816005010 putative GEF interaction site [polypeptide binding]; other site 655816005011 GTP/Mg2+ binding site [chemical binding]; other site 655816005012 Switch I region; other site 655816005013 G2 box; other site 655816005014 G3 box; other site 655816005015 Switch II region; other site 655816005016 G4 box; other site 655816005017 G5 box; other site 655816005018 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 655816005019 Translation-initiation factor 2; Region: IF-2; pfam11987 655816005020 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 655816005021 Protein of unknown function (DUF503); Region: DUF503; cl00669 655816005022 Ribosome-binding factor A; Region: RBFA; cl00542 655816005023 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 655816005024 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 655816005025 RNA binding site [nucleotide binding]; other site 655816005026 active site 655816005027 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 655816005028 riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083 655816005029 active site 655816005030 Riboflavin kinase; Region: Flavokinase; cl03312 655816005031 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 655816005032 16S/18S rRNA binding site [nucleotide binding]; other site 655816005033 S13e-L30e interaction site [polypeptide binding]; other site 655816005034 25S rRNA binding site [nucleotide binding]; other site 655816005035 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 655816005036 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 655816005037 RNase E interface [polypeptide binding]; other site 655816005038 trimer interface [polypeptide binding]; other site 655816005039 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 655816005040 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 655816005041 RNase E interface [polypeptide binding]; other site 655816005042 trimer interface [polypeptide binding]; other site 655816005043 active site 655816005044 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 655816005045 putative nucleic acid binding region [nucleotide binding]; other site 655816005046 G-X-X-G motif; other site 655816005047 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 655816005048 RNA binding site [nucleotide binding]; other site 655816005049 domain interface; other site 655816005050 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 655816005051 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 655816005052 NodB motif; other site 655816005053 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 655816005054 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 655816005055 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 655816005056 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 655816005057 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 655816005058 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816005059 Flavoprotein; Region: Flavoprotein; cl08021 655816005060 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 655816005061 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816005062 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 655816005063 aspartate kinase I; Reviewed; Region: PRK08210 655816005064 AAK_AKi-DapG-BS: Amino Acid Kinase Superfamily (AAK), AKi-DapG; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional class enzyme found in Bacilli; Region: AAK_AKi-DapG-BS; cd04260 655816005065 putative catalytic residues [active] 655816005066 putative nucleotide binding site [chemical binding]; other site 655816005067 putative aspartate binding site [chemical binding]; other site 655816005068 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 655816005069 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 655816005070 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 655816005071 dihydrodipicolinate synthase; Region: dapA; TIGR00674 655816005072 dimer interface [polypeptide binding]; other site 655816005073 active site 655816005074 catalytic residue [active] 655816005075 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 655816005076 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 655816005077 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 655816005078 Clp protease; Region: CLP_protease; pfam00574 655816005079 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 655816005080 active site 655816005081 YlzJ-like protein; Region: YlzJ; pfam14035 655816005082 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 655816005083 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 655816005084 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816005085 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 655816005086 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 655816005087 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816005088 DNA-binding site [nucleotide binding]; DNA binding site 655816005089 UTRA domain; Region: UTRA; cl01230 655816005090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816005091 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816005092 putative substrate translocation pore; other site 655816005093 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 655816005094 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 655816005095 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 655816005096 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 655816005097 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 655816005098 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 655816005099 classical (c) SDRs; Region: SDR_c; cd05233 655816005100 NAD(P) binding site [chemical binding]; other site 655816005101 active site 655816005102 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 655816005103 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 655816005104 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 655816005105 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 655816005106 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 655816005107 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 655816005108 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 655816005109 competence damage-inducible protein A; Provisional; Region: PRK00549 655816005110 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 655816005111 putative MPT binding site; other site 655816005112 Competence-damaged protein; Region: CinA; cl00666 655816005113 recombinase A; Provisional; Region: recA; PRK09354 655816005114 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 655816005115 hexamer interface [polypeptide binding]; other site 655816005116 Walker A motif; other site 655816005117 ATP binding site [chemical binding]; other site 655816005118 Walker B motif; other site 655816005119 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 655816005120 phosphodiesterase; Provisional; Region: PRK12704 655816005121 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 655816005122 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 655816005123 putative active site [active] 655816005124 metal binding site [ion binding]; metal-binding site 655816005125 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 655816005126 homodimer binding site [polypeptide binding]; other site 655816005127 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 655816005128 Threonine dehydrogenase; Region: TDH; cd05281 655816005129 L-threonine 3-dehydrogenase; Region: tdh; TIGR00692 655816005130 structural Zn binding site [ion binding]; other site 655816005131 catalytic Zn binding site [ion binding]; other site 655816005132 tetramer interface [polypeptide binding]; other site 655816005133 NADP binding site [chemical binding]; other site 655816005134 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 655816005135 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 655816005136 substrate-cofactor binding pocket; other site 655816005137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816005138 catalytic residue [active] 655816005139 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 655816005140 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 655816005141 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655816005142 FeS/SAM binding site; other site 655816005143 TRAM domain; Region: TRAM; cl01282 655816005144 Protein of unknown function (DUF964); Region: DUF964; cl01483 655816005145 Outer spore coat protein E (CotE); Region: CotE; pfam10628 655816005146 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 655816005147 MutS domain I; Region: MutS_I; pfam01624 655816005148 MutS domain II; Region: MutS_II; pfam05188 655816005149 MutS family domain IV; Region: MutS_IV; pfam05190 655816005150 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 655816005151 Walker A/P-loop; other site 655816005152 ATP binding site [chemical binding]; other site 655816005153 Q-loop/lid; other site 655816005154 ABC transporter signature motif; other site 655816005155 Walker B; other site 655816005156 D-loop; other site 655816005157 H-loop/switch region; other site 655816005158 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 655816005159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816005160 ATP binding site [chemical binding]; other site 655816005161 Mg2+ binding site [ion binding]; other site 655816005162 G-X-G motif; other site 655816005163 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 655816005164 ATP binding site [chemical binding]; other site 655816005165 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 655816005166 CAAX protease self-immunity; Region: Abi; cl00558 655816005167 Regulatory protein YrvL; Region: YrvL; pfam14184 655816005168 transcriptional regulator BetI; Validated; Region: PRK00767 655816005169 Helix-turn-helix domains; Region: HTH; cl00088 655816005170 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 655816005171 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 655816005172 Acyl transferase domain; Region: Acyl_transf_1; cl08282 655816005173 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 655816005174 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 655816005175 Acyl transferase domain; Region: Acyl_transf_1; cl08282 655816005176 Acyl transferase domain; Region: Acyl_transf_1; cl08282 655816005177 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 655816005178 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 655816005179 FMN binding site [chemical binding]; other site 655816005180 substrate binding site [chemical binding]; other site 655816005181 putative catalytic residue [active] 655816005182 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816005183 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 655816005184 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 655816005185 dimer interface [polypeptide binding]; other site 655816005186 active site 655816005187 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 655816005188 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827 655816005189 dimer interface [polypeptide binding]; other site 655816005190 active site 655816005191 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 655816005192 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 655816005193 substrate binding site [chemical binding]; other site 655816005194 oxyanion hole (OAH) forming residues; other site 655816005195 trimer interface [polypeptide binding]; other site 655816005196 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 655816005197 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 655816005198 substrate binding site [chemical binding]; other site 655816005199 oxyanion hole (OAH) forming residues; other site 655816005200 trimer interface [polypeptide binding]; other site 655816005201 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 655816005202 AMP-binding enzyme; Region: AMP-binding; cl15778 655816005203 AMP-binding enzyme; Region: AMP-binding; cl15778 655816005204 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816005205 Condensation domain; Region: Condensation; pfam00668 655816005206 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 655816005207 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 655816005208 AMP-binding enzyme; Region: AMP-binding; cl15778 655816005209 acyl-CoA synthetase; Validated; Region: PRK08308 655816005210 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816005211 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 655816005212 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655816005213 active site 655816005214 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 655816005215 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 655816005216 putative NADP binding site [chemical binding]; other site 655816005217 active site 655816005218 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816005219 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816005220 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 655816005221 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655816005222 active site 655816005223 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 655816005224 putative NADP binding site [chemical binding]; other site 655816005225 active site 655816005226 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816005227 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655816005228 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 655816005229 active site 655816005230 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 655816005231 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816005232 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655816005233 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 655816005234 active site 655816005235 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 655816005236 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 655816005237 putative NADP binding site [chemical binding]; other site 655816005238 active site 655816005239 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816005240 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 655816005241 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655816005242 active site 655816005243 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816005244 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816005245 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 655816005246 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655816005247 active site 655816005248 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 655816005249 putative NADP binding site [chemical binding]; other site 655816005250 active site 655816005251 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816005252 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655816005253 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 655816005254 active site 655816005255 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 655816005256 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816005257 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 655816005258 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655816005259 active site 655816005260 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 655816005261 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 655816005262 putative NADP binding site [chemical binding]; other site 655816005263 active site 655816005264 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816005265 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816005266 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816005267 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 655816005268 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655816005269 active site 655816005270 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 655816005271 putative NADP binding site [chemical binding]; other site 655816005272 active site 655816005273 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816005274 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655816005275 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 655816005276 active site 655816005277 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816005278 Condensation domain; Region: Condensation; pfam00668 655816005279 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 655816005280 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 655816005281 AMP-binding enzyme; Region: AMP-binding; cl15778 655816005282 AMP-binding enzyme; Region: AMP-binding; cl15778 655816005283 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816005284 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 655816005285 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655816005286 active site 655816005287 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 655816005288 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 655816005289 putative NADP binding site [chemical binding]; other site 655816005290 active site 655816005291 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816005292 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 655816005293 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655816005294 active site 655816005295 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 655816005296 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 655816005297 putative NADP binding site [chemical binding]; other site 655816005298 active site 655816005299 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816005300 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 655816005301 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655816005302 active site 655816005303 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 655816005304 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 655816005305 putative NADP binding site [chemical binding]; other site 655816005306 active site 655816005307 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 655816005308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816005309 S-adenosylmethionine binding site [chemical binding]; other site 655816005310 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816005311 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655816005312 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 655816005313 active site 655816005314 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816005315 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655816005316 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 655816005317 active site 655816005318 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816005319 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 655816005320 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 655816005321 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 655816005322 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 655816005323 active site 655816005324 catalytic triad [active] 655816005325 WYL domain; Region: WYL; cl14852 655816005326 Protein of unknown function (DUF867); Region: DUF867; cl01713 655816005327 OsmC-like protein; Region: OsmC; cl00767 655816005328 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 655816005329 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 655816005330 YmaF family; Region: YmaF; pfam12788 655816005331 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816005332 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 655816005333 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 655816005334 Sm1 motif; other site 655816005335 intra - hexamer interaction site; other site 655816005336 inter - hexamer interaction site [polypeptide binding]; other site 655816005337 nucleotide binding pocket [chemical binding]; other site 655816005338 Sm2 motif; other site 655816005339 YmzC-like protein; Region: YmzC; pfam14157 655816005340 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 655816005341 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 655816005342 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 655816005343 Class I ribonucleotide reductase; Region: RNR_I; cd01679 655816005344 active site 655816005345 dimer interface [polypeptide binding]; other site 655816005346 catalytic residues [active] 655816005347 effector binding site; other site 655816005348 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 655816005349 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 655816005350 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 655816005351 dimer interface [polypeptide binding]; other site 655816005352 putative radical transfer pathway; other site 655816005353 diiron center [ion binding]; other site 655816005354 tyrosyl radical; other site 655816005355 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 655816005356 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 655816005357 active site 655816005358 metal binding site [ion binding]; metal-binding site 655816005359 Sporulation related domain; Region: SPOR; cl10051 655816005360 stage V sporulation protein K; Region: spore_V_K; TIGR02881 655816005361 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816005362 Walker A motif; other site 655816005363 ATP binding site [chemical binding]; other site 655816005364 Walker B motif; other site 655816005365 arginine finger; other site 655816005366 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 655816005367 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 655816005368 HflX GTPase family; Region: HflX; cd01878 655816005369 G1 box; other site 655816005370 GTP/Mg2+ binding site [chemical binding]; other site 655816005371 Switch I region; other site 655816005372 G2 box; other site 655816005373 G3 box; other site 655816005374 Switch II region; other site 655816005375 G4 box; other site 655816005376 G5 box; other site 655816005377 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 655816005378 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 655816005379 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 655816005380 catalytic residue [active] 655816005381 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 655816005382 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 655816005383 DNA binding residues [nucleotide binding] 655816005384 putative dimer interface [polypeptide binding]; other site 655816005385 glutamine synthetase, type I; Region: GlnA; TIGR00653 655816005386 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 655816005387 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 655816005388 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 655816005389 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 655816005390 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 655816005391 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 655816005392 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 655816005393 inhibitor binding site; inhibition site 655816005394 active site 655816005395 Helix-turn-helix domains; Region: HTH; cl00088 655816005396 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 655816005397 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 655816005398 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 655816005399 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 655816005400 N- and C-terminal domain interface [polypeptide binding]; other site 655816005401 D-xylulose kinase; Region: XylB; TIGR01312 655816005402 active site 655816005403 catalytic site [active] 655816005404 metal binding site [ion binding]; metal-binding site 655816005405 xylulose binding site [chemical binding]; other site 655816005406 putative ATP binding site [chemical binding]; other site 655816005407 homodimer interface [polypeptide binding]; other site 655816005408 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 655816005409 Staphylococcal nuclease homologues; Region: SNc; smart00318 655816005410 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 655816005411 Catalytic site; other site 655816005412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816005413 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 655816005414 putative substrate translocation pore; other site 655816005415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816005416 alanine racemase; Region: alr; TIGR00492 655816005417 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 655816005418 active site 655816005419 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 655816005420 dimer interface [polypeptide binding]; other site 655816005421 substrate binding site [chemical binding]; other site 655816005422 catalytic residues [active] 655816005423 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 655816005424 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 655816005425 trimer interface [polypeptide binding]; other site 655816005426 active site 655816005427 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 655816005428 dimerization interface [polypeptide binding]; other site 655816005429 active site 655816005430 YoqO-like protein; Region: YoqO; pfam14037 655816005431 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 655816005432 putative hydrophobic ligand binding site [chemical binding]; other site 655816005433 Chromate transporter; Region: Chromate_transp; pfam02417 655816005434 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 655816005435 Chromate transporter; Region: Chromate_transp; pfam02417 655816005436 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 655816005437 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 655816005438 YndJ-like protein; Region: YndJ; pfam14158 655816005439 Protein of unknown function (DUF1180); Region: DUF1180; pfam06679 655816005440 Protein of unknown function (DUF867); Region: DUF867; cl01713 655816005441 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 655816005442 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 655816005443 FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363 655816005444 putative active site [active] 655816005445 putative Mg binding site [ion binding]; other site 655816005446 LexA repressor; Validated; Region: PRK00215 655816005447 Helix-turn-helix domains; Region: HTH; cl00088 655816005448 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 655816005449 Catalytic site [active] 655816005450 cell division suppressor protein YneA; Provisional; Region: PRK14125 655816005451 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 655816005452 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 655816005453 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 655816005454 catalytic residues [active] 655816005455 catalytic nucleophile [active] 655816005456 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 655816005457 transketolase, bacterial and yeast; Region: tktlase_bact; TIGR00232 655816005458 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 655816005459 TPP-binding site [chemical binding]; other site 655816005460 dimer interface [polypeptide binding]; other site 655816005461 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 655816005462 PYR/PP interface [polypeptide binding]; other site 655816005463 dimer interface [polypeptide binding]; other site 655816005464 TPP binding site [chemical binding]; other site 655816005465 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 655816005466 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 655816005467 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 655816005468 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 655816005469 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 655816005470 Response regulator receiver domain; Region: Response_reg; pfam00072 655816005471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816005472 active site 655816005473 phosphorylation site [posttranslational modification] 655816005474 intermolecular recognition site; other site 655816005475 dimerization interface [polypeptide binding]; other site 655816005476 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 655816005477 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 655816005478 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 655816005479 putative dimer interface [polypeptide binding]; other site 655816005480 Small acid-soluble spore protein P family; Region: SspP; cl12105 655816005481 Small acid-soluble spore protein O family; Region: SspO; cl07943 655816005482 aconitate hydratase; Validated; Region: PRK09277 655816005483 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 655816005484 substrate binding site [chemical binding]; other site 655816005485 ligand binding site [chemical binding]; other site 655816005486 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 655816005487 substrate binding site [chemical binding]; other site 655816005488 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 655816005489 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 655816005490 catalytic residues [active] 655816005491 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 655816005492 Small acid-soluble spore protein N family; Region: SspN; cl11659 655816005493 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830; cl07951 655816005494 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 655816005495 active site 655816005496 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 655816005497 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 655816005498 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816005499 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 655816005500 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816005501 ATP binding site [chemical binding]; other site 655816005502 Mg2+ binding site [ion binding]; other site 655816005503 G-X-G motif; other site 655816005504 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 655816005505 anchoring element; other site 655816005506 dimer interface [polypeptide binding]; other site 655816005507 ATP binding site [chemical binding]; other site 655816005508 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 655816005509 active site 655816005510 putative metal-binding site [ion binding]; other site 655816005511 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 655816005512 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 655816005513 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 655816005514 CAP-like domain; other site 655816005515 active site 655816005516 primary dimer interface [polypeptide binding]; other site 655816005517 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 655816005518 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 655816005519 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 655816005520 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 655816005521 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 655816005522 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 655816005523 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 655816005524 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 655816005525 Cellulose binding domain; Region: CBM_3; cl03026 655816005526 GtrA-like protein; Region: GtrA; cl00971 655816005527 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 655816005528 active site 655816005529 tetramer interface; other site 655816005530 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 655816005531 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 655816005532 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 655816005533 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 655816005534 classical (c) SDRs; Region: SDR_c; cd05233 655816005535 NAD(P) binding site [chemical binding]; other site 655816005536 active site 655816005537 YolD-like protein; Region: YolD; pfam08863 655816005538 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 655816005539 DHH family; Region: DHH; pfam01368 655816005540 DHHA1 domain; Region: DHHA1; pfam02272 655816005541 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 655816005542 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 655816005543 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 655816005544 enoyl-CoA hydratase; Provisional; Region: PRK07657 655816005545 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 655816005546 substrate binding site [chemical binding]; other site 655816005547 oxyanion hole (OAH) forming residues; other site 655816005548 trimer interface [polypeptide binding]; other site 655816005549 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 655816005550 active site 655816005551 catalytic residues [active] 655816005552 metal binding site [ion binding]; metal-binding site 655816005553 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 655816005554 carboxyltransferase (CT) interaction site; other site 655816005555 biotinylation site [posttranslational modification]; other site 655816005556 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 655816005557 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 655816005558 ATP-grasp domain; Region: ATP-grasp_4; cl03087 655816005559 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 655816005560 AMP-binding domain protein; Validated; Region: PRK08315 655816005561 AMP-binding enzyme; Region: AMP-binding; cl15778 655816005562 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 655816005563 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 655816005564 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 655816005565 active site 655816005566 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 655816005567 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 655816005568 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 655816005569 peptide synthase; Provisional; Region: PRK12467 655816005570 AMP-binding enzyme; Region: AMP-binding; cl15778 655816005571 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816005572 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 655816005573 AMP-binding enzyme; Region: AMP-binding; cl15778 655816005574 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816005575 peptide synthase; Provisional; Region: PRK12467 655816005576 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 655816005577 AMP-binding enzyme; Region: AMP-binding; cl15778 655816005578 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816005579 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 655816005580 peptide synthase; Provisional; Region: PRK12316 655816005581 AMP-binding enzyme; Region: AMP-binding; cl15778 655816005582 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816005583 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 655816005584 AMP-binding enzyme; Region: AMP-binding; cl15778 655816005585 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816005586 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 655816005587 AMP-binding enzyme; Region: AMP-binding; cl15778 655816005588 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816005589 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 655816005590 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 655816005591 AMP-binding enzyme; Region: AMP-binding; cl15778 655816005592 L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443 655816005593 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816005594 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655816005595 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 655816005596 active site 655816005597 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 655816005598 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816005599 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 655816005600 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 655816005601 inhibitor-cofactor binding pocket; inhibition site 655816005602 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816005603 catalytic residue [active] 655816005604 Condensation domain; Region: Condensation; pfam00668 655816005605 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 655816005606 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816005607 peptide synthase; Provisional; Region: PRK12467 655816005608 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 655816005609 AMP-binding enzyme; Region: AMP-binding; cl15778 655816005610 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816005611 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 655816005612 Acyl transferase domain; Region: Acyl_transf_1; cl08282 655816005613 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 655816005614 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 655816005615 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 655816005616 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 655816005617 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 655816005618 active site 655816005619 catalytic residues [active] 655816005620 MatE; Region: MatE; cl10513 655816005621 putative efflux protein, MATE family; Region: matE; TIGR00797 655816005622 MatE; Region: MatE; cl10513 655816005623 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 655816005624 amidase catalytic site [active] 655816005625 Zn binding residues [ion binding]; other site 655816005626 substrate binding site [chemical binding]; other site 655816005627 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 655816005628 putative peptidoglycan binding site; other site 655816005629 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 655816005630 Phage lysis protein, holin; Region: Phage_holin; cl04675 655816005631 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 655816005632 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 655816005633 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 655816005634 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 655816005635 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 655816005636 hypothetical protein; Region: PHA01818 655816005637 Phage tail protein; Region: Sipho_tail; pfam05709 655816005638 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 655816005639 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 655816005640 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 655816005641 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 655816005642 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 655816005643 oligomerization interface [polypeptide binding]; other site 655816005644 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 655816005645 Repeats in fly CG4713, worm Y37H9A.3 and human FLJ20241; Region: DM14; smart00685 655816005646 Phage capsid family; Region: Phage_capsid; pfam05065 655816005647 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 655816005648 Phage portal protein; Region: Phage_portal; pfam04860 655816005649 Phage-related protein [Function unknown]; Region: COG4695; cl01923 655816005650 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 655816005651 Phage Terminase; Region: Terminase_1; pfam03354 655816005652 Phage terminase, small subunit; Region: Terminase_4; cl01525 655816005653 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 655816005654 active site 655816005655 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 655816005656 Int/Topo IB signature motif; other site 655816005657 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 655816005658 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 655816005659 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 655816005660 cofactor binding site; other site 655816005661 DNA binding site [nucleotide binding] 655816005662 substrate interaction site [chemical binding]; other site 655816005663 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 655816005664 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816005665 Walker A motif; other site 655816005666 ATP binding site [chemical binding]; other site 655816005667 Walker B motif; other site 655816005668 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; cl09889 655816005669 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; cl09752 655816005670 Domain of unknown function (DUF771); Region: DUF771; cl09962 655816005671 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655816005672 non-specific DNA binding site [nucleotide binding]; other site 655816005673 salt bridge; other site 655816005674 sequence-specific DNA binding site [nucleotide binding]; other site 655816005675 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655816005676 sequence-specific DNA binding site [nucleotide binding]; other site 655816005677 salt bridge; other site 655816005678 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 655816005679 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 655816005680 Int/Topo IB signature motif; other site 655816005681 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 655816005682 Int/Topo IB signature motif; other site 655816005683 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 655816005684 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 655816005685 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 655816005686 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 655816005687 glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317 655816005688 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816005689 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 655816005690 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 655816005691 active site 655816005692 dimer interface [polypeptide binding]; other site 655816005693 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 655816005694 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 655816005695 active site 655816005696 FMN binding site [chemical binding]; other site 655816005697 substrate binding site [chemical binding]; other site 655816005698 3Fe-4S cluster binding site [ion binding]; other site 655816005699 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 655816005700 domain interface; other site 655816005701 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655816005702 Helix-turn-helix domains; Region: HTH; cl00088 655816005703 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 655816005704 putative dimerization interface [polypeptide binding]; other site 655816005705 gamma-glutamyl kinase; Provisional; Region: PRK13402 655816005706 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 655816005707 nucleotide binding site [chemical binding]; other site 655816005708 homotetrameric interface [polypeptide binding]; other site 655816005709 putative phosphate binding site [ion binding]; other site 655816005710 putative allosteric binding site; other site 655816005711 PUA domain; Region: PUA; cl00607 655816005712 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816005713 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 655816005714 Replication terminator protein; Region: RTP; pfam02334 655816005715 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 655816005716 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 655816005717 classical (c) SDRs; Region: SDR_c; cd05233 655816005718 NAD(P) binding site [chemical binding]; other site 655816005719 active site 655816005720 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 655816005721 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 655816005722 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 655816005723 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 655816005724 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816005725 Q-loop/lid; other site 655816005726 ABC transporter signature motif; other site 655816005727 Walker B; other site 655816005728 D-loop; other site 655816005729 H-loop/switch region; other site 655816005730 polyol permease family; Region: 2A0118; TIGR00897 655816005731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816005732 putative substrate translocation pore; other site 655816005733 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 655816005734 Autoinducer-2 kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K_like; cd07798 655816005735 putative N- and C-terminal domain interface [polypeptide binding]; other site 655816005736 putative active site [active] 655816005737 putative MgATP binding site [chemical binding]; other site 655816005738 catalytic site [active] 655816005739 metal binding site [ion binding]; metal-binding site 655816005740 carbohydrate binding site [chemical binding]; other site 655816005741 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 655816005742 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816005743 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 655816005744 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 655816005745 putative [4Fe-4S] binding site [ion binding]; other site 655816005746 putative molybdopterin cofactor binding site [chemical binding]; other site 655816005747 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 655816005748 putative molybdopterin cofactor binding site; other site 655816005749 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 655816005750 CHASE3 domain; Region: CHASE3; cl05000 655816005751 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 655816005752 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 655816005753 dimerization interface [polypeptide binding]; other site 655816005754 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 655816005755 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 655816005756 dimer interface [polypeptide binding]; other site 655816005757 putative CheW interface [polypeptide binding]; other site 655816005758 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 655816005759 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 655816005760 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 655816005761 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 655816005762 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 655816005763 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 655816005764 Pectate lyase; Region: Pec_lyase_C; cl01593 655816005765 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816005766 NAD(P) binding site [chemical binding]; other site 655816005767 active site 655816005768 Necrosis inducing protein (NPP1); Region: NPP1; pfam05630 655816005769 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 655816005770 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 655816005771 VanW like protein; Region: VanW; pfam04294 655816005772 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 655816005773 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 655816005774 Protein of unknown function (DUF817); Region: DUF817; cl01520 655816005775 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655816005776 Helix-turn-helix domains; Region: HTH; cl00088 655816005777 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 655816005778 dimerization interface [polypeptide binding]; other site 655816005779 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 655816005780 EamA-like transporter family; Region: EamA; cl01037 655816005781 EamA-like transporter family; Region: EamA; cl01037 655816005782 CAAX protease self-immunity; Region: Abi; cl00558 655816005783 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 655816005784 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 655816005785 conserved cys residue [active] 655816005786 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 655816005787 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 655816005788 Chitin binding domain; Region: Chitin_bind_3; cl03871 655816005789 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 655816005790 DinB superfamily; Region: DinB_2; pfam12867 655816005791 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 655816005792 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 655816005793 DNA polymerase IV; Reviewed; Region: PRK03103 655816005794 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 655816005795 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 655816005796 Probable Catalytic site; other site 655816005797 metal-binding site 655816005798 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816005799 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 655816005800 putative metal binding site; other site 655816005801 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816005802 binding surface 655816005803 TPR motif; other site 655816005804 TPR repeat; Region: TPR_11; pfam13414 655816005805 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816005806 binding surface 655816005807 TPR motif; other site 655816005808 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816005809 S-adenosylmethionine binding site [chemical binding]; other site 655816005810 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 655816005811 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; cl02047 655816005812 Domain of unknown function (DUF303); Region: DUF303; pfam03629 655816005813 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 655816005814 DNA binding site [nucleotide binding] 655816005815 active site 655816005816 Int/Topo IB signature motif; other site 655816005817 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 655816005818 active site 655816005819 active site 655816005820 catalytic residues [active] 655816005821 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 655816005822 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 655816005823 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 655816005824 dimer interface [polypeptide binding]; other site 655816005825 putative tRNA-binding site [nucleotide binding]; other site 655816005826 Cupin domain; Region: Cupin_2; cl09118 655816005827 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655816005828 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 655816005829 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655816005830 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816005831 Coenzyme A binding pocket [chemical binding]; other site 655816005832 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655816005833 WHG domain; Region: WHG; pfam13305 655816005834 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 655816005835 Predicted transcriptional regulator [Transcription]; Region: COG2378 655816005836 Helix-turn-helix domains; Region: HTH; cl00088 655816005837 WYL domain; Region: WYL; cl14852 655816005838 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 655816005839 dimerization interface [polypeptide binding]; other site 655816005840 putative DNA binding site [nucleotide binding]; other site 655816005841 putative Zn2+ binding site [ion binding]; other site 655816005842 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 655816005843 Protein of unknown function (DUF420); Region: DUF420; cl00989 655816005844 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 655816005845 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 655816005846 putative dimer interface [polypeptide binding]; other site 655816005847 catalytic triad [active] 655816005848 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 655816005849 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 655816005850 putative di-iron ligands [ion binding]; other site 655816005851 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 655816005852 Histidine kinase; Region: HisKA_3; pfam07730 655816005853 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 655816005854 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 655816005855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816005856 active site 655816005857 phosphorylation site [posttranslational modification] 655816005858 intermolecular recognition site; other site 655816005859 dimerization interface [polypeptide binding]; other site 655816005860 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655816005861 DNA binding residues [nucleotide binding] 655816005862 dimerization interface [polypeptide binding]; other site 655816005863 Sodium:solute symporter family; Region: SSF; cl00456 655816005864 putative transporter; Provisional; Region: PRK10484 655816005865 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 655816005866 putative peptidoglycan binding site; other site 655816005867 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 655816005868 putative peptidoglycan binding site; other site 655816005869 DNA polymerase III subunits gamma and tau; Validated; Region: PRK08691 655816005870 3D domain; Region: 3D; cl01439 655816005871 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 655816005872 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 655816005873 ATP binding site [chemical binding]; other site 655816005874 putative Mg++ binding site [ion binding]; other site 655816005875 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655816005876 nucleotide binding region [chemical binding]; other site 655816005877 ATP-binding site [chemical binding]; other site 655816005878 RQC domain; Region: RQC; cl09632 655816005879 HRDC domain; Region: HRDC; cl02578 655816005880 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 655816005881 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 655816005882 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 655816005883 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 655816005884 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 655816005885 NAD(P) binding site [chemical binding]; other site 655816005886 catalytic residues [active] 655816005887 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 655816005888 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 655816005889 Squalene cyclase [Lipid metabolism]; Region: SqhC; COG1657 655816005890 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 655816005891 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 655816005892 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 655816005893 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 655816005894 bile acid transporter; Region: bass; TIGR00841 655816005895 Membrane transport protein; Region: Mem_trans; cl09117 655816005896 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 655816005897 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 655816005898 E3 interaction surface; other site 655816005899 lipoyl attachment site [posttranslational modification]; other site 655816005900 e3 binding domain; Region: E3_binding; pfam02817 655816005901 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 655816005902 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 655816005903 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 655816005904 TPP-binding site [chemical binding]; other site 655816005905 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 655816005906 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 655816005907 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 655816005908 metal ion-dependent adhesion site (MIDAS); other site 655816005909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816005910 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 655816005911 Walker A motif; other site 655816005912 ATP binding site [chemical binding]; other site 655816005913 Walker B motif; other site 655816005914 arginine finger; other site 655816005915 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 655816005916 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 655816005917 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 655816005918 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 655816005919 E-class dimer interface [polypeptide binding]; other site 655816005920 P-class dimer interface [polypeptide binding]; other site 655816005921 active site 655816005922 Cu2+ binding site [ion binding]; other site 655816005923 Zn2+ binding site [ion binding]; other site 655816005924 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 655816005925 putative peptidoglycan binding site; other site 655816005926 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 655816005927 putative peptidoglycan binding site; other site 655816005928 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 655816005929 putative peptidoglycan binding site; other site 655816005930 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 655816005931 putative peptidoglycan binding site; other site 655816005932 NlpC/P60 family; Region: NLPC_P60; cl11438 655816005933 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 655816005934 glycosyltransferase, MGT family; Region: MGT; TIGR01426 655816005935 active site 655816005936 TDP-binding site; other site 655816005937 acceptor substrate-binding pocket; other site 655816005938 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 655816005939 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 655816005940 multidrug efflux protein; Reviewed; Region: PRK01766 655816005941 MatE; Region: MatE; cl10513 655816005942 MatE; Region: MatE; cl10513 655816005943 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 655816005944 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 655816005945 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 655816005946 rarD protein; Region: rarD; TIGR00688 655816005947 EamA-like transporter family; Region: EamA; cl01037 655816005948 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 655816005949 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 655816005950 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 655816005951 dimerization interface [polypeptide binding]; other site 655816005952 putative DNA binding site [nucleotide binding]; other site 655816005953 putative Zn2+ binding site [ion binding]; other site 655816005954 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 655816005955 dimer interface [polypeptide binding]; other site 655816005956 FMN binding site [chemical binding]; other site 655816005957 Predicted esterase [General function prediction only]; Region: COG0400 655816005958 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 655816005959 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 655816005960 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 655816005961 Zn binding site [ion binding]; other site 655816005962 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 655816005963 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 655816005964 Sodium:solute symporter family; Region: SSF; cl00456 655816005965 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 655816005966 C-terminal peptidase (prc); Region: prc; TIGR00225 655816005967 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 655816005968 protein binding site [polypeptide binding]; other site 655816005969 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 655816005970 Catalytic dyad [active] 655816005971 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 655816005972 Methyltransferase domain; Region: Methyltransf_31; pfam13847 655816005973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816005974 S-adenosylmethionine binding site [chemical binding]; other site 655816005975 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816005976 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 655816005977 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 655816005978 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 655816005979 YodL-like; Region: YodL; pfam14191 655816005980 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 655816005981 active site 655816005982 YozD-like protein; Region: YozD; pfam14162 655816005983 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 655816005984 YokU-like protein; Region: YokU; cl15819 655816005985 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 655816005986 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655816005987 FeS/SAM binding site; other site 655816005988 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 655816005989 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 655816005990 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816005991 Coenzyme A binding pocket [chemical binding]; other site 655816005992 acetylornithine deacetylase; Validated; Region: PRK06915 655816005993 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 655816005994 metal binding site [ion binding]; metal-binding site 655816005995 dimer interface [polypeptide binding]; other site 655816005996 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 655816005997 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 655816005998 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 655816005999 hypothetical protein; Provisional; Region: PRK06917 655816006000 inhibitor-cofactor binding pocket; inhibition site 655816006001 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816006002 catalytic residue [active] 655816006003 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816006004 Coenzyme A binding pocket [chemical binding]; other site 655816006005 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 655816006006 active site 655816006007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 655816006008 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 655816006009 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 655816006010 3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase) [Lipid metabolism]; Region: Phy; COG4247 655816006011 Phytase; Region: Phytase; pfam02333 655816006012 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 655816006013 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 655816006014 NAD(P) binding site [chemical binding]; other site 655816006015 homodimer interface [polypeptide binding]; other site 655816006016 substrate binding site [chemical binding]; other site 655816006017 active site 655816006018 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 655816006019 SelR domain; Region: SelR; pfam01641 655816006020 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 655816006021 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816006022 Helix-turn-helix domains; Region: HTH; cl00088 655816006023 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 655816006024 MatE; Region: MatE; cl10513 655816006025 MatE; Region: MatE; cl10513 655816006026 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 655816006027 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 655816006028 active site 655816006029 catalytic triad [active] 655816006030 oxyanion hole [active] 655816006031 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 655816006032 Cu(I) binding site [ion binding]; other site 655816006033 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 655816006034 threonine dehydratase; Validated; Region: PRK08639 655816006035 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 655816006036 tetramer interface [polypeptide binding]; other site 655816006037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816006038 catalytic residue [active] 655816006039 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 655816006040 putative Ile/Val binding site [chemical binding]; other site 655816006041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816006042 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 655816006043 Walker A motif; other site 655816006044 ATP binding site [chemical binding]; other site 655816006045 Walker B motif; other site 655816006046 arginine finger; other site 655816006047 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 655816006048 Haemolysin-III related; Region: HlyIII; cl03831 655816006049 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 655816006050 putative acyl-acceptor binding pocket; other site 655816006051 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 655816006052 folate binding site [chemical binding]; other site 655816006053 NADP+ binding site [chemical binding]; other site 655816006054 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 655816006055 dimerization interface [polypeptide binding]; other site 655816006056 active site 655816006057 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 655816006058 tetramer interfaces [polypeptide binding]; other site 655816006059 binuclear metal-binding site [ion binding]; other site 655816006060 YpjP-like protein; Region: YpjP; pfam14005 655816006061 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816006062 Disulphide isomerase; Region: Disulph_isomer; pfam06491 655816006063 Dehydratase family; Region: ILVD_EDD; cl00340 655816006064 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 655816006065 Virulence factor; Region: Virulence_fact; pfam13769 655816006066 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 655816006067 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 655816006068 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 655816006069 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 655816006070 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 655816006071 Zn2+ binding site [ion binding]; other site 655816006072 Mg2+ binding site [ion binding]; other site 655816006073 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 655816006074 catalytic residues [active] 655816006075 dimer interface [polypeptide binding]; other site 655816006076 homoserine O-succinyltransferase; Provisional; Region: PRK05368 655816006077 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 655816006078 proposed active site lysine [active] 655816006079 conserved cys residue [active] 655816006080 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 655816006081 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 655816006082 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 655816006083 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 655816006084 DNA-binding site [nucleotide binding]; DNA binding site 655816006085 RNA-binding motif; other site 655816006086 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 655816006087 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 655816006088 hypothetical protein; Validated; Region: PRK07708 655816006089 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 655816006090 RNA/DNA hybrid binding site [nucleotide binding]; other site 655816006091 active site 655816006092 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 655816006093 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 655816006094 RNA/DNA hybrid binding site [nucleotide binding]; other site 655816006095 active site 655816006096 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 655816006097 5'-3' exonuclease; Region: 53EXOc; smart00475 655816006098 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 655816006099 active site 655816006100 metal binding site 1 [ion binding]; metal-binding site 655816006101 putative 5' ssDNA interaction site; other site 655816006102 metal binding site 3; metal-binding site 655816006103 metal binding site 2 [ion binding]; metal-binding site 655816006104 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 655816006105 putative DNA binding site [nucleotide binding]; other site 655816006106 putative metal binding site [ion binding]; other site 655816006107 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 655816006108 GTP-binding protein Der; Reviewed; Region: PRK00093 655816006109 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 655816006110 Dynamin family; Region: Dynamin_N; pfam00350 655816006111 G1 box; other site 655816006112 GTP/Mg2+ binding site [chemical binding]; other site 655816006113 G2 box; other site 655816006114 Switch I region; other site 655816006115 G3 box; other site 655816006116 Switch II region; other site 655816006117 G4 box; other site 655816006118 G5 box; other site 655816006119 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816006120 G1 box; other site 655816006121 GTP/Mg2+ binding site [chemical binding]; other site 655816006122 Dynamin family; Region: Dynamin_N; pfam00350 655816006123 G2 box; other site 655816006124 Switch I region; other site 655816006125 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 655816006126 G3 box; other site 655816006127 Switch II region; other site 655816006128 GTP/Mg2+ binding site [chemical binding]; other site 655816006129 G4 box; other site 655816006130 G5 box; other site 655816006131 Phospholipid methyltransferase; Region: PEMT; cl00763 655816006132 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 655816006133 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 655816006134 malonyl-CoA binding site [chemical binding]; other site 655816006135 dimer interface [polypeptide binding]; other site 655816006136 active site 655816006137 product binding site; other site 655816006138 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 655816006139 xanthine permease; Region: pbuX; TIGR03173 655816006140 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 655816006141 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 655816006142 active site 655816006143 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 655816006144 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 655816006145 active site 655816006146 Zn binding site [ion binding]; other site 655816006147 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 655816006148 KDPG and KHG aldolase; Region: Aldolase; pfam01081 655816006149 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 655816006150 active site 655816006151 intersubunit interface [polypeptide binding]; other site 655816006152 catalytic residue [active] 655816006153 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 655816006154 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 655816006155 substrate binding site [chemical binding]; other site 655816006156 ATP binding site [chemical binding]; other site 655816006157 Transcriptional regulators [Transcription]; Region: PurR; COG1609 655816006158 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655816006159 DNA binding site [nucleotide binding] 655816006160 domain linker motif; other site 655816006161 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 655816006162 putative dimerization interface [polypeptide binding]; other site 655816006163 putative ligand binding site [chemical binding]; other site 655816006164 KduI/IolB family; Region: KduI; cl01508 655816006165 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 655816006166 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 655816006167 NADP binding site [chemical binding]; other site 655816006168 homodimer interface [polypeptide binding]; other site 655816006169 active site 655816006170 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 655816006171 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816006172 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816006173 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 655816006174 THUMP domain; Region: THUMP; cl12076 655816006175 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816006176 cell division protein GpsB; Provisional; Region: PRK14127 655816006177 DivIVA domain; Region: DivI1A_domain; TIGR03544 655816006178 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 655816006179 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 655816006180 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 655816006181 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 655816006182 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 655816006183 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 655816006184 ATP binding site [chemical binding]; other site 655816006185 putative Mg++ binding site [ion binding]; other site 655816006186 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655816006187 nucleotide binding region [chemical binding]; other site 655816006188 ATP-binding site [chemical binding]; other site 655816006189 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 655816006190 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 655816006191 HPr interaction site; other site 655816006192 glycerol kinase (GK) interaction site [polypeptide binding]; other site 655816006193 active site 655816006194 phosphorylation site [posttranslational modification] 655816006195 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 655816006196 YppG-like protein; Region: YppG; pfam14179 655816006197 YppF-like protein; Region: YppF; pfam14178 655816006198 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 655816006199 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 655816006200 Recombination protein U; Region: RecU; cl01314 655816006201 Transglycosylase; Region: Transgly; cl07896 655816006202 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 655816006203 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 655816006204 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 655816006205 Interdomain contacts; other site 655816006206 Cytokine receptor motif; other site 655816006207 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 655816006208 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 655816006209 minor groove reading motif; other site 655816006210 helix-hairpin-helix signature motif; other site 655816006211 substrate binding pocket [chemical binding]; other site 655816006212 active site 655816006213 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 655816006214 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 655816006215 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 655816006216 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 655816006217 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 655816006218 putative dimer interface [polypeptide binding]; other site 655816006219 putative anticodon binding site; other site 655816006220 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 655816006221 homodimer interface [polypeptide binding]; other site 655816006222 motif 1; other site 655816006223 motif 2; other site 655816006224 active site 655816006225 motif 3; other site 655816006226 aspartate aminotransferase; Provisional; Region: PRK05764 655816006227 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655816006228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816006229 homodimer interface [polypeptide binding]; other site 655816006230 catalytic residue [active] 655816006231 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 655816006232 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 655816006233 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 655816006234 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 655816006235 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 655816006236 active site 655816006237 substrate binding site [chemical binding]; other site 655816006238 catalytic site [active] 655816006239 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816006240 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 655816006241 tetramerization interface [polypeptide binding]; other site 655816006242 active site 655816006243 pantoate--beta-alanine ligase; Region: panC; TIGR00018 655816006244 Pantoate-beta-alanine ligase; Region: PanC; cd00560 655816006245 active site 655816006246 ATP-binding site [chemical binding]; other site 655816006247 pantoate-binding site; other site 655816006248 HXXH motif; other site 655816006249 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 655816006250 oligomerization interface [polypeptide binding]; other site 655816006251 active site 655816006252 metal binding site [ion binding]; metal-binding site 655816006253 Helix-turn-helix domains; Region: HTH; cl00088 655816006254 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 655816006255 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 655816006256 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 655816006257 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 655816006258 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 655816006259 active site 655816006260 NTP binding site [chemical binding]; other site 655816006261 metal binding triad [ion binding]; metal-binding site 655816006262 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 655816006263 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 655816006264 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 655816006265 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 655816006266 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 655816006267 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 655816006268 active site 655816006269 dimer interfaces [polypeptide binding]; other site 655816006270 catalytic residues [active] 655816006271 dihydrodipicolinate reductase; Region: dapB; TIGR00036 655816006272 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816006273 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 655816006274 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 655816006275 Uncharacterized conserved protein [Function unknown]; Region: COG1284 655816006276 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 655816006277 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 655816006278 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 655816006279 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 655816006280 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 655816006281 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 655816006282 Cytochrome c; Region: Cytochrom_C; cl11414 655816006283 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 655816006284 interchain domain interface [polypeptide binding]; other site 655816006285 intrachain domain interface; other site 655816006286 heme bH binding site [chemical binding]; other site 655816006287 Qi binding site; other site 655816006288 heme bL binding site [chemical binding]; other site 655816006289 Qo binding site; other site 655816006290 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 655816006291 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 655816006292 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 655816006293 iron-sulfur cluster [ion binding]; other site 655816006294 [2Fe-2S] cluster binding site [ion binding]; other site 655816006295 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 655816006296 hypothetical protein; Provisional; Region: PRK03636 655816006297 UPF0302 domain; Region: UPF0302; pfam08864 655816006298 IDEAL domain; Region: IDEAL; cl07452 655816006299 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 655816006300 TPR motif; other site 655816006301 binding surface 655816006302 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816006303 binding surface 655816006304 TPR motif; other site 655816006305 Tetratricopeptide repeat; Region: TPR_16; pfam13432 655816006306 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816006307 TPR motif; other site 655816006308 binding surface 655816006309 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 655816006310 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816006311 binding surface 655816006312 TPR motif; other site 655816006313 Tetratricopeptide repeat; Region: TPR_16; pfam13432 655816006314 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 655816006315 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 655816006316 hinge; other site 655816006317 active site 655816006318 prephenate dehydrogenase; Validated; Region: PRK06545 655816006319 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816006320 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 655816006321 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 655816006322 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655816006323 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816006324 homodimer interface [polypeptide binding]; other site 655816006325 catalytic residue [active] 655816006326 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 655816006327 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 655816006328 substrate binding site [chemical binding]; other site 655816006329 active site 655816006330 catalytic residues [active] 655816006331 heterodimer interface [polypeptide binding]; other site 655816006332 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 655816006333 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 655816006334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816006335 catalytic residue [active] 655816006336 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 655816006337 active site 655816006338 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 655816006339 active site 655816006340 ribulose/triose binding site [chemical binding]; other site 655816006341 phosphate binding site [ion binding]; other site 655816006342 substrate (anthranilate) binding pocket [chemical binding]; other site 655816006343 product (indole) binding pocket [chemical binding]; other site 655816006344 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 655816006345 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 655816006346 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 655816006347 anthranilate synthase component I; Provisional; Region: PRK13569 655816006348 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 655816006349 chorismate binding enzyme; Region: Chorismate_bind; cl10555 655816006350 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 655816006351 homotrimer interaction site [polypeptide binding]; other site 655816006352 active site 655816006353 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 655816006354 active site 655816006355 dimer interface [polypeptide binding]; other site 655816006356 metal binding site [ion binding]; metal-binding site 655816006357 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 655816006358 Tetramer interface [polypeptide binding]; other site 655816006359 active site 655816006360 FMN-binding site [chemical binding]; other site 655816006361 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 655816006362 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 655816006363 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816006364 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 655816006365 active site 655816006366 multimer interface [polypeptide binding]; other site 655816006367 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 655816006368 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 655816006369 substrate binding pocket [chemical binding]; other site 655816006370 chain length determination region; other site 655816006371 substrate-Mg2+ binding site; other site 655816006372 catalytic residues [active] 655816006373 aspartate-rich region 1; other site 655816006374 active site lid residues [active] 655816006375 aspartate-rich region 2; other site 655816006376 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 655816006377 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816006378 S-adenosylmethionine binding site [chemical binding]; other site 655816006379 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 655816006380 Tryptophan RNA-binding attenuator protein; Region: TrpBP; cl03437 655816006381 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 655816006382 homodecamer interface [polypeptide binding]; other site 655816006383 GTP cyclohydrolase I; Provisional; Region: PLN03044 655816006384 active site 655816006385 putative catalytic site residues [active] 655816006386 zinc binding site [ion binding]; other site 655816006387 GTP-CH-I/GFRP interaction surface; other site 655816006388 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 655816006389 IHF dimer interface [polypeptide binding]; other site 655816006390 IHF - DNA interface [nucleotide binding]; other site 655816006391 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; cl09772 655816006392 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 655816006393 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 655816006394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816006395 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 655816006396 GTP-binding protein Der; Reviewed; Region: PRK00093 655816006397 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 655816006398 G1 box; other site 655816006399 GTP/Mg2+ binding site [chemical binding]; other site 655816006400 Switch I region; other site 655816006401 G2 box; other site 655816006402 Switch II region; other site 655816006403 G3 box; other site 655816006404 G4 box; other site 655816006405 G5 box; other site 655816006406 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 655816006407 G1 box; other site 655816006408 GTP/Mg2+ binding site [chemical binding]; other site 655816006409 Switch I region; other site 655816006410 G2 box; other site 655816006411 G3 box; other site 655816006412 Switch II region; other site 655816006413 G4 box; other site 655816006414 G5 box; other site 655816006415 YIEGIA protein; Region: YIEGIA; pfam14045 655816006416 YpzI-like protein; Region: YpzI; pfam14140 655816006417 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 655816006418 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 655816006419 homotetramer interface [polypeptide binding]; other site 655816006420 FMN binding site [chemical binding]; other site 655816006421 homodimer contacts [polypeptide binding]; other site 655816006422 putative active site [active] 655816006423 putative substrate binding site [chemical binding]; other site 655816006424 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 655816006425 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 655816006426 RNA binding site [nucleotide binding]; other site 655816006427 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 655816006428 RNA binding site [nucleotide binding]; other site 655816006429 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 655816006430 RNA binding site [nucleotide binding]; other site 655816006431 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 655816006432 RNA binding site [nucleotide binding]; other site 655816006433 cytidylate kinase; Provisional; Region: cmk; PRK00023 655816006434 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 655816006435 CMP-binding site; other site 655816006436 The sites determining sugar specificity; other site 655816006437 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 655816006438 Flagellar protein YcgR; Region: YcgR_2; pfam12945 655816006439 PilZ domain; Region: PilZ; cl01260 655816006440 germination protein YpeB; Region: spore_YpeB; TIGR02889 655816006441 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 655816006442 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 655816006443 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 655816006444 Protease prsW family; Region: PrsW-protease; cl15823 655816006445 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 655816006446 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816006447 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655816006448 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 655816006449 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 655816006450 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 655816006451 NAD(P) binding site [chemical binding]; other site 655816006452 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 655816006453 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 655816006454 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 655816006455 putative active site [active] 655816006456 putative metal binding site [ion binding]; other site 655816006457 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 655816006458 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 655816006459 CAAX protease self-immunity; Region: Abi; cl00558 655816006460 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 655816006461 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 655816006462 ATP binding site [chemical binding]; other site 655816006463 putative Mg++ binding site [ion binding]; other site 655816006464 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655816006465 nucleotide binding region [chemical binding]; other site 655816006466 ATP-binding site [chemical binding]; other site 655816006467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 655816006468 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 655816006469 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 655816006470 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 655816006471 D-3-phosphoglycerate dehydrogenase; Region: PGDH; TIGR01327 655816006472 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816006473 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 655816006474 putative L-serine binding site [chemical binding]; other site 655816006475 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 655816006476 3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093 655816006477 active site 655816006478 catalytic residue [active] 655816006479 dimer interface [polypeptide binding]; other site 655816006480 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 655816006481 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655816006482 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655816006483 DNA binding residues [nucleotide binding] 655816006484 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 655816006485 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 655816006486 dimerization interface [polypeptide binding]; other site 655816006487 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 655816006488 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655816006489 dimer interface [polypeptide binding]; other site 655816006490 phosphorylation site [posttranslational modification] 655816006491 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816006492 ATP binding site [chemical binding]; other site 655816006493 Mg2+ binding site [ion binding]; other site 655816006494 G-X-G motif; other site 655816006495 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 655816006496 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816006497 active site 655816006498 phosphorylation site [posttranslational modification] 655816006499 intermolecular recognition site; other site 655816006500 dimerization interface [polypeptide binding]; other site 655816006501 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655816006502 DNA binding site [nucleotide binding] 655816006503 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 655816006504 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 655816006505 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 655816006506 ResB-like family; Region: ResB; pfam05140 655816006507 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 655816006508 catalytic residues [active] 655816006509 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 655816006510 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 655816006511 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 655816006512 active site 655816006513 Nucleoside recognition; Region: Gate; cl00486 655816006514 Nucleoside recognition; Region: Gate; cl00486 655816006515 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 655816006516 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 655816006517 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 655816006518 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 655816006519 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 655816006520 ScpA/B protein; Region: ScpA_ScpB; cl00598 655816006521 Domain of unknown function (DUF309); Region: DUF309; cl00667 655816006522 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816006523 Coenzyme A binding pocket [chemical binding]; other site 655816006524 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 655816006525 homopentamer interface [polypeptide binding]; other site 655816006526 active site 655816006527 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 655816006528 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 655816006529 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 655816006530 dimerization interface [polypeptide binding]; other site 655816006531 active site 655816006532 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 655816006533 Lumazine binding domain; Region: Lum_binding; pfam00677 655816006534 Lumazine binding domain; Region: Lum_binding; pfam00677 655816006535 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 655816006536 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 655816006537 catalytic motif [active] 655816006538 Zn binding site [ion binding]; other site 655816006539 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 655816006540 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 655816006541 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 655816006542 Catalytic site [active] 655816006543 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381 655816006544 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 655816006545 active site 655816006546 Predicted secreted protein [Function unknown]; Region: COG4086 655816006547 diaminopimelate decarboxylase; Region: lysA; TIGR01048 655816006548 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 655816006549 active site 655816006550 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 655816006551 substrate binding site [chemical binding]; other site 655816006552 catalytic residues [active] 655816006553 dimer interface [polypeptide binding]; other site 655816006554 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 655816006555 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 655816006556 SpoVA protein; Region: SpoVA; cl04298 655816006557 stage V sporulation protein AD; Validated; Region: PRK08304 655816006558 stage V sporulation protein AD; Provisional; Region: PRK12404 655816006559 SpoVA protein; Region: SpoVA; cl04298 655816006560 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 655816006561 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 655816006562 sporulation sigma factor SigF; Validated; Region: PRK05572 655816006563 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655816006564 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 655816006565 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655816006566 DNA binding residues [nucleotide binding] 655816006567 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 655816006568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816006569 ATP binding site [chemical binding]; other site 655816006570 Mg2+ binding site [ion binding]; other site 655816006571 G-X-G motif; other site 655816006572 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 655816006573 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 655816006574 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 655816006575 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 655816006576 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 655816006577 Sulfatase; Region: Sulfatase; cl10460 655816006578 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 655816006579 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 655816006580 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 655816006581 Int/Topo IB signature motif; other site 655816006582 active site 655816006583 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 655816006584 ferric uptake regulator; Provisional; Region: fur; PRK09462 655816006585 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 655816006586 metal binding site 2 [ion binding]; metal-binding site 655816006587 putative DNA binding helix; other site 655816006588 metal binding site 1 [ion binding]; metal-binding site 655816006589 dimer interface [polypeptide binding]; other site 655816006590 structural Zn2+ binding site [ion binding]; other site 655816006591 Integral membrane protein DUF95; Region: DUF95; cl00572 655816006592 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 655816006593 Malic enzyme, N-terminal domain; Region: malic; pfam00390 655816006594 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816006595 NAD(P) binding pocket [chemical binding]; other site 655816006596 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 655816006597 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 655816006598 Aspartase; Region: Aspartase; cd01357 655816006599 active sites [active] 655816006600 tetramer interface [polypeptide binding]; other site 655816006601 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 655816006602 active site 655816006603 homodimer interface [polypeptide binding]; other site 655816006604 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 655816006605 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655816006606 non-specific DNA binding site [nucleotide binding]; other site 655816006607 salt bridge; other site 655816006608 sequence-specific DNA binding site [nucleotide binding]; other site 655816006609 TIGR00375 family protein; Region: TIGR00375 655816006610 Helix-turn-helix domains; Region: HTH; cl00088 655816006611 putative transposase OrfB; Reviewed; Region: PHA02517 655816006612 HTH-like domain; Region: HTH_21; pfam13276 655816006613 Integrase core domain; Region: rve; cl01316 655816006614 Integrase core domain; Region: rve_3; cl15866 655816006615 TIGR00375 family protein; Region: TIGR00375 655816006616 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 655816006617 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 655816006618 dimer interface [polypeptide binding]; other site 655816006619 ADP-ribose binding site [chemical binding]; other site 655816006620 active site 655816006621 nudix motif; other site 655816006622 metal binding site [ion binding]; metal-binding site 655816006623 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 655816006624 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 655816006625 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 655816006626 active site 655816006627 catalytic tetrad [active] 655816006628 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 655816006629 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 655816006630 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750 655816006631 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 655816006632 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 655816006633 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 655816006634 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 655816006635 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 655816006636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 655816006637 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816006638 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 655816006639 Coenzyme A binding pocket [chemical binding]; other site 655816006640 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 655816006641 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 655816006642 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 655816006643 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816006644 Coenzyme A binding pocket [chemical binding]; other site 655816006645 YolD-like protein; Region: YolD; pfam08863 655816006646 DNA polymerase IV; Reviewed; Region: PRK03103 655816006647 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 655816006648 active site 655816006649 DNA binding site [nucleotide binding] 655816006650 YqzH-like protein; Region: YqzH; pfam14164 655816006651 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 655816006652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816006653 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816006654 putative substrate translocation pore; other site 655816006655 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 655816006656 putative dimer interface [polypeptide binding]; other site 655816006657 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 655816006658 ligand binding site [chemical binding]; other site 655816006659 Zn binding site [ion binding]; other site 655816006660 pantothenate kinase; Provisional; Region: PRK05439 655816006661 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 655816006662 ATP-binding site [chemical binding]; other site 655816006663 CoA-binding site [chemical binding]; other site 655816006664 Mg2+-binding site [ion binding]; other site 655816006665 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 655816006666 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 655816006667 catalytic residue [active] 655816006668 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 655816006669 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332 655816006670 NADP binding site [chemical binding]; other site 655816006671 homodimer interface [polypeptide binding]; other site 655816006672 substrate binding site [chemical binding]; other site 655816006673 active site 655816006674 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 655816006675 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 655816006676 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816006677 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 655816006678 Arginine degradation protein (predicted deacylase) [Amino acid transport and metabolism]; Region: RocB; COG4187 655816006679 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 655816006680 putative metal binding site [ion binding]; other site 655816006681 putative dimer interface [polypeptide binding]; other site 655816006682 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 655816006683 active site 655816006684 FMN binding site [chemical binding]; other site 655816006685 substrate binding site [chemical binding]; other site 655816006686 homotetramer interface [polypeptide binding]; other site 655816006687 catalytic residue [active] 655816006688 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 655816006689 Helix-turn-helix domains; Region: HTH; cl00088 655816006690 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 655816006691 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 655816006692 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 655816006693 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 655816006694 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 655816006695 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816006696 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 655816006697 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 655816006698 DNA polymerase IV; Validated; Region: PRK01810 655816006699 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 655816006700 active site 655816006701 DNA binding site [nucleotide binding] 655816006702 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 655816006703 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 655816006704 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 655816006705 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 655816006706 peptidase T-like protein; Region: PepT-like; TIGR01883 655816006707 metal binding site [ion binding]; metal-binding site 655816006708 putative dimer interface [polypeptide binding]; other site 655816006709 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 655816006710 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 655816006711 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 655816006712 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 655816006713 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 655816006714 dimer interface [polypeptide binding]; other site 655816006715 substrate binding site [chemical binding]; other site 655816006716 metal binding site [ion binding]; metal-binding site 655816006717 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 655816006718 Predicted membrane protein [Function unknown]; Region: COG4129 655816006719 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 655816006720 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 655816006721 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 655816006722 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 655816006723 Walker A/P-loop; other site 655816006724 ATP binding site [chemical binding]; other site 655816006725 Q-loop/lid; other site 655816006726 ABC transporter signature motif; other site 655816006727 Walker B; other site 655816006728 D-loop; other site 655816006729 H-loop/switch region; other site 655816006730 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 655816006731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816006732 dimer interface [polypeptide binding]; other site 655816006733 conserved gate region; other site 655816006734 putative PBP binding loops; other site 655816006735 ABC-ATPase subunit interface; other site 655816006736 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 655816006737 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 655816006738 substrate binding pocket [chemical binding]; other site 655816006739 membrane-bound complex binding site; other site 655816006740 hinge residues; other site 655816006741 Disulphide isomerase; Region: Disulph_isomer; pfam06491 655816006742 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 655816006743 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 655816006744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816006745 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816006746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816006747 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 655816006748 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 655816006749 DNA binding residues [nucleotide binding] 655816006750 drug binding residues [chemical binding]; other site 655816006751 dimer interface [polypeptide binding]; other site 655816006752 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 655816006753 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 655816006754 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 655816006755 E3 interaction surface; other site 655816006756 lipoyl attachment site [posttranslational modification]; other site 655816006757 e3 binding domain; Region: E3_binding; pfam02817 655816006758 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 655816006759 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 655816006760 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 655816006761 alpha subunit interface [polypeptide binding]; other site 655816006762 TPP binding site [chemical binding]; other site 655816006763 heterodimer interface [polypeptide binding]; other site 655816006764 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 655816006765 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 655816006766 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 655816006767 tetramer interface [polypeptide binding]; other site 655816006768 TPP-binding site [chemical binding]; other site 655816006769 heterodimer interface [polypeptide binding]; other site 655816006770 phosphorylation loop region [posttranslational modification] 655816006771 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 655816006772 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816006773 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655816006774 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 655816006775 Acetokinase family; Region: Acetate_kinase; cl01029 655816006776 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 655816006777 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 655816006778 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 655816006779 NAD binding site [chemical binding]; other site 655816006780 Phe binding site; other site 655816006781 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 655816006782 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 655816006783 acetaldehyde dehydrogenase (acetylating); Region: ac_ald_DH_ac; TIGR03215 655816006784 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 655816006785 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 655816006786 putative active site [active] 655816006787 heme pocket [chemical binding]; other site 655816006788 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 655816006789 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816006790 Walker A motif; other site 655816006791 ATP binding site [chemical binding]; other site 655816006792 Walker B motif; other site 655816006793 arginine finger; other site 655816006794 Helix-turn-helix domains; Region: HTH; cl00088 655816006795 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 655816006796 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 655816006797 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 655816006798 tetramer interface [polypeptide binding]; other site 655816006799 active site 655816006800 Mg2+/Mn2+ binding site [ion binding]; other site 655816006801 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 655816006802 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 655816006803 dimer interface [polypeptide binding]; other site 655816006804 Citrate synthase; Region: Citrate_synt; pfam00285 655816006805 active site 655816006806 coenzyme A binding site [chemical binding]; other site 655816006807 citrylCoA binding site [chemical binding]; other site 655816006808 oxalacetate/citrate binding site [chemical binding]; other site 655816006809 catalytic triad [active] 655816006810 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 655816006811 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 655816006812 FAD binding site [chemical binding]; other site 655816006813 homotetramer interface [polypeptide binding]; other site 655816006814 substrate binding pocket [chemical binding]; other site 655816006815 catalytic base [active] 655816006816 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 655816006817 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816006818 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 655816006819 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 655816006820 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 655816006821 dimer interface [polypeptide binding]; other site 655816006822 active site 655816006823 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 655816006824 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 655816006825 active site 655816006826 catalytic site [active] 655816006827 metal binding site [ion binding]; metal-binding site 655816006828 dimer interface [polypeptide binding]; other site 655816006829 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 655816006830 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 655816006831 active site 655816006832 metal binding site [ion binding]; metal-binding site 655816006833 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 655816006834 putative active site [active] 655816006835 putative FMN binding site [chemical binding]; other site 655816006836 putative substrate binding site [chemical binding]; other site 655816006837 putative catalytic residue [active] 655816006838 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 655816006839 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816006840 active site 655816006841 phosphorylation site [posttranslational modification] 655816006842 intermolecular recognition site; other site 655816006843 dimerization interface [polypeptide binding]; other site 655816006844 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 655816006845 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 655816006846 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 655816006847 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 655816006848 DNA repair protein RecN; Region: recN; TIGR00634 655816006849 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 655816006850 Walker A/P-loop; other site 655816006851 ATP binding site [chemical binding]; other site 655816006852 Q-loop/lid; other site 655816006853 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 655816006854 ABC transporter signature motif; other site 655816006855 Walker B; other site 655816006856 D-loop; other site 655816006857 H-loop/switch region; other site 655816006858 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 655816006859 arginine repressor; Provisional; Region: PRK04280 655816006860 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 655816006861 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 655816006862 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 655816006863 RNA binding surface [nucleotide binding]; other site 655816006864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 655816006865 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 655816006866 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 655816006867 TPP-binding site; other site 655816006868 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 655816006869 PYR/PP interface [polypeptide binding]; other site 655816006870 dimer interface [polypeptide binding]; other site 655816006871 TPP binding site [chemical binding]; other site 655816006872 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 655816006873 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 655816006874 substrate binding pocket [chemical binding]; other site 655816006875 chain length determination region; other site 655816006876 substrate-Mg2+ binding site; other site 655816006877 catalytic residues [active] 655816006878 aspartate-rich region 1; other site 655816006879 active site lid residues [active] 655816006880 aspartate-rich region 2; other site 655816006881 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 655816006882 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 655816006883 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 655816006884 generic binding surface II; other site 655816006885 generic binding surface I; other site 655816006886 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 655816006887 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 655816006888 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 655816006889 homodimer interface [polypeptide binding]; other site 655816006890 NADP binding site [chemical binding]; other site 655816006891 substrate binding site [chemical binding]; other site 655816006892 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 655816006893 putative RNA binding site [nucleotide binding]; other site 655816006894 Asp23 family; Region: Asp23; cl00574 655816006895 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 655816006896 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 655816006897 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 655816006898 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 655816006899 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 655816006900 carboxyltransferase (CT) interaction site; other site 655816006901 biotinylation site [posttranslational modification]; other site 655816006902 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 655816006903 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 655816006904 stage III sporulation protein AF; Region: spore_III_AF; TIGR02896 655816006905 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 655816006906 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 655816006907 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 655816006908 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 655816006909 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 655816006910 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 655816006911 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816006912 Walker A motif; other site 655816006913 ATP binding site [chemical binding]; other site 655816006914 Walker B motif; other site 655816006915 arginine finger; other site 655816006916 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 655816006917 elongation factor P; Validated; Region: PRK00529 655816006918 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 655816006919 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 655816006920 RNA binding site [nucleotide binding]; other site 655816006921 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 655816006922 RNA binding site [nucleotide binding]; other site 655816006923 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 655816006924 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 655816006925 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 655816006926 active site 655816006927 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 655816006928 trimer interface [polypeptide binding]; other site 655816006929 active site 655816006930 dimer interface [polypeptide binding]; other site 655816006931 Conserved membrane protein YqhR; Region: YqhR; pfam11085 655816006932 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 655816006933 kinase; Region: PLN02967 655816006934 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 655816006935 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 655816006936 active site 655816006937 nucleophile elbow; other site 655816006938 manganese transport transcriptional regulator; Provisional; Region: PRK03902 655816006939 Helix-turn-helix domains; Region: HTH; cl00088 655816006940 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 655816006941 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 655816006942 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 655816006943 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 655816006944 active site residue [active] 655816006945 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 655816006946 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 655816006947 tetramer interface [polypeptide binding]; other site 655816006948 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816006949 catalytic residue [active] 655816006950 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 655816006951 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 655816006952 tetramer interface [polypeptide binding]; other site 655816006953 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816006954 catalytic residue [active] 655816006955 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 655816006956 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 655816006957 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 655816006958 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 655816006959 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 655816006960 ATP binding site [chemical binding]; other site 655816006961 putative Mg++ binding site [ion binding]; other site 655816006962 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655816006963 nucleotide binding region [chemical binding]; other site 655816006964 ATP-dependent helicase HepA; Validated; Region: PRK04914 655816006965 ATP-binding site [chemical binding]; other site 655816006966 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 655816006967 Anti-repressor SinI; Region: SinI; pfam08671 655816006968 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655816006969 non-specific DNA binding site [nucleotide binding]; other site 655816006970 salt bridge; other site 655816006971 sequence-specific DNA binding site [nucleotide binding]; other site 655816006972 Anti-repressor SinI; Region: SinI; pfam08671 655816006973 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 655816006974 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 655816006975 Catalytic site [active] 655816006976 YqxM protein; Region: YqxM_for_SipW; TIGR04087 655816006977 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 655816006978 YqzE-like protein; Region: YqzE; pfam14038 655816006979 ComG operon protein 7; Region: ComGG; pfam14173 655816006980 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 655816006981 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 655816006982 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 655816006983 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 655816006984 Type II/IV secretion system protein; Region: T2SE; pfam00437 655816006985 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 655816006986 Walker A motif; other site 655816006987 ATP binding site [chemical binding]; other site 655816006988 Walker B motif; other site 655816006989 FOG: CBS domain [General function prediction only]; Region: COG0517 655816006990 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 655816006991 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 655816006992 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 655816006993 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 655816006994 Domain of unknown function DUF21; Region: DUF21; pfam01595 655816006995 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 655816006996 Transporter associated domain; Region: CorC_HlyC; cl08393 655816006997 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 655816006998 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 655816006999 ArsC family; Region: ArsC; pfam03960 655816007000 putative catalytic residues [active] 655816007001 thiol/disulfide switch; other site 655816007002 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 655816007003 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 655816007004 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 655816007005 Domain of unknown function DUF77; Region: DUF77; cl00307 655816007006 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 655816007007 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 655816007008 putative active site [active] 655816007009 Zn binding site [ion binding]; other site 655816007010 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 655816007011 Sulfatase; Region: Sulfatase; cl10460 655816007012 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 655816007013 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 655816007014 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 655816007015 Rhomboid family; Region: Rhomboid; cl11446 655816007016 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816007017 binding surface 655816007018 Tetratricopeptide repeat; Region: TPR_16; pfam13432 655816007019 TPR motif; other site 655816007020 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 655816007021 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 655816007022 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 655816007023 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 655816007024 proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675 655816007025 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14274 655816007026 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 655816007027 Walker A/P-loop; other site 655816007028 ATP binding site [chemical binding]; other site 655816007029 Q-loop/lid; other site 655816007030 ABC transporter signature motif; other site 655816007031 Walker B; other site 655816007032 D-loop; other site 655816007033 H-loop/switch region; other site 655816007034 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14248 655816007035 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 655816007036 Walker A/P-loop; other site 655816007037 ATP binding site [chemical binding]; other site 655816007038 Q-loop/lid; other site 655816007039 ABC transporter signature motif; other site 655816007040 Walker B; other site 655816007041 D-loop; other site 655816007042 H-loop/switch region; other site 655816007043 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 655816007044 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816007045 dimer interface [polypeptide binding]; other site 655816007046 conserved gate region; other site 655816007047 ABC-ATPase subunit interface; other site 655816007048 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 655816007049 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816007050 dimer interface [polypeptide binding]; other site 655816007051 conserved gate region; other site 655816007052 putative PBP binding loops; other site 655816007053 ABC-ATPase subunit interface; other site 655816007054 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 655816007055 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 655816007056 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 655816007057 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 655816007058 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 655816007059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816007060 putative substrate translocation pore; other site 655816007061 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 655816007062 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 655816007063 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 655816007064 Protein of unknown function (DUF456); Region: DUF456; cl01069 655816007065 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 655816007066 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 655816007067 putative peptidoglycan binding site; other site 655816007068 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 655816007069 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 655816007070 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 655816007071 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 655816007072 ferric uptake regulator; Provisional; Region: fur; PRK09462 655816007073 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 655816007074 metal binding site 2 [ion binding]; metal-binding site 655816007075 putative DNA binding helix; other site 655816007076 metal binding site 1 [ion binding]; metal-binding site 655816007077 dimer interface [polypeptide binding]; other site 655816007078 structural Zn2+ binding site [ion binding]; other site 655816007079 Uncharacterized conserved protein [Function unknown]; Region: COG1284 655816007080 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 655816007081 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 655816007082 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 655816007083 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 655816007084 endonuclease IV; Provisional; Region: PRK01060 655816007085 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 655816007086 AP (apurinic/apyrimidinic) site pocket; other site 655816007087 DNA interaction; other site 655816007088 Metal-binding active site; metal-binding site 655816007089 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 655816007090 DEAD-like helicases superfamily; Region: DEXDc; smart00487 655816007091 ATP binding site [chemical binding]; other site 655816007092 Mg++ binding site [ion binding]; other site 655816007093 motif III; other site 655816007094 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655816007095 nucleotide binding region [chemical binding]; other site 655816007096 ATP-binding site [chemical binding]; other site 655816007097 YqfQ-like protein; Region: YqfQ; pfam14181 655816007098 LytB protein; Region: LYTB; cl00507 655816007099 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 655816007100 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 655816007101 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 655816007102 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 655816007103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816007104 Cytochrome c; Region: Cytochrom_C; cl11414 655816007105 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 655816007106 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 655816007107 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 655816007108 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655816007109 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 655816007110 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655816007111 DNA binding residues [nucleotide binding] 655816007112 DNA primase; Validated; Region: dnaG; PRK05667 655816007113 CHC2 zinc finger; Region: zf-CHC2; cl15369 655816007114 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 655816007115 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 655816007116 active site 655816007117 metal binding site [ion binding]; metal-binding site 655816007118 interdomain interaction site; other site 655816007119 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 655816007120 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 655816007121 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 655816007122 Helix-turn-helix domains; Region: HTH; cl00088 655816007123 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 655816007124 FOG: CBS domain [General function prediction only]; Region: COG0517 655816007125 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 655816007126 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 655816007127 dimer interface [polypeptide binding]; other site 655816007128 motif 1; other site 655816007129 active site 655816007130 motif 2; other site 655816007131 motif 3; other site 655816007132 Recombination protein O N terminal; Region: RecO_N; cl15812 655816007133 DNA repair protein RecO; Region: reco; TIGR00613 655816007134 Recombination protein O C terminal; Region: RecO_C; pfam02565 655816007135 YqzL-like protein; Region: YqzL; pfam14006 655816007136 GTPase Era; Reviewed; Region: era; PRK00089 655816007137 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 655816007138 G1 box; other site 655816007139 GTP/Mg2+ binding site [chemical binding]; other site 655816007140 Switch I region; other site 655816007141 G2 box; other site 655816007142 Switch II region; other site 655816007143 G3 box; other site 655816007144 G4 box; other site 655816007145 G5 box; other site 655816007146 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 655816007147 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 655816007148 active site 655816007149 catalytic motif [active] 655816007150 Zn binding site [ion binding]; other site 655816007151 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 655816007152 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 655816007153 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 655816007154 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 655816007155 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 655816007156 Zn2+ binding site [ion binding]; other site 655816007157 Mg2+ binding site [ion binding]; other site 655816007158 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 655816007159 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816007160 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 655816007161 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 655816007162 YabP family; Region: YabP; cl06766 655816007163 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 655816007164 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 655816007165 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 655816007166 dimer interface [polypeptide binding]; other site 655816007167 active site residues [active] 655816007168 GatB domain; Region: GatB_Yqey; cl11497 655816007169 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 655816007170 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 655816007171 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 655816007172 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 655816007173 radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089 655816007174 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 655816007175 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655816007176 FeS/SAM binding site; other site 655816007177 TRAM domain; Region: TRAM; cl01282 655816007178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 655816007179 RNA methyltransferase, RsmE family; Region: TIGR00046 655816007180 ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406 655816007181 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816007182 S-adenosylmethionine binding site [chemical binding]; other site 655816007183 chaperone protein DnaJ; Provisional; Region: PRK14280 655816007184 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 655816007185 HSP70 interaction site [polypeptide binding]; other site 655816007186 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 655816007187 substrate binding site [polypeptide binding]; other site 655816007188 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 655816007189 Zn binding sites [ion binding]; other site 655816007190 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 655816007191 dimer interface [polypeptide binding]; other site 655816007192 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 655816007193 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 655816007194 dimer interface [polypeptide binding]; other site 655816007195 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 655816007196 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 655816007197 Helix-turn-helix domains; Region: HTH; cl00088 655816007198 HrcA protein C terminal domain; Region: HrcA; pfam01628 655816007199 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 655816007200 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655816007201 FeS/SAM binding site; other site 655816007202 HemN C-terminal domain; Region: HemN_C; pfam06969 655816007203 GTP-binding protein LepA; Provisional; Region: PRK05433 655816007204 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 655816007205 G1 box; other site 655816007206 putative GEF interaction site [polypeptide binding]; other site 655816007207 GTP/Mg2+ binding site [chemical binding]; other site 655816007208 Switch I region; other site 655816007209 G2 box; other site 655816007210 G3 box; other site 655816007211 Switch II region; other site 655816007212 G4 box; other site 655816007213 G5 box; other site 655816007214 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 655816007215 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 655816007216 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 655816007217 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 655816007218 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 655816007219 stage II sporulation protein P; Region: spore_II_P; TIGR02867 655816007220 Germination protease; Region: Peptidase_A25; cl04057 655816007221 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 655816007222 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 655816007223 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 655816007224 YqzM-like protein; Region: YqzM; pfam14141 655816007225 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 655816007226 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 655816007227 Competence protein; Region: Competence; cl00471 655816007228 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 655816007229 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 655816007230 catalytic motif [active] 655816007231 Zn binding site [ion binding]; other site 655816007232 SLBB domain; Region: SLBB; pfam10531 655816007233 comEA protein; Region: comE; TIGR01259 655816007234 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 655816007235 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816007236 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 655816007237 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 655816007238 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816007239 S-adenosylmethionine binding site [chemical binding]; other site 655816007240 Oligomerisation domain; Region: Oligomerisation; cl00519 655816007241 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 655816007242 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 655816007243 Zn2+ binding site [ion binding]; other site 655816007244 Mg2+ binding site [ion binding]; other site 655816007245 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 655816007246 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 655816007247 active site 655816007248 (T/H)XGH motif; other site 655816007249 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 655816007250 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 655816007251 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 655816007252 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 655816007253 shikimate binding site; other site 655816007254 NAD(P) binding site [chemical binding]; other site 655816007255 GTPase YqeH; Provisional; Region: PRK13796 655816007256 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 655816007257 GTP/Mg2+ binding site [chemical binding]; other site 655816007258 G4 box; other site 655816007259 G5 box; other site 655816007260 G1 box; other site 655816007261 Switch I region; other site 655816007262 G2 box; other site 655816007263 G3 box; other site 655816007264 Switch II region; other site 655816007265 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 655816007266 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816007267 active site 655816007268 motif I; other site 655816007269 motif II; other site 655816007270 Sporulation inhibitor A; Region: Sda; pfam08970 655816007271 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 655816007272 active site 655816007273 catalytic triad [active] 655816007274 oxyanion hole [active] 655816007275 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 655816007276 amidase catalytic site [active] 655816007277 Zn binding residues [ion binding]; other site 655816007278 substrate binding site [chemical binding]; other site 655816007279 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 655816007280 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 655816007281 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 655816007282 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816007283 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 655816007284 sporulation sigma factor SigK; Reviewed; Region: PRK05803 655816007285 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655816007286 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655816007287 DNA binding residues [nucleotide binding] 655816007288 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 655816007289 catalytic residues [active] 655816007290 catalytic nucleophile [active] 655816007291 fumarate hydratase; Reviewed; Region: fumC; PRK00485 655816007292 Class II fumarases; Region: Fumarase_classII; cd01362 655816007293 active site 655816007294 tetramer interface [polypeptide binding]; other site 655816007295 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655816007296 Helix-turn-helix domains; Region: HTH; cl00088 655816007297 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 655816007298 putative dimerization interface [polypeptide binding]; other site 655816007299 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 655816007300 catalytic nucleophile [active] 655816007301 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 655816007302 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 655816007303 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 655816007304 FMN binding site [chemical binding]; other site 655816007305 substrate binding site [chemical binding]; other site 655816007306 putative catalytic residue [active] 655816007307 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816007308 Helix-turn-helix domains; Region: HTH; cl00088 655816007309 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816007310 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 655816007311 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 655816007312 dimerization interface [polypeptide binding]; other site 655816007313 putative DNA binding site [nucleotide binding]; other site 655816007314 putative Zn2+ binding site [ion binding]; other site 655816007315 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 655816007316 dimer interface [polypeptide binding]; other site 655816007317 FMN binding site [chemical binding]; other site 655816007318 NADPH bind site [chemical binding]; other site 655816007319 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 655816007320 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655816007321 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 655816007322 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655816007323 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 655816007324 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 655816007325 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816007326 NAD(P) binding site [chemical binding]; other site 655816007327 active site 655816007328 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 655816007329 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 655816007330 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 655816007331 DNA binding residues [nucleotide binding] 655816007332 dimer interface [polypeptide binding]; other site 655816007333 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 655816007334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816007335 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816007336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816007337 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 655816007338 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 655816007339 Transcriptional regulators [Transcription]; Region: FadR; COG2186 655816007340 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816007341 DNA-binding site [nucleotide binding]; DNA binding site 655816007342 FCD domain; Region: FCD; cl11656 655816007343 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 655816007344 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 655816007345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816007346 D-galactonate transporter; Region: 2A0114; TIGR00893 655816007347 putative substrate translocation pore; other site 655816007348 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 655816007349 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816007350 NAD(P) binding site [chemical binding]; other site 655816007351 active site 655816007352 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 655816007353 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 655816007354 PYR/PP interface [polypeptide binding]; other site 655816007355 dimer interface [polypeptide binding]; other site 655816007356 TPP binding site [chemical binding]; other site 655816007357 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 655816007358 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 655816007359 TPP-binding site [chemical binding]; other site 655816007360 dimer interface [polypeptide binding]; other site 655816007361 Protein of unknown function, DUF606; Region: DUF606; cl01273 655816007362 Protein of unknown function, DUF606; Region: DUF606; cl01273 655816007363 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 655816007364 dimerization interface [polypeptide binding]; other site 655816007365 putative DNA binding site [nucleotide binding]; other site 655816007366 putative Zn2+ binding site [ion binding]; other site 655816007367 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 655816007368 Protein of unknown function (DUF419); Region: DUF419; cl15265 655816007369 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 655816007370 active site 655816007371 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 655816007372 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; cl15373 655816007373 YodA lipocalin-like domain; Region: YodA; cl01365 655816007374 Bacterial SH3 domain; Region: SH3_3; cl02551 655816007375 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 655816007376 Bacterial SH3 domain; Region: SH3_3; cl02551 655816007377 Coat F domain; Region: Coat_F; cl15836 655816007378 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 655816007379 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 655816007380 NAD binding site [chemical binding]; other site 655816007381 catalytic Zn binding site [ion binding]; other site 655816007382 structural Zn binding site [ion binding]; other site 655816007383 Coat F domain; Region: Coat_F; cl15836 655816007384 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 655816007385 dimerization domain swap beta strand [polypeptide binding]; other site 655816007386 regulatory protein interface [polypeptide binding]; other site 655816007387 regulatory phosphorylation site [posttranslational modification]; other site 655816007388 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 655816007389 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 655816007390 active site 655816007391 catalytic tetrad [active] 655816007392 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 655816007393 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 655816007394 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655816007395 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655816007396 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 655816007397 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 655816007398 DNA binding residues [nucleotide binding] 655816007399 putative dimer interface [polypeptide binding]; other site 655816007400 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 655816007401 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 655816007402 DNA binding residues [nucleotide binding] 655816007403 putative dimer interface [polypeptide binding]; other site 655816007404 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 655816007405 Cupin domain; Region: Cupin_2; cl09118 655816007406 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 655816007407 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 655816007408 putative NAD(P) binding site [chemical binding]; other site 655816007409 putative substrate binding site [chemical binding]; other site 655816007410 catalytic Zn binding site [ion binding]; other site 655816007411 structural Zn binding site [ion binding]; other site 655816007412 dimer interface [polypeptide binding]; other site 655816007413 intracellular protease, PfpI family; Region: PfpI; TIGR01382 655816007414 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 655816007415 proposed catalytic triad [active] 655816007416 conserved cys residue [active] 655816007417 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 655816007418 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 655816007419 substrate binding [chemical binding]; other site 655816007420 active site 655816007421 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 655816007422 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 655816007423 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 655816007424 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 655816007425 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 655816007426 active site 655816007427 phosphorylation site [posttranslational modification] 655816007428 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 655816007429 active pocket/dimerization site; other site 655816007430 active site 655816007431 phosphorylation site [posttranslational modification] 655816007432 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 655816007433 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816007434 Walker A motif; other site 655816007435 ATP binding site [chemical binding]; other site 655816007436 Walker B motif; other site 655816007437 arginine finger; other site 655816007438 Transcriptional antiterminator [Transcription]; Region: COG3933 655816007439 PRD domain; Region: PRD; cl15445 655816007440 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 655816007441 active pocket/dimerization site; other site 655816007442 active site 655816007443 phosphorylation site [posttranslational modification] 655816007444 PRD domain; Region: PRD; cl15445 655816007445 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 655816007446 LysE type translocator; Region: LysE; cl00565 655816007447 Predicted transcriptional regulators [Transcription]; Region: COG1378 655816007448 Helix-turn-helix domains; Region: HTH; cl00088 655816007449 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 655816007450 C-terminal domain interface [polypeptide binding]; other site 655816007451 sugar binding site [chemical binding]; other site 655816007452 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 655816007453 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655816007454 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655816007455 DNA binding residues [nucleotide binding] 655816007456 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 655816007457 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 655816007458 OpgC protein; Region: OpgC_C; cl00792 655816007459 Acyltransferase family; Region: Acyl_transf_3; pfam01757 655816007460 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 655816007461 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 655816007462 catalytic triad [active] 655816007463 catalytic triad [active] 655816007464 oxyanion hole [active] 655816007465 YrhK-like protein; Region: YrhK; pfam14145 655816007466 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 655816007467 Cytochrome P450; Region: p450; pfam00067 655816007468 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 655816007469 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 655816007470 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 655816007471 FAD binding pocket [chemical binding]; other site 655816007472 FAD binding motif [chemical binding]; other site 655816007473 catalytic residues [active] 655816007474 NAD binding pocket [chemical binding]; other site 655816007475 phosphate binding motif [ion binding]; other site 655816007476 beta-alpha-beta structure motif; other site 655816007477 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655816007478 Helix-turn-helix domains; Region: HTH; cl00088 655816007479 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816007480 S-adenosylmethionine binding site [chemical binding]; other site 655816007481 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 655816007482 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 655816007483 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 655816007484 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 655816007485 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 655816007486 catalytic loop [active] 655816007487 iron binding site [ion binding]; other site 655816007488 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 655816007489 4Fe-4S binding domain; Region: Fer4; cl02805 655816007490 4Fe-4S binding domain; Region: Fer4; cl02805 655816007491 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 655816007492 [4Fe-4S] binding site [ion binding]; other site 655816007493 molybdopterin cofactor binding site; other site 655816007494 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 655816007495 molybdopterin cofactor binding site; other site 655816007496 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 655816007497 YrhC-like protein; Region: YrhC; pfam14143 655816007498 cystathionine beta-lyase; Provisional; Region: PRK07671 655816007499 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 655816007500 homodimer interface [polypeptide binding]; other site 655816007501 substrate-cofactor binding pocket; other site 655816007502 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816007503 catalytic residue [active] 655816007504 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 655816007505 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 655816007506 dimer interface [polypeptide binding]; other site 655816007507 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816007508 catalytic residue [active] 655816007509 5'-methylthioadenosine nucleosidase; Region: PLN02584 655816007510 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 655816007511 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 655816007512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816007513 S-adenosylmethionine binding site [chemical binding]; other site 655816007514 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 655816007515 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 655816007516 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 655816007517 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 655816007518 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 655816007519 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 655816007520 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 655816007521 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 655816007522 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 655816007523 ATP-binding site [chemical binding]; other site 655816007524 Sugar specificity; other site 655816007525 Pyrimidine base specificity; other site 655816007526 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 655816007527 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 655816007528 Peptidase family U32; Region: Peptidase_U32; cl03113 655816007529 Peptidase family U32; Region: Peptidase_U32; cl03113 655816007530 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 655816007531 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816007532 S-adenosylmethionine binding site [chemical binding]; other site 655816007533 YceG-like family; Region: YceG; pfam02618 655816007534 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 655816007535 dimerization interface [polypeptide binding]; other site 655816007536 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 655816007537 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 655816007538 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 655816007539 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 655816007540 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 655816007541 motif 1; other site 655816007542 active site 655816007543 motif 2; other site 655816007544 motif 3; other site 655816007545 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 655816007546 DHHA1 domain; Region: DHHA1; pfam02272 655816007547 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 655816007548 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 655816007549 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 655816007550 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 655816007551 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 655816007552 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816007553 Family description; Region: UvrD_C_2; cl15862 655816007554 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816007555 binding surface 655816007556 TPR motif; other site 655816007557 TPR repeat; Region: TPR_11; pfam13414 655816007558 TPR repeat; Region: TPR_11; pfam13414 655816007559 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816007560 binding surface 655816007561 TPR motif; other site 655816007562 TPR repeat; Region: TPR_11; pfam13414 655816007563 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 655816007564 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 655816007565 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 655816007566 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 655816007567 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 655816007568 catalytic residue [active] 655816007569 Predicted transcriptional regulator [Transcription]; Region: COG1959 655816007570 Helix-turn-helix domains; Region: HTH; cl00088 655816007571 recombination factor protein RarA; Reviewed; Region: PRK13342 655816007572 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816007573 Walker A motif; other site 655816007574 ATP binding site [chemical binding]; other site 655816007575 Walker B motif; other site 655816007576 arginine finger; other site 655816007577 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 655816007578 Integrase core domain; Region: rve; cl01316 655816007579 Integrase core domain; Region: rve_3; cl15866 655816007580 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 655816007581 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 655816007582 putative ATP binding site [chemical binding]; other site 655816007583 putative substrate interface [chemical binding]; other site 655816007584 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 655816007585 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 655816007586 dimer interface [polypeptide binding]; other site 655816007587 anticodon binding site; other site 655816007588 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 655816007589 homodimer interface [polypeptide binding]; other site 655816007590 motif 1; other site 655816007591 active site 655816007592 motif 2; other site 655816007593 GAD domain; Region: GAD; pfam02938 655816007594 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 655816007595 motif 3; other site 655816007596 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 655816007597 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 655816007598 dimer interface [polypeptide binding]; other site 655816007599 motif 1; other site 655816007600 active site 655816007601 motif 2; other site 655816007602 motif 3; other site 655816007603 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 655816007604 anticodon binding site; other site 655816007605 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 655816007606 Bacterial SH3 domain; Region: SH3_3; cl02551 655816007607 Bacterial SH3 domain; Region: SH3_3; cl02551 655816007608 Bacterial SH3 domain; Region: SH3_3; cl02551 655816007609 Bacterial SH3 domain; Region: SH3_3; cl02551 655816007610 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 655816007611 active site 655816007612 metal binding site [ion binding]; metal-binding site 655816007613 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 655816007614 putative active site [active] 655816007615 dimerization interface [polypeptide binding]; other site 655816007616 putative tRNAtyr binding site [nucleotide binding]; other site 655816007617 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 655816007618 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 655816007619 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 655816007620 synthetase active site [active] 655816007621 NTP binding site [chemical binding]; other site 655816007622 metal binding site [ion binding]; metal-binding site 655816007623 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 655816007624 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 655816007625 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 655816007626 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 655816007627 active site 655816007628 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 655816007629 DHH family; Region: DHH; pfam01368 655816007630 DHHA1 domain; Region: DHHA1; pfam02272 655816007631 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 655816007632 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 655816007633 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 655816007634 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 655816007635 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 655816007636 Protein export membrane protein; Region: SecD_SecF; cl14618 655816007637 Protein export membrane protein; Region: SecD_SecF; cl14618 655816007638 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 655816007639 stage V sporulation protein B; Region: spore_V_B; TIGR02900 655816007640 MatE; Region: MatE; cl10513 655816007641 MatE; Region: MatE; cl10513 655816007642 Protein of unknown function (DUF421); Region: DUF421; cl00990 655816007643 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 655816007644 Preprotein translocase subunit; Region: YajC; cl00806 655816007645 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 655816007646 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 655816007647 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 655816007648 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 655816007649 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 655816007650 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 655816007651 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816007652 Walker A motif; other site 655816007653 ATP binding site [chemical binding]; other site 655816007654 Walker B motif; other site 655816007655 arginine finger; other site 655816007656 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 655816007657 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 655816007658 RuvA N terminal domain; Region: RuvA_N; pfam01330 655816007659 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 655816007660 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 655816007661 BofC C-terminal domain; Region: BofC_C; pfam08955 655816007662 polyol permease family; Region: 2A0118; TIGR00897 655816007663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816007664 putative substrate translocation pore; other site 655816007665 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 655816007666 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816007667 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 655816007668 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 655816007669 active site 655816007670 substrate binding site [chemical binding]; other site 655816007671 ATP binding site [chemical binding]; other site 655816007672 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 655816007673 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 655816007674 Transcriptional regulator; Region: Transcrip_reg; cl00361 655816007675 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 655816007676 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 655816007677 putative peptidoglycan binding site; other site 655816007678 Quinolinate synthetase A protein; Region: NadA; cl00420 655816007679 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 655816007680 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 655816007681 dimerization interface [polypeptide binding]; other site 655816007682 active site 655816007683 L-aspartate oxidase; Provisional; Region: PRK08071 655816007684 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816007685 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 655816007686 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 655816007687 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 655816007688 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 655816007689 catalytic residue [active] 655816007690 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 655816007691 Helix-turn-helix domains; Region: HTH; cl00088 655816007692 3H domain; Region: 3H; pfam02829 655816007693 prephenate dehydratase; Provisional; Region: PRK11898 655816007694 Prephenate dehydratase; Region: PDT; pfam00800 655816007695 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 655816007696 putative L-Phe binding site [chemical binding]; other site 655816007697 hypothetical protein; Provisional; Region: PRK04435 655816007698 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 655816007699 GTPase CgtA; Reviewed; Region: obgE; PRK12297 655816007700 GTP1/OBG; Region: GTP1_OBG; pfam01018 655816007701 Obg GTPase; Region: Obg; cd01898 655816007702 G1 box; other site 655816007703 GTP/Mg2+ binding site [chemical binding]; other site 655816007704 Switch I region; other site 655816007705 G2 box; other site 655816007706 G3 box; other site 655816007707 Switch II region; other site 655816007708 G4 box; other site 655816007709 G5 box; other site 655816007710 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 655816007711 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 655816007712 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 655816007713 Protein of unknown function (DUF464); Region: DUF464; cl01080 655816007714 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 655816007715 L21 leader; ribosomal protein gene, untranslated leader autoregulatory structure; BSUW23_misc_RNA_43 655816007716 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 655816007717 active site 655816007718 putative substrate binding region [chemical binding]; other site 655816007719 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 655816007720 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 655816007721 septum site-determining protein MinD; Region: minD_bact; TIGR01968 655816007722 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 655816007723 Switch I; other site 655816007724 Switch II; other site 655816007725 septum formation inhibitor; Reviewed; Region: minC; PRK00513 655816007726 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 655816007727 rod shape-determining protein MreD; Region: MreD; cl01087 655816007728 rod shape-determining protein MreC; Region: mreC; TIGR00219 655816007729 rod shape-determining protein MreC; Region: MreC; pfam04085 655816007730 rod shape-determining protein MreB; Provisional; Region: PRK13927 655816007731 Cell division protein FtsA; Region: FtsA; cl11496 655816007732 hypothetical protein; Reviewed; Region: PRK00024 655816007733 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 655816007734 MPN+ (JAMM) motif; other site 655816007735 Zinc-binding site [ion binding]; other site 655816007736 Maf-like protein; Region: Maf; pfam02545 655816007737 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 655816007738 active site 655816007739 dimer interface [polypeptide binding]; other site 655816007740 Sporulation related domain; Region: SPOR; cl10051 655816007741 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 655816007742 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 655816007743 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 655816007744 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 655816007745 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 655816007746 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 655816007747 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 655816007748 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 655816007749 active site 655816007750 HIGH motif; other site 655816007751 nucleotide binding site [chemical binding]; other site 655816007752 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 655816007753 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 655816007754 active site 655816007755 KMSKS motif; other site 655816007756 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 655816007757 tRNA binding surface [nucleotide binding]; other site 655816007758 anticodon binding site; other site 655816007759 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 655816007760 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 655816007761 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 655816007762 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 655816007763 putative peptidoglycan binding site; other site 655816007764 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 655816007765 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 655816007766 inhibitor-cofactor binding pocket; inhibition site 655816007767 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816007768 catalytic residue [active] 655816007769 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 655816007770 dimer interface [polypeptide binding]; other site 655816007771 active site 655816007772 Schiff base residues; other site 655816007773 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 655816007774 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 655816007775 active site 655816007776 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 655816007777 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 655816007778 domain interfaces; other site 655816007779 active site 655816007780 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 655816007781 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 655816007782 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 655816007783 tRNA; other site 655816007784 putative tRNA binding site [nucleotide binding]; other site 655816007785 putative NADP binding site [chemical binding]; other site 655816007786 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 655816007787 Predicted GTPase [General function prediction only]; Region: COG0218 655816007788 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 655816007789 G1 box; other site 655816007790 GTP/Mg2+ binding site [chemical binding]; other site 655816007791 Switch I region; other site 655816007792 G2 box; other site 655816007793 G3 box; other site 655816007794 Switch II region; other site 655816007795 G4 box; other site 655816007796 G5 box; other site 655816007797 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 655816007798 Found in ATP-dependent protease La (LON); Region: LON; smart00464 655816007799 Found in ATP-dependent protease La (LON); Region: LON; smart00464 655816007800 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816007801 Walker A motif; other site 655816007802 ATP binding site [chemical binding]; other site 655816007803 Walker B motif; other site 655816007804 arginine finger; other site 655816007805 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 655816007806 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 655816007807 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816007808 Walker A motif; other site 655816007809 ATP binding site [chemical binding]; other site 655816007810 Walker B motif; other site 655816007811 arginine finger; other site 655816007812 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 655816007813 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 655816007814 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 655816007815 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816007816 Walker A motif; other site 655816007817 ATP binding site [chemical binding]; other site 655816007818 Walker B motif; other site 655816007819 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 655816007820 trigger factor; Provisional; Region: tig; PRK01490 655816007821 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 655816007822 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 655816007823 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816007824 binding surface 655816007825 TPR motif; other site 655816007826 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 655816007827 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 655816007828 substrate binding site [chemical binding]; other site 655816007829 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 655816007830 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 655816007831 substrate binding site [chemical binding]; other site 655816007832 ligand binding site [chemical binding]; other site 655816007833 tartrate dehydrogenase; Provisional; Region: PRK08194 655816007834 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 655816007835 2-isopropylmalate synthase; Validated; Region: PRK00915 655816007836 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 655816007837 active site 655816007838 catalytic residues [active] 655816007839 metal binding site [ion binding]; metal-binding site 655816007840 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 655816007841 ketol-acid reductoisomerase; Provisional; Region: PRK05479 655816007842 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816007843 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 655816007844 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 655816007845 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 655816007846 putative valine binding site [chemical binding]; other site 655816007847 dimer interface [polypeptide binding]; other site 655816007848 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 655816007849 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 655816007850 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 655816007851 PYR/PP interface [polypeptide binding]; other site 655816007852 dimer interface [polypeptide binding]; other site 655816007853 TPP binding site [chemical binding]; other site 655816007854 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 655816007855 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 655816007856 TPP-binding site [chemical binding]; other site 655816007857 dimer interface [polypeptide binding]; other site 655816007858 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 655816007859 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816007860 Coenzyme A binding pocket [chemical binding]; other site 655816007861 cyclically-permuted mutatrotase family protein; Region: mutarot_permut; TIGR03548 655816007862 Kelch motif; Region: Kelch_1; cl02701 655816007863 Kelch motif; Region: Kelch_1; cl02701 655816007864 Kelch motif; Region: Kelch_1; cl02701 655816007865 Heat induced stress protein YflT; Region: YflT; pfam11181 655816007866 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 655816007867 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 655816007868 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 655816007869 active site 655816007870 metal binding site [ion binding]; metal-binding site 655816007871 homotetramer interface [polypeptide binding]; other site 655816007872 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 655816007873 active site 655816007874 dimerization interface [polypeptide binding]; other site 655816007875 ribonuclease PH; Reviewed; Region: rph; PRK00173 655816007876 Ribonuclease PH; Region: RNase_PH_bact; cd11362 655816007877 hexamer interface [polypeptide binding]; other site 655816007878 active site 655816007879 Spore germination protein [General function prediction only]; Region: COG5401 655816007880 Sporulation and spore germination; Region: Germane; cl11253 655816007881 Sporulation and spore germination; Region: Germane; cl11253 655816007882 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 655816007883 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816007884 Helix-turn-helix domains; Region: HTH; cl00088 655816007885 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655816007886 DNA binding residues [nucleotide binding] 655816007887 dimerization interface [polypeptide binding]; other site 655816007888 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 655816007889 active site 655816007890 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 655816007891 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 655816007892 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 655816007893 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 655816007894 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816007895 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 655816007896 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 655816007897 putative Iron-sulfur protein interface [polypeptide binding]; other site 655816007898 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 655816007899 proximal heme binding site [chemical binding]; other site 655816007900 distal heme binding site [chemical binding]; other site 655816007901 putative dimer interface [polypeptide binding]; other site 655816007902 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 655816007903 aspartate kinase; Reviewed; Region: PRK06635 655816007904 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 655816007905 putative nucleotide binding site [chemical binding]; other site 655816007906 putative catalytic residues [active] 655816007907 putative Mg ion binding site [ion binding]; other site 655816007908 putative aspartate binding site [chemical binding]; other site 655816007909 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 655816007910 putative allosteric regulatory site; other site 655816007911 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 655816007912 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 655816007913 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 655816007914 GIY-YIG motif/motif A; other site 655816007915 active site 655816007916 catalytic site [active] 655816007917 putative DNA binding site [nucleotide binding]; other site 655816007918 metal binding site [ion binding]; metal-binding site 655816007919 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 655816007920 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 655816007921 catalytic residues [active] 655816007922 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 655816007923 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 655816007924 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 655816007925 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 655816007926 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 655816007927 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 655816007928 Ligand binding site [chemical binding]; other site 655816007929 Electron transfer flavoprotein domain; Region: ETF; pfam01012 655816007930 enoyl-CoA hydratase; Provisional; Region: PRK07658 655816007931 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 655816007932 substrate binding site [chemical binding]; other site 655816007933 oxyanion hole (OAH) forming residues; other site 655816007934 trimer interface [polypeptide binding]; other site 655816007935 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655816007936 Helix-turn-helix domains; Region: HTH; cl00088 655816007937 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 655816007938 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 655816007939 AMP-binding enzyme; Region: AMP-binding; cl15778 655816007940 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 655816007941 Predicted membrane protein [Function unknown]; Region: COG3766 655816007942 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 655816007943 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 655816007944 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 655816007945 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 655816007946 Walker A/P-loop; other site 655816007947 ATP binding site [chemical binding]; other site 655816007948 Q-loop/lid; other site 655816007949 ABC transporter signature motif; other site 655816007950 Walker B; other site 655816007951 D-loop; other site 655816007952 H-loop/switch region; other site 655816007953 Smr domain; Region: Smr; cl02619 655816007954 hypothetical protein; Provisional; Region: PRK08609 655816007955 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 655816007956 active site 655816007957 primer binding site [nucleotide binding]; other site 655816007958 NTP binding site [chemical binding]; other site 655816007959 metal binding triad [ion binding]; metal-binding site 655816007960 Colicin V production protein; Region: Colicin_V; cl00567 655816007961 Cell division protein ZapA; Region: ZapA; cl01146 655816007962 ribonuclease HIII; Provisional; Region: PRK00996 655816007963 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 655816007964 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 655816007965 RNA/DNA hybrid binding site [nucleotide binding]; other site 655816007966 active site 655816007967 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 655816007968 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 655816007969 putative tRNA-binding site [nucleotide binding]; other site 655816007970 B3/4 domain; Region: B3_4; cl11458 655816007971 tRNA synthetase B5 domain; Region: B5; cl08394 655816007972 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 655816007973 dimer interface [polypeptide binding]; other site 655816007974 motif 1; other site 655816007975 motif 3; other site 655816007976 motif 2; other site 655816007977 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 655816007978 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 655816007979 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 655816007980 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 655816007981 dimer interface [polypeptide binding]; other site 655816007982 motif 1; other site 655816007983 active site 655816007984 motif 2; other site 655816007985 motif 3; other site 655816007986 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 655816007987 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 655816007988 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 655816007989 Small, acid-soluble spore protein I; Region: SSPI; cl07940 655816007990 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 655816007991 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 655816007992 active site 655816007993 catalytic site [active] 655816007994 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 655816007995 FAD binding domain; Region: FAD_binding_4; pfam01565 655816007996 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 655816007997 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 655816007998 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 655816007999 Cysteine-rich domain; Region: CCG; pfam02754 655816008000 Cysteine-rich domain; Region: CCG; pfam02754 655816008001 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 655816008002 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 655816008003 active site 655816008004 metal binding site [ion binding]; metal-binding site 655816008005 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 655816008006 Carbon starvation protein CstA; Region: CstA; pfam02554 655816008007 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 655816008008 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 655816008009 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 655816008010 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 655816008011 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 655816008012 Helix-turn-helix domains; Region: HTH; cl00088 655816008013 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 655816008014 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 655816008015 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 655816008016 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816008017 putative PBP binding loops; other site 655816008018 dimer interface [polypeptide binding]; other site 655816008019 ABC-ATPase subunit interface; other site 655816008020 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 655816008021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816008022 dimer interface [polypeptide binding]; other site 655816008023 conserved gate region; other site 655816008024 putative PBP binding loops; other site 655816008025 ABC-ATPase subunit interface; other site 655816008026 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 655816008027 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 655816008028 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 655816008029 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 655816008030 active site 655816008031 metal binding site [ion binding]; metal-binding site 655816008032 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 655816008033 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816008034 active site 655816008035 motif I; other site 655816008036 motif II; other site 655816008037 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816008038 motif II; other site 655816008039 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 655816008040 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 655816008041 intersubunit interface [polypeptide binding]; other site 655816008042 active site 655816008043 Zn2+ binding site [ion binding]; other site 655816008044 L-ribulokinase; Region: L-ribulokinase; TIGR01234 655816008045 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 655816008046 putative N- and C-terminal domain interface [polypeptide binding]; other site 655816008047 putative active site [active] 655816008048 putative MgATP binding site [chemical binding]; other site 655816008049 catalytic site [active] 655816008050 metal binding site [ion binding]; metal-binding site 655816008051 carbohydrate binding site [chemical binding]; other site 655816008052 homodimer interface [polypeptide binding]; other site 655816008053 L-arabinose isomerase; Provisional; Region: PRK02929 655816008054 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 655816008055 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 655816008056 trimer interface [polypeptide binding]; other site 655816008057 putative substrate binding site [chemical binding]; other site 655816008058 putative metal binding site [ion binding]; other site 655816008059 Glycosyl hydrolase family 43; Region: GH43_ABN; cd08988 655816008060 substrate binding site [chemical binding]; other site 655816008061 active site 655816008062 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 655816008063 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 655816008064 oligomer interface [polypeptide binding]; other site 655816008065 active site 655816008066 metal binding site [ion binding]; metal-binding site 655816008067 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 655816008068 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 655816008069 23S rRNA binding site [nucleotide binding]; other site 655816008070 L21 binding site [polypeptide binding]; other site 655816008071 L13 binding site [polypeptide binding]; other site 655816008072 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 655816008073 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 655816008074 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 655816008075 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 655816008076 L20 leader; ribosomal protein operon infC-rpmI-rplT, untranslated leader autoregulatory structure; BSUW23_misc_RNA_47 655816008077 LrgB-like family; Region: LrgB; cl00596 655816008078 LrgA family; Region: LrgA; cl00608 655816008079 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 655816008080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816008081 active site 655816008082 phosphorylation site [posttranslational modification] 655816008083 intermolecular recognition site; other site 655816008084 dimerization interface [polypeptide binding]; other site 655816008085 LytTr DNA-binding domain; Region: LytTR; cl04498 655816008086 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 655816008087 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 655816008088 GAF domain; Region: GAF; cl15785 655816008089 Histidine kinase; Region: His_kinase; pfam06580 655816008090 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816008091 ATP binding site [chemical binding]; other site 655816008092 Mg2+ binding site [ion binding]; other site 655816008093 G-X-G motif; other site 655816008094 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 655816008095 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816008096 motif II; other site 655816008097 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 655816008098 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 655816008099 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 655816008100 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 655816008101 active site 655816008102 dimer interface [polypeptide binding]; other site 655816008103 motif 1; other site 655816008104 motif 2; other site 655816008105 motif 3; other site 655816008106 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 655816008107 anticodon binding site; other site 655816008108 YtxC-like family; Region: YtxC; cl08500 655816008109 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 655816008110 primosomal protein DnaI; Reviewed; Region: PRK08939 655816008111 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 655816008112 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816008113 Walker A motif; other site 655816008114 ATP binding site [chemical binding]; other site 655816008115 Walker B motif; other site 655816008116 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 655816008117 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 655816008118 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 655816008119 ATP cone domain; Region: ATP-cone; pfam03477 655816008120 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 655816008121 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 655816008122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816008123 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 655816008124 Helix-turn-helix domains; Region: HTH; cl00088 655816008125 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 655816008126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816008127 putative substrate translocation pore; other site 655816008128 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 655816008129 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 655816008130 active site 655816008131 catalytic tetrad [active] 655816008132 dephospho-CoA kinase; Region: TIGR00152 655816008133 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 655816008134 CoA-binding site [chemical binding]; other site 655816008135 ATP-binding [chemical binding]; other site 655816008136 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 655816008137 Domain of unknown function DUF; Region: DUF204; pfam02659 655816008138 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 655816008139 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 655816008140 DNA binding site [nucleotide binding] 655816008141 catalytic residue [active] 655816008142 H2TH interface [polypeptide binding]; other site 655816008143 putative catalytic residues [active] 655816008144 turnover-facilitating residue; other site 655816008145 intercalation triad [nucleotide binding]; other site 655816008146 8OG recognition residue [nucleotide binding]; other site 655816008147 putative reading head residues; other site 655816008148 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 655816008149 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 655816008150 DNA polymerase I; Provisional; Region: PRK05755 655816008151 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 655816008152 active site 655816008153 metal binding site 1 [ion binding]; metal-binding site 655816008154 putative 5' ssDNA interaction site; other site 655816008155 metal binding site 3; metal-binding site 655816008156 metal binding site 2 [ion binding]; metal-binding site 655816008157 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 655816008158 putative DNA binding site [nucleotide binding]; other site 655816008159 putative metal binding site [ion binding]; other site 655816008160 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 655816008161 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 655816008162 active site 655816008163 DNA binding site [nucleotide binding] 655816008164 catalytic site [active] 655816008165 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 655816008166 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 655816008167 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655816008168 dimer interface [polypeptide binding]; other site 655816008169 phosphorylation site [posttranslational modification] 655816008170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816008171 ATP binding site [chemical binding]; other site 655816008172 Mg2+ binding site [ion binding]; other site 655816008173 G-X-G motif; other site 655816008174 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 655816008175 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816008176 active site 655816008177 phosphorylation site [posttranslational modification] 655816008178 intermolecular recognition site; other site 655816008179 dimerization interface [polypeptide binding]; other site 655816008180 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655816008181 DNA binding site [nucleotide binding] 655816008182 malate dehydrogenase; Reviewed; Region: PRK06223 655816008183 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 655816008184 NAD(P) binding site [chemical binding]; other site 655816008185 dimer interface [polypeptide binding]; other site 655816008186 tetramer (dimer of dimers) interface [polypeptide binding]; other site 655816008187 substrate binding site [chemical binding]; other site 655816008188 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 655816008189 isocitrate dehydrogenase; Validated; Region: PRK07362 655816008190 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 655816008191 dimer interface [polypeptide binding]; other site 655816008192 Citrate synthase; Region: Citrate_synt; pfam00285 655816008193 active site 655816008194 citrylCoA binding site [chemical binding]; other site 655816008195 oxalacetate/citrate binding site [chemical binding]; other site 655816008196 coenzyme A binding site [chemical binding]; other site 655816008197 catalytic triad [active] 655816008198 Protein of unknown function (DUF441); Region: DUF441; cl01041 655816008199 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 655816008200 Domain of unknown function DUF20; Region: UPF0118; pfam01594 655816008201 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 655816008202 pyruvate kinase; Provisional; Region: PRK06354 655816008203 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 655816008204 domain interfaces; other site 655816008205 active site 655816008206 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 655816008207 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 655816008208 active site 655816008209 ADP/pyrophosphate binding site [chemical binding]; other site 655816008210 dimerization interface [polypeptide binding]; other site 655816008211 allosteric effector site; other site 655816008212 fructose-1,6-bisphosphate binding site; other site 655816008213 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 655816008214 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 655816008215 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 655816008216 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 655816008217 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 655816008218 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 655816008219 Malic enzyme, N-terminal domain; Region: malic; pfam00390 655816008220 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 655816008221 putative NAD(P) binding site [chemical binding]; other site 655816008222 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 655816008223 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 655816008224 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 655816008225 generic binding surface I; other site 655816008226 generic binding surface II; other site 655816008227 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 655816008228 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 655816008229 DHH family; Region: DHH; pfam01368 655816008230 DHHA1 domain; Region: DHHA1; pfam02272 655816008231 YtpI-like protein; Region: YtpI; pfam14007 655816008232 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 655816008233 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816008234 DNA-binding site [nucleotide binding]; DNA binding site 655816008235 DRTGG domain; Region: DRTGG; cl12147 655816008236 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 655816008237 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 655816008238 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 655816008239 active site 2 [active] 655816008240 active site 1 [active] 655816008241 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 655816008242 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 655816008243 classical (c) SDRs; Region: SDR_c; cd05233 655816008244 NAD(P) binding site [chemical binding]; other site 655816008245 active site 655816008246 argininosuccinate lyase; Provisional; Region: PRK00855 655816008247 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 655816008248 active sites [active] 655816008249 tetramer interface [polypeptide binding]; other site 655816008250 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 655816008251 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 655816008252 ANP binding site [chemical binding]; other site 655816008253 Substrate Binding Site II [chemical binding]; other site 655816008254 Substrate Binding Site I [chemical binding]; other site 655816008255 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 655816008256 MPT binding site; other site 655816008257 trimer interface [polypeptide binding]; other site 655816008258 Acetokinase family; Region: Acetate_kinase; cl01029 655816008259 propionate/acetate kinase; Provisional; Region: PRK12379 655816008260 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 655816008261 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816008262 S-adenosylmethionine binding site [chemical binding]; other site 655816008263 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 655816008264 dimer interface [polypeptide binding]; other site 655816008265 catalytic triad [active] 655816008266 peroxidatic and resolving cysteines [active] 655816008267 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 655816008268 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 655816008269 RDD family; Region: RDD; cl00746 655816008270 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 655816008271 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 655816008272 tandem repeat interface [polypeptide binding]; other site 655816008273 oligomer interface [polypeptide binding]; other site 655816008274 active site residues [active] 655816008275 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 655816008276 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 655816008277 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 655816008278 active site 655816008279 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 655816008280 AMP-binding enzyme; Region: AMP-binding; cl15778 655816008281 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 655816008282 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 655816008283 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 655816008284 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 655816008285 THUMP domain; Region: THUMP; cl12076 655816008286 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 655816008287 Ligand Binding Site [chemical binding]; other site 655816008288 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 655816008289 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 655816008290 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 655816008291 catalytic residue [active] 655816008292 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 655816008293 septation ring formation regulator EzrA; Provisional; Region: PRK04778 655816008294 histidinol-phosphatase; Reviewed; Region: PRK08123 655816008295 PHP-associated; Region: PHP_C; pfam13263 655816008296 Helix-turn-helix domains; Region: HTH; cl00088 655816008297 GAF domain; Region: GAF; cl15785 655816008298 GAF domain; Region: GAF; cl15785 655816008299 GAF domain; Region: GAF; cl15785 655816008300 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 655816008301 metal binding site [ion binding]; metal-binding site 655816008302 active site 655816008303 I-site; other site 655816008304 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 655816008305 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 655816008306 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 655816008307 RNA binding surface [nucleotide binding]; other site 655816008308 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 655816008309 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 655816008310 active site 655816008311 HIGH motif; other site 655816008312 dimer interface [polypeptide binding]; other site 655816008313 KMSKS motif; other site 655816008314 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 655816008315 RNA binding surface [nucleotide binding]; other site 655816008316 acetyl-CoA synthetase; Provisional; Region: PRK04319 655816008317 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 655816008318 AMP-binding enzyme; Region: AMP-binding; cl15778 655816008319 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 655816008320 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 655816008321 FOG: CBS domain [General function prediction only]; Region: COG0517 655816008322 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 655816008323 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 655816008324 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 655816008325 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 655816008326 flagellar motor protein MotS; Reviewed; Region: PRK06925 655816008327 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 655816008328 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 655816008329 ligand binding site [chemical binding]; other site 655816008330 flagellar motor protein MotP; Reviewed; Region: PRK06926 655816008331 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 655816008332 catabolite control protein A; Region: ccpA; TIGR01481 655816008333 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655816008334 DNA binding site [nucleotide binding] 655816008335 domain linker motif; other site 655816008336 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 655816008337 dimerization interface [polypeptide binding]; other site 655816008338 effector binding site; other site 655816008339 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 655816008340 Chorismate mutase type II; Region: CM_2; cl00693 655816008341 NeuB family; Region: NeuB; cl00496 655816008342 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 655816008343 YtxH-like protein; Region: YtxH; cl02079 655816008344 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 655816008345 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 655816008346 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 655816008347 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 655816008348 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 655816008349 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 655816008350 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816008351 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 655816008352 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 655816008353 putative tRNA-binding site [nucleotide binding]; other site 655816008354 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 655816008355 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 655816008356 catalytic residues [active] 655816008357 Protein of unknown function (DUF2872); Region: DUF2872; cl11924 655816008358 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 655816008359 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 655816008360 oligomer interface [polypeptide binding]; other site 655816008361 active site 655816008362 metal binding site [ion binding]; metal-binding site 655816008363 Predicted small secreted protein [Function unknown]; Region: COG5584 655816008364 malate dehydrogenase; Provisional; Region: PRK13529 655816008365 Malic enzyme, N-terminal domain; Region: malic; pfam00390 655816008366 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 655816008367 NAD(P) binding site [chemical binding]; other site 655816008368 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 655816008369 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816008370 S-adenosylmethionine binding site [chemical binding]; other site 655816008371 YtzH-like protein; Region: YtzH; pfam14165 655816008372 Phosphotransferase enzyme family; Region: APH; pfam01636 655816008373 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 655816008374 substrate binding site [chemical binding]; other site 655816008375 pullulanase, type I; Region: pulA_typeI; TIGR02104 655816008376 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 655816008377 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 655816008378 Ca binding site [ion binding]; other site 655816008379 active site 655816008380 catalytic site [active] 655816008381 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 655816008382 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 655816008383 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 655816008384 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 655816008385 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 655816008386 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 655816008387 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 655816008388 dimer interface [polypeptide binding]; other site 655816008389 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816008390 catalytic residue [active] 655816008391 dipeptidase PepV; Reviewed; Region: PRK07318 655816008392 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 655816008393 active site 655816008394 metal binding site [ion binding]; metal-binding site 655816008395 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 655816008396 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 655816008397 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 655816008398 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 655816008399 Walker A/P-loop; other site 655816008400 ATP binding site [chemical binding]; other site 655816008401 Q-loop/lid; other site 655816008402 ABC transporter signature motif; other site 655816008403 Walker B; other site 655816008404 D-loop; other site 655816008405 H-loop/switch region; other site 655816008406 Helix-turn-helix domains; Region: HTH; cl00088 655816008407 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 655816008408 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 655816008409 RNA binding surface [nucleotide binding]; other site 655816008410 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 655816008411 active site 655816008412 uracil binding [chemical binding]; other site 655816008413 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 655816008414 MatE; Region: MatE; cl10513 655816008415 MatE; Region: MatE; cl10513 655816008416 HI0933-like protein; Region: HI0933_like; pfam03486 655816008417 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816008418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816008419 BCCT family transporter; Region: BCCT; cl00569 655816008420 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 655816008421 Protein of unknown function, DUF624; Region: DUF624; cl02369 655816008422 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816008423 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 655816008424 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 655816008425 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 655816008426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 655816008427 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 655816008428 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655816008429 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 655816008430 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655816008431 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 655816008432 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 655816008433 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816008434 dimer interface [polypeptide binding]; other site 655816008435 conserved gate region; other site 655816008436 putative PBP binding loops; other site 655816008437 ABC-ATPase subunit interface; other site 655816008438 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816008439 NAD(P) binding site [chemical binding]; other site 655816008440 active site 655816008441 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 655816008442 biotin synthase; Validated; Region: PRK06256 655816008443 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655816008444 FeS/SAM binding site; other site 655816008445 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 655816008446 AAA domain; Region: AAA_26; pfam13500 655816008447 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 655816008448 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 655816008449 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 655816008450 substrate-cofactor binding pocket; other site 655816008451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816008452 catalytic residue [active] 655816008453 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 655816008454 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 655816008455 inhibitor-cofactor binding pocket; inhibition site 655816008456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816008457 catalytic residue [active] 655816008458 6-carboxyhexanoate--CoA ligase; Region: BioW; cl00625 655816008459 Pimeloyl-CoA synthetase [Coenzyme metabolism]; Region: BioW; COG1424 655816008460 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 655816008461 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 655816008462 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655816008463 DNA binding site [nucleotide binding] 655816008464 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 655816008465 putative ligand binding site [chemical binding]; other site 655816008466 putative dimerization interface [polypeptide binding]; other site 655816008467 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 655816008468 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 655816008469 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 655816008470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816008471 dimer interface [polypeptide binding]; other site 655816008472 conserved gate region; other site 655816008473 putative PBP binding loops; other site 655816008474 ABC-ATPase subunit interface; other site 655816008475 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 655816008476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816008477 dimer interface [polypeptide binding]; other site 655816008478 conserved gate region; other site 655816008479 putative PBP binding loops; other site 655816008480 ABC-ATPase subunit interface; other site 655816008481 alpha-galactosidase; Provisional; Region: PRK15076 655816008482 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 655816008483 NAD binding site [chemical binding]; other site 655816008484 sugar binding site [chemical binding]; other site 655816008485 divalent metal binding site [ion binding]; other site 655816008486 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 655816008487 dimer interface [polypeptide binding]; other site 655816008488 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 655816008489 active site residue [active] 655816008490 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 655816008491 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 655816008492 HIGH motif; other site 655816008493 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 655816008494 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 655816008495 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 655816008496 active site 655816008497 KMSKS motif; other site 655816008498 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 655816008499 tRNA binding surface [nucleotide binding]; other site 655816008500 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 655816008501 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 655816008502 PAS domain; Region: PAS_9; pfam13426 655816008503 putative active site [active] 655816008504 heme pocket [chemical binding]; other site 655816008505 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 655816008506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816008507 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816008508 putative substrate translocation pore; other site 655816008509 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 655816008510 MutS2 family protein; Region: mutS2; TIGR01069 655816008511 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 655816008512 FtsX-like permease family; Region: FtsX; cl15850 655816008513 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 655816008514 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 655816008515 Walker A/P-loop; other site 655816008516 ATP binding site [chemical binding]; other site 655816008517 Q-loop/lid; other site 655816008518 ABC transporter signature motif; other site 655816008519 Walker B; other site 655816008520 D-loop; other site 655816008521 H-loop/switch region; other site 655816008522 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 655816008523 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816008524 ATP binding site [chemical binding]; other site 655816008525 Mg2+ binding site [ion binding]; other site 655816008526 G-X-G motif; other site 655816008527 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 655816008528 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816008529 active site 655816008530 phosphorylation site [posttranslational modification] 655816008531 intermolecular recognition site; other site 655816008532 dimerization interface [polypeptide binding]; other site 655816008533 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655816008534 DNA binding site [nucleotide binding] 655816008535 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 655816008536 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 655816008537 FtsX-like permease family; Region: FtsX; cl15850 655816008538 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 655816008539 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 655816008540 Walker A/P-loop; other site 655816008541 ATP binding site [chemical binding]; other site 655816008542 Q-loop/lid; other site 655816008543 ABC transporter signature motif; other site 655816008544 Walker B; other site 655816008545 D-loop; other site 655816008546 H-loop/switch region; other site 655816008547 ABC-2 type transporter; Region: ABC2_membrane; cl11417 655816008548 ABC-2 type transporter; Region: ABC2_membrane; cl11417 655816008549 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 655816008550 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 655816008551 Walker A/P-loop; other site 655816008552 ATP binding site [chemical binding]; other site 655816008553 Q-loop/lid; other site 655816008554 ABC transporter signature motif; other site 655816008555 Walker B; other site 655816008556 D-loop; other site 655816008557 H-loop/switch region; other site 655816008558 Predicted transcriptional regulators [Transcription]; Region: COG1725 655816008559 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816008560 DNA-binding site [nucleotide binding]; DNA binding site 655816008561 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 655816008562 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 655816008563 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816008564 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816008565 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 655816008566 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 655816008567 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 655816008568 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 655816008569 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 655816008570 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 655816008571 trimer interface [polypeptide binding]; other site 655816008572 putative metal binding site [ion binding]; other site 655816008573 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 655816008574 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 655816008575 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 655816008576 active site 655816008577 dimer interface [polypeptide binding]; other site 655816008578 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 655816008579 Ligand Binding Site [chemical binding]; other site 655816008580 Molecular Tunnel; other site 655816008581 S-adenosylmethionine synthetase; Validated; Region: PRK05250 655816008582 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 655816008583 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 655816008584 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 655816008585 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 655816008586 active site 655816008587 substrate-binding site [chemical binding]; other site 655816008588 metal-binding site [ion binding] 655816008589 ATP binding site [chemical binding]; other site 655816008590 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 655816008591 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 655816008592 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 655816008593 NMT1-like family; Region: NMT1_2; cl15260 655816008594 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 655816008595 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 655816008596 Walker A/P-loop; other site 655816008597 ATP binding site [chemical binding]; other site 655816008598 Q-loop/lid; other site 655816008599 ABC transporter signature motif; other site 655816008600 Walker B; other site 655816008601 D-loop; other site 655816008602 H-loop/switch region; other site 655816008603 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 655816008604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816008605 dimer interface [polypeptide binding]; other site 655816008606 conserved gate region; other site 655816008607 putative PBP binding loops; other site 655816008608 ABC-ATPase subunit interface; other site 655816008609 Helix-turn-helix domains; Region: HTH; cl00088 655816008610 putative transposase OrfB; Reviewed; Region: PHA02517 655816008611 HTH-like domain; Region: HTH_21; pfam13276 655816008612 Integrase core domain; Region: rve; cl01316 655816008613 Integrase core domain; Region: rve_3; cl15866 655816008614 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 655816008615 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 655816008616 nudix motif; other site 655816008617 Holin family; Region: Phage_holin_4; cl01989 655816008618 Ferritin-like domain; Region: Ferritin; pfam00210 655816008619 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 655816008620 dimerization interface [polypeptide binding]; other site 655816008621 DPS ferroxidase diiron center [ion binding]; other site 655816008622 ion pore; other site 655816008623 FixH; Region: FixH; cl01254 655816008624 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 655816008625 Haemolytic domain; Region: Haemolytic; cl00506 655816008626 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 655816008627 active site clefts [active] 655816008628 zinc binding site [ion binding]; other site 655816008629 dimer interface [polypeptide binding]; other site 655816008630 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 655816008631 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 655816008632 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 655816008633 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 655816008634 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655816008635 ABC-ATPase subunit interface; other site 655816008636 dimer interface [polypeptide binding]; other site 655816008637 putative PBP binding regions; other site 655816008638 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655816008639 ABC-ATPase subunit interface; other site 655816008640 dimer interface [polypeptide binding]; other site 655816008641 putative PBP binding regions; other site 655816008642 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 655816008643 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 655816008644 Metal binding protein TroA. These proteins have been shown to function as initial receptors in ABC transport of Zn2+ and possibly Fe3+ in many eubacterial species. The TroA proteins belong to the TroA superfamily of periplasmic metal binding proteins...; Region: TroA; cd01016 655816008645 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 655816008646 metal binding site [ion binding]; metal-binding site 655816008647 intersubunit interface [polypeptide binding]; other site 655816008648 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 655816008649 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 655816008650 active site 655816008651 octamer interface [polypeptide binding]; other site 655816008652 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 655816008653 AMP-binding enzyme; Region: AMP-binding; cl15778 655816008654 AMP-binding enzyme; Region: AMP-binding; cl15778 655816008655 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 655816008656 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 655816008657 substrate binding site [chemical binding]; other site 655816008658 oxyanion hole (OAH) forming residues; other site 655816008659 trimer interface [polypeptide binding]; other site 655816008660 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 655816008661 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 655816008662 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 655816008663 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 655816008664 dimer interface [polypeptide binding]; other site 655816008665 tetramer interface [polypeptide binding]; other site 655816008666 PYR/PP interface [polypeptide binding]; other site 655816008667 TPP binding site [chemical binding]; other site 655816008668 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 655816008669 TPP-binding site; other site 655816008670 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 655816008671 chorismate binding enzyme; Region: Chorismate_bind; cl10555 655816008672 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 655816008673 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 655816008674 active site 655816008675 tetramer interface; other site 655816008676 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 655816008677 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816008678 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 655816008679 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816008680 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 655816008681 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816008682 NAD(P) binding site [chemical binding]; other site 655816008683 active site 655816008684 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 655816008685 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 655816008686 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 655816008687 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 655816008688 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 655816008689 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 655816008690 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 655816008691 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 655816008692 active site 655816008693 ATP binding site [chemical binding]; other site 655816008694 substrate binding site [chemical binding]; other site 655816008695 TspO/MBR family; Region: TspO_MBR; cl01379 655816008696 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 655816008697 homodimer interface [polypeptide binding]; other site 655816008698 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 655816008699 active site pocket [active] 655816008700 glycogen synthase; Provisional; Region: glgA; PRK00654 655816008701 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 655816008702 ADP-binding pocket [chemical binding]; other site 655816008703 homodimer interface [polypeptide binding]; other site 655816008704 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 655816008705 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 655816008706 ligand binding site; other site 655816008707 oligomer interface; other site 655816008708 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 655816008709 dimer interface [polypeptide binding]; other site 655816008710 N-terminal domain interface [polypeptide binding]; other site 655816008711 sulfate 1 binding site; other site 655816008712 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 655816008713 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 655816008714 ligand binding site; other site 655816008715 oligomer interface; other site 655816008716 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 655816008717 dimer interface [polypeptide binding]; other site 655816008718 N-terminal domain interface [polypeptide binding]; other site 655816008719 sulfate 1 binding site; other site 655816008720 alpha-1,4-glucan:alpha-1,4-glucan 6-glycosyltransferase; Region: branching_enzym; TIGR01515 655816008721 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 655816008722 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 655816008723 active site 655816008724 catalytic site [active] 655816008725 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 655816008726 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 655816008727 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 655816008728 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816008729 Coenzyme A binding pocket [chemical binding]; other site 655816008730 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 655816008731 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 655816008732 DinB superfamily; Region: DinB_2; pfam12867 655816008733 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 655816008734 MOSC domain; Region: MOSC; pfam03473 655816008735 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 655816008736 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 655816008737 active site 655816008738 NAD binding site [chemical binding]; other site 655816008739 metal binding site [ion binding]; metal-binding site 655816008740 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 655816008741 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 655816008742 tetramerization interface [polypeptide binding]; other site 655816008743 NAD(P) binding site [chemical binding]; other site 655816008744 catalytic residues [active] 655816008745 Predicted transcriptional regulators [Transcription]; Region: COG1510 655816008746 Helix-turn-helix domains; Region: HTH; cl00088 655816008747 ydaO riboswitch leader; regulates the expression of the potassium uptake operon through a riboswitch mechanism; ligand is unknown; BSUW23_misc_RNA_52 655816008748 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 655816008749 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816008750 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 655816008751 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 655816008752 Cation transport protein; Region: TrkH; cl10514 655816008753 yiaA/B two helix domain; Region: YiaAB; cl01759 655816008754 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 655816008755 SH3-like domain; Region: SH3_8; pfam13457 655816008756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816008757 putative substrate translocation pore; other site 655816008758 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816008759 Cysteine dioxygenase type I; Region: CDO_I; cl15835 655816008760 Bacitracin resistance protein BacA; Region: BacA; cl00858 655816008761 Domain of unknown function DUF20; Region: UPF0118; pfam01594 655816008762 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 655816008763 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 655816008764 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816008765 L-rhamnose isomerase; Provisional; Region: PRK01076 655816008766 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 655816008767 Domain of unknown function (DUF718); Region: DUF718; cl01281 655816008768 L-rhamnulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 655816008769 N- and C-terminal domain interface [polypeptide binding]; other site 655816008770 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 655816008771 active site 655816008772 catalytic site [active] 655816008773 metal binding site [ion binding]; metal-binding site 655816008774 ATP binding site [chemical binding]; other site 655816008775 carbohydrate binding site [chemical binding]; other site 655816008776 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 655816008777 Helix-turn-helix domains; Region: HTH; cl00088 655816008778 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 655816008779 short chain dehydrogenase; Validated; Region: PRK08324 655816008780 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 655816008781 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 655816008782 putative NAD(P) binding site [chemical binding]; other site 655816008783 active site 655816008784 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 655816008785 Cache domain; Region: Cache_1; pfam02743 655816008786 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 655816008787 dimerization interface [polypeptide binding]; other site 655816008788 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 655816008789 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 655816008790 dimer interface [polypeptide binding]; other site 655816008791 putative CheW interface [polypeptide binding]; other site 655816008792 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 655816008793 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 655816008794 Cache domain; Region: Cache_1; pfam02743 655816008795 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 655816008796 dimerization interface [polypeptide binding]; other site 655816008797 proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785 655816008798 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 655816008799 dimer interface [polypeptide binding]; other site 655816008800 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 655816008801 putative CheW interface [polypeptide binding]; other site 655816008802 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 655816008803 Cache domain; Region: Cache_1; pfam02743 655816008804 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 655816008805 dimerization interface [polypeptide binding]; other site 655816008806 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 655816008807 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 655816008808 dimer interface [polypeptide binding]; other site 655816008809 putative CheW interface [polypeptide binding]; other site 655816008810 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 655816008811 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 655816008812 Cache domain; Region: Cache_1; pfam02743 655816008813 two-component sensor protein; Provisional; Region: cpxA; PRK09470 655816008814 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 655816008815 dimerization interface [polypeptide binding]; other site 655816008816 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 655816008817 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 655816008818 dimer interface [polypeptide binding]; other site 655816008819 putative CheW interface [polypeptide binding]; other site 655816008820 transglutaminase; Provisional; Region: tgl; PRK03187 655816008821 Nitronate monooxygenase; Region: NMO; pfam03060 655816008822 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 655816008823 FMN binding site [chemical binding]; other site 655816008824 substrate binding site [chemical binding]; other site 655816008825 putative catalytic residue [active] 655816008826 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 655816008827 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 655816008828 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 655816008829 Ca binding site [ion binding]; other site 655816008830 active site 655816008831 catalytic site [active] 655816008832 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 655816008833 Helix-turn-helix domains; Region: HTH; cl00088 655816008834 putative transposase OrfB; Reviewed; Region: PHA02517 655816008835 HTH-like domain; Region: HTH_21; pfam13276 655816008836 Integrase core domain; Region: rve; cl01316 655816008837 Integrase core domain; Region: rve_3; cl15866 655816008838 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 655816008839 Domain of unknown function DUF21; Region: DUF21; pfam01595 655816008840 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 655816008841 Transporter associated domain; Region: CorC_HlyC; cl08393 655816008842 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 655816008843 Membrane-integrating protein Mistic; Region: Mistic; pfam11458 655816008844 Ion channel; Region: Ion_trans_2; cl11596 655816008845 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 655816008846 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816008847 YugN-like family; Region: YugN; pfam08868 655816008848 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 655816008849 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 655816008850 active site 655816008851 dimer interface [polypeptide binding]; other site 655816008852 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 655816008853 dimer interface [polypeptide binding]; other site 655816008854 active site 655816008855 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 655816008856 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 655816008857 dimer interface [polypeptide binding]; other site 655816008858 active site 655816008859 metal binding site [ion binding]; metal-binding site 655816008860 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 655816008861 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 655816008862 dimer interface [polypeptide binding]; other site 655816008863 active site 655816008864 metal binding site [ion binding]; metal-binding site 655816008865 Domain of unknown function (DUF378); Region: DUF378; cl00943 655816008866 general stress protein 13; Validated; Region: PRK08059 655816008867 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 655816008868 RNA binding site [nucleotide binding]; other site 655816008869 hypothetical protein; Validated; Region: PRK07682 655816008870 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655816008871 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816008872 homodimer interface [polypeptide binding]; other site 655816008873 catalytic residue [active] 655816008874 Helix-turn-helix domains; Region: HTH; cl00088 655816008875 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 655816008876 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 655816008877 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 655816008878 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 655816008879 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655816008880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816008881 homodimer interface [polypeptide binding]; other site 655816008882 catalytic residue [active] 655816008883 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655816008884 dimer interface [polypeptide binding]; other site 655816008885 phosphorylation site [posttranslational modification] 655816008886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816008887 ATP binding site [chemical binding]; other site 655816008888 Mg2+ binding site [ion binding]; other site 655816008889 G-X-G motif; other site 655816008890 Kinase associated protein B; Region: KapB; pfam08810 655816008891 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 655816008892 active site 655816008893 substrate binding site [chemical binding]; other site 655816008894 catalytic site [active] 655816008895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816008896 putative substrate translocation pore; other site 655816008897 Transglycosylase; Region: Transgly; cl07896 655816008898 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 655816008899 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 655816008900 Protein of unknown function, DUF393; Region: DUF393; cl01136 655816008901 Meckelin (Transmembrane protein 67); Region: Meckelin; pfam09773 655816008902 sensory histidine kinase DcuS; Provisional; Region: PRK11086 655816008903 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 655816008904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816008905 ATP binding site [chemical binding]; other site 655816008906 Mg2+ binding site [ion binding]; other site 655816008907 G-X-G motif; other site 655816008908 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 655816008909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816008910 active site 655816008911 phosphorylation site [posttranslational modification] 655816008912 intermolecular recognition site; other site 655816008913 dimerization interface [polypeptide binding]; other site 655816008914 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 655816008915 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 655816008916 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 655816008917 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 655816008918 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 655816008919 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 655816008920 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 655816008921 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 655816008922 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 655816008923 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 655816008924 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 655816008925 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 655816008926 CoenzymeA binding site [chemical binding]; other site 655816008927 subunit interaction site [polypeptide binding]; other site 655816008928 PHB binding site; other site 655816008929 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 655816008930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816008931 active site 655816008932 phosphorylation site [posttranslational modification] 655816008933 intermolecular recognition site; other site 655816008934 dimerization interface [polypeptide binding]; other site 655816008935 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655816008936 DNA binding residues [nucleotide binding] 655816008937 dimerization interface [polypeptide binding]; other site 655816008938 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 655816008939 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 655816008940 Histidine kinase; Region: HisKA_3; pfam07730 655816008941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816008942 ATP binding site [chemical binding]; other site 655816008943 Mg2+ binding site [ion binding]; other site 655816008944 G-X-G motif; other site 655816008945 Bacillus competence pheromone ComX; Region: ComX; pfam05952 655816008946 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 655816008947 substrate binding pocket [chemical binding]; other site 655816008948 substrate-Mg2+ binding site; other site 655816008949 aspartate-rich region 1; other site 655816008950 aspartate-rich region 2; other site 655816008951 DegQ (SacQ) family; Region: DegQ; pfam08181 655816008952 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 655816008953 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 655816008954 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 655816008955 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 655816008956 active site 655816008957 Isochorismatase family; Region: Isochorismatase; pfam00857 655816008958 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 655816008959 catalytic triad [active] 655816008960 conserved cis-peptide bond; other site 655816008961 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 655816008962 YueH-like protein; Region: YueH; pfam14166 655816008963 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 655816008964 Domain of unknown function DUF20; Region: UPF0118; pfam01594 655816008965 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 655816008966 Protein of unknown function (DUF2283); Region: DUF2283; cl02251 655816008967 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 655816008968 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 655816008969 short chain dehydrogenase; Provisional; Region: PRK06924 655816008970 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 655816008971 NADP binding site [chemical binding]; other site 655816008972 homodimer interface [polypeptide binding]; other site 655816008973 active site 655816008974 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 655816008975 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 655816008976 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 655816008977 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 655816008978 Predicted membrane protein [Function unknown]; Region: COG1511 655816008979 exosortase F-associated protein; Region: flavo_near_exo; TIGR04127 655816008980 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 655816008981 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 655816008982 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816008983 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816008984 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816008985 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816008986 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 655816008987 Ubiquitin-like proteins; Region: UBQ; cl00155 655816008988 Ubiquitin homologues; Region: UBQ; smart00213 655816008989 Proteins of 100 residues with WXG; Region: WXG100; cl02005 655816008990 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 655816008991 Helix-turn-helix domains; Region: HTH; cl00088 655816008992 alanine dehydrogenase; Region: alaDH; TIGR00518 655816008993 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 655816008994 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816008995 Uncharacterized conserved protein [Function unknown]; Region: COG5634 655816008996 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 655816008997 MbtH-like protein; Region: MbtH; cl01279 655816008998 peptide synthase; Provisional; Region: PRK12316 655816008999 AMP-binding enzyme; Region: AMP-binding; cl15778 655816009000 AMP-binding enzyme; Region: AMP-binding; cl15778 655816009001 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816009002 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 655816009003 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 655816009004 AMP-binding enzyme; Region: AMP-binding; cl15778 655816009005 AMP-binding enzyme; Region: AMP-binding; cl15778 655816009006 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816009007 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 655816009008 hydrophobic substrate binding pocket; other site 655816009009 Isochorismatase family; Region: Isochorismatase; pfam00857 655816009010 active site 655816009011 conserved cis-peptide bond; other site 655816009012 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816009013 2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275 655816009014 AMP-binding enzyme; Region: AMP-binding; cl15778 655816009015 AMP-binding enzyme; Region: AMP-binding; cl15778 655816009016 isochorismate synthase DhbC; Validated; Region: PRK06923 655816009017 chorismate binding enzyme; Region: Chorismate_bind; cl10555 655816009018 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 655816009019 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 655816009020 putative NAD(P) binding site [chemical binding]; other site 655816009021 active site 655816009022 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 655816009023 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 655816009024 Moco binding site; other site 655816009025 metal coordination site [ion binding]; other site 655816009026 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 655816009027 Predicted permease [General function prediction only]; Region: COG2056 655816009028 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 655816009029 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 655816009030 multifunctional aminopeptidase A; Provisional; Region: PRK00913 655816009031 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 655816009032 interface (dimer of trimers) [polypeptide binding]; other site 655816009033 Substrate-binding/catalytic site; other site 655816009034 Zn-binding sites [ion binding]; other site 655816009035 Divergent PAP2 family; Region: DUF212; cl00855 655816009036 3D domain; Region: 3D; cl01439 655816009037 Putative membrane protein; Region: YuiB; pfam14068 655816009038 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107 655816009039 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 655816009040 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655816009041 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 655816009042 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655816009043 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 655816009044 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 655816009045 active site 655816009046 Integral membrane protein DUF95; Region: DUF95; cl00572 655816009047 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 655816009048 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 655816009049 Walker A/P-loop; other site 655816009050 ATP binding site [chemical binding]; other site 655816009051 Q-loop/lid; other site 655816009052 ABC transporter signature motif; other site 655816009053 Walker B; other site 655816009054 D-loop; other site 655816009055 H-loop/switch region; other site 655816009056 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 655816009057 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 655816009058 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816009059 Coenzyme A binding pocket [chemical binding]; other site 655816009060 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 655816009061 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 655816009062 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 655816009063 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 655816009064 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 655816009065 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 655816009066 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 655816009067 Nucleoside recognition; Region: Gate; cl00486 655816009068 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 655816009069 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 655816009070 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 655816009071 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655816009072 Protein of unknown function (DUF1462); Region: DUF1462; cl11552 655816009073 NifU-like domain; Region: NifU; cl00484 655816009074 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 655816009075 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 655816009076 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 655816009077 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 655816009078 homoserine kinase; Region: thrB; TIGR00191 655816009079 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 655816009080 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 655816009081 threonine synthase; Reviewed; Region: PRK06721 655816009082 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 655816009083 homodimer interface [polypeptide binding]; other site 655816009084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816009085 catalytic residue [active] 655816009086 homoserine dehydrogenase; Provisional; Region: PRK06349 655816009087 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816009088 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 655816009089 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 655816009090 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 655816009091 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 655816009092 tetramer interfaces [polypeptide binding]; other site 655816009093 binuclear metal-binding site [ion binding]; other site 655816009094 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 655816009095 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816009096 active site 655816009097 motif I; other site 655816009098 motif II; other site 655816009099 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816009100 Protein of unknown function DUF86; Region: DUF86; cl01031 655816009101 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 655816009102 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 655816009103 lipoyl synthase; Provisional; Region: PRK05481 655816009104 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655816009105 FeS/SAM binding site; other site 655816009106 Peptidase family M23; Region: Peptidase_M23; pfam01551 655816009107 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 655816009108 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 655816009109 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 655816009110 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 655816009111 active site 655816009112 metal binding site [ion binding]; metal-binding site 655816009113 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 655816009114 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 655816009115 Protein of unknown function DUF72; Region: DUF72; cl00777 655816009116 allantoinase; Provisional; Region: PRK06189 655816009117 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 655816009118 active site 655816009119 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 655816009120 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 655816009121 Helix-turn-helix domains; Region: HTH; cl00088 655816009122 xanthine permease; Region: pbuX; TIGR03173 655816009123 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 655816009124 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 655816009125 xanthine permease; Region: pbuX; TIGR03173 655816009126 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 655816009127 Uricase (urate oxidase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3648 655816009128 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 655816009129 active site 655816009130 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 655816009131 active site 655816009132 homotetramer interface [polypeptide binding]; other site 655816009133 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 655816009134 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 655816009135 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 655816009136 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 655816009137 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 655816009138 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 655816009139 xanthine dehydrogenase C subunit; Region: pucC; TIGR03199 655816009140 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 655816009141 Ligand binding site; other site 655816009142 metal-binding site 655816009143 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 655816009144 XdhC Rossmann domain; Region: XdhC_C; pfam13478 655816009145 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 655816009146 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 655816009147 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 655816009148 catalytic residue [active] 655816009149 allantoate amidohydrolase; Reviewed; Region: PRK09290 655816009150 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 655816009151 active site 655816009152 metal binding site [ion binding]; metal-binding site 655816009153 dimer interface [polypeptide binding]; other site 655816009154 Endonuclease I; Region: Endonuclease_1; cl01003 655816009155 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 655816009156 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 655816009157 Walker A/P-loop; other site 655816009158 ATP binding site [chemical binding]; other site 655816009159 Q-loop/lid; other site 655816009160 ABC transporter signature motif; other site 655816009161 Walker B; other site 655816009162 D-loop; other site 655816009163 H-loop/switch region; other site 655816009164 TOBE domain; Region: TOBE_2; cl01440 655816009165 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816009166 DNA-binding site [nucleotide binding]; DNA binding site 655816009167 UTRA domain; Region: UTRA; cl01230 655816009168 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 655816009169 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 655816009170 substrate binding site [chemical binding]; other site 655816009171 ATP binding site [chemical binding]; other site 655816009172 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 655816009173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816009174 dimer interface [polypeptide binding]; other site 655816009175 conserved gate region; other site 655816009176 putative PBP binding loops; other site 655816009177 ABC-ATPase subunit interface; other site 655816009178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816009179 dimer interface [polypeptide binding]; other site 655816009180 conserved gate region; other site 655816009181 putative PBP binding loops; other site 655816009182 ABC-ATPase subunit interface; other site 655816009183 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 655816009184 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 655816009185 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 655816009186 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 655816009187 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 655816009188 putative active site [active] 655816009189 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 655816009190 dimer interface [polypeptide binding]; other site 655816009191 active site 655816009192 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 655816009193 GIY-YIG motif/motif A; other site 655816009194 active site 655816009195 catalytic site [active] 655816009196 putative DNA binding site [nucleotide binding]; other site 655816009197 metal binding site [ion binding]; metal-binding site 655816009198 FAD dependent oxidoreductase; Region: DAO; pfam01266 655816009199 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816009200 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 655816009201 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 655816009202 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 655816009203 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 655816009204 dimerization interface [polypeptide binding]; other site 655816009205 putative DNA binding site [nucleotide binding]; other site 655816009206 putative Zn2+ binding site [ion binding]; other site 655816009207 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 655816009208 FeS assembly protein SufB; Region: sufB; TIGR01980 655816009209 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 655816009210 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 655816009211 trimerization site [polypeptide binding]; other site 655816009212 active site 655816009213 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 655816009214 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 655816009215 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 655816009216 catalytic residue [active] 655816009217 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 655816009218 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 655816009219 FeS assembly ATPase SufC; Region: sufC; TIGR01978 655816009220 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 655816009221 Walker A/P-loop; other site 655816009222 ATP binding site [chemical binding]; other site 655816009223 Q-loop/lid; other site 655816009224 ABC transporter signature motif; other site 655816009225 Walker B; other site 655816009226 D-loop; other site 655816009227 H-loop/switch region; other site 655816009228 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 655816009229 NMT1-like family; Region: NMT1_2; cl15260 655816009230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816009231 conserved gate region; other site 655816009232 ABC-ATPase subunit interface; other site 655816009233 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 655816009234 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 655816009235 Walker A/P-loop; other site 655816009236 ATP binding site [chemical binding]; other site 655816009237 Q-loop/lid; other site 655816009238 ABC transporter signature motif; other site 655816009239 Walker B; other site 655816009240 D-loop; other site 655816009241 H-loop/switch region; other site 655816009242 NIL domain; Region: NIL; cl09633 655816009243 SCP-2 sterol transfer family; Region: SCP2; cl01225 655816009244 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 655816009245 catalytic residues [active] 655816009246 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 655816009247 putative active site [active] 655816009248 putative metal binding site [ion binding]; other site 655816009249 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 655816009250 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 655816009251 lipoyl attachment site [posttranslational modification]; other site 655816009252 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 655816009253 ArsC family; Region: ArsC; pfam03960 655816009254 putative ArsC-like catalytic residues; other site 655816009255 putative TRX-like catalytic residues [active] 655816009256 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 655816009257 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 655816009258 active site 655816009259 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 655816009260 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 655816009261 dimer interface [polypeptide binding]; other site 655816009262 active site 655816009263 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 655816009264 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816009265 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 655816009266 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 655816009267 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 655816009268 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 655816009269 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 655816009270 substrate binding site [chemical binding]; other site 655816009271 oxyanion hole (OAH) forming residues; other site 655816009272 trimer interface [polypeptide binding]; other site 655816009273 YuzL-like protein; Region: YuzL; pfam14115 655816009274 Proline dehydrogenase; Region: Pro_dh; cl03282 655816009275 Coat F domain; Region: Coat_F; cl15836 655816009276 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816009277 Helix-turn-helix domains; Region: HTH; cl00088 655816009278 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 655816009279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816009280 putative substrate translocation pore; other site 655816009281 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 655816009282 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 655816009283 classical (c) SDRs; Region: SDR_c; cd05233 655816009284 NAD(P) binding site [chemical binding]; other site 655816009285 active site 655816009286 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655816009287 Helix-turn-helix domains; Region: HTH; cl00088 655816009288 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 655816009289 putative dimerization interface [polypeptide binding]; other site 655816009290 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 655816009291 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 655816009292 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 655816009293 Walker A/P-loop; other site 655816009294 ATP binding site [chemical binding]; other site 655816009295 Q-loop/lid; other site 655816009296 ABC transporter signature motif; other site 655816009297 Walker B; other site 655816009298 D-loop; other site 655816009299 H-loop/switch region; other site 655816009300 YusW-like protein; Region: YusW; pfam14039 655816009301 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 655816009302 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 655816009303 active site 655816009304 Zn binding site [ion binding]; other site 655816009305 short chain dehydrogenase; Provisional; Region: PRK06914 655816009306 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 655816009307 NADP binding site [chemical binding]; other site 655816009308 active site 655816009309 steroid binding site; other site 655816009310 Ferritin-like domain; Region: Ferritin; pfam00210 655816009311 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 655816009312 dimerization interface [polypeptide binding]; other site 655816009313 DPS ferroxidase diiron center [ion binding]; other site 655816009314 ion pore; other site 655816009315 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 655816009316 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 655816009317 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 655816009318 protein binding site [polypeptide binding]; other site 655816009319 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 655816009320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816009321 active site 655816009322 phosphorylation site [posttranslational modification] 655816009323 intermolecular recognition site; other site 655816009324 dimerization interface [polypeptide binding]; other site 655816009325 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655816009326 DNA binding site [nucleotide binding] 655816009327 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 655816009328 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 655816009329 dimerization interface [polypeptide binding]; other site 655816009330 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655816009331 dimer interface [polypeptide binding]; other site 655816009332 phosphorylation site [posttranslational modification] 655816009333 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816009334 ATP binding site [chemical binding]; other site 655816009335 Mg2+ binding site [ion binding]; other site 655816009336 G-X-G motif; other site 655816009337 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655816009338 Helix-turn-helix domains; Region: HTH; cl00088 655816009339 fumarate hydratase; Reviewed; Region: fumC; PRK00485 655816009340 Class II fumarases; Region: Fumarase_classII; cd01362 655816009341 active site 655816009342 tetramer interface [polypeptide binding]; other site 655816009343 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 655816009344 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 655816009345 Spore germination protein; Region: Spore_permease; cl15802 655816009346 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 655816009347 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 655816009348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816009349 active site 655816009350 phosphorylation site [posttranslational modification] 655816009351 intermolecular recognition site; other site 655816009352 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655816009353 DNA binding residues [nucleotide binding] 655816009354 dimerization interface [polypeptide binding]; other site 655816009355 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 655816009356 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 655816009357 Histidine kinase; Region: HisKA_3; pfam07730 655816009358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816009359 ATP binding site [chemical binding]; other site 655816009360 Mg2+ binding site [ion binding]; other site 655816009361 G-X-G motif; other site 655816009362 Predicted membrane protein [Function unknown]; Region: COG4758 655816009363 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 655816009364 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 655816009365 Uncharacterized conserved protein [Function unknown]; Region: COG3595 655816009366 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 655816009367 PspA/IM30 family; Region: PspA_IM30; pfam04012 655816009368 H+ Antiporter protein; Region: 2A0121; TIGR00900 655816009369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816009370 putative substrate translocation pore; other site 655816009371 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 655816009372 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 655816009373 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 655816009374 Walker A/P-loop; other site 655816009375 ATP binding site [chemical binding]; other site 655816009376 Q-loop/lid; other site 655816009377 ABC transporter signature motif; other site 655816009378 Walker B; other site 655816009379 D-loop; other site 655816009380 H-loop/switch region; other site 655816009381 Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808 655816009382 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 655816009383 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655816009384 ABC-ATPase subunit interface; other site 655816009385 dimer interface [polypeptide binding]; other site 655816009386 putative PBP binding regions; other site 655816009387 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 655816009388 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 655816009389 putative binding site residues; other site 655816009390 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 655816009391 classical (c) SDRs; Region: SDR_c; cd05233 655816009392 NAD(P) binding site [chemical binding]; other site 655816009393 active site 655816009394 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 655816009395 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 655816009396 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655816009397 dimer interface [polypeptide binding]; other site 655816009398 phosphorylation site [posttranslational modification] 655816009399 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816009400 ATP binding site [chemical binding]; other site 655816009401 Mg2+ binding site [ion binding]; other site 655816009402 G-X-G motif; other site 655816009403 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 655816009404 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816009405 active site 655816009406 phosphorylation site [posttranslational modification] 655816009407 intermolecular recognition site; other site 655816009408 dimerization interface [polypeptide binding]; other site 655816009409 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655816009410 DNA binding site [nucleotide binding] 655816009411 hypothetical protein; Provisional; Region: PRK14082 655816009412 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 655816009413 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655816009414 DNA binding residues [nucleotide binding] 655816009415 YvrJ protein family; Region: YvrJ; pfam12841 655816009416 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 655816009417 Cupin domain; Region: Cupin_2; cl09118 655816009418 Cupin domain; Region: Cupin_2; cl09118 655816009419 Regulatory protein YrvL; Region: YrvL; pfam14184 655816009420 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 655816009421 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 655816009422 FtsX-like permease family; Region: FtsX; cl15850 655816009423 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 655816009424 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 655816009425 Walker A/P-loop; other site 655816009426 ATP binding site [chemical binding]; other site 655816009427 Q-loop/lid; other site 655816009428 ABC transporter signature motif; other site 655816009429 Walker B; other site 655816009430 D-loop; other site 655816009431 H-loop/switch region; other site 655816009432 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 655816009433 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 655816009434 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 655816009435 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 655816009436 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 655816009437 Walker A/P-loop; other site 655816009438 ATP binding site [chemical binding]; other site 655816009439 Q-loop/lid; other site 655816009440 ABC transporter signature motif; other site 655816009441 Walker B; other site 655816009442 D-loop; other site 655816009443 H-loop/switch region; other site 655816009444 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655816009445 ABC-ATPase subunit interface; other site 655816009446 dimer interface [polypeptide binding]; other site 655816009447 putative PBP binding regions; other site 655816009448 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655816009449 ABC-ATPase subunit interface; other site 655816009450 dimer interface [polypeptide binding]; other site 655816009451 putative PBP binding regions; other site 655816009452 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 655816009453 putative ligand binding residues [chemical binding]; other site 655816009454 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 655816009455 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 655816009456 Spore germination protein; Region: Spore_permease; cl15802 655816009457 Small spore protein J (Spore_SspJ); Region: Spore_SspJ; cl09798 655816009458 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 655816009459 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 655816009460 Sulfatase; Region: Sulfatase; cl10460 655816009461 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 655816009462 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 655816009463 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 655816009464 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 655816009465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816009466 dimer interface [polypeptide binding]; other site 655816009467 conserved gate region; other site 655816009468 putative PBP binding loops; other site 655816009469 ABC-ATPase subunit interface; other site 655816009470 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 655816009471 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 655816009472 active site 655816009473 catalytic tetrad [active] 655816009474 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 655816009475 sulfite reductase subunit beta; Provisional; Region: PRK13504 655816009476 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 655816009477 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 655816009478 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 655816009479 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 655816009480 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 655816009481 FAD binding pocket [chemical binding]; other site 655816009482 FAD binding motif [chemical binding]; other site 655816009483 catalytic residues [active] 655816009484 NAD binding pocket [chemical binding]; other site 655816009485 phosphate binding motif [ion binding]; other site 655816009486 beta-alpha-beta structure motif; other site 655816009487 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 655816009488 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816009489 Family description; Region: UvrD_C_2; cl15862 655816009490 UPF0126 domain; Region: UPF0126; pfam03458 655816009491 UPF0126 domain; Region: UPF0126; pfam03458 655816009492 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 655816009493 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 655816009494 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 655816009495 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 655816009496 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 655816009497 metal-binding site [ion binding] 655816009498 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 655816009499 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 655816009500 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 655816009501 metal-binding site [ion binding] 655816009502 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 655816009503 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 655816009504 metal-binding site [ion binding] 655816009505 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 655816009506 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 655816009507 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 655816009508 metal-binding site [ion binding] 655816009509 Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157 655816009510 putative homotetramer interface [polypeptide binding]; other site 655816009511 putative homodimer interface [polypeptide binding]; other site 655816009512 allosteric switch controlling residues; other site 655816009513 putative metal binding site [ion binding]; other site 655816009514 putative homodimer-homodimer interface [polypeptide binding]; other site 655816009515 putative oxidoreductase; Provisional; Region: PRK11579 655816009516 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816009517 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 655816009518 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 655816009519 Predicted membrane protein [Function unknown]; Region: COG1289 655816009520 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 655816009521 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 655816009522 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 655816009523 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816009524 DNA-binding site [nucleotide binding]; DNA binding site 655816009525 FCD domain; Region: FCD; cl11656 655816009526 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 655816009527 EamA-like transporter family; Region: EamA; cl01037 655816009528 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 655816009529 classical (c) SDRs; Region: SDR_c; cd05233 655816009530 NAD(P) binding site [chemical binding]; other site 655816009531 active site 655816009532 Rifampin ADP-ribosyl transferase; Region: Arr-ms; pfam12120 655816009533 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 655816009534 SmpB-tmRNA interface; other site 655816009535 ribonuclease R; Region: RNase_R; TIGR02063 655816009536 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 655816009537 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 655816009538 RNB domain; Region: RNB; pfam00773 655816009539 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 655816009540 RNA binding site [nucleotide binding]; other site 655816009541 Esterase/lipase [General function prediction only]; Region: COG1647 655816009542 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 655816009543 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 655816009544 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655816009545 salt bridge; other site 655816009546 non-specific DNA binding site [nucleotide binding]; other site 655816009547 sequence-specific DNA binding site [nucleotide binding]; other site 655816009548 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655816009549 non-specific DNA binding site [nucleotide binding]; other site 655816009550 salt bridge; other site 655816009551 sequence-specific DNA binding site [nucleotide binding]; other site 655816009552 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655816009553 non-specific DNA binding site [nucleotide binding]; other site 655816009554 salt bridge; other site 655816009555 sequence-specific DNA binding site [nucleotide binding]; other site 655816009556 Helix-turn-helix domains; Region: HTH; cl00088 655816009557 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655816009558 dimer interface [polypeptide binding]; other site 655816009559 phosphorylation site [posttranslational modification] 655816009560 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816009561 ATP binding site [chemical binding]; other site 655816009562 Mg2+ binding site [ion binding]; other site 655816009563 G-X-G motif; other site 655816009564 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 655816009565 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816009566 active site 655816009567 phosphorylation site [posttranslational modification] 655816009568 intermolecular recognition site; other site 655816009569 dimerization interface [polypeptide binding]; other site 655816009570 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655816009571 DNA binding site [nucleotide binding] 655816009572 ABC-2 type transporter; Region: ABC2_membrane; cl11417 655816009573 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 655816009574 ABC-2 type transporter; Region: ABC2_membrane; cl11417 655816009575 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 655816009576 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 655816009577 Walker A/P-loop; other site 655816009578 ATP binding site [chemical binding]; other site 655816009579 Q-loop/lid; other site 655816009580 ABC transporter signature motif; other site 655816009581 Walker B; other site 655816009582 D-loop; other site 655816009583 H-loop/switch region; other site 655816009584 Gallidermin; Region: Gallidermin; cl03420 655816009585 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 655816009586 LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793 655816009587 active site 655816009588 zinc binding site [ion binding]; other site 655816009589 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 655816009590 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 655816009591 Walker A/P-loop; other site 655816009592 ATP binding site [chemical binding]; other site 655816009593 Q-loop/lid; other site 655816009594 ABC transporter signature motif; other site 655816009595 Walker B; other site 655816009596 D-loop; other site 655816009597 H-loop/switch region; other site 655816009598 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 655816009599 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 655816009600 SpaB C-terminal domain; Region: SpaB_C; cl14828 655816009601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816009602 dimer interface [polypeptide binding]; other site 655816009603 conserved gate region; other site 655816009604 putative PBP binding loops; other site 655816009605 ABC-ATPase subunit interface; other site 655816009606 NMT1-like family; Region: NMT1_2; cl15260 655816009607 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 655816009608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816009609 dimer interface [polypeptide binding]; other site 655816009610 conserved gate region; other site 655816009611 putative PBP binding loops; other site 655816009612 ABC-ATPase subunit interface; other site 655816009613 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 655816009614 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 655816009615 Walker A/P-loop; other site 655816009616 ATP binding site [chemical binding]; other site 655816009617 Q-loop/lid; other site 655816009618 ABC transporter signature motif; other site 655816009619 Walker B; other site 655816009620 D-loop; other site 655816009621 H-loop/switch region; other site 655816009622 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 655816009623 Predicted transcriptional regulators [Transcription]; Region: COG1510 655816009624 Helix-turn-helix domains; Region: HTH; cl00088 655816009625 Dopey, N-terminal; Region: Dopey_N; cl04407 655816009626 Helix-turn-helix domains; Region: HTH; cl00088 655816009627 putative transposase OrfB; Reviewed; Region: PHA02517 655816009628 HTH-like domain; Region: HTH_21; pfam13276 655816009629 Integrase core domain; Region: rve; cl01316 655816009630 Integrase core domain; Region: rve_3; cl15866 655816009631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816009632 dimer interface [polypeptide binding]; other site 655816009633 conserved gate region; other site 655816009634 putative PBP binding loops; other site 655816009635 ABC-ATPase subunit interface; other site 655816009636 NMT1-like family; Region: NMT1_2; cl15260 655816009637 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 655816009638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816009639 dimer interface [polypeptide binding]; other site 655816009640 conserved gate region; other site 655816009641 putative PBP binding loops; other site 655816009642 ABC-ATPase subunit interface; other site 655816009643 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 655816009644 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 655816009645 Walker A/P-loop; other site 655816009646 ATP binding site [chemical binding]; other site 655816009647 Q-loop/lid; other site 655816009648 ABC transporter signature motif; other site 655816009649 Walker B; other site 655816009650 D-loop; other site 655816009651 H-loop/switch region; other site 655816009652 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 655816009653 Predicted transcriptional regulators [Transcription]; Region: COG1510 655816009654 Helix-turn-helix domains; Region: HTH; cl00088 655816009655 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 655816009656 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 655816009657 Predicted membrane protein [Function unknown]; Region: COG4640 655816009658 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 655816009659 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816009660 Coenzyme A binding pocket [chemical binding]; other site 655816009661 enolase; Provisional; Region: eno; PRK00077 655816009662 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 655816009663 dimer interface [polypeptide binding]; other site 655816009664 metal binding site [ion binding]; metal-binding site 655816009665 substrate binding pocket [chemical binding]; other site 655816009666 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 655816009667 Sulfatase; Region: Sulfatase; cl10460 655816009668 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 655816009669 substrate binding site [chemical binding]; other site 655816009670 dimer interface [polypeptide binding]; other site 655816009671 catalytic triad [active] 655816009672 Phosphoglycerate kinase; Region: PGK; pfam00162 655816009673 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 655816009674 substrate binding site [chemical binding]; other site 655816009675 hinge regions; other site 655816009676 ADP binding site [chemical binding]; other site 655816009677 catalytic site [active] 655816009678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816009679 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 655816009680 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 655816009681 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 655816009682 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 655816009683 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 655816009684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816009685 putative substrate translocation pore; other site 655816009686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816009687 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816009688 DNA-binding site [nucleotide binding]; DNA binding site 655816009689 Transcriptional regulators [Transcription]; Region: PurR; COG1609 655816009690 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 655816009691 putative dimerization interface [polypeptide binding]; other site 655816009692 putative ligand binding site [chemical binding]; other site 655816009693 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 655816009694 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 655816009695 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 655816009696 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 655816009697 active site 655816009698 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 655816009699 iron-sulfur cluster-binding protein; Region: TIGR00273 655816009700 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 655816009701 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 655816009702 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 655816009703 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 655816009704 Cysteine-rich domain; Region: CCG; pfam02754 655816009705 Cysteine-rich domain; Region: CCG; pfam02754 655816009706 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 655816009707 Helix-turn-helix domains; Region: HTH; cl00088 655816009708 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 655816009709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816009710 active site 655816009711 phosphorylation site [posttranslational modification] 655816009712 intermolecular recognition site; other site 655816009713 dimerization interface [polypeptide binding]; other site 655816009714 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655816009715 DNA binding residues [nucleotide binding] 655816009716 dimerization interface [polypeptide binding]; other site 655816009717 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 655816009718 Histidine kinase; Region: HisKA_3; pfam07730 655816009719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 655816009720 ABC-2 type transporter; Region: ABC2_membrane; cl11417 655816009721 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 655816009722 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 655816009723 Walker A/P-loop; other site 655816009724 ATP binding site [chemical binding]; other site 655816009725 Q-loop/lid; other site 655816009726 ABC transporter signature motif; other site 655816009727 Walker B; other site 655816009728 D-loop; other site 655816009729 H-loop/switch region; other site 655816009730 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 655816009731 PAS domain S-box; Region: sensory_box; TIGR00229 655816009732 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 655816009733 putative active site [active] 655816009734 heme pocket [chemical binding]; other site 655816009735 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 655816009736 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 655816009737 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 655816009738 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 655816009739 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 655816009740 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 655816009741 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 655816009742 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 655816009743 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 655816009744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816009745 dimer interface [polypeptide binding]; other site 655816009746 conserved gate region; other site 655816009747 putative PBP binding loops; other site 655816009748 ABC-ATPase subunit interface; other site 655816009749 TM2 domain; Region: TM2; cl00984 655816009750 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 655816009751 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816009752 dimer interface [polypeptide binding]; other site 655816009753 conserved gate region; other site 655816009754 ABC-ATPase subunit interface; other site 655816009755 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 655816009756 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 655816009757 Transcriptional regulators [Transcription]; Region: PurR; COG1609 655816009758 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655816009759 DNA binding site [nucleotide binding] 655816009760 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 655816009761 putative dimerization interface [polypeptide binding]; other site 655816009762 putative ligand binding site [chemical binding]; other site 655816009763 Transcriptional regulators [Transcription]; Region: FadR; COG2186 655816009764 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816009765 DNA-binding site [nucleotide binding]; DNA binding site 655816009766 FCD domain; Region: FCD; cl11656 655816009767 glycolate transporter; Provisional; Region: PRK09695 655816009768 L-lactate permease; Region: Lactate_perm; cl00701 655816009769 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 655816009770 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 655816009771 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 655816009772 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 655816009773 YvfG protein; Region: YvfG; pfam09628 655816009774 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 655816009775 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 655816009776 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 655816009777 inhibitor-cofactor binding pocket; inhibition site 655816009778 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816009779 catalytic residue [active] 655816009780 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 655816009781 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 655816009782 putative trimer interface [polypeptide binding]; other site 655816009783 putative CoA binding site [chemical binding]; other site 655816009784 Bacterial sugar transferase; Region: Bac_transf; cl00939 655816009785 MatE; Region: MatE; cl10513 655816009786 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 655816009787 active site 655816009788 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 655816009789 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 655816009790 active site 655816009791 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 655816009792 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 655816009793 putative ADP-binding pocket [chemical binding]; other site 655816009794 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 655816009795 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 655816009796 active site 655816009797 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 655816009798 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 655816009799 putative ADP-binding pocket [chemical binding]; other site 655816009800 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 655816009801 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816009802 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 655816009803 NAD(P) binding site [chemical binding]; other site 655816009804 homodimer interface [polypeptide binding]; other site 655816009805 substrate binding site [chemical binding]; other site 655816009806 active site 655816009807 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 655816009808 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816009809 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 655816009810 Chain length determinant protein; Region: Wzz; cl15801 655816009811 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655816009812 non-specific DNA binding site [nucleotide binding]; other site 655816009813 salt bridge; other site 655816009814 sequence-specific DNA binding site [nucleotide binding]; other site 655816009815 Anti-repressor SinI; Region: SinI; pfam08671 655816009816 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 655816009817 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 655816009818 substrate binding pocket [chemical binding]; other site 655816009819 catalytic triad [active] 655816009820 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 655816009821 Protein of unknown function (DUF3237); Region: DUF3237; cl07905 655816009822 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 655816009823 aspartate racemase; Region: asp_race; TIGR00035 655816009824 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 655816009825 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 655816009826 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 655816009827 active site 655816009828 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 655816009829 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 655816009830 substrate binding [chemical binding]; other site 655816009831 active site 655816009832 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 655816009833 amino acid transporter; Region: 2A0306; TIGR00909 655816009834 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655816009835 Helix-turn-helix domains; Region: HTH; cl00088 655816009836 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 655816009837 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 655816009838 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 655816009839 Clp protease; Region: CLP_protease; pfam00574 655816009840 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 655816009841 oligomer interface [polypeptide binding]; other site 655816009842 active site residues [active] 655816009843 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 655816009844 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 655816009845 Sulfate transporter family; Region: Sulfate_transp; cl15842 655816009846 putative transporter; Provisional; Region: PRK11660 655816009847 Sulfate transporter family; Region: Sulfate_transp; cl15842 655816009848 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 655816009849 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 655816009850 active site clefts [active] 655816009851 zinc binding site [ion binding]; other site 655816009852 dimer interface [polypeptide binding]; other site 655816009853 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 655816009854 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816009855 Predicted permease; Region: FtsX; cl11418 655816009856 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 655816009857 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 655816009858 Walker A/P-loop; other site 655816009859 ATP binding site [chemical binding]; other site 655816009860 Q-loop/lid; other site 655816009861 ABC transporter signature motif; other site 655816009862 Walker B; other site 655816009863 D-loop; other site 655816009864 H-loop/switch region; other site 655816009865 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 655816009866 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 655816009867 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816009868 ATP binding site [chemical binding]; other site 655816009869 Mg2+ binding site [ion binding]; other site 655816009870 G-X-G motif; other site 655816009871 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 655816009872 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816009873 active site 655816009874 phosphorylation site [posttranslational modification] 655816009875 intermolecular recognition site; other site 655816009876 dimerization interface [polypeptide binding]; other site 655816009877 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655816009878 DNA binding site [nucleotide binding] 655816009879 N-acetyltransferase; Region: Acetyltransf_2; cl00949 655816009880 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 655816009881 dimerization domain swap beta strand [polypeptide binding]; other site 655816009882 regulatory protein interface [polypeptide binding]; other site 655816009883 active site 655816009884 regulatory phosphorylation site [posttranslational modification]; other site 655816009885 conserved hypothetical protein; Region: MG103; TIGR00647 655816009886 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 655816009887 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 655816009888 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 655816009889 phosphate binding site [ion binding]; other site 655816009890 putative substrate binding pocket [chemical binding]; other site 655816009891 dimer interface [polypeptide binding]; other site 655816009892 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 655816009893 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 655816009894 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 655816009895 putative active site [active] 655816009896 nucleotide binding site [chemical binding]; other site 655816009897 nudix motif; other site 655816009898 putative metal binding site [ion binding]; other site 655816009899 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 655816009900 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816009901 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655816009902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 655816009903 NlpC/P60 family; Region: NLPC_P60; cl11438 655816009904 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816009905 binding surface 655816009906 TPR motif; other site 655816009907 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816009908 TPR motif; other site 655816009909 binding surface 655816009910 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 655816009911 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 655816009912 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816009913 Walker A/P-loop; other site 655816009914 ATP binding site [chemical binding]; other site 655816009915 Q-loop/lid; other site 655816009916 ABC transporter signature motif; other site 655816009917 Walker B; other site 655816009918 D-loop; other site 655816009919 H-loop/switch region; other site 655816009920 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 655816009921 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 655816009922 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 655816009923 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 655816009924 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 655816009925 substrate binding site [chemical binding]; other site 655816009926 glutamase interaction surface [polypeptide binding]; other site 655816009927 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 655816009928 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 655816009929 catalytic residues [active] 655816009930 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 655816009931 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 655816009932 putative active site [active] 655816009933 oxyanion strand; other site 655816009934 catalytic triad [active] 655816009935 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 655816009936 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 655816009937 putative active site pocket [active] 655816009938 4-fold oligomerization interface [polypeptide binding]; other site 655816009939 metal binding residues [ion binding]; metal-binding site 655816009940 3-fold/trimer interface [polypeptide binding]; other site 655816009941 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 655816009942 histidinol dehydrogenase; Region: hisD; TIGR00069 655816009943 NAD binding site [chemical binding]; other site 655816009944 dimerization interface [polypeptide binding]; other site 655816009945 product binding site; other site 655816009946 substrate binding site [chemical binding]; other site 655816009947 zinc binding site [ion binding]; other site 655816009948 catalytic residues [active] 655816009949 ATP phosphoribosyltransferase; Region: HisG; cl15266 655816009950 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 655816009951 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 655816009952 dimer interface [polypeptide binding]; other site 655816009953 motif 1; other site 655816009954 active site 655816009955 motif 2; other site 655816009956 motif 3; other site 655816009957 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 655816009958 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 655816009959 putative active site [active] 655816009960 Pectate lyase; Region: Pectate_lyase; pfam03211 655816009961 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 655816009962 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 655816009963 CoA binding site [chemical binding]; other site 655816009964 active site 655816009965 pyrophosphatase PpaX; Provisional; Region: PRK13288 655816009966 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816009967 motif II; other site 655816009968 Nucleoside recognition; Region: Gate; cl00486 655816009969 Nucleoside recognition; Region: Gate; cl00486 655816009970 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 655816009971 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 655816009972 DRTGG domain; Region: DRTGG; cl12147 655816009973 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 655816009974 Hpr binding site; other site 655816009975 active site 655816009976 homohexamer subunit interaction site [polypeptide binding]; other site 655816009977 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 655816009978 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 655816009979 active site 655816009980 dimer interface [polypeptide binding]; other site 655816009981 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 655816009982 active site 655816009983 trimer interface [polypeptide binding]; other site 655816009984 allosteric site; other site 655816009985 active site lid [active] 655816009986 hexamer (dimer of trimers) interface [polypeptide binding]; other site 655816009987 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 655816009988 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816009989 DNA-binding site [nucleotide binding]; DNA binding site 655816009990 UTRA domain; Region: UTRA; cl01230 655816009991 Lamin Tail Domain; Region: LTD; pfam00932 655816009992 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 655816009993 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 655816009994 putative active site [active] 655816009995 putative metal binding site [ion binding]; other site 655816009996 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816009997 Helix-turn-helix domains; Region: HTH; cl00088 655816009998 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 655816009999 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816010000 Helix-turn-helix domains; Region: HTH; cl00088 655816010001 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816010002 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816010003 putative substrate translocation pore; other site 655816010004 Membrane protein of unknown function; Region: DUF360; cl00850 655816010005 PspC domain; Region: PspC; cl00864 655816010006 Uncharacterized conserved protein [Function unknown]; Region: COG3595 655816010007 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 655816010008 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 655816010009 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 655816010010 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 655816010011 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 655816010012 excinuclease ABC subunit B; Provisional; Region: PRK05298 655816010013 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 655816010014 ATP binding site [chemical binding]; other site 655816010015 putative Mg++ binding site [ion binding]; other site 655816010016 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655816010017 nucleotide binding region [chemical binding]; other site 655816010018 ATP-binding site [chemical binding]; other site 655816010019 Ultra-violet resistance protein B; Region: UvrB; pfam12344 655816010020 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 655816010021 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 655816010022 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 655816010023 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 655816010024 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655816010025 Helix-turn-helix domains; Region: HTH; cl00088 655816010026 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816010027 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816010028 putative substrate translocation pore; other site 655816010029 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 655816010030 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 655816010031 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 655816010032 C-terminal peptidase (prc); Region: prc; TIGR00225 655816010033 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 655816010034 protein binding site [polypeptide binding]; other site 655816010035 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 655816010036 Catalytic dyad [active] 655816010037 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 655816010038 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 655816010039 FtsX-like permease family; Region: FtsX; cl15850 655816010040 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 655816010041 FtsE is a hydrophilic nucleotide-binding protein that binds FtsX to form a heterodimeric ATP-binding cassette (ABC)-type transporter that associates with the bacterial inner membrane. The FtsE/X transporter is thought to be involved in cell division and...; Region: ABC_FtsE_transporter; cd03292 655816010042 Walker A/P-loop; other site 655816010043 ATP binding site [chemical binding]; other site 655816010044 Q-loop/lid; other site 655816010045 ABC transporter signature motif; other site 655816010046 Walker B; other site 655816010047 D-loop; other site 655816010048 H-loop/switch region; other site 655816010049 Cytochrome c; Region: Cytochrom_C; cl11414 655816010050 Uncharacterized conserved protein [Function unknown]; Region: COG1284 655816010051 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 655816010052 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 655816010053 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 655816010054 peptide chain release factor 2; Provisional; Region: PRK06746 655816010055 RF-1 domain; Region: RF-1; cl02875 655816010056 RF-1 domain; Region: RF-1; cl02875 655816010057 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 655816010058 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816010059 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 655816010060 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816010061 SEC-C motif; Region: SEC-C; pfam02810 655816010062 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 655816010063 30S subunit binding site; other site 655816010064 Flagellar protein FliT; Region: FliT; cl05125 655816010065 Flagellar protein FliS; Region: FliS; cl00654 655816010066 flagellar capping protein; Validated; Region: fliD; PRK07737 655816010067 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 655816010068 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 655816010069 FlaG protein; Region: FlaG; cl00591 655816010070 flagellin; Provisional; Region: PRK12804 655816010071 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 655816010072 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 655816010073 Global regulator protein family; Region: CsrA; cl00670 655816010074 FliW protein; Region: FliW; cl00740 655816010075 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 655816010076 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 655816010077 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 655816010078 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 655816010079 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 655816010080 FlgN protein; Region: FlgN; cl09176 655816010081 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 655816010082 flagellar operon protein TIGR03826; Region: YvyF 655816010083 comF family protein; Region: comF; TIGR00201 655816010084 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 655816010085 active site 655816010086 Late competence development protein ComFB; Region: ComFB; pfam10719 655816010087 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 655816010088 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 655816010089 ATP binding site [chemical binding]; other site 655816010090 putative Mg++ binding site [ion binding]; other site 655816010091 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655816010092 nucleotide binding region [chemical binding]; other site 655816010093 ATP-binding site [chemical binding]; other site 655816010094 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 655816010095 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 655816010096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816010097 active site 655816010098 phosphorylation site [posttranslational modification] 655816010099 intermolecular recognition site; other site 655816010100 dimerization interface [polypeptide binding]; other site 655816010101 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655816010102 DNA binding residues [nucleotide binding] 655816010103 dimerization interface [polypeptide binding]; other site 655816010104 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 655816010105 Histidine kinase; Region: HisKA_3; pfam07730 655816010106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816010107 ATP binding site [chemical binding]; other site 655816010108 Mg2+ binding site [ion binding]; other site 655816010109 G-X-G motif; other site 655816010110 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 655816010111 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 655816010112 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 655816010113 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 655816010114 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 655816010115 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 655816010116 Mg++ binding site [ion binding]; other site 655816010117 putative catalytic motif [active] 655816010118 substrate binding site [chemical binding]; other site 655816010119 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 655816010120 putative homodimer interface [polypeptide binding]; other site 655816010121 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 655816010122 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 655816010123 active site 655816010124 Chain length determinant protein; Region: Wzz; cl15801 655816010125 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 655816010126 O-Antigen ligase; Region: Wzy_C; cl04850 655816010127 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 655816010128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816010129 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 655816010130 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816010131 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 655816010132 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 655816010133 colanic acid exporter; Provisional; Region: PRK10459 655816010134 MatE; Region: MatE; cl10513 655816010135 Bacterial sugar transferase; Region: Bac_transf; cl00939 655816010136 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 655816010137 active site 655816010138 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 655816010139 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 655816010140 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 655816010141 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 655816010142 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 655816010143 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 655816010144 active site 655816010145 metal binding site [ion binding]; metal-binding site 655816010146 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 655816010147 Putative cell wall-binding domain [Cell envelope biogenesis, outer membrane]; Region: LytB; COG2247 655816010148 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 655816010149 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 655816010150 Stage II sporulation protein; Region: SpoIID; pfam08486 655816010151 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 655816010152 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 655816010153 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 655816010154 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 655816010155 active site 655816010156 homodimer interface [polypeptide binding]; other site 655816010157 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 655816010158 active site 655816010159 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 655816010160 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 655816010161 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 655816010162 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 655816010163 active site 655816010164 tetramer interface; other site 655816010165 teichoic acids export protein ATP-binding subunit; Provisional; Region: tagH; PRK13545 655816010166 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 655816010167 Walker A/P-loop; other site 655816010168 ATP binding site [chemical binding]; other site 655816010169 Q-loop/lid; other site 655816010170 ABC transporter signature motif; other site 655816010171 Walker B; other site 655816010172 D-loop; other site 655816010173 H-loop/switch region; other site 655816010174 ABC-2 type transporter; Region: ABC2_membrane; cl11417 655816010175 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 655816010176 active site 655816010177 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 655816010178 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 655816010179 active site 655816010180 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 655816010181 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 655816010182 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 655816010183 active site 655816010184 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 655816010185 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 655816010186 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 655816010187 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 655816010188 substrate binding site; other site 655816010189 dimer interface; other site 655816010190 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 655816010191 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 655816010192 putative NAD(P) binding site [chemical binding]; other site 655816010193 putative catalytic Zn binding site [ion binding]; other site 655816010194 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 655816010195 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 655816010196 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 655816010197 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 655816010198 Bacterial SH3 domain; Region: SH3_3; cl02551 655816010199 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 655816010200 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 655816010201 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 655816010202 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 655816010203 Spore germination protein; Region: Spore_permease; cl15802 655816010204 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 655816010205 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 655816010206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816010207 putative substrate translocation pore; other site 655816010208 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 655816010209 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816010210 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 655816010211 active site 655816010212 motif I; other site 655816010213 motif II; other site 655816010214 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 655816010215 NlpC/P60 family; Region: NLPC_P60; cl11438 655816010216 NlpC/P60 family; Region: NLPC_P60; cl11438 655816010217 NlpC/P60 family; Region: NLPC_P60; cl11438 655816010218 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 655816010219 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 655816010220 putative active site [active] 655816010221 putative metal binding site [ion binding]; other site 655816010222 Capsule biosynthesis CapC; Region: Caps_synth_CapC; cl14855 655816010223 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 655816010224 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 655816010225 Transcriptional regulators [Transcription]; Region: PurR; COG1609 655816010226 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655816010227 DNA binding site [nucleotide binding] 655816010228 domain linker motif; other site 655816010229 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 655816010230 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 655816010231 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 655816010232 substrate binding site [chemical binding]; other site 655816010233 dimer interface [polypeptide binding]; other site 655816010234 ATP binding site [chemical binding]; other site 655816010235 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 655816010236 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 655816010237 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 655816010238 Walker A/P-loop; other site 655816010239 ATP binding site [chemical binding]; other site 655816010240 Q-loop/lid; other site 655816010241 ABC transporter signature motif; other site 655816010242 Walker B; other site 655816010243 D-loop; other site 655816010244 H-loop/switch region; other site 655816010245 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 655816010246 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 655816010247 TM-ABC transporter signature motif; other site 655816010248 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 655816010249 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 655816010250 ligand binding site [chemical binding]; other site 655816010251 dimerization interface [polypeptide binding]; other site 655816010252 Bacterial SH3 domain; Region: SH3_3; cl02551 655816010253 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 655816010254 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 655816010255 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 655816010256 acetolactate synthase; Reviewed; Region: PRK08617 655816010257 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 655816010258 PYR/PP interface [polypeptide binding]; other site 655816010259 dimer interface [polypeptide binding]; other site 655816010260 TPP binding site [chemical binding]; other site 655816010261 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 655816010262 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 655816010263 TPP-binding site [chemical binding]; other site 655816010264 dimer interface [polypeptide binding]; other site 655816010265 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 655816010266 Helix-turn-helix domains; Region: HTH; cl00088 655816010267 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 655816010268 putative dimerization interface [polypeptide binding]; other site 655816010269 putative substrate binding pocket [chemical binding]; other site 655816010270 Spore coat assembly protein [Cell envelope biogenesis, outer membrane]; Region: CotH; COG5337 655816010271 Flavin Reductases; Region: FlaRed; cl00801 655816010272 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 655816010273 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 655816010274 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 655816010275 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 655816010276 Helix-turn-helix domains; Region: HTH; cl00088 655816010277 Helix-turn-helix domains; Region: HTH; cl00088 655816010278 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 655816010279 Chromate transporter; Region: Chromate_transp; pfam02417 655816010280 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 655816010281 Chromate transporter; Region: Chromate_transp; pfam02417 655816010282 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 655816010283 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655816010284 Helix-turn-helix domains; Region: HTH; cl00088 655816010285 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 655816010286 dimerization interface [polypeptide binding]; other site 655816010287 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 655816010288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 655816010289 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 655816010290 Cupin domain; Region: Cupin_2; cl09118 655816010291 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 655816010292 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655816010293 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 655816010294 Active_site [active] 655816010295 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 655816010296 Uncharacterized conserved protein [Function unknown]; Region: COG5444 655816010297 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 655816010298 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 655816010299 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816010300 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 655816010301 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816010302 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 655816010303 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 655816010304 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816010305 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 655816010306 Chain length determinant protein; Region: Wzz; cl15801 655816010307 SWIM zinc finger; Region: SWIM; cl15408 655816010308 SNF2 Helicase protein; Region: DUF3670; pfam12419 655816010309 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 655816010310 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 655816010311 ATP binding site [chemical binding]; other site 655816010312 putative Mg++ binding site [ion binding]; other site 655816010313 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655816010314 nucleotide binding region [chemical binding]; other site 655816010315 ATP-binding site [chemical binding]; other site 655816010316 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816010317 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 655816010318 active site 655816010319 motif I; other site 655816010320 motif II; other site 655816010321 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 655816010322 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 655816010323 Helix-turn-helix domains; Region: HTH; cl00088 655816010324 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 655816010325 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 655816010326 dimer interface [polypeptide binding]; other site 655816010327 ssDNA binding site [nucleotide binding]; other site 655816010328 tetramer (dimer of dimers) interface [polypeptide binding]; other site 655816010329 YwpF-like protein; Region: YwpF; pfam14183 655816010330 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 655816010331 active site 655816010332 catalytic site [active] 655816010333 Collagen binding domain; Region: Collagen_bind; pfam05737 655816010334 Collagen binding domain; Region: Collagen_bind; pfam05737 655816010335 Collagen binding domain; Region: Collagen_bind; pfam05737 655816010336 Collagen binding domain; Region: Collagen_bind; pfam05737 655816010337 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 655816010338 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 655816010339 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 655816010340 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 655816010341 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 655816010342 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 655816010343 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 655816010344 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 655816010345 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 655816010346 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816010347 active site 655816010348 phosphorylation site [posttranslational modification] 655816010349 intermolecular recognition site; other site 655816010350 dimerization interface [polypeptide binding]; other site 655816010351 Helix-turn-helix domains; Region: HTH; cl00088 655816010352 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 655816010353 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 655816010354 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655816010355 dimer interface [polypeptide binding]; other site 655816010356 phosphorylation site [posttranslational modification] 655816010357 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816010358 ATP binding site [chemical binding]; other site 655816010359 Mg2+ binding site [ion binding]; other site 655816010360 G-X-G motif; other site 655816010361 Response regulator receiver domain; Region: Response_reg; pfam00072 655816010362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816010363 active site 655816010364 phosphorylation site [posttranslational modification] 655816010365 intermolecular recognition site; other site 655816010366 dimerization interface [polypeptide binding]; other site 655816010367 Histidine kinase; Region: His_kinase; pfam06580 655816010368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816010369 ATP binding site [chemical binding]; other site 655816010370 Mg2+ binding site [ion binding]; other site 655816010371 G-X-G motif; other site 655816010372 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 655816010373 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 655816010374 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 655816010375 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 655816010376 binding surface 655816010377 TPR motif; other site 655816010378 Tetratricopeptide repeat; Region: TPR_16; pfam13432 655816010379 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 655816010380 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 655816010381 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 655816010382 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 655816010383 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 655816010384 rod shape-determining protein Mbl; Provisional; Region: PRK13928 655816010385 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 655816010386 ATP binding site [chemical binding]; other site 655816010387 profilin binding site; other site 655816010388 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 655816010389 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816010390 Helix-turn-helix domains; Region: HTH; cl00088 655816010391 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816010392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816010393 putative substrate translocation pore; other site 655816010394 Right handed beta helix region; Region: Beta_helix; pfam13229 655816010395 Right handed beta helix region; Region: Beta_helix; pfam13229 655816010396 Sodium:solute symporter family; Region: SSF; cl00456 655816010397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816010398 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816010399 putative substrate translocation pore; other site 655816010400 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816010401 Isochorismatase family; Region: Isochorismatase; pfam00857 655816010402 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 655816010403 catalytic triad [active] 655816010404 conserved cis-peptide bond; other site 655816010405 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 655816010406 Nitrogen regulatory protein P-II; Region: P-II; cl00412 655816010407 Nitrogen regulatory protein P-II; Region: P-II; smart00938 655816010408 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 655816010409 active site 655816010410 VanZ like family; Region: VanZ; cl01971 655816010411 Peptidase family M23; Region: Peptidase_M23; pfam01551 655816010412 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 655816010413 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816010414 Coenzyme A binding pocket [chemical binding]; other site 655816010415 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 655816010416 NeuB family; Region: NeuB; cl00496 655816010417 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 655816010418 ligand binding site; other site 655816010419 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 655816010420 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 655816010421 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 655816010422 putative active site [active] 655816010423 catalytic site [active] 655816010424 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 655816010425 putative active site [active] 655816010426 catalytic site [active] 655816010427 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 655816010428 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 655816010429 DNA binding residues [nucleotide binding] 655816010430 dimer interface [polypeptide binding]; other site 655816010431 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 655816010432 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 655816010433 NADH(P)-binding; Region: NAD_binding_10; pfam13460 655816010434 NAD binding site [chemical binding]; other site 655816010435 substrate binding site [chemical binding]; other site 655816010436 putative active site [active] 655816010437 Predicted transcriptional regulator [Transcription]; Region: COG1959 655816010438 Helix-turn-helix domains; Region: HTH; cl00088 655816010439 urease subunit alpha; Reviewed; Region: ureC; PRK13207 655816010440 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 655816010441 subunit interactions [polypeptide binding]; other site 655816010442 active site 655816010443 flap region; other site 655816010444 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 655816010445 gamma-beta subunit interface [polypeptide binding]; other site 655816010446 alpha-beta subunit interface [polypeptide binding]; other site 655816010447 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 655816010448 alpha-gamma subunit interface [polypeptide binding]; other site 655816010449 beta-gamma subunit interface [polypeptide binding]; other site 655816010450 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 655816010451 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 655816010452 Walker A/P-loop; other site 655816010453 ATP binding site [chemical binding]; other site 655816010454 Q-loop/lid; other site 655816010455 ABC transporter signature motif; other site 655816010456 Walker B; other site 655816010457 D-loop; other site 655816010458 H-loop/switch region; other site 655816010459 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 655816010460 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 655816010461 Walker A/P-loop; other site 655816010462 ATP binding site [chemical binding]; other site 655816010463 Q-loop/lid; other site 655816010464 ABC transporter signature motif; other site 655816010465 Walker B; other site 655816010466 D-loop; other site 655816010467 H-loop/switch region; other site 655816010468 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 655816010469 TM-ABC transporter signature motif; other site 655816010470 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 655816010471 TM-ABC transporter signature motif; other site 655816010472 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 655816010473 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 655816010474 putative ligand binding site [chemical binding]; other site 655816010475 CsbD-like; Region: CsbD; cl15799 655816010476 Tetratricopeptide repeat; Region: TPR_12; pfam13424 655816010477 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 655816010478 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 655816010479 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655816010480 FeS/SAM binding site; other site 655816010481 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 655816010482 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 655816010483 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 655816010484 metal ion-dependent adhesion site (MIDAS); other site 655816010485 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ywmD_type; cd01456 655816010486 metal ion-dependent adhesion site (MIDAS); other site 655816010487 stage II sporulation protein D; Region: spore_II_D; TIGR02870 655816010488 Stage II sporulation protein; Region: SpoIID; pfam08486 655816010489 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 655816010490 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 655816010491 hinge; other site 655816010492 active site 655816010493 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 655816010494 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 655816010495 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 655816010496 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 655816010497 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 655816010498 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 655816010499 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 655816010500 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 655816010501 alpha subunit interaction interface [polypeptide binding]; other site 655816010502 Walker A motif; other site 655816010503 ATP binding site [chemical binding]; other site 655816010504 Walker B motif; other site 655816010505 inhibitor binding site; inhibition site 655816010506 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 655816010507 ATP synthase; Region: ATP-synt; cl00365 655816010508 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 655816010509 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 655816010510 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 655816010511 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 655816010512 beta subunit interaction interface [polypeptide binding]; other site 655816010513 Walker A motif; other site 655816010514 ATP binding site [chemical binding]; other site 655816010515 Walker B motif; other site 655816010516 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 655816010517 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 655816010518 Plant ATP synthase F0; Region: YMF19; cl07975 655816010519 Plant ATP synthase F0; Region: YMF19; cl07975 655816010520 ATP synthase subunit C; Region: ATP-synt_C; cl00466 655816010521 ATP synthase A chain; Region: ATP-synt_A; cl00413 655816010522 ATP synthase I chain; Region: ATP_synt_I; cl09170 655816010523 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 655816010524 active site 655816010525 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 655816010526 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 655816010527 dimer interface [polypeptide binding]; other site 655816010528 glycine-pyridoxal phosphate binding site [chemical binding]; other site 655816010529 active site 655816010530 folate binding site [chemical binding]; other site 655816010531 Protein of unknown function (DUF436); Region: DUF436; cl01860 655816010532 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 655816010533 Low molecular weight phosphatase family; Region: LMWPc; cd00115 655816010534 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 655816010535 active site 655816010536 Predicted membrane protein [Function unknown]; Region: COG1971 655816010537 Domain of unknown function DUF; Region: DUF204; pfam02659 655816010538 Domain of unknown function DUF; Region: DUF204; pfam02659 655816010539 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 655816010540 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 655816010541 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 655816010542 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775 655816010543 HemK family putative methylases; Region: hemK_fam; TIGR00536 655816010544 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816010545 S-adenosylmethionine binding site [chemical binding]; other site 655816010546 peptide chain release factor 1; Validated; Region: prfA; PRK00591 655816010547 RF-1 domain; Region: RF-1; cl02875 655816010548 RF-1 domain; Region: RF-1; cl02875 655816010549 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 655816010550 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 655816010551 putative metal binding site [ion binding]; other site 655816010552 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 655816010553 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 655816010554 DNA binding residues [nucleotide binding] 655816010555 Membrane transport protein; Region: Mem_trans; cl09117 655816010556 malate dehydrogenase; Provisional; Region: PRK13529 655816010557 Malic enzyme, N-terminal domain; Region: malic; pfam00390 655816010558 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 655816010559 NAD(P) binding site [chemical binding]; other site 655816010560 thymidine kinase; Provisional; Region: PRK04296 655816010561 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 655816010562 transcription termination factor Rho; Provisional; Region: rho; PRK09376 655816010563 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 655816010564 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 655816010565 RNA binding site [nucleotide binding]; other site 655816010566 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 655816010567 multimer interface [polypeptide binding]; other site 655816010568 Walker A motif; other site 655816010569 ATP binding site [chemical binding]; other site 655816010570 Walker B motif; other site 655816010571 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 655816010572 putative active site [active] 655816010573 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 655816010574 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 655816010575 hinge; other site 655816010576 active site 655816010577 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 655816010578 active site 655816010579 intersubunit interactions; other site 655816010580 catalytic residue [active] 655816010581 hypothetical protein; Provisional; Region: PRK08185 655816010582 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 655816010583 intersubunit interface [polypeptide binding]; other site 655816010584 active site 655816010585 zinc binding site [ion binding]; other site 655816010586 Na+ binding site [ion binding]; other site 655816010587 Response regulator receiver domain; Region: Response_reg; pfam00072 655816010588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816010589 active site 655816010590 phosphorylation site [posttranslational modification] 655816010591 intermolecular recognition site; other site 655816010592 dimerization interface [polypeptide binding]; other site 655816010593 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 655816010594 CTP synthetase; Validated; Region: pyrG; PRK05380 655816010595 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 655816010596 Catalytic site [active] 655816010597 active site 655816010598 UTP binding site [chemical binding]; other site 655816010599 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 655816010600 active site 655816010601 putative oxyanion hole; other site 655816010602 catalytic triad [active] 655816010603 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 655816010604 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 655816010605 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 655816010606 FAD binding site [chemical binding]; other site 655816010607 homotetramer interface [polypeptide binding]; other site 655816010608 substrate binding pocket [chemical binding]; other site 655816010609 catalytic base [active] 655816010610 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 655816010611 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 655816010612 Cysteine-rich domain; Region: CCG; pfam02754 655816010613 Cysteine-rich domain; Region: CCG; pfam02754 655816010614 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 655816010615 putative active site [active] 655816010616 catalytic site [active] 655816010617 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 655816010618 PLD-like domain; Region: PLDc_2; pfam13091 655816010619 putative active site [active] 655816010620 catalytic site [active] 655816010621 UV-endonuclease UvdE; Region: UvdE; cl10036 655816010622 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 655816010623 folate binding site [chemical binding]; other site 655816010624 NADP+ binding site [chemical binding]; other site 655816010625 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 655816010626 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 655816010627 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 655816010628 Walker A/P-loop; other site 655816010629 ATP binding site [chemical binding]; other site 655816010630 Q-loop/lid; other site 655816010631 ABC transporter signature motif; other site 655816010632 Walker B; other site 655816010633 D-loop; other site 655816010634 H-loop/switch region; other site 655816010635 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 655816010636 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 655816010637 putative active site [active] 655816010638 catalytic site [active] 655816010639 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 655816010640 putative active site [active] 655816010641 catalytic site [active] 655816010642 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 655816010643 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 655816010644 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 655816010645 nitrate reductase, beta subunit; Region: narH; TIGR01660 655816010646 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 655816010647 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 655816010648 [4Fe-4S] binding site [ion binding]; other site 655816010649 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 655816010650 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 655816010651 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 655816010652 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 655816010653 molybdopterin cofactor binding site; other site 655816010654 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 655816010655 ligand binding site [chemical binding]; other site 655816010656 flexible hinge region; other site 655816010657 YwiC-like protein; Region: YwiC; pfam14256 655816010658 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 655816010659 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 655816010660 ligand binding site [chemical binding]; other site 655816010661 flexible hinge region; other site 655816010662 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 655816010663 putative switch regulator; other site 655816010664 non-specific DNA interactions [nucleotide binding]; other site 655816010665 DNA binding site [nucleotide binding] 655816010666 sequence specific DNA binding site [nucleotide binding]; other site 655816010667 putative cAMP binding site [chemical binding]; other site 655816010668 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 655816010669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816010670 putative substrate translocation pore; other site 655816010671 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 655816010672 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 655816010673 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 655816010674 active site 655816010675 HIGH motif; other site 655816010676 KMSK motif region; other site 655816010677 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 655816010678 tRNA binding surface [nucleotide binding]; other site 655816010679 anticodon binding site; other site 655816010680 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 655816010681 Bacteriocin subtilosin A; Region: Subtilosin_A; pfam11420 655816010682 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 655816010683 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655816010684 FeS/SAM binding site; other site 655816010685 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 655816010686 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 655816010687 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 655816010688 Walker A/P-loop; other site 655816010689 ATP binding site [chemical binding]; other site 655816010690 Q-loop/lid; other site 655816010691 ABC transporter signature motif; other site 655816010692 Walker B; other site 655816010693 D-loop; other site 655816010694 H-loop/switch region; other site 655816010695 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 655816010696 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 655816010697 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 655816010698 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 655816010699 Uncharacterized conserved protein [Function unknown]; Region: COG3391 655816010700 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 655816010701 Tetratricopeptide repeat; Region: TPR_12; pfam13424 655816010702 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655816010703 TPR motif; other site 655816010704 binding surface 655816010705 Tetratricopeptide repeat; Region: TPR_12; pfam13424 655816010706 Rap-phr extracellular signalling; Region: PhrC_PhrF; pfam11131 655816010707 Arginase family; Region: Arginase; cl00306 655816010708 spermidine synthase; Provisional; Region: PRK00811 655816010709 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 655816010710 Transglycosylase; Region: Transgly; cl07896 655816010711 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 655816010712 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 655816010713 YwhD family; Region: YwhD; pfam08741 655816010714 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 655816010715 active site 655816010716 putative substrate binding region [chemical binding]; other site 655816010717 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 655816010718 active site 1 [active] 655816010719 dimer interface [polypeptide binding]; other site 655816010720 hexamer interface [polypeptide binding]; other site 655816010721 active site 2 [active] 655816010722 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816010723 Helix-turn-helix domains; Region: HTH; cl00088 655816010724 Helix-turn-helix domains; Region: HTH; cl00088 655816010725 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 655816010726 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 655816010727 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 655816010728 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 655816010729 active site 655816010730 dimer interface [polypeptide binding]; other site 655816010731 motif 1; other site 655816010732 motif 2; other site 655816010733 motif 3; other site 655816010734 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 655816010735 anticodon binding site; other site 655816010736 Uncharacterized conserved protein [Function unknown]; Region: COG3465 655816010737 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 655816010738 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 655816010739 Zn2+ binding site [ion binding]; other site 655816010740 Mg2+ binding site [ion binding]; other site 655816010741 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 655816010742 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 655816010743 rod shape-determining protein MreC; Provisional; Region: PRK13922 655816010744 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 655816010745 EamA-like transporter family; Region: EamA; cl01037 655816010746 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 655816010747 EamA-like transporter family; Region: EamA; cl01037 655816010748 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 655816010749 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 655816010750 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655816010751 Helix-turn-helix domains; Region: HTH; cl00088 655816010752 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 655816010753 putative dimerization interface [polypeptide binding]; other site 655816010754 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 655816010755 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 655816010756 Chlorite dismutase; Region: Chlor_dismutase; cl01280 655816010757 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 655816010758 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 655816010759 putative NAD(P) binding site [chemical binding]; other site 655816010760 putative active site [active] 655816010761 transaminase; Reviewed; Region: PRK08068 655816010762 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655816010763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816010764 homodimer interface [polypeptide binding]; other site 655816010765 catalytic residue [active] 655816010766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816010767 putative substrate translocation pore; other site 655816010768 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 655816010769 ATP-grasp domain; Region: ATP-grasp_4; cl03087 655816010770 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 655816010771 classical (c) SDRs; Region: SDR_c; cd05233 655816010772 NAD(P) binding site [chemical binding]; other site 655816010773 active site 655816010774 Cupin domain; Region: Cupin_2; cl09118 655816010775 Cupin domain; Region: Cupin_2; cl09118 655816010776 Prephenate dehydratase; Region: PDT; pfam00800 655816010777 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 655816010778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816010779 putative substrate translocation pore; other site 655816010780 S-methylmethionine transporter; Provisional; Region: PRK11387 655816010781 Spore germination protein; Region: Spore_permease; cl15802 655816010782 Arginine degradation protein (predicted deacylase) [Amino acid transport and metabolism]; Region: RocB; COG4187 655816010783 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 655816010784 putative metal binding site [ion binding]; other site 655816010785 putative dimer interface [polypeptide binding]; other site 655816010786 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 655816010787 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 655816010788 Glutamate binding site [chemical binding]; other site 655816010789 homodimer interface [polypeptide binding]; other site 655816010790 NAD binding site [chemical binding]; other site 655816010791 catalytic residues [active] 655816010792 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 655816010793 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 655816010794 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 655816010795 NAD(P) binding site [chemical binding]; other site 655816010796 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 655816010797 Cupin domain; Region: Cupin_2; cl09118 655816010798 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 655816010799 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 655816010800 NADP binding site [chemical binding]; other site 655816010801 active site 655816010802 putative substrate binding site [chemical binding]; other site 655816010803 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 655816010804 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 655816010805 NAD binding site [chemical binding]; other site 655816010806 substrate binding site [chemical binding]; other site 655816010807 homodimer interface [polypeptide binding]; other site 655816010808 active site 655816010809 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 655816010810 substrate binding site; other site 655816010811 tetramer interface; other site 655816010812 Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: spsG; COG3980 655816010813 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 655816010814 ligand binding site; other site 655816010815 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 655816010816 NeuB family; Region: NeuB; cl00496 655816010817 SAF domain; Region: SAF; cl00555 655816010818 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 655816010819 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 655816010820 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 655816010821 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 655816010822 inhibitor-cofactor binding pocket; inhibition site 655816010823 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816010824 catalytic residue [active] 655816010825 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 655816010826 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 655816010827 active site 655816010828 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; cl09881 655816010829 Protein of unknown function (DUF423); Region: DUF423; cl01008 655816010830 Permease family; Region: Xan_ur_permease; pfam00860 655816010831 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 655816010832 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 655816010833 NAD(P) binding site [chemical binding]; other site 655816010834 catalytic residues [active] 655816010835 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 655816010836 ligand binding site [chemical binding]; other site 655816010837 active site 655816010838 UGI interface [polypeptide binding]; other site 655816010839 catalytic site [active] 655816010840 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 655816010841 active site 655816010842 Ceramidase; Region: Ceramidase; pfam05875 655816010843 Helix-turn-helix domains; Region: HTH; cl00088 655816010844 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 655816010845 dimer interface [polypeptide binding]; other site 655816010846 substrate binding site [chemical binding]; other site 655816010847 ATP binding site [chemical binding]; other site 655816010848 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 655816010849 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 655816010850 substrate binding [chemical binding]; other site 655816010851 active site 655816010852 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 655816010853 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 655816010854 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 655816010855 active site turn [active] 655816010856 phosphorylation site [posttranslational modification] 655816010857 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 655816010858 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 655816010859 transcriptional antiterminator BglG; Provisional; Region: PRK09772 655816010860 CAT RNA binding domain; Region: CAT_RBD; cl03904 655816010861 PRD domain; Region: PRD; cl15445 655816010862 PRD domain; Region: PRD; cl15445 655816010863 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 655816010864 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 655816010865 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 655816010866 putative active site [active] 655816010867 catalytic triad [active] 655816010868 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 655816010869 PA/protease domain interface [polypeptide binding]; other site 655816010870 putative integrin binding motif; other site 655816010871 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 655816010872 FlgD Ig-like domain; Region: FlgD_ig; cl15790 655816010873 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 655816010874 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 655816010875 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 655816010876 dimer interface [polypeptide binding]; other site 655816010877 FMN binding site [chemical binding]; other site 655816010878 NADPH bind site [chemical binding]; other site 655816010879 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 655816010880 Sterol carrier protein domain; Region: SCP2_2; pfam13530 655816010881 Sterol carrier protein domain; Region: SCP2_2; pfam13530 655816010882 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 655816010883 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 655816010884 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 655816010885 Subunit I/III interface [polypeptide binding]; other site 655816010886 Subunit III/IV interface [polypeptide binding]; other site 655816010887 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 655816010888 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 655816010889 D-pathway; other site 655816010890 Putative ubiquinol binding site [chemical binding]; other site 655816010891 Low-spin heme (heme b) binding site [chemical binding]; other site 655816010892 Putative water exit pathway; other site 655816010893 Binuclear center (heme o3/CuB) [ion binding]; other site 655816010894 K-pathway; other site 655816010895 Putative proton exit pathway; other site 655816010896 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 655816010897 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 655816010898 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 655816010899 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 655816010900 galactose-1-phosphate uridylyltransferase, family 2; Region: galT_2; TIGR01239 655816010901 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 655816010902 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 655816010903 galactokinase; Provisional; Region: PRK05322 655816010904 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 655816010905 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 655816010906 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 655816010907 GtrA-like protein; Region: GtrA; cl00971 655816010908 Helix-turn-helix domains; Region: HTH; cl00088 655816010909 Anti-repressor SinI; Region: SinI; pfam08671 655816010910 Protein of unknown function, DUF485; Region: DUF485; cl01231 655816010911 Sodium:solute symporter family; Region: SSF; cl00456 655816010912 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 655816010913 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 655816010914 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 655816010915 catalytic residues [active] 655816010916 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 655816010917 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 655816010918 Imelysin; Region: Peptidase_M75; cl09159 655816010919 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 655816010920 thiamine phosphate binding site [chemical binding]; other site 655816010921 active site 655816010922 pyrophosphate binding site [ion binding]; other site 655816010923 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 655816010924 substrate binding site [chemical binding]; other site 655816010925 multimerization interface [polypeptide binding]; other site 655816010926 ATP binding site [chemical binding]; other site 655816010927 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655816010928 Helix-turn-helix domains; Region: HTH; cl00088 655816010929 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 655816010930 putative dimerization interface [polypeptide binding]; other site 655816010931 LrgA family; Region: LrgA; cl00608 655816010932 LrgB-like family; Region: LrgB; cl00596 655816010933 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816010934 Walker A/P-loop; other site 655816010935 ATP binding site [chemical binding]; other site 655816010936 ABC transporter; Region: ABC_tran; pfam00005 655816010937 Q-loop/lid; other site 655816010938 ABC transporter signature motif; other site 655816010939 Walker B; other site 655816010940 D-loop; other site 655816010941 H-loop/switch region; other site 655816010942 LrgB-like family; Region: LrgB; cl00596 655816010943 sugar efflux transporter; Region: 2A0120; TIGR00899 655816010944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816010945 putative substrate translocation pore; other site 655816010946 Uncharacterized conserved protein (DUF2196); Region: DUF2196; cl02044 655816010947 PUA domain; Region: PUA; cl00607 655816010948 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 655816010949 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 655816010950 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 655816010951 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 655816010952 active site 655816010953 metal binding site [ion binding]; metal-binding site 655816010954 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 655816010955 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 655816010956 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 655816010957 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 655816010958 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 655816010959 active site 655816010960 catalytic residues [active] 655816010961 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 655816010962 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 655816010963 active site turn [active] 655816010964 phosphorylation site [posttranslational modification] 655816010965 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 655816010966 transcriptional antiterminator BglG; Provisional; Region: PRK09772 655816010967 CAT RNA binding domain; Region: CAT_RBD; cl03904 655816010968 PRD domain; Region: PRD; cl15445 655816010969 PRD domain; Region: PRD; cl15445 655816010970 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 655816010971 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 655816010972 Ligand binding site; other site 655816010973 metal-binding site 655816010974 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; cl02331 655816010975 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816010976 Helix-turn-helix domains; Region: HTH; cl00088 655816010977 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 655816010978 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 655816010979 active site 655816010980 HIGH motif; other site 655816010981 dimer interface [polypeptide binding]; other site 655816010982 KMSKS motif; other site 655816010983 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 655816010984 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 655816010985 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 655816010986 PA/protease domain interface [polypeptide binding]; other site 655816010987 putative integrin binding motif; other site 655816010988 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 655816010989 metal binding site [ion binding]; metal-binding site 655816010990 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 655816010991 synthetase active site [active] 655816010992 NTP binding site [chemical binding]; other site 655816010993 metal binding site [ion binding]; metal-binding site 655816010994 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 655816010995 UbiA prenyltransferase family; Region: UbiA; cl00337 655816010996 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 655816010997 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 655816010998 AMP-binding enzyme; Region: AMP-binding; cl15778 655816010999 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 655816011000 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655816011001 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 655816011002 DltD N-terminal region; Region: DltD_N; pfam04915 655816011003 DltD central region; Region: DltD_M; pfam04918 655816011004 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 655816011005 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 655816011006 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 655816011007 putative NAD(P) binding site [chemical binding]; other site 655816011008 active site 655816011009 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 655816011010 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 655816011011 homodimer interface [polypeptide binding]; other site 655816011012 substrate-cofactor binding pocket; other site 655816011013 catalytic residue [active] 655816011014 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 655816011015 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 655816011016 NAD binding site [chemical binding]; other site 655816011017 sugar binding site [chemical binding]; other site 655816011018 divalent metal binding site [ion binding]; other site 655816011019 tetramer (dimer of dimers) interface [polypeptide binding]; other site 655816011020 dimer interface [polypeptide binding]; other site 655816011021 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 655816011022 methionine cluster; other site 655816011023 active site 655816011024 phosphorylation site [posttranslational modification] 655816011025 metal binding site [ion binding]; metal-binding site 655816011026 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 655816011027 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 655816011028 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 655816011029 active site 655816011030 P-loop; other site 655816011031 phosphorylation site [posttranslational modification] 655816011032 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 655816011033 Helix-turn-helix domains; Region: HTH; cl00088 655816011034 Helix-turn-helix domains; Region: HTH; cl00088 655816011035 PRD domain; Region: PRD; cl15445 655816011036 PRD domain; Region: PRD; cl15445 655816011037 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 655816011038 P-loop; other site 655816011039 active site 655816011040 phosphorylation site [posttranslational modification] 655816011041 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 655816011042 active site 655816011043 phosphorylation site [posttranslational modification] 655816011044 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 655816011045 active site 655816011046 DNA binding site [nucleotide binding] 655816011047 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 655816011048 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 655816011049 tetramer interface [polypeptide binding]; other site 655816011050 heme binding pocket [chemical binding]; other site 655816011051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816011052 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816011053 putative substrate translocation pore; other site 655816011054 ABC-2 type transporter; Region: ABC2_membrane; cl11417 655816011055 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 655816011056 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816011057 Walker A/P-loop; other site 655816011058 ATP binding site [chemical binding]; other site 655816011059 Q-loop/lid; other site 655816011060 ABC transporter signature motif; other site 655816011061 Walker B; other site 655816011062 D-loop; other site 655816011063 H-loop/switch region; other site 655816011064 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 655816011065 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 655816011066 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 655816011067 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655816011068 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655816011069 DNA binding residues [nucleotide binding] 655816011070 Sodium:solute symporter family; Region: SSF; cl00456 655816011071 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 655816011072 putative substrate binding site [chemical binding]; other site 655816011073 putative ATP binding site [chemical binding]; other site 655816011074 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 655816011075 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 655816011076 The CYD subfamily implicated in cytochrome bd biogenesis. The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd...; Region: ABCC_cytochrome_bd; cd03247 655816011077 Walker A/P-loop; other site 655816011078 ATP binding site [chemical binding]; other site 655816011079 Q-loop/lid; other site 655816011080 ABC transporter signature motif; other site 655816011081 Walker B; other site 655816011082 D-loop; other site 655816011083 H-loop/switch region; other site 655816011084 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 655816011085 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 655816011086 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816011087 ATP binding site [chemical binding]; other site 655816011088 Q-loop/lid; other site 655816011089 ABC transporter signature motif; other site 655816011090 Walker B; other site 655816011091 D-loop; other site 655816011092 H-loop/switch region; other site 655816011093 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 655816011094 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 655816011095 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 655816011096 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 655816011097 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 655816011098 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 655816011099 Peptidase family M48; Region: Peptidase_M48; cl12018 655816011100 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 655816011101 putative active site [active] 655816011102 putative metal binding site [ion binding]; other site 655816011103 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 655816011104 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 655816011105 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 655816011106 Walker A/P-loop; other site 655816011107 ATP binding site [chemical binding]; other site 655816011108 Q-loop/lid; other site 655816011109 ABC transporter signature motif; other site 655816011110 Walker B; other site 655816011111 D-loop; other site 655816011112 H-loop/switch region; other site 655816011113 TOBE domain; Region: TOBE_2; cl01440 655816011114 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 655816011115 Helix-turn-helix domains; Region: HTH; cl00088 655816011116 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 655816011117 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 655816011118 NAD(P) binding site [chemical binding]; other site 655816011119 catalytic residues [active] 655816011120 Uncharacterized conserved protein [Function unknown]; Region: COG1284 655816011121 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 655816011122 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 655816011123 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 655816011124 ykkC-yxkD riboswitch leader; may function to switch on expression of the ykkD efflux pump gene in response to toxic compounds; BSUW23_misc_RNA_60 655816011125 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 655816011126 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 655816011127 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 655816011128 UDP-glucose 4-epimerase; Region: PLN02240 655816011129 NAD binding site [chemical binding]; other site 655816011130 homodimer interface [polypeptide binding]; other site 655816011131 active site 655816011132 substrate binding site [chemical binding]; other site 655816011133 peptidase T; Region: peptidase-T; TIGR01882 655816011134 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 655816011135 metal binding site [ion binding]; metal-binding site 655816011136 dimer interface [polypeptide binding]; other site 655816011137 Scramblase; Region: Scramblase; cl02043 655816011138 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 655816011139 substrate binding site [chemical binding]; other site 655816011140 THF binding site; other site 655816011141 zinc-binding site [ion binding]; other site 655816011142 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 655816011143 substrate binding site [chemical binding]; other site 655816011144 THF binding site; other site 655816011145 zinc-binding site [ion binding]; other site 655816011146 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816011147 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 655816011148 NAD(P) binding site [chemical binding]; other site 655816011149 active site 655816011150 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 655816011151 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 655816011152 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 655816011153 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 655816011154 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 655816011155 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816011156 nucleoside transporter; Region: nupC; TIGR00804 655816011157 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 655816011158 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 655816011159 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 655816011160 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 655816011161 hydroperoxidase II; Provisional; Region: katE; PRK11249 655816011162 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 655816011163 tetramer interface [polypeptide binding]; other site 655816011164 heme binding pocket [chemical binding]; other site 655816011165 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 655816011166 domain interactions; other site 655816011167 Citrate transporter; Region: CitMHS; pfam03600 655816011168 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 655816011169 transmembrane helices; other site 655816011170 Protein of unknown function (DUF421); Region: DUF421; cl00990 655816011171 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 655816011172 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 655816011173 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 655816011174 active site turn [active] 655816011175 phosphorylation site [posttranslational modification] 655816011176 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 655816011177 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 655816011178 HPr interaction site; other site 655816011179 glycerol kinase (GK) interaction site [polypeptide binding]; other site 655816011180 active site 655816011181 phosphorylation site [posttranslational modification] 655816011182 transcriptional antiterminator BglG; Provisional; Region: PRK09772 655816011183 CAT RNA binding domain; Region: CAT_RBD; cl03904 655816011184 PRD domain; Region: PRD; cl15445 655816011185 PRD domain; Region: PRD; cl15445 655816011186 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 655816011187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816011188 putative substrate translocation pore; other site 655816011189 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 655816011190 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 655816011191 ATP binding site [chemical binding]; other site 655816011192 Mg++ binding site [ion binding]; other site 655816011193 motif III; other site 655816011194 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655816011195 nucleotide binding region [chemical binding]; other site 655816011196 ATP-binding site [chemical binding]; other site 655816011197 DbpA RNA binding domain; Region: DbpA; pfam03880 655816011198 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 655816011199 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 655816011200 active site 655816011201 catalytic triad [active] 655816011202 Helix-turn-helix domains; Region: HTH; cl00088 655816011203 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 655816011204 YxiJ-like protein; Region: YxiJ; pfam14176 655816011205 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 655816011206 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 655816011207 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 655816011208 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 655816011209 RHS Repeat; Region: RHS_repeat; cl11982 655816011210 RHS Repeat; Region: RHS_repeat; cl11982 655816011211 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 655816011212 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 655816011213 RHS Repeat; Region: RHS_repeat; cl11982 655816011214 RHS Repeat; Region: RHS_repeat; cl11982 655816011215 RHS Repeat; Region: RHS_repeat; cl11982 655816011216 RHS Repeat; Region: RHS_repeat; cl11982 655816011217 RHS Repeat; Region: RHS_repeat; cl11982 655816011218 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 655816011219 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816011220 EamA-like transporter family; Region: EamA; cl01037 655816011221 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 655816011222 EamA-like transporter family; Region: EamA; cl01037 655816011223 Integral membrane protein TerC family; Region: TerC; cl10468 655816011224 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 655816011225 Ligand Binding Site [chemical binding]; other site 655816011226 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 655816011227 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 655816011228 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 655816011229 active site turn [active] 655816011230 phosphorylation site [posttranslational modification] 655816011231 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 655816011232 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 655816011233 HPr interaction site; other site 655816011234 glycerol kinase (GK) interaction site [polypeptide binding]; other site 655816011235 active site 655816011236 phosphorylation site [posttranslational modification] 655816011237 Uncharacterized conserved protein [Function unknown]; Region: COG5444 655816011238 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 655816011239 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 655816011240 substrate binding site [chemical binding]; other site 655816011241 active site 655816011242 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 655816011243 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816011244 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 655816011245 HutP; Region: HutP; cl07944 655816011246 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 655816011247 active sites [active] 655816011248 tetramer interface [polypeptide binding]; other site 655816011249 urocanate hydratase; Provisional; Region: PRK05414 655816011250 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816011251 imidazolonepropionase; Validated; Region: PRK09356 655816011252 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 655816011253 active site 655816011254 Arginase family; Region: Arginase; cl00306 655816011255 S-methylmethionine transporter; Provisional; Region: PRK11387 655816011256 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 655816011257 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 655816011258 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 655816011259 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 655816011260 nucleoside transporter; Region: nupC; TIGR00804 655816011261 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 655816011262 Nucleoside recognition; Region: Gate; cl00486 655816011263 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 655816011264 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 655816011265 intersubunit interface [polypeptide binding]; other site 655816011266 active site 655816011267 catalytic residue [active] 655816011268 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 655816011269 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 655816011270 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 655816011271 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 655816011272 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 655816011273 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 655816011274 Ethanolamine utilisation protein, EutH; Region: EutH; cl01248 655816011275 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 655816011276 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 655816011277 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 655816011278 metal binding site [ion binding]; metal-binding site 655816011279 dimer interface [polypeptide binding]; other site 655816011280 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 655816011281 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 655816011282 Walker A/P-loop; other site 655816011283 ATP binding site [chemical binding]; other site 655816011284 Q-loop/lid; other site 655816011285 ABC transporter signature motif; other site 655816011286 Walker B; other site 655816011287 D-loop; other site 655816011288 H-loop/switch region; other site 655816011289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655816011290 dimer interface [polypeptide binding]; other site 655816011291 conserved gate region; other site 655816011292 putative PBP binding loops; other site 655816011293 ABC-ATPase subunit interface; other site 655816011294 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 655816011295 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 655816011296 substrate binding pocket [chemical binding]; other site 655816011297 membrane-bound complex binding site; other site 655816011298 hinge residues; other site 655816011299 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 655816011300 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816011301 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 655816011302 Coenzyme A binding pocket [chemical binding]; other site 655816011303 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 655816011304 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 655816011305 active site 655816011306 non-prolyl cis peptide bond; other site 655816011307 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 655816011308 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 655816011309 active site 655816011310 sugar phosphate phosphatase; Provisional; Region: PRK10513 655816011311 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816011312 active site 655816011313 motif I; other site 655816011314 motif II; other site 655816011315 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655816011316 Protein of unknown function (DUF3255); Region: DUF3255; pfam11631 655816011317 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 655816011318 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 655816011319 putative ligand binding residues [chemical binding]; other site 655816011320 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 655816011321 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 655816011322 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 655816011323 Walker A/P-loop; other site 655816011324 ATP binding site [chemical binding]; other site 655816011325 Q-loop/lid; other site 655816011326 ABC transporter signature motif; other site 655816011327 Walker B; other site 655816011328 D-loop; other site 655816011329 H-loop/switch region; other site 655816011330 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 655816011331 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816011332 ATP binding site [chemical binding]; other site 655816011333 Mg2+ binding site [ion binding]; other site 655816011334 G-X-G motif; other site 655816011335 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 655816011336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816011337 active site 655816011338 phosphorylation site [posttranslational modification] 655816011339 intermolecular recognition site; other site 655816011340 dimerization interface [polypeptide binding]; other site 655816011341 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655816011342 DNA binding site [nucleotide binding] 655816011343 hypothetical protein; Provisional; Region: PRK08185 655816011344 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 655816011345 intersubunit interface [polypeptide binding]; other site 655816011346 active site 655816011347 zinc binding site [ion binding]; other site 655816011348 Na+ binding site [ion binding]; other site 655816011349 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 655816011350 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 655816011351 Metal-binding active site; metal-binding site 655816011352 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 655816011353 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 655816011354 DNA interaction; other site 655816011355 Metal-binding active site; metal-binding site 655816011356 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 655816011357 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816011358 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 655816011359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816011360 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655816011361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816011362 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 655816011363 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 655816011364 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 655816011365 PYR/PP interface [polypeptide binding]; other site 655816011366 dimer interface [polypeptide binding]; other site 655816011367 TPP binding site [chemical binding]; other site 655816011368 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 655816011369 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 655816011370 TPP-binding site; other site 655816011371 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 655816011372 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 655816011373 substrate binding site [chemical binding]; other site 655816011374 ATP binding site [chemical binding]; other site 655816011375 KduI/IolB family; Region: KduI; cl01508 655816011376 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 655816011377 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 655816011378 tetrameric interface [polypeptide binding]; other site 655816011379 NAD binding site [chemical binding]; other site 655816011380 catalytic residues [active] 655816011381 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 655816011382 Helix-turn-helix domains; Region: HTH; cl00088 655816011383 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 655816011384 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 655816011385 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 655816011386 active site 655816011387 catalytic tetrad [active] 655816011388 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 655816011389 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 655816011390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816011391 putative substrate translocation pore; other site 655816011392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816011393 heat shock protein 90; Provisional; Region: PRK05218 655816011394 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 655816011395 short chain dehydrogenase; Validated; Region: PRK08589 655816011396 classical (c) SDRs; Region: SDR_c; cd05233 655816011397 NAD(P) binding site [chemical binding]; other site 655816011398 active site 655816011399 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655816011400 Helix-turn-helix domains; Region: HTH; cl00088 655816011401 Helix-turn-helix domains; Region: HTH; cl00088 655816011402 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 655816011403 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 655816011404 NAD(P) binding site [chemical binding]; other site 655816011405 catalytic residues [active] 655816011406 RDD family; Region: RDD; cl00746 655816011407 Predicted membrane protein [Function unknown]; Region: COG2311 655816011408 Protein of unknown function (DUF418); Region: DUF418; cl12135 655816011409 Cupin domain; Region: Cupin_2; cl09118 655816011410 Cupin domain; Region: Cupin_2; cl09118 655816011411 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655816011412 Helix-turn-helix domains; Region: HTH; cl00088 655816011413 short chain dehydrogenase; Provisional; Region: PRK07109 655816011414 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 655816011415 putative NAD(P) binding site [chemical binding]; other site 655816011416 active site 655816011417 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816011418 Helix-turn-helix domains; Region: HTH; cl00088 655816011419 LrgA family; Region: LrgA; cl00608 655816011420 LrgB-like family; Region: LrgB; cl00596 655816011421 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 655816011422 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 655816011423 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 655816011424 Glycerate kinase family; Region: Gly_kinase; cl00841 655816011425 Transcriptional regulators [Transcription]; Region: GntR; COG1802 655816011426 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816011427 DNA-binding site [nucleotide binding]; DNA binding site 655816011428 FCD domain; Region: FCD; cl11656 655816011429 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 655816011430 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 655816011431 N- and C-terminal domain interface [polypeptide binding]; other site 655816011432 putative active site [active] 655816011433 catalytic site [active] 655816011434 metal binding site [ion binding]; metal-binding site 655816011435 carbohydrate binding site [chemical binding]; other site 655816011436 ATP binding site [chemical binding]; other site 655816011437 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 655816011438 gluconate transporter; Region: gntP; TIGR00791 655816011439 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816011440 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 655816011441 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 655816011442 peroxiredoxin; Region: AhpC; TIGR03137 655816011443 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 655816011444 dimer interface [polypeptide binding]; other site 655816011445 decamer (pentamer of dimers) interface [polypeptide binding]; other site 655816011446 catalytic triad [active] 655816011447 peroxidatic and resolving cysteines [active] 655816011448 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 655816011449 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 655816011450 catalytic residue [active] 655816011451 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 655816011452 catalytic residues [active] 655816011453 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655816011454 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 655816011455 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 655816011456 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 655816011457 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 655816011458 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 655816011459 active site turn [active] 655816011460 phosphorylation site [posttranslational modification] 655816011461 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 655816011462 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 655816011463 HPr interaction site; other site 655816011464 glycerol kinase (GK) interaction site [polypeptide binding]; other site 655816011465 active site 655816011466 phosphorylation site [posttranslational modification] 655816011467 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 655816011468 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655816011469 DNA-binding site [nucleotide binding]; DNA binding site 655816011470 UTRA domain; Region: UTRA; cl01230 655816011471 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 655816011472 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 655816011473 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 655816011474 cofactor binding site; other site 655816011475 DNA binding site [nucleotide binding] 655816011476 substrate interaction site [chemical binding]; other site 655816011477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 655816011478 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 655816011479 PLD-like domain; Region: PLDc_2; pfam13091 655816011480 putative active site [active] 655816011481 catalytic site [active] 655816011482 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 655816011483 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 655816011484 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816011485 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 655816011486 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 655816011487 YyzF-like protein; Region: YyzF; cl15733 655816011488 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 655816011489 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 655816011490 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816011491 Coenzyme A binding pocket [chemical binding]; other site 655816011492 Tetratricopeptide repeat; Region: TPR_12; pfam13424 655816011493 Tetratricopeptide repeat; Region: TPR_12; pfam13424 655816011494 Arginase family; Region: Arginase; cl00306 655816011495 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 655816011496 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 655816011497 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 655816011498 inhibitor-cofactor binding pocket; inhibition site 655816011499 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655816011500 catalytic residue [active] 655816011501 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 655816011502 sensory histidine kinase AtoS; Provisional; Region: PRK11360 655816011503 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 655816011504 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655816011505 Walker A motif; other site 655816011506 ATP binding site [chemical binding]; other site 655816011507 Walker B motif; other site 655816011508 arginine finger; other site 655816011509 Helix-turn-helix domains; Region: HTH; cl00088 655816011510 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 655816011511 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 655816011512 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 655816011513 protein binding site [polypeptide binding]; other site 655816011514 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 655816011515 YycH protein; Region: YycI; cl02015 655816011516 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 655816011517 YycH protein; Region: YycH; pfam07435 655816011518 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 655816011519 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 655816011520 dimerization interface [polypeptide binding]; other site 655816011521 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 655816011522 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655816011523 dimer interface [polypeptide binding]; other site 655816011524 phosphorylation site [posttranslational modification] 655816011525 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655816011526 ATP binding site [chemical binding]; other site 655816011527 Mg2+ binding site [ion binding]; other site 655816011528 G-X-G motif; other site 655816011529 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 655816011530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655816011531 active site 655816011532 phosphorylation site [posttranslational modification] 655816011533 intermolecular recognition site; other site 655816011534 dimerization interface [polypeptide binding]; other site 655816011535 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655816011536 DNA binding site [nucleotide binding] 655816011537 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 655816011538 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 655816011539 GDP-binding site [chemical binding]; other site 655816011540 ACT binding site; other site 655816011541 IMP binding site; other site 655816011542 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 655816011543 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 655816011544 active site 655816011545 metal binding site [ion binding]; metal-binding site 655816011546 replicative DNA helicase; Provisional; Region: PRK05748 655816011547 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 655816011548 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 655816011549 Walker A motif; other site 655816011550 ATP binding site [chemical binding]; other site 655816011551 Walker B motif; other site 655816011552 DNA binding loops [nucleotide binding] 655816011553 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 655816011554 YycC-like protein; Region: YycC; pfam14174 655816011555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816011556 cyanate transporter; Region: CynX; TIGR00896 655816011557 putative substrate translocation pore; other site 655816011558 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 655816011559 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 655816011560 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 655816011561 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 655816011562 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 655816011563 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 655816011564 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 655816011565 DHH family; Region: DHH; pfam01368 655816011566 DHHA1 domain; Region: DHHA1; pfam02272 655816011567 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 655816011568 Coat F domain; Region: Coat_F; cl15836 655816011569 Helix-turn-helix domains; Region: HTH; cl00088 655816011570 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 655816011571 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 655816011572 DHHA2 domain; Region: DHHA2; pfam02833 655816011573 ANTAR domain; Region: ANTAR; cl04297 655816011574 D-galactonate transporter; Region: 2A0114; TIGR00893 655816011575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816011576 putative substrate translocation pore; other site 655816011577 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 655816011578 DNA binding residues [nucleotide binding] 655816011579 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 655816011580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816011581 putative substrate translocation pore; other site 655816011582 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655816011583 Helix-turn-helix domains; Region: HTH; cl00088 655816011584 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 655816011585 putative dimerization interface [polypeptide binding]; other site 655816011586 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816011587 Coenzyme A binding pocket [chemical binding]; other site 655816011588 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 655816011589 Helix-turn-helix domains; Region: HTH; cl00088 655816011590 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 655816011591 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655816011592 Helix-turn-helix domains; Region: HTH; cl00088 655816011593 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655816011594 Coenzyme A binding pocket [chemical binding]; other site 655816011595 Predicted membrane protein [Function unknown]; Region: COG2364 655816011596 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 655816011597 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 655816011598 catalytic residues [active] 655816011599 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 655816011600 CAAX protease self-immunity; Region: Abi; cl00558 655816011601 benzoate transport; Region: 2A0115; TIGR00895 655816011602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816011603 putative substrate translocation pore; other site 655816011604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655816011605 maltose O-acetyltransferase; Provisional; Region: PRK10092 655816011606 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 655816011607 active site 655816011608 substrate binding site [chemical binding]; other site 655816011609 trimer interface [polypeptide binding]; other site 655816011610 CoA binding site [chemical binding]; other site 655816011611 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 655816011612 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 655816011613 putative metal binding site [ion binding]; other site 655816011614 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655816011615 DNA binding site [nucleotide binding] 655816011616 domain linker motif; other site 655816011617 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 655816011618 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 655816011619 putative dimerization interface [polypeptide binding]; other site 655816011620 putative ligand binding site [chemical binding]; other site 655816011621 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 655816011622 active site 655816011623 DNA binding site [nucleotide binding] 655816011624 putative phosphate binding site [ion binding]; other site 655816011625 putative catalytic site [active] 655816011626 metal binding site A [ion binding]; metal-binding site 655816011627 AP binding site [nucleotide binding]; other site 655816011628 metal binding site B [ion binding]; metal-binding site 655816011629 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 655816011630 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 655816011631 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 655816011632 dimer interface [polypeptide binding]; other site 655816011633 ssDNA binding site [nucleotide binding]; other site 655816011634 tetramer (dimer of dimers) interface [polypeptide binding]; other site 655816011635 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 655816011636 GTP-binding protein YchF; Reviewed; Region: PRK09601 655816011637 YchF GTPase; Region: YchF; cd01900 655816011638 G1 box; other site 655816011639 GTP/Mg2+ binding site [chemical binding]; other site 655816011640 Switch I region; other site 655816011641 G2 box; other site 655816011642 Switch II region; other site 655816011643 G3 box; other site 655816011644 G4 box; other site 655816011645 G5 box; other site 655816011646 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 655816011647 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 655816011648 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 655816011649 putative [4Fe-4S] binding site [ion binding]; other site 655816011650 putative molybdopterin cofactor binding site [chemical binding]; other site 655816011651 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 655816011652 molybdopterin cofactor binding site; other site 655816011653 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 655816011654 Uncharacterized membrane protein [Function unknown]; Region: COG3949 655816011655 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 655816011656 ParB-like partition proteins; Region: parB_part; TIGR00180 655816011657 ParB-like nuclease domain; Region: ParBc; cl02129 655816011658 KorB domain; Region: KorB; pfam08535 655816011659 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 655816011660 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 655816011661 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 655816011662 ParB-like partition proteins; Region: parB_part; TIGR00180 655816011663 ParB-like nuclease domain; Region: ParBc; cl02129 655816011664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655816011665 S-adenosylmethionine binding site [chemical binding]; other site 655816011666 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 655816011667 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655816011668 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 655816011669 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 655816011670 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 655816011671 trmE is a tRNA modification GTPase; Region: trmE; cd04164 655816011672 G1 box; other site 655816011673 GTP/Mg2+ binding site [chemical binding]; other site 655816011674 Switch I region; other site 655816011675 G2 box; other site 655816011676 Switch II region; other site 655816011677 G3 box; other site 655816011678 G4 box; other site 655816011679 G5 box; other site 655816011680 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 655816011681 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 655816011682 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 655816011683 G-X-X-G motif; other site 655816011684 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 655816011685 RxxxH motif; other site 655816011686 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 655816011687 Ribonuclease P; Region: Ribonuclease_P; cl00457 655816011688 Ribosomal protein L34; Region: Ribosomal_L34; cl00370