-- dump date 20111121_010519 -- class Genbank::misc_feature -- table misc_feature_note -- id note 714359000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 714359000002 hypothetical protein; Validated; Region: PRK06672 714359000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359000004 Walker A motif; other site 714359000005 ATP binding site [chemical binding]; other site 714359000006 Walker B motif; other site 714359000007 arginine finger; other site 714359000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 714359000009 DnaA box-binding interface [nucleotide binding]; other site 714359000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 714359000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 714359000012 putative DNA binding surface [nucleotide binding]; other site 714359000013 dimer interface [polypeptide binding]; other site 714359000014 beta-clamp/clamp loader binding surface; other site 714359000015 beta-clamp/translesion DNA polymerase binding surface; other site 714359000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 714359000017 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 714359000018 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 714359000019 Walker A/P-loop; other site 714359000020 ATP binding site [chemical binding]; other site 714359000021 Q-loop/lid; other site 714359000022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359000023 ABC transporter signature motif; other site 714359000024 Walker B; other site 714359000025 D-loop; other site 714359000026 H-loop/switch region; other site 714359000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 714359000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359000029 Mg2+ binding site [ion binding]; other site 714359000030 G-X-G motif; other site 714359000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 714359000032 anchoring element; other site 714359000033 dimer interface [polypeptide binding]; other site 714359000034 ATP binding site [chemical binding]; other site 714359000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 714359000036 active site 714359000037 putative metal-binding site [ion binding]; other site 714359000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 714359000039 DNA gyrase subunit A; Validated; Region: PRK05560 714359000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 714359000041 CAP-like domain; other site 714359000042 active site 714359000043 primary dimer interface [polypeptide binding]; other site 714359000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 714359000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 714359000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 714359000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 714359000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 714359000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 714359000050 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 714359000051 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 714359000052 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 714359000053 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 714359000054 active site 714359000055 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 714359000056 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359000057 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 714359000058 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 714359000059 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 714359000060 active site 714359000061 multimer interface [polypeptide binding]; other site 714359000062 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 714359000063 predicted active site [active] 714359000064 catalytic triad [active] 714359000065 seryl-tRNA synthetase; Provisional; Region: PRK05431 714359000066 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 714359000067 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 714359000068 dimer interface [polypeptide binding]; other site 714359000069 active site 714359000070 motif 1; other site 714359000071 motif 2; other site 714359000072 motif 3; other site 714359000073 Domain of unknown function (DUF3797); Region: DUF3797; pfam12677 714359000074 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 714359000075 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 714359000076 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 714359000077 Substrate-binding site [chemical binding]; other site 714359000078 Substrate specificity [chemical binding]; other site 714359000079 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 714359000080 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 714359000081 Substrate-binding site [chemical binding]; other site 714359000082 Substrate specificity [chemical binding]; other site 714359000083 Isochorismatase family; Region: Isochorismatase; pfam00857 714359000084 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 714359000085 catalytic triad [active] 714359000086 conserved cis-peptide bond; other site 714359000087 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 714359000088 nucleoside/Zn binding site; other site 714359000089 dimer interface [polypeptide binding]; other site 714359000090 catalytic motif [active] 714359000091 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 714359000092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359000093 Walker A motif; other site 714359000094 ATP binding site [chemical binding]; other site 714359000095 Walker B motif; other site 714359000096 arginine finger; other site 714359000097 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 714359000098 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 714359000099 recombination protein RecR; Reviewed; Region: recR; PRK00076 714359000100 RecR protein; Region: RecR; pfam02132 714359000101 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 714359000102 putative active site [active] 714359000103 putative metal-binding site [ion binding]; other site 714359000104 tetramer interface [polypeptide binding]; other site 714359000105 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 714359000106 SigmaK-factor processing regulatory protein BofA; Region: BofA; cl06466 714359000107 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 714359000108 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 714359000109 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 714359000110 homodimer interface [polypeptide binding]; other site 714359000111 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359000112 catalytic residue [active] 714359000113 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 714359000114 thymidylate kinase; Validated; Region: tmk; PRK00698 714359000115 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 714359000116 TMP-binding site; other site 714359000117 ATP-binding site [chemical binding]; other site 714359000118 DNA polymerase III subunit delta'; Validated; Region: PRK08058 714359000119 PSP1 C-terminal conserved region; Region: PSP1; cl00770 714359000120 Protein of unknown function (DUF972); Region: DUF972; cl01853 714359000121 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 714359000122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359000123 S-adenosylmethionine binding site [chemical binding]; other site 714359000124 Predicted methyltransferases [General function prediction only]; Region: COG0313 714359000125 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 714359000126 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 714359000127 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 714359000128 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 714359000129 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 714359000130 active site 714359000131 HIGH motif; other site 714359000132 KMSKS motif; other site 714359000133 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 714359000134 tRNA binding surface [nucleotide binding]; other site 714359000135 anticodon binding site; other site 714359000136 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 714359000137 dimer interface [polypeptide binding]; other site 714359000138 putative tRNA-binding site [nucleotide binding]; other site 714359000139 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 714359000140 active site 714359000141 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 714359000142 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 714359000143 putative active site [active] 714359000144 putative metal binding site [ion binding]; other site 714359000145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 714359000146 YabG peptidase U57; Region: Peptidase_U57; cl05250 714359000147 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 714359000148 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 714359000149 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK04181 714359000150 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 714359000151 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 714359000152 pur operon repressor; Provisional; Region: PRK09213 714359000153 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 714359000154 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 714359000155 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 714359000156 homotrimer interaction site [polypeptide binding]; other site 714359000157 putative active site [active] 714359000158 SpoVG; Region: SpoVG; cl00915 714359000159 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 714359000160 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 714359000161 Substrate binding site; other site 714359000162 Mg++ binding site; other site 714359000163 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 714359000164 active site 714359000165 substrate binding site [chemical binding]; other site 714359000166 CoA binding site [chemical binding]; other site 714359000167 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 714359000168 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 714359000169 putative active site [active] 714359000170 catalytic residue [active] 714359000171 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 714359000172 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 714359000173 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 714359000174 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714359000175 ATP binding site [chemical binding]; other site 714359000176 putative Mg++ binding site [ion binding]; other site 714359000177 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714359000178 nucleotide binding region [chemical binding]; other site 714359000179 ATP-binding site [chemical binding]; other site 714359000180 TRCF domain; Region: TRCF; cl04088 714359000181 stage V sporulation protein T; Region: spore_V_T; TIGR02851 714359000182 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 714359000183 stage V sporulation protein B; Region: spore_V_B; TIGR02900 714359000184 MatE; Region: MatE; cl10513 714359000185 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 714359000186 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 714359000187 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 714359000188 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 714359000189 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714359000190 RNA binding surface [nucleotide binding]; other site 714359000191 YabP family; Region: YabP; cl06766 714359000192 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 714359000193 Septum formation initiator; Region: DivIC; cl11433 714359000194 hypothetical protein; Provisional; Region: PRK08582 714359000195 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 714359000196 RNA binding site [nucleotide binding]; other site 714359000197 stage II sporulation protein E; Region: spore_II_E; TIGR02865 714359000198 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 714359000199 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 714359000200 Ligand Binding Site [chemical binding]; other site 714359000201 TilS substrate binding domain; Region: TilS; pfam09179 714359000202 B3/4 domain; Region: B3_4; cl11458 714359000203 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 714359000204 FtsH Extracellular; Region: FtsH_ext; pfam06480 714359000205 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 714359000206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359000207 Walker A motif; other site 714359000208 ATP binding site [chemical binding]; other site 714359000209 Walker B motif; other site 714359000210 arginine finger; other site 714359000211 Peptidase family M41; Region: Peptidase_M41; pfam01434 714359000212 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 714359000213 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 714359000214 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 714359000215 dimerization interface [polypeptide binding]; other site 714359000216 domain crossover interface; other site 714359000217 redox-dependent activation switch; other site 714359000218 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 714359000219 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 714359000220 dimer interface [polypeptide binding]; other site 714359000221 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359000222 catalytic residue [active] 714359000223 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 714359000224 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 714359000225 chorismate binding enzyme; Region: Chorismate_bind; cl10555 714359000226 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 714359000227 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 714359000228 glutamine binding [chemical binding]; other site 714359000229 catalytic triad [active] 714359000230 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 714359000231 homodimer interface [polypeptide binding]; other site 714359000232 substrate-cofactor binding pocket; other site 714359000233 Aminotransferase class IV; Region: Aminotran_4; pfam01063 714359000234 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359000235 catalytic residue [active] 714359000236 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 714359000237 dihydropteroate synthase; Region: DHPS; TIGR01496 714359000238 substrate binding pocket [chemical binding]; other site 714359000239 dimer interface [polypeptide binding]; other site 714359000240 inhibitor binding site; inhibition site 714359000241 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 714359000242 homooctamer interface [polypeptide binding]; other site 714359000243 active site 714359000244 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 714359000245 catalytic center binding site [active] 714359000246 ATP binding site [chemical binding]; other site 714359000247 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359000248 non-specific DNA binding site [nucleotide binding]; other site 714359000249 salt bridge; other site 714359000250 sequence-specific DNA binding site [nucleotide binding]; other site 714359000251 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 714359000252 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 714359000253 phosphate binding site [ion binding]; other site 714359000254 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 714359000255 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 714359000256 dimer interface [polypeptide binding]; other site 714359000257 putative anticodon binding site; other site 714359000258 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 714359000259 motif 1; other site 714359000260 active site 714359000261 motif 2; other site 714359000262 motif 3; other site 714359000263 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 714359000264 UvrB/uvrC motif; Region: UVR; pfam02151 714359000265 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 714359000266 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 714359000267 ADP binding site [chemical binding]; other site 714359000268 phosphagen binding site; other site 714359000269 substrate specificity loop; other site 714359000270 Clp protease ATP binding subunit; Region: clpC; CHL00095 714359000271 Clp amino terminal domain; Region: Clp_N; pfam02861 714359000272 Clp amino terminal domain; Region: Clp_N; pfam02861 714359000273 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359000274 Walker A motif; other site 714359000275 ATP binding site [chemical binding]; other site 714359000276 Walker B motif; other site 714359000277 arginine finger; other site 714359000278 UvrB/uvrC motif; Region: UVR; pfam02151 714359000279 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359000280 Walker A motif; other site 714359000281 ATP binding site [chemical binding]; other site 714359000282 Walker B motif; other site 714359000283 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 714359000284 DNA repair protein RadA; Provisional; Region: PRK11823 714359000285 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 714359000286 Walker A motif/ATP binding site; other site 714359000287 ATP binding site [chemical binding]; other site 714359000288 Walker B motif; other site 714359000289 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 714359000290 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 714359000291 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 714359000292 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 714359000293 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 714359000294 putative active site [active] 714359000295 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 714359000296 substrate binding site; other site 714359000297 dimer interface; other site 714359000298 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 714359000299 homotrimer interaction site [polypeptide binding]; other site 714359000300 zinc binding site [ion binding]; other site 714359000301 CDP-binding sites; other site 714359000302 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 714359000303 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 714359000304 active site 714359000305 HIGH motif; other site 714359000306 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 714359000307 active site 714359000308 KMSKS motif; other site 714359000309 serine O-acetyltransferase; Region: cysE; TIGR01172 714359000310 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 714359000311 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 714359000312 trimer interface [polypeptide binding]; other site 714359000313 active site 714359000314 substrate binding site [chemical binding]; other site 714359000315 CoA binding site [chemical binding]; other site 714359000316 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 714359000317 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 714359000318 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 714359000319 KMSKS motif; other site 714359000320 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 714359000321 tRNA binding surface [nucleotide binding]; other site 714359000322 anticodon binding site; other site 714359000323 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 714359000324 active site 714359000325 metal binding site [ion binding]; metal-binding site 714359000326 dimerization interface [polypeptide binding]; other site 714359000327 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 714359000328 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 714359000329 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 714359000330 YacP-like NYN domain; Region: NYN_YacP; cl01491 714359000331 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 714359000332 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359000333 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 714359000334 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 714359000335 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 714359000336 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 714359000337 putative homodimer interface [polypeptide binding]; other site 714359000338 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 714359000339 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 714359000340 23S rRNA interface [nucleotide binding]; other site 714359000341 L7/L12 interface [polypeptide binding]; other site 714359000342 putative thiostrepton binding site; other site 714359000343 L25 interface [polypeptide binding]; other site 714359000344 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 714359000345 mRNA/rRNA interface [nucleotide binding]; other site 714359000346 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 714359000347 23S rRNA interface [nucleotide binding]; other site 714359000348 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 714359000349 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 714359000350 core dimer interface [polypeptide binding]; other site 714359000351 peripheral dimer interface [polypeptide binding]; other site 714359000352 L10 interface [polypeptide binding]; other site 714359000353 L11 interface [polypeptide binding]; other site 714359000354 putative EF-Tu interaction site [polypeptide binding]; other site 714359000355 putative EF-G interaction site [polypeptide binding]; other site 714359000356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359000357 S-adenosylmethionine binding site [chemical binding]; other site 714359000358 RNA polymerase beta subunit; Provisional; Region: rpoB; CHL00207 714359000359 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 714359000360 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 714359000361 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 714359000362 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 714359000363 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 714359000364 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 714359000365 RPB10 interaction site [polypeptide binding]; other site 714359000366 RPB1 interaction site [polypeptide binding]; other site 714359000367 RPB11 interaction site [polypeptide binding]; other site 714359000368 RPB3 interaction site [polypeptide binding]; other site 714359000369 RPB12 interaction site [polypeptide binding]; other site 714359000370 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 714359000371 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 714359000372 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 714359000373 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 714359000374 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 714359000375 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 714359000376 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 714359000377 G-loop; other site 714359000378 DNA binding site [nucleotide binding] 714359000379 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 714359000380 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 714359000381 S17 interaction site [polypeptide binding]; other site 714359000382 S8 interaction site; other site 714359000383 16S rRNA interaction site [nucleotide binding]; other site 714359000384 streptomycin interaction site [chemical binding]; other site 714359000385 23S rRNA interaction site [nucleotide binding]; other site 714359000386 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 714359000387 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 714359000388 elongation factor G; Reviewed; Region: PRK00007 714359000389 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved so...; Region: EF-G; cd01886 714359000390 G1 box; other site 714359000391 putative GEF interaction site [polypeptide binding]; other site 714359000392 GTP/Mg2+ binding site [chemical binding]; other site 714359000393 Switch I region; other site 714359000394 G2 box; other site 714359000395 G3 box; other site 714359000396 Switch II region; other site 714359000397 G4 box; other site 714359000398 G5 box; other site 714359000399 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 714359000400 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 714359000401 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 714359000402 elongation factor Tu; Reviewed; Region: PRK00049 714359000403 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 714359000404 G1 box; other site 714359000405 GEF interaction site [polypeptide binding]; other site 714359000406 GTP/Mg2+ binding site [chemical binding]; other site 714359000407 Switch I region; other site 714359000408 G2 box; other site 714359000409 G3 box; other site 714359000410 Switch II region; other site 714359000411 G4 box; other site 714359000412 G5 box; other site 714359000413 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 714359000414 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 714359000415 Antibiotic Binding Site [chemical binding]; other site 714359000416 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 714359000417 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 714359000418 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 714359000419 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 714359000420 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 714359000421 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 714359000422 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 714359000423 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 714359000424 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 714359000425 putative translocon binding site; other site 714359000426 protein-rRNA interface [nucleotide binding]; other site 714359000427 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 714359000428 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 714359000429 G-X-X-G motif; other site 714359000430 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 714359000431 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 714359000432 23S rRNA interface [nucleotide binding]; other site 714359000433 5S rRNA interface [nucleotide binding]; other site 714359000434 putative antibiotic binding site [chemical binding]; other site 714359000435 L25 interface [polypeptide binding]; other site 714359000436 L27 interface [polypeptide binding]; other site 714359000437 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 714359000438 23S rRNA interface [nucleotide binding]; other site 714359000439 putative translocon interaction site; other site 714359000440 signal recognition particle (SRP54) interaction site; other site 714359000441 L23 interface [polypeptide binding]; other site 714359000442 trigger factor interaction site; other site 714359000443 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 714359000444 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 714359000445 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 714359000446 KOW motif; Region: KOW; cl00354 714359000447 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 714359000448 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 714359000449 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 714359000450 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 714359000451 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 714359000452 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 714359000453 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 714359000454 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 714359000455 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 714359000456 5S rRNA interface [nucleotide binding]; other site 714359000457 L27 interface [polypeptide binding]; other site 714359000458 23S rRNA interface [nucleotide binding]; other site 714359000459 L5 interface [polypeptide binding]; other site 714359000460 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 714359000461 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 714359000462 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 714359000463 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 714359000464 23S rRNA binding site [nucleotide binding]; other site 714359000465 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 714359000466 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 714359000467 SecY translocase; Region: SecY; pfam00344 714359000468 adenylate kinase; Reviewed; Region: adk; PRK00279 714359000469 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 714359000470 AMP-binding site [chemical binding]; other site 714359000471 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 714359000472 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 714359000473 active site 714359000474 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 714359000475 rRNA binding site [nucleotide binding]; other site 714359000476 predicted 30S ribosome binding site; other site 714359000477 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 714359000478 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 714359000479 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 714359000480 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 714359000481 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 714359000482 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 714359000483 alphaNTD - beta interaction site [polypeptide binding]; other site 714359000484 alphaNTD homodimer interface [polypeptide binding]; other site 714359000485 alphaNTD - beta' interaction site [polypeptide binding]; other site 714359000486 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 714359000487 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 714359000488 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 714359000489 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 714359000490 Walker A/P-loop; other site 714359000491 ATP binding site [chemical binding]; other site 714359000492 Q-loop/lid; other site 714359000493 ABC transporter signature motif; other site 714359000494 Walker B; other site 714359000495 D-loop; other site 714359000496 H-loop/switch region; other site 714359000497 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 714359000498 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 714359000499 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 714359000500 Walker A/P-loop; other site 714359000501 ATP binding site [chemical binding]; other site 714359000502 Q-loop/lid; other site 714359000503 ABC transporter signature motif; other site 714359000504 Walker B; other site 714359000505 D-loop; other site 714359000506 H-loop/switch region; other site 714359000507 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 714359000508 Cobalt transport protein; Region: CbiQ; cl00463 714359000509 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 714359000510 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 714359000511 dimerization interface 3.5A [polypeptide binding]; other site 714359000512 active site 714359000513 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 714359000514 23S rRNA interface [nucleotide binding]; other site 714359000515 L3 interface [polypeptide binding]; other site 714359000516 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 714359000517 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 714359000518 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 714359000519 active site 714359000520 metal binding site [ion binding]; metal-binding site 714359000521 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 714359000522 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 714359000523 Glycerate kinase family; Region: Gly_kinase; cl00841 714359000524 Arginase family; Region: Arginase; cl00306 714359000525 Uncharacterized conserved protein [Function unknown]; Region: COG1624 714359000526 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 714359000527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 714359000528 YbbR-like protein; Region: YbbR; pfam07949 714359000529 YbbR-like protein; Region: YbbR; pfam07949 714359000530 YbbR-like protein; Region: YbbR; pfam07949 714359000531 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 714359000532 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 714359000533 active site 714359000534 substrate binding site [chemical binding]; other site 714359000535 metal binding site [ion binding]; metal-binding site 714359000536 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 714359000537 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 714359000538 glutaminase active site [active] 714359000539 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 714359000540 dimer interface [polypeptide binding]; other site 714359000541 active site 714359000542 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 714359000543 dimer interface [polypeptide binding]; other site 714359000544 active site 714359000545 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 714359000546 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 714359000547 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 714359000548 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359000549 classical (c) SDRs; Region: SDR_c; cd05233 714359000550 NAD(P) binding site [chemical binding]; other site 714359000551 active site 714359000552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359000553 ABC-ATPase subunit interface; other site 714359000554 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 714359000555 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 714359000556 Walker A/P-loop; other site 714359000557 ATP binding site [chemical binding]; other site 714359000558 Q-loop/lid; other site 714359000559 ABC transporter signature motif; other site 714359000560 Walker B; other site 714359000561 D-loop; other site 714359000562 H-loop/switch region; other site 714359000563 NIL domain; Region: NIL; cl09633 714359000564 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 714359000565 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 714359000566 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 714359000567 putative NAD(P) binding site [chemical binding]; other site 714359000568 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 714359000569 FAD binding domain; Region: FAD_binding_4; pfam01565 714359000570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359000571 putative substrate translocation pore; other site 714359000572 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 714359000573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359000574 putative substrate translocation pore; other site 714359000575 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 714359000576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359000577 dimer interface [polypeptide binding]; other site 714359000578 conserved gate region; other site 714359000579 putative PBP binding loops; other site 714359000580 ABC-ATPase subunit interface; other site 714359000581 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 714359000582 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 714359000583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359000584 dimer interface [polypeptide binding]; other site 714359000585 conserved gate region; other site 714359000586 putative PBP binding loops; other site 714359000587 ABC-ATPase subunit interface; other site 714359000588 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 714359000589 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 714359000590 Walker A/P-loop; other site 714359000591 ATP binding site [chemical binding]; other site 714359000592 Q-loop/lid; other site 714359000593 ABC transporter signature motif; other site 714359000594 Walker B; other site 714359000595 D-loop; other site 714359000596 H-loop/switch region; other site 714359000597 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 714359000598 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 714359000599 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 714359000600 Walker A/P-loop; other site 714359000601 ATP binding site [chemical binding]; other site 714359000602 Q-loop/lid; other site 714359000603 ABC transporter signature motif; other site 714359000604 Walker B; other site 714359000605 D-loop; other site 714359000606 H-loop/switch region; other site 714359000607 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 714359000608 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 714359000609 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 714359000610 peptide binding site [polypeptide binding]; other site 714359000611 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714359000612 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 714359000613 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714359000614 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 714359000615 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 714359000616 peptide binding site [polypeptide binding]; other site 714359000617 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 714359000618 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 714359000619 peptide binding site [polypeptide binding]; other site 714359000620 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 714359000621 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 714359000622 active site 714359000623 catalytic tetrad [active] 714359000624 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359000625 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 714359000626 Sugar transport protein; Region: Sugar_transport; pfam06800 714359000627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359000628 dimer interface [polypeptide binding]; other site 714359000629 conserved gate region; other site 714359000630 putative PBP binding loops; other site 714359000631 ABC-ATPase subunit interface; other site 714359000632 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 714359000633 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 714359000634 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 714359000635 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 714359000636 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714359000637 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359000638 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 714359000639 putative dimerization interface [polypeptide binding]; other site 714359000640 EamA-like transporter family; Region: EamA; cl01037 714359000641 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 714359000642 putative acyl-acceptor binding pocket; other site 714359000643 Transcriptional regulators [Transcription]; Region: PurR; COG1609 714359000644 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 714359000645 DNA binding site [nucleotide binding] 714359000646 domain linker motif; other site 714359000647 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 714359000648 putative ligand binding site [chemical binding]; other site 714359000649 putative dimerization interface [polypeptide binding]; other site 714359000650 Uncharacterized conserved protein [Function unknown]; Region: COG1284 714359000651 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 714359000652 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 714359000653 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 714359000654 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 714359000655 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 714359000656 active site 714359000657 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5298 714359000658 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 714359000659 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 714359000660 N-acetyl-D-glucosamine binding site [chemical binding]; other site 714359000661 catalytic residue [active] 714359000662 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 714359000663 nucleotide binding site/active site [active] 714359000664 HIT family signature motif; other site 714359000665 catalytic residue [active] 714359000666 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 714359000667 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 714359000668 ABC transporter; Region: ABC_tran_2; pfam12848 714359000669 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 714359000670 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 714359000671 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 714359000672 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 714359000673 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 714359000674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359000675 dimer interface [polypeptide binding]; other site 714359000676 conserved gate region; other site 714359000677 putative PBP binding loops; other site 714359000678 ABC-ATPase subunit interface; other site 714359000679 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 714359000680 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 714359000681 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359000682 dimer interface [polypeptide binding]; other site 714359000683 conserved gate region; other site 714359000684 putative PBP binding loops; other site 714359000685 ABC-ATPase subunit interface; other site 714359000686 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 714359000687 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 714359000688 Walker A/P-loop; other site 714359000689 ATP binding site [chemical binding]; other site 714359000690 Q-loop/lid; other site 714359000691 ABC transporter signature motif; other site 714359000692 Walker B; other site 714359000693 D-loop; other site 714359000694 H-loop/switch region; other site 714359000695 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 714359000696 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 714359000697 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 714359000698 Walker A/P-loop; other site 714359000699 ATP binding site [chemical binding]; other site 714359000700 Q-loop/lid; other site 714359000701 ABC transporter signature motif; other site 714359000702 Walker B; other site 714359000703 D-loop; other site 714359000704 H-loop/switch region; other site 714359000705 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 714359000706 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359000707 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 714359000708 active site 714359000709 motif I; other site 714359000710 motif II; other site 714359000711 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359000712 motif II; other site 714359000713 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 714359000714 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 714359000715 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 714359000716 dimer interface [polypeptide binding]; other site 714359000717 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 714359000718 active site 714359000719 Fe binding site [ion binding]; other site 714359000720 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 714359000721 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 714359000722 Cupin domain; Region: Cupin_2; cl09118 714359000723 Amino acid permease; Region: AA_permease; cl00524 714359000724 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 714359000725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359000726 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359000727 putative substrate translocation pore; other site 714359000728 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 714359000729 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 714359000730 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 714359000731 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 714359000732 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 714359000733 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 714359000734 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 714359000735 helicase 45; Provisional; Region: PTZ00424 714359000736 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 714359000737 ATP binding site [chemical binding]; other site 714359000738 Mg++ binding site [ion binding]; other site 714359000739 motif III; other site 714359000740 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714359000741 nucleotide binding region [chemical binding]; other site 714359000742 ATP-binding site [chemical binding]; other site 714359000743 UV-endonuclease UvdE; Region: UvdE; cl10036 714359000744 Rhomboid family; Region: Rhomboid; cl11446 714359000745 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 714359000746 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 714359000747 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 714359000748 alanine racemase; Reviewed; Region: alr; PRK00053 714359000749 active site 714359000750 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 714359000751 dimer interface [polypeptide binding]; other site 714359000752 substrate binding site [chemical binding]; other site 714359000753 catalytic residues [active] 714359000754 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 714359000755 PemK-like protein; Region: PemK; cl00995 714359000756 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 714359000757 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 714359000758 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 714359000759 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 714359000760 RNA binding site [nucleotide binding]; other site 714359000761 hypothetical protein; Provisional; Region: PRK04351 714359000762 SprT homologues; Region: SprT; cl01182 714359000763 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 714359000764 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 714359000765 Glycoprotease family; Region: Peptidase_M22; pfam00814 714359000766 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 714359000767 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359000768 Coenzyme A binding pocket [chemical binding]; other site 714359000769 UGMP family protein; Validated; Region: PRK09604 714359000770 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 714359000771 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 714359000772 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 714359000773 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359000774 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 714359000775 ABC transporter; Region: ABC_tran_2; pfam12848 714359000776 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 714359000777 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 714359000778 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 714359000779 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359000780 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 714359000781 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 714359000782 oligomerisation interface [polypeptide binding]; other site 714359000783 mobile loop; other site 714359000784 roof hairpin; other site 714359000785 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 714359000786 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 714359000787 ring oligomerisation interface [polypeptide binding]; other site 714359000788 ATP/Mg binding site [chemical binding]; other site 714359000789 stacking interactions; other site 714359000790 hinge regions; other site 714359000791 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 714359000792 putative active site [active] 714359000793 putative NTP binding site [chemical binding]; other site 714359000794 putative nucleic acid binding site [nucleotide binding]; other site 714359000795 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 714359000796 putative active site [active] 714359000797 putative NTP binding site [chemical binding]; other site 714359000798 putative nucleic acid binding site [nucleotide binding]; other site 714359000799 GMP synthase; Reviewed; Region: guaA; PRK00074 714359000800 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 714359000801 AMP/PPi binding site [chemical binding]; other site 714359000802 candidate oxyanion hole; other site 714359000803 catalytic triad [active] 714359000804 potential glutamine specificity residues [chemical binding]; other site 714359000805 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 714359000806 ATP Binding subdomain [chemical binding]; other site 714359000807 Ligand Binding sites [chemical binding]; other site 714359000808 Dimerization subdomain; other site 714359000809 Permease family; Region: Xan_ur_permease; cl00967 714359000810 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359000811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359000812 active site 714359000813 phosphorylation site [posttranslational modification] 714359000814 intermolecular recognition site; other site 714359000815 dimerization interface [polypeptide binding]; other site 714359000816 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359000817 DNA binding site [nucleotide binding] 714359000818 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359000819 dimerization interface [polypeptide binding]; other site 714359000820 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359000821 dimer interface [polypeptide binding]; other site 714359000822 phosphorylation site [posttranslational modification] 714359000823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359000824 ATP binding site [chemical binding]; other site 714359000825 Mg2+ binding site [ion binding]; other site 714359000826 G-X-G motif; other site 714359000827 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 714359000828 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 714359000829 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 714359000830 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 714359000831 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 714359000832 catalytic residues [active] 714359000833 Bacitracin resistance protein BacA; Region: BacA; cl00858 714359000834 ABC-2 type transporter; Region: ABC2_membrane; cl11417 714359000835 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 714359000836 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 714359000837 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 714359000838 Walker A/P-loop; other site 714359000839 ATP binding site [chemical binding]; other site 714359000840 Q-loop/lid; other site 714359000841 ABC transporter signature motif; other site 714359000842 Walker B; other site 714359000843 D-loop; other site 714359000844 H-loop/switch region; other site 714359000845 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359000846 dimer interface [polypeptide binding]; other site 714359000847 phosphorylation site [posttranslational modification] 714359000848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359000849 ATP binding site [chemical binding]; other site 714359000850 Mg2+ binding site [ion binding]; other site 714359000851 G-X-G motif; other site 714359000852 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359000853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359000854 active site 714359000855 phosphorylation site [posttranslational modification] 714359000856 intermolecular recognition site; other site 714359000857 dimerization interface [polypeptide binding]; other site 714359000858 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359000859 DNA binding site [nucleotide binding] 714359000860 Rhamnan synthesis protein F; Region: RgpF; cl01529 714359000861 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359000862 S-adenosylmethionine binding site [chemical binding]; other site 714359000863 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359000864 S-adenosylmethionine binding site [chemical binding]; other site 714359000865 Sulfotransferase family; Region: Sulfotransfer_2; cl12149 714359000866 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 714359000867 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359000868 NAD(P) binding site [chemical binding]; other site 714359000869 active site 714359000870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359000871 S-adenosylmethionine binding site [chemical binding]; other site 714359000872 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 714359000873 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 714359000874 active site 714359000875 EamA-like transporter family; Region: EamA; cl01037 714359000876 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 714359000877 EamA-like transporter family; Region: EamA; cl01037 714359000878 Sulfotransferase family; Region: Sulfotransfer_2; cl12149 714359000879 AIR carboxylase; Region: AIRC; cl00310 714359000880 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 714359000881 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 714359000882 adenylosuccinate lyase; Provisional; Region: PRK07492 714359000883 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 714359000884 tetramer interface [polypeptide binding]; other site 714359000885 active site 714359000886 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 714359000887 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 714359000888 ATP binding site [chemical binding]; other site 714359000889 active site 714359000890 substrate binding site [chemical binding]; other site 714359000891 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 714359000892 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 714359000893 putative active site [active] 714359000894 catalytic triad [active] 714359000895 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 714359000896 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 714359000897 dimerization interface [polypeptide binding]; other site 714359000898 ATP binding site [chemical binding]; other site 714359000899 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 714359000900 dimerization interface [polypeptide binding]; other site 714359000901 ATP binding site [chemical binding]; other site 714359000902 amidophosphoribosyltransferase; Provisional; Region: PRK06781 714359000903 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 714359000904 active site 714359000905 tetramer interface [polypeptide binding]; other site 714359000906 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 714359000907 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 714359000908 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 714359000909 dimerization interface [polypeptide binding]; other site 714359000910 putative ATP binding site [chemical binding]; other site 714359000911 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 714359000912 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 714359000913 active site 714359000914 substrate binding site [chemical binding]; other site 714359000915 cosubstrate binding site; other site 714359000916 catalytic site [active] 714359000917 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 714359000918 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 714359000919 purine monophosphate binding site [chemical binding]; other site 714359000920 dimer interface [polypeptide binding]; other site 714359000921 putative catalytic residues [active] 714359000922 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 714359000923 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 714359000924 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 714359000925 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 714359000926 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 714359000927 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 714359000928 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 714359000929 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 714359000930 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 714359000931 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 714359000932 substrate binding site [chemical binding]; other site 714359000933 putative active site [active] 714359000934 dimer interface [polypeptide binding]; other site 714359000935 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 714359000936 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359000937 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 714359000938 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 714359000939 nucleotide binding pocket [chemical binding]; other site 714359000940 K-X-D-G motif; other site 714359000941 catalytic site [active] 714359000942 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 714359000943 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 714359000944 Dimer interface [polypeptide binding]; other site 714359000945 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 714359000946 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 714359000947 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 714359000948 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 714359000949 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 714359000950 Glutamate binding site [chemical binding]; other site 714359000951 homodimer interface [polypeptide binding]; other site 714359000952 NAD binding site [chemical binding]; other site 714359000953 catalytic residues [active] 714359000954 Isochorismatase family; Region: Isochorismatase; pfam00857 714359000955 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 714359000956 catalytic triad [active] 714359000957 conserved cis-peptide bond; other site 714359000958 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 714359000959 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 714359000960 Walker A/P-loop; other site 714359000961 ATP binding site [chemical binding]; other site 714359000962 Q-loop/lid; other site 714359000963 ABC transporter signature motif; other site 714359000964 Walker B; other site 714359000965 D-loop; other site 714359000966 H-loop/switch region; other site 714359000967 NIL domain; Region: NIL; cl09633 714359000968 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359000969 dimer interface [polypeptide binding]; other site 714359000970 conserved gate region; other site 714359000971 ABC-ATPase subunit interface; other site 714359000972 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 714359000973 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 714359000974 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359000975 ATP binding site [chemical binding]; other site 714359000976 dimerization interface [polypeptide binding]; other site 714359000977 Metal binding site [ion binding]; metal-binding site 714359000978 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 714359000979 putative dimer interface [polypeptide binding]; other site 714359000980 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359000981 yiaA/B two helix domain; Region: YiaAB; cl01759 714359000982 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 714359000983 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 714359000984 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 714359000985 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 714359000986 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 714359000987 GatB domain; Region: GatB_Yqey; cl11497 714359000988 putative lipid kinase; Reviewed; Region: PRK13337 714359000989 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 714359000990 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 714359000991 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359000992 motif II; other site 714359000993 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 714359000994 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 714359000995 inhibitor-cofactor binding pocket; inhibition site 714359000996 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359000997 catalytic residue [active] 714359000998 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 714359000999 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 714359001000 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359001001 Walker A motif; other site 714359001002 ATP binding site [chemical binding]; other site 714359001003 Walker B motif; other site 714359001004 arginine finger; other site 714359001005 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 714359001006 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 714359001007 tetramerization interface [polypeptide binding]; other site 714359001008 NAD(P) binding site [chemical binding]; other site 714359001009 catalytic residues [active] 714359001010 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 714359001011 Telomeric repeat-binding factor 2; Region: TRF2; pfam11611 714359001012 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 714359001013 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 714359001014 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 714359001015 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 714359001016 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 714359001017 TRAM domain; Region: TRAM; cl01282 714359001018 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 714359001019 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359001020 S-adenosylmethionine binding site [chemical binding]; other site 714359001021 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 714359001022 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 714359001023 FMN binding site [chemical binding]; other site 714359001024 active site 714359001025 catalytic residues [active] 714359001026 substrate binding site [chemical binding]; other site 714359001027 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 714359001028 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 714359001029 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 714359001030 Protein of unknown function DUF45; Region: DUF45; cl00636 714359001031 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 714359001032 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 714359001033 active site 714359001034 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 714359001035 Na+/H+ antiporter family; Region: Na_H_antiporter; cl15356 714359001036 Na+/H+ antiporter family; Region: Na_H_antiporter; cl15356 714359001037 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 714359001038 amidohydrolase; Region: amidohydrolases; TIGR01891 714359001039 metal binding site [ion binding]; metal-binding site 714359001040 putative dimer interface [polypeptide binding]; other site 714359001041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359001042 S-adenosylmethionine binding site [chemical binding]; other site 714359001043 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 714359001044 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 714359001045 catalytic residue [active] 714359001046 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 714359001047 catalytic residues [active] 714359001048 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359001049 peroxiredoxin; Region: AhpC; TIGR03137 714359001050 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 714359001051 dimer interface [polypeptide binding]; other site 714359001052 decamer (pentamer of dimers) interface [polypeptide binding]; other site 714359001053 catalytic triad [active] 714359001054 peroxidatic and resolving cysteines [active] 714359001055 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 714359001056 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 714359001057 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 714359001058 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 714359001059 intersubunit interface [polypeptide binding]; other site 714359001060 active site 714359001061 Zn2+ binding site [ion binding]; other site 714359001062 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714359001063 ABC-ATPase subunit interface; other site 714359001064 dimer interface [polypeptide binding]; other site 714359001065 putative PBP binding regions; other site 714359001066 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714359001067 ABC-ATPase subunit interface; other site 714359001068 dimer interface [polypeptide binding]; other site 714359001069 putative PBP binding regions; other site 714359001070 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 714359001071 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 714359001072 putative ligand binding residues [chemical binding]; other site 714359001073 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 714359001074 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359001075 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 714359001076 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 714359001077 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359001078 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359001079 dimer interface [polypeptide binding]; other site 714359001080 phosphorylation site [posttranslational modification] 714359001081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359001082 ATP binding site [chemical binding]; other site 714359001083 Mg2+ binding site [ion binding]; other site 714359001084 G-X-G motif; other site 714359001085 Putative cyclase; Region: Cyclase; cl00814 714359001086 hypothetical protein; Provisional; Region: PRK06851 714359001087 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359001088 Walker A motif; other site 714359001089 ATP binding site [chemical binding]; other site 714359001090 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 714359001091 putative transposase OrfB; Reviewed; Region: PHA02517 714359001092 Integrase core domain; Region: rve; cl01316 714359001093 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 714359001094 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359001095 benzoate transport; Region: 2A0115; TIGR00895 714359001096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359001097 putative substrate translocation pore; other site 714359001098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359001099 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 714359001100 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 714359001101 [2Fe-2S] cluster binding site [ion binding]; other site 714359001102 Fatty acid desaturase; Region: FA_desaturase; pfam00487 714359001103 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 714359001104 putative di-iron ligands [ion binding]; other site 714359001105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359001106 dimer interface [polypeptide binding]; other site 714359001107 conserved gate region; other site 714359001108 putative PBP binding loops; other site 714359001109 ABC-ATPase subunit interface; other site 714359001110 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 714359001111 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714359001112 substrate binding pocket [chemical binding]; other site 714359001113 membrane-bound complex binding site; other site 714359001114 hinge residues; other site 714359001115 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 714359001116 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 714359001117 Walker A/P-loop; other site 714359001118 ATP binding site [chemical binding]; other site 714359001119 Q-loop/lid; other site 714359001120 ABC transporter signature motif; other site 714359001121 Walker B; other site 714359001122 D-loop; other site 714359001123 H-loop/switch region; other site 714359001124 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 714359001125 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 714359001126 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These transmembrane...; Region: TarH; cl00144 714359001127 Arginine repressor [Transcription]; Region: ArgR; COG1438 714359001128 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 714359001129 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 714359001130 Amidinotransferase; Region: Amidinotransf; cl12043 714359001131 ornithine carbamoyltransferase; Validated; Region: PRK02102 714359001132 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 714359001133 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359001134 Amino acid permease; Region: AA_permease; cl00524 714359001135 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 714359001136 putative substrate binding site [chemical binding]; other site 714359001137 homodimer interface [polypeptide binding]; other site 714359001138 nucleotide binding site [chemical binding]; other site 714359001139 nucleotide binding site [chemical binding]; other site 714359001140 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 714359001141 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 714359001142 ligand binding site [chemical binding]; other site 714359001143 flexible hinge region; other site 714359001144 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 714359001145 putative switch regulator; other site 714359001146 non-specific DNA interactions [nucleotide binding]; other site 714359001147 DNA binding site [nucleotide binding] 714359001148 sequence specific DNA binding site [nucleotide binding]; other site 714359001149 putative cAMP binding site [chemical binding]; other site 714359001150 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 714359001151 FAD binding domain; Region: FAD_binding_4; pfam01565 714359001152 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 714359001153 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 714359001154 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 714359001155 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 714359001156 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 714359001157 active site turn [active] 714359001158 phosphorylation site [posttranslational modification] 714359001159 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 714359001160 putative catalytic site [active] 714359001161 putative metal binding site [ion binding]; other site 714359001162 putative phosphate binding site [ion binding]; other site 714359001163 Predicted membrane protein [Function unknown]; Region: COG1511 714359001164 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 714359001165 Predicted membrane protein [Function unknown]; Region: COG1511 714359001166 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 714359001167 dinuclear metal binding motif [ion binding]; other site 714359001168 ABC-2 type transporter; Region: ABC2_membrane; cl11417 714359001169 DNA topoisomerase III; Provisional; Region: PRK07726 714359001170 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 714359001171 active site 714359001172 putative interdomain interaction site [polypeptide binding]; other site 714359001173 putative metal-binding site [ion binding]; other site 714359001174 putative nucleotide binding site [chemical binding]; other site 714359001175 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 714359001176 domain I; other site 714359001177 DNA binding groove [nucleotide binding] 714359001178 phosphate binding site [ion binding]; other site 714359001179 domain II; other site 714359001180 domain III; other site 714359001181 nucleotide binding site [chemical binding]; other site 714359001182 catalytic site [active] 714359001183 domain IV; other site 714359001184 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 714359001185 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 714359001186 substrate binding site [chemical binding]; other site 714359001187 multimerization interface [polypeptide binding]; other site 714359001188 ATP binding site [chemical binding]; other site 714359001189 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 714359001190 active site 714359001191 thiamine phosphate binding site [chemical binding]; other site 714359001192 pyrophosphate binding site [ion binding]; other site 714359001193 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 714359001194 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 714359001195 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 714359001196 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These transmembrane...; Region: TarH; cl00144 714359001197 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 714359001198 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359001199 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359001200 Phosphopantetheine attachment site; Region: PP-binding; cl09936 714359001201 thioester reductase domain; Region: Thioester-redct; TIGR01746 714359001202 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 714359001203 putative NAD(P) binding site [chemical binding]; other site 714359001204 active site 714359001205 putative substrate binding site [chemical binding]; other site 714359001206 Domain of unknown function DUF77; Region: DUF77; cl00307 714359001207 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359001208 dimer interface [polypeptide binding]; other site 714359001209 conserved gate region; other site 714359001210 putative PBP binding loops; other site 714359001211 ABC-ATPase subunit interface; other site 714359001212 NMT1/THI5 like; Region: NMT1; pfam09084 714359001213 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 714359001214 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 714359001215 Q-loop/lid; other site 714359001216 ABC transporter signature motif; other site 714359001217 Walker B; other site 714359001218 D-loop; other site 714359001219 H-loop/switch region; other site 714359001220 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359001221 H-loop/switch region; other site 714359001222 Glyco_18 domain; Region: Glyco_18; smart00636 714359001223 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 714359001224 active site 714359001225 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 714359001226 Cellulose binding domain; Region: CBM_2; cl02709 714359001227 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 714359001228 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 714359001229 catalytic residues [active] 714359001230 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359001231 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 714359001232 H+ Antiporter protein; Region: 2A0121; TIGR00900 714359001233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359001234 putative substrate translocation pore; other site 714359001235 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359001236 non-specific DNA binding site [nucleotide binding]; other site 714359001237 salt bridge; other site 714359001238 sequence-specific DNA binding site [nucleotide binding]; other site 714359001239 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 714359001240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359001241 putative substrate translocation pore; other site 714359001242 Sulfatase; Region: Sulfatase; cl10460 714359001243 prolyl-tRNA synthetase; Provisional; Region: PRK08661 714359001244 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_arch_euk; cd00778 714359001245 dimer interface [polypeptide binding]; other site 714359001246 motif 1; other site 714359001247 active site 714359001248 motif 2; other site 714359001249 motif 3; other site 714359001250 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 714359001251 anticodon binding site; other site 714359001252 zinc-binding site [ion binding]; other site 714359001253 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 714359001254 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 714359001255 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 714359001256 putative metal binding site [ion binding]; other site 714359001257 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 714359001258 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 714359001259 putative metal binding site [ion binding]; other site 714359001260 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 714359001261 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 714359001262 putative metal binding site [ion binding]; other site 714359001263 Integral membrane protein TerC family; Region: TerC; cl10468 714359001264 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 714359001265 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 714359001266 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 714359001267 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 714359001268 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 714359001269 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 714359001270 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 714359001271 Low molecular weight phosphatase family; Region: LMWPc; cd00115 714359001272 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 714359001273 active site 714359001274 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 714359001275 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 714359001276 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 714359001277 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 714359001278 EamA-like transporter family; Region: EamA; cl01037 714359001279 EamA-like transporter family; Region: EamA; cl01037 714359001280 YhhN-like protein; Region: YhhN; cl01505 714359001281 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 714359001282 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 714359001283 Catalytic site [active] 714359001284 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359001285 binding surface 714359001286 TPR motif; other site 714359001287 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 714359001288 EamA-like transporter family; Region: EamA; cl01037 714359001289 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 714359001290 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 714359001291 calcium/proton exchanger (cax); Region: cax; TIGR00378 714359001292 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 714359001293 Radical SAM superfamily; Region: Radical_SAM; pfam04055 714359001294 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359001295 FeS/SAM binding site; other site 714359001296 YfkB-like domain; Region: YfkB; pfam08756 714359001297 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 714359001298 Fumarase C-terminus; Region: Fumerase_C; cl00795 714359001299 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 714359001300 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 714359001301 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 714359001302 endonuclease III; Region: ENDO3c; smart00478 714359001303 minor groove reading motif; other site 714359001304 helix-hairpin-helix signature motif; other site 714359001305 substrate binding pocket [chemical binding]; other site 714359001306 active site 714359001307 TRAM domain; Region: TRAM; cl01282 714359001308 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 714359001309 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359001310 S-adenosylmethionine binding site [chemical binding]; other site 714359001311 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 714359001312 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 714359001313 dimerization interface 3.5A [polypeptide binding]; other site 714359001314 active site 714359001315 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 714359001316 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359001317 Walker A motif; other site 714359001318 ATP binding site [chemical binding]; other site 714359001319 Walker B motif; other site 714359001320 arginine finger; other site 714359001321 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359001322 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 714359001323 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 714359001324 Amino acid permease; Region: AA_permease; cl00524 714359001325 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 714359001326 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 714359001327 metal binding site [ion binding]; metal-binding site 714359001328 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359001329 non-specific DNA binding site [nucleotide binding]; other site 714359001330 salt bridge; other site 714359001331 sequence-specific DNA binding site [nucleotide binding]; other site 714359001332 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 714359001333 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 714359001334 Glutaminase; Region: Glutaminase; cl00907 714359001335 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 714359001336 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 714359001337 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 714359001338 active site turn [active] 714359001339 phosphorylation site [posttranslational modification] 714359001340 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359001341 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 714359001342 active site 714359001343 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 714359001344 active site 714359001345 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 714359001346 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359001347 NAD(P) binding site [chemical binding]; other site 714359001348 active site 714359001349 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 714359001350 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359001351 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359001352 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 714359001353 NAD(P) binding site [chemical binding]; other site 714359001354 active site 714359001355 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 714359001356 active site 714359001357 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 714359001358 active site 714359001359 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 714359001360 Pyruvate formate lyase 1; Region: PFL1; cd01678 714359001361 coenzyme A binding site [chemical binding]; other site 714359001362 active site 714359001363 catalytic residues [active] 714359001364 glycine loop; other site 714359001365 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 714359001366 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359001367 FeS/SAM binding site; other site 714359001368 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 714359001369 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 714359001370 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714359001371 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 714359001372 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 714359001373 active site 714359001374 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 714359001375 TIGR01777 family protein; Region: yfcH 714359001376 putative NAD(P) binding site [chemical binding]; other site 714359001377 putative active site [active] 714359001378 RecX family; Region: RecX; cl00936 714359001379 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 714359001380 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 714359001381 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 714359001382 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 714359001383 minor groove reading motif; other site 714359001384 helix-hairpin-helix signature motif; other site 714359001385 substrate binding pocket [chemical binding]; other site 714359001386 active site 714359001387 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 714359001388 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 714359001389 DNA binding and oxoG recognition site [nucleotide binding] 714359001390 Protein of unknown function (DUF402); Region: DUF402; cl00979 714359001391 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 714359001392 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 714359001393 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 714359001394 Walker A/P-loop; other site 714359001395 ATP binding site [chemical binding]; other site 714359001396 Q-loop/lid; other site 714359001397 ABC transporter signature motif; other site 714359001398 Walker B; other site 714359001399 D-loop; other site 714359001400 H-loop/switch region; other site 714359001401 Predicted membrane protein [Function unknown]; Region: COG4129 714359001402 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 714359001403 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 714359001404 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 714359001405 active site 714359001406 dimer interface [polypeptide binding]; other site 714359001407 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 714359001408 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 714359001409 active site 714359001410 FMN binding site [chemical binding]; other site 714359001411 substrate binding site [chemical binding]; other site 714359001412 3Fe-4S cluster binding site [ion binding]; other site 714359001413 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 714359001414 domain_subunit interface; other site 714359001415 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 714359001416 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 714359001417 inhibitor-cofactor binding pocket; inhibition site 714359001418 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359001419 catalytic residue [active] 714359001420 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 714359001421 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359001422 Walker A/P-loop; other site 714359001423 ATP binding site [chemical binding]; other site 714359001424 Q-loop/lid; other site 714359001425 ABC transporter signature motif; other site 714359001426 Walker B; other site 714359001427 D-loop; other site 714359001428 H-loop/switch region; other site 714359001429 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 714359001430 Protein of unknown function (DUF990); Region: DUF990; cl01496 714359001431 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 714359001432 Protein of unknown function (DUF990); Region: DUF990; cl01496 714359001433 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 714359001434 catalytic triad [active] 714359001435 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 714359001436 metal binding site 2 [ion binding]; metal-binding site 714359001437 putative DNA binding helix; other site 714359001438 metal binding site 1 [ion binding]; metal-binding site 714359001439 dimer interface [polypeptide binding]; other site 714359001440 structural Zn2+ binding site [ion binding]; other site 714359001441 Protein of unknown function (DUF2614); Region: DUF2614; cl07936 714359001442 Domain of unknown function DUF28; Region: DUF28; cl00361 714359001443 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 714359001444 nudix motif; other site 714359001445 Transglycosylase; Region: Transgly; cl07896 714359001446 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 714359001447 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 714359001448 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 714359001449 4Fe-4S binding domain; Region: Fer4; cl02805 714359001450 stage II sporulation protein E; Region: spore_II_E; TIGR02865 714359001451 NlpC/P60 family; Region: NLPC_P60; cl11438 714359001452 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 714359001453 PAS fold; Region: PAS_4; pfam08448 714359001454 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714359001455 putative active site [active] 714359001456 heme pocket [chemical binding]; other site 714359001457 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714359001458 metal binding site [ion binding]; metal-binding site 714359001459 active site 714359001460 I-site; other site 714359001461 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 714359001462 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 714359001463 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359001464 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 714359001465 Uncharacterized conserved protein [Function unknown]; Region: COG2718 714359001466 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 714359001467 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 714359001468 heme-binding site [chemical binding]; other site 714359001469 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 714359001470 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 714359001471 Leucine-rich repeats; other site 714359001472 Substrate binding site [chemical binding]; other site 714359001473 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 714359001474 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 714359001475 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359001476 Coenzyme A binding pocket [chemical binding]; other site 714359001477 BCCT family transporter; Region: BCCT; cl00569 714359001478 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 714359001479 Collagenase; Region: Peptidase_M9; pfam01752 714359001480 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 714359001481 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 714359001482 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 714359001483 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 714359001484 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These transmembrane...; Region: TarH; cl00144 714359001485 Cache domain; Region: Cache_1; pfam02743 714359001486 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 714359001487 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359001488 dimerization interface [polypeptide binding]; other site 714359001489 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 714359001490 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These transmembrane...; Region: TarH; cl00144 714359001491 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 714359001492 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 714359001493 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359001494 ATP binding site [chemical binding]; other site 714359001495 Mg2+ binding site [ion binding]; other site 714359001496 G-X-G motif; other site 714359001497 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 714359001498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359001499 active site 714359001500 phosphorylation site [posttranslational modification] 714359001501 intermolecular recognition site; other site 714359001502 dimerization interface [polypeptide binding]; other site 714359001503 Na+/H+ antiporter family; Region: Na_H_antiporter; cl15356 714359001504 Citrate transporter; Region: CitMHS; pfam03600 714359001505 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 714359001506 NosL; Region: NosL; cl01769 714359001507 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 714359001508 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 714359001509 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 714359001510 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 714359001511 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 714359001512 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 714359001513 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359001514 Walker A/P-loop; other site 714359001515 ATP binding site [chemical binding]; other site 714359001516 Q-loop/lid; other site 714359001517 ABC transporter signature motif; other site 714359001518 Walker B; other site 714359001519 D-loop; other site 714359001520 H-loop/switch region; other site 714359001521 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 714359001522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359001523 dimer interface [polypeptide binding]; other site 714359001524 conserved gate region; other site 714359001525 putative PBP binding loops; other site 714359001526 ABC-ATPase subunit interface; other site 714359001527 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 714359001528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 714359001529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359001530 dimer interface [polypeptide binding]; other site 714359001531 conserved gate region; other site 714359001532 putative PBP binding loops; other site 714359001533 ABC-ATPase subunit interface; other site 714359001534 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 714359001535 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 714359001536 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 714359001537 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 714359001538 active site 714359001539 metal binding site [ion binding]; metal-binding site 714359001540 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359001541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359001542 active site 714359001543 phosphorylation site [posttranslational modification] 714359001544 intermolecular recognition site; other site 714359001545 dimerization interface [polypeptide binding]; other site 714359001546 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359001547 DNA binding site [nucleotide binding] 714359001548 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359001549 dimer interface [polypeptide binding]; other site 714359001550 phosphorylation site [posttranslational modification] 714359001551 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359001552 ATP binding site [chemical binding]; other site 714359001553 Mg2+ binding site [ion binding]; other site 714359001554 G-X-G motif; other site 714359001555 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 714359001556 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 714359001557 putative active site [active] 714359001558 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These transmembrane...; Region: TarH; cl00144 714359001559 Cache domain; Region: Cache_1; pfam02743 714359001560 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 714359001561 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359001562 dimerization interface [polypeptide binding]; other site 714359001563 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 714359001564 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These transmembrane...; Region: TarH; cl00144 714359001565 sensory histidine kinase DcuS; Provisional; Region: PRK11086 714359001566 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359001567 ATP binding site [chemical binding]; other site 714359001568 Mg2+ binding site [ion binding]; other site 714359001569 G-X-G motif; other site 714359001570 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 714359001571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359001572 active site 714359001573 phosphorylation site [posttranslational modification] 714359001574 intermolecular recognition site; other site 714359001575 dimerization interface [polypeptide binding]; other site 714359001576 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 714359001577 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 714359001578 Malic enzyme, N-terminal domain; Region: malic; pfam00390 714359001579 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 714359001580 putative NAD(P) binding site [chemical binding]; other site 714359001581 EamA-like transporter family; Region: EamA; cl01037 714359001582 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 714359001583 EamA-like transporter family; Region: EamA; cl01037 714359001584 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 714359001585 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359001586 DNA-binding site [nucleotide binding]; DNA binding site 714359001587 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714359001588 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359001589 homodimer interface [polypeptide binding]; other site 714359001590 catalytic residue [active] 714359001591 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 714359001592 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359001593 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359001594 Coenzyme A binding pocket [chemical binding]; other site 714359001595 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 714359001596 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359001597 dimer interface [polypeptide binding]; other site 714359001598 phosphorylation site [posttranslational modification] 714359001599 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359001600 ATP binding site [chemical binding]; other site 714359001601 Mg2+ binding site [ion binding]; other site 714359001602 G-X-G motif; other site 714359001603 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359001604 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359001605 active site 714359001606 phosphorylation site [posttranslational modification] 714359001607 intermolecular recognition site; other site 714359001608 dimerization interface [polypeptide binding]; other site 714359001609 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359001610 DNA binding site [nucleotide binding] 714359001611 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714359001612 Arrestin_N terminal like; Region: LDB19; pfam13002 714359001613 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359001614 Coenzyme A binding pocket [chemical binding]; other site 714359001615 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 714359001616 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 714359001617 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 714359001618 [4Fe-4S] binding site [ion binding]; other site 714359001619 molybdopterin cofactor binding site; other site 714359001620 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 714359001621 molybdopterin cofactor binding site; other site 714359001622 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 714359001623 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 714359001624 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 714359001625 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 714359001626 putative active site [active] 714359001627 catalytic site [active] 714359001628 putative metal binding site [ion binding]; other site 714359001629 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 714359001630 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 714359001631 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359001632 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 714359001633 Amino acid permease; Region: AA_permease; cl00524 714359001634 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359001635 dimerization interface [polypeptide binding]; other site 714359001636 putative DNA binding site [nucleotide binding]; other site 714359001637 putative Zn2+ binding site [ion binding]; other site 714359001638 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 714359001639 metal-binding site [ion binding] 714359001640 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 714359001641 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 714359001642 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 714359001643 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 714359001644 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 714359001645 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 714359001646 active site 714359001647 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359001648 non-specific DNA binding site [nucleotide binding]; other site 714359001649 salt bridge; other site 714359001650 sequence-specific DNA binding site [nucleotide binding]; other site 714359001651 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 714359001652 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 714359001653 Peptidase propeptide and YPEB domain; Region: PepSY; cl15480 714359001654 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 714359001655 active site 714359001656 Zn binding site [ion binding]; other site 714359001657 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 714359001658 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 714359001659 VanW like protein; Region: VanW; pfam04294 714359001660 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 714359001661 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 714359001662 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 714359001663 Nucleoside recognition; Region: Gate; cl00486 714359001664 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 714359001665 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 714359001666 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359001667 putative metal binding site [ion binding]; other site 714359001668 FOG: CBS domain [General function prediction only]; Region: COG0517 714359001669 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 714359001670 Transporter associated domain; Region: CorC_HlyC; cl08393 714359001671 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 714359001672 Aspartase; Region: Aspartase; cd01357 714359001673 active sites [active] 714359001674 tetramer interface [polypeptide binding]; other site 714359001675 glycolate transporter; Provisional; Region: PRK09695 714359001676 L-lactate permease; Region: Lactate_perm; cl00701 714359001677 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359001678 putative DNA binding site [nucleotide binding]; other site 714359001679 putative Zn2+ binding site [ion binding]; other site 714359001680 Small acid-soluble spore protein H family; Region: SspH; cl06949 714359001681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 714359001682 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 714359001683 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 714359001684 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 714359001685 siderophore binding site; other site 714359001686 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714359001687 ABC-ATPase subunit interface; other site 714359001688 dimer interface [polypeptide binding]; other site 714359001689 putative PBP binding regions; other site 714359001690 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 714359001691 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714359001692 ABC-ATPase subunit interface; other site 714359001693 dimer interface [polypeptide binding]; other site 714359001694 putative PBP binding regions; other site 714359001695 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 714359001696 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 714359001697 Walker A/P-loop; other site 714359001698 ATP binding site [chemical binding]; other site 714359001699 Q-loop/lid; other site 714359001700 ABC transporter signature motif; other site 714359001701 Walker B; other site 714359001702 D-loop; other site 714359001703 H-loop/switch region; other site 714359001704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359001705 S-adenosylmethionine binding site [chemical binding]; other site 714359001706 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 714359001707 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 714359001708 substrate-cofactor binding pocket; other site 714359001709 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359001710 catalytic residue [active] 714359001711 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 714359001712 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 714359001713 NAD binding site [chemical binding]; other site 714359001714 homodimer interface [polypeptide binding]; other site 714359001715 active site 714359001716 putative substrate binding site [chemical binding]; other site 714359001717 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 714359001718 nudix motif; other site 714359001719 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 714359001720 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 714359001721 metal ion-dependent adhesion site (MIDAS); other site 714359001722 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359001723 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 714359001724 Walker A motif; other site 714359001725 ATP binding site [chemical binding]; other site 714359001726 Walker B motif; other site 714359001727 arginine finger; other site 714359001728 cardiolipin synthetase; Reviewed; Region: PRK12452 714359001729 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 714359001730 putative active site [active] 714359001731 catalytic site [active] 714359001732 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 714359001733 putative active site [active] 714359001734 catalytic site [active] 714359001735 PAS domain S-box; Region: sensory_box; TIGR00229 714359001736 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714359001737 putative active site [active] 714359001738 heme pocket [chemical binding]; other site 714359001739 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714359001740 metal binding site [ion binding]; metal-binding site 714359001741 active site 714359001742 I-site; other site 714359001743 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 714359001744 Amino acid permease; Region: AA_permease; cl00524 714359001745 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359001746 DNA-binding site [nucleotide binding]; DNA binding site 714359001747 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 714359001748 UTRA domain; Region: UTRA; cl01230 714359001749 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 714359001750 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 714359001751 active site turn [active] 714359001752 phosphorylation site [posttranslational modification] 714359001753 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 714359001754 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 714359001755 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 714359001756 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 714359001757 Amino acid permease; Region: AA_permease; cl00524 714359001758 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 714359001759 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 714359001760 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 714359001761 active site 714359001762 ATP binding site [chemical binding]; other site 714359001763 substrate binding site [chemical binding]; other site 714359001764 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 714359001765 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 714359001766 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 714359001767 Walker A/P-loop; other site 714359001768 ATP binding site [chemical binding]; other site 714359001769 Q-loop/lid; other site 714359001770 ABC transporter signature motif; other site 714359001771 Walker B; other site 714359001772 D-loop; other site 714359001773 H-loop/switch region; other site 714359001774 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 714359001775 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714359001776 substrate binding pocket [chemical binding]; other site 714359001777 membrane-bound complex binding site; other site 714359001778 hinge residues; other site 714359001779 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 714359001780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359001781 dimer interface [polypeptide binding]; other site 714359001782 conserved gate region; other site 714359001783 putative PBP binding loops; other site 714359001784 ABC-ATPase subunit interface; other site 714359001785 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359001786 dimer interface [polypeptide binding]; other site 714359001787 conserved gate region; other site 714359001788 putative PBP binding loops; other site 714359001789 ABC-ATPase subunit interface; other site 714359001790 Amino acid permease; Region: AA_permease; cl00524 714359001791 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 714359001792 OsmC-like protein; Region: OsmC; cl00767 714359001793 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 714359001794 nucleotide binding site/active site [active] 714359001795 HIT family signature motif; other site 714359001796 catalytic residue [active] 714359001797 Predicted transcriptional regulator [Transcription]; Region: COG2378 714359001798 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359001799 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 714359001800 folate binding site [chemical binding]; other site 714359001801 NADP+ binding site [chemical binding]; other site 714359001802 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 714359001803 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359001804 dimerization interface [polypeptide binding]; other site 714359001805 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359001806 dimer interface [polypeptide binding]; other site 714359001807 phosphorylation site [posttranslational modification] 714359001808 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359001809 ATP binding site [chemical binding]; other site 714359001810 Mg2+ binding site [ion binding]; other site 714359001811 G-X-G motif; other site 714359001812 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359001813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359001814 active site 714359001815 phosphorylation site [posttranslational modification] 714359001816 intermolecular recognition site; other site 714359001817 dimerization interface [polypeptide binding]; other site 714359001818 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359001819 DNA binding site [nucleotide binding] 714359001820 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 714359001821 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 714359001822 Permease family; Region: Xan_ur_permease; cl00967 714359001823 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 714359001824 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 714359001825 Ligand Binding Site [chemical binding]; other site 714359001826 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 714359001827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359001828 putative substrate translocation pore; other site 714359001829 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359001830 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 714359001831 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359001832 putative substrate translocation pore; other site 714359001833 Transcriptional regulators [Transcription]; Region: PurR; COG1609 714359001834 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 714359001835 DNA binding site [nucleotide binding] 714359001836 domain linker motif; other site 714359001837 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 714359001838 dimerization interface [polypeptide binding]; other site 714359001839 ligand binding site [chemical binding]; other site 714359001840 sodium binding site [ion binding]; other site 714359001841 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 714359001842 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 714359001843 substrate binding site [chemical binding]; other site 714359001844 dimer interface [polypeptide binding]; other site 714359001845 ATP binding site [chemical binding]; other site 714359001846 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 714359001847 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 714359001848 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 714359001849 Walker A/P-loop; other site 714359001850 ATP binding site [chemical binding]; other site 714359001851 Q-loop/lid; other site 714359001852 ABC transporter signature motif; other site 714359001853 Walker B; other site 714359001854 D-loop; other site 714359001855 H-loop/switch region; other site 714359001856 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 714359001857 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 714359001858 TM-ABC transporter signature motif; other site 714359001859 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 714359001860 ligand binding site [chemical binding]; other site 714359001861 dimerization interface [polypeptide binding]; other site 714359001862 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 714359001863 active site 714359001864 intersubunit interactions; other site 714359001865 catalytic residue [active] 714359001866 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 714359001867 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 714359001868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359001869 putative substrate translocation pore; other site 714359001870 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 714359001871 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 714359001872 putative NAD(P) binding site [chemical binding]; other site 714359001873 catalytic Zn binding site [ion binding]; other site 714359001874 Ion channel; Region: Ion_trans_2; cl11596 714359001875 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; cl03005 714359001876 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 714359001877 putative catalytic site [active] 714359001878 metal binding site A [ion binding]; metal-binding site 714359001879 phosphate binding site [ion binding]; other site 714359001880 metal binding site C [ion binding]; metal-binding site 714359001881 metal binding site B [ion binding]; metal-binding site 714359001882 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 714359001883 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 714359001884 dimer interface [polypeptide binding]; other site 714359001885 active site 714359001886 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 714359001887 substrate binding site [chemical binding]; other site 714359001888 catalytic residue [active] 714359001889 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 714359001890 FAD binding domain; Region: FAD_binding_4; pfam01565 714359001891 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 714359001892 VanZ like family; Region: VanZ; cl01971 714359001893 RDD family; Region: RDD; cl00746 714359001894 Bacitracin resistance protein BacA; Region: BacA; cl00858 714359001895 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 714359001896 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These transmembrane...; Region: TarH; cl00144 714359001897 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 714359001898 3D domain; Region: 3D; cl01439 714359001899 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359001900 non-specific DNA binding site [nucleotide binding]; other site 714359001901 salt bridge; other site 714359001902 sequence-specific DNA binding site [nucleotide binding]; other site 714359001903 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 714359001904 active site 714359001905 catalytic site [active] 714359001906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 714359001907 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 714359001908 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 714359001909 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 714359001910 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 714359001911 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 714359001912 Amino acid permease; Region: AA_permease; cl00524 714359001913 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 714359001914 Permease family; Region: Xan_ur_permease; cl00967 714359001915 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359001916 non-specific DNA binding site [nucleotide binding]; other site 714359001917 salt bridge; other site 714359001918 sequence-specific DNA binding site [nucleotide binding]; other site 714359001919 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359001920 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 714359001921 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 714359001922 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 714359001923 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359001924 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 714359001925 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 714359001926 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 714359001927 Subunit I/III interface [polypeptide binding]; other site 714359001928 Subunit III/IV interface [polypeptide binding]; other site 714359001929 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 714359001930 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 714359001931 D-pathway; other site 714359001932 Putative ubiquinol binding site [chemical binding]; other site 714359001933 Low-spin heme (heme b) binding site [chemical binding]; other site 714359001934 Putative water exit pathway; other site 714359001935 Binuclear center (heme o3/CuB) [ion binding]; other site 714359001936 K-pathway; other site 714359001937 Putative proton exit pathway; other site 714359001938 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 714359001939 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 714359001940 Amino acid permease; Region: AA_permease; cl00524 714359001941 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 714359001942 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 714359001943 putative active site [active] 714359001944 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 714359001945 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 714359001946 metal binding site [ion binding]; metal-binding site 714359001947 dimer interface [polypeptide binding]; other site 714359001948 Sodium:solute symporter family; Region: SSF; cl00456 714359001949 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 714359001950 Amino acid permease; Region: AA_permease; cl00524 714359001951 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 714359001952 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 714359001953 Nucleoside recognition; Region: Gate; cl00486 714359001954 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 714359001955 Nucleoside recognition; Region: Gate; cl00486 714359001956 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 714359001957 Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this...; Region: FeoB; cd01879 714359001958 G1 box; other site 714359001959 GTP/Mg2+ binding site [chemical binding]; other site 714359001960 Switch I region; other site 714359001961 G2 box; other site 714359001962 G3 box; other site 714359001963 Switch II region; other site 714359001964 G4 box; other site 714359001965 G5 box; other site 714359001966 FeoA domain; Region: FeoA; cl00838 714359001967 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 714359001968 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 714359001969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359001970 dimer interface [polypeptide binding]; other site 714359001971 conserved gate region; other site 714359001972 putative PBP binding loops; other site 714359001973 ABC-ATPase subunit interface; other site 714359001974 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 714359001975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359001976 dimer interface [polypeptide binding]; other site 714359001977 conserved gate region; other site 714359001978 putative PBP binding loops; other site 714359001979 ABC-ATPase subunit interface; other site 714359001980 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 714359001981 Protein export membrane protein; Region: SecD_SecF; cl14618 714359001982 FOG: CBS domain [General function prediction only]; Region: COG0517 714359001983 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 714359001984 Bacterial SH3 domain; Region: SH3_3; cl02551 714359001985 Bacterial SH3 domain; Region: SH3_3; cl02551 714359001986 Bacterial SH3 domain; Region: SH3_3; cl02551 714359001987 Peptidase family M23; Region: Peptidase_M23; pfam01551 714359001988 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 714359001989 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 714359001990 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 714359001991 Walker A/P-loop; other site 714359001992 ATP binding site [chemical binding]; other site 714359001993 Q-loop/lid; other site 714359001994 ABC transporter signature motif; other site 714359001995 Walker B; other site 714359001996 D-loop; other site 714359001997 H-loop/switch region; other site 714359001998 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 714359001999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 714359002000 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 714359002001 NMT1/THI5 like; Region: NMT1; pfam09084 714359002002 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 714359002003 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 714359002004 thiamine phosphate binding site [chemical binding]; other site 714359002005 active site 714359002006 pyrophosphate binding site [ion binding]; other site 714359002007 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 714359002008 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359002009 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 714359002010 thiS-thiF/thiG interaction site; other site 714359002011 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 714359002012 ThiS interaction site; other site 714359002013 putative active site [active] 714359002014 tetramer interface [polypeptide binding]; other site 714359002015 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 714359002016 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 714359002017 ATP binding site [chemical binding]; other site 714359002018 substrate interface [chemical binding]; other site 714359002019 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 714359002020 dimer interface [polypeptide binding]; other site 714359002021 substrate binding site [chemical binding]; other site 714359002022 ATP binding site [chemical binding]; other site 714359002023 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 714359002024 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 714359002025 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 714359002026 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 714359002027 K+-transporting ATPase, c chain; Region: KdpC; cl00944 714359002028 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 714359002029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359002030 putative substrate translocation pore; other site 714359002031 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359002032 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 714359002033 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 714359002034 active site 714359002035 nucleophile elbow; other site 714359002036 Permease family; Region: Xan_ur_permease; cl00967 714359002037 short chain dehydrogenase; Provisional; Region: PRK06701 714359002038 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 714359002039 NAD binding site [chemical binding]; other site 714359002040 metal binding site [ion binding]; metal-binding site 714359002041 active site 714359002042 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 714359002043 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 714359002044 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 714359002045 putative substrate binding site [chemical binding]; other site 714359002046 putative ATP binding site [chemical binding]; other site 714359002047 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 714359002048 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 714359002049 substrate binding [chemical binding]; other site 714359002050 active site 714359002051 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 714359002052 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 714359002053 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 714359002054 active site turn [active] 714359002055 phosphorylation site [posttranslational modification] 714359002056 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 714359002057 Transcriptional regulators [Transcription]; Region: PurR; COG1609 714359002058 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 714359002059 DNA binding site [nucleotide binding] 714359002060 domain linker motif; other site 714359002061 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 714359002062 dimerization interface [polypeptide binding]; other site 714359002063 ligand binding site [chemical binding]; other site 714359002064 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 714359002065 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 714359002066 catalytic residues [active] 714359002067 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 714359002068 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 714359002069 Amino acid permease; Region: AA_permease; cl00524 714359002070 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 714359002071 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 714359002072 SLBB-domain like (DUF1017); Region: DUF1017; pfam06251 714359002073 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 714359002074 putative FMN binding site [chemical binding]; other site 714359002075 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 714359002076 SpoVR like protein; Region: SpoVR; pfam04293 714359002077 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 714359002078 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 714359002079 Protein of unknown function, DUF2606; Region: DUF2606; pfam10794 714359002080 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 714359002081 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359002082 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 714359002083 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 714359002084 active site residue [active] 714359002085 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 714359002086 putative homotetramer interface [polypeptide binding]; other site 714359002087 putative homodimer interface [polypeptide binding]; other site 714359002088 putative metal binding site [ion binding]; other site 714359002089 putative homodimer-homodimer interface [polypeptide binding]; other site 714359002090 putative allosteric switch controlling residues; other site 714359002091 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 714359002092 CPxP motif; other site 714359002093 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 714359002094 active site residue [active] 714359002095 Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with rhodanese-like domains found N-terminal of the metallo-beta-lactamase domain; Region: RHOD_Lact_B; cd01523 714359002096 active site residue [active] 714359002097 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 714359002098 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 714359002099 CPxP motif; other site 714359002100 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 714359002101 active site residue [active] 714359002102 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 714359002103 active site residue [active] 714359002104 DsrE/DsrF-like family; Region: DrsE; cl00672 714359002105 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 714359002106 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 714359002107 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 714359002108 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 714359002109 NADP binding site [chemical binding]; other site 714359002110 dimer interface [polypeptide binding]; other site 714359002111 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 714359002112 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 714359002113 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 714359002114 PhoU domain; Region: PhoU; pfam01895 714359002115 PhoU domain; Region: PhoU; pfam01895 714359002116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359002117 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359002118 putative substrate translocation pore; other site 714359002119 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 714359002120 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359002121 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 714359002122 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359002123 PRD domain; Region: PRD; cl15445 714359002124 PRD domain; Region: PRD; cl15445 714359002125 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 714359002126 P-loop; other site 714359002127 active site 714359002128 phosphorylation site [posttranslational modification] 714359002129 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 714359002130 active site 714359002131 phosphorylation site [posttranslational modification] 714359002132 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 714359002133 active site 714359002134 methionine cluster; other site 714359002135 phosphorylation site [posttranslational modification] 714359002136 metal binding site [ion binding]; metal-binding site 714359002137 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 714359002138 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 714359002139 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 714359002140 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 714359002141 Bacterial SH3 domain; Region: SH3_3; cl02551 714359002142 Bacterial SH3 domain; Region: SH3_3; cl02551 714359002143 3D domain; Region: 3D; cl01439 714359002144 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 714359002145 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 714359002146 FtsX-like permease family; Region: FtsX; pfam02687 714359002147 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 714359002148 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 714359002149 Walker A/P-loop; other site 714359002150 ATP binding site [chemical binding]; other site 714359002151 Q-loop/lid; other site 714359002152 ABC transporter signature motif; other site 714359002153 Walker B; other site 714359002154 D-loop; other site 714359002155 H-loop/switch region; other site 714359002156 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 714359002157 B-cell receptor-associated protein 31-like; Region: Bap31; cl02219 714359002158 Predicted integral membrane protein [Function unknown]; Region: COG5522; cl02331 714359002159 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 714359002160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 714359002161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359002162 dimer interface [polypeptide binding]; other site 714359002163 conserved gate region; other site 714359002164 ABC-ATPase subunit interface; other site 714359002165 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 714359002166 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 714359002167 dimanganese center [ion binding]; other site 714359002168 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 714359002169 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 714359002170 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 714359002171 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 714359002172 putative DNA binding site [nucleotide binding]; other site 714359002173 putative homodimer interface [polypeptide binding]; other site 714359002174 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 714359002175 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 714359002176 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 714359002177 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 714359002178 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 714359002179 active site 714359002180 metal binding site [ion binding]; metal-binding site 714359002181 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 714359002182 Interdomain contacts; other site 714359002183 Cytokine receptor motif; other site 714359002184 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 714359002185 Amino acid permease; Region: AA_permease; cl00524 714359002186 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 714359002187 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 714359002188 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 714359002189 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 714359002190 putative active site [active] 714359002191 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 714359002192 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 714359002193 putative active site [active] 714359002194 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 714359002195 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 714359002196 active site turn [active] 714359002197 phosphorylation site [posttranslational modification] 714359002198 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 714359002199 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 714359002200 DoxX; Region: DoxX; cl00976 714359002201 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 714359002202 hypothetical protein; Provisional; Region: PRK06770 714359002203 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 714359002204 EamA-like transporter family; Region: EamA; cl01037 714359002205 EamA-like transporter family; Region: EamA; cl01037 714359002206 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359002207 bifunctional argininosuccinate lyase/N-acetylglutamate synthase; Provisional; Region: PRK12308 714359002208 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359002209 Coenzyme A binding pocket [chemical binding]; other site 714359002210 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 714359002211 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 714359002212 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359002213 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359002214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359002215 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359002216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359002217 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359002218 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 714359002219 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 714359002220 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 714359002221 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 714359002222 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 714359002223 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359002224 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359002225 putative substrate translocation pore; other site 714359002226 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 714359002227 proposed catalytic triad [active] 714359002228 conserved cys residue [active] 714359002229 hydroperoxidase II; Provisional; Region: katE; PRK11249 714359002230 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 714359002231 tetramer interface [polypeptide binding]; other site 714359002232 heme binding pocket [chemical binding]; other site 714359002233 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 714359002234 domain interactions; other site 714359002235 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 714359002236 Amino acid permease; Region: AA_permease; cl00524 714359002237 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 714359002238 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 714359002239 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 714359002240 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 714359002241 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 714359002242 tetrameric interface [polypeptide binding]; other site 714359002243 activator binding site; other site 714359002244 NADP binding site [chemical binding]; other site 714359002245 substrate binding site [chemical binding]; other site 714359002246 catalytic residues [active] 714359002247 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 714359002248 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 714359002249 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359002250 Walker A/P-loop; other site 714359002251 ATP binding site [chemical binding]; other site 714359002252 Q-loop/lid; other site 714359002253 ABC transporter signature motif; other site 714359002254 Walker B; other site 714359002255 D-loop; other site 714359002256 H-loop/switch region; other site 714359002257 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 714359002258 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 714359002259 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 714359002260 Walker A/P-loop; other site 714359002261 ATP binding site [chemical binding]; other site 714359002262 Q-loop/lid; other site 714359002263 ABC transporter signature motif; other site 714359002264 Walker B; other site 714359002265 D-loop; other site 714359002266 H-loop/switch region; other site 714359002267 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 714359002268 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714359002269 substrate binding pocket [chemical binding]; other site 714359002270 membrane-bound complex binding site; other site 714359002271 hinge residues; other site 714359002272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359002273 dimer interface [polypeptide binding]; other site 714359002274 conserved gate region; other site 714359002275 putative PBP binding loops; other site 714359002276 ABC-ATPase subunit interface; other site 714359002277 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 714359002278 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 714359002279 Walker A/P-loop; other site 714359002280 ATP binding site [chemical binding]; other site 714359002281 Q-loop/lid; other site 714359002282 ABC transporter signature motif; other site 714359002283 Walker B; other site 714359002284 D-loop; other site 714359002285 H-loop/switch region; other site 714359002286 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 714359002287 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 714359002288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 714359002289 Protein of unknown function (DUF964); Region: DUF964; cl01483 714359002290 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 714359002291 Histidine kinase; Region: HisKA_3; pfam07730 714359002292 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 714359002293 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 714359002294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359002295 active site 714359002296 phosphorylation site [posttranslational modification] 714359002297 intermolecular recognition site; other site 714359002298 dimerization interface [polypeptide binding]; other site 714359002299 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714359002300 DNA binding residues [nucleotide binding] 714359002301 dimerization interface [polypeptide binding]; other site 714359002302 acetolactate synthase; Reviewed; Region: PRK08617 714359002303 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 714359002304 PYR/PP interface [polypeptide binding]; other site 714359002305 dimer interface [polypeptide binding]; other site 714359002306 TPP binding site [chemical binding]; other site 714359002307 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 714359002308 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 714359002309 TPP-binding site [chemical binding]; other site 714359002310 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 714359002311 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 714359002312 active site 714359002313 DNA binding site [nucleotide binding] 714359002314 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 714359002315 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 714359002316 active site 714359002317 motif I; other site 714359002318 motif II; other site 714359002319 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 714359002320 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359002321 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359002322 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359002323 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359002324 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359002325 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359002326 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359002327 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359002328 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359002329 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 714359002330 amidase catalytic site [active] 714359002331 Zn binding residues [ion binding]; other site 714359002332 substrate binding site [chemical binding]; other site 714359002333 S-layer homology domain; Region: SLH; pfam00395 714359002334 S-layer homology domain; Region: SLH; pfam00395 714359002335 S-layer homology domain; Region: SLH; pfam00395 714359002336 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 714359002337 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359002338 FeS/SAM binding site; other site 714359002339 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 714359002340 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359002341 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359002342 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 714359002343 Permease family; Region: Xan_ur_permease; cl00967 714359002344 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 714359002345 stage V sporulation protein B; Region: spore_V_B; TIGR02900 714359002346 MatE; Region: MatE; cl10513 714359002347 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; cl09156 714359002348 S-layer homology domain; Region: SLH; pfam00395 714359002349 S-layer homology domain; Region: SLH; pfam00395 714359002350 S-layer homology domain; Region: SLH; pfam00395 714359002351 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 714359002352 enoyl-CoA hydratase; Provisional; Region: PRK07659 714359002353 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 714359002354 substrate binding site [chemical binding]; other site 714359002355 oxyanion hole (OAH) forming residues; other site 714359002356 trimer interface [polypeptide binding]; other site 714359002357 Uncharacterized conserved protein [Function unknown]; Region: COG4997 714359002358 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 714359002359 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 714359002360 putative oligomer interface [polypeptide binding]; other site 714359002361 putative active site [active] 714359002362 metal binding site [ion binding]; metal-binding site 714359002363 S-layer homology domain; Region: SLH; pfam00395 714359002364 S-layer homology domain; Region: SLH; pfam00395 714359002365 S-layer homology domain; Region: SLH; pfam00395 714359002366 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 714359002367 active site 714359002368 metal binding site [ion binding]; metal-binding site 714359002369 Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041 714359002370 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359002371 S-adenosylmethionine binding site [chemical binding]; other site 714359002372 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 714359002373 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 714359002374 ornithine cyclodeaminase; Validated; Region: PRK08618 714359002375 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 714359002376 NAD(P) binding site [chemical binding]; other site 714359002377 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 714359002378 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 714359002379 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 714359002380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359002381 dimer interface [polypeptide binding]; other site 714359002382 conserved gate region; other site 714359002383 putative PBP binding loops; other site 714359002384 ABC-ATPase subunit interface; other site 714359002385 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 714359002386 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 714359002387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359002388 dimer interface [polypeptide binding]; other site 714359002389 conserved gate region; other site 714359002390 putative PBP binding loops; other site 714359002391 ABC-ATPase subunit interface; other site 714359002392 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 714359002393 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 714359002394 Walker A/P-loop; other site 714359002395 ATP binding site [chemical binding]; other site 714359002396 Q-loop/lid; other site 714359002397 ABC transporter signature motif; other site 714359002398 Walker B; other site 714359002399 D-loop; other site 714359002400 H-loop/switch region; other site 714359002401 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 714359002402 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 714359002403 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 714359002404 Walker A/P-loop; other site 714359002405 ATP binding site [chemical binding]; other site 714359002406 Q-loop/lid; other site 714359002407 ABC transporter signature motif; other site 714359002408 Walker B; other site 714359002409 D-loop; other site 714359002410 H-loop/switch region; other site 714359002411 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 714359002412 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 714359002413 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 714359002414 catalytic residues [active] 714359002415 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 714359002416 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 714359002417 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 714359002418 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 714359002419 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 714359002420 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 714359002421 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359002422 non-specific DNA binding site [nucleotide binding]; other site 714359002423 salt bridge; other site 714359002424 sequence-specific DNA binding site [nucleotide binding]; other site 714359002425 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4495 714359002426 Proteins of 100 residues with WXG; Region: WXG100; cl02005 714359002427 Bacillus transposase protein; Region: Transposase_30; pfam04740 714359002428 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 714359002429 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 714359002430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359002431 putative substrate translocation pore; other site 714359002432 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 714359002433 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 714359002434 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359002435 ATP binding site [chemical binding]; other site 714359002436 Mg2+ binding site [ion binding]; other site 714359002437 G-X-G motif; other site 714359002438 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 714359002439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359002440 active site 714359002441 phosphorylation site [posttranslational modification] 714359002442 intermolecular recognition site; other site 714359002443 dimerization interface [polypeptide binding]; other site 714359002444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 714359002445 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 714359002446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 714359002447 cofactor binding site; other site 714359002448 DNA binding site [nucleotide binding] 714359002449 substrate interaction site [chemical binding]; other site 714359002450 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 714359002451 substrate interaction site [chemical binding]; other site 714359002452 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 714359002453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359002454 ATP binding site [chemical binding]; other site 714359002455 Mg2+ binding site [ion binding]; other site 714359002456 G-X-G motif; other site 714359002457 Z1 domain; Region: Z1; pfam10593 714359002458 AIPR protein; Region: AIPR; pfam10592 714359002459 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 714359002460 active site 714359002461 AIPR protein; Region: AIPR; pfam10592 714359002462 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 714359002463 replicative DNA helicase; Provisional; Region: PRK06749 714359002464 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 714359002465 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 714359002466 Walker A motif; other site 714359002467 ATP binding site [chemical binding]; other site 714359002468 Walker B motif; other site 714359002469 DNA binding loops [nucleotide binding] 714359002470 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 714359002471 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359002472 Uncharacterized phage-associated protein [Function unknown]; Region: GepA; COG3600 714359002473 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 714359002474 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359002475 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 714359002476 C-terminal domain interface [polypeptide binding]; other site 714359002477 sugar binding site [chemical binding]; other site 714359002478 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 714359002479 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 714359002480 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359002481 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359002482 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 714359002483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359002484 putative substrate translocation pore; other site 714359002485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359002486 hypothetical protein; Provisional; Region: PRK06770 714359002487 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714359002488 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359002489 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359002490 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 714359002491 Telomeric repeat-binding factor 2; Region: TRF2; pfam11611 714359002492 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 714359002493 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 714359002494 CGNR zinc finger; Region: zf-CGNR; pfam11706 714359002495 HPP family; Region: HPP; pfam04982 714359002496 Transcriptional regulators [Transcription]; Region: MarR; COG1846 714359002497 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359002498 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 714359002499 VanZ like family; Region: VanZ; cl01971 714359002500 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 714359002501 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 714359002502 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 714359002503 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359002504 dihydroxyacetone kinase; Provisional; Region: PRK14479 714359002505 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 714359002506 DAK2 domain; Region: Dak2; cl03685 714359002507 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359002508 non-specific DNA binding site [nucleotide binding]; other site 714359002509 salt bridge; other site 714359002510 sequence-specific DNA binding site [nucleotide binding]; other site 714359002511 S-layer homology domain; Region: SLH; pfam00395 714359002512 S-layer homology domain; Region: SLH; pfam00395 714359002513 S-layer homology domain; Region: SLH; pfam00395 714359002514 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 714359002515 hypothetical protein; Provisional; Region: PRK06770 714359002516 Anti-sigma-K factor rskA; Region: RskA; cl15366 714359002517 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 714359002518 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359002519 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714359002520 DNA binding residues [nucleotide binding] 714359002521 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359002522 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 714359002523 Heat induced stress protein YflT; Region: YflT; pfam11181 714359002524 CsbD-like; Region: CsbD; cl01272 714359002525 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 714359002526 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 714359002527 anti sigma factor interaction site; other site 714359002528 regulatory phosphorylation site [posttranslational modification]; other site 714359002529 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359002530 ATP binding site [chemical binding]; other site 714359002531 Mg2+ binding site [ion binding]; other site 714359002532 G-X-G motif; other site 714359002533 RNA polymerase sigma-B factor; Region: Sigma_B; TIGR02941 714359002534 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359002535 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 714359002536 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714359002537 DNA binding residues [nucleotide binding] 714359002538 Ferritin-like domain; Region: Ferritin; pfam00210 714359002539 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 714359002540 dinuclear metal binding motif [ion binding]; other site 714359002541 Response regulator receiver domain; Region: Response_reg; pfam00072 714359002542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359002543 active site 714359002544 phosphorylation site [posttranslational modification] 714359002545 intermolecular recognition site; other site 714359002546 dimerization interface [polypeptide binding]; other site 714359002547 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 714359002548 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 714359002549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 714359002550 CHASE3 domain; Region: CHASE3; cl05000 714359002551 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 714359002552 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359002553 dimer interface [polypeptide binding]; other site 714359002554 phosphorylation site [posttranslational modification] 714359002555 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359002556 ATP binding site [chemical binding]; other site 714359002557 Mg2+ binding site [ion binding]; other site 714359002558 G-X-G motif; other site 714359002559 Response regulator receiver domain; Region: Response_reg; pfam00072 714359002560 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359002561 active site 714359002562 phosphorylation site [posttranslational modification] 714359002563 intermolecular recognition site; other site 714359002564 dimerization interface [polypeptide binding]; other site 714359002565 Domain of unknown function (DUF74); Region: DUF74; cl00426 714359002566 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 714359002567 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 714359002568 NADP binding site [chemical binding]; other site 714359002569 dimer interface [polypeptide binding]; other site 714359002570 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 714359002571 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 714359002572 active site 714359002573 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 714359002574 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 714359002575 active site 714359002576 metal binding site [ion binding]; metal-binding site 714359002577 Uncharacterized conserved protein [Function unknown]; Region: COG4717 714359002578 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 714359002579 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 714359002580 generic binding surface II; other site 714359002581 generic binding surface I; other site 714359002582 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 714359002583 Zn2+ binding site [ion binding]; other site 714359002584 Mg2+ binding site [ion binding]; other site 714359002585 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 714359002586 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359002587 Zn binding site [ion binding]; other site 714359002588 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 714359002589 Zn binding site [ion binding]; other site 714359002590 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 714359002591 Zn binding site [ion binding]; other site 714359002592 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 714359002593 Zn binding site [ion binding]; other site 714359002594 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359002595 homoserine O-acetyltransferase; Provisional; Region: metX; cl15472 714359002596 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 714359002597 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 714359002598 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 714359002599 Cupin domain; Region: Cupin_2; cl09118 714359002600 Cupin domain; Region: Cupin_2; cl09118 714359002601 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 714359002602 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 714359002603 amphipathic channel; other site 714359002604 Asn-Pro-Ala signature motifs; other site 714359002605 glycerol kinase; Provisional; Region: glpK; PRK00047 714359002606 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 714359002607 N- and C-terminal domain interface [polypeptide binding]; other site 714359002608 active site 714359002609 MgATP binding site [chemical binding]; other site 714359002610 catalytic site [active] 714359002611 metal binding site [ion binding]; metal-binding site 714359002612 glycerol binding site [chemical binding]; other site 714359002613 homotetramer interface [polypeptide binding]; other site 714359002614 homodimer interface [polypeptide binding]; other site 714359002615 FBP binding site [chemical binding]; other site 714359002616 protein IIAGlc interface [polypeptide binding]; other site 714359002617 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 714359002618 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359002619 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 714359002620 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359002621 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714359002622 DNA binding residues [nucleotide binding] 714359002623 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 714359002624 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 714359002625 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359002626 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 714359002627 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 714359002628 Protein export membrane protein; Region: SecD_SecF; cl14618 714359002629 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 714359002630 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359002631 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359002632 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 714359002633 PPIC-type PPIASE domain; Region: Rotamase; cl08278 714359002634 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 714359002635 transcriptional regulator Hpr; Provisional; Region: PRK13777 714359002636 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359002637 YtxH-like protein; Region: YtxH; cl02079 714359002638 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 714359002639 HIT family signature motif; other site 714359002640 catalytic residue [active] 714359002641 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 714359002642 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 714359002643 Walker A/P-loop; other site 714359002644 ATP binding site [chemical binding]; other site 714359002645 Q-loop/lid; other site 714359002646 ABC transporter signature motif; other site 714359002647 Walker B; other site 714359002648 D-loop; other site 714359002649 H-loop/switch region; other site 714359002650 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 714359002651 EcsC protein family; Region: EcsC; pfam12787 714359002652 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359002653 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359002654 Bacterial membrane flanked domain; Region: DUF304; cl01348 714359002655 Predicted membrane protein [Function unknown]; Region: COG3428 714359002656 Bacterial membrane flanked domain; Region: DUF304; cl01348 714359002657 Bacterial membrane flanked domain; Region: DUF304; cl01348 714359002658 Bacterial membrane flanked domain; Region: DUF304; cl01348 714359002659 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359002660 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359002661 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 714359002662 EamA-like transporter family; Region: EamA; cl01037 714359002663 EamA-like transporter family; Region: EamA; cl01037 714359002664 Bacterial membrane flanked domain; Region: DUF304; cl01348 714359002665 Predicted membrane protein [Function unknown]; Region: COG3428 714359002666 Bacterial membrane flanked domain; Region: DUF304; cl01348 714359002667 Protein of unknown function, DUF485; Region: DUF485; cl01231 714359002668 Bacterial membrane flanked domain; Region: DUF304; cl01348 714359002669 Bacterial membrane flanked domain; Region: DUF304; cl01348 714359002670 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 714359002671 Transglycosylase; Region: Transgly; cl07896 714359002672 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 714359002673 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359002674 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 714359002675 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 714359002676 substrate binding site [chemical binding]; other site 714359002677 active site 714359002678 ferrochelatase; Provisional; Region: PRK12435 714359002679 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 714359002680 C-terminal domain interface [polypeptide binding]; other site 714359002681 active site 714359002682 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 714359002683 active site 714359002684 N-terminal domain interface [polypeptide binding]; other site 714359002685 protoporphyrinogen oxidase; Region: proto_IX_ox; TIGR00562 714359002686 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359002687 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; cl01543 714359002688 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 714359002689 generic binding surface I; other site 714359002690 generic binding surface II; other site 714359002691 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 714359002692 putative active site [active] 714359002693 putative catalytic site [active] 714359002694 putative Mg binding site IVb [ion binding]; other site 714359002695 putative phosphate binding site [ion binding]; other site 714359002696 putative DNA binding site [nucleotide binding]; other site 714359002697 putative Mg binding site IVa [ion binding]; other site 714359002698 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359002699 Peptidase family M48; Region: Peptidase_M48; cl12018 714359002700 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359002701 Predicted membrane protein [Function unknown]; Region: COG1511 714359002702 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 714359002703 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 714359002704 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 714359002705 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 714359002706 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 714359002707 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 714359002708 ABC-2 type transporter; Region: ABC2_membrane; cl11417 714359002709 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 714359002710 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714359002711 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359002712 Coenzyme A binding pocket [chemical binding]; other site 714359002713 Transcriptional regulators [Transcription]; Region: PurR; COG1609 714359002714 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 714359002715 DNA binding site [nucleotide binding] 714359002716 domain linker motif; other site 714359002717 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 714359002718 putative dimerization interface [polypeptide binding]; other site 714359002719 putative ligand binding site [chemical binding]; other site 714359002720 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 714359002721 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 714359002722 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 714359002723 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 714359002724 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359002725 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 714359002726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359002727 dimer interface [polypeptide binding]; other site 714359002728 conserved gate region; other site 714359002729 putative PBP binding loops; other site 714359002730 ABC-ATPase subunit interface; other site 714359002731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359002732 dimer interface [polypeptide binding]; other site 714359002733 conserved gate region; other site 714359002734 putative PBP binding loops; other site 714359002735 ABC-ATPase subunit interface; other site 714359002736 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 714359002737 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296 714359002738 Walker A/P-loop; other site 714359002739 ATP binding site [chemical binding]; other site 714359002740 Q-loop/lid; other site 714359002741 ABC transporter signature motif; other site 714359002742 Walker B; other site 714359002743 D-loop; other site 714359002744 H-loop/switch region; other site 714359002745 TOBE domain; Region: TOBE_2; cl01440 714359002746 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 714359002747 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 714359002748 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 714359002749 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 714359002750 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 714359002751 putative active site [active] 714359002752 putative metal binding site [ion binding]; other site 714359002753 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 714359002754 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 714359002755 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714359002756 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 714359002757 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714359002758 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 714359002759 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359002760 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 714359002761 active site 714359002762 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359002763 dimer interface [polypeptide binding]; other site 714359002764 phosphorylation site [posttranslational modification] 714359002765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359002766 ATP binding site [chemical binding]; other site 714359002767 Mg2+ binding site [ion binding]; other site 714359002768 G-X-G motif; other site 714359002769 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359002770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359002771 active site 714359002772 phosphorylation site [posttranslational modification] 714359002773 intermolecular recognition site; other site 714359002774 dimerization interface [polypeptide binding]; other site 714359002775 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359002776 DNA binding site [nucleotide binding] 714359002777 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 714359002778 Peptidase family M48; Region: Peptidase_M48; cl12018 714359002779 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 714359002780 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359002781 dimerization interface [polypeptide binding]; other site 714359002782 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 714359002783 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These transmembrane...; Region: TarH; cl00144 714359002784 S-layer homology domain; Region: SLH; pfam00395 714359002785 S-layer homology domain; Region: SLH; pfam00395 714359002786 S-layer homology domain; Region: SLH; pfam00395 714359002787 S-layer homology domain; Region: SLH; pfam00395 714359002788 S-layer homology domain; Region: SLH; pfam00395 714359002789 S-layer homology domain; Region: SLH; pfam00395 714359002790 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 714359002791 active site 714359002792 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 714359002793 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 714359002794 tetramer interface [polypeptide binding]; other site 714359002795 active site 714359002796 Mg2+/Mn2+ binding site [ion binding]; other site 714359002797 Phosphotransferase enzyme family; Region: APH; pfam01636 714359002798 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 714359002799 active site 714359002800 substrate binding site [chemical binding]; other site 714359002801 ATP binding site [chemical binding]; other site 714359002802 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 714359002803 DNA-binding site [nucleotide binding]; DNA binding site 714359002804 RNA-binding motif; other site 714359002805 ComK protein; Region: ComK; cl11560 714359002806 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 714359002807 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 714359002808 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 714359002809 Catalytic site [active] 714359002810 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 714359002811 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 714359002812 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; cl15476 714359002813 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 714359002814 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 714359002815 helicase-exonuclease AddAB, AddA subunit; Region: addA_Gpos; TIGR02785 714359002816 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359002817 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359002818 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 714359002819 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 714359002820 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 714359002821 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 714359002822 Spore germination protein GerPC; Region: GerPC; pfam10737 714359002823 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 714359002824 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 714359002825 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 714359002826 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 714359002827 inhibitor-cofactor binding pocket; inhibition site 714359002828 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359002829 catalytic residue [active] 714359002830 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 714359002831 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 714359002832 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 714359002833 active site 714359002834 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 714359002835 dimer interface [polypeptide binding]; other site 714359002836 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 714359002837 Ligand Binding Site [chemical binding]; other site 714359002838 Molecular Tunnel; other site 714359002839 ferrochelatase; Provisional; Region: PRK12435 714359002840 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 714359002841 C-terminal domain interface [polypeptide binding]; other site 714359002842 active site 714359002843 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 714359002844 active site 714359002845 N-terminal domain interface [polypeptide binding]; other site 714359002846 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 714359002847 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 714359002848 tetramer interface [polypeptide binding]; other site 714359002849 heme binding pocket [chemical binding]; other site 714359002850 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 714359002851 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 714359002852 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 714359002853 maltodextrin glucosidase; Provisional; Region: PRK10785 714359002854 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359002855 non-specific DNA binding site [nucleotide binding]; other site 714359002856 salt bridge; other site 714359002857 sequence-specific DNA binding site [nucleotide binding]; other site 714359002858 Protein of unknown function (DUF520); Region: DUF520; cl00723 714359002859 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 714359002860 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 714359002861 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 714359002862 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 714359002863 RHS Repeat; Region: RHS_repeat; cl11982 714359002864 RHS Repeat; Region: RHS_repeat; cl11982 714359002865 RHS protein; Region: RHS; pfam03527 714359002866 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 714359002867 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 714359002868 PPIC-type PPIASE domain; Region: Rotamase; cl08278 714359002869 Uncharacterized conserved protein [Function unknown]; Region: COG1284 714359002870 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 714359002871 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 714359002872 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 714359002873 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 714359002874 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 714359002875 Clp amino terminal domain; Region: Clp_N; pfam02861 714359002876 Clp amino terminal domain; Region: Clp_N; pfam02861 714359002877 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359002878 Walker A motif; other site 714359002879 ATP binding site [chemical binding]; other site 714359002880 Walker B motif; other site 714359002881 arginine finger; other site 714359002882 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359002883 Walker A motif; other site 714359002884 ATP binding site [chemical binding]; other site 714359002885 Walker B motif; other site 714359002886 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 714359002887 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 714359002888 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 714359002889 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 714359002890 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359002891 ComZ; Region: ComZ; pfam10815 714359002892 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 714359002893 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 714359002894 dimer interface [polypeptide binding]; other site 714359002895 active site 714359002896 CoA binding pocket [chemical binding]; other site 714359002897 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 714359002898 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 714359002899 dimer interface [polypeptide binding]; other site 714359002900 active site 714359002901 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 714359002902 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 714359002903 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 714359002904 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 714359002905 active site 714359002906 HIGH motif; other site 714359002907 dimer interface [polypeptide binding]; other site 714359002908 KMSKS motif; other site 714359002909 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 714359002910 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 714359002911 peptide binding site [polypeptide binding]; other site 714359002912 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 714359002913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359002914 dimer interface [polypeptide binding]; other site 714359002915 conserved gate region; other site 714359002916 putative PBP binding loops; other site 714359002917 ABC-ATPase subunit interface; other site 714359002918 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 714359002919 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 714359002920 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359002921 dimer interface [polypeptide binding]; other site 714359002922 conserved gate region; other site 714359002923 putative PBP binding loops; other site 714359002924 ABC-ATPase subunit interface; other site 714359002925 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 714359002926 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 714359002927 Walker A/P-loop; other site 714359002928 ATP binding site [chemical binding]; other site 714359002929 Q-loop/lid; other site 714359002930 ABC transporter signature motif; other site 714359002931 Walker B; other site 714359002932 D-loop; other site 714359002933 H-loop/switch region; other site 714359002934 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 714359002935 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 714359002936 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 714359002937 Walker A/P-loop; other site 714359002938 ATP binding site [chemical binding]; other site 714359002939 Q-loop/lid; other site 714359002940 ABC transporter signature motif; other site 714359002941 Walker B; other site 714359002942 D-loop; other site 714359002943 H-loop/switch region; other site 714359002944 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 714359002945 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 714359002946 MatE; Region: MatE; cl10513 714359002947 MatE; Region: MatE; cl10513 714359002948 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 714359002949 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 714359002950 peptide binding site [polypeptide binding]; other site 714359002951 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 714359002952 ArsC family; Region: ArsC; pfam03960 714359002953 putative catalytic residues [active] 714359002954 thiol/disulfide switch; other site 714359002955 Integral membrane protein TerC family; Region: TerC; cl10468 714359002956 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 714359002957 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 714359002958 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 714359002959 putative active site [active] 714359002960 catalytic site [active] 714359002961 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 714359002962 putative active site [active] 714359002963 catalytic site [active] 714359002964 Competence protein CoiA-like family; Region: CoiA; cl11541 714359002965 oligoendopeptidase F; Region: pepF; TIGR00181 714359002966 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 714359002967 active site 714359002968 Zn binding site [ion binding]; other site 714359002969 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 714359002970 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 714359002971 catalytic residues [active] 714359002972 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 714359002973 apolar tunnel; other site 714359002974 heme binding site [chemical binding]; other site 714359002975 dimerization interface [polypeptide binding]; other site 714359002976 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 714359002977 putative active site [active] 714359002978 putative metal binding residues [ion binding]; other site 714359002979 signature motif; other site 714359002980 putative triphosphate binding site [ion binding]; other site 714359002981 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 714359002982 synthetase active site [active] 714359002983 NTP binding site [chemical binding]; other site 714359002984 metal binding site [ion binding]; metal-binding site 714359002985 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 714359002986 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 714359002987 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 714359002988 active site 714359002989 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 714359002990 Hep_Hag; Region: Hep_Hag; pfam05658 714359002991 Domain of unknown function (DUF3476); Region: DUF3476; pfam11962 714359002992 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 714359002993 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 714359002994 active site 714359002995 metal binding site [ion binding]; metal-binding site 714359002996 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 714359002997 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 714359002998 active site 714359002999 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359003000 S-adenosylmethionine binding site [chemical binding]; other site 714359003001 Macrocin-O-methyltransferase (TylF); Region: TylF; pfam05711 714359003002 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 714359003003 putative metal binding site; other site 714359003004 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359003005 binding surface 714359003006 TPR motif; other site 714359003007 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359003008 S-adenosylmethionine binding site [chemical binding]; other site 714359003009 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 714359003010 catalytic residues [active] 714359003011 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 714359003012 active site 714359003013 Cupin domain; Region: Cupin_2; cl09118 714359003014 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 714359003015 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 714359003016 NAD binding site [chemical binding]; other site 714359003017 substrate binding site [chemical binding]; other site 714359003018 homodimer interface [polypeptide binding]; other site 714359003019 active site 714359003020 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 714359003021 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 714359003022 NADP binding site [chemical binding]; other site 714359003023 active site 714359003024 putative substrate binding site [chemical binding]; other site 714359003025 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 714359003026 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 714359003027 NAD binding site [chemical binding]; other site 714359003028 homotetramer interface [polypeptide binding]; other site 714359003029 homodimer interface [polypeptide binding]; other site 714359003030 substrate binding site [chemical binding]; other site 714359003031 active site 714359003032 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 714359003033 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 714359003034 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 714359003035 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 714359003036 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359003037 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359003038 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359003039 Coenzyme A binding pocket [chemical binding]; other site 714359003040 hypothetical protein; Provisional; Region: PRK13679 714359003041 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 714359003042 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 714359003043 Putative esterase; Region: Esterase; pfam00756 714359003044 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 714359003045 EamA-like transporter family; Region: EamA; cl01037 714359003046 EamA-like transporter family; Region: EamA; cl01037 714359003047 Protein of unknown function (DUF1200); Region: DUF1200; pfam06713 714359003048 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 714359003049 Pectate lyase; Region: Pectate_lyase; pfam03211 714359003050 Sodium:solute symporter family; Region: SSF; cl00456 714359003051 anthranilate synthase component I; Provisional; Region: PRK13570 714359003052 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 714359003053 chorismate binding enzyme; Region: Chorismate_bind; cl10555 714359003054 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 714359003055 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 714359003056 glutamine binding [chemical binding]; other site 714359003057 catalytic triad [active] 714359003058 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 714359003059 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 714359003060 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 714359003061 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 714359003062 active site 714359003063 ribulose/triose binding site [chemical binding]; other site 714359003064 phosphate binding site [ion binding]; other site 714359003065 substrate (anthranilate) binding pocket [chemical binding]; other site 714359003066 product (indole) binding pocket [chemical binding]; other site 714359003067 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 714359003068 active site 714359003069 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 714359003070 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 714359003071 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359003072 catalytic residue [active] 714359003073 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 714359003074 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 714359003075 substrate binding site [chemical binding]; other site 714359003076 active site 714359003077 catalytic residues [active] 714359003078 heterodimer interface [polypeptide binding]; other site 714359003079 L-lactate permease; Region: Lactate_perm; cl00701 714359003080 Uncharacterized conserved protein [Function unknown]; Region: COG5634 714359003081 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 714359003082 Predicted membrane protein [Function unknown]; Region: COG4640 714359003083 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 714359003084 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359003085 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 714359003086 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 714359003087 NADPH bind site [chemical binding]; other site 714359003088 putative FMN binding site [chemical binding]; other site 714359003089 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 714359003090 putative FMN binding site [chemical binding]; other site 714359003091 MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816 714359003092 YcaO-like family; Region: YcaO; cl09146 714359003093 MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816 714359003094 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 714359003095 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 714359003096 E3 interaction surface; other site 714359003097 lipoyl attachment site [posttranslational modification]; other site 714359003098 e3 binding domain; Region: E3_binding; pfam02817 714359003099 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 714359003100 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 714359003101 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 714359003102 TPP-binding site [chemical binding]; other site 714359003103 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 714359003104 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359003105 salt bridge; other site 714359003106 non-specific DNA binding site [nucleotide binding]; other site 714359003107 sequence-specific DNA binding site [nucleotide binding]; other site 714359003108 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 714359003109 This subfamily is involved in drug resistance, nodulation, lipid transport, and bacteriocin and lantibiotic immunity. In eubacteria and archaea, the typical organization consists of one ABC and one or two IMs. Eukaryote systems of the ABCA subfamily...; Region: ABC_putative_ATPase; cd03269 714359003110 Walker A/P-loop; other site 714359003111 ATP binding site [chemical binding]; other site 714359003112 Q-loop/lid; other site 714359003113 ABC transporter signature motif; other site 714359003114 Walker B; other site 714359003115 D-loop; other site 714359003116 H-loop/switch region; other site 714359003117 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 714359003118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359003119 S-adenosylmethionine binding site [chemical binding]; other site 714359003120 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 714359003121 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359003122 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 714359003123 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 714359003124 Catalytic site [active] 714359003125 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 714359003126 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 714359003127 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359003128 non-specific DNA binding site [nucleotide binding]; other site 714359003129 salt bridge; other site 714359003130 sequence-specific DNA binding site [nucleotide binding]; other site 714359003131 Anti-repressor SinI; Region: SinI; pfam08671 714359003132 Anti-repressor SinI; Region: SinI; pfam08671 714359003133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 714359003134 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 714359003135 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 714359003136 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 714359003137 NAD(P) binding site [chemical binding]; other site 714359003138 catalytic residues [active] 714359003139 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 714359003140 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 714359003141 Walker A/P-loop; other site 714359003142 ATP binding site [chemical binding]; other site 714359003143 Q-loop/lid; other site 714359003144 ABC transporter signature motif; other site 714359003145 Walker B; other site 714359003146 D-loop; other site 714359003147 H-loop/switch region; other site 714359003148 TOBE domain; Region: TOBE_2; cl01440 714359003149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359003150 dimer interface [polypeptide binding]; other site 714359003151 conserved gate region; other site 714359003152 putative PBP binding loops; other site 714359003153 ABC-ATPase subunit interface; other site 714359003154 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 714359003155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359003156 dimer interface [polypeptide binding]; other site 714359003157 conserved gate region; other site 714359003158 putative PBP binding loops; other site 714359003159 ABC-ATPase subunit interface; other site 714359003160 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 714359003161 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 714359003162 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 714359003163 active site 714359003164 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 714359003165 Protein export membrane protein; Region: SecD_SecF; cl14618 714359003166 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 714359003167 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 714359003168 active site 714359003169 Protein of unknown function (DUF1648); Region: DUF1648; cl01712 714359003170 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 714359003171 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 714359003172 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 714359003173 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 714359003174 Cysteine-rich domain; Region: CCG; pfam02754 714359003175 Cysteine-rich domain; Region: CCG; pfam02754 714359003176 FAD binding domain; Region: FAD_binding_4; pfam01565 714359003177 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 714359003178 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 714359003179 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 714359003180 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 714359003181 metal binding site [ion binding]; metal-binding site 714359003182 Uncharacterized conserved protein [Function unknown]; Region: COG3391 714359003183 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 714359003184 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 714359003185 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359003186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359003187 active site 714359003188 phosphorylation site [posttranslational modification] 714359003189 intermolecular recognition site; other site 714359003190 dimerization interface [polypeptide binding]; other site 714359003191 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359003192 DNA binding site [nucleotide binding] 714359003193 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359003194 dimerization interface [polypeptide binding]; other site 714359003195 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359003196 dimer interface [polypeptide binding]; other site 714359003197 phosphorylation site [posttranslational modification] 714359003198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359003199 ATP binding site [chemical binding]; other site 714359003200 Mg2+ binding site [ion binding]; other site 714359003201 G-X-G motif; other site 714359003202 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359003203 DNA-binding site [nucleotide binding]; DNA binding site 714359003204 FCD domain; Region: FCD; cl11656 714359003205 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 714359003206 Cysteine-rich domain; Region: CCG; pfam02754 714359003207 Cysteine-rich domain; Region: CCG; pfam02754 714359003208 iron-sulfur cluster-binding protein; Region: TIGR00273 714359003209 Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674 714359003210 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 714359003211 Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674 714359003212 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 714359003213 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 714359003214 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 714359003215 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 714359003216 Integral membrane protein TerC family; Region: TerC; cl10468 714359003217 Cation transport protein; Region: TrkH; cl10514 714359003218 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 714359003219 Cation transport protein; Region: TrkH; cl10514 714359003220 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 714359003221 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 714359003222 dimer interaction site [polypeptide binding]; other site 714359003223 substrate-binding tunnel; other site 714359003224 active site 714359003225 catalytic site [active] 714359003226 substrate binding site [chemical binding]; other site 714359003227 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 714359003228 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 714359003229 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 714359003230 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 714359003231 NAD(P) binding site [chemical binding]; other site 714359003232 homotetramer interface [polypeptide binding]; other site 714359003233 homodimer interface [polypeptide binding]; other site 714359003234 active site 714359003235 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 714359003236 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 714359003237 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 714359003238 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 714359003239 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359003240 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 714359003241 Cation transport protein; Region: TrkH; cl10514 714359003242 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 714359003243 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 714359003244 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 714359003245 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359003246 Walker A/P-loop; other site 714359003247 ATP binding site [chemical binding]; other site 714359003248 Q-loop/lid; other site 714359003249 ABC transporter signature motif; other site 714359003250 Walker B; other site 714359003251 D-loop; other site 714359003252 H-loop/switch region; other site 714359003253 TOBE domain; Region: TOBE_2; cl01440 714359003254 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 714359003255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359003256 dimer interface [polypeptide binding]; other site 714359003257 conserved gate region; other site 714359003258 putative PBP binding loops; other site 714359003259 ABC-ATPase subunit interface; other site 714359003260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359003261 dimer interface [polypeptide binding]; other site 714359003262 conserved gate region; other site 714359003263 putative PBP binding loops; other site 714359003264 ABC-ATPase subunit interface; other site 714359003265 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 714359003266 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359003267 motif II; other site 714359003268 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 714359003269 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 714359003270 catalytic residue [active] 714359003271 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 714359003272 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 714359003273 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359003274 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 714359003275 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 714359003276 heme-binding site [chemical binding]; other site 714359003277 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 714359003278 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 714359003279 Substrate binding site [chemical binding]; other site 714359003280 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 714359003281 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 714359003282 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 714359003283 Leucine-rich repeats; other site 714359003284 Substrate binding site [chemical binding]; other site 714359003285 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 714359003286 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 714359003287 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 714359003288 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 714359003289 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 714359003290 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 714359003291 LRR adjacent; Region: LRR_adjacent; pfam08191 714359003292 S-layer homology domain; Region: SLH; pfam00395 714359003293 S-layer homology domain; Region: SLH; pfam00395 714359003294 S-layer homology domain; Region: SLH; pfam00395 714359003295 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 714359003296 intersubunit interface [polypeptide binding]; other site 714359003297 active site 714359003298 Zn2+ binding site [ion binding]; other site 714359003299 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 714359003300 Divergent polysaccharide deacetylase; Region: Polysacc_deac_2; cl04721 714359003301 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 714359003302 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 714359003303 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359003304 dimer interface [polypeptide binding]; other site 714359003305 phosphorylation site [posttranslational modification] 714359003306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359003307 ATP binding site [chemical binding]; other site 714359003308 Mg2+ binding site [ion binding]; other site 714359003309 G-X-G motif; other site 714359003310 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359003311 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 714359003312 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 714359003313 active site 714359003314 Zn binding site [ion binding]; other site 714359003315 DinB superfamily; Region: DinB_2; cl00986 714359003316 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 714359003317 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359003318 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359003319 dimer interface [polypeptide binding]; other site 714359003320 phosphorylation site [posttranslational modification] 714359003321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359003322 ATP binding site [chemical binding]; other site 714359003323 Mg2+ binding site [ion binding]; other site 714359003324 G-X-G motif; other site 714359003325 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 714359003326 Ligand Binding Site [chemical binding]; other site 714359003327 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 714359003328 active site 714359003329 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 714359003330 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 714359003331 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359003332 Coenzyme A binding pocket [chemical binding]; other site 714359003333 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 714359003334 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 714359003335 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 714359003336 Class I ribonucleotide reductase; Region: RNR_I; cd01679 714359003337 active site 714359003338 dimer interface [polypeptide binding]; other site 714359003339 catalytic residues [active] 714359003340 effector binding site; other site 714359003341 R2 peptide binding site; other site 714359003342 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 714359003343 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 714359003344 dimer interface [polypeptide binding]; other site 714359003345 putative radical transfer pathway; other site 714359003346 diiron center [ion binding]; other site 714359003347 tyrosyl radical; other site 714359003348 Predicted transcriptional regulators [Transcription]; Region: COG1725 714359003349 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359003350 DNA-binding site [nucleotide binding]; DNA binding site 714359003351 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 714359003352 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 714359003353 Walker A/P-loop; other site 714359003354 ATP binding site [chemical binding]; other site 714359003355 Q-loop/lid; other site 714359003356 ABC transporter signature motif; other site 714359003357 Walker B; other site 714359003358 D-loop; other site 714359003359 H-loop/switch region; other site 714359003360 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 714359003361 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359003362 Walker A/P-loop; other site 714359003363 ATP binding site [chemical binding]; other site 714359003364 Q-loop/lid; other site 714359003365 ABC transporter signature motif; other site 714359003366 Walker B; other site 714359003367 D-loop; other site 714359003368 H-loop/switch region; other site 714359003369 ABC-2 type transporter; Region: ABC2_membrane; cl11417 714359003370 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 714359003371 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 714359003372 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 714359003373 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359003374 Uncharacterized conserved protein [Function unknown]; Region: COG2128 714359003375 Isochorismatase family; Region: Isochorismatase; pfam00857 714359003376 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 714359003377 catalytic triad [active] 714359003378 conserved cis-peptide bond; other site 714359003379 SseB protein; Region: SseB; cl06279 714359003380 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 714359003381 dimer interface [polypeptide binding]; other site 714359003382 catalytic triad [active] 714359003383 Nitronate monooxygenase; Region: NMO; pfam03060 714359003384 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 714359003385 FMN binding site [chemical binding]; other site 714359003386 substrate binding site [chemical binding]; other site 714359003387 putative catalytic residue [active] 714359003388 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 714359003389 DltD N-terminal region; Region: DltD_N; pfam04915 714359003390 DltD central region; Region: DltD_M; pfam04918 714359003391 DltD C-terminal region; Region: DltD_C; pfam04914 714359003392 Phosphopantetheine attachment site; Region: PP-binding; cl09936 714359003393 MBOAT family; Region: MBOAT; cl00738 714359003394 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359003395 D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734 714359003396 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 714359003397 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 714359003398 metal binding site [ion binding]; metal-binding site 714359003399 dimer interface [polypeptide binding]; other site 714359003400 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 714359003401 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 714359003402 Phosphotransferase enzyme family; Region: APH; pfam01636 714359003403 active site 714359003404 substrate binding site [chemical binding]; other site 714359003405 ATP binding site [chemical binding]; other site 714359003406 multidrug efflux protein; Reviewed; Region: PRK01766 714359003407 MatE; Region: MatE; cl10513 714359003408 MatE; Region: MatE; cl10513 714359003409 Bacitracin resistance protein BacA; Region: BacA; cl00858 714359003410 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 714359003411 catalytic residues [active] 714359003412 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359003413 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 714359003414 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 714359003415 Cation transport protein; Region: TrkH; cl10514 714359003416 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 714359003417 Uncharacterised protein family (UPF0180); Region: UPF0180; cl04214 714359003418 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 714359003419 homodimer interface [polypeptide binding]; other site 714359003420 substrate-cofactor binding pocket; other site 714359003421 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359003422 Aminotransferase class IV; Region: Aminotran_4; pfam01063 714359003423 catalytic residue [active] 714359003424 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 714359003425 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 714359003426 PYR/PP interface [polypeptide binding]; other site 714359003427 dimer interface [polypeptide binding]; other site 714359003428 TPP binding site [chemical binding]; other site 714359003429 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 714359003430 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 714359003431 TPP-binding site [chemical binding]; other site 714359003432 dimer interface [polypeptide binding]; other site 714359003433 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 714359003434 ketol-acid reductoisomerase; Provisional; Region: PRK05479 714359003435 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359003436 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 714359003437 2-isopropylmalate synthase; Validated; Region: PRK00915 714359003438 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 714359003439 active site 714359003440 catalytic residues [active] 714359003441 metal binding site [ion binding]; metal-binding site 714359003442 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 714359003443 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 714359003444 tartrate dehydrogenase; Provisional; Region: PRK08194 714359003445 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 714359003446 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 714359003447 substrate binding site [chemical binding]; other site 714359003448 ligand binding site [chemical binding]; other site 714359003449 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 714359003450 substrate binding site [chemical binding]; other site 714359003451 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 714359003452 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 714359003453 dimer interface [polypeptide binding]; other site 714359003454 motif 1; other site 714359003455 active site 714359003456 motif 2; other site 714359003457 motif 3; other site 714359003458 ATP phosphoribosyltransferase; Region: HisG; cl15266 714359003459 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 714359003460 histidinol dehydrogenase; Region: hisD; TIGR00069 714359003461 NAD binding site [chemical binding]; other site 714359003462 dimerization interface [polypeptide binding]; other site 714359003463 product binding site; other site 714359003464 substrate binding site [chemical binding]; other site 714359003465 zinc binding site [ion binding]; other site 714359003466 catalytic residues [active] 714359003467 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 714359003468 putative active site pocket [active] 714359003469 4-fold oligomerization interface [polypeptide binding]; other site 714359003470 metal binding residues [ion binding]; metal-binding site 714359003471 3-fold/trimer interface [polypeptide binding]; other site 714359003472 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 714359003473 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 714359003474 catalytic residues [active] 714359003475 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 714359003476 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 714359003477 substrate binding site [chemical binding]; other site 714359003478 glutamase interaction surface [polypeptide binding]; other site 714359003479 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 714359003480 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 714359003481 histidinol-phosphatase; Validated; Region: PRK06740 714359003482 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359003483 glyoxylate reductase; Reviewed; Region: PRK13243 714359003484 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359003485 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 714359003486 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 714359003487 Sulfatase; Region: Sulfatase; cl10460 714359003488 diaminopimelate decarboxylase; Region: lysA; TIGR01048 714359003489 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 714359003490 active site 714359003491 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 714359003492 substrate binding site [chemical binding]; other site 714359003493 catalytic residues [active] 714359003494 dimer interface [polypeptide binding]; other site 714359003495 Uncharacterized small protein (DUF2292); Region: DUF2292; cl02371 714359003496 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 714359003497 Active Sites [active] 714359003498 ATP-sulfurylase; Region: ATPS; cd00517 714359003499 active site 714359003500 HXXH motif; other site 714359003501 flexible loop; other site 714359003502 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 714359003503 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 714359003504 ligand-binding site [chemical binding]; other site 714359003505 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 714359003506 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 714359003507 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 714359003508 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 714359003509 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 714359003510 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 714359003511 putative active site [active] 714359003512 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 714359003513 putative active site [active] 714359003514 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 714359003515 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359003516 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 714359003517 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 714359003518 Peptidase family M23; Region: Peptidase_M23; pfam01551 714359003519 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 714359003520 Protein of unknown function (DUF402); Region: DUF402; cl00979 714359003521 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 714359003522 Na+/H+ antiporter family; Region: Na_H_antiporter; cl15356 714359003523 Na+/H+ antiporter family; Region: Na_H_antiporter; cl15356 714359003524 PspA/IM30 family; Region: PspA_IM30; pfam04012 714359003525 Predicted membrane protein (DUF2154); Region: DUF2154; cl12089 714359003526 Histidine kinase; Region: HisKA_3; pfam07730 714359003527 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359003528 ATP binding site [chemical binding]; other site 714359003529 Mg2+ binding site [ion binding]; other site 714359003530 G-X-G motif; other site 714359003531 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 714359003532 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359003533 active site 714359003534 phosphorylation site [posttranslational modification] 714359003535 intermolecular recognition site; other site 714359003536 dimerization interface [polypeptide binding]; other site 714359003537 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714359003538 DNA binding residues [nucleotide binding] 714359003539 dimerization interface [polypeptide binding]; other site 714359003540 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 714359003541 E3 interaction surface; other site 714359003542 lipoyl attachment site [posttranslational modification]; other site 714359003543 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 714359003544 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 714359003545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359003546 S-adenosylmethionine binding site [chemical binding]; other site 714359003547 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 714359003548 active site 714359003549 putative substrate binding region [chemical binding]; other site 714359003550 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 714359003551 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 714359003552 heme-binding site [chemical binding]; other site 714359003553 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 714359003554 FAD binding pocket [chemical binding]; other site 714359003555 FAD binding motif [chemical binding]; other site 714359003556 phosphate binding motif [ion binding]; other site 714359003557 beta-alpha-beta structure motif; other site 714359003558 NAD binding pocket [chemical binding]; other site 714359003559 Heme binding pocket [chemical binding]; other site 714359003560 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 714359003561 ligand binding site [chemical binding]; other site 714359003562 flexible hinge region; other site 714359003563 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359003564 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 714359003565 Phosphate transporter family; Region: PHO4; cl00396 714359003566 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 714359003567 Transglycosylase; Region: Transgly; cl07896 714359003568 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 714359003569 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359003570 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 714359003571 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 714359003572 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 714359003573 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359003574 dimer interface [polypeptide binding]; other site 714359003575 phosphorylation site [posttranslational modification] 714359003576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359003577 ATP binding site [chemical binding]; other site 714359003578 Mg2+ binding site [ion binding]; other site 714359003579 G-X-G motif; other site 714359003580 Protein of unknown function DUF72; Region: DUF72; cl00777 714359003581 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 714359003582 Phage integrase family; Region: Phage_integrase; pfam00589 714359003583 DNA binding site [nucleotide binding] 714359003584 Int/Topo IB signature motif; other site 714359003585 active site 714359003586 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359003587 dimerization interface [polypeptide binding]; other site 714359003588 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359003589 dimer interface [polypeptide binding]; other site 714359003590 phosphorylation site [posttranslational modification] 714359003591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359003592 ATP binding site [chemical binding]; other site 714359003593 Mg2+ binding site [ion binding]; other site 714359003594 G-X-G motif; other site 714359003595 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 714359003596 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 714359003597 Predicted integral membrane protein [Function unknown]; Region: COG0392 714359003598 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 714359003599 Uncharacterized conserved protein [Function unknown]; Region: COG2898 714359003600 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 714359003601 periplasmic chaperone; Provisional; Region: PRK10780 714359003602 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 714359003603 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 714359003604 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 714359003605 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 714359003606 Nucleoside recognition; Region: Gate; cl00486 714359003607 Nucleoside recognition; Region: Gate; cl00486 714359003608 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 714359003609 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714359003610 RNA binding surface [nucleotide binding]; other site 714359003611 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 714359003612 active site 714359003613 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 714359003614 catalytic residues [active] 714359003615 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 714359003616 ResB-like family; Region: ResB; pfam05140 714359003617 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 714359003618 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 714359003619 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359003620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359003621 active site 714359003622 phosphorylation site [posttranslational modification] 714359003623 intermolecular recognition site; other site 714359003624 dimerization interface [polypeptide binding]; other site 714359003625 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359003626 DNA binding site [nucleotide binding] 714359003627 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 714359003628 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359003629 dimerization interface [polypeptide binding]; other site 714359003630 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 714359003631 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359003632 dimer interface [polypeptide binding]; other site 714359003633 phosphorylation site [posttranslational modification] 714359003634 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359003635 ATP binding site [chemical binding]; other site 714359003636 Mg2+ binding site [ion binding]; other site 714359003637 G-X-G motif; other site 714359003638 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 714359003639 Peptidase family M23; Region: Peptidase_M23; pfam01551 714359003640 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 714359003641 putative peptidoglycan binding site; other site 714359003642 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 714359003643 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 714359003644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 714359003645 DEAD-like helicases superfamily; Region: DEXDc; smart00487 714359003646 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714359003647 ATP binding site [chemical binding]; other site 714359003648 putative Mg++ binding site [ion binding]; other site 714359003649 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714359003650 nucleotide binding region [chemical binding]; other site 714359003651 ATP-binding site [chemical binding]; other site 714359003652 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 714359003653 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 714359003654 putative peptidoglycan binding site; other site 714359003655 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 714359003656 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 714359003657 putative active site [active] 714359003658 putative metal binding site [ion binding]; other site 714359003659 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 714359003660 DNA binding residues [nucleotide binding] 714359003661 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 714359003662 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 714359003663 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 714359003664 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 714359003665 NAD(P) binding site [chemical binding]; other site 714359003666 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 714359003667 amidase catalytic site [active] 714359003668 Zn binding residues [ion binding]; other site 714359003669 substrate binding site [chemical binding]; other site 714359003670 putative bacillithiol system thiol disulfide oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 714359003671 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359003672 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359003673 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 714359003674 active site 714359003675 homodimer interface [polypeptide binding]; other site 714359003676 homotetramer interface [polypeptide binding]; other site 714359003677 cytidylate kinase; Provisional; Region: cmk; PRK00023 714359003678 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 714359003679 CMP-binding site; other site 714359003680 The sites determining sugar specificity; other site 714359003681 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 714359003682 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 714359003683 RNA binding site [nucleotide binding]; other site 714359003684 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 714359003685 RNA binding site [nucleotide binding]; other site 714359003686 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 714359003687 RNA binding site [nucleotide binding]; other site 714359003688 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 714359003689 RNA binding site [nucleotide binding]; other site 714359003690 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 714359003691 FMN binding site [chemical binding]; other site 714359003692 homodimer contacts [polypeptide binding]; other site 714359003693 putative active site [active] 714359003694 putative substrate binding site [chemical binding]; other site 714359003695 homotetramer interface [polypeptide binding]; other site 714359003696 GTP-binding protein Der; Reviewed; Region: PRK00093 714359003697 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA1; cd01894 714359003698 G1 box; other site 714359003699 GTP/Mg2+ binding site [chemical binding]; other site 714359003700 Switch I region; other site 714359003701 G2 box; other site 714359003702 Switch II region; other site 714359003703 G3 box; other site 714359003704 G4 box; other site 714359003705 G5 box; other site 714359003706 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA2; cd01895 714359003707 G1 box; other site 714359003708 GTP/Mg2+ binding site [chemical binding]; other site 714359003709 Switch I region; other site 714359003710 G2 box; other site 714359003711 G3 box; other site 714359003712 Switch II region; other site 714359003713 G4 box; other site 714359003714 G5 box; other site 714359003715 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 714359003716 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359003717 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 714359003718 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 714359003719 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; cl09772 714359003720 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 714359003721 IHF dimer interface [polypeptide binding]; other site 714359003722 IHF - DNA interface [nucleotide binding]; other site 714359003723 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 714359003724 homodecamer interface [polypeptide binding]; other site 714359003725 GTP cyclohydrolase I; Provisional; Region: PLN03044 714359003726 active site 714359003727 putative catalytic site residues [active] 714359003728 zinc binding site [ion binding]; other site 714359003729 GTP-CH-I/GFRP interaction surface; other site 714359003730 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 714359003731 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 714359003732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359003733 S-adenosylmethionine binding site [chemical binding]; other site 714359003734 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 714359003735 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 714359003736 substrate binding pocket [chemical binding]; other site 714359003737 chain length determination region; other site 714359003738 substrate-Mg2+ binding site; other site 714359003739 catalytic residues [active] 714359003740 aspartate-rich region 1; other site 714359003741 active site lid residues [active] 714359003742 aspartate-rich region 2; other site 714359003743 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 714359003744 active site 714359003745 multimer interface [polypeptide binding]; other site 714359003746 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 714359003747 Tetramer interface [polypeptide binding]; other site 714359003748 active site 714359003749 FMN-binding site [chemical binding]; other site 714359003750 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 714359003751 active site 714359003752 dimer interface [polypeptide binding]; other site 714359003753 metal binding site [ion binding]; metal-binding site 714359003754 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 714359003755 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714359003756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359003757 homodimer interface [polypeptide binding]; other site 714359003758 catalytic residue [active] 714359003759 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 714359003760 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 714359003761 binding surface 714359003762 TPR motif; other site 714359003763 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 714359003764 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359003765 binding surface 714359003766 TPR motif; other site 714359003767 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359003768 binding surface 714359003769 TPR motif; other site 714359003770 hypothetical protein; Provisional; Region: PRK03636 714359003771 UPF0302 domain; Region: UPF0302; pfam08864 714359003772 IDEAL domain; Region: IDEAL; cl07452 714359003773 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 714359003774 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 714359003775 iron-sulfur cluster [ion binding]; other site 714359003776 [2Fe-2S] cluster binding site [ion binding]; other site 714359003777 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 714359003778 interchain domain interface [polypeptide binding]; other site 714359003779 intrachain domain interface; other site 714359003780 heme bH binding site [chemical binding]; other site 714359003781 Qi binding site; other site 714359003782 heme bL binding site [chemical binding]; other site 714359003783 Qo binding site; other site 714359003784 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 714359003785 interchain domain interface [polypeptide binding]; other site 714359003786 intrachain domain interface; other site 714359003787 Qi binding site; other site 714359003788 Qo binding site; other site 714359003789 Cytochrome c; Region: Cytochrom_C; cl11414 714359003790 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 714359003791 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 714359003792 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 714359003793 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 714359003794 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 714359003795 active site 714359003796 Fe-S cluster binding site [ion binding]; other site 714359003797 Uncharacterized conserved protein [Function unknown]; Region: COG1284 714359003798 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 714359003799 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 714359003800 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 714359003801 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 714359003802 dihydrodipicolinate reductase; Provisional; Region: PRK00048 714359003803 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359003804 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 714359003805 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 714359003806 active site 714359003807 dimer interfaces [polypeptide binding]; other site 714359003808 catalytic residues [active] 714359003809 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 714359003810 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 714359003811 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 714359003812 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 714359003813 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 714359003814 active site 714359003815 NTP binding site [chemical binding]; other site 714359003816 metal binding triad [ion binding]; metal-binding site 714359003817 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 714359003818 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359003819 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 714359003820 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 714359003821 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 714359003822 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 714359003823 oligomerization interface [polypeptide binding]; other site 714359003824 active site 714359003825 metal binding site [ion binding]; metal-binding site 714359003826 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 714359003827 Pantoate-beta-alanine ligase; Region: PanC; cd00560 714359003828 active site 714359003829 ATP-binding site [chemical binding]; other site 714359003830 pantoate-binding site; other site 714359003831 HXXH motif; other site 714359003832 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 714359003833 tetramerization interface [polypeptide binding]; other site 714359003834 active site 714359003835 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 714359003836 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 714359003837 active site 714359003838 substrate binding site [chemical binding]; other site 714359003839 catalytic site [active] 714359003840 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359003841 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359003842 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 714359003843 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 714359003844 aspartate aminotransferase; Provisional; Region: PRK05764 714359003845 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714359003846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359003847 homodimer interface [polypeptide binding]; other site 714359003848 catalytic residue [active] 714359003849 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 714359003850 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359003851 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 714359003852 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 714359003853 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 714359003854 minor groove reading motif; other site 714359003855 helix-hairpin-helix signature motif; other site 714359003856 substrate binding pocket [chemical binding]; other site 714359003857 active site 714359003858 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 714359003859 Transglycosylase; Region: Transgly; cl07896 714359003860 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359003861 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 714359003862 Recombination protein U; Region: RecU; cl01314 714359003863 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 714359003864 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 714359003865 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 714359003866 cell division protein GpsB; Provisional; Region: PRK14127 714359003867 DivIVA domain; Region: DivI1A_domain; TIGR03544 714359003868 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 714359003869 THUMP domain; Region: THUMP; cl12076 714359003870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 714359003871 Suppressor of G2 allele of skp1 and related proteins [General function prediction only]; Region: SGT1; COG5091 714359003872 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 714359003873 TPR motif; other site 714359003874 binding surface 714359003875 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 714359003876 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359003877 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359003878 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 714359003879 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 714359003880 active site 714359003881 Zn binding site [ion binding]; other site 714359003882 putative transposase OrfB; Reviewed; Region: PHA02517 714359003883 Integrase core domain; Region: rve; cl01316 714359003884 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 714359003885 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359003886 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359003887 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 714359003888 active site 714359003889 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 714359003890 Permease family; Region: Xan_ur_permease; cl00967 714359003891 Predicted membrane protein [Function unknown]; Region: COG2311 714359003892 Protein of unknown function (DUF418); Region: DUF418; cl12135 714359003893 Protein of unknown function (DUF418); Region: DUF418; cl12135 714359003894 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 714359003895 G1 box; other site 714359003896 GTP/Mg2+ binding site [chemical binding]; other site 714359003897 Switch I region; other site 714359003898 G2 box; other site 714359003899 Switch II region; other site 714359003900 G3 box; other site 714359003901 G4 box; other site 714359003902 GTPase [General function prediction only]; Region: Era; COG1159 714359003903 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 714359003904 G1 box; other site 714359003905 GTP/Mg2+ binding site [chemical binding]; other site 714359003906 Switch I region; other site 714359003907 G2 box; other site 714359003908 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359003909 Coenzyme A binding pocket [chemical binding]; other site 714359003910 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 714359003911 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 714359003912 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 714359003913 active site residue [active] 714359003914 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 714359003915 active site residue [active] 714359003916 Glutathionylspermidine synthase; Region: GSP_synth; cl00503 714359003917 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 714359003918 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 714359003919 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 714359003920 5'-3' exonuclease; Region: 53EXOc; smart00475 714359003921 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 714359003922 active site 714359003923 metal binding site 1 [ion binding]; metal-binding site 714359003924 putative 5' ssDNA interaction site; other site 714359003925 metal binding site 3; metal-binding site 714359003926 metal binding site 2 [ion binding]; metal-binding site 714359003927 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 714359003928 putative DNA binding site [nucleotide binding]; other site 714359003929 putative metal binding site [ion binding]; other site 714359003930 OpgC protein; Region: OpgC_C; cl00792 714359003931 Chain length determinant protein; Region: Wzz; cl01623 714359003932 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 714359003933 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359003934 Bacterial sugar transferase; Region: Bac_transf; cl00939 714359003935 MatE; Region: MatE; cl10513 714359003936 colanic acid exporter; Provisional; Region: PRK10459 714359003937 O-Antigen ligase; Region: Wzy_C; cl04850 714359003938 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 714359003939 active site 714359003940 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 714359003941 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 714359003942 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359003943 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 714359003944 catalytic triad [active] 714359003945 conserved cis-peptide bond; other site 714359003946 EamA-like transporter family; Region: EamA; cl01037 714359003947 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 714359003948 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 714359003949 RNA/DNA hybrid binding site [nucleotide binding]; other site 714359003950 active site 714359003951 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 714359003952 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 714359003953 active site 714359003954 catalytic residues [active] 714359003955 QueT transporter; Region: QueT; cl01932 714359003956 hypothetical protein; Validated; Region: PRK07708 714359003957 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 714359003958 RNA/DNA hybrid binding site [nucleotide binding]; other site 714359003959 active site 714359003960 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 714359003961 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 714359003962 DNA-binding site [nucleotide binding]; DNA binding site 714359003963 RNA-binding motif; other site 714359003964 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 714359003965 LysE type translocator; Region: LysE; cl00565 714359003966 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 714359003967 Sodium:solute symporter family; Region: SSF; cl00456 714359003968 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 714359003969 aminotransferase; Validated; Region: PRK07678 714359003970 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 714359003971 inhibitor-cofactor binding pocket; inhibition site 714359003972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359003973 catalytic residue [active] 714359003974 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 714359003975 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 714359003976 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 714359003977 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 714359003978 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 714359003979 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 714359003980 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 714359003981 DNA binding residues [nucleotide binding] 714359003982 drug binding residues [chemical binding]; other site 714359003983 dimer interface [polypeptide binding]; other site 714359003984 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 714359003985 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 714359003986 MatE; Region: MatE; cl10513 714359003987 MatE; Region: MatE; cl10513 714359003988 Protein of unknown function (DUF421); Region: DUF421; cl00990 714359003989 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 714359003990 putative active site [active] 714359003991 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 714359003992 dimer interface [polypeptide binding]; other site 714359003993 FMN binding site [chemical binding]; other site 714359003994 NADPH bind site [chemical binding]; other site 714359003995 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 714359003996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359003997 putative substrate translocation pore; other site 714359003998 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 714359003999 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 714359004000 Sm1 motif; other site 714359004001 D3 - B interaction site; other site 714359004002 D1 - D2 interaction site; other site 714359004003 Hfq - Hfq interaction site; other site 714359004004 RNA binding pocket [nucleotide binding]; other site 714359004005 Sm2 motif; other site 714359004006 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 714359004007 flagellar motor protein MotP; Reviewed; Region: PRK06926 714359004008 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 714359004009 flagellar motor protein MotS; Reviewed; Region: PRK06742 714359004010 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 714359004011 ligand binding site [chemical binding]; other site 714359004012 Response regulator receiver domain; Region: Response_reg; pfam00072 714359004013 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359004014 active site 714359004015 phosphorylation site [posttranslational modification] 714359004016 intermolecular recognition site; other site 714359004017 dimerization interface [polypeptide binding]; other site 714359004018 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 714359004019 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 714359004020 putative binding surface; other site 714359004021 active site 714359004022 P2 response regulator binding domain; Region: P2; pfam07194 714359004023 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 714359004024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359004025 ATP binding site [chemical binding]; other site 714359004026 Mg2+ binding site [ion binding]; other site 714359004027 G-X-G motif; other site 714359004028 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 714359004029 flagellar motor switch protein; Reviewed; Region: PRK06782 714359004030 CheC-like family; Region: CheC; pfam04509 714359004031 CheC-like family; Region: CheC; pfam04509 714359004032 CheC-like family; Region: CheC; pfam04509 714359004033 CheC-like family; Region: CheC; pfam04509 714359004034 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 714359004035 Enolase, C-terminal TIM barrel domain; Region: Enolase_C; pfam00113 714359004036 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 714359004037 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 714359004038 DNA binding site [nucleotide binding] 714359004039 Int/Topo IB signature motif; other site 714359004040 active site 714359004041 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 714359004042 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 714359004043 Phage capsid family; Region: Phage_capsid; pfam05065 714359004044 Phage-related protein [Function unknown]; Region: COG4695; cl01923 714359004045 Phage portal protein; Region: Phage_portal; pfam04860 714359004046 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 714359004047 Phage Terminase; Region: Terminase_1; pfam03354 714359004048 Phage terminase, small subunit; Region: Terminase_4; cl01525 714359004049 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 714359004050 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 714359004051 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 714359004052 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 714359004053 Protein of unknown function (DUF327); Region: DUF327; cl00753 714359004054 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 714359004055 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 714359004056 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 714359004057 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 714359004058 flagellar capping protein; Validated; Region: fliD; PRK06798 714359004059 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 714359004060 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 714359004061 Flagellar protein FliS; Region: FliS; cl00654 714359004062 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 714359004063 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 714359004064 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 714359004065 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 714359004066 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 714359004067 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 714359004068 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 714359004069 FliG C-terminal domain; Region: FliG_C; pfam01706 714359004070 flagellar assembly protein H; Validated; Region: fliH; PRK06800 714359004071 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359004072 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 714359004073 Walker A motif; other site 714359004074 ATP binding site [chemical binding]; other site 714359004075 Walker B motif; other site 714359004076 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 714359004077 Flagellar hook capping protein; Region: FlgD; cl04347 714359004078 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 714359004079 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 714359004080 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 714359004081 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 714359004082 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 714359004083 putative CheA interaction surface; other site 714359004084 Response regulator receiver domain; Region: Response_reg; pfam00072 714359004085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359004086 active site 714359004087 phosphorylation site [posttranslational modification] 714359004088 intermolecular recognition site; other site 714359004089 dimerization interface [polypeptide binding]; other site 714359004090 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 714359004091 flagellin; Provisional; Region: PRK12807 714359004092 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 714359004093 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 714359004094 flagellin; Provisional; Region: PRK12807 714359004095 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 714359004096 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 714359004097 flagellin; Provisional; Region: PRK12807 714359004098 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 714359004099 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 714359004100 flagellin; Provisional; Region: PRK12807 714359004101 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 714359004102 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 714359004103 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 714359004104 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 714359004105 N-acetyl-D-glucosamine binding site [chemical binding]; other site 714359004106 catalytic residue [active] 714359004107 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 714359004108 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 714359004109 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 714359004110 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 714359004111 FliP family; Region: FliP; cl00593 714359004112 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 714359004113 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 714359004114 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 714359004115 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 714359004116 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 714359004117 FHIPEP family; Region: FHIPEP; pfam00771 714359004118 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK11889 714359004119 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359004120 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 714359004121 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 714359004122 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 714359004123 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 714359004124 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 714359004125 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 714359004126 Predicted transcriptional regulators [Transcription]; Region: COG1378 714359004127 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359004128 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 714359004129 C-terminal domain interface [polypeptide binding]; other site 714359004130 sugar binding site [chemical binding]; other site 714359004131 AzlC protein; Region: AzlC; cl00570 714359004132 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 714359004133 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 714359004134 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 714359004135 Small acid-soluble spore protein H family; Region: SspH; cl06949 714359004136 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359004137 non-specific DNA binding site [nucleotide binding]; other site 714359004138 salt bridge; other site 714359004139 sequence-specific DNA binding site [nucleotide binding]; other site 714359004140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359004141 H+ Antiporter protein; Region: 2A0121; TIGR00900 714359004142 putative substrate translocation pore; other site 714359004143 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 714359004144 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359004145 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 714359004146 dimerization interface [polypeptide binding]; other site 714359004147 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359004148 Q-loop/lid; other site 714359004149 ABC transporter signature motif; other site 714359004150 Walker B; other site 714359004151 D-loop; other site 714359004152 H-loop/switch region; other site 714359004153 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 714359004154 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 714359004155 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 714359004156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359004157 dimer interface [polypeptide binding]; other site 714359004158 conserved gate region; other site 714359004159 putative PBP binding loops; other site 714359004160 ABC-ATPase subunit interface; other site 714359004161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359004162 dimer interface [polypeptide binding]; other site 714359004163 conserved gate region; other site 714359004164 putative PBP binding loops; other site 714359004165 ABC-ATPase subunit interface; other site 714359004166 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 714359004167 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 714359004168 Beta-Casp domain; Region: Beta-Casp; cl12567 714359004169 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 714359004170 Uncharacterised protein from bacillus cereus group; Region: YfmQ; pfam10787 714359004171 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 714359004172 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 714359004173 catalytic core [active] 714359004174 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359004175 hypothetical protein; Provisional; Region: PRK09272 714359004176 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359004177 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 714359004178 active site 714359004179 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 714359004180 active site 714359004181 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 714359004182 dimer interface [polypeptide binding]; other site 714359004183 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 714359004184 Ligand Binding Site [chemical binding]; other site 714359004185 Molecular Tunnel; other site 714359004186 RNA polymerase factor sigma-70; Validated; Region: PRK06811 714359004187 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714359004188 DNA binding residues [nucleotide binding] 714359004189 VPS10 domain; Region: VPS10; smart00602 714359004190 VPS10 domain; Region: VPS10; smart00602 714359004191 Cation efflux family; Region: Cation_efflux; cl00316 714359004192 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 714359004193 Transcriptional regulators [Transcription]; Region: GntR; COG1802 714359004194 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359004195 DNA-binding site [nucleotide binding]; DNA binding site 714359004196 FCD domain; Region: FCD; cl11656 714359004197 EamA-like transporter family; Region: EamA; cl01037 714359004198 EamA-like transporter family; Region: EamA; cl01037 714359004199 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 714359004200 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 714359004201 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359004202 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359004203 G4 box; other site 714359004204 G5 box; other site 714359004205 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 714359004206 Predicted permease; Region: DUF318; cl00487 714359004207 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 714359004208 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 714359004209 Na+/H+ antiporter family; Region: Na_H_antiporter; cl15356 714359004210 Na+/H+ antiporter family; Region: Na_H_antiporter; cl15356 714359004211 short chain dehydrogenase; Provisional; Region: PRK06123 714359004212 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359004213 NAD(P) binding site [chemical binding]; other site 714359004214 active site 714359004215 fumarate hydratase; Reviewed; Region: fumC; PRK00485 714359004216 Class II fumarases; Region: Fumarase_classII; cd01362 714359004217 active site 714359004218 tetramer interface [polypeptide binding]; other site 714359004219 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 714359004220 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 714359004221 MatE; Region: MatE; cl10513 714359004222 MatE; Region: MatE; cl10513 714359004223 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 714359004224 active site pocket [active] 714359004225 oxyanion hole [active] 714359004226 catalytic triad [active] 714359004227 active site nucleophile [active] 714359004228 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359004229 Peptidase family M48; Region: Peptidase_M48; cl12018 714359004230 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 714359004231 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 714359004232 catalytic residues [active] 714359004233 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 714359004234 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 714359004235 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 714359004236 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359004237 non-specific DNA binding site [nucleotide binding]; other site 714359004238 salt bridge; other site 714359004239 sequence-specific DNA binding site [nucleotide binding]; other site 714359004240 Cupin domain; Region: Cupin_2; cl09118 714359004241 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 714359004242 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 714359004243 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 714359004244 catalytic residue [active] 714359004245 Protein of unknown function (DUF445); Region: DUF445; pfam04286 714359004246 RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642 714359004247 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714359004248 DNA binding residues [nucleotide binding] 714359004249 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 714359004250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359004251 active site 714359004252 phosphorylation site [posttranslational modification] 714359004253 intermolecular recognition site; other site 714359004254 dimerization interface [polypeptide binding]; other site 714359004255 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714359004256 DNA binding residues [nucleotide binding] 714359004257 dimerization interface [polypeptide binding]; other site 714359004258 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 714359004259 Histidine kinase; Region: HisKA_3; pfam07730 714359004260 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359004261 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 714359004262 Walker A/P-loop; other site 714359004263 ATP binding site [chemical binding]; other site 714359004264 Q-loop/lid; other site 714359004265 ABC transporter signature motif; other site 714359004266 Walker B; other site 714359004267 D-loop; other site 714359004268 H-loop/switch region; other site 714359004269 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 714359004270 ABC-2 type transporter; Region: ABC2_membrane; cl11417 714359004271 ABC-2 type transporter; Region: ABC2_membrane; cl11417 714359004272 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 714359004273 putative active site [active] 714359004274 catalytic site [active] 714359004275 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 714359004276 putative active site [active] 714359004277 catalytic site [active] 714359004278 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 714359004279 putative nucleotide binding site [chemical binding]; other site 714359004280 uridine monophosphate binding site [chemical binding]; other site 714359004281 homohexameric interface [polypeptide binding]; other site 714359004282 Probable transposase; Region: OrfB_IS605; pfam01385 714359004283 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 714359004284 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 714359004285 aspartate ammonia-lyase; Provisional; Region: PRK14515 714359004286 Aspartase; Region: Aspartase; cd01357 714359004287 active sites [active] 714359004288 tetramer interface [polypeptide binding]; other site 714359004289 malate dehydrogenase; Provisional; Region: PRK13529 714359004290 Malic enzyme, N-terminal domain; Region: malic; pfam00390 714359004291 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 714359004292 NAD(P) binding site [chemical binding]; other site 714359004293 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 714359004294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359004295 ATP binding site [chemical binding]; other site 714359004296 Mg2+ binding site [ion binding]; other site 714359004297 G-X-G motif; other site 714359004298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359004299 Response regulator receiver domain; Region: Response_reg; pfam00072 714359004300 active site 714359004301 phosphorylation site [posttranslational modification] 714359004302 intermolecular recognition site; other site 714359004303 dimerization interface [polypeptide binding]; other site 714359004304 YcbB domain; Region: YcbB; pfam08664 714359004305 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 714359004306 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 714359004307 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714359004308 ATP binding site [chemical binding]; other site 714359004309 putative Mg++ binding site [ion binding]; other site 714359004310 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714359004311 nucleotide binding region [chemical binding]; other site 714359004312 ATP-binding site [chemical binding]; other site 714359004313 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 714359004314 dimer interface [polypeptide binding]; other site 714359004315 active site 714359004316 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 714359004317 aspartate kinase; Reviewed; Region: PRK06635 714359004318 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 714359004319 putative nucleotide binding site [chemical binding]; other site 714359004320 putative catalytic residues [active] 714359004321 putative Mg ion binding site [ion binding]; other site 714359004322 putative aspartate binding site [chemical binding]; other site 714359004323 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 714359004324 putative allosteric regulatory site; other site 714359004325 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 714359004326 putative allosteric regulatory residue; other site 714359004327 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 714359004328 putative active site [active] 714359004329 nucleotide binding site [chemical binding]; other site 714359004330 nudix motif; other site 714359004331 putative metal binding site [ion binding]; other site 714359004332 H+ Antiporter protein; Region: 2A0121; TIGR00900 714359004333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359004334 putative substrate translocation pore; other site 714359004335 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359004336 active site 714359004337 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359004338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359004339 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359004340 putative substrate translocation pore; other site 714359004341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359004342 putative substrate translocation pore; other site 714359004343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359004344 putative substrate translocation pore; other site 714359004345 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 714359004346 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 714359004347 dimer interface [polypeptide binding]; other site 714359004348 active site 714359004349 CoA binding pocket [chemical binding]; other site 714359004350 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 714359004351 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 714359004352 G1 box; other site 714359004353 GTP/Mg2+ binding site [chemical binding]; other site 714359004354 Switch I region; other site 714359004355 G2 box; other site 714359004356 G3 box; other site 714359004357 Switch II region; other site 714359004358 G4 box; other site 714359004359 G5 box; other site 714359004360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359004361 putative substrate translocation pore; other site 714359004362 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 714359004363 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 714359004364 dimer interface [polypeptide binding]; other site 714359004365 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359004366 catalytic residue [active] 714359004367 Predicted acetyltransferase [General function prediction only]; Region: COG3981 714359004368 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 714359004369 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 714359004370 Mor transcription activator family; Region: Mor; cl02360 714359004371 Protein of unknown function (DUF421); Region: DUF421; cl00990 714359004372 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 714359004373 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 714359004374 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 714359004375 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 714359004376 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 714359004377 NADP binding site [chemical binding]; other site 714359004378 homodimer interface [polypeptide binding]; other site 714359004379 active site 714359004380 substrate binding site [chemical binding]; other site 714359004381 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 714359004382 homodimer interface [polypeptide binding]; other site 714359004383 substrate-cofactor binding pocket; other site 714359004384 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359004385 Aminotransferase class IV; Region: Aminotran_4; pfam01063 714359004386 catalytic residue [active] 714359004387 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06725 714359004388 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 714359004389 PYR/PP interface [polypeptide binding]; other site 714359004390 dimer interface [polypeptide binding]; other site 714359004391 TPP binding site [chemical binding]; other site 714359004392 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 714359004393 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 714359004394 TPP-binding site [chemical binding]; other site 714359004395 dimer interface [polypeptide binding]; other site 714359004396 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 714359004397 putative valine binding site [chemical binding]; other site 714359004398 dimer interface [polypeptide binding]; other site 714359004399 ketol-acid reductoisomerase; Provisional; Region: PRK05479 714359004400 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359004401 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 714359004402 Dehydratase family; Region: ILVD_EDD; cl00340 714359004403 threonine dehydratase; Validated; Region: PRK08639 714359004404 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 714359004405 tetramer interface [polypeptide binding]; other site 714359004406 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359004407 catalytic residue [active] 714359004408 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 714359004409 putative Ile/Val binding site [chemical binding]; other site 714359004410 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 714359004411 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 714359004412 putative active site [active] 714359004413 putative metal binding site [ion binding]; other site 714359004414 Protein of unknown function (DUF554); Region: DUF554; cl00784 714359004415 drug efflux system protein MdtG; Provisional; Region: PRK09874 714359004416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359004417 putative substrate translocation pore; other site 714359004418 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 714359004419 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 714359004420 putative active site [active] 714359004421 metal binding site [ion binding]; metal-binding site 714359004422 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 714359004423 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 714359004424 LytTr DNA-binding domain; Region: LytTR; cl04498 714359004425 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 714359004426 succinate CoA transferases; Region: YgfH_subfam; TIGR03458 714359004427 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 714359004428 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359004429 Coenzyme A binding pocket [chemical binding]; other site 714359004430 5-methylthioadenosine/S-adenosylhomocysteine deaminase; Provisional; Region: PRK15493 714359004431 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 714359004432 active site 714359004433 putative substrate binding pocket [chemical binding]; other site 714359004434 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 714359004435 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 714359004436 peptide binding site [polypeptide binding]; other site 714359004437 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359004438 S-adenosylmethionine binding site [chemical binding]; other site 714359004439 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359004440 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359004441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359004442 active site 714359004443 phosphorylation site [posttranslational modification] 714359004444 intermolecular recognition site; other site 714359004445 dimerization interface [polypeptide binding]; other site 714359004446 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359004447 DNA binding site [nucleotide binding] 714359004448 Peptidase family M23; Region: Peptidase_M23; pfam01551 714359004449 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 714359004450 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 714359004451 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 714359004452 active site residue [active] 714359004453 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 714359004454 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 714359004455 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359004456 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 714359004457 Amino acid permease; Region: AA_permease; cl00524 714359004458 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 714359004459 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 714359004460 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 714359004461 LysE type translocator; Region: LysE; cl00565 714359004462 Domain of unknown function (DUF74); Region: DUF74; cl00426 714359004463 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 714359004464 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359004465 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359004466 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 714359004467 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 714359004468 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 714359004469 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 714359004470 intersubunit interface [polypeptide binding]; other site 714359004471 active site 714359004472 catalytic residue [active] 714359004473 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 714359004474 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 714359004475 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 714359004476 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 714359004477 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 714359004478 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 714359004479 active site 714359004480 catalytic motif [active] 714359004481 Zn binding site [ion binding]; other site 714359004482 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359004483 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 714359004484 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 714359004485 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 714359004486 proline aminopeptidase P II; Provisional; Region: PRK10879 714359004487 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 714359004488 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 714359004489 active site 714359004490 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 714359004491 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 714359004492 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 714359004493 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 714359004494 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 714359004495 DNA topoisomerase III; Provisional; Region: PRK07726 714359004496 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 714359004497 active site 714359004498 putative interdomain interaction site [polypeptide binding]; other site 714359004499 putative metal-binding site [ion binding]; other site 714359004500 putative nucleotide binding site [chemical binding]; other site 714359004501 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 714359004502 domain I; other site 714359004503 DNA binding groove [nucleotide binding] 714359004504 phosphate binding site [ion binding]; other site 714359004505 domain II; other site 714359004506 domain III; other site 714359004507 nucleotide binding site [chemical binding]; other site 714359004508 catalytic site [active] 714359004509 domain IV; other site 714359004510 DNA topoisomerase III; Validated; Region: PRK08173 714359004511 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 714359004512 Membrane transport protein; Region: Mem_trans; cl09117 714359004513 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 714359004514 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 714359004515 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359004516 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 714359004517 dimer interface [polypeptide binding]; other site 714359004518 substrate binding site [chemical binding]; other site 714359004519 metal binding site [ion binding]; metal-binding site 714359004520 Copper resistance protein CopC; Region: CopC; cl01012 714359004521 Copper resistance protein D; Region: CopD; cl00563 714359004522 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 714359004523 EamA-like transporter family; Region: EamA; cl01037 714359004524 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 714359004525 EamA-like transporter family; Region: EamA; cl01037 714359004526 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714359004527 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359004528 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 714359004529 dimerization interface [polypeptide binding]; other site 714359004530 Predicted transcriptional regulator [Transcription]; Region: COG1959 714359004531 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359004532 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 714359004533 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 714359004534 catalytic residues [active] 714359004535 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 714359004536 dimer interface [polypeptide binding]; other site 714359004537 FMN binding site [chemical binding]; other site 714359004538 amidase; Provisional; Region: PRK06828 714359004539 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 714359004540 Domain of unknown function DUF20; Region: UPF0118; cl00465 714359004541 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 714359004542 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 714359004543 tetramer (dimer of dimers) interface [polypeptide binding]; other site 714359004544 NAD binding site [chemical binding]; other site 714359004545 dimer interface [polypeptide binding]; other site 714359004546 substrate binding site [chemical binding]; other site 714359004547 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 714359004548 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359004549 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 714359004550 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359004551 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 714359004552 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 714359004553 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 714359004554 putative ligand binding site [chemical binding]; other site 714359004555 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 714359004556 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 714359004557 Walker A/P-loop; other site 714359004558 ATP binding site [chemical binding]; other site 714359004559 Q-loop/lid; other site 714359004560 ABC transporter signature motif; other site 714359004561 Walker B; other site 714359004562 D-loop; other site 714359004563 H-loop/switch region; other site 714359004564 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 714359004565 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 714359004566 Walker A/P-loop; other site 714359004567 ATP binding site [chemical binding]; other site 714359004568 Q-loop/lid; other site 714359004569 ABC transporter signature motif; other site 714359004570 Walker B; other site 714359004571 D-loop; other site 714359004572 H-loop/switch region; other site 714359004573 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 714359004574 TM-ABC transporter signature motif; other site 714359004575 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 714359004576 TM-ABC transporter signature motif; other site 714359004577 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359004578 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 714359004579 dimerization interface [polypeptide binding]; other site 714359004580 Telomeric repeat-binding factor 2; Region: TRF2; pfam11611 714359004581 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359004582 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 714359004583 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 714359004584 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 714359004585 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 714359004586 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 714359004587 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 714359004588 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 714359004589 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 714359004590 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359004591 Walker A/P-loop; other site 714359004592 ATP binding site [chemical binding]; other site 714359004593 Q-loop/lid; other site 714359004594 ABC transporter signature motif; other site 714359004595 Walker B; other site 714359004596 D-loop; other site 714359004597 H-loop/switch region; other site 714359004598 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 714359004599 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 714359004600 The CYD subfamily implicated in cytochrome bd biogenesis. The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd...; Region: ABCC_cytochrome_bd; cd03247 714359004601 Walker A/P-loop; other site 714359004602 ATP binding site [chemical binding]; other site 714359004603 Q-loop/lid; other site 714359004604 ABC transporter signature motif; other site 714359004605 Walker B; other site 714359004606 D-loop; other site 714359004607 H-loop/switch region; other site 714359004608 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 714359004609 active site 714359004610 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 714359004611 active site 714359004612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359004613 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 714359004614 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 714359004615 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 714359004616 inhibitor-cofactor binding pocket; inhibition site 714359004617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359004618 catalytic residue [active] 714359004619 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 714359004620 trimer interface [polypeptide binding]; other site 714359004621 active site 714359004622 substrate binding site [chemical binding]; other site 714359004623 CoA binding site [chemical binding]; other site 714359004624 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 714359004625 putative dimer interface [polypeptide binding]; other site 714359004626 catalytic triad [active] 714359004627 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 714359004628 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 714359004629 dimer interface [polypeptide binding]; other site 714359004630 FMN binding site [chemical binding]; other site 714359004631 Bacterial SH3 domain; Region: SH3_3; cl02551 714359004632 Bacterial SH3 domain; Region: SH3_3; cl02551 714359004633 Bacterial SH3 domain; Region: SH3_3; cl02551 714359004634 NlpC/P60 family; Region: NLPC_P60; cl11438 714359004635 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359004636 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 714359004637 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 714359004638 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359004639 Walker A/P-loop; other site 714359004640 ATP binding site [chemical binding]; other site 714359004641 Q-loop/lid; other site 714359004642 ABC transporter signature motif; other site 714359004643 Walker B; other site 714359004644 D-loop; other site 714359004645 H-loop/switch region; other site 714359004646 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359004647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359004648 active site 714359004649 phosphorylation site [posttranslational modification] 714359004650 intermolecular recognition site; other site 714359004651 dimerization interface [polypeptide binding]; other site 714359004652 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359004653 DNA binding site [nucleotide binding] 714359004654 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359004655 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 714359004656 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359004657 dimer interface [polypeptide binding]; other site 714359004658 phosphorylation site [posttranslational modification] 714359004659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359004660 ATP binding site [chemical binding]; other site 714359004661 Mg2+ binding site [ion binding]; other site 714359004662 G-X-G motif; other site 714359004663 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 714359004664 classical (c) SDRs; Region: SDR_c; cd05233 714359004665 NAD(P) binding site [chemical binding]; other site 714359004666 active site 714359004667 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 714359004668 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 714359004669 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692 714359004670 nudix motif; other site 714359004671 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 714359004672 homoserine dehydrogenase; Provisional; Region: PRK06349 714359004673 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359004674 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 714359004675 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 714359004676 threonine synthase; Reviewed; Region: PRK06721 714359004677 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 714359004678 homodimer interface [polypeptide binding]; other site 714359004679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359004680 catalytic residue [active] 714359004681 homoserine kinase; Provisional; Region: PRK01212 714359004682 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 714359004683 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 714359004684 Protein of unknown function (DUF3111); Region: DUF3111; pfam11308 714359004685 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 714359004686 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359004687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359004688 active site 714359004689 phosphorylation site [posttranslational modification] 714359004690 intermolecular recognition site; other site 714359004691 dimerization interface [polypeptide binding]; other site 714359004692 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359004693 DNA binding site [nucleotide binding] 714359004694 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 714359004695 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359004696 dimer interface [polypeptide binding]; other site 714359004697 phosphorylation site [posttranslational modification] 714359004698 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359004699 ATP binding site [chemical binding]; other site 714359004700 Mg2+ binding site [ion binding]; other site 714359004701 G-X-G motif; other site 714359004702 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 714359004703 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 714359004704 MgtC family; Region: MgtC; cl12207 714359004705 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 714359004706 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359004707 Coenzyme A binding pocket [chemical binding]; other site 714359004708 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 714359004709 IucA / IucC family; Region: IucA_IucC; pfam04183 714359004710 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 714359004711 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 714359004712 IucA / IucC family; Region: IucA_IucC; pfam04183 714359004713 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 714359004714 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359004715 Phosphopantetheine attachment site; Region: PP-binding; cl09936 714359004716 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 714359004717 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 714359004718 AP (apurinic/apyrimidinic) site pocket; other site 714359004719 DNA interaction; other site 714359004720 Metal-binding active site; metal-binding site 714359004721 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 714359004722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359004723 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359004724 putative substrate translocation pore; other site 714359004725 LysE type translocator; Region: LysE; cl00565 714359004726 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 714359004727 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359004728 DNA-binding site [nucleotide binding]; DNA binding site 714359004729 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714359004730 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359004731 homodimer interface [polypeptide binding]; other site 714359004732 catalytic residue [active] 714359004733 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 714359004734 active site 714359004735 nucleophile elbow; other site 714359004736 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 714359004737 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279 714359004738 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 714359004739 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 714359004740 nudix motif; other site 714359004741 NAD+ synthetase; Region: nadE; TIGR00552 714359004742 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 714359004743 homodimer interface [polypeptide binding]; other site 714359004744 NAD binding pocket [chemical binding]; other site 714359004745 ATP binding pocket [chemical binding]; other site 714359004746 Mg binding site [ion binding]; other site 714359004747 active-site loop [active] 714359004748 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 714359004749 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 714359004750 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 714359004751 active site 714359004752 catalytic residues [active] 714359004753 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359004754 dimerization interface [polypeptide binding]; other site 714359004755 putative DNA binding site [nucleotide binding]; other site 714359004756 putative Zn2+ binding site [ion binding]; other site 714359004757 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 714359004758 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 714359004759 active site 714359004760 catalytic tetrad [active] 714359004761 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 714359004762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359004763 putative substrate translocation pore; other site 714359004764 Protein of unknown function (DUF805); Region: DUF805; cl01224 714359004765 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs...; Region: YjeQ_engC; cd01854 714359004766 GTP/Mg2+ binding site [chemical binding]; other site 714359004767 G4 box; other site 714359004768 G5 box; other site 714359004769 G1 box; other site 714359004770 Switch I region; other site 714359004771 G2 box; other site 714359004772 G3 box; other site 714359004773 Switch II region; other site 714359004774 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These transmembrane...; Region: TarH; cl00144 714359004775 Cache domain; Region: Cache_1; pfam02743 714359004776 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 714359004777 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359004778 dimerization interface [polypeptide binding]; other site 714359004779 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 714359004780 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These transmembrane...; Region: TarH; cl00144 714359004781 Uncharacterized membrane protein [Function unknown]; Region: COG3949 714359004782 Ferritin-like domain; Region: Ferritin; pfam00210 714359004783 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 714359004784 dimerization interface [polypeptide binding]; other site 714359004785 DPS ferroxidase diiron center [ion binding]; other site 714359004786 ion pore; other site 714359004787 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 714359004788 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 714359004789 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 714359004790 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 714359004791 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359004792 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714359004793 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359004794 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 714359004795 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 714359004796 active site 714359004797 catalytic tetrad [active] 714359004798 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 714359004799 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 714359004800 P-loop, Walker A motif; other site 714359004801 Base recognition motif; other site 714359004802 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 714359004803 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359004804 Coenzyme A binding pocket [chemical binding]; other site 714359004805 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 714359004806 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 714359004807 metal binding site [ion binding]; metal-binding site 714359004808 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 714359004809 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 714359004810 NAD binding site [chemical binding]; other site 714359004811 active site 714359004812 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 714359004813 active site 714359004814 FMN binding site [chemical binding]; other site 714359004815 substrate binding site [chemical binding]; other site 714359004816 homotetramer interface [polypeptide binding]; other site 714359004817 catalytic residue [active] 714359004818 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 714359004819 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 714359004820 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 714359004821 DNA binding site [nucleotide binding] 714359004822 active site 714359004823 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 714359004824 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 714359004825 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 714359004826 peptide binding site [polypeptide binding]; other site 714359004827 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359004828 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 714359004829 active site 714359004830 metal binding site [ion binding]; metal-binding site 714359004831 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359004832 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 714359004833 catalytic core [active] 714359004834 CotH protein; Region: CotH; pfam08757 714359004835 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 714359004836 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 714359004837 nudix motif; other site 714359004838 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 714359004839 MatE; Region: MatE; cl10513 714359004840 MviN-like protein; Region: MVIN; pfam03023 714359004841 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 714359004842 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 714359004843 Predicted permease; Region: DUF318; cl00487 714359004844 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 714359004845 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 714359004846 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 714359004847 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 714359004848 putative active site [active] 714359004849 catalytic site [active] 714359004850 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 714359004851 putative active site [active] 714359004852 catalytic site [active] 714359004853 Coat F domain; Region: Coat_F; cl02368 714359004854 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 714359004855 NAD binding site [chemical binding]; other site 714359004856 substrate binding site [chemical binding]; other site 714359004857 putative active site [active] 714359004858 Protein of unknown function (DUF456); Region: DUF456; cl01069 714359004859 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 714359004860 Domain of unknown function DUF21; Region: DUF21; pfam01595 714359004861 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 714359004862 Transporter associated domain; Region: CorC_HlyC; cl08393 714359004863 FOG: CBS domain [General function prediction only]; Region: COG0517 714359004864 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 714359004865 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 714359004866 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 714359004867 dimer interface [polypeptide binding]; other site 714359004868 putative tRNA-binding site [nucleotide binding]; other site 714359004869 DinB superfamily; Region: DinB_2; cl00986 714359004870 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 714359004871 stage II sporulation protein P; Region: spore_II_P; TIGR02867 714359004872 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359004873 Coenzyme A binding pocket [chemical binding]; other site 714359004874 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359004875 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 714359004876 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 714359004877 nudix motif; other site 714359004878 amidase; Provisional; Region: PRK06828 714359004879 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 714359004880 H+ Antiporter protein; Region: 2A0121; TIGR00900 714359004881 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359004882 putative substrate translocation pore; other site 714359004883 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 714359004884 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 714359004885 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 714359004886 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 714359004887 stage II sporulation protein P; Region: spore_II_P; TIGR02867 714359004888 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 714359004889 catalytic core [active] 714359004890 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359004891 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 714359004892 active site 714359004893 motif I; other site 714359004894 motif II; other site 714359004895 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359004896 multidrug resistance protein MdtH; Provisional; Region: PRK11646 714359004897 DinB superfamily; Region: DinB_2; cl00986 714359004898 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 714359004899 alanine racemase; Reviewed; Region: alr; PRK00053 714359004900 active site 714359004901 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 714359004902 dimer interface [polypeptide binding]; other site 714359004903 substrate binding site [chemical binding]; other site 714359004904 catalytic residues [active] 714359004905 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359004906 Coenzyme A binding pocket [chemical binding]; other site 714359004907 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359004908 Coenzyme A binding pocket [chemical binding]; other site 714359004909 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 714359004910 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 714359004911 glycosyltransferase, MGT family; Region: MGT; TIGR01426 714359004912 active site 714359004913 TDP-binding site; other site 714359004914 acceptor substrate-binding pocket; other site 714359004915 homodimer interface [polypeptide binding]; other site 714359004916 Uncharacterized conserved protein [Function unknown]; Region: COG1284 714359004917 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 714359004918 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 714359004919 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 714359004920 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359004921 DNA-binding site [nucleotide binding]; DNA binding site 714359004922 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714359004923 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359004924 homodimer interface [polypeptide binding]; other site 714359004925 catalytic residue [active] 714359004926 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359004927 Coenzyme A binding pocket [chemical binding]; other site 714359004928 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 714359004929 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 714359004930 active site 714359004931 metal binding site [ion binding]; metal-binding site 714359004932 Protein of unknown function (DUF1648); Region: DUF1648; cl01712 714359004933 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714359004934 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359004935 hypothetical protein; Provisional; Region: PRK13679 714359004936 putative acetyltransferase; Provisional; Region: PRK03624 714359004937 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359004938 Coenzyme A binding pocket [chemical binding]; other site 714359004939 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359004940 Coenzyme A binding pocket [chemical binding]; other site 714359004941 Proteins of 100 residues with WXG; Region: WXG100; cl02005 714359004942 Firmicute eSAT-6 protein secretion system EssA; Region: EssA; cl11266 714359004943 YukD; Region: YukD; cl11566 714359004944 Predicted membrane protein essB; Region: essB; cl01868 714359004945 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 714359004946 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 714359004947 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359004948 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359004949 Bacillus transposase protein; Region: Transposase_30; pfam04740 714359004950 Predicted acetyltransferase [General function prediction only]; Region: COG3393 714359004951 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359004952 Coenzyme A binding pocket [chemical binding]; other site 714359004953 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 714359004954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359004955 S-adenosylmethionine binding site [chemical binding]; other site 714359004956 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 714359004957 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 714359004958 Potassium binding sites [ion binding]; other site 714359004959 Cesium cation binding sites [ion binding]; other site 714359004960 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 714359004961 DEAD-like helicases superfamily; Region: DEXDc; smart00487 714359004962 ATP binding site [chemical binding]; other site 714359004963 Mg++ binding site [ion binding]; other site 714359004964 motif III; other site 714359004965 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714359004966 nucleotide binding region [chemical binding]; other site 714359004967 ATP-binding site [chemical binding]; other site 714359004968 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 714359004969 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359004970 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 714359004971 RNA polymerase sigma factor; Provisional; Region: PRK12543 714359004972 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359004973 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714359004974 DNA binding residues [nucleotide binding] 714359004975 Domain of unknown function (DUF3600); Region: DUF3600; pfam12207 714359004976 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 714359004977 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 714359004978 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 714359004979 catalytic residues [active] 714359004980 dimer interface [polypeptide binding]; other site 714359004981 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 714359004982 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 714359004983 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 714359004984 MoxR-like ATPases [General function prediction only]; Region: COG0714 714359004985 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359004986 Walker A motif; other site 714359004987 ATP binding site [chemical binding]; other site 714359004988 Walker B motif; other site 714359004989 arginine finger; other site 714359004990 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359004991 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 714359004992 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 714359004993 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 714359004994 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 714359004995 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 714359004996 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 714359004997 molybdopterin cofactor binding site; other site 714359004998 nitrate reductase, beta subunit; Region: narH; TIGR01660 714359004999 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 714359005000 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 714359005001 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 714359005002 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 714359005003 ligand binding site [chemical binding]; other site 714359005004 flexible hinge region; other site 714359005005 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 714359005006 putative switch regulator; other site 714359005007 non-specific DNA interactions [nucleotide binding]; other site 714359005008 DNA binding site [nucleotide binding] 714359005009 sequence specific DNA binding site [nucleotide binding]; other site 714359005010 putative cAMP binding site [chemical binding]; other site 714359005011 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 714359005012 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359005013 FeS/SAM binding site; other site 714359005014 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 714359005015 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 714359005016 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 714359005017 ATP binding site [chemical binding]; other site 714359005018 substrate interface [chemical binding]; other site 714359005019 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 714359005020 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 714359005021 dimer interface [polypeptide binding]; other site 714359005022 putative functional site; other site 714359005023 putative MPT binding site; other site 714359005024 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 714359005025 MoaE homodimer interface [polypeptide binding]; other site 714359005026 MoaD interaction [polypeptide binding]; other site 714359005027 active site residues [active] 714359005028 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 714359005029 MoaE interaction surface [polypeptide binding]; other site 714359005030 MoeB interaction surface [polypeptide binding]; other site 714359005031 thiocarboxylated glycine; other site 714359005032 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 714359005033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359005034 putative substrate translocation pore; other site 714359005035 Membrane transport protein; Region: Mem_trans; cl09117 714359005036 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 714359005037 putative active site [active] 714359005038 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 714359005039 putative active site [active] 714359005040 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 714359005041 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 714359005042 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 714359005043 [2Fe-2S] cluster binding site [ion binding]; other site 714359005044 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 714359005045 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359005046 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 714359005047 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 714359005048 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 714359005049 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 714359005050 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 714359005051 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl11605 714359005052 N-acetyltransferase; Region: Acetyltransf_2; cl00949 714359005053 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 714359005054 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 714359005055 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 714359005056 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 714359005057 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 714359005058 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 714359005059 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 714359005060 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359005061 Walker A/P-loop; other site 714359005062 ATP binding site [chemical binding]; other site 714359005063 Q-loop/lid; other site 714359005064 ABC transporter signature motif; other site 714359005065 Walker B; other site 714359005066 D-loop; other site 714359005067 H-loop/switch region; other site 714359005068 ABC transporter; Region: ABC_tran_2; pfam12848 714359005069 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 714359005070 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 714359005071 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 714359005072 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 714359005073 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 714359005074 Protein of unknown function, DUF393; Region: DUF393; cl01136 714359005075 Protein of unknown function (DUF1094); Region: DUF1094; pfam06491 714359005076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 714359005077 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 714359005078 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 714359005079 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 714359005080 active site 714359005081 HIGH motif; other site 714359005082 KMSK motif region; other site 714359005083 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 714359005084 tRNA binding surface [nucleotide binding]; other site 714359005085 anticodon binding site; other site 714359005086 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 714359005087 putative catalytic site [active] 714359005088 putative phosphate binding site [ion binding]; other site 714359005089 putative metal binding site [ion binding]; other site 714359005090 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 714359005091 putative active site [active] 714359005092 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359005093 binding surface 714359005094 TPR motif; other site 714359005095 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359005096 binding surface 714359005097 TPR motif; other site 714359005098 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359005099 binding surface 714359005100 TPR motif; other site 714359005101 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 714359005102 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359005103 binding surface 714359005104 TPR motif; other site 714359005105 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359005106 binding surface 714359005107 TPR motif; other site 714359005108 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359005109 binding surface 714359005110 TPR motif; other site 714359005111 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 714359005112 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 714359005113 HIGH motif; other site 714359005114 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 714359005115 active site 714359005116 KMSKS motif; other site 714359005117 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 714359005118 tRNA binding surface [nucleotide binding]; other site 714359005119 anticodon binding site; other site 714359005120 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 714359005121 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 714359005122 Peptidase propeptide and YPEB domain; Region: PepSY; cl15480 714359005123 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 714359005124 Zn binding site [ion binding]; other site 714359005125 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 714359005126 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 714359005127 Dimer interface [polypeptide binding]; other site 714359005128 anticodon binding site; other site 714359005129 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 714359005130 homodimer interface [polypeptide binding]; other site 714359005131 motif 1; other site 714359005132 motif 2; other site 714359005133 active site 714359005134 motif 3; other site 714359005135 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 714359005136 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359005137 Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435 714359005138 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 714359005139 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 714359005140 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359005141 motif II; other site 714359005142 Citrate transporter; Region: CitMHS; pfam03600 714359005143 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 714359005144 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 714359005145 putative active site [active] 714359005146 metal binding site [ion binding]; metal-binding site 714359005147 aspartate racemase; Region: asp_race; TIGR00035 714359005148 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 714359005149 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 714359005150 homodimer interaction site [polypeptide binding]; other site 714359005151 cofactor binding site; other site 714359005152 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359005153 Coenzyme A binding pocket [chemical binding]; other site 714359005154 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359005155 hypothetical protein; Validated; Region: PRK06769 714359005156 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359005157 active site 714359005158 motif I; other site 714359005159 motif II; other site 714359005160 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 714359005161 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359005162 Coenzyme A binding pocket [chemical binding]; other site 714359005163 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 714359005164 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 714359005165 Walker A/P-loop; other site 714359005166 ATP binding site [chemical binding]; other site 714359005167 Q-loop/lid; other site 714359005168 ABC transporter signature motif; other site 714359005169 Walker B; other site 714359005170 D-loop; other site 714359005171 H-loop/switch region; other site 714359005172 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 714359005173 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 714359005174 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359005175 motif II; other site 714359005176 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 714359005177 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359005178 active site 714359005179 metal binding site [ion binding]; metal-binding site 714359005180 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 714359005181 Phosphotransferase enzyme family; Region: APH; pfam01636 714359005182 active site 714359005183 substrate binding site [chemical binding]; other site 714359005184 ATP binding site [chemical binding]; other site 714359005185 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359005186 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 714359005187 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 714359005188 dimerization interface [polypeptide binding]; other site 714359005189 active site 714359005190 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 714359005191 folate binding site [chemical binding]; other site 714359005192 NADP+ binding site [chemical binding]; other site 714359005193 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 714359005194 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 714359005195 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 714359005196 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359005197 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 714359005198 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 714359005199 putative acyl-acceptor binding pocket; other site 714359005200 Haemolysin-III related; Region: HlyIII; cl03831 714359005201 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 714359005202 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 714359005203 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 714359005204 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 714359005205 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 714359005206 Cu(I) binding site [ion binding]; other site 714359005207 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 714359005208 putative dimer interface [polypeptide binding]; other site 714359005209 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 714359005210 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 714359005211 active site 714359005212 dimer interface [polypeptide binding]; other site 714359005213 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 714359005214 Ligand Binding Site [chemical binding]; other site 714359005215 Molecular Tunnel; other site 714359005216 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359005217 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 714359005218 active site 714359005219 metal binding site [ion binding]; metal-binding site 714359005220 Bacterial SH3 domain; Region: SH3_3; cl02551 714359005221 Bacterial SH3 domain; Region: SH3_3; cl02551 714359005222 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 714359005223 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 714359005224 siderophore binding site; other site 714359005225 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 714359005226 homodimer interface [polypeptide binding]; other site 714359005227 substrate-cofactor binding pocket; other site 714359005228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359005229 Aminotransferase class IV; Region: Aminotran_4; pfam01063 714359005230 catalytic residue [active] 714359005231 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 714359005232 FMN binding site [chemical binding]; other site 714359005233 dimer interface [polypeptide binding]; other site 714359005234 Isochorismatase family; Region: Isochorismatase; pfam00857 714359005235 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 714359005236 catalytic triad [active] 714359005237 conserved cis-peptide bond; other site 714359005238 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 714359005239 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 714359005240 putative dimer interface [polypeptide binding]; other site 714359005241 Mechanosensitive ion channel; Region: MS_channel; pfam00924 714359005242 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 714359005243 GAF domain; Region: GAF; cl00853 714359005244 Histidine kinase; Region: HisKA_3; pfam07730 714359005245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359005246 ATP binding site [chemical binding]; other site 714359005247 Mg2+ binding site [ion binding]; other site 714359005248 G-X-G motif; other site 714359005249 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359005250 active site 714359005251 phosphorylation site [posttranslational modification] 714359005252 intermolecular recognition site; other site 714359005253 dimerization interface [polypeptide binding]; other site 714359005254 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714359005255 DNA binding residues [nucleotide binding] 714359005256 dimerization interface [polypeptide binding]; other site 714359005257 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 714359005258 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 714359005259 putative active site [active] 714359005260 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 714359005261 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 714359005262 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 714359005263 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 714359005264 NAD binding site [chemical binding]; other site 714359005265 substrate binding site [chemical binding]; other site 714359005266 catalytic Zn binding site [ion binding]; other site 714359005267 tetramer interface [polypeptide binding]; other site 714359005268 structural Zn binding site [ion binding]; other site 714359005269 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 714359005270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359005271 dimer interface [polypeptide binding]; other site 714359005272 conserved gate region; other site 714359005273 ABC-ATPase subunit interface; other site 714359005274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 714359005275 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 714359005276 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 714359005277 N- and C-terminal domain interface [polypeptide binding]; other site 714359005278 putative active site [active] 714359005279 catalytic site [active] 714359005280 metal binding site [ion binding]; metal-binding site 714359005281 carbohydrate binding site [chemical binding]; other site 714359005282 ATP binding site [chemical binding]; other site 714359005283 gluconate transporter; Region: gntP; TIGR00791 714359005284 GntP family permease; Region: GntP_permease; cl15264 714359005285 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 714359005286 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359005287 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 714359005288 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 714359005289 active site 714359005290 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 714359005291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359005292 H+ Antiporter protein; Region: 2A0121; TIGR00900 714359005293 putative substrate translocation pore; other site 714359005294 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 714359005295 putative active site [active] 714359005296 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 714359005297 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 714359005298 Walker A/P-loop; other site 714359005299 ATP binding site [chemical binding]; other site 714359005300 Q-loop/lid; other site 714359005301 ABC transporter signature motif; other site 714359005302 Walker B; other site 714359005303 D-loop; other site 714359005304 H-loop/switch region; other site 714359005305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 714359005306 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 714359005307 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 714359005308 Amino acid permease; Region: AA_permease; cl00524 714359005309 MoxR-like ATPases [General function prediction only]; Region: COG0714 714359005310 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 714359005311 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 714359005312 Hemagglutinin; Region: Hemagglutinin; pfam00509 714359005313 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 714359005314 Domain of unknown function DUF21; Region: DUF21; pfam01595 714359005315 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 714359005316 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 714359005317 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 714359005318 NAD(P) binding site [chemical binding]; other site 714359005319 catalytic residues [active] 714359005320 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 714359005321 Histidine kinase N terminal; Region: HisK_N; pfam09385 714359005322 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359005323 dimer interface [polypeptide binding]; other site 714359005324 phosphorylation site [posttranslational modification] 714359005325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359005326 ATP binding site [chemical binding]; other site 714359005327 Mg2+ binding site [ion binding]; other site 714359005328 G-X-G motif; other site 714359005329 hypothetical protein; Provisional; Region: PRK06917 714359005330 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 714359005331 inhibitor-cofactor binding pocket; inhibition site 714359005332 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359005333 catalytic residue [active] 714359005334 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 714359005335 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 714359005336 acetylornithine deacetylase; Validated; Region: PRK06915 714359005337 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 714359005338 metal binding site [ion binding]; metal-binding site 714359005339 dimer interface [polypeptide binding]; other site 714359005340 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 714359005341 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359005342 Coenzyme A binding pocket [chemical binding]; other site 714359005343 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 714359005344 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359005345 Walker A motif; other site 714359005346 ATP binding site [chemical binding]; other site 714359005347 Walker B motif; other site 714359005348 arginine finger; other site 714359005349 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359005350 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 714359005351 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359005352 FeS/SAM binding site; other site 714359005353 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 714359005354 uncharacterized protein, YokU family; Region: YokU_near_AblA; TIGR03829 714359005355 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 714359005356 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 714359005357 Catalytic domain of Protein Kinases; Region: PKc; cd00180 714359005358 active site 714359005359 ATP binding site [chemical binding]; other site 714359005360 substrate binding site [chemical binding]; other site 714359005361 activation loop (A-loop); other site 714359005362 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 714359005363 SpoOM protein; Region: Spo0M; pfam07070 714359005364 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 714359005365 active site 714359005366 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 714359005367 Cation efflux family; Region: Cation_efflux; cl00316 714359005368 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 714359005369 catalytic residues [active] 714359005370 Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal...; Region: TNF; cl00147 714359005371 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 714359005372 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 714359005373 active site 714359005374 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 714359005375 PPIC-type PPIASE domain; Region: Rotamase; cl08278 714359005376 YolD-like protein; Region: YolD; pfam08863 714359005377 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 714359005378 classical (c) SDRs; Region: SDR_c; cd05233 714359005379 NAD(P) binding site [chemical binding]; other site 714359005380 active site 714359005381 Proteolipid membrane potential modulator; Region: Pmp3; cl00431 714359005382 Transglycosylase; Region: Transgly; cl07896 714359005383 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 714359005384 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359005385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359005386 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359005387 putative substrate translocation pore; other site 714359005388 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 714359005389 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 714359005390 dimer interface [polypeptide binding]; other site 714359005391 Citrate synthase; Region: Citrate_synt; pfam00285 714359005392 active site 714359005393 coenzyme A binding site [chemical binding]; other site 714359005394 citrylCoA binding site [chemical binding]; other site 714359005395 oxalacetate/citrate binding site [chemical binding]; other site 714359005396 catalytic triad [active] 714359005397 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 714359005398 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 714359005399 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 714359005400 tetramer interface [polypeptide binding]; other site 714359005401 active site 714359005402 Mg2+/Mn2+ binding site [ion binding]; other site 714359005403 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 714359005404 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 714359005405 active site 714359005406 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 714359005407 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359005408 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 714359005409 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 714359005410 tetrameric interface [polypeptide binding]; other site 714359005411 NAD binding site [chemical binding]; other site 714359005412 catalytic residues [active] 714359005413 LysE type translocator; Region: LysE; cl00565 714359005414 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 714359005415 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 714359005416 substrate binding site [chemical binding]; other site 714359005417 oxyanion hole (OAH) forming residues; other site 714359005418 trimer interface [polypeptide binding]; other site 714359005419 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 714359005420 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 714359005421 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 714359005422 active site 714359005423 metal binding site [ion binding]; metal-binding site 714359005424 DNA binding site [nucleotide binding] 714359005425 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 714359005426 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 714359005427 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 714359005428 Walker A/P-loop; other site 714359005429 ATP binding site [chemical binding]; other site 714359005430 Q-loop/lid; other site 714359005431 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 714359005432 ABC transporter signature motif; other site 714359005433 Walker B; other site 714359005434 D-loop; other site 714359005435 H-loop/switch region; other site 714359005436 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359005437 dimerization interface [polypeptide binding]; other site 714359005438 putative DNA binding site [nucleotide binding]; other site 714359005439 putative Zn2+ binding site [ion binding]; other site 714359005440 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 714359005441 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 714359005442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 714359005443 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 714359005444 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 714359005445 putative NAD(P) binding site [chemical binding]; other site 714359005446 active site 714359005447 isochorismate synthase DhbC; Validated; Region: PRK06923 714359005448 chorismate binding enzyme; Region: Chorismate_bind; cl10555 714359005449 2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275 714359005450 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359005451 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359005452 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 714359005453 hydrophobic substrate binding pocket; other site 714359005454 Isochorismatase family; Region: Isochorismatase; pfam00857 714359005455 active site 714359005456 conserved cis-peptide bond; other site 714359005457 Phosphopantetheine attachment site; Region: PP-binding; cl09936 714359005458 peptide synthase; Provisional; Region: PRK12316 714359005459 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359005460 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359005461 Phosphopantetheine attachment site; Region: PP-binding; cl09936 714359005462 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 714359005463 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359005464 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359005465 Phosphopantetheine attachment site; Region: PP-binding; cl09936 714359005466 MbtH-like protein; Region: MbtH; cl01279 714359005467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359005468 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359005469 putative substrate translocation pore; other site 714359005470 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 714359005471 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 714359005472 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 714359005473 IHF dimer interface [polypeptide binding]; other site 714359005474 IHF - DNA interface [nucleotide binding]; other site 714359005475 amidase; Validated; Region: PRK06565 714359005476 DinB superfamily; Region: DinB_2; cl00986 714359005477 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 714359005478 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 714359005479 active site 714359005480 catalytic triad [active] 714359005481 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 714359005482 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 714359005483 metal binding triad [ion binding]; metal-binding site 714359005484 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 714359005485 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 714359005486 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714359005487 RNA binding surface [nucleotide binding]; other site 714359005488 PseudoU_synth_RluF_like: Pseudouridine synthase, Escherichia coli RluF like. This group is comprised of bacterial proteins similar to Escherichia coli RluF. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluF; cd02554 714359005489 probable active site [active] 714359005490 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 714359005491 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 714359005492 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 714359005493 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 714359005494 active site 714359005495 dimer interface [polypeptide binding]; other site 714359005496 motif 1; other site 714359005497 motif 2; other site 714359005498 motif 3; other site 714359005499 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 714359005500 anticodon binding site; other site 714359005501 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 714359005502 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 714359005503 Walker A/P-loop; other site 714359005504 ATP binding site [chemical binding]; other site 714359005505 Q-loop/lid; other site 714359005506 ABC transporter signature motif; other site 714359005507 Walker B; other site 714359005508 D-loop; other site 714359005509 H-loop/switch region; other site 714359005510 FtsX-like permease family; Region: FtsX; pfam02687 714359005511 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 714359005512 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 714359005513 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 714359005514 active site 714359005515 dimerization interface [polypeptide binding]; other site 714359005516 Protein of unknown function (DUF2441); Region: DUF2441; pfam10386 714359005517 Protein of unknown function, DUF606; Region: DUF606; cl01273 714359005518 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 714359005519 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 714359005520 ligand binding site [chemical binding]; other site 714359005521 flexible hinge region; other site 714359005522 Protein of unknown function, DUF606; Region: DUF606; cl01273 714359005523 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 714359005524 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359005525 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359005526 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 714359005527 Probable transposase; Region: OrfB_IS605; pfam01385 714359005528 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 714359005529 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 714359005530 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 714359005531 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359005532 Coenzyme A binding pocket [chemical binding]; other site 714359005533 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 714359005534 putative acetyltransferase YhhY; Provisional; Region: PRK10140 714359005535 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359005536 Coenzyme A binding pocket [chemical binding]; other site 714359005537 EamA-like transporter family; Region: EamA; cl01037 714359005538 EamA-like transporter family; Region: EamA; cl01037 714359005539 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 714359005540 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359005541 non-specific DNA binding site [nucleotide binding]; other site 714359005542 salt bridge; other site 714359005543 sequence-specific DNA binding site [nucleotide binding]; other site 714359005544 Cupin domain; Region: Cupin_2; cl09118 714359005545 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 714359005546 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359005547 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 714359005548 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714359005549 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359005550 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 714359005551 DNA-binding site [nucleotide binding]; DNA binding site 714359005552 RNA-binding motif; other site 714359005553 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 714359005554 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359005555 active site 714359005556 hypothetical protein; Provisional; Region: PRK06770 714359005557 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714359005558 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359005559 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 714359005560 dimerization interface [polypeptide binding]; other site 714359005561 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06728 714359005562 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359005563 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 714359005564 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 714359005565 active site 714359005566 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 714359005567 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 714359005568 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 714359005569 dimerization interface [polypeptide binding]; other site 714359005570 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 714359005571 MOSC domain; Region: MOSC; pfam03473 714359005572 3-alpha domain; Region: 3-alpha; pfam03475 714359005573 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359005574 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 714359005575 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 714359005576 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359005577 Walker A/P-loop; other site 714359005578 ATP binding site [chemical binding]; other site 714359005579 Q-loop/lid; other site 714359005580 ABC transporter signature motif; other site 714359005581 Walker B; other site 714359005582 D-loop; other site 714359005583 H-loop/switch region; other site 714359005584 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 714359005585 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 714359005586 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 714359005587 Walker A/P-loop; other site 714359005588 ATP binding site [chemical binding]; other site 714359005589 Q-loop/lid; other site 714359005590 ABC transporter signature motif; other site 714359005591 Walker B; other site 714359005592 D-loop; other site 714359005593 H-loop/switch region; other site 714359005594 LysE type translocator; Region: LysE; cl00565 714359005595 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 714359005596 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359005597 non-specific DNA binding site [nucleotide binding]; other site 714359005598 salt bridge; other site 714359005599 sequence-specific DNA binding site [nucleotide binding]; other site 714359005600 Cupin domain; Region: Cupin_2; cl09118 714359005601 BclB C-terminal domain; Region: exospore_TM; TIGR03721 714359005602 Cupin domain; Region: Cupin_2; cl09118 714359005603 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 714359005604 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359005605 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359005606 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 714359005607 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359005608 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 714359005609 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359005610 S-adenosylmethionine binding site [chemical binding]; other site 714359005611 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 714359005612 Uncharacterised BCR, COG1649; Region: DUF187; cl15398 714359005613 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 714359005614 active site 714359005615 P-loop; other site 714359005616 phosphorylation site [posttranslational modification] 714359005617 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 714359005618 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 714359005619 Uncharacterised protein family (UPF0075); Region: UPF0075; cl04217 714359005620 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 714359005621 Domain of unknown function (DUF205); Region: DUF205; cl00410 714359005622 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 714359005623 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 714359005624 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 714359005625 catalytic residue [active] 714359005626 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 714359005627 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 714359005628 tetramer interface [polypeptide binding]; other site 714359005629 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359005630 catalytic residue [active] 714359005631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359005632 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359005633 putative substrate translocation pore; other site 714359005634 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 714359005635 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 714359005636 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 714359005637 ATP binding site [chemical binding]; other site 714359005638 Mg++ binding site [ion binding]; other site 714359005639 motif III; other site 714359005640 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714359005641 nucleotide binding region [chemical binding]; other site 714359005642 ATP-binding site [chemical binding]; other site 714359005643 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359005644 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359005645 H+ Antiporter protein; Region: 2A0121; TIGR00900 714359005646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 714359005647 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 714359005648 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 714359005649 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 714359005650 Phage integrase family; Region: Phage_integrase; pfam00589 714359005651 Int/Topo IB signature motif; other site 714359005652 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 714359005653 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 714359005654 sugar binding site [chemical binding]; other site 714359005655 Phage tail protein; Region: Sipho_tail; cl11462 714359005656 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 714359005657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359005658 S-adenosylmethionine binding site [chemical binding]; other site 714359005659 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 714359005660 dimer interface [polypeptide binding]; other site 714359005661 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359005662 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 714359005663 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 714359005664 dimer interface [polypeptide binding]; other site 714359005665 PYR/PP interface [polypeptide binding]; other site 714359005666 TPP binding site [chemical binding]; other site 714359005667 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 714359005668 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 714359005669 TPP-binding site [chemical binding]; other site 714359005670 dimer interface [polypeptide binding]; other site 714359005671 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359005672 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 714359005673 catalytic core [active] 714359005674 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 714359005675 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 714359005676 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 714359005677 metal binding site [ion binding]; metal-binding site 714359005678 dimer interface [polypeptide binding]; other site 714359005679 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714359005680 DNA binding residues [nucleotide binding] 714359005681 dimerization interface [polypeptide binding]; other site 714359005682 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359005683 non-specific DNA binding site [nucleotide binding]; other site 714359005684 salt bridge; other site 714359005685 sequence-specific DNA binding site [nucleotide binding]; other site 714359005686 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 714359005687 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 714359005688 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 714359005689 trimer interface [polypeptide binding]; other site 714359005690 active site 714359005691 substrate binding site [chemical binding]; other site 714359005692 CoA binding site [chemical binding]; other site 714359005693 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 714359005694 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 714359005695 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 714359005696 active site 714359005697 catalytic triad [active] 714359005698 oxyanion hole [active] 714359005699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359005700 H+ Antiporter protein; Region: 2A0121; TIGR00900 714359005701 putative substrate translocation pore; other site 714359005702 peptide synthase; Provisional; Region: PRK12467 714359005703 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359005704 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359005705 Phosphopantetheine attachment site; Region: PP-binding; cl09936 714359005706 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 714359005707 peptide synthase; Provisional; Region: PRK12467 714359005708 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359005709 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359005710 Phosphopantetheine attachment site; Region: PP-binding; cl09936 714359005711 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 714359005712 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359005713 Phosphopantetheine attachment site; Region: PP-binding; cl09936 714359005714 peptide synthase; Provisional; Region: PRK12316 714359005715 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359005716 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359005717 Phosphopantetheine attachment site; Region: PP-binding; cl09936 714359005718 peptide synthase; Provisional; Region: PRK12467 714359005719 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359005720 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359005721 Phosphopantetheine attachment site; Region: PP-binding; cl09936 714359005722 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359005723 Phosphopantetheine attachment site; Region: PP-binding; cl09936 714359005724 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 714359005725 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359005726 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359005727 Phosphopantetheine attachment site; Region: PP-binding; cl09936 714359005728 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 714359005729 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 714359005730 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 714359005731 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 714359005732 Erythromycin esterase; Region: Erythro_esteras; pfam05139 714359005733 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 714359005734 N-acetyl-D-glucosamine binding site [chemical binding]; other site 714359005735 catalytic residue [active] 714359005736 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714359005737 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359005738 S-layer homology domain; Region: SLH; pfam00395 714359005739 S-layer homology domain; Region: SLH; pfam00395 714359005740 S-layer homology domain; Region: SLH; pfam00395 714359005741 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 714359005742 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 714359005743 active site 714359005744 nucleophile elbow; other site 714359005745 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 714359005746 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 714359005747 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359005748 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359005749 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 714359005750 Collagenase; Region: Peptidase_M9; pfam01752 714359005751 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 714359005752 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 714359005753 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 714359005754 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 714359005755 Walker A/P-loop; other site 714359005756 ATP binding site [chemical binding]; other site 714359005757 Q-loop/lid; other site 714359005758 ABC transporter signature motif; other site 714359005759 Walker B; other site 714359005760 D-loop; other site 714359005761 H-loop/switch region; other site 714359005762 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359005763 S-layer homology domain; Region: SLH; pfam00395 714359005764 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 714359005765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359005766 active site 714359005767 phosphorylation site [posttranslational modification] 714359005768 intermolecular recognition site; other site 714359005769 dimerization interface [polypeptide binding]; other site 714359005770 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714359005771 DNA binding residues [nucleotide binding] 714359005772 dimerization interface [polypeptide binding]; other site 714359005773 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359005774 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 714359005775 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 714359005776 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 714359005777 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359005778 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 714359005779 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359005780 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714359005781 DNA binding residues [nucleotide binding] 714359005782 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 714359005783 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 714359005784 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359005785 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 714359005786 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 714359005787 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 714359005788 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359005789 beta-lactamase TEM; Provisional; Region: PRK15442 714359005790 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359005791 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 714359005792 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 714359005793 putative active site [active] 714359005794 putative metal binding site [ion binding]; other site 714359005795 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 714359005796 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359005797 Walker A/P-loop; other site 714359005798 ATP binding site [chemical binding]; other site 714359005799 Q-loop/lid; other site 714359005800 ABC transporter signature motif; other site 714359005801 Walker B; other site 714359005802 D-loop; other site 714359005803 H-loop/switch region; other site 714359005804 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 714359005805 ABC-2 type transporter; Region: ABC2_membrane; cl11417 714359005806 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359005807 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359005808 Protein of unknown function (DUF523); Region: DUF523; cl00733 714359005809 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 714359005810 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 714359005811 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 714359005812 FAD binding site [chemical binding]; other site 714359005813 homotetramer interface [polypeptide binding]; other site 714359005814 substrate binding pocket [chemical binding]; other site 714359005815 catalytic base [active] 714359005816 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 714359005817 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 714359005818 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 714359005819 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 714359005820 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 714359005821 carboxyltransferase (CT) interaction site; other site 714359005822 biotinylation site [posttranslational modification]; other site 714359005823 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 714359005824 active site 714359005825 catalytic residues [active] 714359005826 metal binding site [ion binding]; metal-binding site 714359005827 enoyl-CoA hydratase; Provisional; Region: PRK07657 714359005828 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 714359005829 substrate binding site [chemical binding]; other site 714359005830 oxyanion hole (OAH) forming residues; other site 714359005831 trimer interface [polypeptide binding]; other site 714359005832 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 714359005833 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 714359005834 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 714359005835 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 714359005836 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 714359005837 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359005838 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359005839 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359005840 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359005841 active site 714359005842 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359005843 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 714359005844 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359005845 dimer interface [polypeptide binding]; other site 714359005846 phosphorylation site [posttranslational modification] 714359005847 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359005848 ATP binding site [chemical binding]; other site 714359005849 Mg2+ binding site [ion binding]; other site 714359005850 G-X-G motif; other site 714359005851 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359005852 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359005853 active site 714359005854 phosphorylation site [posttranslational modification] 714359005855 intermolecular recognition site; other site 714359005856 dimerization interface [polypeptide binding]; other site 714359005857 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359005858 DNA binding site [nucleotide binding] 714359005859 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 714359005860 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 714359005861 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 714359005862 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359005863 Coenzyme A binding pocket [chemical binding]; other site 714359005864 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 714359005865 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359005866 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 714359005867 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 714359005868 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 714359005869 active site 714359005870 Zn binding site [ion binding]; other site 714359005871 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 714359005872 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 714359005873 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 714359005874 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714359005875 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 714359005876 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359005877 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359005878 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 714359005879 active site 714359005880 catalytic site [active] 714359005881 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 714359005882 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359005883 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359005884 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359005885 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359005886 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 714359005887 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 714359005888 putative hydrophobic ligand binding site [chemical binding]; other site 714359005889 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359005890 Walker A/P-loop; other site 714359005891 ATP binding site [chemical binding]; other site 714359005892 The excision repair protein UvrA; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep ATP-dependent...; Region: ABC_UvrA; cd03238 714359005893 The excision repair protein UvrA; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep ATP-dependent...; Region: ABC_UvrA; cd03238 714359005894 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 714359005895 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 714359005896 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 714359005897 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359005898 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 714359005899 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 714359005900 DNA binding residues [nucleotide binding] 714359005901 drug binding residues [chemical binding]; other site 714359005902 dimer interface [polypeptide binding]; other site 714359005903 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 714359005904 H+ Antiporter protein; Region: 2A0121; TIGR00900 714359005905 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359005906 putative substrate translocation pore; other site 714359005907 classical (c) SDRs; Region: SDR_c; cd05233 714359005908 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 714359005909 NAD(P) binding site [chemical binding]; other site 714359005910 active site 714359005911 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359005912 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 714359005913 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 714359005914 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 714359005915 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359005916 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 714359005917 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 714359005918 active site 714359005919 metal binding site [ion binding]; metal-binding site 714359005920 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714359005921 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359005922 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 714359005923 dimerization interface [polypeptide binding]; other site 714359005924 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 714359005925 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 714359005926 active site 714359005927 Zn binding site [ion binding]; other site 714359005928 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 714359005929 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359005930 DNA-binding site [nucleotide binding]; DNA binding site 714359005931 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714359005932 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359005933 homodimer interface [polypeptide binding]; other site 714359005934 catalytic residue [active] 714359005935 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 714359005936 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 714359005937 Cysteine dioxygenase type I; Region: CDO_I; cl02350 714359005938 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 714359005939 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 714359005940 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 714359005941 putative NAD(P) binding site [chemical binding]; other site 714359005942 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 714359005943 extended (e) SDRs; Region: SDR_e; cd08946 714359005944 NAD(P) binding site [chemical binding]; other site 714359005945 active site 714359005946 substrate binding site [chemical binding]; other site 714359005947 Protein of unknown function (DUF421); Region: DUF421; cl00990 714359005948 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359005949 S-adenosylmethionine binding site [chemical binding]; other site 714359005950 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359005951 S-adenosylmethionine binding site [chemical binding]; other site 714359005952 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 714359005953 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 714359005954 catalytic core domain of class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674 714359005955 active site 714359005956 HIGH motif; other site 714359005957 KMSKS motif; other site 714359005958 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 714359005959 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359005960 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359005961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359005962 active site 714359005963 phosphorylation site [posttranslational modification] 714359005964 intermolecular recognition site; other site 714359005965 dimerization interface [polypeptide binding]; other site 714359005966 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359005967 DNA binding site [nucleotide binding] 714359005968 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359005969 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 714359005970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359005971 ATP binding site [chemical binding]; other site 714359005972 Mg2+ binding site [ion binding]; other site 714359005973 G-X-G motif; other site 714359005974 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 714359005975 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 714359005976 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 714359005977 ABC transporter; Region: ABC_tran_2; pfam12848 714359005978 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 714359005979 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714359005980 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 714359005981 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 714359005982 Walker A/P-loop; other site 714359005983 ATP binding site [chemical binding]; other site 714359005984 Q-loop/lid; other site 714359005985 ABC transporter signature motif; other site 714359005986 Walker B; other site 714359005987 D-loop; other site 714359005988 H-loop/switch region; other site 714359005989 FtsX-like permease family; Region: FtsX; pfam02687 714359005990 hypothetical protein; Provisional; Region: PRK06760; cl11698 714359005991 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 714359005992 homoserine dehydrogenase; Validated; Region: PRK06813 714359005993 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 714359005994 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 714359005995 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359005996 DNA-binding site [nucleotide binding]; DNA binding site 714359005997 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714359005998 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359005999 homodimer interface [polypeptide binding]; other site 714359006000 catalytic residue [active] 714359006001 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 714359006002 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 714359006003 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 714359006004 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 714359006005 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 714359006006 Phage integrase family; Region: Phage_integrase; pfam00589 714359006007 Int/Topo IB signature motif; other site 714359006008 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 714359006009 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359006010 non-specific DNA binding site [nucleotide binding]; other site 714359006011 salt bridge; other site 714359006012 sequence-specific DNA binding site [nucleotide binding]; other site 714359006013 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 714359006014 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 714359006015 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 714359006016 Sulfotransferase family; Region: Sulfotransfer_2; cl12149 714359006017 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 714359006018 cofactor binding site; other site 714359006019 DNA binding site [nucleotide binding] 714359006020 substrate interaction site [chemical binding]; other site 714359006021 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 714359006022 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 714359006023 Phage integrase family; Region: Phage_integrase; pfam00589 714359006024 Int/Topo IB signature motif; other site 714359006025 Protein of unknown function (DUF421); Region: DUF421; cl00990 714359006026 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 714359006027 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 714359006028 Phage Terminase; Region: Terminase_1; pfam03354 714359006029 Phage-related protein [Function unknown]; Region: COG4695; cl01923 714359006030 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 714359006031 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 714359006032 oligomer interface [polypeptide binding]; other site 714359006033 active site residues [active] 714359006034 Phage capsid family; Region: Phage_capsid; pfam05065 714359006035 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 714359006036 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 714359006037 Phage-related minor tail protein [Function unknown]; Region: COG5280 714359006038 membrane protein P6; Region: PHA01399 714359006039 membrane protein P6; Region: PHA01399 714359006040 Phage tail protein; Region: Sipho_tail; cl11462 714359006041 Phage tail protein; Region: Sipho_tail; cl11462 714359006042 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 714359006043 Holin family; Region: Phage_holin_4; cl01989 714359006044 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 714359006045 amidase catalytic site [active] 714359006046 Zn binding residues [ion binding]; other site 714359006047 substrate binding site [chemical binding]; other site 714359006048 Bacterial SH3 domain; Region: SH3_3; cl02551 714359006049 Bacterial SH3 domain; Region: SH3_3; cl02551 714359006050 Cytochrome P450; Region: p450; cl12078 714359006051 Sulfotransferase family; Region: Sulfotransfer_2; cl12149 714359006052 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 714359006053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 714359006054 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 714359006055 Protein of unknown function; Region: DUF3658; pfam12395 714359006056 Cytochrome P450; Region: p450; cl12078 714359006057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359006058 H+ Antiporter protein; Region: 2A0121; TIGR00900 714359006059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359006060 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 714359006061 trimer interface [polypeptide binding]; other site 714359006062 active site 714359006063 substrate binding site [chemical binding]; other site 714359006064 CoA binding site [chemical binding]; other site 714359006065 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 714359006066 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359006067 Cytochrome P450; Region: p450; cl12078 714359006068 Cysteine dioxygenase type I; Region: CDO_I; cl02350 714359006069 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359006070 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 714359006071 active site 714359006072 motif I; other site 714359006073 motif II; other site 714359006074 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 714359006075 PAS domain S-box; Region: sensory_box; TIGR00229 714359006076 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 714359006077 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 714359006078 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359006079 dimer interface [polypeptide binding]; other site 714359006080 phosphorylation site [posttranslational modification] 714359006081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359006082 ATP binding site [chemical binding]; other site 714359006083 Mg2+ binding site [ion binding]; other site 714359006084 G-X-G motif; other site 714359006085 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 714359006086 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 714359006087 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 714359006088 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359006089 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 714359006090 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 714359006091 Catalytic site [active] 714359006092 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 714359006093 glycosyltransferase, MGT family; Region: MGT; TIGR01426 714359006094 active site 714359006095 TDP-binding site; other site 714359006096 acceptor substrate-binding pocket; other site 714359006097 homodimer interface [polypeptide binding]; other site 714359006098 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 714359006099 aspartate racemase; Region: asp_race; TIGR00035 714359006100 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 714359006101 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 714359006102 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 714359006103 Walker A/P-loop; other site 714359006104 ATP binding site [chemical binding]; other site 714359006105 Q-loop/lid; other site 714359006106 ABC transporter signature motif; other site 714359006107 Walker B; other site 714359006108 D-loop; other site 714359006109 H-loop/switch region; other site 714359006110 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 714359006111 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 714359006112 Walker A/P-loop; other site 714359006113 ATP binding site [chemical binding]; other site 714359006114 Q-loop/lid; other site 714359006115 ABC transporter signature motif; other site 714359006116 Walker B; other site 714359006117 D-loop; other site 714359006118 H-loop/switch region; other site 714359006119 Cobalt transport protein; Region: CbiQ; cl00463 714359006120 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 714359006121 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359006122 dimer interface [polypeptide binding]; other site 714359006123 phosphorylation site [posttranslational modification] 714359006124 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359006125 ATP binding site [chemical binding]; other site 714359006126 Mg2+ binding site [ion binding]; other site 714359006127 G-X-G motif; other site 714359006128 Uncharacterised protein family (UPF0157); Region: UPF0157; cl00987 714359006129 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 714359006130 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 714359006131 NAD(P) binding site [chemical binding]; other site 714359006132 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 714359006133 active site 714359006134 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 714359006135 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 714359006136 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359006137 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 714359006138 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 714359006139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359006140 H+ Antiporter protein; Region: 2A0121; TIGR00900 714359006141 putative substrate translocation pore; other site 714359006142 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359006143 VanZ like family; Region: VanZ; cl01971 714359006144 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 714359006145 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 714359006146 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 714359006147 conserved cys residue [active] 714359006148 Predicted transcriptional regulator [Transcription]; Region: COG2378 714359006149 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359006150 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 714359006151 conserved cys residue [active] 714359006152 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 714359006153 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg1; cd04777 714359006154 DNA binding residues [nucleotide binding] 714359006155 putative dimer interface [polypeptide binding]; other site 714359006156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 714359006157 H+ Antiporter protein; Region: 2A0121; TIGR00900 714359006158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359006159 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359006160 Coenzyme A binding pocket [chemical binding]; other site 714359006161 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 714359006162 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 714359006163 active site 714359006164 catalytic site [active] 714359006165 metal binding site [ion binding]; metal-binding site 714359006166 Bacterial SH3 domain; Region: SH3_3; cl02551 714359006167 Bacterial SH3 domain; Region: SH3_3; cl02551 714359006168 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 714359006169 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359006170 DNA-binding site [nucleotide binding]; DNA binding site 714359006171 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714359006172 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359006173 homodimer interface [polypeptide binding]; other site 714359006174 catalytic residue [active] 714359006175 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 714359006176 EamA-like transporter family; Region: EamA; cl01037 714359006177 EamA-like transporter family; Region: EamA; cl01037 714359006178 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 714359006179 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 714359006180 active site 714359006181 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359006182 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 714359006183 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_30; cd04689 714359006184 nudix motif; other site 714359006185 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359006186 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 714359006187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359006188 putative substrate translocation pore; other site 714359006189 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 714359006190 Cadmium resistance transporter; Region: Cad; cl04177 714359006191 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 714359006192 nudix motif; other site 714359006193 DNA polymerase III subunit beta; Validated; Region: PRK06673 714359006194 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 714359006195 putative DNA binding surface [nucleotide binding]; other site 714359006196 dimer interface [polypeptide binding]; other site 714359006197 beta-clamp/clamp loader binding surface; other site 714359006198 beta-clamp/translesion DNA polymerase binding surface; other site 714359006199 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 714359006200 translation initiation factor IF-2; Provisional; Region: PRK14845 714359006201 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 714359006202 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 714359006203 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 714359006204 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 714359006205 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 714359006206 active site 714359006207 nucleophile elbow; other site 714359006208 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 714359006209 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359006210 DinB superfamily; Region: DinB_2; cl00986 714359006211 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359006212 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 714359006213 Bacitracin resistance protein BacA; Region: BacA; cl00858 714359006214 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 714359006215 GIY-YIG motif/motif A; other site 714359006216 active site 714359006217 catalytic site [active] 714359006218 putative DNA binding site [nucleotide binding]; other site 714359006219 metal binding site [ion binding]; metal-binding site 714359006220 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359006221 Coenzyme A binding pocket [chemical binding]; other site 714359006222 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 714359006223 active site 714359006224 ATP binding site [chemical binding]; other site 714359006225 substrate binding site [chemical binding]; other site 714359006226 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 714359006227 nudix motif; other site 714359006228 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 714359006229 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359006230 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359006231 Protein of unknown function (DUF419); Region: DUF419; cl15265 714359006232 N-acetyltransferase; Region: Acetyltransf_2; cl00949 714359006233 MepB protein; Region: MepB; cl01985 714359006234 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 714359006235 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359006236 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359006237 motif II; other site 714359006238 DinB superfamily; Region: DinB_2; cl00986 714359006239 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359006240 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 714359006241 carbohydrate binding site [chemical binding]; other site 714359006242 pullulanase, type I; Region: pulA_typeI; TIGR02104 714359006243 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 714359006244 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 714359006245 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 714359006246 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 714359006247 active site 714359006248 Zn binding site [ion binding]; other site 714359006249 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 714359006250 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 714359006251 active site 714359006252 metal binding site [ion binding]; metal-binding site 714359006253 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 714359006254 DinB superfamily; Region: DinB_2; cl00986 714359006255 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 714359006256 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 714359006257 SecY translocase; Region: SecY; pfam00344 714359006258 EamA-like transporter family; Region: EamA; cl01037 714359006259 EamA-like transporter family; Region: EamA; cl01037 714359006260 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 714359006261 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 714359006262 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 714359006263 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 714359006264 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359006265 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 714359006266 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 714359006267 germination protein YpeB; Region: spore_YpeB; TIGR02889 714359006268 Peptidase propeptide and YPEB domain; Region: PepSY; cl15480 714359006269 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 714359006270 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 714359006271 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 714359006272 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359006273 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 714359006274 Putative cyclase; Region: Cyclase; cl00814 714359006275 kynureninase; Region: kynureninase; TIGR01814 714359006276 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 714359006277 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 714359006278 catalytic residue [active] 714359006279 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359006280 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359006281 Major royal jelly protein; Region: MRJP; pfam03022 714359006282 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 714359006283 GAF domain; Region: GAF; cl00853 714359006284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359006285 Walker A motif; other site 714359006286 ATP binding site [chemical binding]; other site 714359006287 Walker B motif; other site 714359006288 arginine finger; other site 714359006289 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359006290 NIPSNAP; Region: NIPSNAP; pfam07978 714359006291 putative acetyltransferase YhhY; Provisional; Region: PRK10140 714359006292 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359006293 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 714359006294 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359006295 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 714359006296 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359006297 S-adenosylmethionine binding site [chemical binding]; other site 714359006298 Rrf2 family protein; Region: rrf2_super; TIGR00738 714359006299 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359006300 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 714359006301 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 714359006302 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359006303 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359006304 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 714359006305 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 714359006306 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 714359006307 E3 interaction surface; other site 714359006308 lipoyl attachment site [posttranslational modification]; other site 714359006309 e3 binding domain; Region: E3_binding; pfam02817 714359006310 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 714359006311 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 714359006312 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 714359006313 alpha subunit interface [polypeptide binding]; other site 714359006314 TPP binding site [chemical binding]; other site 714359006315 heterodimer interface [polypeptide binding]; other site 714359006316 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 714359006317 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 714359006318 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 714359006319 tetramer interface [polypeptide binding]; other site 714359006320 TPP-binding site [chemical binding]; other site 714359006321 heterodimer interface [polypeptide binding]; other site 714359006322 phosphorylation loop region [posttranslational modification] 714359006323 DinB superfamily; Region: DinB_2; cl00986 714359006324 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 714359006325 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 714359006326 NADP binding site [chemical binding]; other site 714359006327 active site 714359006328 steroid binding site; other site 714359006329 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 714359006330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359006331 dimer interface [polypeptide binding]; other site 714359006332 conserved gate region; other site 714359006333 putative PBP binding loops; other site 714359006334 ABC-ATPase subunit interface; other site 714359006335 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 714359006336 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 714359006337 Walker A/P-loop; other site 714359006338 ATP binding site [chemical binding]; other site 714359006339 Q-loop/lid; other site 714359006340 ABC transporter signature motif; other site 714359006341 Walker B; other site 714359006342 D-loop; other site 714359006343 H-loop/switch region; other site 714359006344 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 714359006345 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 714359006346 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 714359006347 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 714359006348 oligomer interface [polypeptide binding]; other site 714359006349 active site residues [active] 714359006350 RNA polymerase factor sigma-70; Validated; Region: PRK06704 714359006351 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359006352 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 714359006353 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 714359006354 catalytic loop [active] 714359006355 iron binding site [ion binding]; other site 714359006356 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 714359006357 tetramer (dimer of dimers) interface [polypeptide binding]; other site 714359006358 active site 714359006359 dimer interface [polypeptide binding]; other site 714359006360 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359006361 Chitin binding domain; Region: Chitin_bind_3; cl03871 714359006362 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 714359006363 Interdomain contacts; other site 714359006364 Cytokine receptor motif; other site 714359006365 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 714359006366 Interdomain contacts; other site 714359006367 Cytokine receptor motif; other site 714359006368 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 714359006369 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 714359006370 glycosyltransferase, MGT family; Region: MGT; TIGR01426 714359006371 active site 714359006372 TDP-binding site; other site 714359006373 acceptor substrate-binding pocket; other site 714359006374 homodimer interface [polypeptide binding]; other site 714359006375 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 714359006376 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359006377 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359006378 Protein of unknown function (DUF419); Region: DUF419; cl15265 714359006379 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359006380 Coenzyme A binding pocket [chemical binding]; other site 714359006381 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359006382 Coenzyme A binding pocket [chemical binding]; other site 714359006383 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714359006384 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359006385 Coenzyme A binding pocket [chemical binding]; other site 714359006386 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359006387 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 714359006388 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359006389 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 714359006390 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 714359006391 putative active site pocket [active] 714359006392 putative catalytic residue [active] 714359006393 dimerization interface [polypeptide binding]; other site 714359006394 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 714359006395 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714359006396 ATP binding site [chemical binding]; other site 714359006397 putative Mg++ binding site [ion binding]; other site 714359006398 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714359006399 nucleotide binding region [chemical binding]; other site 714359006400 ATP-binding site [chemical binding]; other site 714359006401 RQC domain; Region: RQC; cl09632 714359006402 HRDC domain; Region: HRDC; cl02578 714359006403 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 714359006404 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 714359006405 active site 714359006406 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 714359006407 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 714359006408 active site 714359006409 metal binding site [ion binding]; metal-binding site 714359006410 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 714359006411 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 714359006412 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 714359006413 DHHA2 domain; Region: DHHA2; pfam02833 714359006414 Chitin binding domain; Region: Chitin_bind_3; cl03871 714359006415 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359006416 Coenzyme A binding pocket [chemical binding]; other site 714359006417 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 714359006418 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 714359006419 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 714359006420 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 714359006421 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 714359006422 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 714359006423 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 714359006424 NAD(P) binding site [chemical binding]; other site 714359006425 catalytic residues [active] 714359006426 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 714359006427 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 714359006428 inhibitor site; inhibition site 714359006429 active site 714359006430 dimer interface [polypeptide binding]; other site 714359006431 catalytic residue [active] 714359006432 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 714359006433 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 714359006434 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 714359006435 Proline racemase; Region: Pro_racemase; pfam05544 714359006436 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 714359006437 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359006438 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 714359006439 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359006440 Walker A motif; other site 714359006441 ATP binding site [chemical binding]; other site 714359006442 Walker B motif; other site 714359006443 arginine finger; other site 714359006444 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359006445 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 714359006446 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 714359006447 catalytic loop [active] 714359006448 iron binding site [ion binding]; other site 714359006449 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 714359006450 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359006451 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 714359006452 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 714359006453 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 714359006454 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 714359006455 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 714359006456 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 714359006457 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 714359006458 DltD N-terminal region; Region: DltD_N; pfam04915 714359006459 DltD central region; Region: DltD_M; pfam04918 714359006460 DltD C-terminal region; Region: DltD_C; pfam04914 714359006461 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359006462 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 714359006463 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 714359006464 peptide binding site [polypeptide binding]; other site 714359006465 NlpC/P60 family; Region: NLPC_P60; cl11438 714359006466 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 714359006467 o-succinylbenzoic acid (OSB) synthetase; Region: menC_lowGC/arch; TIGR01928 714359006468 active site 714359006469 Septum formation initiator; Region: DivIC; cl11433 714359006470 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 714359006471 active site 714359006472 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 714359006473 conserved cys residue [active] 714359006474 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 714359006475 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 714359006476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359006477 S-adenosylmethionine binding site [chemical binding]; other site 714359006478 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 714359006479 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 714359006480 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 714359006481 PPIC-type PPIASE domain; Region: Rotamase; cl08278 714359006482 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359006483 dimerization interface [polypeptide binding]; other site 714359006484 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359006485 dimer interface [polypeptide binding]; other site 714359006486 phosphorylation site [posttranslational modification] 714359006487 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359006488 ATP binding site [chemical binding]; other site 714359006489 Mg2+ binding site [ion binding]; other site 714359006490 G-X-G motif; other site 714359006491 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359006492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359006493 active site 714359006494 phosphorylation site [posttranslational modification] 714359006495 intermolecular recognition site; other site 714359006496 dimerization interface [polypeptide binding]; other site 714359006497 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359006498 DNA binding site [nucleotide binding] 714359006499 DinB superfamily; Region: DinB_2; cl00986 714359006500 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359006501 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 714359006502 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 714359006503 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 714359006504 5'-methylthioadenosine nucleosidase; Region: PLN02584 714359006505 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 714359006506 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 714359006507 Zn binding site [ion binding]; other site 714359006508 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 714359006509 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 714359006510 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 714359006511 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 714359006512 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359006513 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359006514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359006515 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359006516 putative substrate translocation pore; other site 714359006517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359006518 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 714359006519 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 714359006520 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 714359006521 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 714359006522 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 714359006523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359006524 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359006525 putative substrate translocation pore; other site 714359006526 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 714359006527 active site 714359006528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359006529 S-adenosylmethionine binding site [chemical binding]; other site 714359006530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359006531 putative substrate translocation pore; other site 714359006532 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359006533 aspartate aminotransferase; Provisional; Region: PRK07681 714359006534 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714359006535 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359006536 homodimer interface [polypeptide binding]; other site 714359006537 catalytic residue [active] 714359006538 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 714359006539 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 714359006540 hypothetical protein; Provisional; Region: PRK13679 714359006541 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 714359006542 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359006543 Walker A/P-loop; other site 714359006544 ATP binding site [chemical binding]; other site 714359006545 Q-loop/lid; other site 714359006546 ABC transporter signature motif; other site 714359006547 Walker B; other site 714359006548 D-loop; other site 714359006549 H-loop/switch region; other site 714359006550 Predicted transcriptional regulators [Transcription]; Region: COG1725 714359006551 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359006552 DNA-binding site [nucleotide binding]; DNA binding site 714359006553 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 714359006554 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 714359006555 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 714359006556 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 714359006557 Domain of unknown function DUF20; Region: UPF0118; cl00465 714359006558 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 714359006559 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 714359006560 active site 714359006561 dimer interface [polypeptide binding]; other site 714359006562 non-prolyl cis peptide bond; other site 714359006563 insertion regions; other site 714359006564 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 714359006565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 714359006566 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 714359006567 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714359006568 substrate binding pocket [chemical binding]; other site 714359006569 membrane-bound complex binding site; other site 714359006570 hinge residues; other site 714359006571 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 714359006572 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 714359006573 Walker A/P-loop; other site 714359006574 ATP binding site [chemical binding]; other site 714359006575 Q-loop/lid; other site 714359006576 ABC transporter signature motif; other site 714359006577 Walker B; other site 714359006578 D-loop; other site 714359006579 H-loop/switch region; other site 714359006580 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359006581 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359006582 Protein of unknown function (DUF402); Region: DUF402; cl00979 714359006583 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 714359006584 binding surface 714359006585 TPR motif; other site 714359006586 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 714359006587 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 714359006588 DinB superfamily; Region: DinB_2; cl00986 714359006589 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714359006590 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359006591 Coenzyme A binding pocket [chemical binding]; other site 714359006592 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714359006593 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359006594 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 714359006595 active site 714359006596 NTP binding site [chemical binding]; other site 714359006597 metal binding triad [ion binding]; metal-binding site 714359006598 antibiotic binding site [chemical binding]; other site 714359006599 A new structural DNA glycosylase; Region: AlkD_like; cd06561 714359006600 active site 714359006601 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359006602 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 714359006603 active site 714359006604 metal binding site [ion binding]; metal-binding site 714359006605 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 714359006606 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 714359006607 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 714359006608 Integral membrane protein TerC family; Region: TerC; cl10468 714359006609 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 714359006610 Sulfatase; Region: Sulfatase; cl10460 714359006611 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 714359006612 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359006613 Walker A/P-loop; other site 714359006614 ATP binding site [chemical binding]; other site 714359006615 Q-loop/lid; other site 714359006616 ABC transporter signature motif; other site 714359006617 Walker B; other site 714359006618 D-loop; other site 714359006619 H-loop/switch region; other site 714359006620 ABC transporter; Region: ABC_tran_2; pfam12848 714359006621 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 714359006622 hypothetical protein; Provisional; Region: PRK06761 714359006623 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 714359006624 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 714359006625 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359006626 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359006627 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 714359006628 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359006629 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 714359006630 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 714359006631 hinge; other site 714359006632 active site 714359006633 prephenate dehydrogenase; Validated; Region: PRK06545 714359006634 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359006635 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 714359006636 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 714359006637 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714359006638 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359006639 homodimer interface [polypeptide binding]; other site 714359006640 catalytic residue [active] 714359006641 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 714359006642 Tetramer interface [polypeptide binding]; other site 714359006643 active site 714359006644 FMN-binding site [chemical binding]; other site 714359006645 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 714359006646 Chorismate mutase type II; Region: CM_2; cl00693 714359006647 NeuB family; Region: NeuB; cl00496 714359006648 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 714359006649 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 714359006650 Isochorismatase family; Region: Isochorismatase; pfam00857 714359006651 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 714359006652 catalytic triad [active] 714359006653 conserved cis-peptide bond; other site 714359006654 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714359006655 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359006656 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359006657 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 714359006658 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359006659 putative metal binding site [ion binding]; other site 714359006660 Berberine and berberine like; Region: BBE; pfam08031 714359006661 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 714359006662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359006663 putative substrate translocation pore; other site 714359006664 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359006665 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359006666 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837 714359006667 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359006668 Predicted dehydrogenase [General function prediction only]; Region: COG0579 714359006669 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 714359006670 ligand binding site [chemical binding]; other site 714359006671 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 714359006672 TM-ABC transporter signature motif; other site 714359006673 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 714359006674 TM-ABC transporter signature motif; other site 714359006675 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 714359006676 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 714359006677 Walker A/P-loop; other site 714359006678 ATP binding site [chemical binding]; other site 714359006679 Q-loop/lid; other site 714359006680 ABC transporter signature motif; other site 714359006681 Walker B; other site 714359006682 D-loop; other site 714359006683 H-loop/switch region; other site 714359006684 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 714359006685 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 714359006686 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 714359006687 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 714359006688 Autoinducer-2 kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 714359006689 putative N- and C-terminal domain interface [polypeptide binding]; other site 714359006690 putative active site [active] 714359006691 putative MgATP binding site [chemical binding]; other site 714359006692 catalytic site [active] 714359006693 metal binding site [ion binding]; metal-binding site 714359006694 putative carbohydrate binding site [chemical binding]; other site 714359006695 Cupin domain; Region: Cupin_2; cl09118 714359006696 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 714359006697 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 714359006698 putative active site; other site 714359006699 catalytic residue [active] 714359006700 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359006701 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 714359006702 active site 714359006703 metal binding site [ion binding]; metal-binding site 714359006704 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 714359006705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359006706 H+ Antiporter protein; Region: 2A0121; TIGR00900 714359006707 putative substrate translocation pore; other site 714359006708 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359006709 putative DNA binding site [nucleotide binding]; other site 714359006710 putative Zn2+ binding site [ion binding]; other site 714359006711 DinB superfamily; Region: DinB_2; cl00986 714359006712 nucleoside transporter; Region: nupC; TIGR00804 714359006713 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 714359006714 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 714359006715 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 714359006716 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 714359006717 putative catalytic cysteine [active] 714359006718 gamma-glutamyl kinase; Provisional; Region: PRK05429 714359006719 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 714359006720 nucleotide binding site [chemical binding]; other site 714359006721 homotetrameric interface [polypeptide binding]; other site 714359006722 putative phosphate binding site [ion binding]; other site 714359006723 putative allosteric binding site; other site 714359006724 PUA domain; Region: PUA; cl00607 714359006725 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359006726 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 714359006727 Arginine degradation protein (predicted deacylase) [Amino acid transport and metabolism]; Region: RocB; COG4187 714359006728 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 714359006729 putative metal binding site [ion binding]; other site 714359006730 putative dimer interface [polypeptide binding]; other site 714359006731 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359006732 Transcriptional regulator [Transcription]; Region: IclR; COG1414 714359006733 Bacterial transcriptional regulator; Region: IclR; pfam01614 714359006734 Amino acid permease; Region: AA_permease; cl00524 714359006735 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 714359006736 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 714359006737 putative metal binding site [ion binding]; other site 714359006738 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359006739 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 714359006740 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 714359006741 putative di-iron ligands [ion binding]; other site 714359006742 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 714359006743 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 714359006744 VanW like protein; Region: VanW; pfam04294 714359006745 Alkaline phosphatase homologues; Region: alkPPc; smart00098 714359006746 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 714359006747 active site 714359006748 dimer interface [polypeptide binding]; other site 714359006749 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359006750 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 714359006751 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359006752 motif II; other site 714359006753 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359006754 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714359006755 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359006756 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359006757 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 714359006758 active site 714359006759 metal binding site [ion binding]; metal-binding site 714359006760 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 714359006761 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359006762 MoxR-like ATPases [General function prediction only]; Region: COG0714 714359006763 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359006764 Walker A motif; other site 714359006765 ATP binding site [chemical binding]; other site 714359006766 Walker B motif; other site 714359006767 arginine finger; other site 714359006768 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 714359006769 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 714359006770 proline/glycine betaine transporter; Provisional; Region: PRK10642 714359006771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359006772 putative substrate translocation pore; other site 714359006773 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 714359006774 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 714359006775 active site 714359006776 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 714359006777 active site 714359006778 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 714359006779 Ligand binding site; other site 714359006780 Putative Catalytic site; other site 714359006781 DXD motif; other site 714359006782 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 714359006783 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 714359006784 active site 714359006785 acetylornithine aminotransferase; Provisional; Region: PRK02627 714359006786 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 714359006787 inhibitor-cofactor binding pocket; inhibition site 714359006788 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359006789 catalytic residue [active] 714359006790 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 714359006791 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 714359006792 heme binding pocket [chemical binding]; other site 714359006793 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 714359006794 Collagenase; Region: Peptidase_M9; pfam01752 714359006795 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 714359006796 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 714359006797 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 714359006798 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 714359006799 active site 714359006800 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 714359006801 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359006802 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 714359006803 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 714359006804 MoxR-like ATPases [General function prediction only]; Region: COG0714 714359006805 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359006806 Walker A motif; other site 714359006807 ATP binding site [chemical binding]; other site 714359006808 Walker B motif; other site 714359006809 arginine finger; other site 714359006810 Domain of unknown function (DUF1910); Region: DUF1910; pfam08928 714359006811 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 714359006812 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 714359006813 Transposase; Region: DEDD_Tnp_IS110; pfam01548 714359006814 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 714359006815 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 714359006816 Recombinase; Region: Recombinase; pfam07508 714359006817 Uncharacterized conserved protein [Function unknown]; Region: COG5444 714359006818 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 714359006819 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 714359006820 dimer interface [polypeptide binding]; other site 714359006821 FMN binding site [chemical binding]; other site 714359006822 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359006823 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 714359006824 Tet(M)-like subfamily. Tet(M), Tet(O), Tet(W), and OtrA are tetracycline resistance genes found in Gram-positive and Gram-negative bacteria. Tetracyclines inhibit protein synthesis by preventing aminoacyl-tRNA from binding to the ribosomal acceptor...; Region: TetM_like; cd04168 714359006825 G1 box; other site 714359006826 putative GEF interaction site [polypeptide binding]; other site 714359006827 GTP/Mg2+ binding site [chemical binding]; other site 714359006828 Switch I region; other site 714359006829 G2 box; other site 714359006830 G3 box; other site 714359006831 Switch II region; other site 714359006832 G4 box; other site 714359006833 G5 box; other site 714359006834 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 714359006835 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 714359006836 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 714359006837 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 714359006838 nudix motif; other site 714359006839 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 714359006840 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 714359006841 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 714359006842 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 714359006843 putative NAD(P) binding site [chemical binding]; other site 714359006844 active site 714359006845 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 714359006846 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 714359006847 Walker A/P-loop; other site 714359006848 ATP binding site [chemical binding]; other site 714359006849 Q-loop/lid; other site 714359006850 ABC transporter signature motif; other site 714359006851 Walker B; other site 714359006852 D-loop; other site 714359006853 H-loop/switch region; other site 714359006854 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 714359006855 FtsX-like permease family; Region: FtsX; pfam02687 714359006856 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359006857 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714359006858 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 714359006859 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714359006860 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 714359006861 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359006862 Coenzyme A binding pocket [chemical binding]; other site 714359006863 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 714359006864 nudix motif; other site 714359006865 EamA-like transporter family; Region: EamA; cl01037 714359006866 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 714359006867 EamA-like transporter family; Region: EamA; cl01037 714359006868 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 714359006869 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359006870 DNA-binding site [nucleotide binding]; DNA binding site 714359006871 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714359006872 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359006873 homodimer interface [polypeptide binding]; other site 714359006874 catalytic residue [active] 714359006875 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359006876 Cupin domain; Region: Cupin_2; cl09118 714359006877 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 714359006878 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 714359006879 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359006880 active site 714359006881 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 714359006882 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 714359006883 active site 714359006884 metal binding site [ion binding]; metal-binding site 714359006885 Phosphotransferase enzyme family; Region: APH; pfam01636 714359006886 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 714359006887 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 714359006888 active site 714359006889 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 714359006890 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 714359006891 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359006892 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 714359006893 Amino acid permease; Region: AA_permease; cl00524 714359006894 A new structural DNA glycosylase; Region: AlkD_like; cl11434 714359006895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 714359006896 amidase; Provisional; Region: PRK06828 714359006897 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 714359006898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 714359006899 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 714359006900 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 714359006901 Catalytic site [active] 714359006902 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 714359006903 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 714359006904 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 714359006905 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359006906 NAD-dependent deacetylase; Provisional; Region: PRK14138 714359006907 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 714359006908 NAD+ binding site [chemical binding]; other site 714359006909 substrate binding site [chemical binding]; other site 714359006910 Zn binding site [ion binding]; other site 714359006911 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 714359006912 putative substrate binding pocket [chemical binding]; other site 714359006913 AC domain interface; other site 714359006914 catalytic triad [active] 714359006915 AB domain interface; other site 714359006916 interchain disulfide; other site 714359006917 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 714359006918 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 714359006919 Protein of unknown function (DUF979); Region: DUF979; cl01572 714359006920 Protein of unknown function (DUF969); Region: DUF969; cl01573 714359006921 LamB/YcsF family; Region: LamB_YcsF; cl00664 714359006922 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 714359006923 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 714359006924 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 714359006925 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 714359006926 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 714359006927 Catalytic site [active] 714359006928 CutC family; Region: CutC; cl01218 714359006929 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359006930 dimerization interface [polypeptide binding]; other site 714359006931 putative DNA binding site [nucleotide binding]; other site 714359006932 putative Zn2+ binding site [ion binding]; other site 714359006933 DinB superfamily; Region: DinB_2; cl00986 714359006934 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 714359006935 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 714359006936 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 714359006937 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 714359006938 putative active site [active] 714359006939 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714359006940 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359006941 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 714359006942 Nucleoside recognition; Region: Gate; cl00486 714359006943 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 714359006944 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such...; Region: APH_ChoK_like_1; cd05155 714359006945 putative active site [active] 714359006946 putative substrate binding site [chemical binding]; other site 714359006947 ATP binding site [chemical binding]; other site 714359006948 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 714359006949 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359006950 Coenzyme A binding pocket [chemical binding]; other site 714359006951 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 714359006952 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 714359006953 dinuclear metal binding motif [ion binding]; other site 714359006954 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359006955 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 714359006956 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 714359006957 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359006958 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359006959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 714359006960 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 714359006961 phosphoenolpyruvate synthase; Validated; Region: PRK06241 714359006962 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 714359006963 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 714359006964 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 714359006965 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 714359006966 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 714359006967 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 714359006968 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 714359006969 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 714359006970 NAD binding site [chemical binding]; other site 714359006971 catalytic Zn binding site [ion binding]; other site 714359006972 structural Zn binding site [ion binding]; other site 714359006973 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 714359006974 dimanganese center [ion binding]; other site 714359006975 aspartate ammonia-lyase; Provisional; Region: PRK14515 714359006976 Aspartase; Region: Aspartase; cd01357 714359006977 active sites [active] 714359006978 tetramer interface [polypeptide binding]; other site 714359006979 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 714359006980 active site 714359006981 homodimer interface [polypeptide binding]; other site 714359006982 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 714359006983 Amino acid permease; Region: AA_permease; cl00524 714359006984 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 714359006985 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 714359006986 PAS domain S-box; Region: sensory_box; TIGR00229 714359006987 PAS domain S-box; Region: sensory_box; TIGR00229 714359006988 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714359006989 putative active site [active] 714359006990 heme pocket [chemical binding]; other site 714359006991 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 714359006992 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 714359006993 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359006994 dimer interface [polypeptide binding]; other site 714359006995 phosphorylation site [posttranslational modification] 714359006996 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359006997 ATP binding site [chemical binding]; other site 714359006998 Mg2+ binding site [ion binding]; other site 714359006999 G-X-G motif; other site 714359007000 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 714359007001 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 714359007002 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 714359007003 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 714359007004 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 714359007005 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714359007006 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714359007007 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 714359007008 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 714359007009 GIY-YIG motif/motif A; other site 714359007010 active site 714359007011 catalytic site [active] 714359007012 putative DNA binding site [nucleotide binding]; other site 714359007013 metal binding site [ion binding]; metal-binding site 714359007014 ethanolamine permease; Region: 2A0305; TIGR00908 714359007015 Amino acid permease; Region: AA_permease; cl00524 714359007016 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359007017 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 714359007018 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 714359007019 Amino acid permease; Region: AA_permease; cl00524 714359007020 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 714359007021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359007022 Response regulator receiver domain; Region: Response_reg; pfam00072 714359007023 active site 714359007024 phosphorylation site [posttranslational modification] 714359007025 intermolecular recognition site; other site 714359007026 dimerization interface [polypeptide binding]; other site 714359007027 YcbB domain; Region: YcbB; pfam08664 714359007028 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359007029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359007030 ATP binding site [chemical binding]; other site 714359007031 Mg2+ binding site [ion binding]; other site 714359007032 G-X-G motif; other site 714359007033 Glutaminase; Region: Glutaminase; cl00907 714359007034 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 714359007035 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 714359007036 transmembrane helices; other site 714359007037 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 714359007038 active site 714359007039 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359007040 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 714359007041 Erythromycin esterase; Region: Erythro_esteras; pfam05139 714359007042 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 714359007043 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 714359007044 putative active site [active] 714359007045 putative metal binding site [ion binding]; other site 714359007046 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 714359007047 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359007048 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 714359007049 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 714359007050 Isochorismatase family; Region: Isochorismatase; pfam00857 714359007051 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 714359007052 catalytic triad [active] 714359007053 dimer interface [polypeptide binding]; other site 714359007054 conserved cis-peptide bond; other site 714359007055 Isochorismatase family; Region: Isochorismatase; pfam00857 714359007056 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 714359007057 catalytic triad [active] 714359007058 dimer interface [polypeptide binding]; other site 714359007059 conserved cis-peptide bond; other site 714359007060 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 714359007061 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 714359007062 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 714359007063 active site 714359007064 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714359007065 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359007066 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 714359007067 dimerization interface [polypeptide binding]; other site 714359007068 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 714359007069 plasmid segregation protein ParM; Provisional; Region: PRK13917 714359007070 Heat induced stress protein YflT; Region: YflT; pfam11181 714359007071 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 714359007072 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 714359007073 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 714359007074 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 714359007075 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 714359007076 DNA photolyase; Region: DNA_photolyase; pfam00875 714359007077 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 714359007078 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 714359007079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359007080 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 714359007081 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 714359007082 zinc binding site [ion binding]; other site 714359007083 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 714359007084 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 714359007085 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 714359007086 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 714359007087 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 714359007088 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 714359007089 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714359007090 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359007091 Coenzyme A binding pocket [chemical binding]; other site 714359007092 UbiA prenyltransferase family; Region: UbiA; cl00337 714359007093 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 714359007094 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 714359007095 active site 714359007096 ATP binding site [chemical binding]; other site 714359007097 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 714359007098 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359007099 Low molecular weight phosphatase family; Region: LMWPc; cd00115 714359007100 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 714359007101 active site 714359007102 Membrane transport protein; Region: Mem_trans; cl09117 714359007103 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359007104 putative DNA binding site [nucleotide binding]; other site 714359007105 DinB superfamily; Region: DinB_2; cl00986 714359007106 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 714359007107 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 714359007108 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 714359007109 putative NAD(P) binding site [chemical binding]; other site 714359007110 active site 714359007111 putative substrate binding site [chemical binding]; other site 714359007112 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359007113 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 714359007114 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359007115 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359007116 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 714359007117 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 714359007118 NADP binding site [chemical binding]; other site 714359007119 homodimer interface [polypeptide binding]; other site 714359007120 active site 714359007121 substrate binding site [chemical binding]; other site 714359007122 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 714359007123 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 714359007124 metal binding site [ion binding]; metal-binding site 714359007125 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 714359007126 putative active site [active] 714359007127 catalytic site [active] 714359007128 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 714359007129 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 714359007130 Probable transposase; Region: OrfB_IS605; pfam01385 714359007131 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 714359007132 DNA helicase, putative; Region: TIGR00376 714359007133 Erp protein C-terminus; Region: Erp_C; pfam06780 714359007134 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359007135 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 714359007136 active site 714359007137 metal binding site [ion binding]; metal-binding site 714359007138 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 714359007139 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 714359007140 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 714359007141 putative active site [active] 714359007142 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 714359007143 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 714359007144 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359007145 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359007146 Putative mono-oxygenase ydhR; Region: ydhR; cl07420 714359007147 Transcriptional regulators [Transcription]; Region: MarR; COG1846 714359007148 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359007149 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 714359007150 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 714359007151 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 714359007152 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 714359007153 Erythromycin esterase; Region: Erythro_esteras; pfam05139 714359007154 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 714359007155 Histidine kinase; Region: HisKA_3; pfam07730 714359007156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359007157 ATP binding site [chemical binding]; other site 714359007158 Mg2+ binding site [ion binding]; other site 714359007159 G-X-G motif; other site 714359007160 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 714359007161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359007162 active site 714359007163 phosphorylation site [posttranslational modification] 714359007164 intermolecular recognition site; other site 714359007165 dimerization interface [polypeptide binding]; other site 714359007166 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714359007167 DNA binding residues [nucleotide binding] 714359007168 dimerization interface [polypeptide binding]; other site 714359007169 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 714359007170 putative metal binding site [ion binding]; other site 714359007171 cytochrome P450 83B1; Provisional; Region: PLN03234 714359007172 Cytochrome P450; Region: p450; cl12078 714359007173 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 714359007174 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 714359007175 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 714359007176 FAD binding pocket [chemical binding]; other site 714359007177 FAD binding motif [chemical binding]; other site 714359007178 catalytic residues [active] 714359007179 NAD binding pocket [chemical binding]; other site 714359007180 phosphate binding motif [ion binding]; other site 714359007181 beta-alpha-beta structure motif; other site 714359007182 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 714359007183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359007184 putative substrate translocation pore; other site 714359007185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359007186 D-cysteine desulfhydrase; Validated; Region: PRK03910 714359007187 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 714359007188 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 714359007189 catalytic residue [active] 714359007190 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 714359007191 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 714359007192 active site 714359007193 metal binding site [ion binding]; metal-binding site 714359007194 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359007195 Leucine carboxyl methyltransferase; Region: LCM; cl01306 714359007196 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 714359007197 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 714359007198 Gram positive anchor; Region: Gram_pos_anchor; cl15427 714359007199 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 714359007200 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 714359007201 Walker A/P-loop; other site 714359007202 ATP binding site [chemical binding]; other site 714359007203 Q-loop/lid; other site 714359007204 ABC transporter signature motif; other site 714359007205 Walker B; other site 714359007206 D-loop; other site 714359007207 H-loop/switch region; other site 714359007208 FtsX-like permease family; Region: FtsX; pfam02687 714359007209 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359007210 dimerization interface [polypeptide binding]; other site 714359007211 putative DNA binding site [nucleotide binding]; other site 714359007212 Predicted transcriptional regulator [Transcription]; Region: COG2345 714359007213 putative Zn2+ binding site [ion binding]; other site 714359007214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359007215 H+ Antiporter protein; Region: 2A0121; TIGR00900 714359007216 putative substrate translocation pore; other site 714359007217 DinB superfamily; Region: DinB_2; cl00986 714359007218 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 714359007219 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359007220 dimerization interface [polypeptide binding]; other site 714359007221 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359007222 dimer interface [polypeptide binding]; other site 714359007223 phosphorylation site [posttranslational modification] 714359007224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359007225 ATP binding site [chemical binding]; other site 714359007226 Mg2+ binding site [ion binding]; other site 714359007227 G-X-G motif; other site 714359007228 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359007229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359007230 active site 714359007231 phosphorylation site [posttranslational modification] 714359007232 intermolecular recognition site; other site 714359007233 dimerization interface [polypeptide binding]; other site 714359007234 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359007235 DNA binding site [nucleotide binding] 714359007236 Uncharacterized conserved protein [Function unknown]; Region: COG1284 714359007237 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 714359007238 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 714359007239 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 714359007240 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 714359007241 Protein of unknown function (DUF1015); Region: DUF1015; cl01715 714359007242 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359007243 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 714359007244 L-serine binding site [chemical binding]; other site 714359007245 ACT domain interface; other site 714359007246 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 714359007247 Aminotransferase class-V; Region: Aminotran_5; pfam00266 714359007248 homodimer interface [polypeptide binding]; other site 714359007249 substrate-cofactor binding pocket; other site 714359007250 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359007251 catalytic residue [active] 714359007252 Domain of unknown function (DUF378); Region: DUF378; cl00943 714359007253 Cupin domain; Region: Cupin_2; cl09118 714359007254 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 714359007255 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714359007256 Penicillin amidase; Region: Penicil_amidase; pfam01804 714359007257 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 714359007258 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 714359007259 active site 714359007260 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 714359007261 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 714359007262 substrate binding site [chemical binding]; other site 714359007263 amidase catalytic site [active] 714359007264 Zn binding residues [ion binding]; other site 714359007265 Bacterial SH3 domain; Region: SH3_3; cl02551 714359007266 S-layer homology domain; Region: SLH; pfam00395 714359007267 S-layer homology domain; Region: SLH; pfam00395 714359007268 S-layer homology domain; Region: SLH; pfam00395 714359007269 Protein of unknown function, DUF600; Region: DUF600; cl04640 714359007270 A new structural DNA glycosylase; Region: AlkD_like; cd06561 714359007271 active site 714359007272 Protein of unknown function, DUF600; Region: DUF600; cl04640 714359007273 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 714359007274 Annexin; Region: Annexin; cl02574 714359007275 Domain of unknown function (DUF1910); Region: DUF1910; pfam08928 714359007276 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 714359007277 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 714359007278 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 714359007279 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 714359007280 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 714359007281 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 714359007282 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 714359007283 Protein of unknown function, DUF600; Region: DUF600; cl04640 714359007284 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 714359007285 NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585 714359007286 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 714359007287 Virulence factor EsxB; Region: EsxB; pfam10663 714359007288 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 714359007289 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 714359007290 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 714359007291 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 714359007292 putative active site [active] 714359007293 putative metal binding site [ion binding]; other site 714359007294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359007295 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359007296 putative substrate translocation pore; other site 714359007297 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 714359007298 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359007299 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 714359007300 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359007301 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359007302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359007303 putative substrate translocation pore; other site 714359007304 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359007305 ABC-2 type transporter; Region: ABC2_membrane; cl11417 714359007306 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 714359007307 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359007308 Walker A/P-loop; other site 714359007309 ATP binding site [chemical binding]; other site 714359007310 Q-loop/lid; other site 714359007311 ABC transporter signature motif; other site 714359007312 Walker B; other site 714359007313 D-loop; other site 714359007314 H-loop/switch region; other site 714359007315 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359007316 Na+/H+ antiporter family; Region: Na_H_antiporter; cl15356 714359007317 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 714359007318 Uncharacterized conserved protein [Function unknown]; Region: COG4715 714359007319 SWIM zinc finger; Region: SWIM; cl15408 714359007320 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 714359007321 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 714359007322 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 714359007323 Walker A/P-loop; other site 714359007324 ATP binding site [chemical binding]; other site 714359007325 Q-loop/lid; other site 714359007326 ABC transporter signature motif; other site 714359007327 Walker B; other site 714359007328 D-loop; other site 714359007329 H-loop/switch region; other site 714359007330 Domain II of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. The...; Region: ABC_cobalt_CbiO_domain2; cd03226 714359007331 Walker A/P-loop; other site 714359007332 ATP binding site [chemical binding]; other site 714359007333 Q-loop/lid; other site 714359007334 ABC transporter signature motif; other site 714359007335 Walker B; other site 714359007336 D-loop; other site 714359007337 H-loop/switch region; other site 714359007338 Cobalt transport protein; Region: CbiQ; cl00463 714359007339 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 714359007340 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 714359007341 Na+/H+ antiporter family; Region: Na_H_antiporter; cl15356 714359007342 Endonuclease I; Region: Endonuclease_1; cl01003 714359007343 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 714359007344 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359007345 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359007346 non-specific DNA binding site [nucleotide binding]; other site 714359007347 salt bridge; other site 714359007348 sequence-specific DNA binding site [nucleotide binding]; other site 714359007349 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 714359007350 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 714359007351 putative deacylase active site [active] 714359007352 histidyl-tRNA synthetase; Provisional; Region: PRK12420 714359007353 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 714359007354 dimer interface [polypeptide binding]; other site 714359007355 motif 1; other site 714359007356 active site 714359007357 motif 2; other site 714359007358 motif 3; other site 714359007359 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 714359007360 anticodon binding site; other site 714359007361 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359007362 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 714359007363 dimer interface [polypeptide binding]; other site 714359007364 FMN binding site [chemical binding]; other site 714359007365 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 714359007366 active site 714359007367 domain interfaces; other site 714359007368 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359007369 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 714359007370 NAD(P) binding site [chemical binding]; other site 714359007371 active site 714359007372 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 714359007373 Q-loop/lid; other site 714359007374 ABC transporter signature motif; other site 714359007375 Walker B; other site 714359007376 D-loop; other site 714359007377 H-loop/switch region; other site 714359007378 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 714359007379 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359007380 non-specific DNA binding site [nucleotide binding]; other site 714359007381 salt bridge; other site 714359007382 sequence-specific DNA binding site [nucleotide binding]; other site 714359007383 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 714359007384 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359007385 motif II; other site 714359007386 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; cl01757 714359007387 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 714359007388 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12899 714359007389 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359007390 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 714359007391 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 714359007392 nudix motif; other site 714359007393 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 714359007394 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 714359007395 active site 714359007396 HIGH motif; other site 714359007397 dimer interface [polypeptide binding]; other site 714359007398 KMSKS motif; other site 714359007399 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464 714359007400 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 714359007401 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 714359007402 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 714359007403 Domain of unknown function DUF20; Region: UPF0118; cl00465 714359007404 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359007405 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 714359007406 Coenzyme A binding pocket [chemical binding]; other site 714359007407 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359007408 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 714359007409 TPR motif; other site 714359007410 binding surface 714359007411 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 714359007412 binding surface 714359007413 TPR motif; other site 714359007414 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 714359007415 hypothetical protein; Provisional; Region: PRK04164 714359007416 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 714359007417 Domain of unknown function DUF21; Region: DUF21; pfam01595 714359007418 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 714359007419 Transporter associated domain; Region: CorC_HlyC; cl08393 714359007420 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 714359007421 substrate binding site; other site 714359007422 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 714359007423 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359007424 NAD(P) binding site [chemical binding]; other site 714359007425 active site 714359007426 Hypothetical methyltransferase; Region: Methyltransf_13; pfam08421 714359007427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 714359007428 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 714359007429 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359007430 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 714359007431 NAD(P) binding site [chemical binding]; other site 714359007432 active site 714359007433 Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of...; Region: SH3; cl15350 714359007434 EamA-like transporter family; Region: EamA; cl01037 714359007435 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 714359007436 EamA-like transporter family; Region: EamA; cl01037 714359007437 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 714359007438 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 714359007439 Protein of unknown function (DUF1272); Region: DUF1272; cl01568 714359007440 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 714359007441 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 714359007442 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 714359007443 N- and C-terminal domain interface [polypeptide binding]; other site 714359007444 putative active site [active] 714359007445 catalytic site [active] 714359007446 metal binding site [ion binding]; metal-binding site 714359007447 carbohydrate binding site [chemical binding]; other site 714359007448 ATP binding site [chemical binding]; other site 714359007449 GntP family permease; Region: GntP_permease; cl15264 714359007450 gluconate transporter; Region: gntP; TIGR00791 714359007451 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 714359007452 active site 714359007453 intersubunit interactions; other site 714359007454 catalytic residue [active] 714359007455 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359007456 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 714359007457 transketolase; Reviewed; Region: PRK05899 714359007458 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 714359007459 TPP-binding site [chemical binding]; other site 714359007460 dimer interface [polypeptide binding]; other site 714359007461 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 714359007462 PYR/PP interface [polypeptide binding]; other site 714359007463 dimer interface [polypeptide binding]; other site 714359007464 TPP binding site [chemical binding]; other site 714359007465 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 714359007466 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 714359007467 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 714359007468 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 714359007469 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 714359007470 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 714359007471 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 714359007472 putative NAD(P) binding site [chemical binding]; other site 714359007473 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 714359007474 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 714359007475 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 714359007476 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 714359007477 putative NAD(P) binding site [chemical binding]; other site 714359007478 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 714359007479 classical (c) SDRs; Region: SDR_c; cd05233 714359007480 NAD(P) binding site [chemical binding]; other site 714359007481 active site 714359007482 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 714359007483 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 714359007484 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 714359007485 active site 714359007486 Zn binding site [ion binding]; other site 714359007487 Viral enhancin protein; Region: Enhancin; pfam03272 714359007488 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_2; pfam12729 714359007489 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359007490 dimerization interface [polypeptide binding]; other site 714359007491 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These transmembrane...; Region: TarH; cl00144 714359007492 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl01869 714359007493 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 714359007494 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 714359007495 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 714359007496 catalytic motif [active] 714359007497 Zn binding site [ion binding]; other site 714359007498 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 714359007499 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 714359007500 dimerization interface [polypeptide binding]; other site 714359007501 active site 714359007502 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359007503 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 714359007504 dimer interface [polypeptide binding]; other site 714359007505 FMN binding site [chemical binding]; other site 714359007506 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 714359007507 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 714359007508 active site 714359007509 catalytic tetrad [active] 714359007510 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 714359007511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359007512 putative substrate translocation pore; other site 714359007513 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 714359007514 active site 1 [active] 714359007515 dimer interface [polypeptide binding]; other site 714359007516 hexamer interface [polypeptide binding]; other site 714359007517 active site 2 [active] 714359007518 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 714359007519 Domain of unknown function (DUF336); Region: DUF336; cl01249 714359007520 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 714359007521 Amino acid permease; Region: AA_permease; cl00524 714359007522 IDEAL domain; Region: IDEAL; cl07452 714359007523 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 714359007524 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359007525 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 714359007526 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359007527 DNA-binding site [nucleotide binding]; DNA binding site 714359007528 UTRA domain; Region: UTRA; cl01230 714359007529 putative oxidoreductase; Provisional; Region: PRK10206 714359007530 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359007531 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 714359007532 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 714359007533 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 714359007534 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359007535 S-adenosylmethionine binding site [chemical binding]; other site 714359007536 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359007537 dimerization interface [polypeptide binding]; other site 714359007538 putative DNA binding site [nucleotide binding]; other site 714359007539 putative Zn2+ binding site [ion binding]; other site 714359007540 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 714359007541 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 714359007542 active site 714359007543 catalytic tetrad [active] 714359007544 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 714359007545 putative hydrophobic ligand binding site [chemical binding]; other site 714359007546 protein interface [polypeptide binding]; other site 714359007547 gate; other site 714359007548 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 714359007549 catalytic triad [active] 714359007550 oxyanion hole [active] 714359007551 active site 714359007552 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 714359007553 Phosphotransferase enzyme family; Region: APH; pfam01636 714359007554 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 714359007555 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 714359007556 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 714359007557 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 714359007558 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359007559 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 714359007560 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 714359007561 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359007562 dimerization interface [polypeptide binding]; other site 714359007563 putative DNA binding site [nucleotide binding]; other site 714359007564 putative Zn2+ binding site [ion binding]; other site 714359007565 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359007566 dimerization interface [polypeptide binding]; other site 714359007567 putative DNA binding site [nucleotide binding]; other site 714359007568 putative Zn2+ binding site [ion binding]; other site 714359007569 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 714359007570 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359007571 putative transposase OrfB; Reviewed; Region: PHA02517 714359007572 Integrase core domain; Region: rve; cl01316 714359007573 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 714359007574 active site 714359007575 Glyco_18 domain; Region: Glyco_18; smart00636 714359007576 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 714359007577 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 714359007578 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 714359007579 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 714359007580 DXD motif; other site 714359007581 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 714359007582 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 714359007583 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359007584 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 714359007585 active site 714359007586 LysE type translocator; Region: LysE; cl00565 714359007587 VPS10 domain; Region: VPS10; smart00602 714359007588 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 714359007589 Predicted transcriptional regulator [Transcription]; Region: COG2378 714359007590 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359007591 ABC-2 type transporter; Region: ABC2_membrane; cl11417 714359007592 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 714359007593 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359007594 Walker A/P-loop; other site 714359007595 ATP binding site [chemical binding]; other site 714359007596 Q-loop/lid; other site 714359007597 ABC transporter signature motif; other site 714359007598 Walker B; other site 714359007599 D-loop; other site 714359007600 H-loop/switch region; other site 714359007601 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 714359007602 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 714359007603 hydroxylamine reductase; Provisional; Region: PRK12310 714359007604 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 714359007605 ACS interaction site; other site 714359007606 CODH interaction site; other site 714359007607 metal cluster binding site [ion binding]; other site 714359007608 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 714359007609 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 714359007610 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 714359007611 active site 714359007612 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 714359007613 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 714359007614 hypothetical protein; Provisional; Region: PRK06771 714359007615 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 714359007616 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359007617 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 714359007618 dimer interface [polypeptide binding]; other site 714359007619 ligand binding site [chemical binding]; other site 714359007620 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 714359007621 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 714359007622 ligand binding site [chemical binding]; other site 714359007623 flexible hinge region; other site 714359007624 Protein of unknown function, DUF606; Region: DUF606; cl01273 714359007625 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 714359007626 Amino acid permease; Region: AA_permease; cl00524 714359007627 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 714359007628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359007629 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 714359007630 putative substrate translocation pore; other site 714359007631 Haemolysin XhlA; Region: XhlA; pfam10779 714359007632 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 714359007633 classical (c) SDRs; Region: SDR_c; cd05233 714359007634 NAD(P) binding site [chemical binding]; other site 714359007635 active site 714359007636 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 714359007637 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 714359007638 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 714359007639 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 714359007640 transmembrane helices; other site 714359007641 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714359007642 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359007643 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 714359007644 putative ligand binding residues [chemical binding]; other site 714359007645 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 714359007646 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 714359007647 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714359007648 ABC-ATPase subunit interface; other site 714359007649 dimer interface [polypeptide binding]; other site 714359007650 putative PBP binding regions; other site 714359007651 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 714359007652 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714359007653 ABC-ATPase subunit interface; other site 714359007654 dimer interface [polypeptide binding]; other site 714359007655 putative PBP binding regions; other site 714359007656 Protein of unknown function (DUF817); Region: DUF817; cl01520 714359007657 DinB superfamily; Region: DinB_2; cl00986 714359007658 DinB superfamily; Region: DinB_2; cl00986 714359007659 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 714359007660 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 714359007661 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714359007662 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359007663 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 714359007664 dimerization interface [polypeptide binding]; other site 714359007665 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 714359007666 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 714359007667 NADP binding site [chemical binding]; other site 714359007668 dimer interface [polypeptide binding]; other site 714359007669 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 714359007670 catalytic core [active] 714359007671 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359007672 Coenzyme A binding pocket [chemical binding]; other site 714359007673 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 714359007674 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359007675 Walker A/P-loop; other site 714359007676 ATP binding site [chemical binding]; other site 714359007677 Q-loop/lid; other site 714359007678 ABC transporter signature motif; other site 714359007679 Walker B; other site 714359007680 D-loop; other site 714359007681 H-loop/switch region; other site 714359007682 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 714359007683 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 714359007684 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 714359007685 N-acetyltransferase; Region: Acetyltransf_2; cl00949 714359007686 oligoendopeptidase F; Region: pepF; TIGR00181 714359007687 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 714359007688 active site 714359007689 Zn binding site [ion binding]; other site 714359007690 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359007691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359007692 putative substrate translocation pore; other site 714359007693 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359007694 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714359007695 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359007696 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 714359007697 putative dimerization interface [polypeptide binding]; other site 714359007698 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 714359007699 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 714359007700 active site 714359007701 catalytic site [active] 714359007702 metal binding site [ion binding]; metal-binding site 714359007703 FAD binding domain; Region: FAD_binding_3; pfam01494 714359007704 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359007705 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 714359007706 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359007707 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359007708 dimerization interface [polypeptide binding]; other site 714359007709 putative DNA binding site [nucleotide binding]; other site 714359007710 putative Zn2+ binding site [ion binding]; other site 714359007711 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 714359007712 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 714359007713 putative NAD(P) binding site [chemical binding]; other site 714359007714 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 714359007715 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 714359007716 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 714359007717 TPR motif; other site 714359007718 binding surface 714359007719 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 714359007720 Uncharacterised protein family (UPF0157); Region: UPF0157; cl00987 714359007721 D-lactate dehydrogenase [cytochrome]; Region: PLN02805 714359007722 FAD binding domain; Region: FAD_binding_4; pfam01565 714359007723 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 714359007724 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714359007725 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359007726 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 714359007727 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 714359007728 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 714359007729 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 714359007730 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 714359007731 active site residue [active] 714359007732 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 714359007733 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 714359007734 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 714359007735 active site 714359007736 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 714359007737 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359007738 NAD(P) binding site [chemical binding]; other site 714359007739 active site 714359007740 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 714359007741 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 714359007742 NAD binding site [chemical binding]; other site 714359007743 homotetramer interface [polypeptide binding]; other site 714359007744 homodimer interface [polypeptide binding]; other site 714359007745 substrate binding site [chemical binding]; other site 714359007746 active site 714359007747 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359007748 TPR motif; other site 714359007749 binding surface 714359007750 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These transmembrane...; Region: TarH; cl00144 714359007751 dimerization interface [polypeptide binding]; other site 714359007752 ligand (aspartate) binding pocket [chemical binding]; other site 714359007753 Cache domain; Region: Cache_1; pfam02743 714359007754 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359007755 dimerization interface [polypeptide binding]; other site 714359007756 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 714359007757 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These transmembrane...; Region: TarH; cl00144 714359007758 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 714359007759 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359007760 TPR motif; other site 714359007761 binding surface 714359007762 PAS domain S-box; Region: sensory_box; TIGR00229 714359007763 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 714359007764 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714359007765 metal binding site [ion binding]; metal-binding site 714359007766 active site 714359007767 I-site; other site 714359007768 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 714359007769 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 714359007770 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 714359007771 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 714359007772 TQXA domain; Region: TQXA_dom; TIGR03934 714359007773 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359007774 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 714359007775 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359007776 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359007777 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359007778 Gram positive anchor; Region: Gram_pos_anchor; cl15427 714359007779 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 714359007780 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359007781 dimer interface [polypeptide binding]; other site 714359007782 phosphorylation site [posttranslational modification] 714359007783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359007784 ATP binding site [chemical binding]; other site 714359007785 Mg2+ binding site [ion binding]; other site 714359007786 G-X-G motif; other site 714359007787 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 714359007788 Collagenase; Region: Peptidase_M9; pfam01752 714359007789 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 714359007790 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 714359007791 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 714359007792 MgtC family; Region: MgtC; cl12207 714359007793 Predicted acetyltransferase [General function prediction only]; Region: COG3981 714359007794 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359007795 Coenzyme A binding pocket [chemical binding]; other site 714359007796 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 714359007797 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 714359007798 putative metal binding site [ion binding]; other site 714359007799 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 714359007800 active site 714359007801 metal binding site [ion binding]; metal-binding site 714359007802 VanW like protein; Region: VanW; pfam04294 714359007803 exonuclease; Provisional; Region: PRK06722 714359007804 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 714359007805 active site 714359007806 substrate binding site [chemical binding]; other site 714359007807 catalytic site [active] 714359007808 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 714359007809 DNA-binding site [nucleotide binding]; DNA binding site 714359007810 RNA-binding motif; other site 714359007811 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 714359007812 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 714359007813 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 714359007814 nudix motif; other site 714359007815 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 714359007816 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 714359007817 trimer interface [polypeptide binding]; other site 714359007818 active site 714359007819 substrate binding site [chemical binding]; other site 714359007820 CoA binding site [chemical binding]; other site 714359007821 Domain of unknown function DUF11; Region: DUF11; cl15273 714359007822 Domain of unknown function DUF11; Region: DUF11; cl15273 714359007823 Domain of unknown function DUF11; Region: DUF11; cl15273 714359007824 Domain of unknown function DUF11; Region: DUF11; cl15273 714359007825 Domain of unknown function DUF11; Region: DUF11; cl15273 714359007826 Domain of unknown function DUF11; Region: DUF11; cl15273 714359007827 Domain of unknown function DUF11; Region: DUF11; cl15273 714359007828 Domain of unknown function DUF11; Region: DUF11; cl15273 714359007829 Domain of unknown function DUF11; Region: DUF11; cl15273 714359007830 Domain of unknown function DUF11; Region: DUF11; cl15273 714359007831 Domain of unknown function DUF11; Region: DUF11; cl15273 714359007832 Domain of unknown function DUF11; Region: DUF11; cl15273 714359007833 Domain of unknown function DUF11; Region: DUF11; cl15273 714359007834 Domain of unknown function DUF11; Region: DUF11; cl15273 714359007835 short chain dehydrogenase; Provisional; Region: PRK06924 714359007836 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 714359007837 NADP binding site [chemical binding]; other site 714359007838 homodimer interface [polypeptide binding]; other site 714359007839 active site 714359007840 Predicted acetyltransferase [General function prediction only]; Region: COG3393 714359007841 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359007842 argininosuccinate lyase; Provisional; Region: PRK06705 714359007843 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 714359007844 active sites [active] 714359007845 tetramer interface [polypeptide binding]; other site 714359007846 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 714359007847 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 714359007848 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 714359007849 active site 714359007850 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 714359007851 Sodium:solute symporter family; Region: SSF; cl00456 714359007852 Protein of unknown function (DUF997); Region: DUF997; cl01614 714359007853 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 714359007854 NAD(P) binding site [chemical binding]; other site 714359007855 catalytic residues [active] 714359007856 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 714359007857 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 714359007858 NAD(P) binding site [chemical binding]; other site 714359007859 homotetramer interface [polypeptide binding]; other site 714359007860 homodimer interface [polypeptide binding]; other site 714359007861 active site 714359007862 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 714359007863 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 714359007864 Divergent PAP2 family; Region: DUF212; cl00855 714359007865 Predicted permeases [General function prediction only]; Region: RarD; COG2962 714359007866 EamA-like transporter family; Region: EamA; cl01037 714359007867 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 714359007868 Domain of unknown function DUF59; Region: DUF59; cl00941 714359007869 antiporter inner membrane protein; Provisional; Region: PRK11670 714359007870 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 714359007871 Walker A motif; other site 714359007872 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 714359007873 MoaE interaction surface [polypeptide binding]; other site 714359007874 MoeB interaction surface [polypeptide binding]; other site 714359007875 thiocarboxylated glycine; other site 714359007876 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 714359007877 MoaE homodimer interface [polypeptide binding]; other site 714359007878 MoaD interaction [polypeptide binding]; other site 714359007879 active site residues [active] 714359007880 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 714359007881 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 714359007882 dimer interface [polypeptide binding]; other site 714359007883 putative functional site; other site 714359007884 putative MPT binding site; other site 714359007885 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 714359007886 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 714359007887 ATP binding site [chemical binding]; other site 714359007888 substrate interface [chemical binding]; other site 714359007889 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 714359007890 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 714359007891 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359007892 FeS/SAM binding site; other site 714359007893 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 714359007894 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 714359007895 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 714359007896 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 714359007897 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 714359007898 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 714359007899 catalytic loop [active] 714359007900 iron binding site [ion binding]; other site 714359007901 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 714359007902 4Fe-4S binding domain; Region: Fer4; cl02805 714359007903 4Fe-4S binding domain; Region: Fer4; cl02805 714359007904 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 714359007905 [4Fe-4S] binding site [ion binding]; other site 714359007906 molybdopterin cofactor binding site; other site 714359007907 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 714359007908 molybdopterin cofactor binding site; other site 714359007909 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 714359007910 Amino acid permease; Region: AA_permease; cl00524 714359007911 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 714359007912 Amino acid permease; Region: AA_permease; cl00524 714359007913 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 714359007914 Tubulin/FtsZ family, GTPase domain; Region: Tubulin; pfam00091 714359007915 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 714359007916 metal ion-dependent adhesion site (MIDAS); other site 714359007917 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359007918 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 714359007919 active site 714359007920 metal binding site [ion binding]; metal-binding site 714359007921 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359007922 S-adenosylmethionine binding site [chemical binding]; other site 714359007923 O-methyltransferase; Region: Methyltransf_2; pfam00891 714359007924 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 714359007925 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 714359007926 peptide binding site [polypeptide binding]; other site 714359007927 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 714359007928 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 714359007929 peptide binding site [polypeptide binding]; other site 714359007930 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 714359007931 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 714359007932 peptide binding site [polypeptide binding]; other site 714359007933 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 714359007934 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 714359007935 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 714359007936 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359007937 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714359007938 DNA binding residues [nucleotide binding] 714359007939 ABC-2 type transporter; Region: ABC2_membrane; cl11417 714359007940 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 714359007941 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 714359007942 Walker A/P-loop; other site 714359007943 ATP binding site [chemical binding]; other site 714359007944 Q-loop/lid; other site 714359007945 ABC transporter signature motif; other site 714359007946 Walker B; other site 714359007947 D-loop; other site 714359007948 H-loop/switch region; other site 714359007949 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359007950 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359007951 putative oxidoreductase; Provisional; Region: PRK11579 714359007952 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359007953 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 714359007954 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 714359007955 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 714359007956 CAP-like domain; other site 714359007957 active site 714359007958 primary dimer interface [polypeptide binding]; other site 714359007959 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 714359007960 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 714359007961 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 714359007962 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 714359007963 TopoisomeraseII; Region: TOP2c; smart00433 714359007964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 714359007965 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 714359007966 anchoring element; other site 714359007967 dimer interface [polypeptide binding]; other site 714359007968 ATP binding site [chemical binding]; other site 714359007969 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 714359007970 active site 714359007971 putative metal-binding site [ion binding]; other site 714359007972 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 714359007973 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359007974 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 714359007975 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 714359007976 protein binding site [polypeptide binding]; other site 714359007977 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359007978 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359007979 active site 714359007980 phosphorylation site [posttranslational modification] 714359007981 intermolecular recognition site; other site 714359007982 dimerization interface [polypeptide binding]; other site 714359007983 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359007984 DNA binding site [nucleotide binding] 714359007985 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 714359007986 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359007987 FeS/SAM binding site; other site 714359007988 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 714359007989 Class III ribonucleotide reductase; Region: RNR_III; cd01675 714359007990 effector binding site; other site 714359007991 active site 714359007992 Zn binding site [ion binding]; other site 714359007993 glycine loop; other site 714359007994 Domain of unknown function (DUF205); Region: DUF205; cl00410 714359007995 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 714359007996 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 714359007997 active site 714359007998 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 714359007999 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 714359008000 Probable transposase; Region: OrfB_IS605; pfam01385 714359008001 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 714359008002 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 714359008003 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 714359008004 putative peptidoglycan binding site; other site 714359008005 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 714359008006 putative peptidoglycan binding site; other site 714359008007 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 714359008008 active site 714359008009 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830; cl07951 714359008010 Small acid-soluble spore protein N family; Region: SspN; cl11659 714359008011 DNA polymerase III subunit epsilon; Validated; Region: PRK06807 714359008012 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 714359008013 active site 714359008014 substrate binding site [chemical binding]; other site 714359008015 catalytic site [active] 714359008016 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 714359008017 catalytic residues [active] 714359008018 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 714359008019 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 714359008020 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359008021 Walker A/P-loop; other site 714359008022 ATP binding site [chemical binding]; other site 714359008023 Q-loop/lid; other site 714359008024 ABC transporter signature motif; other site 714359008025 Walker B; other site 714359008026 D-loop; other site 714359008027 H-loop/switch region; other site 714359008028 aconitate hydratase; Validated; Region: PRK09277 714359008029 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 714359008030 substrate binding site [chemical binding]; other site 714359008031 ligand binding site [chemical binding]; other site 714359008032 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 714359008033 substrate binding site [chemical binding]; other site 714359008034 Small acid-soluble spore protein O family; Region: SspO; cl07943 714359008035 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 714359008036 Small acid-soluble spore protein P family; Region: SspP; cl12105 714359008037 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 714359008038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359008039 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359008040 putative substrate translocation pore; other site 714359008041 alanyl-tRNA synthetase; Provisional; Region: alaS; PRK13902 714359008042 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 714359008043 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 714359008044 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 714359008045 nudix motif; other site 714359008046 SAP domain; Region: SAP; cl02640 714359008047 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 714359008048 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 714359008049 dimer interface [polypeptide binding]; other site 714359008050 active site 714359008051 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359008052 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 714359008053 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 714359008054 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359008055 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 714359008056 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 714359008057 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359008058 non-specific DNA binding site [nucleotide binding]; other site 714359008059 salt bridge; other site 714359008060 sequence-specific DNA binding site [nucleotide binding]; other site 714359008061 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714359008062 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359008063 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 714359008064 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359008065 Coenzyme A binding pocket [chemical binding]; other site 714359008066 Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278 714359008067 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 714359008068 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 714359008069 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 714359008070 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359008071 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 714359008072 dimer interface [polypeptide binding]; other site 714359008073 putative metal binding site [ion binding]; other site 714359008074 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714359008075 putative active site [active] 714359008076 heme pocket [chemical binding]; other site 714359008077 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 714359008078 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 714359008079 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359008080 dimer interface [polypeptide binding]; other site 714359008081 phosphorylation site [posttranslational modification] 714359008082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359008083 ATP binding site [chemical binding]; other site 714359008084 Mg2+ binding site [ion binding]; other site 714359008085 G-X-G motif; other site 714359008086 Predicted esterase [General function prediction only]; Region: COG0400 714359008087 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 714359008088 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 714359008089 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359008090 Zn binding site [ion binding]; other site 714359008091 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 714359008092 Zn binding site [ion binding]; other site 714359008093 Sodium:solute symporter family; Region: SSF; cl00456 714359008094 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 714359008095 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 714359008096 active site 714359008097 FMN binding site [chemical binding]; other site 714359008098 substrate binding site [chemical binding]; other site 714359008099 3Fe-4S cluster binding site [ion binding]; other site 714359008100 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 714359008101 FMN binding site [chemical binding]; other site 714359008102 active site 714359008103 substrate binding site [chemical binding]; other site 714359008104 catalytic residue [active] 714359008105 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 714359008106 Arginase family; Region: Arginase; cl00306 714359008107 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 714359008108 active site 714359008109 urocanate hydratase; Region: hutU; TIGR01228 714359008110 urocanate hydratase; Provisional; Region: PRK05414 714359008111 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 714359008112 tetramer interface [polypeptide binding]; other site 714359008113 active sites [active] 714359008114 HutP; Region: HutP; cl07944 714359008115 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359008116 S-adenosylmethionine binding site [chemical binding]; other site 714359008117 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 714359008118 conserved cys residue [active] 714359008119 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359008120 active site 714359008121 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 714359008122 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 714359008123 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 714359008124 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 714359008125 EamA-like transporter family; Region: EamA; cl01037 714359008126 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 714359008127 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 714359008128 metal binding site [ion binding]; metal-binding site 714359008129 ABC-2 type transporter; Region: ABC2_membrane; cl11417 714359008130 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 714359008131 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359008132 Walker A/P-loop; other site 714359008133 ATP binding site [chemical binding]; other site 714359008134 Q-loop/lid; other site 714359008135 ABC transporter signature motif; other site 714359008136 Walker B; other site 714359008137 D-loop; other site 714359008138 H-loop/switch region; other site 714359008139 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 714359008140 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359008141 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 714359008142 putative dimerization interface [polypeptide binding]; other site 714359008143 putative substrate binding pocket [chemical binding]; other site 714359008144 LrgB-like family; Region: LrgB; cl00596 714359008145 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 714359008146 nudix motif; other site 714359008147 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 714359008148 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 714359008149 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 714359008150 active site 714359008151 Bacterial SH3 domain; Region: SH3_3; cl02551 714359008152 Bacterial SH3 domain; Region: SH3_3; cl02551 714359008153 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 714359008154 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 714359008155 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 714359008156 Walker A/P-loop; other site 714359008157 ATP binding site [chemical binding]; other site 714359008158 Q-loop/lid; other site 714359008159 ABC transporter signature motif; other site 714359008160 Walker B; other site 714359008161 D-loop; other site 714359008162 H-loop/switch region; other site 714359008163 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 714359008164 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 714359008165 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359008166 Walker A/P-loop; other site 714359008167 ATP binding site [chemical binding]; other site 714359008168 Q-loop/lid; other site 714359008169 ABC transporter signature motif; other site 714359008170 Walker B; other site 714359008171 D-loop; other site 714359008172 H-loop/switch region; other site 714359008173 Uncharacterised protein family (UPF0154); Region: UPF0154; cl01536 714359008174 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 714359008175 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 714359008176 TPP-binding site [chemical binding]; other site 714359008177 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 714359008178 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 714359008179 PYR/PP interface [polypeptide binding]; other site 714359008180 dimer interface [polypeptide binding]; other site 714359008181 TPP binding site [chemical binding]; other site 714359008182 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359008183 dimer interface [polypeptide binding]; other site 714359008184 conserved gate region; other site 714359008185 ABC-ATPase subunit interface; other site 714359008186 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 714359008187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 714359008188 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 714359008189 Q-loop/lid; other site 714359008190 ABC transporter signature motif; other site 714359008191 Walker B; other site 714359008192 D-loop; other site 714359008193 H-loop/switch region; other site 714359008194 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 714359008195 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714359008196 membrane-bound complex binding site; other site 714359008197 hinge residues; other site 714359008198 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 714359008199 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 714359008200 active site 714359008201 metal binding site [ion binding]; metal-binding site 714359008202 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 714359008203 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 714359008204 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 714359008205 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 714359008206 catalytic residues [active] 714359008207 catalytic nucleophile [active] 714359008208 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359008209 LexA repressor; Validated; Region: PRK00215 714359008210 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 714359008211 Catalytic site [active] 714359008212 Uncharacterized conserved protein [Function unknown]; Region: COG3595 714359008213 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 714359008214 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359008215 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 714359008216 amidase catalytic site [active] 714359008217 Zn binding residues [ion binding]; other site 714359008218 substrate binding site [chemical binding]; other site 714359008219 Bacterial SH3 domain; Region: SH3_3; cl02551 714359008220 Haemolysin XhlA; Region: XhlA; pfam10779 714359008221 Peptidase family M23; Region: Peptidase_M23; pfam01551 714359008222 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 714359008223 catalytic residue [active] 714359008224 Protein of unknown function (DUF1492); Region: DUF1492; pfam07374 714359008225 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 714359008226 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 714359008227 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 714359008228 ORF6C domain; Region: ORF6C; pfam10552 714359008229 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359008230 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 714359008231 non-specific DNA binding site [nucleotide binding]; other site 714359008232 salt bridge; other site 714359008233 sequence-specific DNA binding site [nucleotide binding]; other site 714359008234 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 714359008235 Catalytic site [active] 714359008236 glutamine synthetase, type I; Region: GlnA; TIGR00653 714359008237 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 714359008238 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 714359008239 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 714359008240 DNA binding residues [nucleotide binding] 714359008241 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 714359008242 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 714359008243 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 714359008244 catalytic residue [active] 714359008245 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 714359008246 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 714359008247 G1 box; other site 714359008248 GTP/Mg2+ binding site [chemical binding]; other site 714359008249 Switch I region; other site 714359008250 G2 box; other site 714359008251 G3 box; other site 714359008252 Switch II region; other site 714359008253 G4 box; other site 714359008254 G5 box; other site 714359008255 Predicted membrane protein [Function unknown]; Region: COG2860 714359008256 UPF0126 domain; Region: UPF0126; pfam03458 714359008257 UPF0126 domain; Region: UPF0126; pfam03458 714359008258 stage V sporulation protein K; Region: spore_V_K; TIGR02881 714359008259 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359008260 Walker A motif; other site 714359008261 ATP binding site [chemical binding]; other site 714359008262 Walker B motif; other site 714359008263 arginine finger; other site 714359008264 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 714359008265 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 714359008266 DNA binding site [nucleotide binding] 714359008267 active site 714359008268 Int/Topo IB signature motif; other site 714359008269 catalytic residues [active] 714359008270 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 714359008271 Sm1 motif; other site 714359008272 intra - hexamer interaction site; other site 714359008273 inter - hexamer interaction site [polypeptide binding]; other site 714359008274 nucleotide binding pocket [chemical binding]; other site 714359008275 Sm2 motif; other site 714359008276 IPP transferase; Region: IPPT; cl00403 714359008277 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 714359008278 Bacterial SH3 domain; Region: SH3_3; cl02551 714359008279 Bacterial SH3 domain; Region: SH3_3; cl02551 714359008280 3D domain; Region: 3D; cl01439 714359008281 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 714359008282 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 714359008283 active site 714359008284 phosphorylation site [posttranslational modification] 714359008285 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 714359008286 P-loop; other site 714359008287 active site 714359008288 phosphorylation site [posttranslational modification] 714359008289 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 714359008290 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 714359008291 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 714359008292 putative substrate binding site [chemical binding]; other site 714359008293 putative ATP binding site [chemical binding]; other site 714359008294 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 714359008295 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359008296 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 714359008297 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 714359008298 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 714359008299 dimer interface [polypeptide binding]; other site 714359008300 active site 714359008301 metal binding site [ion binding]; metal-binding site 714359008302 Protein of unknown function (DUF420); Region: DUF420; cl00989 714359008303 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 714359008304 Amino acid permease; Region: AA_permease; cl00524 714359008305 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 714359008306 Glyco_18 domain; Region: Glyco_18; smart00636 714359008307 putative active site [active] 714359008308 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 714359008309 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 714359008310 putative active site [active] 714359008311 putative metal binding site [ion binding]; other site 714359008312 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 714359008313 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 714359008314 IHF dimer interface [polypeptide binding]; other site 714359008315 IHF - DNA interface [nucleotide binding]; other site 714359008316 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359008317 Coenzyme A binding pocket [chemical binding]; other site 714359008318 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 714359008319 metal-binding site [ion binding] 714359008320 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 714359008321 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 714359008322 metal-binding site [ion binding] 714359008323 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 714359008324 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 714359008325 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 714359008326 metal-binding site [ion binding] 714359008327 Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157 714359008328 putative homotetramer interface [polypeptide binding]; other site 714359008329 putative homodimer interface [polypeptide binding]; other site 714359008330 allosteric switch controlling residues; other site 714359008331 putative metal binding site [ion binding]; other site 714359008332 putative homodimer-homodimer interface [polypeptide binding]; other site 714359008333 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 714359008334 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 714359008335 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 714359008336 Walker A/P-loop; other site 714359008337 ATP binding site [chemical binding]; other site 714359008338 Q-loop/lid; other site 714359008339 ABC transporter signature motif; other site 714359008340 Walker B; other site 714359008341 D-loop; other site 714359008342 H-loop/switch region; other site 714359008343 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714359008344 ABC-ATPase subunit interface; other site 714359008345 dimer interface [polypeptide binding]; other site 714359008346 putative PBP binding regions; other site 714359008347 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714359008348 ABC-ATPase subunit interface; other site 714359008349 dimer interface [polypeptide binding]; other site 714359008350 putative PBP binding regions; other site 714359008351 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 714359008352 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 714359008353 putative ligand binding residues [chemical binding]; other site 714359008354 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 714359008355 active site 714359008356 DNA binding site [nucleotide binding] 714359008357 putative phosphate binding site [ion binding]; other site 714359008358 putative catalytic site [active] 714359008359 metal binding site A [ion binding]; metal-binding site 714359008360 AP binding site [nucleotide binding]; other site 714359008361 metal binding site B [ion binding]; metal-binding site 714359008362 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 714359008363 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 714359008364 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714359008365 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714359008366 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 714359008367 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 714359008368 DNA binding site [nucleotide binding] 714359008369 active site 714359008370 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 714359008371 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 714359008372 endonuclease III; Region: ENDO3c; smart00478 714359008373 minor groove reading motif; other site 714359008374 helix-hairpin-helix signature motif; other site 714359008375 substrate binding pocket [chemical binding]; other site 714359008376 active site 714359008377 peptidase T; Region: peptidase-T; TIGR01882 714359008378 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 714359008379 metal binding site [ion binding]; metal-binding site 714359008380 dimer interface [polypeptide binding]; other site 714359008381 hypothetical protein; Provisional; Region: PRK06764 714359008382 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 714359008383 catalytic core [active] 714359008384 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359008385 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 714359008386 PAS domain S-box; Region: sensory_box; TIGR00229 714359008387 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 714359008388 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714359008389 metal binding site [ion binding]; metal-binding site 714359008390 active site 714359008391 I-site; other site 714359008392 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 714359008393 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 714359008394 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 714359008395 active site 714359008396 homodimer interface [polypeptide binding]; other site 714359008397 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359008398 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 714359008399 NAD(P) binding site [chemical binding]; other site 714359008400 active site 714359008401 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 714359008402 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 714359008403 NAD(P) binding site [chemical binding]; other site 714359008404 homodimer interface [polypeptide binding]; other site 714359008405 substrate binding site [chemical binding]; other site 714359008406 active site 714359008407 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 714359008408 Uncharacterised protein from bacillus cereus group; Region: YfmQ; pfam10787 714359008409 LrgB-like family; Region: LrgB; cl00596 714359008410 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 714359008411 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359008412 DNA-binding site [nucleotide binding]; DNA binding site 714359008413 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714359008414 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359008415 homodimer interface [polypeptide binding]; other site 714359008416 catalytic residue [active] 714359008417 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 714359008418 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359008419 DNA-binding site [nucleotide binding]; DNA binding site 714359008420 UTRA domain; Region: UTRA; cl01230 714359008421 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 714359008422 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 714359008423 active site 714359008424 catalytic site [active] 714359008425 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 714359008426 putative active site [active] 714359008427 putative catalytic triad [active] 714359008428 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 714359008429 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 714359008430 putative peptidoglycan binding site; other site 714359008431 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 714359008432 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 714359008433 putative peptidoglycan binding site; other site 714359008434 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 714359008435 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 714359008436 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359008437 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 714359008438 Sulfatase; Region: Sulfatase; cl10460 714359008439 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359008440 binding surface 714359008441 TPR motif; other site 714359008442 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 714359008443 G1 box; other site 714359008444 GTP/Mg2+ binding site [chemical binding]; other site 714359008445 Switch I region; other site 714359008446 G2 box; other site 714359008447 Switch II region; other site 714359008448 G3 box; other site 714359008449 G4 box; other site 714359008450 G5 box; other site 714359008451 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 714359008452 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359008453 ATP binding site [chemical binding]; other site 714359008454 Mg2+ binding site [ion binding]; other site 714359008455 G-X-G motif; other site 714359008456 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 714359008457 ATP binding site [chemical binding]; other site 714359008458 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 714359008459 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 714359008460 MutS domain I; Region: MutS_I; pfam01624 714359008461 MutS domain II; Region: MutS_II; pfam05188 714359008462 MutS family domain IV; Region: MutS_IV; pfam05190 714359008463 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 714359008464 Walker A/P-loop; other site 714359008465 ATP binding site [chemical binding]; other site 714359008466 Q-loop/lid; other site 714359008467 ABC transporter signature motif; other site 714359008468 Walker B; other site 714359008469 D-loop; other site 714359008470 H-loop/switch region; other site 714359008471 Outer spore coat protein E (CotE); Region: CotE; pfam10628 714359008472 Protein of unknown function (DUF964); Region: DUF964; cl01483 714359008473 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 714359008474 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 714359008475 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359008476 FeS/SAM binding site; other site 714359008477 TRAM domain; Region: TRAM; cl01282 714359008478 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 714359008479 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 714359008480 TPP-binding site [chemical binding]; other site 714359008481 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 714359008482 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 714359008483 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 714359008484 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 714359008485 dimer interface [polypeptide binding]; other site 714359008486 PYR/PP interface [polypeptide binding]; other site 714359008487 TPP binding site [chemical binding]; other site 714359008488 substrate binding site [chemical binding]; other site 714359008489 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 714359008490 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 714359008491 active site 714359008492 dimer interface [polypeptide binding]; other site 714359008493 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 714359008494 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 714359008495 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 714359008496 putative active site [active] 714359008497 metal binding site [ion binding]; metal-binding site 714359008498 homodimer binding site [polypeptide binding]; other site 714359008499 phosphodiesterase; Provisional; Region: PRK12704 714359008500 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 714359008501 recombinase A; Provisional; Region: recA; PRK09354 714359008502 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 714359008503 hexamer interface [polypeptide binding]; other site 714359008504 Walker A motif; other site 714359008505 ATP binding site [chemical binding]; other site 714359008506 Walker B motif; other site 714359008507 competence damage-inducible protein A; Provisional; Region: PRK00549 714359008508 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 714359008509 putative MPT binding site; other site 714359008510 Competence-damaged protein; Region: CinA; cl00666 714359008511 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 714359008512 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359008513 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 714359008514 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 714359008515 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 714359008516 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 714359008517 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359008518 NAD(P) binding site [chemical binding]; other site 714359008519 active site 714359008520 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 714359008521 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 714359008522 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 714359008523 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 714359008524 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 714359008525 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 714359008526 TM-ABC transporter signature motif; other site 714359008527 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 714359008528 TM-ABC transporter signature motif; other site 714359008529 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 714359008530 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 714359008531 Walker A/P-loop; other site 714359008532 ATP binding site [chemical binding]; other site 714359008533 Q-loop/lid; other site 714359008534 ABC transporter signature motif; other site 714359008535 Walker B; other site 714359008536 D-loop; other site 714359008537 H-loop/switch region; other site 714359008538 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 714359008539 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 714359008540 ligand binding site [chemical binding]; other site 714359008541 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 714359008542 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359008543 DNA-binding site [nucleotide binding]; DNA binding site 714359008544 UTRA domain; Region: UTRA; cl01230 714359008545 Tetraspanin family; Region: Tetraspannin; pfam00335 714359008546 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359008547 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 714359008548 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 714359008549 active site 714359008550 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 714359008551 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 714359008552 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 714359008553 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 714359008554 dihydrodipicolinate synthase; Region: dapA; TIGR00674 714359008555 dimer interface [polypeptide binding]; other site 714359008556 active site 714359008557 catalytic residue [active] 714359008558 aspartate kinase I; Reviewed; Region: PRK08210 714359008559 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 714359008560 nucleotide binding site [chemical binding]; other site 714359008561 substrate binding site [chemical binding]; other site 714359008562 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 714359008563 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 714359008564 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 714359008565 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359008566 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 714359008567 Flavoprotein; Region: Flavoprotein; cl08021 714359008568 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 714359008569 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359008570 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 714359008571 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 714359008572 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 714359008573 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 714359008574 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 714359008575 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 714359008576 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 714359008577 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 714359008578 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 714359008579 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 714359008580 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 714359008581 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 714359008582 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 714359008583 putative nucleic acid binding region [nucleotide binding]; other site 714359008584 G-X-X-G motif; other site 714359008585 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 714359008586 RNA binding site [nucleotide binding]; other site 714359008587 domain interface; other site 714359008588 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 714359008589 16S/18S rRNA binding site [nucleotide binding]; other site 714359008590 S13e-L30e interaction site [polypeptide binding]; other site 714359008591 25S rRNA binding site [nucleotide binding]; other site 714359008592 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 714359008593 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 714359008594 active site 714359008595 Riboflavin kinase; Region: Flavokinase; cl03312 714359008596 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 714359008597 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 714359008598 RNA binding site [nucleotide binding]; other site 714359008599 active site 714359008600 Ribosome-binding factor A; Region: RBFA; cl00542 714359008601 Protein of unknown function (DUF503); Region: DUF503; cl00669 714359008602 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 714359008603 translation initiation factor IF-2; Region: IF-2; TIGR00487 714359008604 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 714359008605 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases; Region: IF2_eIF5B; cd01887 714359008606 G1 box; other site 714359008607 putative GEF interaction site [polypeptide binding]; other site 714359008608 GTP/Mg2+ binding site [chemical binding]; other site 714359008609 Switch I region; other site 714359008610 G2 box; other site 714359008611 G3 box; other site 714359008612 Switch II region; other site 714359008613 G4 box; other site 714359008614 G5 box; other site 714359008615 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 714359008616 Translation-initiation factor 2; Region: IF-2; pfam11987 714359008617 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 714359008618 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 714359008619 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 714359008620 putative RNA binding cleft [nucleotide binding]; other site 714359008621 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 714359008622 NusA N-terminal domain; Region: NusA_N; pfam08529 714359008623 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 714359008624 RNA binding site [nucleotide binding]; other site 714359008625 homodimer interface [polypeptide binding]; other site 714359008626 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 714359008627 G-X-X-G motif; other site 714359008628 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 714359008629 G-X-X-G motif; other site 714359008630 ribosome maturation protein RimP; Reviewed; Region: PRK00092 714359008631 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 714359008632 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 714359008633 Sm1 motif; other site 714359008634 predicted subunit interaction site [polypeptide binding]; other site 714359008635 RNA binding pocket [nucleotide binding]; other site 714359008636 Sm2 motif; other site 714359008637 DNA polymerase III PolC; Validated; Region: polC; PRK00448 714359008638 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 714359008639 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 714359008640 generic binding surface II; other site 714359008641 generic binding surface I; other site 714359008642 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 714359008643 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 714359008644 active site 714359008645 substrate binding site [chemical binding]; other site 714359008646 catalytic site [active] 714359008647 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 714359008648 prolyl-tRNA synthetase; Provisional; Region: PRK09194 714359008649 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 714359008650 dimer interface [polypeptide binding]; other site 714359008651 motif 1; other site 714359008652 active site 714359008653 motif 2; other site 714359008654 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 714359008655 putative deacylase active site [active] 714359008656 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 714359008657 active site 714359008658 motif 3; other site 714359008659 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 714359008660 anticodon binding site; other site 714359008661 RIP metalloprotease RseP; Region: TIGR00054 714359008662 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 714359008663 active site 714359008664 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 714359008665 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 714359008666 protein binding site [polypeptide binding]; other site 714359008667 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 714359008668 putative substrate binding region [chemical binding]; other site 714359008669 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 714359008670 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 714359008671 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 714359008672 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 714359008673 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 714359008674 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 714359008675 catalytic residue [active] 714359008676 putative FPP diphosphate binding site; other site 714359008677 putative FPP binding hydrophobic cleft; other site 714359008678 dimer interface [polypeptide binding]; other site 714359008679 putative IPP diphosphate binding site; other site 714359008680 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 714359008681 hinge region; other site 714359008682 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 714359008683 putative nucleotide binding site [chemical binding]; other site 714359008684 uridine monophosphate binding site [chemical binding]; other site 714359008685 homohexameric interface [polypeptide binding]; other site 714359008686 elongation factor Ts; Provisional; Region: tsf; PRK09377 714359008687 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 714359008688 Elongation factor TS; Region: EF_TS; pfam00889 714359008689 Elongation factor TS; Region: EF_TS; pfam00889 714359008690 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 714359008691 rRNA interaction site [nucleotide binding]; other site 714359008692 S8 interaction site; other site 714359008693 putative laminin-1 binding site; other site 714359008694 transcriptional repressor CodY; Validated; Region: PRK04158 714359008695 CodY GAF-like domain; Region: CodY; pfam06018 714359008696 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359008697 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 714359008698 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359008699 Walker A motif; other site 714359008700 ATP binding site [chemical binding]; other site 714359008701 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359008702 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 714359008703 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 714359008704 HslU subunit interaction site [polypeptide binding]; other site 714359008705 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 714359008706 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 714359008707 Int/Topo IB signature motif; other site 714359008708 active site 714359008709 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 714359008710 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440 714359008711 DNA topoisomerase I; Validated; Region: PRK05582 714359008712 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 714359008713 active site 714359008714 metal binding site [ion binding]; metal-binding site 714359008715 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 714359008716 domain I; other site 714359008717 DNA binding groove [nucleotide binding] 714359008718 phosphate binding site [ion binding]; other site 714359008719 domain II; other site 714359008720 domain III; other site 714359008721 nucleotide binding site [chemical binding]; other site 714359008722 catalytic site [active] 714359008723 domain IV; other site 714359008724 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 714359008725 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 714359008726 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 714359008727 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 714359008728 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359008729 CoA-ligase; Region: Ligase_CoA; pfam00549 714359008730 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 714359008731 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 714359008732 CoA-ligase; Region: Ligase_CoA; pfam00549 714359008733 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 714359008734 RNA/DNA hybrid binding site [nucleotide binding]; other site 714359008735 active site 714359008736 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 714359008737 YlqF. Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. The...; Region: YlqF; cd01856 714359008738 GTP/Mg2+ binding site [chemical binding]; other site 714359008739 G4 box; other site 714359008740 G5 box; other site 714359008741 G1 box; other site 714359008742 Switch I region; other site 714359008743 G2 box; other site 714359008744 G3 box; other site 714359008745 Switch II region; other site 714359008746 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 714359008747 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 714359008748 Catalytic site [active] 714359008749 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 714359008750 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 714359008751 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 714359008752 RimM N-terminal domain; Region: RimM; pfam01782 714359008753 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 714359008754 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837; cl00794 714359008755 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 714359008756 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 714359008757 GTP binding site [chemical binding]; other site 714359008758 Signal peptide binding domain; Region: SRP_SPB; pfam02978 714359008759 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 714359008760 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 714359008761 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 714359008762 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 714359008763 P loop; other site 714359008764 GTP binding site [chemical binding]; other site 714359008765 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 714359008766 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359008767 Q-loop/lid; other site 714359008768 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 714359008769 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 714359008770 ABC transporter signature motif; other site 714359008771 Walker B; other site 714359008772 D-loop; other site 714359008773 H-loop/switch region; other site 714359008774 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 714359008775 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 714359008776 dimerization interface [polypeptide binding]; other site 714359008777 active site 714359008778 metal binding site [ion binding]; metal-binding site 714359008779 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 714359008780 dsRNA binding site [nucleotide binding]; other site 714359008781 Phosphopantetheine attachment site; Region: PP-binding; cl09936 714359008782 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 714359008783 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 714359008784 NAD(P) binding site [chemical binding]; other site 714359008785 homotetramer interface [polypeptide binding]; other site 714359008786 homodimer interface [polypeptide binding]; other site 714359008787 active site 714359008788 Acyl transferase domain; Region: Acyl_transf_1; cl08282 714359008789 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 714359008790 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 714359008791 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 714359008792 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 714359008793 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 714359008794 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 714359008795 generic binding surface II; other site 714359008796 ssDNA binding site; other site 714359008797 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714359008798 ATP binding site [chemical binding]; other site 714359008799 putative Mg++ binding site [ion binding]; other site 714359008800 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714359008801 nucleotide binding region [chemical binding]; other site 714359008802 ATP-binding site [chemical binding]; other site 714359008803 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 714359008804 DAK2 domain; Region: Dak2; cl03685 714359008805 Protein of unknown function (DUF322); Region: DUF322; cl00574 714359008806 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 714359008807 Thiamine pyrophosphokinase; Region: TPK; cd07995 714359008808 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 714359008809 active site 714359008810 dimerization interface [polypeptide binding]; other site 714359008811 thiamine binding site [chemical binding]; other site 714359008812 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 714359008813 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 714359008814 substrate binding site [chemical binding]; other site 714359008815 hexamer interface [polypeptide binding]; other site 714359008816 metal binding site [ion binding]; metal-binding site 714359008817 GTPase RsgA; Reviewed; Region: PRK00098 714359008818 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs...; Region: YjeQ_engC; cd01854 714359008819 GTPase/OB domain interface [polypeptide binding]; other site 714359008820 GTPase/Zn-binding domain interface [polypeptide binding]; other site 714359008821 GTP/Mg2+ binding site [chemical binding]; other site 714359008822 G4 box; other site 714359008823 G5 box; other site 714359008824 G1 box; other site 714359008825 Switch I region; other site 714359008826 G2 box; other site 714359008827 G3 box; other site 714359008828 Switch II region; other site 714359008829 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 714359008830 Catalytic domain of Protein Kinases; Region: PKc; cd00180 714359008831 active site 714359008832 ATP binding site [chemical binding]; other site 714359008833 substrate binding site [chemical binding]; other site 714359008834 activation loop (A-loop); other site 714359008835 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 714359008836 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 714359008837 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 714359008838 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 714359008839 Protein phosphatase 2C; Region: PP2C; pfam00481 714359008840 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 714359008841 active site 714359008842 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 714359008843 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359008844 FeS/SAM binding site; other site 714359008845 16S rRNA methyltransferase B; Provisional; Region: PRK14902 714359008846 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 714359008847 putative RNA binding site [nucleotide binding]; other site 714359008848 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359008849 S-adenosylmethionine binding site [chemical binding]; other site 714359008850 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 714359008851 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 714359008852 putative active site [active] 714359008853 substrate binding site [chemical binding]; other site 714359008854 putative cosubstrate binding site; other site 714359008855 catalytic site [active] 714359008856 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 714359008857 substrate binding site [chemical binding]; other site 714359008858 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 714359008859 active site 714359008860 catalytic residues [active] 714359008861 metal binding site [ion binding]; metal-binding site 714359008862 primosome assembly protein PriA; Validated; Region: PRK05580 714359008863 primosome assembly protein PriA; Validated; Region: PRK05580 714359008864 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714359008865 ATP binding site [chemical binding]; other site 714359008866 putative Mg++ binding site [ion binding]; other site 714359008867 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359008868 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 714359008869 Flavoprotein; Region: Flavoprotein; cl08021 714359008870 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 714359008871 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 714359008872 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 714359008873 catalytic site [active] 714359008874 G-X2-G-X-G-K; other site 714359008875 Domain of unknown function (DUF370); Region: DUF370; cl00898 714359008876 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 714359008877 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 714359008878 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 714359008879 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 714359008880 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 714359008881 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359008882 motif II; other site 714359008883 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 714359008884 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 714359008885 Domain of unknown function (DUF814); Region: DUF814; pfam05670 714359008886 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 714359008887 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 714359008888 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 714359008889 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 714359008890 active site 714359008891 DinB superfamily; Region: DinB_2; cl00986 714359008892 Na+/H+ antiporter family; Region: Na_H_antiporter; cl15356 714359008893 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 714359008894 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 714359008895 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 714359008896 active site 714359008897 dimer interface [polypeptide binding]; other site 714359008898 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 714359008899 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 714359008900 heterodimer interface [polypeptide binding]; other site 714359008901 active site 714359008902 FMN binding site [chemical binding]; other site 714359008903 homodimer interface [polypeptide binding]; other site 714359008904 substrate binding site [chemical binding]; other site 714359008905 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 714359008906 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 714359008907 FAD binding pocket [chemical binding]; other site 714359008908 FAD binding motif [chemical binding]; other site 714359008909 phosphate binding motif [ion binding]; other site 714359008910 beta-alpha-beta structure motif; other site 714359008911 NAD binding pocket [chemical binding]; other site 714359008912 Iron coordination center [ion binding]; other site 714359008913 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 714359008914 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 714359008915 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 714359008916 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 714359008917 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 714359008918 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 714359008919 IMP binding site; other site 714359008920 dimer interface [polypeptide binding]; other site 714359008921 interdomain contacts; other site 714359008922 partial ornithine binding site; other site 714359008923 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 714359008924 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 714359008925 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 714359008926 catalytic site [active] 714359008927 subunit interface [polypeptide binding]; other site 714359008928 dihydroorotase; Validated; Region: pyrC; PRK09357 714359008929 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 714359008930 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 714359008931 active site 714359008932 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 714359008933 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 714359008934 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359008935 Permease family; Region: Xan_ur_permease; cl00967 714359008936 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 714359008937 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 714359008938 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714359008939 RNA binding surface [nucleotide binding]; other site 714359008940 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 714359008941 active site 714359008942 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 714359008943 lipoprotein signal peptidase; Provisional; Region: PRK14787 714359008944 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 714359008945 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 714359008946 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 714359008947 active site 714359008948 HIGH motif; other site 714359008949 nucleotide binding site [chemical binding]; other site 714359008950 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 714359008951 active site 714359008952 KMSKS motif; other site 714359008953 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 714359008954 tRNA binding surface [nucleotide binding]; other site 714359008955 anticodon binding site; other site 714359008956 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 714359008957 DivIVA protein; Region: DivIVA; pfam05103 714359008958 DivIVA domain; Region: DivI1A_domain; TIGR03544 714359008959 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 714359008960 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 714359008961 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714359008962 RNA binding surface [nucleotide binding]; other site 714359008963 Protein of unknown function (DUF552); Region: DUF552; cl00775 714359008964 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 714359008965 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 714359008966 catalytic residue [active] 714359008967 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 714359008968 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 714359008969 sporulation sigma factor SigG; Reviewed; Region: PRK08215 714359008970 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359008971 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 714359008972 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714359008973 DNA binding residues [nucleotide binding] 714359008974 sporulation sigma factor SigE; Reviewed; Region: PRK08301 714359008975 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359008976 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714359008977 DNA binding residues [nucleotide binding] 714359008978 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 714359008979 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 714359008980 cell division protein FtsZ; Validated; Region: PRK09330 714359008981 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 714359008982 nucleotide binding site [chemical binding]; other site 714359008983 SulA interaction site; other site 714359008984 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 714359008985 Cell division protein FtsA; Region: FtsA; cl11496 714359008986 Cell division protein FtsA; Region: FtsA; cl11496 714359008987 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 714359008988 Cell division protein FtsQ; Region: FtsQ; pfam03799 714359008989 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 714359008990 FAD binding domain; Region: FAD_binding_4; pfam01565 714359008991 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 714359008992 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 714359008993 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 714359008994 active site 714359008995 homodimer interface [polypeptide binding]; other site 714359008996 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 714359008997 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 714359008998 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 714359008999 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 714359009000 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 714359009001 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 714359009002 Mg++ binding site [ion binding]; other site 714359009003 putative catalytic motif [active] 714359009004 putative substrate binding site [chemical binding]; other site 714359009005 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 714359009006 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 714359009007 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 714359009008 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 714359009009 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 714359009010 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 714359009011 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359009012 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 714359009013 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 714359009014 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 714359009015 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359009016 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 714359009017 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 714359009018 Septum formation initiator; Region: DivIC; cl11433 714359009019 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 714359009020 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 714359009021 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 714359009022 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 714359009023 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359009024 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 714359009025 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 714359009026 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359009027 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 714359009028 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 714359009029 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 714359009030 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 714359009031 hypothetical protein; Provisional; Region: PRK13670 714359009032 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 714359009033 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 714359009034 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 714359009035 protein binding site [polypeptide binding]; other site 714359009036 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 714359009037 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 714359009038 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 714359009039 active site 714359009040 nucleophile elbow; other site 714359009041 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 714359009042 Nucleoside recognition; Region: Gate; cl00486 714359009043 Nucleoside recognition; Region: Gate; cl00486 714359009044 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 714359009045 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 714359009046 active site 714359009047 (T/H)XGH motif; other site 714359009048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359009049 S-adenosylmethionine binding site [chemical binding]; other site 714359009050 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 714359009051 Protein of unknown function (DUF964); Region: DUF964; cl01483 714359009052 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 714359009053 catalytic core [active] 714359009054 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 714359009055 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 714359009056 YugN-like family; Region: YugN; pfam08868 714359009057 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 714359009058 multimer interface [polypeptide binding]; other site 714359009059 active site 714359009060 catalytic triad [active] 714359009061 dimer interface [polypeptide binding]; other site 714359009062 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 714359009063 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 714359009064 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 714359009065 Subunit I/III interface [polypeptide binding]; other site 714359009066 Subunit III/IV interface [polypeptide binding]; other site 714359009067 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 714359009068 Putative water exit pathway; other site 714359009069 Putative proton exit pathway; other site 714359009070 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 714359009071 D-pathway; other site 714359009072 Low-spin heme binding site [chemical binding]; other site 714359009073 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 714359009074 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 714359009075 Cytochrome c; Region: Cytochrom_C; cl11414 714359009076 UbiA prenyltransferase family; Region: UbiA; cl00337 714359009077 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 714359009078 pyruvate carboxylase; Reviewed; Region: PRK12999 714359009079 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 714359009080 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 714359009081 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 714359009082 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 714359009083 active site 714359009084 catalytic residues [active] 714359009085 metal binding site [ion binding]; metal-binding site 714359009086 homodimer binding site [polypeptide binding]; other site 714359009087 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 714359009088 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 714359009089 carboxyltransferase (CT) interaction site; other site 714359009090 biotinylation site [posttranslational modification]; other site 714359009091 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 714359009092 Protein of unknown function (DUF1507); Region: DUF1507; cl11487 714359009093 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 714359009094 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 714359009095 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 714359009096 putative active site [active] 714359009097 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359009098 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 714359009099 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; cl11558 714359009100 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 714359009101 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 714359009102 Switch I region; other site 714359009103 G2 box; other site 714359009104 putative GEF interaction site [polypeptide binding]; other site 714359009105 G3 box; other site 714359009106 Switch II region; other site 714359009107 GTP/Mg2+ binding site [chemical binding]; other site 714359009108 G4 box; other site 714359009109 G5 box; other site 714359009110 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 714359009111 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 714359009112 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 714359009113 active site 714359009114 Protein of unknown function (DUF1054); Region: DUF1054; cl11544 714359009115 Uncharacterised protein family (UPF0223); Region: UPF0223; cl11484 714359009116 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 714359009117 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 714359009118 homodimer interface [polypeptide binding]; other site 714359009119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359009120 catalytic residue [active] 714359009121 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 714359009122 transglutaminase; Provisional; Region: tgl; PRK03187 714359009123 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 714359009124 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 714359009125 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 714359009126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359009127 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 714359009128 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 714359009129 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 714359009130 E3 interaction surface; other site 714359009131 lipoyl attachment site [posttranslational modification]; other site 714359009132 e3 binding domain; Region: E3_binding; pfam02817 714359009133 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 714359009134 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 714359009135 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 714359009136 alpha subunit interface [polypeptide binding]; other site 714359009137 TPP binding site [chemical binding]; other site 714359009138 heterodimer interface [polypeptide binding]; other site 714359009139 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 714359009140 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 714359009141 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 714359009142 TPP-binding site [chemical binding]; other site 714359009143 heterodimer interface [polypeptide binding]; other site 714359009144 tetramer interface [polypeptide binding]; other site 714359009145 phosphorylation loop region [posttranslational modification] 714359009146 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 714359009147 active site 714359009148 catalytic residues [active] 714359009149 metal binding site [ion binding]; metal-binding site 714359009150 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359009151 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 714359009152 active site 714359009153 motif I; other site 714359009154 motif II; other site 714359009155 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 714359009156 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 714359009157 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 714359009158 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 714359009159 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 714359009160 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 714359009161 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359009162 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 714359009163 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 714359009164 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 714359009165 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 714359009166 metal binding site [ion binding]; metal-binding site 714359009167 putative dimer interface [polypeptide binding]; other site 714359009168 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapD_N; pfam08503 714359009169 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 714359009170 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 714359009171 trimer interface [polypeptide binding]; other site 714359009172 active site 714359009173 substrate binding site [chemical binding]; other site 714359009174 CoA binding site [chemical binding]; other site 714359009175 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714359009176 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359009177 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 714359009178 dimerization interface [polypeptide binding]; other site 714359009179 FOG: CBS domain [General function prediction only]; Region: COG0517 714359009180 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 714359009181 Protein of unknown function (DUF458); Region: DUF458; cl00861 714359009182 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 714359009183 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 714359009184 catalytic residues [active] 714359009185 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 714359009186 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 714359009187 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 714359009188 short chain dehydrogenase; Provisional; Region: PRK07677 714359009189 NAD(P) binding site [chemical binding]; other site 714359009190 substrate binding site [chemical binding]; other site 714359009191 homotetramer interface [polypeptide binding]; other site 714359009192 active site 714359009193 homodimer interface [polypeptide binding]; other site 714359009194 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 714359009195 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 714359009196 putative active site [active] 714359009197 putative metal binding site [ion binding]; other site 714359009198 Polyphosphate kinase; Region: PP_kinase; pfam02503 714359009199 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 714359009200 putative domain interface [polypeptide binding]; other site 714359009201 putative active site [active] 714359009202 catalytic site [active] 714359009203 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 714359009204 putative domain interface [polypeptide binding]; other site 714359009205 putative active site [active] 714359009206 catalytic site [active] 714359009207 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 714359009208 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 714359009209 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 714359009210 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 714359009211 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359009212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359009213 putative substrate translocation pore; other site 714359009214 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359009215 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 714359009216 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 714359009217 THF binding site; other site 714359009218 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 714359009219 substrate binding site [chemical binding]; other site 714359009220 THF binding site; other site 714359009221 zinc-binding site [ion binding]; other site 714359009222 Competence protein J (ComJ); Region: ComJ; pfam11033 714359009223 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 714359009224 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359009225 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359009226 dimer interface [polypeptide binding]; other site 714359009227 phosphorylation site [posttranslational modification] 714359009228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359009229 ATP binding site [chemical binding]; other site 714359009230 Mg2+ binding site [ion binding]; other site 714359009231 G-X-G motif; other site 714359009232 aminotransferase A; Validated; Region: PRK07683 714359009233 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714359009234 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359009235 homodimer interface [polypeptide binding]; other site 714359009236 catalytic residue [active] 714359009237 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 714359009238 DNA binding site [nucleotide binding] 714359009239 domain linker motif; other site 714359009240 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 714359009241 putative dimerization interface [polypeptide binding]; other site 714359009242 putative ligand binding site [chemical binding]; other site 714359009243 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 714359009244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359009245 dimer interface [polypeptide binding]; other site 714359009246 conserved gate region; other site 714359009247 putative PBP binding loops; other site 714359009248 ABC-ATPase subunit interface; other site 714359009249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359009250 dimer interface [polypeptide binding]; other site 714359009251 conserved gate region; other site 714359009252 putative PBP binding loops; other site 714359009253 ABC-ATPase subunit interface; other site 714359009254 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 714359009255 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 714359009256 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 714359009257 homodimer interface [polypeptide binding]; other site 714359009258 maltodextrin glucosidase; Provisional; Region: PRK10785 714359009259 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 714359009260 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 714359009261 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 714359009262 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 714359009263 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 714359009264 Walker A/P-loop; other site 714359009265 ATP binding site [chemical binding]; other site 714359009266 Q-loop/lid; other site 714359009267 ABC transporter signature motif; other site 714359009268 Walker B; other site 714359009269 D-loop; other site 714359009270 H-loop/switch region; other site 714359009271 TOBE domain; Region: TOBE_2; cl01440 714359009272 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359009273 NAD(P) binding site [chemical binding]; other site 714359009274 Predicted ATPase [General function prediction only]; Region: COG3910 714359009275 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359009276 Walker A/P-loop; other site 714359009277 ATP binding site [chemical binding]; other site 714359009278 Q-loop/lid; other site 714359009279 ABC transporter signature motif; other site 714359009280 Walker B; other site 714359009281 D-loop; other site 714359009282 H-loop/switch region; other site 714359009283 putative acyltransferase; Provisional; Region: PRK05790 714359009284 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 714359009285 dimer interface [polypeptide binding]; other site 714359009286 active site 714359009287 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 714359009288 nudix motif; other site 714359009289 hypothetical protein; Validated; Region: PRK07668 714359009290 hypothetical protein; Validated; Region: PRK07668 714359009291 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359009292 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359009293 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 714359009294 NAD(P) binding site [chemical binding]; other site 714359009295 active site 714359009296 YvrJ protein family; Region: YvrJ; pfam12841 714359009297 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 714359009298 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 714359009299 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 714359009300 Predicted amidohydrolase [General function prediction only]; Region: COG0388 714359009301 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 714359009302 putative active site [active] 714359009303 catalytic triad [active] 714359009304 putative dimer interface [polypeptide binding]; other site 714359009305 transaminase; Reviewed; Region: PRK08068 714359009306 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714359009307 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359009308 homodimer interface [polypeptide binding]; other site 714359009309 catalytic residue [active] 714359009310 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: salvage_mtnW; TIGR03332 714359009311 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 714359009312 dimer interface [polypeptide binding]; other site 714359009313 active site 714359009314 catalytic residue [active] 714359009315 metal binding site [ion binding]; metal-binding site 714359009316 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 714359009317 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 714359009318 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 714359009319 intersubunit interface [polypeptide binding]; other site 714359009320 active site 714359009321 Zn2+ binding site [ion binding]; other site 714359009322 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 714359009323 Cupin domain; Region: Cupin_2; cl09118 714359009324 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 714359009325 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359009326 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 714359009327 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359009328 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714359009329 metal binding site [ion binding]; metal-binding site 714359009330 active site 714359009331 I-site; other site 714359009332 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 714359009333 dimer interface [polypeptide binding]; other site 714359009334 FMN binding site [chemical binding]; other site 714359009335 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 714359009336 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 714359009337 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 714359009338 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 714359009339 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 714359009340 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 714359009341 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 714359009342 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 714359009343 active site turn [active] 714359009344 phosphorylation site [posttranslational modification] 714359009345 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 714359009346 HPr interaction site; other site 714359009347 glycerol kinase (GK) interaction site [polypeptide binding]; other site 714359009348 active site 714359009349 phosphorylation site [posttranslational modification] 714359009350 transcriptional antiterminator BglG; Provisional; Region: PRK09772 714359009351 CAT RNA binding domain; Region: CAT_RBD; cl03904 714359009352 PRD domain; Region: PRD; cl15445 714359009353 PRD domain; Region: PRD; cl15445 714359009354 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 714359009355 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359009356 active site 714359009357 motif I; other site 714359009358 motif II; other site 714359009359 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359009360 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359009361 DNA-binding site [nucleotide binding]; DNA binding site 714359009362 UTRA domain; Region: UTRA; cl01230 714359009363 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 714359009364 active site 714359009365 trimer interface [polypeptide binding]; other site 714359009366 allosteric site; other site 714359009367 active site lid [active] 714359009368 hexamer (dimer of trimers) interface [polypeptide binding]; other site 714359009369 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 714359009370 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 714359009371 active site 714359009372 dimer interface [polypeptide binding]; other site 714359009373 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 714359009374 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 714359009375 ScpA/B protein; Region: ScpA_ScpB; cl00598 714359009376 Domain of unknown function (DUF309); Region: DUF309; cl00667 714359009377 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359009378 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 714359009379 active site 714359009380 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 714359009381 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 714359009382 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 714359009383 active site 714359009384 motif I; other site 714359009385 motif II; other site 714359009386 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 714359009387 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 714359009388 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 714359009389 SpoVA protein; Region: SpoVA; cl04298 714359009390 stage V sporulation protein AD; Validated; Region: PRK08304 714359009391 stage V sporulation protein AD; Provisional; Region: PRK12404 714359009392 SpoVA protein; Region: SpoVA; cl04298 714359009393 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 714359009394 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 714359009395 sporulation sigma factor SigF; Validated; Region: PRK05572 714359009396 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359009397 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 714359009398 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714359009399 DNA binding residues [nucleotide binding] 714359009400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359009401 ATP binding site [chemical binding]; other site 714359009402 Mg2+ binding site [ion binding]; other site 714359009403 G-X-G motif; other site 714359009404 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 714359009405 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 714359009406 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359009407 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 714359009408 Predicted transcriptional regulators [Transcription]; Region: COG1725 714359009409 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359009410 DNA-binding site [nucleotide binding]; DNA binding site 714359009411 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 714359009412 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 714359009413 Walker A/P-loop; other site 714359009414 ATP binding site [chemical binding]; other site 714359009415 Q-loop/lid; other site 714359009416 ABC transporter signature motif; other site 714359009417 Walker B; other site 714359009418 D-loop; other site 714359009419 H-loop/switch region; other site 714359009420 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 714359009421 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 714359009422 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359009423 Protein of unknown function (DUF541); Region: SIMPL; cl01077 714359009424 Permease family; Region: Xan_ur_permease; cl00967 714359009425 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 714359009426 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 714359009427 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 714359009428 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 714359009429 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 714359009430 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 714359009431 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 714359009432 Sulfatase; Region: Sulfatase; cl10460 714359009433 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 714359009434 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 714359009435 Int/Topo IB signature motif; other site 714359009436 active site 714359009437 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 714359009438 metal binding site 2 [ion binding]; metal-binding site 714359009439 putative DNA binding helix; other site 714359009440 metal binding site 1 [ion binding]; metal-binding site 714359009441 dimer interface [polypeptide binding]; other site 714359009442 structural Zn2+ binding site [ion binding]; other site 714359009443 Integral membrane protein DUF95; Region: DUF95; cl00572 714359009444 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714359009445 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359009446 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 714359009447 dimer interface [polypeptide binding]; other site 714359009448 ADP-ribose binding site [chemical binding]; other site 714359009449 active site 714359009450 nudix motif; other site 714359009451 metal binding site [ion binding]; metal-binding site 714359009452 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 714359009453 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 714359009454 active site 714359009455 catalytic tetrad [active] 714359009456 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 714359009457 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 714359009458 active site 714359009459 catalytic tetrad [active] 714359009460 Uncharacterised protein family (UPF0157); Region: UPF0157; cl00987 714359009461 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 714359009462 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 714359009463 putative active site [active] 714359009464 putative metal binding site [ion binding]; other site 714359009465 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 714359009466 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 714359009467 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 714359009468 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359009469 Predicted permease [General function prediction only]; Region: COG2056 714359009470 Na+/H+ antiporter family; Region: Na_H_antiporter; cl15356 714359009471 Transcriptional regulators [Transcription]; Region: PurR; COG1609 714359009472 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 714359009473 DNA binding site [nucleotide binding] 714359009474 domain linker motif; other site 714359009475 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 714359009476 dimerization interface [polypeptide binding]; other site 714359009477 ligand binding site [chemical binding]; other site 714359009478 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 714359009479 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359009480 Coenzyme A binding pocket [chemical binding]; other site 714359009481 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359009482 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 714359009483 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 714359009484 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 714359009485 catalytic motif [active] 714359009486 Zn binding site [ion binding]; other site 714359009487 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 714359009488 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 714359009489 Lumazine binding domain; Region: Lum_binding; pfam00677 714359009490 Lumazine binding domain; Region: Lum_binding; pfam00677 714359009491 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 714359009492 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 714359009493 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 714359009494 dimerization interface [polypeptide binding]; other site 714359009495 active site 714359009496 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 714359009497 homopentamer interface [polypeptide binding]; other site 714359009498 active site 714359009499 biotin synthase; Validated; Region: PRK06256 714359009500 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359009501 FeS/SAM binding site; other site 714359009502 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 714359009503 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 714359009504 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359009505 S-adenosylmethionine binding site [chemical binding]; other site 714359009506 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359009507 Protein of unknown function (DUF452); Region: DUF452; cl01062 714359009508 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 714359009509 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 714359009510 substrate-cofactor binding pocket; other site 714359009511 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359009512 catalytic residue [active] 714359009513 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 714359009514 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359009515 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359009516 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 714359009517 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 714359009518 inhibitor-cofactor binding pocket; inhibition site 714359009519 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359009520 catalytic residue [active] 714359009521 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 714359009522 Na+/H+ antiporter family; Region: Na_H_antiporter; cl15356 714359009523 Na+/H+ antiporter family; Region: Na_H_antiporter; cl15356 714359009524 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09418 714359009525 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 714359009526 active site 714359009527 metal binding site [ion binding]; metal-binding site 714359009528 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 714359009529 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 714359009530 active site 714359009531 catalytic triad [active] 714359009532 oxyanion hole [active] 714359009533 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 714359009534 ornithine carbamoyltransferase; Provisional; Region: PRK00779 714359009535 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 714359009536 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359009537 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 714359009538 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 714359009539 inhibitor-cofactor binding pocket; inhibition site 714359009540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359009541 catalytic residue [active] 714359009542 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 714359009543 nucleotide binding site [chemical binding]; other site 714359009544 N-acetyl-L-glutamate binding site [chemical binding]; other site 714359009545 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 714359009546 heterotetramer interface [polypeptide binding]; other site 714359009547 active site pocket [active] 714359009548 cleavage site 714359009549 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 714359009550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359009551 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 714359009552 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 714359009553 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359009554 NAD(P) binding site [chemical binding]; other site 714359009555 active site 714359009556 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 714359009557 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359009558 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 714359009559 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 714359009560 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 714359009561 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 714359009562 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 714359009563 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 714359009564 putative L-serine binding site [chemical binding]; other site 714359009565 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 714359009566 magnesium-transporting ATPase; Provisional; Region: PRK15122 714359009567 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 714359009568 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 714359009569 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 714359009570 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 714359009571 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 714359009572 MgtC family; Region: MgtC; cl12207 714359009573 DNA polymerase IV; Validated; Region: PRK01810 714359009574 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 714359009575 active site 714359009576 DNA binding site [nucleotide binding] 714359009577 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 714359009578 peptidase T-like protein; Region: PepT-like; TIGR01883 714359009579 metal binding site [ion binding]; metal-binding site 714359009580 putative dimer interface [polypeptide binding]; other site 714359009581 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714359009582 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359009583 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 714359009584 Predicted membrane protein [Function unknown]; Region: COG4129 714359009585 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 714359009586 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 714359009587 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 714359009588 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 714359009589 Walker A/P-loop; other site 714359009590 ATP binding site [chemical binding]; other site 714359009591 Q-loop/lid; other site 714359009592 ABC transporter signature motif; other site 714359009593 Walker B; other site 714359009594 D-loop; other site 714359009595 H-loop/switch region; other site 714359009596 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 714359009597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359009598 dimer interface [polypeptide binding]; other site 714359009599 conserved gate region; other site 714359009600 putative PBP binding loops; other site 714359009601 ABC-ATPase subunit interface; other site 714359009602 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 714359009603 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714359009604 substrate binding pocket [chemical binding]; other site 714359009605 membrane-bound complex binding site; other site 714359009606 hinge residues; other site 714359009607 Protein of unknown function (DUF1094); Region: DUF1094; pfam06491 714359009608 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 714359009609 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 714359009610 nudix motif; other site 714359009611 Protein of unknown function (DUF421); Region: DUF421; cl00990 714359009612 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 714359009613 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 714359009614 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 714359009615 E3 interaction surface; other site 714359009616 lipoyl attachment site [posttranslational modification]; other site 714359009617 e3 binding domain; Region: E3_binding; pfam02817 714359009618 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 714359009619 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 714359009620 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 714359009621 alpha subunit interface [polypeptide binding]; other site 714359009622 TPP binding site [chemical binding]; other site 714359009623 heterodimer interface [polypeptide binding]; other site 714359009624 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 714359009625 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 714359009626 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 714359009627 tetramer interface [polypeptide binding]; other site 714359009628 TPP-binding site [chemical binding]; other site 714359009629 heterodimer interface [polypeptide binding]; other site 714359009630 phosphorylation loop region [posttranslational modification] 714359009631 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 714359009632 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359009633 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359009634 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 714359009635 Acetokinase family; Region: Acetate_kinase; cl01029 714359009636 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 714359009637 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 714359009638 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 714359009639 NAD binding site [chemical binding]; other site 714359009640 Phe binding site; other site 714359009641 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 714359009642 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 714359009643 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359009644 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 714359009645 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714359009646 putative active site [active] 714359009647 heme pocket [chemical binding]; other site 714359009648 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 714359009649 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359009650 Walker A motif; other site 714359009651 ATP binding site [chemical binding]; other site 714359009652 Walker B motif; other site 714359009653 arginine finger; other site 714359009654 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359009655 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 714359009656 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 714359009657 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 714359009658 active site 714359009659 catalytic site [active] 714359009660 metal binding site [ion binding]; metal-binding site 714359009661 dimer interface [polypeptide binding]; other site 714359009662 hypothetical protein; Provisional; Region: PRK06770 714359009663 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 714359009664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359009665 active site 714359009666 phosphorylation site [posttranslational modification] 714359009667 intermolecular recognition site; other site 714359009668 dimerization interface [polypeptide binding]; other site 714359009669 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 714359009670 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 714359009671 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 714359009672 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 714359009673 arginine repressor; Provisional; Region: PRK04280 714359009674 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 714359009675 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 714359009676 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714359009677 RNA binding surface [nucleotide binding]; other site 714359009678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 714359009679 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 714359009680 TPP-binding site [chemical binding]; other site 714359009681 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 714359009682 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 714359009683 PYR/PP interface [polypeptide binding]; other site 714359009684 dimer interface [polypeptide binding]; other site 714359009685 TPP binding site [chemical binding]; other site 714359009686 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 714359009687 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 714359009688 substrate binding pocket [chemical binding]; other site 714359009689 chain length determination region; other site 714359009690 substrate-Mg2+ binding site; other site 714359009691 catalytic residues [active] 714359009692 aspartate-rich region 1; other site 714359009693 active site lid residues [active] 714359009694 aspartate-rich region 2; other site 714359009695 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 714359009696 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 714359009697 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 714359009698 generic binding surface II; other site 714359009699 generic binding surface I; other site 714359009700 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 714359009701 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 714359009702 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 714359009703 homodimer interface [polypeptide binding]; other site 714359009704 NADP binding site [chemical binding]; other site 714359009705 substrate binding site [chemical binding]; other site 714359009706 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 714359009707 putative RNA binding site [nucleotide binding]; other site 714359009708 Protein of unknown function (DUF322); Region: DUF322; cl00574 714359009709 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 714359009710 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 714359009711 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 714359009712 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 714359009713 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 714359009714 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 714359009715 carboxyltransferase (CT) interaction site; other site 714359009716 biotinylation site [posttranslational modification]; other site 714359009717 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 714359009718 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 714359009719 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; cl09803 714359009720 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 714359009721 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 714359009722 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 714359009723 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 714359009724 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359009725 Walker A motif; other site 714359009726 ATP binding site [chemical binding]; other site 714359009727 Walker B motif; other site 714359009728 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 714359009729 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359009730 elongation factor P; Validated; Region: PRK00529 714359009731 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 714359009732 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 714359009733 RNA binding site [nucleotide binding]; other site 714359009734 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 714359009735 RNA binding site [nucleotide binding]; other site 714359009736 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 714359009737 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 714359009738 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 714359009739 active site 714359009740 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 714359009741 trimer interface [polypeptide binding]; other site 714359009742 active site 714359009743 dimer interface [polypeptide binding]; other site 714359009744 Conserved membrane protein YqhR; Region: YqhR; pfam11085 714359009745 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 714359009746 Carbon starvation protein CstA; Region: CstA; cl00856 714359009747 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 714359009748 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 714359009749 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359009750 motif II; other site 714359009751 manganese transport transcriptional regulator; Provisional; Region: PRK03902 714359009752 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359009753 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 714359009754 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 714359009755 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359009756 FeS/SAM binding site; other site 714359009757 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 714359009758 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 714359009759 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 714359009760 active site residue [active] 714359009761 Transcriptional regulators [Transcription]; Region: PurR; COG1609 714359009762 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 714359009763 DNA binding site [nucleotide binding] 714359009764 domain linker motif; other site 714359009765 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 714359009766 putative dimerization interface [polypeptide binding]; other site 714359009767 putative ligand binding site [chemical binding]; other site 714359009768 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359009769 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359009770 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 714359009771 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 714359009772 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 714359009773 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 714359009774 tetramer interface [polypeptide binding]; other site 714359009775 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359009776 catalytic residue [active] 714359009777 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 714359009778 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 714359009779 tetramer interface [polypeptide binding]; other site 714359009780 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359009781 catalytic residue [active] 714359009782 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 714359009783 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 714359009784 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 714359009785 DEAD-like helicases superfamily; Region: DEXDc; smart00487 714359009786 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714359009787 ATP binding site [chemical binding]; other site 714359009788 putative Mg++ binding site [ion binding]; other site 714359009789 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714359009790 nucleotide binding region [chemical binding]; other site 714359009791 ATP-binding site [chemical binding]; other site 714359009792 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 714359009793 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 714359009794 endonuclease III; Region: ENDO3c; smart00478 714359009795 minor groove reading motif; other site 714359009796 helix-hairpin-helix signature motif; other site 714359009797 substrate binding pocket [chemical binding]; other site 714359009798 active site 714359009799 A new structural DNA glycosylase; Region: AlkD_like; cd06561 714359009800 active site 714359009801 argininosuccinate lyase; Provisional; Region: PRK02186 714359009802 H+ Antiporter protein; Region: 2A0121; TIGR00900 714359009803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359009804 putative substrate translocation pore; other site 714359009805 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359009806 Radical SAM superfamily; Region: Radical_SAM; pfam04055 714359009807 FeS/SAM binding site; other site 714359009808 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 714359009809 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 714359009810 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 714359009811 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 714359009812 DNA binding site [nucleotide binding] 714359009813 active site 714359009814 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 714359009815 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 714359009816 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714359009817 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714359009818 hypothetical protein; Provisional; Region: PRK07206 714359009819 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 714359009820 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 714359009821 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 714359009822 Cupin domain; Region: Cupin_2; cl09118 714359009823 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359009824 S-adenosylmethionine binding site [chemical binding]; other site 714359009825 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359009826 sequence-specific DNA binding site [nucleotide binding]; other site 714359009827 salt bridge; other site 714359009828 shikimate kinase; Reviewed; Region: aroK; PRK00131 714359009829 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 714359009830 ADP binding site [chemical binding]; other site 714359009831 magnesium binding site [ion binding]; other site 714359009832 putative shikimate binding site; other site 714359009833 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 714359009834 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 714359009835 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 714359009836 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 714359009837 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 714359009838 Type II/IV secretion system protein; Region: GSPII_E; pfam00437 714359009839 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359009840 Walker A motif; other site 714359009841 ATP binding site [chemical binding]; other site 714359009842 Walker B motif; other site 714359009843 Predicted transcriptional regulator [Transcription]; Region: COG2345 714359009844 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359009845 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 714359009846 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 714359009847 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl01450 714359009848 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 714359009849 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 714359009850 active site 714359009851 homodimer interface [polypeptide binding]; other site 714359009852 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 714359009853 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 714359009854 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 714359009855 substrate binding pocket [chemical binding]; other site 714359009856 dimer interface [polypeptide binding]; other site 714359009857 inhibitor binding site; inhibition site 714359009858 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 714359009859 B12 binding site [chemical binding]; other site 714359009860 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 714359009861 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 714359009862 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 714359009863 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 714359009864 FAD binding site [chemical binding]; other site 714359009865 cystathionine gamma-synthase; Reviewed; Region: PRK08247 714359009866 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 714359009867 homodimer interface [polypeptide binding]; other site 714359009868 substrate-cofactor binding pocket; other site 714359009869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359009870 catalytic residue [active] 714359009871 cystathionine beta-lyase; Provisional; Region: PRK08064 714359009872 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 714359009873 homodimer interface [polypeptide binding]; other site 714359009874 substrate-cofactor binding pocket; other site 714359009875 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359009876 catalytic residue [active] 714359009877 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 714359009878 catalytic triad [active] 714359009879 conserved cis-peptide bond; other site 714359009880 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359009881 dimerization interface [polypeptide binding]; other site 714359009882 putative DNA binding site [nucleotide binding]; other site 714359009883 putative Zn2+ binding site [ion binding]; other site 714359009884 Uncharacterized conserved protein [Function unknown]; Region: COG1565 714359009885 Uncharacterized ACR, COG1565; Region: DUF185; pfam02636 714359009886 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 714359009887 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 714359009888 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 714359009889 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 714359009890 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 714359009891 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 714359009892 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 714359009893 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 714359009894 active site 714359009895 Substrate binding site; other site 714359009896 Mg++ binding site; other site 714359009897 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 714359009898 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 714359009899 active site 714359009900 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 714359009901 metal binding site [ion binding]; metal-binding site 714359009902 substrate binding site [chemical binding]; other site 714359009903 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 714359009904 PhoU domain; Region: PhoU; pfam01895 714359009905 PhoU domain; Region: PhoU; pfam01895 714359009906 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 714359009907 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 714359009908 Walker A/P-loop; other site 714359009909 ATP binding site [chemical binding]; other site 714359009910 Q-loop/lid; other site 714359009911 ABC transporter signature motif; other site 714359009912 Walker B; other site 714359009913 D-loop; other site 714359009914 H-loop/switch region; other site 714359009915 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 714359009916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359009917 dimer interface [polypeptide binding]; other site 714359009918 conserved gate region; other site 714359009919 putative PBP binding loops; other site 714359009920 ABC-ATPase subunit interface; other site 714359009921 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 714359009922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359009923 dimer interface [polypeptide binding]; other site 714359009924 conserved gate region; other site 714359009925 putative PBP binding loops; other site 714359009926 ABC-ATPase subunit interface; other site 714359009927 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 714359009928 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 714359009929 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 714359009930 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359009931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359009932 putative substrate translocation pore; other site 714359009933 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 714359009934 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 714359009935 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 714359009936 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 714359009937 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 714359009938 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694; cl15446 714359009939 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 714359009940 metal binding site 2 [ion binding]; metal-binding site 714359009941 putative DNA binding helix; other site 714359009942 metal binding site 1 [ion binding]; metal-binding site 714359009943 dimer interface [polypeptide binding]; other site 714359009944 structural Zn2+ binding site [ion binding]; other site 714359009945 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714359009946 ABC-ATPase subunit interface; other site 714359009947 dimer interface [polypeptide binding]; other site 714359009948 putative PBP binding regions; other site 714359009949 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 714359009950 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 714359009951 Uncharacterized conserved protein [Function unknown]; Region: COG1284 714359009952 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 714359009953 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 714359009954 endonuclease IV; Provisional; Region: PRK01060 714359009955 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 714359009956 AP (apurinic/apyrimidinic) site pocket; other site 714359009957 DNA interaction; other site 714359009958 Metal-binding active site; metal-binding site 714359009959 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 714359009960 DEAD-like helicases superfamily; Region: DEXDc; smart00487 714359009961 ATP binding site [chemical binding]; other site 714359009962 Mg++ binding site [ion binding]; other site 714359009963 motif III; other site 714359009964 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714359009965 nucleotide binding region [chemical binding]; other site 714359009966 ATP-binding site [chemical binding]; other site 714359009967 LytB protein; Region: LYTB; cl00507 714359009968 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 714359009969 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 714359009970 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 714359009971 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 714359009972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 714359009973 Cytochrome c; Region: Cytochrom_C; cl11414 714359009974 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 714359009975 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 714359009976 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 714359009977 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359009978 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 714359009979 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714359009980 DNA binding residues [nucleotide binding] 714359009981 DNA primase; Validated; Region: dnaG; PRK05667 714359009982 CHC2 zinc finger; Region: zf-CHC2; cl15369 714359009983 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 714359009984 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 714359009985 active site 714359009986 metal binding site [ion binding]; metal-binding site 714359009987 interdomain interaction site; other site 714359009988 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 714359009989 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 714359009990 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 714359009991 Domain of unknown function (DUF299); Region: DUF299; cl00780 714359009992 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 714359009993 FOG: CBS domain [General function prediction only]; Region: COG0517 714359009994 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 714359009995 Recombination protein O N terminal; Region: RecO_N; pfam11967 714359009996 Recombination protein O C terminal; Region: RecO_C; pfam02565 714359009997 GTPase Era; Reviewed; Region: era; PRK00089 714359009998 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit, possibly...; Region: Era; cd04163 714359009999 G1 box; other site 714359010000 GTP/Mg2+ binding site [chemical binding]; other site 714359010001 Switch I region; other site 714359010002 G2 box; other site 714359010003 Switch II region; other site 714359010004 G3 box; other site 714359010005 G4 box; other site 714359010006 G5 box; other site 714359010007 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 714359010008 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 714359010009 active site 714359010010 catalytic motif [active] 714359010011 Zn binding site [ion binding]; other site 714359010012 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 714359010013 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 714359010014 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 714359010015 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 714359010016 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 714359010017 Zn2+ binding site [ion binding]; other site 714359010018 Mg2+ binding site [ion binding]; other site 714359010019 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 714359010020 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359010021 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 714359010022 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 714359010023 YabP family; Region: YabP; cl06766 714359010024 GatB domain; Region: GatB_Yqey; cl11497 714359010025 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 714359010026 radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089 714359010027 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 714359010028 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359010029 FeS/SAM binding site; other site 714359010030 TRAM domain; Region: TRAM; cl01282 714359010031 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 714359010032 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 714359010033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359010034 S-adenosylmethionine binding site [chemical binding]; other site 714359010035 chaperone protein DnaJ; Provisional; Region: PRK14280 714359010036 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 714359010037 HSP70 interaction site [polypeptide binding]; other site 714359010038 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 714359010039 substrate binding site [polypeptide binding]; other site 714359010040 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 714359010041 Zn binding sites [ion binding]; other site 714359010042 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 714359010043 dimer interface [polypeptide binding]; other site 714359010044 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 714359010045 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 714359010046 dimer interface [polypeptide binding]; other site 714359010047 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 714359010048 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 714359010049 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359010050 HrcA protein C terminal domain; Region: HrcA; pfam01628 714359010051 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 714359010052 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359010053 FeS/SAM binding site; other site 714359010054 HemN C-terminal region; Region: HemN_C; pfam06969 714359010055 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359010056 GTP-binding protein LepA; Provisional; Region: PRK05433 714359010057 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 714359010058 G1 box; other site 714359010059 putative GEF interaction site [polypeptide binding]; other site 714359010060 GTP/Mg2+ binding site [chemical binding]; other site 714359010061 Switch I region; other site 714359010062 G2 box; other site 714359010063 G3 box; other site 714359010064 Switch II region; other site 714359010065 G4 box; other site 714359010066 G5 box; other site 714359010067 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 714359010068 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 714359010069 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 714359010070 Germination protease; Region: Peptidase_A25; cl04057 714359010071 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 714359010072 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 714359010073 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 714359010074 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 714359010075 Competence protein; Region: Competence; cl00471 714359010076 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 714359010077 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 714359010078 catalytic motif [active] 714359010079 Zn binding site [ion binding]; other site 714359010080 SLBB domain; Region: SLBB; pfam10531 714359010081 comEA protein; Region: comE; TIGR01259 714359010082 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 714359010083 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359010084 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 714359010085 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359010086 S-adenosylmethionine binding site [chemical binding]; other site 714359010087 Pro-kumamolisin, activation domain; Region: Pro-kuma_activ; cl07889 714359010088 Domain of unknown function DUF143; Region: DUF143; cl00519 714359010089 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 714359010090 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 714359010091 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 714359010092 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 714359010093 active site 714359010094 (T/H)XGH motif; other site 714359010095 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 714359010096 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 714359010097 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 714359010098 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 714359010099 shikimate binding site; other site 714359010100 NAD(P) binding site [chemical binding]; other site 714359010101 GTPase YqeH; Provisional; Region: PRK13796 714359010102 YqeH. YqeH is an essential GTP-binding protein. Depletion of YqeH induces an excess initiation of DNA replication, suggesting that it negatively controls initiation of chromosome replication. The YqeH subfamily is common in eukaryotes and sporadically...; Region: YqeH; cd01855 714359010103 GTP/Mg2+ binding site [chemical binding]; other site 714359010104 G4 box; other site 714359010105 G5 box; other site 714359010106 G1 box; other site 714359010107 Switch I region; other site 714359010108 G2 box; other site 714359010109 G3 box; other site 714359010110 Switch II region; other site 714359010111 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359010112 active site 714359010113 motif I; other site 714359010114 motif II; other site 714359010115 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 714359010116 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 714359010117 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359010118 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714359010119 DNA binding residues [nucleotide binding] 714359010120 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 714359010121 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 714359010122 dimer interface [polypeptide binding]; other site 714359010123 FMN binding site [chemical binding]; other site 714359010124 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 714359010125 synthetase active site [active] 714359010126 NTP binding site [chemical binding]; other site 714359010127 metal binding site [ion binding]; metal-binding site 714359010128 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 714359010129 dimer interface [polypeptide binding]; other site 714359010130 Alkaline phosphatase homologues; Region: alkPPc; smart00098 714359010131 active site 714359010132 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 714359010133 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359010134 Coenzyme A binding pocket [chemical binding]; other site 714359010135 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 714359010136 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359010137 CHAT domain; Region: CHAT; cl02083 714359010138 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 714359010139 catalytic core [active] 714359010140 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 714359010141 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 714359010142 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 714359010143 putative active site [active] 714359010144 catalytic triad [active] 714359010145 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 714359010146 putative integrin binding motif; other site 714359010147 PA/protease domain interface [polypeptide binding]; other site 714359010148 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 714359010149 Flagellar hook capping protein; Region: FlgD; cl04347 714359010150 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 714359010151 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 714359010152 cofactor binding site; other site 714359010153 metal binding site [ion binding]; metal-binding site 714359010154 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 714359010155 aromatic arch; other site 714359010156 DCoH dimer interaction site [polypeptide binding]; other site 714359010157 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 714359010158 DCoH tetramer interaction site [polypeptide binding]; other site 714359010159 substrate binding site [chemical binding]; other site 714359010160 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 714359010161 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 714359010162 putative metal binding site [ion binding]; other site 714359010163 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 714359010164 active site 714359010165 metal binding site [ion binding]; metal-binding site 714359010166 DoxX; Region: DoxX; cl00976 714359010167 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359010168 non-specific DNA binding site [nucleotide binding]; other site 714359010169 salt bridge; other site 714359010170 sequence-specific DNA binding site [nucleotide binding]; other site 714359010171 Cupin domain; Region: Cupin_2; cl09118 714359010172 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359010173 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714359010174 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359010175 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 714359010176 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 714359010177 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 714359010178 Walker A/P-loop; other site 714359010179 ATP binding site [chemical binding]; other site 714359010180 Q-loop/lid; other site 714359010181 ABC transporter signature motif; other site 714359010182 Walker B; other site 714359010183 D-loop; other site 714359010184 H-loop/switch region; other site 714359010185 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714359010186 ABC-ATPase subunit interface; other site 714359010187 dimer interface [polypeptide binding]; other site 714359010188 putative PBP binding regions; other site 714359010189 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 714359010190 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 714359010191 intersubunit interface [polypeptide binding]; other site 714359010192 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 714359010193 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 714359010194 putative catalytic cysteine [active] 714359010195 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 714359010196 putative active site [active] 714359010197 metal binding site [ion binding]; metal-binding site 714359010198 cystathionine beta-lyase; Provisional; Region: PRK07671 714359010199 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 714359010200 homodimer interface [polypeptide binding]; other site 714359010201 substrate-cofactor binding pocket; other site 714359010202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359010203 catalytic residue [active] 714359010204 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 714359010205 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 714359010206 dimer interface [polypeptide binding]; other site 714359010207 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359010208 catalytic residue [active] 714359010209 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 714359010210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359010211 S-adenosylmethionine binding site [chemical binding]; other site 714359010212 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 714359010213 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 714359010214 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 714359010215 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 714359010216 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359010217 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 714359010218 domain; Region: GreA_GreB_N; pfam03449 714359010219 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 714359010220 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 714359010221 ATP-binding site [chemical binding]; other site 714359010222 Sugar specificity; other site 714359010223 Pyrimidine base specificity; other site 714359010224 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 714359010225 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 714359010226 Peptidase family U32; Region: Peptidase_U32; cl03113 714359010227 Protein of unknown function (DUF556); Region: DUF556; cl00822 714359010228 Peptidase family U32; Region: Peptidase_U32; cl03113 714359010229 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 714359010230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359010231 S-adenosylmethionine binding site [chemical binding]; other site 714359010232 YceG-like family; Region: YceG; pfam02618 714359010233 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 714359010234 dimerization interface [polypeptide binding]; other site 714359010235 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 714359010236 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 714359010237 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 714359010238 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 714359010239 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 714359010240 motif 1; other site 714359010241 active site 714359010242 motif 2; other site 714359010243 motif 3; other site 714359010244 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 714359010245 DHHA1 domain; Region: DHHA1; pfam02272 714359010246 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 714359010247 Domain of unknown function DUF20; Region: UPF0118; cl00465 714359010248 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 714359010249 glutamyl-tRNA reductase; Region: hemA; TIGR01035 714359010250 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359010251 binding surface 714359010252 TPR motif; other site 714359010253 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 714359010254 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359010255 binding surface 714359010256 TPR motif; other site 714359010257 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 714359010258 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 714359010259 Ligand Binding Site [chemical binding]; other site 714359010260 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 714359010261 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 714359010262 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 714359010263 catalytic residue [active] 714359010264 Predicted transcriptional regulator [Transcription]; Region: COG1959 714359010265 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359010266 recombination factor protein RarA; Reviewed; Region: PRK13342 714359010267 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359010268 Walker A motif; other site 714359010269 ATP binding site [chemical binding]; other site 714359010270 Walker B motif; other site 714359010271 arginine finger; other site 714359010272 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 714359010273 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 714359010274 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 714359010275 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 714359010276 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 714359010277 putative ATP binding site [chemical binding]; other site 714359010278 putative substrate interface [chemical binding]; other site 714359010279 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 714359010280 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 714359010281 dimer interface [polypeptide binding]; other site 714359010282 anticodon binding site; other site 714359010283 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 714359010284 homodimer interface [polypeptide binding]; other site 714359010285 motif 1; other site 714359010286 active site 714359010287 motif 2; other site 714359010288 GAD domain; Region: GAD; pfam02938 714359010289 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 714359010290 motif 3; other site 714359010291 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 714359010292 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 714359010293 dimer interface [polypeptide binding]; other site 714359010294 motif 1; other site 714359010295 active site 714359010296 motif 2; other site 714359010297 motif 3; other site 714359010298 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 714359010299 anticodon binding site; other site 714359010300 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 714359010301 putative active site [active] 714359010302 dimerization interface [polypeptide binding]; other site 714359010303 putative tRNAtyr binding site [nucleotide binding]; other site 714359010304 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 714359010305 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 714359010306 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 714359010307 synthetase active site [active] 714359010308 NTP binding site [chemical binding]; other site 714359010309 metal binding site [ion binding]; metal-binding site 714359010310 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 714359010311 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 714359010312 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 714359010313 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 714359010314 DHH family; Region: DHH; pfam01368 714359010315 DHHA1 domain; Region: DHHA1; pfam02272 714359010316 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 714359010317 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 714359010318 Cation efflux family; Region: Cation_efflux; cl00316 714359010319 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 714359010320 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 714359010321 Protein export membrane protein; Region: SecD_SecF; cl14618 714359010322 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 714359010323 Protein export membrane protein; Region: SecD_SecF; cl14618 714359010324 stage V sporulation protein B; Region: spore_V_B; TIGR02900 714359010325 MatE; Region: MatE; cl10513 714359010326 MatE; Region: MatE; cl10513 714359010327 Protein of unknown function (DUF421); Region: DUF421; cl00990 714359010328 Preprotein translocase subunit; Region: YajC; cl00806 714359010329 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 714359010330 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 714359010331 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 714359010332 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 714359010333 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359010334 Walker A motif; other site 714359010335 ATP binding site [chemical binding]; other site 714359010336 Walker B motif; other site 714359010337 arginine finger; other site 714359010338 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 714359010339 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 714359010340 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 714359010341 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 714359010342 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 714359010343 putative ligand binding residues [chemical binding]; other site 714359010344 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 714359010345 BofC C-terminal domain; Region: BofC_C; pfam08955 714359010346 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 714359010347 Quinolinate synthetase A protein; Region: NadA; cl00420 714359010348 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 714359010349 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 714359010350 dimerization interface [polypeptide binding]; other site 714359010351 active site 714359010352 L-aspartate oxidase; Provisional; Region: PRK08071 714359010353 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359010354 domain; Region: Succ_DH_flav_C; pfam02910 714359010355 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 714359010356 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 714359010357 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 714359010358 catalytic residue [active] 714359010359 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 714359010360 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359010361 3H domain; Region: 3H; pfam02829 714359010362 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 714359010363 MOSC domain; Region: MOSC; pfam03473 714359010364 3-alpha domain; Region: 3-alpha; pfam03475 714359010365 prephenate dehydratase; Provisional; Region: PRK11898 714359010366 Prephenate dehydratase; Region: PDT; pfam00800 714359010367 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 714359010368 putative L-Phe binding site [chemical binding]; other site 714359010369 FtsX-like permease family; Region: FtsX; pfam02687 714359010370 FtsX-like permease family; Region: FtsX; pfam02687 714359010371 FtsX-like permease family; Region: FtsX; pfam02687 714359010372 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 714359010373 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 714359010374 Walker A/P-loop; other site 714359010375 ATP binding site [chemical binding]; other site 714359010376 Q-loop/lid; other site 714359010377 ABC transporter signature motif; other site 714359010378 Walker B; other site 714359010379 D-loop; other site 714359010380 H-loop/switch region; other site 714359010381 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 714359010382 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359010383 ATP binding site [chemical binding]; other site 714359010384 Mg2+ binding site [ion binding]; other site 714359010385 G-X-G motif; other site 714359010386 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359010387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359010388 active site 714359010389 phosphorylation site [posttranslational modification] 714359010390 intermolecular recognition site; other site 714359010391 dimerization interface [polypeptide binding]; other site 714359010392 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359010393 DNA binding site [nucleotide binding] 714359010394 GTPase CgtA; Reviewed; Region: obgE; PRK12297 714359010395 GTP1/OBG; Region: GTP1_OBG; pfam01018 714359010396 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 714359010397 G1 box; other site 714359010398 GTP/Mg2+ binding site [chemical binding]; other site 714359010399 Switch I region; other site 714359010400 G2 box; other site 714359010401 G3 box; other site 714359010402 Switch II region; other site 714359010403 G4 box; other site 714359010404 G5 box; other site 714359010405 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 714359010406 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 714359010407 Protein of unknown function (DUF464); Region: DUF464; cl01080 714359010408 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 714359010409 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 714359010410 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 714359010411 homodimer interface [polypeptide binding]; other site 714359010412 oligonucleotide binding site [chemical binding]; other site 714359010413 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 714359010414 putative substrate binding region [chemical binding]; other site 714359010415 Peptidase family M23; Region: Peptidase_M23; pfam01551 714359010416 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 714359010417 Switch II; other site 714359010418 septum formation inhibitor; Reviewed; Region: minC; PRK00513 714359010419 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 714359010420 rod shape-determining protein MreD; Region: MreD; cl01087 714359010421 chromosome segregation protein; Provisional; Region: PRK03918 714359010422 rod shape-determining protein MreC; Region: MreC; pfam04085 714359010423 rod shape-determining protein MreB; Provisional; Region: PRK13927 714359010424 Cell division protein FtsA; Region: FtsA; cl11496 714359010425 hypothetical protein; Reviewed; Region: PRK00024 714359010426 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 714359010427 MPN+ (JAMM) motif; other site 714359010428 Zinc-binding site [ion binding]; other site 714359010429 Maf-like protein; Region: Maf; pfam02545 714359010430 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 714359010431 active site 714359010432 dimer interface [polypeptide binding]; other site 714359010433 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 714359010434 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 714359010435 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 714359010436 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 714359010437 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 714359010438 active site 714359010439 HIGH motif; other site 714359010440 nucleotide binding site [chemical binding]; other site 714359010441 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 714359010442 active site 714359010443 KMSKS motif; other site 714359010444 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 714359010445 tRNA binding surface [nucleotide binding]; other site 714359010446 anticodon binding site; other site 714359010447 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 714359010448 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 714359010449 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 714359010450 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 714359010451 putative peptidoglycan binding site; other site 714359010452 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 714359010453 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 714359010454 inhibitor-cofactor binding pocket; inhibition site 714359010455 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359010456 catalytic residue [active] 714359010457 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 714359010458 dimer interface [polypeptide binding]; other site 714359010459 active site 714359010460 Schiff base residues; other site 714359010461 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 714359010462 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 714359010463 active site 714359010464 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 714359010465 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 714359010466 domain interfaces; other site 714359010467 active site 714359010468 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 714359010469 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 714359010470 tRNA; other site 714359010471 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 714359010472 putative NADP binding site [chemical binding]; other site 714359010473 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 714359010474 Transcriptional regulators [Transcription]; Region: MarR; COG1846 714359010475 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359010476 OsmC-like protein; Region: OsmC; cl00767 714359010477 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876 714359010478 G1 box; other site 714359010479 GTP/Mg2+ binding site [chemical binding]; other site 714359010480 Switch I region; other site 714359010481 G2 box; other site 714359010482 G3 box; other site 714359010483 Switch II region; other site 714359010484 G4 box; other site 714359010485 G5 box; other site 714359010486 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 714359010487 Found in ATP-dependent protease La (LON); Region: LON; smart00464 714359010488 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359010489 Walker A motif; other site 714359010490 ATP binding site [chemical binding]; other site 714359010491 Walker B motif; other site 714359010492 arginine finger; other site 714359010493 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 714359010494 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 714359010495 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359010496 Walker A motif; other site 714359010497 ATP binding site [chemical binding]; other site 714359010498 Walker B motif; other site 714359010499 arginine finger; other site 714359010500 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 714359010501 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 714359010502 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 714359010503 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359010504 Walker A motif; other site 714359010505 ATP binding site [chemical binding]; other site 714359010506 Walker B motif; other site 714359010507 arginine finger; other site 714359010508 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 714359010509 trigger factor; Provisional; Region: tig; PRK01490 714359010510 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 714359010511 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 714359010512 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 714359010513 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 714359010514 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 714359010515 active site 714359010516 metal binding site [ion binding]; metal-binding site 714359010517 homotetramer interface [polypeptide binding]; other site 714359010518 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 714359010519 active site 714359010520 dimerization interface [polypeptide binding]; other site 714359010521 ribonuclease PH; Reviewed; Region: rph; PRK00173 714359010522 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 714359010523 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 714359010524 Sporulation and spore germination; Region: Germane; cl11253 714359010525 Spore germination protein [General function prediction only]; Region: COG5401 714359010526 Sporulation and spore germination; Region: Germane; cl11253 714359010527 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 714359010528 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 714359010529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359010530 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 714359010531 potential catalytic triad [active] 714359010532 conserved cys residue [active] 714359010533 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359010534 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359010535 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 714359010536 potential catalytic triad [active] 714359010537 conserved cys residue [active] 714359010538 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714359010539 DNA binding residues [nucleotide binding] 714359010540 dimerization interface [polypeptide binding]; other site 714359010541 Permease family; Region: Xan_ur_permease; cl00967 714359010542 cytosine deaminase; Provisional; Region: PRK05985 714359010543 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 714359010544 active site 714359010545 PspC domain; Region: PspC; cl00864 714359010546 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359010547 non-specific DNA binding site [nucleotide binding]; other site 714359010548 salt bridge; other site 714359010549 sequence-specific DNA binding site [nucleotide binding]; other site 714359010550 Cupin domain; Region: Cupin_2; cl09118 714359010551 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 714359010552 amphipathic channel; other site 714359010553 Asn-Pro-Ala signature motifs; other site 714359010554 Predicted transcriptional regulator [Transcription]; Region: COG1959 714359010555 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359010556 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 714359010557 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 714359010558 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359010559 Walker A/P-loop; other site 714359010560 ATP binding site [chemical binding]; other site 714359010561 Q-loop/lid; other site 714359010562 ABC transporter signature motif; other site 714359010563 Walker B; other site 714359010564 D-loop; other site 714359010565 H-loop/switch region; other site 714359010566 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 714359010567 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 714359010568 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 714359010569 ligand binding site [chemical binding]; other site 714359010570 flagellar motor protein MotA; Validated; Region: PRK08124 714359010571 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 714359010572 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 714359010573 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 714359010574 active site 714359010575 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 714359010576 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 714359010577 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 714359010578 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359010579 domain; Region: Succ_DH_flav_C; pfam02910 714359010580 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 714359010581 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 714359010582 putative Iron-sulfur protein interface [polypeptide binding]; other site 714359010583 proximal heme binding site [chemical binding]; other site 714359010584 distal heme binding site [chemical binding]; other site 714359010585 putative dimer interface [polypeptide binding]; other site 714359010586 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 714359010587 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 714359010588 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 714359010589 active site 714359010590 catalytic site [active] 714359010591 putative DNA binding site [nucleotide binding]; other site 714359010592 GIY-YIG motif/motif A; other site 714359010593 metal binding site [ion binding]; metal-binding site 714359010594 UvrB/uvrC motif; Region: UVR; pfam02151 714359010595 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 714359010596 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 714359010597 catalytic residues [active] 714359010598 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 714359010599 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 714359010600 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 714359010601 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 714359010602 Ligand binding site [chemical binding]; other site 714359010603 Electron transfer flavoprotein domain; Region: ETF; pfam01012 714359010604 enoyl-CoA hydratase; Provisional; Region: PRK07658 714359010605 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 714359010606 substrate binding site [chemical binding]; other site 714359010607 oxyanion hole (OAH) forming residues; other site 714359010608 trimer interface [polypeptide binding]; other site 714359010609 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359010610 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359010611 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 714359010612 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 714359010613 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359010614 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359010615 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 714359010616 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 714359010617 siderophore binding site; other site 714359010618 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 714359010619 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714359010620 ABC-ATPase subunit interface; other site 714359010621 dimer interface [polypeptide binding]; other site 714359010622 putative PBP binding regions; other site 714359010623 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714359010624 ABC-ATPase subunit interface; other site 714359010625 dimer interface [polypeptide binding]; other site 714359010626 putative PBP binding regions; other site 714359010627 DinB superfamily; Region: DinB_2; cl00986 714359010628 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 714359010629 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 714359010630 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 714359010631 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 714359010632 Walker A/P-loop; other site 714359010633 ATP binding site [chemical binding]; other site 714359010634 Q-loop/lid; other site 714359010635 ABC transporter signature motif; other site 714359010636 Walker B; other site 714359010637 D-loop; other site 714359010638 H-loop/switch region; other site 714359010639 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359010640 dimer interface [polypeptide binding]; other site 714359010641 phosphorylation site [posttranslational modification] 714359010642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359010643 ATP binding site [chemical binding]; other site 714359010644 Mg2+ binding site [ion binding]; other site 714359010645 G-X-G motif; other site 714359010646 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359010647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359010648 active site 714359010649 phosphorylation site [posttranslational modification] 714359010650 intermolecular recognition site; other site 714359010651 dimerization interface [polypeptide binding]; other site 714359010652 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359010653 DNA binding site [nucleotide binding] 714359010654 Uncharacterized conserved protein (DUF2196); Region: DUF2196; cl02044 714359010655 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 714359010656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 714359010657 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 714359010658 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 714359010659 active site 714359010660 catalytic site [active] 714359010661 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 714359010662 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 714359010663 Walker A/P-loop; other site 714359010664 ATP binding site [chemical binding]; other site 714359010665 Q-loop/lid; other site 714359010666 ABC transporter signature motif; other site 714359010667 Walker B; other site 714359010668 D-loop; other site 714359010669 H-loop/switch region; other site 714359010670 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 714359010671 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714359010672 ABC-ATPase subunit interface; other site 714359010673 dimer interface [polypeptide binding]; other site 714359010674 putative PBP binding regions; other site 714359010675 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 714359010676 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 714359010677 intersubunit interface [polypeptide binding]; other site 714359010678 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 714359010679 heme-binding site [chemical binding]; other site 714359010680 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 714359010681 heme-binding site [chemical binding]; other site 714359010682 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 714359010683 heme-binding site [chemical binding]; other site 714359010684 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 714359010685 heme-binding site [chemical binding]; other site 714359010686 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 714359010687 heme-binding site [chemical binding]; other site 714359010688 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 714359010689 heme-binding site [chemical binding]; other site 714359010690 heme uptake protein IsdC; Region: IsdC; TIGR03656 714359010691 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 714359010692 heme-binding site [chemical binding]; other site 714359010693 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 714359010694 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 714359010695 PseudoU_synth_RluF_like: Pseudouridine synthase, Escherichia coli RluF like. This group is comprised of bacterial proteins similar to Escherichia coli RluF. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluF; cd02554 714359010696 pseudouridine synthase; Region: TIGR00093 714359010697 probable active site [active] 714359010698 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 714359010699 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 714359010700 Walker A/P-loop; other site 714359010701 ATP binding site [chemical binding]; other site 714359010702 Q-loop/lid; other site 714359010703 ABC transporter signature motif; other site 714359010704 Walker B; other site 714359010705 D-loop; other site 714359010706 H-loop/switch region; other site 714359010707 Smr domain; Region: Smr; cl02619 714359010708 hypothetical protein; Provisional; Region: PRK08609 714359010709 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 714359010710 active site 714359010711 primer binding site [nucleotide binding]; other site 714359010712 NTP binding site [chemical binding]; other site 714359010713 metal binding triad [ion binding]; metal-binding site 714359010714 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 714359010715 Colicin V production protein; Region: Colicin_V; cl00567 714359010716 Cell division protein ZapA; Region: ZapA; cl01146 714359010717 ribonuclease HIII; Provisional; Region: PRK00996 714359010718 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 714359010719 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 714359010720 RNA/DNA hybrid binding site [nucleotide binding]; other site 714359010721 active site 714359010722 short chain dehydrogenase; Provisional; Region: PRK06197 714359010723 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 714359010724 putative NAD(P) binding site [chemical binding]; other site 714359010725 active site 714359010726 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 714359010727 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 714359010728 putative dimer interface [polypeptide binding]; other site 714359010729 putative anticodon binding site; other site 714359010730 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 714359010731 homodimer interface [polypeptide binding]; other site 714359010732 motif 1; other site 714359010733 motif 2; other site 714359010734 active site 714359010735 motif 3; other site 714359010736 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 714359010737 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 714359010738 putative tRNA-binding site [nucleotide binding]; other site 714359010739 B3/4 domain; Region: B3_4; cl11458 714359010740 tRNA synthetase B5 domain; Region: B5; cl08394 714359010741 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 714359010742 dimer interface [polypeptide binding]; other site 714359010743 motif 1; other site 714359010744 motif 3; other site 714359010745 motif 2; other site 714359010746 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 714359010747 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 714359010748 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 714359010749 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 714359010750 dimer interface [polypeptide binding]; other site 714359010751 motif 1; other site 714359010752 active site 714359010753 motif 2; other site 714359010754 motif 3; other site 714359010755 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 714359010756 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 714359010757 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 714359010758 small acid-soluble spore protein SspI; Provisional; Region: PRK02955; cl07940 714359010759 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 714359010760 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 714359010761 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 714359010762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359010763 putative substrate translocation pore; other site 714359010764 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359010765 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 714359010766 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359010767 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359010768 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 714359010769 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 714359010770 oligomer interface [polypeptide binding]; other site 714359010771 active site 714359010772 metal binding site [ion binding]; metal-binding site 714359010773 Dimeric dUTPase [Carbohydrate transport and metabolism]; Region: COG4508 714359010774 dUTPase; Region: dUTPase_2; pfam08761 714359010775 ribosomal protein L20; Region: rpl20; CHL00068 714359010776 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 714359010777 23S rRNA binding site [nucleotide binding]; other site 714359010778 L21 binding site [polypeptide binding]; other site 714359010779 L13 binding site [polypeptide binding]; other site 714359010780 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 714359010781 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 714359010782 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 714359010783 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 714359010784 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 714359010785 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 714359010786 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 714359010787 active site 714359010788 dimer interface [polypeptide binding]; other site 714359010789 motif 1; other site 714359010790 motif 2; other site 714359010791 motif 3; other site 714359010792 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 714359010793 anticodon binding site; other site 714359010794 YtxC-like family; Region: YtxC; cl08500 714359010795 primosomal protein DnaI; Reviewed; Region: PRK08939 714359010796 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 714359010797 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359010798 Walker A motif; other site 714359010799 ATP binding site [chemical binding]; other site 714359010800 Walker B motif; other site 714359010801 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 714359010802 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 714359010803 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 714359010804 ATP cone domain; Region: ATP-cone; pfam03477 714359010805 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 714359010806 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 714359010807 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 714359010808 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 714359010809 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 714359010810 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 714359010811 CoA-binding site [chemical binding]; other site 714359010812 ATP-binding [chemical binding]; other site 714359010813 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 714359010814 Domain of unknown function DUF; Region: DUF204; pfam02659 714359010815 Domain of unknown function DUF; Region: DUF204; pfam02659 714359010816 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 714359010817 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 714359010818 DNA binding site [nucleotide binding] 714359010819 catalytic residue [active] 714359010820 H2TH interface [polypeptide binding]; other site 714359010821 putative catalytic residues [active] 714359010822 turnover-facilitating residue; other site 714359010823 intercalation triad [nucleotide binding]; other site 714359010824 8OG recognition residue [nucleotide binding]; other site 714359010825 putative reading head residues; other site 714359010826 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 714359010827 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 714359010828 DNA polymerase I; Provisional; Region: PRK05755 714359010829 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 714359010830 active site 714359010831 metal binding site 1 [ion binding]; metal-binding site 714359010832 putative 5' ssDNA interaction site; other site 714359010833 metal binding site 3; metal-binding site 714359010834 metal binding site 2 [ion binding]; metal-binding site 714359010835 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 714359010836 putative DNA binding site [nucleotide binding]; other site 714359010837 putative metal binding site [ion binding]; other site 714359010838 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 714359010839 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 714359010840 active site 714359010841 DNA binding site [nucleotide binding] 714359010842 catalytic site [active] 714359010843 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 714359010844 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 714359010845 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714359010846 putative active site [active] 714359010847 heme pocket [chemical binding]; other site 714359010848 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359010849 dimer interface [polypeptide binding]; other site 714359010850 phosphorylation site [posttranslational modification] 714359010851 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359010852 ATP binding site [chemical binding]; other site 714359010853 Mg2+ binding site [ion binding]; other site 714359010854 G-X-G motif; other site 714359010855 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359010856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359010857 active site 714359010858 phosphorylation site [posttranslational modification] 714359010859 intermolecular recognition site; other site 714359010860 dimerization interface [polypeptide binding]; other site 714359010861 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359010862 DNA binding site [nucleotide binding] 714359010863 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 714359010864 dimer interaction site [polypeptide binding]; other site 714359010865 substrate-binding tunnel; other site 714359010866 active site 714359010867 catalytic site [active] 714359010868 substrate binding site [chemical binding]; other site 714359010869 malate dehydrogenase; Reviewed; Region: PRK06223 714359010870 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 714359010871 NAD(P) binding site [chemical binding]; other site 714359010872 dimer interface [polypeptide binding]; other site 714359010873 tetramer (dimer of dimers) interface [polypeptide binding]; other site 714359010874 substrate binding site [chemical binding]; other site 714359010875 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 714359010876 isocitrate dehydrogenase; Validated; Region: PRK07362 714359010877 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 714359010878 dimer interface [polypeptide binding]; other site 714359010879 Citrate synthase; Region: Citrate_synt; pfam00285 714359010880 active site 714359010881 citrylCoA binding site [chemical binding]; other site 714359010882 oxalacetate/citrate binding site [chemical binding]; other site 714359010883 coenzyme A binding site [chemical binding]; other site 714359010884 catalytic triad [active] 714359010885 Protein of unknown function (DUF441); Region: DUF441; cl01041 714359010886 Domain of unknown function DUF20; Region: UPF0118; cl00465 714359010887 pyruvate kinase; Provisional; Region: PRK06354 714359010888 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 714359010889 domain interfaces; other site 714359010890 active site 714359010891 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 714359010892 6-phosphofructokinase; Provisional; Region: PRK03202 714359010893 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 714359010894 active site 714359010895 ADP/pyrophosphate binding site [chemical binding]; other site 714359010896 dimerization interface [polypeptide binding]; other site 714359010897 allosteric effector site; other site 714359010898 fructose-1,6-bisphosphate binding site; other site 714359010899 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 714359010900 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 714359010901 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 714359010902 Transcriptional regulators [Transcription]; Region: FadR; COG2186 714359010903 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359010904 DNA-binding site [nucleotide binding]; DNA binding site 714359010905 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 714359010906 Malic enzyme, N-terminal domain; Region: malic; pfam00390 714359010907 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 714359010908 putative NAD(P) binding site [chemical binding]; other site 714359010909 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 714359010910 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 714359010911 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 714359010912 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 714359010913 generic binding surface II; other site 714359010914 generic binding surface I; other site 714359010915 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 714359010916 DHH family; Region: DHH; pfam01368 714359010917 DHHA1 domain; Region: DHHA1; pfam02272 714359010918 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 714359010919 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359010920 DNA-binding site [nucleotide binding]; DNA binding site 714359010921 DRTGG domain; Region: DRTGG; cl12147 714359010922 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 714359010923 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 714359010924 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 714359010925 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 714359010926 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 714359010927 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 714359010928 active site 714359010929 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 714359010930 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 714359010931 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359010932 Coenzyme A binding pocket [chemical binding]; other site 714359010933 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359010934 Cupin domain; Region: Cupin_2; cl09118 714359010935 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 714359010936 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 714359010937 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359010938 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 714359010939 classical (c) SDRs; Region: SDR_c; cd05233 714359010940 NAD(P) binding site [chemical binding]; other site 714359010941 active site 714359010942 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 714359010943 Ligand Binding Site [chemical binding]; other site 714359010944 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 714359010945 argininosuccinate lyase; Provisional; Region: PRK00855 714359010946 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 714359010947 active sites [active] 714359010948 tetramer interface [polypeptide binding]; other site 714359010949 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 714359010950 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 714359010951 ANP binding site [chemical binding]; other site 714359010952 Substrate Binding Site II [chemical binding]; other site 714359010953 Substrate Binding Site I [chemical binding]; other site 714359010954 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 714359010955 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 714359010956 EcsC protein family; Region: EcsC; pfam12787 714359010957 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 714359010958 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 714359010959 nudix motif; other site 714359010960 Acetokinase family; Region: Acetate_kinase; cl01029 714359010961 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 714359010962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359010963 S-adenosylmethionine binding site [chemical binding]; other site 714359010964 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 714359010965 dimer interface [polypeptide binding]; other site 714359010966 catalytic triad [active] 714359010967 peroxidatic and resolving cysteines [active] 714359010968 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 714359010969 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 714359010970 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 714359010971 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 714359010972 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 714359010973 active site 714359010974 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 714359010975 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 714359010976 dimer interface [polypeptide binding]; other site 714359010977 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 714359010978 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359010979 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359010980 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 714359010981 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 714359010982 THUMP domain; Region: THUMP; cl12076 714359010983 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 714359010984 Ligand Binding Site [chemical binding]; other site 714359010985 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 714359010986 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 714359010987 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 714359010988 catalytic residue [active] 714359010989 septation ring formation regulator EzrA; Provisional; Region: PRK04778 714359010990 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714359010991 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359010992 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 714359010993 dimerization interface [polypeptide binding]; other site 714359010994 EamA-like transporter family; Region: EamA; cl01037 714359010995 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 714359010996 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359010997 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359010998 GAF domain; Region: GAF; cl00853 714359010999 methionine gamma-lyase; Provisional; Region: PRK06767 714359011000 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 714359011001 homodimer interface [polypeptide binding]; other site 714359011002 substrate-cofactor binding pocket; other site 714359011003 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359011004 catalytic residue [active] 714359011005 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 714359011006 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 714359011007 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714359011008 RNA binding surface [nucleotide binding]; other site 714359011009 Bacillus transposase protein; Region: Transposase_30; pfam04740 714359011010 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 714359011011 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 714359011012 active site 714359011013 HIGH motif; other site 714359011014 dimer interface [polypeptide binding]; other site 714359011015 KMSKS motif; other site 714359011016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714359011017 RNA binding surface [nucleotide binding]; other site 714359011018 maltose O-acetyltransferase; Provisional; Region: PRK10092 714359011019 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 714359011020 active site 714359011021 substrate binding site [chemical binding]; other site 714359011022 trimer interface [polypeptide binding]; other site 714359011023 CoA binding site [chemical binding]; other site 714359011024 acetyl-CoA synthetase; Provisional; Region: PRK04319 714359011025 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 714359011026 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359011027 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359011028 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359011029 FOG: CBS domain [General function prediction only]; Region: COG0517 714359011030 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 714359011031 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 714359011032 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 714359011033 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 714359011034 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359011035 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359011036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359011037 active site 714359011038 phosphorylation site [posttranslational modification] 714359011039 intermolecular recognition site; other site 714359011040 dimerization interface [polypeptide binding]; other site 714359011041 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359011042 DNA binding site [nucleotide binding] 714359011043 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359011044 dimerization interface [polypeptide binding]; other site 714359011045 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359011046 dimer interface [polypeptide binding]; other site 714359011047 phosphorylation site [posttranslational modification] 714359011048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359011049 ATP binding site [chemical binding]; other site 714359011050 Mg2+ binding site [ion binding]; other site 714359011051 G-X-G motif; other site 714359011052 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 714359011053 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 714359011054 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 714359011055 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 714359011056 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359011057 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 714359011058 catabolite control protein A; Region: ccpA; TIGR01481 714359011059 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 714359011060 DNA binding site [nucleotide binding] 714359011061 domain linker motif; other site 714359011062 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 714359011063 dimerization interface [polypeptide binding]; other site 714359011064 effector binding site; other site 714359011065 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 714359011066 Chorismate mutase type II; Region: CM_2; cl00693 714359011067 NeuB family; Region: NeuB; cl00496 714359011068 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 714359011069 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 714359011070 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 714359011071 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 714359011072 Protein of unknown function (DUF1200); Region: DUF1200; pfam06713 714359011073 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714359011074 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 714359011075 Coenzyme A binding pocket [chemical binding]; other site 714359011076 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359011077 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359011078 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 714359011079 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 714359011080 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 714359011081 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 714359011082 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 714359011083 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 714359011084 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 714359011085 active site 714359011086 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359011087 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 714359011088 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 714359011089 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 714359011090 active site 714359011091 metal binding site [ion binding]; metal-binding site 714359011092 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 714359011093 putative tRNA-binding site [nucleotide binding]; other site 714359011094 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 714359011095 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 714359011096 catalytic residues [active] 714359011097 Protein of unknown function DUF84; Region: NTPase_I-T; cl00866 714359011098 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 714359011099 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 714359011100 oligomer interface [polypeptide binding]; other site 714359011101 active site 714359011102 metal binding site [ion binding]; metal-binding site 714359011103 Predicted small secreted protein [Function unknown]; Region: COG5584 714359011104 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 714359011105 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 714359011106 Phosphotransferase enzyme family; Region: APH; pfam01636 714359011107 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 714359011108 active site 714359011109 substrate binding site [chemical binding]; other site 714359011110 ATP binding site [chemical binding]; other site 714359011111 pullulanase, type I; Region: pulA_typeI; TIGR02104 714359011112 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 714359011113 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 714359011114 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 714359011115 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 714359011116 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 714359011117 dipeptidase PepV; Reviewed; Region: PRK07318 714359011118 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 714359011119 active site 714359011120 metal binding site [ion binding]; metal-binding site 714359011121 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 714359011122 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714359011123 RNA binding surface [nucleotide binding]; other site 714359011124 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 714359011125 active site 714359011126 uracil binding [chemical binding]; other site 714359011127 stage V sporulation protein B; Region: spore_V_B; TIGR02900 714359011128 MatE; Region: MatE; cl10513 714359011129 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359011130 flavoprotein, HI0933 family; Region: TIGR00275 714359011131 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 714359011132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359011133 putative substrate translocation pore; other site 714359011134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359011135 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359011136 dimerization interface [polypeptide binding]; other site 714359011137 putative DNA binding site [nucleotide binding]; other site 714359011138 putative Zn2+ binding site [ion binding]; other site 714359011139 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 714359011140 putative hydrophobic ligand binding site [chemical binding]; other site 714359011141 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 714359011142 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 714359011143 glucose-1-dehydrogenase; Provisional; Region: PRK08936 714359011144 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 714359011145 NAD binding site [chemical binding]; other site 714359011146 homodimer interface [polypeptide binding]; other site 714359011147 active site 714359011148 Sugar transport protein; Region: Sugar_transport; pfam06800 714359011149 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 714359011150 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 714359011151 MoaE interaction surface [polypeptide binding]; other site 714359011152 MoeB interaction surface [polypeptide binding]; other site 714359011153 thiocarboxylated glycine; other site 714359011154 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 714359011155 MoaE homodimer interface [polypeptide binding]; other site 714359011156 MoaD interaction [polypeptide binding]; other site 714359011157 active site residues [active] 714359011158 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 714359011159 Walker A motif; other site 714359011160 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 714359011161 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 714359011162 dimer interface [polypeptide binding]; other site 714359011163 putative functional site; other site 714359011164 putative MPT binding site; other site 714359011165 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 714359011166 trimer interface [polypeptide binding]; other site 714359011167 dimer interface [polypeptide binding]; other site 714359011168 putative active site [active] 714359011169 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 714359011170 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 714359011171 ATP binding site [chemical binding]; other site 714359011172 substrate interface [chemical binding]; other site 714359011173 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 714359011174 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359011175 FeS/SAM binding site; other site 714359011176 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 714359011177 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 714359011178 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 714359011179 active site residue [active] 714359011180 homoserine O-acetyltransferase; Provisional; Region: metX; cl15472 714359011181 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 714359011182 Amino acid permease; Region: AA_permease; cl00524 714359011183 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 714359011184 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 714359011185 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 714359011186 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 714359011187 HIGH motif; other site 714359011188 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 714359011189 active site 714359011190 KMSKS motif; other site 714359011191 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 714359011192 tRNA binding surface [nucleotide binding]; other site 714359011193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359011194 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359011195 putative substrate translocation pore; other site 714359011196 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 714359011197 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 714359011198 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 714359011199 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 714359011200 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 714359011201 Phage integrase family; Region: Phage_integrase; pfam00589 714359011202 Int/Topo IB signature motif; other site 714359011203 FtsX-like permease family; Region: FtsX; pfam02687 714359011204 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 714359011205 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 714359011206 Walker A/P-loop; other site 714359011207 ATP binding site [chemical binding]; other site 714359011208 Q-loop/lid; other site 714359011209 ABC transporter signature motif; other site 714359011210 Walker B; other site 714359011211 D-loop; other site 714359011212 H-loop/switch region; other site 714359011213 Predicted membrane protein [Function unknown]; Region: COG2311 714359011214 Protein of unknown function (DUF418); Region: DUF418; cl12135 714359011215 Protein of unknown function (DUF418); Region: DUF418; cl12135 714359011216 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 714359011217 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 714359011218 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359011219 FeS/SAM binding site; other site 714359011220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 714359011221 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 714359011222 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 714359011223 aspartate racemase; Region: asp_race; TIGR00035 714359011224 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 714359011225 PepSY-associated TM helix; Region: PepSY_TM; pfam03929 714359011226 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 714359011227 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 714359011228 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 714359011229 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 714359011230 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 714359011231 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 714359011232 trimer interface [polypeptide binding]; other site 714359011233 putative metal binding site [ion binding]; other site 714359011234 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 714359011235 active site 714359011236 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 714359011237 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 714359011238 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 714359011239 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 714359011240 GTP binding site; other site 714359011241 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 714359011242 MPT binding site; other site 714359011243 trimer interface [polypeptide binding]; other site 714359011244 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714359011245 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359011246 S-adenosylmethionine synthetase; Validated; Region: PRK05250 714359011247 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 714359011248 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 714359011249 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 714359011250 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 714359011251 active site 714359011252 substrate-binding site [chemical binding]; other site 714359011253 metal-binding site [ion binding] 714359011254 ATP binding site [chemical binding]; other site 714359011255 EamA-like transporter family; Region: EamA; cl01037 714359011256 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 714359011257 EamA-like transporter family; Region: EamA; cl01037 714359011258 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 714359011259 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 714359011260 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 714359011261 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359011262 motif II; other site 714359011263 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 714359011264 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359011265 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 714359011266 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 714359011267 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359011268 motif II; other site 714359011269 sensor protein ZraS; Provisional; Region: PRK10364 714359011270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359011271 ATP binding site [chemical binding]; other site 714359011272 Mg2+ binding site [ion binding]; other site 714359011273 G-X-G motif; other site 714359011274 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 714359011275 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359011276 dimer interface [polypeptide binding]; other site 714359011277 phosphorylation site [posttranslational modification] 714359011278 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359011279 ATP binding site [chemical binding]; other site 714359011280 Mg2+ binding site [ion binding]; other site 714359011281 G-X-G motif; other site 714359011282 hydroperoxidase II; Provisional; Region: katE; PRK11249 714359011283 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 714359011284 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359011285 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 714359011286 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 714359011287 Sulfatase; Region: Sulfatase; cl10460 714359011288 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 714359011289 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 714359011290 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 714359011291 Walker A/P-loop; other site 714359011292 ATP binding site [chemical binding]; other site 714359011293 Q-loop/lid; other site 714359011294 ABC transporter signature motif; other site 714359011295 Walker B; other site 714359011296 D-loop; other site 714359011297 H-loop/switch region; other site 714359011298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359011299 dimer interface [polypeptide binding]; other site 714359011300 conserved gate region; other site 714359011301 putative PBP binding loops; other site 714359011302 ABC-ATPase subunit interface; other site 714359011303 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 714359011304 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 714359011305 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 714359011306 nudix motif; other site 714359011307 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 714359011308 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 714359011309 active site clefts [active] 714359011310 zinc binding site [ion binding]; other site 714359011311 dimer interface [polypeptide binding]; other site 714359011312 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 714359011313 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 714359011314 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 714359011315 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 714359011316 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 714359011317 putative active site [active] 714359011318 Uncharacterized conserved protein [Function unknown]; Region: COG1284 714359011319 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 714359011320 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 714359011321 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 714359011322 Predicted membrane protein [Function unknown]; Region: COG3766 714359011323 PspA/IM30 family; Region: PspA_IM30; pfam04012 714359011324 hypothetical protein; Provisional; Region: PRK06760; cl11698 714359011325 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 714359011326 Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this...; Region: FeoB; cd01879 714359011327 G1 box; other site 714359011328 GTP/Mg2+ binding site [chemical binding]; other site 714359011329 Switch I region; other site 714359011330 G2 box; other site 714359011331 G3 box; other site 714359011332 Switch II region; other site 714359011333 G4 box; other site 714359011334 G5 box; other site 714359011335 Nucleoside recognition; Region: Gate; cl00486 714359011336 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 714359011337 Nucleoside recognition; Region: Gate; cl00486 714359011338 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 714359011339 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359011340 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359011341 dimerization interface [polypeptide binding]; other site 714359011342 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359011343 dimer interface [polypeptide binding]; other site 714359011344 phosphorylation site [posttranslational modification] 714359011345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359011346 ATP binding site [chemical binding]; other site 714359011347 Mg2+ binding site [ion binding]; other site 714359011348 G-X-G motif; other site 714359011349 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359011350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359011351 active site 714359011352 phosphorylation site [posttranslational modification] 714359011353 intermolecular recognition site; other site 714359011354 dimerization interface [polypeptide binding]; other site 714359011355 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359011356 DNA binding site [nucleotide binding] 714359011357 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 714359011358 active site 714359011359 catalytic site [active] 714359011360 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 714359011361 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 714359011362 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 714359011363 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 714359011364 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 714359011365 FtsX-like permease family; Region: FtsX; pfam02687 714359011366 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 714359011367 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 714359011368 Walker A/P-loop; other site 714359011369 ATP binding site [chemical binding]; other site 714359011370 Q-loop/lid; other site 714359011371 ABC transporter signature motif; other site 714359011372 Walker B; other site 714359011373 D-loop; other site 714359011374 H-loop/switch region; other site 714359011375 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 714359011376 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 714359011377 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359011378 S-adenosylmethionine binding site [chemical binding]; other site 714359011379 FtsX-like permease family; Region: FtsX; pfam02687 714359011380 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 714359011381 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 714359011382 Walker A/P-loop; other site 714359011383 ATP binding site [chemical binding]; other site 714359011384 Q-loop/lid; other site 714359011385 ABC transporter signature motif; other site 714359011386 Walker B; other site 714359011387 D-loop; other site 714359011388 H-loop/switch region; other site 714359011389 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 714359011390 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714359011391 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 714359011392 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 714359011393 DNA binding residues [nucleotide binding] 714359011394 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 714359011395 DNA binding residues [nucleotide binding] 714359011396 pyrimidine utilization protein D; Region: RutD; TIGR03611 714359011397 Protein of unknown function (DUF1648); Region: DUF1648; cl01712 714359011398 Protein of unknown function (DUF1648); Region: DUF1648; cl01712 714359011399 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359011400 dimerization interface [polypeptide binding]; other site 714359011401 putative DNA binding site [nucleotide binding]; other site 714359011402 putative Zn2+ binding site [ion binding]; other site 714359011403 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359011404 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359011405 active site 714359011406 phosphorylation site [posttranslational modification] 714359011407 intermolecular recognition site; other site 714359011408 dimerization interface [polypeptide binding]; other site 714359011409 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359011410 DNA binding site [nucleotide binding] 714359011411 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359011412 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 714359011413 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359011414 ATP binding site [chemical binding]; other site 714359011415 Mg2+ binding site [ion binding]; other site 714359011416 G-X-G motif; other site 714359011417 FtsX-like permease family; Region: FtsX; pfam02687 714359011418 FtsX-like permease family; Region: FtsX; pfam02687 714359011419 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 714359011420 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 714359011421 Walker A/P-loop; other site 714359011422 ATP binding site [chemical binding]; other site 714359011423 Q-loop/lid; other site 714359011424 ABC transporter signature motif; other site 714359011425 Walker B; other site 714359011426 D-loop; other site 714359011427 H-loop/switch region; other site 714359011428 GntP family permease; Region: GntP_permease; cl15264 714359011429 gluconate transporter; Region: gntP; TIGR00791 714359011430 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 714359011431 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 714359011432 DNA-binding site [nucleotide binding]; DNA binding site 714359011433 UTRA domain; Region: UTRA; cl01230 714359011434 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 714359011435 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 714359011436 substrate binding site [chemical binding]; other site 714359011437 ATP binding site [chemical binding]; other site 714359011438 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 714359011439 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 714359011440 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 714359011441 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 714359011442 active site 714359011443 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 714359011444 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 714359011445 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 714359011446 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359011447 dimer interface [polypeptide binding]; other site 714359011448 phosphorylation site [posttranslational modification] 714359011449 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359011450 ATP binding site [chemical binding]; other site 714359011451 Mg2+ binding site [ion binding]; other site 714359011452 G-X-G motif; other site 714359011453 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359011454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359011455 active site 714359011456 phosphorylation site [posttranslational modification] 714359011457 intermolecular recognition site; other site 714359011458 dimerization interface [polypeptide binding]; other site 714359011459 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359011460 DNA binding site [nucleotide binding] 714359011461 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 714359011462 o-succinylbenzoic acid (OSB) synthetase; Region: menC_lowGC/arch; TIGR01928 714359011463 active site 714359011464 octamer interface [polypeptide binding]; other site 714359011465 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359011466 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 714359011467 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 714359011468 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 714359011469 substrate binding site [chemical binding]; other site 714359011470 oxyanion hole (OAH) forming residues; other site 714359011471 trimer interface [polypeptide binding]; other site 714359011472 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 714359011473 homoserine O-acetyltransferase; Provisional; Region: metX; cl15472 714359011474 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 714359011475 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 714359011476 dimer interface [polypeptide binding]; other site 714359011477 tetramer interface [polypeptide binding]; other site 714359011478 PYR/PP interface [polypeptide binding]; other site 714359011479 TPP binding site [chemical binding]; other site 714359011480 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 714359011481 TPP-binding site; other site 714359011482 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 714359011483 chorismate binding enzyme; Region: Chorismate_bind; cl10555 714359011484 UbiA prenyltransferase family; Region: UbiA; cl00337 714359011485 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 714359011486 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 714359011487 DNA-binding site [nucleotide binding]; DNA binding site 714359011488 RNA-binding motif; other site 714359011489 Protein of unknown function DUF124; Region: DUF124; cl00884 714359011490 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation,' the process of...; Region: Lipase_3; cd00519 714359011491 active site flap/lid [active] 714359011492 nucleophilic elbow; other site 714359011493 catalytic triad [active] 714359011494 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 714359011495 homodimer interface [polypeptide binding]; other site 714359011496 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 714359011497 active site pocket [active] 714359011498 glycogen synthase; Provisional; Region: glgA; PRK00654 714359011499 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 714359011500 ADP-binding pocket [chemical binding]; other site 714359011501 homodimer interface [polypeptide binding]; other site 714359011502 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 714359011503 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 714359011504 ligand binding site; other site 714359011505 oligomer interface; other site 714359011506 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 714359011507 dimer interface [polypeptide binding]; other site 714359011508 N-terminal domain interface [polypeptide binding]; other site 714359011509 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 714359011510 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 714359011511 ligand binding site; other site 714359011512 oligomer interface; other site 714359011513 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 714359011514 dimer interface [polypeptide binding]; other site 714359011515 N-terminal domain interface [polypeptide binding]; other site 714359011516 sulfate 1 binding site; other site 714359011517 glycogen branching enzyme; Provisional; Region: PRK05402 714359011518 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 714359011519 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 714359011520 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 714359011521 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 714359011522 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 714359011523 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 714359011524 putative active site [active] 714359011525 catalytic triad [active] 714359011526 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 714359011527 PA/protease domain interface [polypeptide binding]; other site 714359011528 putative integrin binding motif; other site 714359011529 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 714359011530 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 714359011531 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 714359011532 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 714359011533 tetramer (dimer of dimers) interface [polypeptide binding]; other site 714359011534 NAD binding site [chemical binding]; other site 714359011535 dimer interface [polypeptide binding]; other site 714359011536 substrate binding site [chemical binding]; other site 714359011537 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 714359011538 MgtC family; Region: MgtC; cl12207 714359011539 Ion channel; Region: Ion_trans_2; cl11596 714359011540 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 714359011541 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359011542 YugN-like family; Region: YugN; pfam08868 714359011543 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 714359011544 dimer interface [polypeptide binding]; other site 714359011545 active site 714359011546 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 714359011547 dimer interface [polypeptide binding]; other site 714359011548 active site 714359011549 Domain of unknown function (DUF378); Region: DUF378; cl00943 714359011550 general stress protein 13; Validated; Region: PRK08059 714359011551 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 714359011552 RNA binding site [nucleotide binding]; other site 714359011553 hypothetical protein; Validated; Region: PRK07682 714359011554 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714359011555 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359011556 homodimer interface [polypeptide binding]; other site 714359011557 catalytic residue [active] 714359011558 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359011559 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359011560 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 714359011561 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359011562 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 714359011563 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359011564 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 714359011565 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 714359011566 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 714359011567 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 714359011568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359011569 homodimer interface [polypeptide binding]; other site 714359011570 catalytic residue [active] 714359011571 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 714359011572 E-class dimer interface [polypeptide binding]; other site 714359011573 P-class dimer interface [polypeptide binding]; other site 714359011574 active site 714359011575 Cu2+ binding site [ion binding]; other site 714359011576 Zn2+ binding site [ion binding]; other site 714359011577 Kinase associated protein B; Region: KapB; pfam08810 714359011578 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 714359011579 active site 714359011580 substrate binding site [chemical binding]; other site 714359011581 catalytic site [active] 714359011582 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 714359011583 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 714359011584 transmembrane helices; other site 714359011585 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 714359011586 active site 714359011587 glycyl-tRNA synthetase; Provisional; Region: PRK04173 714359011588 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 714359011589 motif 1; other site 714359011590 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 714359011591 active site 714359011592 motif 2; other site 714359011593 motif 3; other site 714359011594 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 714359011595 anticodon binding site; other site 714359011596 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 714359011597 CoenzymeA binding site [chemical binding]; other site 714359011598 subunit interaction site [polypeptide binding]; other site 714359011599 PHB binding site; other site 714359011600 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 714359011601 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 714359011602 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 714359011603 active site 714359011604 tetramer interface; other site 714359011605 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 714359011606 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 714359011607 active site 714359011608 substrate binding site [chemical binding]; other site 714359011609 metal binding site [ion binding]; metal-binding site 714359011610 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 714359011611 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 714359011612 multifunctional aminopeptidase A; Provisional; Region: PRK00913 714359011613 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 714359011614 interface (dimer of trimers) [polypeptide binding]; other site 714359011615 Substrate-binding/catalytic site; other site 714359011616 Zn-binding sites [ion binding]; other site 714359011617 3D domain; Region: 3D; cl01439 714359011618 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 714359011619 nudix motif; other site 714359011620 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 714359011621 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359011622 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 714359011623 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359011624 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359011625 Gram positive anchor; Region: Gram_pos_anchor; cl15427 714359011626 Domain of unknown function DUF11; Region: DUF11; cl15273 714359011627 Domain of unknown function DUF11; Region: DUF11; cl15273 714359011628 Domain of unknown function DUF11; Region: DUF11; cl15273 714359011629 Domain of unknown function DUF11; Region: DUF11; cl15273 714359011630 Domain of unknown function DUF11; Region: DUF11; cl15273 714359011631 Domain of unknown function DUF11; Region: DUF11; cl15273 714359011632 Domain of unknown function DUF11; Region: DUF11; cl15273 714359011633 Domain of unknown function DUF11; Region: DUF11; cl15273 714359011634 Domain of unknown function DUF11; Region: DUF11; cl15273 714359011635 Domain of unknown function DUF11; Region: DUF11; cl15273 714359011636 Domain of unknown function DUF11; Region: DUF11; cl15273 714359011637 Domain of unknown function DUF11; Region: DUF11; cl15273 714359011638 Domain of unknown function DUF11; Region: DUF11; cl15273 714359011639 Domain of unknown function DUF11; Region: DUF11; cl15273 714359011640 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 714359011641 H+ Antiporter protein; Region: 2A0121; TIGR00900 714359011642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359011643 putative substrate translocation pore; other site 714359011644 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 714359011645 Protein of unknown function (DUF523); Region: DUF523; cl00733 714359011646 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 714359011647 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 714359011648 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 714359011649 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 714359011650 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 714359011651 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 714359011652 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 714359011653 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359011654 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 714359011655 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 714359011656 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359011657 Walker A/P-loop; other site 714359011658 ATP binding site [chemical binding]; other site 714359011659 Q-loop/lid; other site 714359011660 ABC transporter signature motif; other site 714359011661 Walker B; other site 714359011662 D-loop; other site 714359011663 H-loop/switch region; other site 714359011664 Uncharacterised protein family (UPF0014); Region: UPF0014; cl00424 714359011665 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 714359011666 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 714359011667 PhnA protein; Region: PhnA; pfam03831 714359011668 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 714359011669 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 714359011670 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 714359011671 active site 714359011672 NTP binding site [chemical binding]; other site 714359011673 metal binding triad [ion binding]; metal-binding site 714359011674 Protein of unknown function (DUF1462); Region: DUF1462; cl11552 714359011675 NifU-like domain; Region: NifU; cl00484 714359011676 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 714359011677 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 714359011678 tetramer interfaces [polypeptide binding]; other site 714359011679 binuclear metal-binding site [ion binding]; other site 714359011680 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 714359011681 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359011682 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 714359011683 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 714359011684 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359011685 active site 714359011686 motif I; other site 714359011687 motif II; other site 714359011688 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359011689 Predicted transcriptional regulator [Transcription]; Region: COG2345 714359011690 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359011691 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 714359011692 Protein of unknown function DUF86; Region: DUF86; cl01031 714359011693 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 714359011694 putative active site [active] 714359011695 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 714359011696 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 714359011697 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 714359011698 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 714359011699 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 714359011700 DNA binding residues [nucleotide binding] 714359011701 dimer interface [polypeptide binding]; other site 714359011702 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 714359011703 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 714359011704 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 714359011705 catalytic core [active] 714359011706 lipoyl synthase; Provisional; Region: PRK05481 714359011707 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359011708 FeS/SAM binding site; other site 714359011709 Peptidase family M23; Region: Peptidase_M23; pfam01551 714359011710 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 714359011711 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 714359011712 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 714359011713 active site 714359011714 metal binding site [ion binding]; metal-binding site 714359011715 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 714359011716 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 714359011717 FeS assembly protein SufB; Region: sufB; TIGR01980 714359011718 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 714359011719 trimerization site [polypeptide binding]; other site 714359011720 active site 714359011721 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 714359011722 Aminotransferase class-V; Region: Aminotran_5; pfam00266 714359011723 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 714359011724 catalytic residue [active] 714359011725 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 714359011726 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 714359011727 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 714359011728 FeS assembly ATPase SufC; Region: sufC; TIGR01978 714359011729 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 714359011730 Walker A/P-loop; other site 714359011731 ATP binding site [chemical binding]; other site 714359011732 Q-loop/lid; other site 714359011733 ABC transporter signature motif; other site 714359011734 Walker B; other site 714359011735 D-loop; other site 714359011736 H-loop/switch region; other site 714359011737 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 714359011738 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 714359011739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 714359011740 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 714359011741 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 714359011742 Walker A/P-loop; other site 714359011743 ATP binding site [chemical binding]; other site 714359011744 Q-loop/lid; other site 714359011745 ABC transporter signature motif; other site 714359011746 Walker B; other site 714359011747 D-loop; other site 714359011748 H-loop/switch region; other site 714359011749 NIL domain; Region: NIL; cl09633 714359011750 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 714359011751 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 714359011752 putative active site [active] 714359011753 putative metal binding site [ion binding]; other site 714359011754 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 714359011755 lipoyl attachment site [posttranslational modification]; other site 714359011756 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 714359011757 ArsC family; Region: ArsC; pfam03960 714359011758 putative ArsC-like catalytic residues; other site 714359011759 putative TRX-like catalytic residues [active] 714359011760 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 714359011761 active site 714359011762 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 714359011763 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 714359011764 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 714359011765 tetramer (dimer of dimers) interface [polypeptide binding]; other site 714359011766 NAD binding site [chemical binding]; other site 714359011767 dimer interface [polypeptide binding]; other site 714359011768 substrate binding site [chemical binding]; other site 714359011769 Coat F domain; Region: Coat_F; cl02368 714359011770 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 714359011771 tetracycline repressor protein TetR; Provisional; Region: PRK13756 714359011772 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 714359011773 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 714359011774 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 714359011775 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 714359011776 active site 714359011777 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 714359011778 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 714359011779 dimer interface [polypeptide binding]; other site 714359011780 active site 714359011781 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 714359011782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 714359011783 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 714359011784 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 714359011785 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 714359011786 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 714359011787 substrate binding site [chemical binding]; other site 714359011788 oxyanion hole (OAH) forming residues; other site 714359011789 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 714359011790 Proline dehydrogenase; Region: Pro_dh; cl03282 714359011791 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 714359011792 Domain of unknown function DUF77; Region: DUF77; cl00307 714359011793 Cache domain; Region: Cache_1; pfam02743 714359011794 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 714359011795 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359011796 dimerization interface [polypeptide binding]; other site 714359011797 Microvirus H protein (pilot protein); Region: Microvir_H; cl11620 714359011798 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 714359011799 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These transmembrane...; Region: TarH; cl00144 714359011800 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359011801 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 714359011802 C-terminal domain interface [polypeptide binding]; other site 714359011803 sugar binding site [chemical binding]; other site 714359011804 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 714359011805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359011806 putative substrate translocation pore; other site 714359011807 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 714359011808 Amino acid permease; Region: AA_permease; cl00524 714359011809 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 714359011810 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 714359011811 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 714359011812 Uncharacterized conserved protein [Function unknown]; Region: COG1284 714359011813 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 714359011814 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 714359011815 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 714359011816 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359011817 hypothetical protein; Provisional; Region: PRK06758 714359011818 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 714359011819 active site 714359011820 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359011821 non-specific DNA binding site [nucleotide binding]; other site 714359011822 salt bridge; other site 714359011823 sequence-specific DNA binding site [nucleotide binding]; other site 714359011824 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 714359011825 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 714359011826 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359011827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359011828 active site 714359011829 phosphorylation site [posttranslational modification] 714359011830 intermolecular recognition site; other site 714359011831 dimerization interface [polypeptide binding]; other site 714359011832 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359011833 DNA binding site [nucleotide binding] 714359011834 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359011835 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359011836 dimer interface [polypeptide binding]; other site 714359011837 phosphorylation site [posttranslational modification] 714359011838 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359011839 ATP binding site [chemical binding]; other site 714359011840 Mg2+ binding site [ion binding]; other site 714359011841 G-X-G motif; other site 714359011842 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 714359011843 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 714359011844 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 714359011845 active site 714359011846 HIGH motif; other site 714359011847 KMSKS motif; other site 714359011848 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 714359011849 tRNA binding surface [nucleotide binding]; other site 714359011850 anticodon binding site; other site 714359011851 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359011852 S-adenosylmethionine binding site [chemical binding]; other site 714359011853 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 714359011854 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359011855 dimerization interface [polypeptide binding]; other site 714359011856 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 714359011857 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These transmembrane...; Region: TarH; cl00144 714359011858 CHASE3 domain; Region: CHASE3; cl05000 714359011859 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359011860 dimerization interface [polypeptide binding]; other site 714359011861 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These transmembrane...; Region: TarH; cl00144 714359011862 Domain of unknown function DUF59; Region: DUF59; cl00941 714359011863 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 714359011864 Peptidase propeptide and YPEB domain; Region: PepSY; cl15480 714359011865 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 714359011866 active site 714359011867 Zn binding site [ion binding]; other site 714359011868 Pirin-related protein [General function prediction only]; Region: COG1741 714359011869 Cupin domain; Region: Cupin_2; cl09118 714359011870 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359011871 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 714359011872 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 714359011873 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 714359011874 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 714359011875 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 714359011876 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 714359011877 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 714359011878 Ferritin-like domain; Region: Ferritin; pfam00210 714359011879 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 714359011880 dimerization interface [polypeptide binding]; other site 714359011881 DPS ferroxidase diiron center [ion binding]; other site 714359011882 ion pore; other site 714359011883 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 714359011884 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 714359011885 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 714359011886 Ferritin-like domain; Region: Ferritin; pfam00210 714359011887 ferroxidase diiron center [ion binding]; other site 714359011888 Predicted membrane protein [Function unknown]; Region: COG2311 714359011889 Protein of unknown function (DUF418); Region: DUF418; cl12135 714359011890 Protein of unknown function (DUF418); Region: DUF418; cl12135 714359011891 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 714359011892 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 714359011893 Nucleoside recognition; Region: Gate; cl00486 714359011894 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 714359011895 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 714359011896 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 714359011897 Nucleoside recognition; Region: Gate; cl00486 714359011898 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 714359011899 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 714359011900 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 714359011901 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 714359011902 NAD binding site [chemical binding]; other site 714359011903 substrate binding site [chemical binding]; other site 714359011904 putative active site [active] 714359011905 Viral enhancin protein; Region: Enhancin; pfam03272 714359011906 Viral enhancin protein; Region: Enhancin; pfam03272 714359011907 Viral enhancin protein; Region: Enhancin; pfam03272 714359011908 TQXA domain; Region: TQXA_dom; TIGR03934 714359011909 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 714359011910 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 714359011911 active site 714359011912 catalytic tetrad [active] 714359011913 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 714359011914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359011915 putative substrate translocation pore; other site 714359011916 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359011917 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 714359011918 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 714359011919 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359011920 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 714359011921 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 714359011922 active site 714359011923 HIGH motif; other site 714359011924 dimer interface [polypeptide binding]; other site 714359011925 KMSKS motif; other site 714359011926 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 714359011927 RNA binding surface [nucleotide binding]; other site 714359011928 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK12436 714359011929 FAD binding domain; Region: FAD_binding_4; pfam01565 714359011930 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 714359011931 SET domain; Region: SET; cl02566 714359011932 Aluminium activated malate transporter; Region: ALMT; pfam11744 714359011933 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 714359011934 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These transmembrane...; Region: TarH; cl00144 714359011935 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 714359011936 putative phosphate binding site [ion binding]; other site 714359011937 CrcB-like protein; Region: CRCB; cl09114 714359011938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359011939 H+ Antiporter protein; Region: 2A0121; TIGR00900 714359011940 putative substrate translocation pore; other site 714359011941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359011942 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 714359011943 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 714359011944 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359011945 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 714359011946 ABC transporter; Region: ABC_tran_2; pfam12848 714359011947 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 714359011948 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 714359011949 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359011950 Phosphate-starvation-inducible E; Region: PsiE; cl01264 714359011951 Nuclease-related domain; Region: NERD; pfam08378 714359011952 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 714359011953 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 714359011954 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 714359011955 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 714359011956 Walker A/P-loop; other site 714359011957 ATP binding site [chemical binding]; other site 714359011958 Q-loop/lid; other site 714359011959 ABC transporter signature motif; other site 714359011960 Walker B; other site 714359011961 D-loop; other site 714359011962 H-loop/switch region; other site 714359011963 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714359011964 ABC-ATPase subunit interface; other site 714359011965 dimer interface [polypeptide binding]; other site 714359011966 putative PBP binding regions; other site 714359011967 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714359011968 ABC-ATPase subunit interface; other site 714359011969 dimer interface [polypeptide binding]; other site 714359011970 putative PBP binding regions; other site 714359011971 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 714359011972 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 714359011973 putative ligand binding residues [chemical binding]; other site 714359011974 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359011975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359011976 active site 714359011977 phosphorylation site [posttranslational modification] 714359011978 intermolecular recognition site; other site 714359011979 dimerization interface [polypeptide binding]; other site 714359011980 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359011981 DNA binding site [nucleotide binding] 714359011982 Z1 domain; Region: Z1; pfam10593 714359011983 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 714359011984 SmpB-tmRNA interface; other site 714359011985 ribonuclease R; Region: RNase_R; TIGR02063 714359011986 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 714359011987 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 714359011988 RNB domain; Region: RNB; pfam00773 714359011989 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 714359011990 RNA binding site [nucleotide binding]; other site 714359011991 Esterase/lipase [General function prediction only]; Region: COG1647 714359011992 Preprotein translocase SecG subunit; Region: SecG; cl09123 714359011993 LrgB-like family; Region: LrgB; cl00596 714359011994 LrgA family; Region: LrgA; cl00608 714359011995 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 714359011996 active site 714359011997 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 714359011998 Phage terminase, small subunit; Region: Terminase_4; cl01525 714359011999 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 714359012000 Phage Terminase; Region: Terminase_1; pfam03354 714359012001 Phage-related protein [Function unknown]; Region: COG4695; cl01923 714359012002 Phage portal protein; Region: Phage_portal; pfam04860 714359012003 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 714359012004 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 714359012005 Phage capsid family; Region: Phage_capsid; pfam05065 714359012006 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 714359012007 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 714359012008 DNA binding site [nucleotide binding] 714359012009 Int/Topo IB signature motif; other site 714359012010 active site 714359012011 enolase; Provisional; Region: eno; PRK00077 714359012012 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 714359012013 dimer interface [polypeptide binding]; other site 714359012014 metal binding site [ion binding]; metal-binding site 714359012015 substrate binding pocket [chemical binding]; other site 714359012016 Sulfatase; Region: Sulfatase; cl10460 714359012017 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 714359012018 substrate binding site [chemical binding]; other site 714359012019 dimer interface [polypeptide binding]; other site 714359012020 catalytic triad [active] 714359012021 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 714359012022 substrate binding site [chemical binding]; other site 714359012023 hinge regions; other site 714359012024 ADP binding site [chemical binding]; other site 714359012025 catalytic site [active] 714359012026 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 714359012027 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 714359012028 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 714359012029 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 714359012030 Predicted transcriptional regulator [Transcription]; Region: COG3388 714359012031 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 714359012032 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 714359012033 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 714359012034 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 714359012035 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 714359012036 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 714359012037 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 714359012038 SpoVA protein; Region: SpoVA; cl04298 714359012039 stage V sporulation protein AD; Provisional; Region: PRK12404 714359012040 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 714359012041 SpoVA protein; Region: SpoVA; cl04298 714359012042 Protein of unknown function (DUF421); Region: DUF421; cl00990 714359012043 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 714359012044 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 714359012045 oligomer interface [polypeptide binding]; other site 714359012046 active site residues [active] 714359012047 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 714359012048 dimerization domain swap beta strand [polypeptide binding]; other site 714359012049 regulatory protein interface [polypeptide binding]; other site 714359012050 active site 714359012051 regulatory phosphorylation site [posttranslational modification]; other site 714359012052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 714359012053 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 714359012054 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 714359012055 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 714359012056 phosphate binding site [ion binding]; other site 714359012057 putative substrate binding pocket [chemical binding]; other site 714359012058 dimer interface [polypeptide binding]; other site 714359012059 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359012060 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 714359012061 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 714359012062 nudix motif; other site 714359012063 Domain of unknown function (DUF368); Region: DUF368; cl00893 714359012064 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 714359012065 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359012066 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359012067 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359012068 TPR motif; other site 714359012069 binding surface 714359012070 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 714359012071 binding surface 714359012072 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 714359012073 TPR motif; other site 714359012074 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 714359012075 trimer interface [polypeptide binding]; other site 714359012076 active site 714359012077 substrate binding site [chemical binding]; other site 714359012078 CoA binding site [chemical binding]; other site 714359012079 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 714359012080 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359012081 active site 714359012082 motif I; other site 714359012083 motif II; other site 714359012084 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 714359012085 HPr kinase/phosphorylase; Provisional; Region: PRK05428 714359012086 DRTGG domain; Region: DRTGG; cl12147 714359012087 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 714359012088 Hpr binding site; other site 714359012089 active site 714359012090 homohexamer subunit interaction site [polypeptide binding]; other site 714359012091 Membrane protein of unknown function; Region: DUF360; cl00850 714359012092 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 714359012093 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 714359012094 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 714359012095 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 714359012096 excinuclease ABC subunit B; Provisional; Region: PRK05298 714359012097 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714359012098 ATP binding site [chemical binding]; other site 714359012099 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714359012100 nucleotide binding region [chemical binding]; other site 714359012101 ATP-binding site [chemical binding]; other site 714359012102 Ultra-violet resistance protein B; Region: UvrB; pfam12344 714359012103 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 714359012104 DNA binding residues [nucleotide binding] 714359012105 dimer interface [polypeptide binding]; other site 714359012106 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 714359012107 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 714359012108 Transcriptional regulator [Transcription]; Region: LysR; COG0583 714359012109 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359012110 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 714359012111 putative dimerization interface [polypeptide binding]; other site 714359012112 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 714359012113 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 714359012114 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 714359012115 ABC transporter; Region: ABC_tran_2; pfam12848 714359012116 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 714359012117 Domain of unknown function (DUF74); Region: DUF74; cl00426 714359012118 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 714359012119 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 714359012120 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 714359012121 Walker A/P-loop; other site 714359012122 ATP binding site [chemical binding]; other site 714359012123 Q-loop/lid; other site 714359012124 ABC transporter signature motif; other site 714359012125 Walker B; other site 714359012126 D-loop; other site 714359012127 H-loop/switch region; other site 714359012128 transcriptional regulator MirA; Provisional; Region: PRK15043 714359012129 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 714359012130 protein binding site [polypeptide binding]; other site 714359012131 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 714359012132 C-terminal peptidase (prc); Region: prc; TIGR00225 714359012133 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 714359012134 protein binding site [polypeptide binding]; other site 714359012135 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 714359012136 Catalytic dyad [active] 714359012137 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 714359012138 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 714359012139 FtsX-like permease family; Region: FtsX; pfam02687 714359012140 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359012141 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 714359012142 Walker A/P-loop; other site 714359012143 ATP binding site [chemical binding]; other site 714359012144 Q-loop/lid; other site 714359012145 ABC transporter signature motif; other site 714359012146 Walker B; other site 714359012147 D-loop; other site 714359012148 H-loop/switch region; other site 714359012149 Cytochrome c; Region: Cytochrom_C; cl11414 714359012150 peptide chain release factor 2; Provisional; Region: PRK06746 714359012151 RF-1 domain; Region: RF-1; cl02875 714359012152 RF-1 domain; Region: RF-1; cl02875 714359012153 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 714359012154 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359012155 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 714359012156 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714359012157 nucleotide binding region [chemical binding]; other site 714359012158 ATP-binding site [chemical binding]; other site 714359012159 SEC-C motif; Region: SEC-C; pfam02810 714359012160 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 714359012161 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359012162 Walker A/P-loop; other site 714359012163 ATP binding site [chemical binding]; other site 714359012164 Q-loop/lid; other site 714359012165 ABC transporter signature motif; other site 714359012166 Walker B; other site 714359012167 D-loop; other site 714359012168 H-loop/switch region; other site 714359012169 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 714359012170 30S subunit binding site; other site 714359012171 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 714359012172 DNA-binding site [nucleotide binding]; DNA binding site 714359012173 RNA-binding motif; other site 714359012174 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 714359012175 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 714359012176 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 714359012177 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714359012178 ATP binding site [chemical binding]; other site 714359012179 putative Mg++ binding site [ion binding]; other site 714359012180 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714359012181 nucleotide binding region [chemical binding]; other site 714359012182 ATP-binding site [chemical binding]; other site 714359012183 Cortexillin I, coiled coil; Region: Cortex-I_coil; pfam09304 714359012184 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 714359012185 NlpC/P60 family; Region: NLPC_P60; cl11438 714359012186 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359012187 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 714359012188 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 714359012189 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 714359012190 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 714359012191 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 714359012192 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 714359012193 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 714359012194 active site 714359012195 homodimer interface [polypeptide binding]; other site 714359012196 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 714359012197 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359012198 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 714359012199 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359012200 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 714359012201 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 714359012202 Mg++ binding site [ion binding]; other site 714359012203 putative catalytic motif [active] 714359012204 substrate binding site [chemical binding]; other site 714359012205 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 714359012206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359012207 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 714359012208 Walker A motif; other site 714359012209 ATP binding site [chemical binding]; other site 714359012210 Walker B motif; other site 714359012211 arginine finger; other site 714359012212 Transcriptional antiterminator [Transcription]; Region: COG3933 714359012213 PRD domain; Region: PRD; cl15445 714359012214 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 714359012215 active pocket/dimerization site; other site 714359012216 active site 714359012217 phosphorylation site [posttranslational modification] 714359012218 PRD domain; Region: PRD; cl15445 714359012219 CHRD domain; Region: CHRD; cl06473 714359012220 Chromate transporter; Region: Chromate_transp; pfam02417 714359012221 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 714359012222 Chromate transporter; Region: Chromate_transp; pfam02417 714359012223 YdjC-like protein; Region: YdjC; cl01344 714359012224 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 714359012225 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 714359012226 NAD binding site [chemical binding]; other site 714359012227 sugar binding site [chemical binding]; other site 714359012228 divalent metal binding site [ion binding]; other site 714359012229 tetramer (dimer of dimers) interface [polypeptide binding]; other site 714359012230 dimer interface [polypeptide binding]; other site 714359012231 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 714359012232 active site 714359012233 methionine cluster; other site 714359012234 phosphorylation site [posttranslational modification] 714359012235 metal binding site [ion binding]; metal-binding site 714359012236 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 714359012237 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 714359012238 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 714359012239 active site 714359012240 P-loop; other site 714359012241 phosphorylation site [posttranslational modification] 714359012242 spermidine synthase; Provisional; Region: PRK03612 714359012243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359012244 S-adenosylmethionine binding site [chemical binding]; other site 714359012245 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 714359012246 methionine cluster; other site 714359012247 active site 714359012248 phosphorylation site [posttranslational modification] 714359012249 metal binding site [ion binding]; metal-binding site 714359012250 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 714359012251 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 714359012252 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 714359012253 active site 714359012254 P-loop; other site 714359012255 phosphorylation site [posttranslational modification] 714359012256 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 714359012257 Acyltransferase family; Region: Acyl_transf_3; pfam01757 714359012258 OpgC protein; Region: OpgC_C; cl00792 714359012259 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 714359012260 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 714359012261 active site 714359012262 catalytic site [active] 714359012263 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359012264 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 714359012265 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359012266 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359012267 Gram positive anchor; Region: Gram_pos_anchor; cl15427 714359012268 Domain of unknown function DUF11; Region: DUF11; cl15273 714359012269 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 714359012270 Domain of unknown function DUF11; Region: DUF11; cl15273 714359012271 Domain of unknown function DUF11; Region: DUF11; cl15273 714359012272 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359012273 Predicted membrane protein [Function unknown]; Region: COG1511 714359012274 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 714359012275 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 714359012276 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 714359012277 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 714359012278 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359012279 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 714359012280 putative dimerization interface [polypeptide binding]; other site 714359012281 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 714359012282 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 714359012283 arsenical pump membrane protein; Provisional; Region: PRK15445 714359012284 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 714359012285 transmembrane helices; other site 714359012286 ThiC family; Region: ThiC; cl08031 714359012287 L-lactate permease; Region: Lactate_perm; cl00701 714359012288 glycolate transporter; Provisional; Region: PRK09695 714359012289 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; cl01017 714359012290 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 714359012291 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 714359012292 Sulfatase; Region: Sulfatase; cl10460 714359012293 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 714359012294 homodimer interface [polypeptide binding]; other site 714359012295 substrate-cofactor binding pocket; other site 714359012296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359012297 Aminotransferase class IV; Region: Aminotran_4; pfam01063 714359012298 catalytic residue [active] 714359012299 Bacterial SH3 domain; Region: SH3_3; cl02551 714359012300 Bacterial SH3 domain; Region: SH3_3; cl02551 714359012301 Bacterial SH3 domain; Region: SH3_3; cl02551 714359012302 Bacterial SH3 domain; Region: SH3_3; cl02551 714359012303 Bacterial SH3 domain; Region: SH3_3; cl02551 714359012304 NlpC/P60 family; Region: NLPC_P60; cl11438 714359012305 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 714359012306 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 714359012307 Nucleoside recognition; Region: Gate; cl00486 714359012308 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 714359012309 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 714359012310 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 714359012311 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 714359012312 DXD motif; other site 714359012313 BCCT family transporter; Region: BCCT; cl00569 714359012314 Bacterial SH3 domain; Region: SH3_3; cl02551 714359012315 Bacterial SH3 domain; Region: SH3_3; cl02551 714359012316 3D domain; Region: 3D; cl01439 714359012317 Predicted membrane protein [Function unknown]; Region: COG4640 714359012318 Double zinc ribbon; Region: DZR; pfam12773 714359012319 Double zinc ribbon; Region: DZR; pfam12773 714359012320 SNF2 Helicase protein; Region: DUF3670; pfam12419 714359012321 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 714359012322 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 714359012323 ATP binding site [chemical binding]; other site 714359012324 putative Mg++ binding site [ion binding]; other site 714359012325 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714359012326 nucleotide binding region [chemical binding]; other site 714359012327 ATP-binding site [chemical binding]; other site 714359012328 VanZ like family; Region: VanZ; cl01971 714359012329 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 714359012330 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 714359012331 ComK protein; Region: ComK; cl11560 714359012332 RNA polymerase factor sigma-70; Validated; Region: PRK06759 714359012333 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359012334 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714359012335 DNA binding residues [nucleotide binding] 714359012336 Yip1 domain; Region: Yip1; cl12048 714359012337 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 714359012338 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 714359012339 FtsX-like permease family; Region: FtsX; pfam02687 714359012340 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 714359012341 Q-loop/lid; other site 714359012342 ABC transporter signature motif; other site 714359012343 Walker B; other site 714359012344 D-loop; other site 714359012345 H-loop/switch region; other site 714359012346 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 714359012347 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 714359012348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359012349 putative substrate translocation pore; other site 714359012350 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 714359012351 sensory histidine kinase CreC; Provisional; Region: PRK11100 714359012352 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359012353 dimerization interface [polypeptide binding]; other site 714359012354 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359012355 dimer interface [polypeptide binding]; other site 714359012356 phosphorylation site [posttranslational modification] 714359012357 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359012358 ATP binding site [chemical binding]; other site 714359012359 Mg2+ binding site [ion binding]; other site 714359012360 G-X-G motif; other site 714359012361 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359012362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359012363 active site 714359012364 phosphorylation site [posttranslational modification] 714359012365 intermolecular recognition site; other site 714359012366 dimerization interface [polypeptide binding]; other site 714359012367 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359012368 DNA binding site [nucleotide binding] 714359012369 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 714359012370 active site 714359012371 catalytic triad [active] 714359012372 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 714359012373 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 714359012374 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 714359012375 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 714359012376 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 714359012377 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 714359012378 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 714359012379 trimer interface [polypeptide binding]; other site 714359012380 active site 714359012381 substrate binding site [chemical binding]; other site 714359012382 CoA binding site [chemical binding]; other site 714359012383 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 714359012384 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 714359012385 NAD binding site [chemical binding]; other site 714359012386 substrate binding site [chemical binding]; other site 714359012387 homodimer interface [polypeptide binding]; other site 714359012388 active site 714359012389 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 714359012390 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 714359012391 NADP binding site [chemical binding]; other site 714359012392 active site 714359012393 putative substrate binding site [chemical binding]; other site 714359012394 Cupin domain; Region: Cupin_2; cl09118 714359012395 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 714359012396 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 714359012397 substrate binding site; other site 714359012398 tetramer interface; other site 714359012399 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 714359012400 MatE; Region: MatE; cl10513 714359012401 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 714359012402 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 714359012403 Probable Catalytic site; other site 714359012404 metal-binding site 714359012405 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 714359012406 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 714359012407 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359012408 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 714359012409 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359012410 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 714359012411 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 714359012412 active site 714359012413 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 714359012414 Probable Catalytic site; other site 714359012415 metal-binding site 714359012416 Bacterial sugar transferase; Region: Bac_transf; cl00939 714359012417 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 714359012418 active site 714359012419 tetramer interface; other site 714359012420 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 714359012421 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 714359012422 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359012423 Chain length determinant protein; Region: Wzz; cl01623 714359012424 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 714359012425 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359012426 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 714359012427 rod shape-determining protein Mbl; Provisional; Region: PRK13928 714359012428 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 714359012429 ATP binding site [chemical binding]; other site 714359012430 profilin binding site; other site 714359012431 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359012432 Peptidase family M23; Region: Peptidase_M23; pfam01551 714359012433 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 714359012434 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 714359012435 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359012436 Walker A/P-loop; other site 714359012437 ATP binding site [chemical binding]; other site 714359012438 Q-loop/lid; other site 714359012439 ABC transporter signature motif; other site 714359012440 Walker B; other site 714359012441 D-loop; other site 714359012442 H-loop/switch region; other site 714359012443 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 714359012444 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359012445 Walker A/P-loop; other site 714359012446 ATP binding site [chemical binding]; other site 714359012447 Q-loop/lid; other site 714359012448 ABC transporter signature motif; other site 714359012449 Walker B; other site 714359012450 D-loop; other site 714359012451 H-loop/switch region; other site 714359012452 LytTr DNA-binding domain; Region: LytTR; cl04498 714359012453 stage II sporulation protein D; Region: spore_II_D; TIGR02870 714359012454 Stage II sporulation protein; Region: SpoIID; pfam08486 714359012455 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 714359012456 hinge; other site 714359012457 active site 714359012458 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 714359012459 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 714359012460 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 714359012461 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 714359012462 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 714359012463 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 714359012464 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 714359012465 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 714359012466 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 714359012467 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 714359012468 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 714359012469 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 714359012470 4Fe-4S binding domain; Region: Fer4; cl02805 714359012471 4Fe-4S binding domain; Region: Fer4; cl02805 714359012472 NADH dehydrogenase; Region: NADHdh; cl00469 714359012473 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 714359012474 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539 714359012475 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 714359012476 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 714359012477 PAS domain S-box; Region: sensory_box; TIGR00229 714359012478 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 714359012479 putative active site [active] 714359012480 heme pocket [chemical binding]; other site 714359012481 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714359012482 metal binding site [ion binding]; metal-binding site 714359012483 active site 714359012484 I-site; other site 714359012485 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 714359012486 Protein of unknown function (DUF975); Region: DUF975; cl10504 714359012487 Protein of unknown function (DUF975); Region: DUF975; cl10504 714359012488 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 714359012489 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 714359012490 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 714359012491 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 714359012492 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 714359012493 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 714359012494 alpha subunit interaction interface [polypeptide binding]; other site 714359012495 Walker A motif; other site 714359012496 ATP binding site [chemical binding]; other site 714359012497 Walker B motif; other site 714359012498 inhibitor binding site; inhibition site 714359012499 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 714359012500 ATP synthase; Region: ATP-synt; cl00365 714359012501 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 714359012502 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 714359012503 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 714359012504 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 714359012505 beta subunit interaction interface [polypeptide binding]; other site 714359012506 Walker A motif; other site 714359012507 ATP binding site [chemical binding]; other site 714359012508 Walker B motif; other site 714359012509 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 714359012510 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl15360 714359012511 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 714359012512 Plant ATP synthase F0; Region: YMF19; cl07975 714359012513 ATP synthase subunit C; Region: ATP-synt_C; cl00466 714359012514 ATP synthase A chain; Region: ATP-synt_A; cl00413 714359012515 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 714359012516 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 714359012517 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 714359012518 dimer interface [polypeptide binding]; other site 714359012519 glycine-pyridoxal phosphate binding site [chemical binding]; other site 714359012520 active site 714359012521 folate binding site [chemical binding]; other site 714359012522 Protein of unknown function (DUF436); Region: DUF436; cl01860 714359012523 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 714359012524 Low molecular weight phosphatase family; Region: LMWPc; cd00115 714359012525 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 714359012526 active site 714359012527 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 714359012528 HPr interaction site; other site 714359012529 glycerol kinase (GK) interaction site [polypeptide binding]; other site 714359012530 active site 714359012531 phosphorylation site [posttranslational modification] 714359012532 DoxX; Region: DoxX; cl00976 714359012533 Flavin Reductases; Region: FlaRed; cl00801 714359012534 Domain of unknown function DUF; Region: DUF204; pfam02659 714359012535 Domain of unknown function DUF; Region: DUF204; pfam02659 714359012536 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 714359012537 SUA5 domain; Region: SUA5; pfam03481 714359012538 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359012539 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775 714359012540 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 714359012541 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359012542 S-adenosylmethionine binding site [chemical binding]; other site 714359012543 peptide chain release factor 1; Validated; Region: prfA; PRK00591 714359012544 RF-1 domain; Region: RF-1; cl02875 714359012545 RF-1 domain; Region: RF-1; cl02875 714359012546 Thymidine kinase; Region: TK; cl00631 714359012547 transcription termination factor Rho; Provisional; Region: rho; PRK09376 714359012548 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 714359012549 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 714359012550 RNA binding site [nucleotide binding]; other site 714359012551 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 714359012552 multimer interface [polypeptide binding]; other site 714359012553 Walker A motif; other site 714359012554 ATP binding site [chemical binding]; other site 714359012555 Walker B motif; other site 714359012556 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 714359012557 putative active site [active] 714359012558 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 714359012559 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 714359012560 hinge; other site 714359012561 active site 714359012562 hypothetical protein; Provisional; Region: PRK08185 714359012563 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 714359012564 intersubunit interface [polypeptide binding]; other site 714359012565 active site 714359012566 zinc binding site [ion binding]; other site 714359012567 Na+ binding site [ion binding]; other site 714359012568 Response regulator receiver domain; Region: Response_reg; pfam00072 714359012569 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359012570 active site 714359012571 phosphorylation site [posttranslational modification] 714359012572 intermolecular recognition site; other site 714359012573 dimerization interface [polypeptide binding]; other site 714359012574 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 714359012575 CTP synthetase; Validated; Region: pyrG; PRK05380 714359012576 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 714359012577 Catalytic site [active] 714359012578 active site 714359012579 UTP binding site [chemical binding]; other site 714359012580 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 714359012581 active site 714359012582 putative oxyanion hole; other site 714359012583 catalytic triad [active] 714359012584 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 714359012585 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359012586 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359012587 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 714359012588 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 714359012589 FAD binding site [chemical binding]; other site 714359012590 homotetramer interface [polypeptide binding]; other site 714359012591 substrate binding pocket [chemical binding]; other site 714359012592 catalytic base [active] 714359012593 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 714359012594 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 714359012595 FAD binding site [chemical binding]; other site 714359012596 homotetramer interface [polypeptide binding]; other site 714359012597 substrate binding pocket [chemical binding]; other site 714359012598 catalytic base [active] 714359012599 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 714359012600 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 714359012601 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 714359012602 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 714359012603 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 714359012604 dimer interface [polypeptide binding]; other site 714359012605 active site 714359012606 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 714359012607 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 714359012608 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 714359012609 Cysteine-rich domain; Region: CCG; pfam02754 714359012610 Cysteine-rich domain; Region: CCG; pfam02754 714359012611 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 714359012612 putative active site [active] 714359012613 catalytic site [active] 714359012614 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 714359012615 putative active site [active] 714359012616 catalytic site [active] 714359012617 UV-endonuclease UvdE; Region: UvdE; cl10036 714359012618 PAS domain S-box; Region: sensory_box; TIGR00229 714359012619 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714359012620 metal binding site [ion binding]; metal-binding site 714359012621 active site 714359012622 I-site; other site 714359012623 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 714359012624 Bacillus PapR protein; Region: Bacillus_PapR; pfam05968 714359012625 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359012626 non-specific DNA binding site [nucleotide binding]; other site 714359012627 salt bridge; other site 714359012628 sequence-specific DNA binding site [nucleotide binding]; other site 714359012629 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 714359012630 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 714359012631 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 714359012632 active site 714359012633 Zn binding site [ion binding]; other site 714359012634 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 714359012635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359012636 active site 714359012637 phosphorylation site [posttranslational modification] 714359012638 intermolecular recognition site; other site 714359012639 dimerization interface [polypeptide binding]; other site 714359012640 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714359012641 DNA binding residues [nucleotide binding] 714359012642 dimerization interface [polypeptide binding]; other site 714359012643 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 714359012644 Histidine kinase; Region: HisKA_3; pfam07730 714359012645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 714359012646 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 714359012647 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 714359012648 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 714359012649 Walker A/P-loop; other site 714359012650 ATP binding site [chemical binding]; other site 714359012651 Q-loop/lid; other site 714359012652 ABC transporter signature motif; other site 714359012653 Walker B; other site 714359012654 D-loop; other site 714359012655 H-loop/switch region; other site 714359012656 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 714359012657 active site 714359012658 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 714359012659 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 714359012660 Collagen binding domain; Region: Collagen_bind; pfam05737 714359012661 Collagen binding domain; Region: Collagen_bind; pfam05737 714359012662 Collagen binding domain; Region: Collagen_bind; pfam05737 714359012663 Collagen binding domain; Region: Collagen_bind; pfam05737 714359012664 Collagen binding domain; Region: Collagen_bind; pfam05737 714359012665 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359012666 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359012667 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359012668 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359012669 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359012670 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359012671 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359012672 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359012673 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359012674 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359012675 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359012676 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359012677 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359012678 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359012679 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359012680 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359012681 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359012682 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359012683 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359012684 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 714359012685 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 714359012686 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 714359012687 PA/protease or protease-like domain interface [polypeptide binding]; other site 714359012688 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 714359012689 metal binding site [ion binding]; metal-binding site 714359012690 RNA polymerase sigma factor; Provisional; Region: PRK12522 714359012691 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359012692 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 714359012693 DNA binding residues [nucleotide binding] 714359012694 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 714359012695 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 714359012696 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 714359012697 active site 714359012698 HIGH motif; other site 714359012699 KMSK motif region; other site 714359012700 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 714359012701 tRNA binding surface [nucleotide binding]; other site 714359012702 anticodon binding site; other site 714359012703 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 714359012704 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 714359012705 putative dimer interface [polypeptide binding]; other site 714359012706 catalytic triad [active] 714359012707 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 714359012708 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 714359012709 Arginase family; Region: Arginase; cl00306 714359012710 spermidine synthase; Provisional; Region: PRK00811 714359012711 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359012712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359012713 Major Facilitator Superfamily; Region: MFS_1; pfam07690 714359012714 putative substrate translocation pore; other site 714359012715 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 714359012716 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 714359012717 DNA binding residues [nucleotide binding] 714359012718 putative dimer interface [polypeptide binding]; other site 714359012719 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 714359012720 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 714359012721 active site 714359012722 catalytic site [active] 714359012723 metal binding site [ion binding]; metal-binding site 714359012724 dimer interface [polypeptide binding]; other site 714359012725 Transglycosylase; Region: Transgly; cl07896 714359012726 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 714359012727 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359012728 YwhD family; Region: YwhD; pfam08741 714359012729 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 714359012730 active site 714359012731 putative substrate binding region [chemical binding]; other site 714359012732 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 714359012733 active site 1 [active] 714359012734 dimer interface [polypeptide binding]; other site 714359012735 hexamer interface [polypeptide binding]; other site 714359012736 active site 2 [active] 714359012737 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 714359012738 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 714359012739 Zn2+ binding site [ion binding]; other site 714359012740 Mg2+ binding site [ion binding]; other site 714359012741 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 714359012742 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 714359012743 intersubunit interface [polypeptide binding]; other site 714359012744 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 714359012745 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 714359012746 Walker A/P-loop; other site 714359012747 ATP binding site [chemical binding]; other site 714359012748 Q-loop/lid; other site 714359012749 ABC transporter signature motif; other site 714359012750 Walker B; other site 714359012751 D-loop; other site 714359012752 H-loop/switch region; other site 714359012753 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 714359012754 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714359012755 ABC-ATPase subunit interface; other site 714359012756 dimer interface [polypeptide binding]; other site 714359012757 putative PBP binding regions; other site 714359012758 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 714359012759 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 714359012760 ABC-ATPase subunit interface; other site 714359012761 dimer interface [polypeptide binding]; other site 714359012762 putative PBP binding regions; other site 714359012763 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 714359012764 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 714359012765 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 714359012766 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 714359012767 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 714359012768 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 714359012769 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 714359012770 Chlorite dismutase; Region: Chlor_dismutase; cl01280 714359012771 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 714359012772 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359012773 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 714359012774 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; cl09881 714359012775 Protein of unknown function (DUF423); Region: DUF423; cl01008 714359012776 Ion channel; Region: Ion_trans_2; cl11596 714359012777 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 714359012778 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359012779 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 714359012780 Permease family; Region: Xan_ur_permease; cl00967 714359012781 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 714359012782 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359012783 motif II; other site 714359012784 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 714359012785 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 714359012786 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 714359012787 ligand binding site [chemical binding]; other site 714359012788 active site 714359012789 UGI interface [polypeptide binding]; other site 714359012790 catalytic site [active] 714359012791 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 714359012792 ABC-2 type transporter; Region: ABC2_membrane; cl11417 714359012793 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 714359012794 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 714359012795 Walker A/P-loop; other site 714359012796 ATP binding site [chemical binding]; other site 714359012797 Q-loop/lid; other site 714359012798 ABC transporter signature motif; other site 714359012799 Walker B; other site 714359012800 D-loop; other site 714359012801 H-loop/switch region; other site 714359012802 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 714359012803 active site 714359012804 catalytic triad [active] 714359012805 oxyanion hole [active] 714359012806 Transcriptional regulators [Transcription]; Region: PurR; COG1609 714359012807 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 714359012808 DNA binding site [nucleotide binding] 714359012809 domain linker motif; other site 714359012810 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 714359012811 putative dimerization interface [polypeptide binding]; other site 714359012812 putative ligand binding site [chemical binding]; other site 714359012813 Predicted membrane protein [Function unknown]; Region: COG2364 714359012814 homoserine dehydrogenase; Provisional; Region: PRK06349 714359012815 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359012816 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 714359012817 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 714359012818 homoserine O-succinyltransferase; Provisional; Region: PRK05368 714359012819 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 714359012820 proposed active site lysine [active] 714359012821 conserved cys residue [active] 714359012822 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06702 714359012823 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 714359012824 homodimer interface [polypeptide binding]; other site 714359012825 substrate-cofactor binding pocket; other site 714359012826 pyridoxal 5'-phosphate binding site [chemical binding]; other site 714359012827 catalytic residue [active] 714359012828 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 714359012829 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 714359012830 Cl- selectivity filter; other site 714359012831 Cl- binding residues [ion binding]; other site 714359012832 pore gating glutamate residue; other site 714359012833 dimer interface [polypeptide binding]; other site 714359012834 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 714359012835 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359012836 active site 714359012837 motif I; other site 714359012838 motif II; other site 714359012839 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 714359012840 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 714359012841 ligand binding site [chemical binding]; other site 714359012842 flexible hinge region; other site 714359012843 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 714359012844 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 714359012845 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359012846 active site 714359012847 phosphorylation site [posttranslational modification] 714359012848 intermolecular recognition site; other site 714359012849 dimerization interface [polypeptide binding]; other site 714359012850 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 714359012851 DNA binding residues [nucleotide binding] 714359012852 dimerization interface [polypeptide binding]; other site 714359012853 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 714359012854 GAF domain; Region: GAF; cl00853 714359012855 GAF domain; Region: GAF; cl00853 714359012856 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 714359012857 Histidine kinase; Region: HisKA_3; pfam07730 714359012858 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 714359012859 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 714359012860 dimer interface [polypeptide binding]; other site 714359012861 substrate binding site [chemical binding]; other site 714359012862 ATP binding site [chemical binding]; other site 714359012863 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 714359012864 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714359012865 metal binding site [ion binding]; metal-binding site 714359012866 active site 714359012867 I-site; other site 714359012868 Protein of unknown function (DUF466); Region: DUF466; cl01082 714359012869 Carbon starvation protein CstA; Region: CstA; cl00856 714359012870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359012871 active site 714359012872 phosphorylation site [posttranslational modification] 714359012873 intermolecular recognition site; other site 714359012874 dimerization interface [polypeptide binding]; other site 714359012875 LytTr DNA-binding domain; Region: LytTR; cl04498 714359012876 benzoate transport; Region: 2A0115; TIGR00895 714359012877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359012878 putative substrate translocation pore; other site 714359012879 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 714359012880 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 714359012881 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 714359012882 Predicted membrane protein [Function unknown]; Region: COG2860 714359012883 UPF0126 domain; Region: UPF0126; pfam03458 714359012884 UPF0126 domain; Region: UPF0126; pfam03458 714359012885 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 714359012886 heme-binding site [chemical binding]; other site 714359012887 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These transmembrane...; Region: TarH; cl00144 714359012888 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 714359012889 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 714359012890 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 714359012891 Ligand binding site; other site 714359012892 Putative Catalytic site; other site 714359012893 DXD motif; other site 714359012894 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 714359012895 active site 714359012896 MatE; Region: MatE; cl10513 714359012897 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 714359012898 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 714359012899 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 714359012900 Ligand binding site; other site 714359012901 Putative Catalytic site; other site 714359012902 DXD motif; other site 714359012903 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 714359012904 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 714359012905 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 714359012906 ABC transporter; Region: ABC_tran_2; pfam12848 714359012907 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 714359012908 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359012909 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359012910 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 714359012911 Protein export membrane protein; Region: SecD_SecF; cl14618 714359012912 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 714359012913 SelR domain; Region: SelR; cl00369 714359012914 Domain of unknown function DUF20; Region: UPF0118; cl00465 714359012915 LrgB-like family; Region: LrgB; cl00596 714359012916 LrgA family; Region: LrgA; cl00608 714359012917 two-component response regulator; Provisional; Region: PRK14084 714359012918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359012919 active site 714359012920 phosphorylation site [posttranslational modification] 714359012921 intermolecular recognition site; other site 714359012922 dimerization interface [polypeptide binding]; other site 714359012923 LytTr DNA-binding domain; Region: LytTR; cl04498 714359012924 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 714359012925 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 714359012926 GAF domain; Region: GAF; cl00853 714359012927 Histidine kinase; Region: His_kinase; pfam06580 714359012928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359012929 ATP binding site [chemical binding]; other site 714359012930 Mg2+ binding site [ion binding]; other site 714359012931 G-X-G motif; other site 714359012932 benzoate transport; Region: 2A0115; TIGR00895 714359012933 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 714359012934 putative substrate translocation pore; other site 714359012935 BCCT family transporter; Region: BCCT; cl00569 714359012936 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cl00254 714359012937 active site 714359012938 dimer interface [polypeptide binding]; other site 714359012939 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 714359012940 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 714359012941 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 714359012942 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 714359012943 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359012944 NAD(P) binding site [chemical binding]; other site 714359012945 active site 714359012946 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 714359012947 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 714359012948 UDP-glucose 4-epimerase; Region: PLN02240 714359012949 NAD binding site [chemical binding]; other site 714359012950 homodimer interface [polypeptide binding]; other site 714359012951 active site 714359012952 substrate binding site [chemical binding]; other site 714359012953 Haemolysin-III related; Region: HlyIII; cl03831 714359012954 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 714359012955 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 714359012956 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 714359012957 ATP binding site [chemical binding]; other site 714359012958 Mg++ binding site [ion binding]; other site 714359012959 motif III; other site 714359012960 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 714359012961 nucleotide binding region [chemical binding]; other site 714359012962 ATP-binding site [chemical binding]; other site 714359012963 DbpA RNA binding domain; Region: DbpA; pfam03880 714359012964 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 714359012965 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 714359012966 active site 714359012967 oligoendopeptidase F; Region: pepF; TIGR00181 714359012968 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 714359012969 active site 714359012970 Zn binding site [ion binding]; other site 714359012971 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 714359012972 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359012973 FeS/SAM binding site; other site 714359012974 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 714359012975 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 714359012976 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39B; cd02418 714359012977 putative active site [active] 714359012978 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 714359012979 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359012980 Walker A/P-loop; other site 714359012981 ATP binding site [chemical binding]; other site 714359012982 Q-loop/lid; other site 714359012983 ABC transporter signature motif; other site 714359012984 Walker B; other site 714359012985 D-loop; other site 714359012986 H-loop/switch region; other site 714359012987 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 714359012988 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 714359012989 Walker A/P-loop; other site 714359012990 ATP binding site [chemical binding]; other site 714359012991 Q-loop/lid; other site 714359012992 ABC transporter signature motif; other site 714359012993 Walker B; other site 714359012994 D-loop; other site 714359012995 H-loop/switch region; other site 714359012996 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 714359012997 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 714359012998 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 714359012999 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 714359013000 protein binding site [polypeptide binding]; other site 714359013001 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 714359013002 YycH protein; Region: YycI; cl02015 714359013003 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 714359013004 YycH protein; Region: YycH; pfam07435 714359013005 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 714359013006 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 714359013007 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359013008 dimerization interface [polypeptide binding]; other site 714359013009 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 714359013010 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359013011 dimer interface [polypeptide binding]; other site 714359013012 phosphorylation site [posttranslational modification] 714359013013 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359013014 ATP binding site [chemical binding]; other site 714359013015 Mg2+ binding site [ion binding]; other site 714359013016 G-X-G motif; other site 714359013017 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359013018 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359013019 active site 714359013020 phosphorylation site [posttranslational modification] 714359013021 intermolecular recognition site; other site 714359013022 dimerization interface [polypeptide binding]; other site 714359013023 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359013024 DNA binding site [nucleotide binding] 714359013025 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 714359013026 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 714359013027 GDP-binding site [chemical binding]; other site 714359013028 ACT binding site; other site 714359013029 IMP binding site; other site 714359013030 replicative DNA helicase; Provisional; Region: PRK05748 714359013031 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 714359013032 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 714359013033 Walker A motif; other site 714359013034 ATP binding site [chemical binding]; other site 714359013035 Walker B motif; other site 714359013036 DNA binding loops [nucleotide binding] 714359013037 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 714359013038 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 714359013039 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 714359013040 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 714359013041 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 714359013042 DHH family; Region: DHH; pfam01368 714359013043 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 714359013044 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 714359013045 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 714359013046 dimer interface [polypeptide binding]; other site 714359013047 ssDNA binding site [nucleotide binding]; other site 714359013048 tetramer (dimer of dimers) interface [polypeptide binding]; other site 714359013049 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 714359013050 GTP-binding protein YchF; Reviewed; Region: PRK09601 714359013051 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 714359013052 G1 box; other site 714359013053 GTP/Mg2+ binding site [chemical binding]; other site 714359013054 Switch I region; other site 714359013055 G2 box; other site 714359013056 Switch II region; other site 714359013057 G3 box; other site 714359013058 G4 box; other site 714359013059 G5 box; other site 714359013060 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 714359013061 Mechanosensitive ion channel; Region: MS_channel; pfam00924 714359013062 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 714359013063 ParB-like partition proteins; Region: parB_part; TIGR00180 714359013064 ParB-like nuclease domain; Region: ParBc; cl02129 714359013065 KorB domain; Region: KorB; pfam08535 714359013066 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 714359013067 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 714359013068 P-loop; other site 714359013069 Magnesium ion binding site [ion binding]; other site 714359013070 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 714359013071 Magnesium ion binding site [ion binding]; other site 714359013072 ParB-like partition proteins; Region: parB_part; TIGR00180 714359013073 ParB-like nuclease domain; Region: ParBc; cl02129 714359013074 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 714359013075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 714359013076 S-adenosylmethionine binding site [chemical binding]; other site 714359013077 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 714359013078 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440 714359013079 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 714359013080 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 714359013081 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 714359013082 G1 box; other site 714359013083 GTP/Mg2+ binding site [chemical binding]; other site 714359013084 Switch I region; other site 714359013085 G2 box; other site 714359013086 Switch II region; other site 714359013087 G3 box; other site 714359013088 G4 box; other site 714359013089 G5 box; other site 714359013090 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 714359013091 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 714359013092 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 714359013093 G-X-X-G motif; other site 714359013094 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 714359013095 RxxxH motif; other site 714359013096 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 714359013097 Ribonuclease P; Region: Ribonuclease_P; cl00457 714359013098 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 714359013099 Protein of unknown function (DUF523); Region: DUF523; cl00733 714359013100 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 714359013101 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359013102 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 714359013103 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl01099 714359013104 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 714359013105 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 714359013106 Predicted esterase [General function prediction only]; Region: COG0627 714359013107 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 714359013108 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 714359013109 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 714359013110 substrate binding site [chemical binding]; other site 714359013111 catalytic Zn binding site [ion binding]; other site 714359013112 NAD binding site [chemical binding]; other site 714359013113 structural Zn binding site [ion binding]; other site 714359013114 dimer interface [polypeptide binding]; other site 714359013115 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359013116 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 714359013117 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 714359013118 catalytic residues [active] 714359013119 catalytic nucleophile [active] 714359013120 Presynaptic Site I dimer interface [polypeptide binding]; other site 714359013121 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 714359013122 Synaptic Flat tetramer interface [polypeptide binding]; other site 714359013123 Synaptic Site I dimer interface [polypeptide binding]; other site 714359013124 DNA binding site [nucleotide binding] 714359013125 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 714359013126 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 714359013127 D3 - B interaction site; other site 714359013128 Hfq - Hfq interaction site; other site 714359013129 RNA binding pocket [nucleotide binding]; other site 714359013130 Sm2 motif; other site 714359013131 D1 - D2 interaction site; other site 714359013132 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 714359013133 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 714359013134 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 714359013135 multiple promoter invertase; Provisional; Region: mpi; PRK13413 714359013136 catalytic residues [active] 714359013137 catalytic nucleophile [active] 714359013138 Presynaptic Site I dimer interface [polypeptide binding]; other site 714359013139 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 714359013140 Synaptic Flat tetramer interface [polypeptide binding]; other site 714359013141 Synaptic Site I dimer interface [polypeptide binding]; other site 714359013142 DNA binding site [nucleotide binding] 714359013143 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359013144 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 714359013145 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 714359013146 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 714359013147 Amino acid permease; Region: AA_permease; cl00524 714359013148 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 714359013149 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 714359013150 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359013151 dimerization interface [polypeptide binding]; other site 714359013152 putative DNA binding site [nucleotide binding]; other site 714359013153 putative Zn2+ binding site [ion binding]; other site 714359013154 Protein of unknown function (DUF421); Region: DUF421; cl00990 714359013155 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 714359013156 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 714359013157 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 714359013158 multiple promoter invertase; Provisional; Region: mpi; PRK13413 714359013159 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 714359013160 catalytic residues [active] 714359013161 catalytic nucleophile [active] 714359013162 Presynaptic Site I dimer interface [polypeptide binding]; other site 714359013163 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 714359013164 Synaptic Flat tetramer interface [polypeptide binding]; other site 714359013165 Synaptic Site I dimer interface [polypeptide binding]; other site 714359013166 DNA binding site [nucleotide binding] 714359013167 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 714359013168 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 714359013169 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 714359013170 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 714359013171 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 714359013172 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 714359013173 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 714359013174 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 714359013175 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 714359013176 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 714359013177 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 714359013178 putative active site [active] 714359013179 putative NTP binding site [chemical binding]; other site 714359013180 putative nucleic acid binding site [nucleotide binding]; other site 714359013181 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 714359013182 active site 714359013183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359013184 ATP binding site [chemical binding]; other site 714359013185 PRTRC system protein B; Region: PRTRC_B; TIGR03737 714359013186 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 714359013187 Catalytic site [active] 714359013188 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 714359013189 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 714359013190 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 714359013191 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 714359013192 putative active site [active] 714359013193 putative NTP binding site [chemical binding]; other site 714359013194 putative nucleic acid binding site [nucleotide binding]; other site 714359013195 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 714359013196 active site 714359013197 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [Transcription]; Region: RpoD; COG0568 714359013198 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 714359013199 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 714359013200 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 714359013201 putative NTP binding site [chemical binding]; other site 714359013202 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl15461 714359013203 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359013204 non-specific DNA binding site [nucleotide binding]; other site 714359013205 salt bridge; other site 714359013206 sequence-specific DNA binding site [nucleotide binding]; other site 714359013207 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 714359013208 DNA polymerase III subunit beta; Validated; Region: PRK05643 714359013209 putative DNA binding surface [nucleotide binding]; other site 714359013210 dimer interface [polypeptide binding]; other site 714359013211 beta-clamp/translesion DNA polymerase binding surface; other site 714359013212 beta-clamp/clamp loader binding surface; other site 714359013213 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 714359013214 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 714359013215 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 714359013216 nucleotide binding site [chemical binding]; other site 714359013217 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359013218 AAA-like domain; Region: AAA_10; pfam12846 714359013219 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl14888 714359013220 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 714359013221 Int/Topo IB signature motif; other site 714359013222 active site 714359013223 DNA binding site [nucleotide binding] 714359013224 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 714359013225 Trp repressor protein; Region: Trp_repressor; cl01121 714359013226 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 714359013227 TcpE family; Region: TcpE; pfam12648 714359013228 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 714359013229 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 714359013230 putative active site [active] 714359013231 putative NTP binding site [chemical binding]; other site 714359013232 putative nucleic acid binding site [nucleotide binding]; other site 714359013233 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 714359013234 active site 714359013235 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 714359013236 AAA-like domain; Region: AAA_10; pfam12846 714359013237 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 714359013238 Atrophin-1 family; Region: Atrophin-1; pfam03154 714359013239 Protein of unknown function (DUF3295); Region: DUF3295; pfam11702 714359013240 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 714359013241 N-acetyl-D-glucosamine binding site [chemical binding]; other site 714359013242 catalytic residue [active] 714359013243 NlpC/P60 family; Region: NLPC_P60; cl11438 714359013244 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 714359013245 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 714359013246 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 714359013247 RNA binding site [nucleotide binding]; other site 714359013248 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 714359013249 nucleophile elbow; other site 714359013250 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 714359013251 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 714359013252 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 714359013253 5-methylcytosine-specific restriction enzyme subunit McrB; Provisional; Region: PRK11331 714359013254 5-methylcytosine-specific restriction enzyme subunit McrB; Provisional; Region: PRK11331 714359013255 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 714359013256 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 714359013257 MPN+ (JAMM) motif; other site 714359013258 Zinc-binding site [ion binding]; other site 714359013259 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 714359013260 potential frameshift: common BLAST hit: gi|67078174|ref|YP_245794.1| myo-inositol catabolism protein 714359013261 KduI/IolB family; Region: KduI; cl01508 714359013262 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 714359013263 active site 714359013264 catalytic residues [active] 714359013265 Protein of unknown function (DUF3796); Region: DUF3796; pfam12676 714359013266 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359013267 non-specific DNA binding site [nucleotide binding]; other site 714359013268 salt bridge; other site 714359013269 sequence-specific DNA binding site [nucleotide binding]; other site 714359013270 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 714359013271 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 714359013272 Walker A motif; other site 714359013273 ATP binding site [chemical binding]; other site 714359013274 Walker B motif; other site 714359013275 arginine finger; other site 714359013276 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 714359013277 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 714359013278 Probable transposase; Region: OrfB_IS605; pfam01385 714359013279 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 714359013280 proteasome-activating nucleotidase; Provisional; Region: PRK03992 714359013281 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 714359013282 DNA polymerase III subunit delta'; Validated; Region: PRK08058 714359013283 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359013284 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 714359013285 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 714359013286 Probable transposase; Region: OrfB_IS605; pfam01385 714359013287 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 714359013288 DNA topoisomerase III; Provisional; Region: PRK07726 714359013289 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 714359013290 active site 714359013291 putative interdomain interaction site [polypeptide binding]; other site 714359013292 putative metal-binding site [ion binding]; other site 714359013293 putative nucleotide binding site [chemical binding]; other site 714359013294 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 714359013295 domain I; other site 714359013296 DNA binding groove [nucleotide binding] 714359013297 phosphate binding site [ion binding]; other site 714359013298 domain II; other site 714359013299 domain III; other site 714359013300 nucleotide binding site [chemical binding]; other site 714359013301 catalytic site [active] 714359013302 domain IV; other site 714359013303 DNA topoisomerase III; Validated; Region: PRK08173 714359013304 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 714359013305 metal ion-dependent adhesion site (MIDAS); other site 714359013306 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 714359013307 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 714359013308 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 714359013309 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 714359013310 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 714359013311 TPR motif; other site 714359013312 binding surface 714359013313 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 714359013314 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359013315 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 714359013316 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359013317 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 714359013318 catalytic residues [active] 714359013319 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 714359013320 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 714359013321 PYR/PP interface [polypeptide binding]; other site 714359013322 dimer interface [polypeptide binding]; other site 714359013323 TPP binding site [chemical binding]; other site 714359013324 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 714359013325 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 714359013326 TPP-binding site [chemical binding]; other site 714359013327 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 714359013328 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359013329 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 714359013330 active site 714359013331 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 714359013332 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 714359013333 dimer interface [polypeptide binding]; other site 714359013334 active site 714359013335 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 714359013336 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 714359013337 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 714359013338 Walker A/P-loop; other site 714359013339 ATP binding site [chemical binding]; other site 714359013340 Q-loop/lid; other site 714359013341 ABC transporter signature motif; other site 714359013342 Walker B; other site 714359013343 D-loop; other site 714359013344 H-loop/switch region; other site 714359013345 peptide synthase; Provisional; Region: PRK12467 714359013346 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359013347 Phosphopantetheine attachment site; Region: PP-binding; cl09936 714359013348 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359013349 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359013350 Phosphopantetheine attachment site; Region: PP-binding; cl09936 714359013351 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 714359013352 peptide synthase; Provisional; Region: PRK12316 714359013353 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359013354 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359013355 Phosphopantetheine attachment site; Region: PP-binding; cl09936 714359013356 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359013357 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359013358 Phosphopantetheine attachment site; Region: PP-binding; cl09936 714359013359 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 714359013360 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359013361 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 714359013362 Phosphopantetheine attachment site; Region: PP-binding; cl09936 714359013363 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 714359013364 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 714359013365 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359013366 NAD(P) binding site [chemical binding]; other site 714359013367 active site 714359013368 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 714359013369 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359013370 Walker A/P-loop; other site 714359013371 ATP binding site [chemical binding]; other site 714359013372 Q-loop/lid; other site 714359013373 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 714359013374 ABC transporter signature motif; other site 714359013375 Walker B; other site 714359013376 D-loop; other site 714359013377 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 714359013378 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 714359013379 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 714359013380 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 714359013381 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 714359013382 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359013383 dimerization interface [polypeptide binding]; other site 714359013384 putative DNA binding site [nucleotide binding]; other site 714359013385 putative Zn2+ binding site [ion binding]; other site 714359013386 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 714359013387 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 714359013388 Probable transposase; Region: OrfB_IS605; pfam01385 714359013389 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 714359013390 Transposase IS200 like; Region: Y1_Tnp; cl00848 714359013391 PAS domain S-box; Region: sensory_box; TIGR00229 714359013392 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 714359013393 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 714359013394 metal binding site [ion binding]; metal-binding site 714359013395 active site 714359013396 I-site; other site 714359013397 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 714359013398 Domain of Unknown Function with PDB structure; Region: DUF3862; pfam12978 714359013399 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359013400 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 714359013401 heme-binding site [chemical binding]; other site 714359013402 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 714359013403 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These transmembrane...; Region: TarH; cl00144 714359013404 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 714359013405 active site 714359013406 catalytic residues [active] 714359013407 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 714359013408 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 714359013409 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359013410 ATP binding site [chemical binding]; other site 714359013411 dimerization interface [polypeptide binding]; other site 714359013412 Metal binding site [ion binding]; metal-binding site 714359013413 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 714359013414 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359013415 ATP binding site [chemical binding]; other site 714359013416 dimerization interface [polypeptide binding]; other site 714359013417 Metal binding site [ion binding]; metal-binding site 714359013418 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 714359013419 Low molecular weight phosphatase family; Region: LMWPc; cd00115 714359013420 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 714359013421 active site 714359013422 Membrane transport protein; Region: Mem_trans; cl09117 714359013423 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359013424 dimerization interface [polypeptide binding]; other site 714359013425 putative DNA binding site [nucleotide binding]; other site 714359013426 putative Zn2+ binding site [ion binding]; other site 714359013427 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 714359013428 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359013429 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 714359013430 G4 box; other site 714359013431 G5 box; other site 714359013432 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 714359013433 amphipathic channel; other site 714359013434 Asn-Pro-Ala signature motifs; other site 714359013435 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 714359013436 Radical SAM superfamily; Region: Radical_SAM; pfam04055 714359013437 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 714359013438 FeS/SAM binding site; other site 714359013439 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359013440 non-specific DNA binding site [nucleotide binding]; other site 714359013441 salt bridge; other site 714359013442 sequence-specific DNA binding site [nucleotide binding]; other site 714359013443 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 714359013444 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 714359013445 TPR motif; other site 714359013446 binding surface 714359013447 Phosphate transporter family; Region: PHO4; cl00396 714359013448 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 714359013449 dimerization interface [polypeptide binding]; other site 714359013450 putative DNA binding site [nucleotide binding]; other site 714359013451 putative Zn2+ binding site [ion binding]; other site 714359013452 argininosuccinate lyase; Provisional; Region: PRK02186 714359013453 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 714359013454 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 714359013455 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 714359013456 Predicted permease; Region: DUF318; cl00487 714359013457 Cdc6-related protein, AAA superfamily ATPase [DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones]; Region: CDC6; COG1474 714359013458 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; cl07370 714359013459 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 714359013460 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 714359013461 metal-binding site [ion binding] 714359013462 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 714359013463 metal-binding site [ion binding] 714359013464 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 714359013465 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 714359013466 metal-binding site [ion binding] 714359013467 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 714359013468 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 714359013469 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 714359013470 putative homotetramer interface [polypeptide binding]; other site 714359013471 putative homodimer interface [polypeptide binding]; other site 714359013472 putative allosteric switch controlling residues; other site 714359013473 putative metal binding site [ion binding]; other site 714359013474 putative homodimer-homodimer interface [polypeptide binding]; other site 714359013475 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 714359013476 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 714359013477 metal binding site [ion binding]; metal-binding site 714359013478 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 714359013479 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 714359013480 catalytic residues [active] 714359013481 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 714359013482 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 714359013483 dimerization interface [polypeptide binding]; other site 714359013484 VPS10 domain; Region: VPS10; smart00602 714359013485 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 714359013486 Protein of unknown function (DUF1326); Region: DUF1326; cl02375 714359013487 Bacterial SH3 domain; Region: SH3_3; cl02551 714359013488 Bacterial SH3 domain; Region: SH3_3; cl02551 714359013489 Bacterial SH3 domain; Region: SH3_3; cl02551 714359013490 Bacterial SH3 domain; Region: SH3_3; cl02551 714359013491 DNA translocase FtsK; Provisional; Region: PRK10263 714359013492 Bacterial SH3 domain; Region: SH3_3; cl02551 714359013493 Peptidase family M23; Region: Peptidase_M23; pfam01551 714359013494 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 714359013495 catalytic residues [active] 714359013496 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 714359013497 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 714359013498 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 714359013499 substrate binding pocket [chemical binding]; other site 714359013500 membrane-bound complex binding site; other site 714359013501 hinge residues; other site 714359013502 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 714359013503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 714359013504 dimer interface [polypeptide binding]; other site 714359013505 conserved gate region; other site 714359013506 putative PBP binding loops; other site 714359013507 ABC-ATPase subunit interface; other site 714359013508 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 714359013509 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 714359013510 Walker A/P-loop; other site 714359013511 ATP binding site [chemical binding]; other site 714359013512 Q-loop/lid; other site 714359013513 ABC transporter signature motif; other site 714359013514 Walker B; other site 714359013515 D-loop; other site 714359013516 H-loop/switch region; other site 714359013517 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 714359013518 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 714359013519 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 714359013520 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 714359013521 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 714359013522 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359013523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359013524 active site 714359013525 phosphorylation site [posttranslational modification] 714359013526 intermolecular recognition site; other site 714359013527 dimerization interface [polypeptide binding]; other site 714359013528 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359013529 DNA binding site [nucleotide binding] 714359013530 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 714359013531 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 714359013532 dimerization interface [polypeptide binding]; other site 714359013533 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 714359013534 dimer interface [polypeptide binding]; other site 714359013535 phosphorylation site [posttranslational modification] 714359013536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 714359013537 ATP binding site [chemical binding]; other site 714359013538 Mg2+ binding site [ion binding]; other site 714359013539 G-X-G motif; other site 714359013540 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 714359013541 stage II sporulation protein P; Region: spore_II_P; TIGR02867 714359013542 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 714359013543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 714359013544 active site 714359013545 phosphorylation site [posttranslational modification] 714359013546 intermolecular recognition site; other site 714359013547 dimerization interface [polypeptide binding]; other site 714359013548 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 714359013549 DNA binding site [nucleotide binding] 714359013550 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 714359013551 putative active site [active] 714359013552 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 714359013553 catalytic triad [active] 714359013554 conserved cis-peptide bond; other site 714359013555 Domain of unknown function DUF11; Region: DUF11; cl15273 714359013556 Domain of unknown function DUF11; Region: DUF11; cl15273 714359013557 Domain of unknown function DUF11; Region: DUF11; cl15273 714359013558 Domain of unknown function DUF11; Region: DUF11; cl15273 714359013559 Domain of unknown function DUF11; Region: DUF11; cl15273 714359013560 Domain of unknown function DUF11; Region: DUF11; cl15273 714359013561 Domain of unknown function DUF11; Region: DUF11; cl15273 714359013562 Domain of unknown function DUF11; Region: DUF11; cl15273 714359013563 Domain of unknown function DUF11; Region: DUF11; cl15273 714359013564 Domain of unknown function DUF11; Region: DUF11; cl15273 714359013565 Domain of unknown function DUF11; Region: DUF11; cl15273 714359013566 Domain of unknown function DUF11; Region: DUF11; cl15273 714359013567 Domain of unknown function DUF11; Region: DUF11; cl15273 714359013568 Domain of unknown function DUF11; Region: DUF11; cl15273 714359013569 Domain of unknown function DUF11; Region: DUF11; cl15273 714359013570 Domain of unknown function DUF11; Region: DUF11; cl15273 714359013571 Domain of unknown function DUF11; Region: DUF11; cl15273 714359013572 Domain of unknown function DUF11; Region: DUF11; cl15273 714359013573 Domain of unknown function DUF11; Region: DUF11; cl15273 714359013574 Domain of unknown function DUF11; Region: DUF11; cl15273 714359013575 Domain of unknown function DUF11; Region: DUF11; cl15273 714359013576 Domain of unknown function DUF11; Region: DUF11; cl15273 714359013577 Domain of unknown function DUF11; Region: DUF11; cl15273 714359013578 Domain of unknown function DUF11; Region: DUF11; cl15273 714359013579 Domain of unknown function DUF11; Region: DUF11; cl15273 714359013580 Domain of unknown function DUF11; Region: DUF11; cl15273 714359013581 Domain of unknown function DUF11; Region: DUF11; cl15273 714359013582 Domain of unknown function DUF11; Region: DUF11; cl15273 714359013583 Domain of unknown function DUF11; Region: DUF11; cl15273 714359013584 Domain of unknown function DUF11; Region: DUF11; cl15273 714359013585 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 714359013586 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 714359013587 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 714359013588 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 714359013589 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 714359013590 non-specific DNA binding site [nucleotide binding]; other site 714359013591 salt bridge; other site 714359013592 sequence-specific DNA binding site [nucleotide binding]; other site 714359013593 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 714359013594 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 714359013595 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 714359013596 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 714359013597 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 714359013598 active site 714359013599 motif I; other site 714359013600 motif II; other site 714359013601 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 714359013602 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 714359013603 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 714359013604 DNA binding site [nucleotide binding] 714359013605 Int/Topo IB signature motif; other site 714359013606 active site 714359013607 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 714359013608 DNA binding residues [nucleotide binding] 714359013609 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 714359013610 DNA binding residues [nucleotide binding] 714359013611 Domain of unknown function (DUF74); Region: DUF74; cl00426