-- dump date 20120504_134440 -- class Genbank::misc_feature -- table misc_feature_note -- id note 315730000001 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 315730000002 putative peptidoglycan binding site; other site 315730000003 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 315730000004 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 315730000005 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 315730000006 Domain of unknown function (DUF4376); Region: DUF4376; pfam14301 315730000007 Coronavirus S2 glycoprotein; Region: Corona_S2; pfam01601 315730000008 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 315730000009 FtsX-like permease family; Region: FtsX; cl15850 315730000010 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730000011 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 315730000012 Walker A/P-loop; other site 315730000013 ATP binding site [chemical binding]; other site 315730000014 Q-loop/lid; other site 315730000015 ABC transporter signature motif; other site 315730000016 Walker B; other site 315730000017 D-loop; other site 315730000018 H-loop/switch region; other site 315730000019 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315730000020 Helix-turn-helix domains; Region: HTH; cl00088 315730000021 Helix-turn-helix domains; Region: HTH; cl00088 315730000022 Alpha/beta hydrolase of unknown function (DUF1100); Region: DUF1100; pfam06500 315730000023 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315730000024 Helix-turn-helix domains; Region: HTH; cl00088 315730000025 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315730000026 dimerization interface [polypeptide binding]; other site 315730000027 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 315730000028 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 315730000029 S-methylmethionine transporter; Provisional; Region: PRK11387 315730000030 Spore germination protein; Region: Spore_permease; cl15802 315730000031 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 315730000032 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 315730000033 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 315730000034 amidase catalytic site [active] 315730000035 Zn binding residues [ion binding]; other site 315730000036 substrate binding site [chemical binding]; other site 315730000037 S-layer homology domain; Region: SLH; pfam00395 315730000038 S-layer homology domain; Region: SLH; pfam00395 315730000039 S-layer homology domain; Region: SLH; pfam00395 315730000040 Bacterial SH3 domain; Region: SH3_3; cl02551 315730000041 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 315730000042 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 315730000043 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 315730000044 protein binding site [polypeptide binding]; other site 315730000045 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730000046 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730000047 dimerization interface [polypeptide binding]; other site 315730000048 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730000049 dimer interface [polypeptide binding]; other site 315730000050 phosphorylation site [posttranslational modification] 315730000051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730000052 ATP binding site [chemical binding]; other site 315730000053 Mg2+ binding site [ion binding]; other site 315730000054 G-X-G motif; other site 315730000055 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 315730000056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730000057 active site 315730000058 phosphorylation site [posttranslational modification] 315730000059 intermolecular recognition site; other site 315730000060 dimerization interface [polypeptide binding]; other site 315730000061 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730000062 DNA binding site [nucleotide binding] 315730000063 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 315730000064 putative active site [active] 315730000065 putative catalytic triad [active] 315730000066 Viral enhancin protein; Region: Enhancin; pfam03272 315730000067 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 315730000068 Interdomain contacts; other site 315730000069 Cytokine receptor motif; other site 315730000070 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 315730000071 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 315730000072 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730000073 dimerization interface [polypeptide binding]; other site 315730000074 putative DNA binding site [nucleotide binding]; other site 315730000075 putative Zn2+ binding site [ion binding]; other site 315730000076 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 315730000077 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 315730000078 catalytic residues [active] 315730000079 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 315730000080 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315730000081 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 315730000082 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 315730000083 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 315730000084 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 315730000085 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 315730000086 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 315730000087 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 315730000088 catalytic residue [active] 315730000089 peptide synthase; Provisional; Region: PRK12467 315730000090 AMP-binding enzyme; Region: AMP-binding; cl15778 315730000091 peptide synthase; Provisional; Region: PRK12467 315730000092 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315730000093 Condensation domain; Region: Condensation; pfam00668 315730000094 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 315730000095 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315730000096 AMP-binding enzyme; Region: AMP-binding; cl15778 315730000097 acyl-CoA synthetase; Validated; Region: PRK08308 315730000098 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315730000099 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 315730000100 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 315730000101 putative NAD(P) binding site [chemical binding]; other site 315730000102 active site 315730000103 putative substrate binding site [chemical binding]; other site 315730000104 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315730000105 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 315730000106 Walker A/P-loop; other site 315730000107 ATP binding site [chemical binding]; other site 315730000108 Q-loop/lid; other site 315730000109 ABC transporter signature motif; other site 315730000110 Walker B; other site 315730000111 D-loop; other site 315730000112 H-loop/switch region; other site 315730000113 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 315730000114 TPR motif; other site 315730000115 binding surface 315730000116 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315730000117 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730000118 Coenzyme A binding pocket [chemical binding]; other site 315730000119 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730000120 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315730000121 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 315730000122 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 315730000123 Proteins of 100 residues with WXG; Region: WXG100; cl02005 315730000124 VanW like protein; Region: VanW; pfam04294 315730000125 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730000126 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 315730000127 active site 315730000128 metal binding site [ion binding]; metal-binding site 315730000129 DDE domain; Region: DDE_Tnp_IS240; pfam13610 315730000130 Integrase core domain; Region: rve; cl01316 315730000131 Clostridial binary toxin B/anthrax toxin PA; Region: Binary_toxB; pfam03495 315730000132 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730000133 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730000134 active site 315730000135 phosphorylation site [posttranslational modification] 315730000136 intermolecular recognition site; other site 315730000137 dimerization interface [polypeptide binding]; other site 315730000138 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730000139 DNA binding site [nucleotide binding] 315730000140 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730000141 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 315730000142 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730000143 dimer interface [polypeptide binding]; other site 315730000144 phosphorylation site [posttranslational modification] 315730000145 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730000146 ATP binding site [chemical binding]; other site 315730000147 Mg2+ binding site [ion binding]; other site 315730000148 G-X-G motif; other site 315730000149 Electron transfer DM13; Region: DM13; cl02735 315730000150 Uncharacterized conserved protein [Function unknown]; Region: COG5276 315730000151 OpgC protein; Region: OpgC_C; cl00792 315730000152 Acyltransferase family; Region: Acyl_transf_3; pfam01757 315730000153 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 315730000154 catalytic triad [active] 315730000155 catalytic triad [active] 315730000156 oxyanion hole [active] 315730000157 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 315730000158 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 315730000159 homotrimer interaction site [polypeptide binding]; other site 315730000160 putative active site [active] 315730000161 Recombination protein U; Region: RecU; cl01314 315730000162 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 315730000163 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 315730000164 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 315730000165 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 315730000166 DNA binding site [nucleotide binding] 315730000167 Int/Topo IB signature motif; other site 315730000168 active site 315730000169 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 315730000170 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 315730000171 DNA binding site [nucleotide binding] 315730000172 Int/Topo IB signature motif; other site 315730000173 active site 315730000174 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 315730000175 catalytic residues [active] 315730000176 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 315730000177 Sm1 motif; other site 315730000178 D3 - B interaction site; other site 315730000179 D1 - D2 interaction site; other site 315730000180 Hfq - Hfq interaction site; other site 315730000181 RNA binding pocket [nucleotide binding]; other site 315730000182 Sm2 motif; other site 315730000183 delta endotoxin, N-terminal domain; Region: Endotoxin_N; pfam03945 315730000184 delta endotoxin; Region: Endotoxin_M; pfam00555 315730000185 delta-endotoxin C-terminal domain may be associated with carbohydrate binding functionality; Region: delta_endotoxin_C; cd04085 315730000186 putative metal binding site [ion binding]; other site 315730000187 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 315730000188 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315730000189 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315730000190 Helix-turn-helix domains; Region: HTH; cl00088 315730000191 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315730000192 dimerization interface [polypeptide binding]; other site 315730000193 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 315730000194 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 315730000195 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730000196 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 315730000197 Walker A/P-loop; other site 315730000198 ATP binding site [chemical binding]; other site 315730000199 Q-loop/lid; other site 315730000200 ABC transporter signature motif; other site 315730000201 Walker B; other site 315730000202 D-loop; other site 315730000203 H-loop/switch region; other site 315730000204 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 315730000205 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 315730000206 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 315730000207 Walker A/P-loop; other site 315730000208 ATP binding site [chemical binding]; other site 315730000209 Q-loop/lid; other site 315730000210 ABC transporter signature motif; other site 315730000211 Walker B; other site 315730000212 D-loop; other site 315730000213 H-loop/switch region; other site 315730000214 ABC-2 type transporter; Region: ABC2_membrane; cl11417 315730000215 NosL; Region: NosL; cl01769 315730000216 Nitrous oxidase accessory protein [Inorganic ion transport and metabolism]; Region: NosD; COG3420 315730000217 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 315730000218 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 315730000219 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 315730000220 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 315730000221 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 315730000222 trimer interface [polypeptide binding]; other site 315730000223 active site 315730000224 CoA binding site [chemical binding]; other site 315730000225 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730000226 dimerization interface [polypeptide binding]; other site 315730000227 putative DNA binding site [nucleotide binding]; other site 315730000228 putative Zn2+ binding site [ion binding]; other site 315730000229 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 315730000230 EamA-like transporter family; Region: EamA; cl01037 315730000231 EamA-like transporter family; Region: EamA; cl01037 315730000232 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 315730000233 classical (c) SDRs; Region: SDR_c; cd05233 315730000234 NAD(P) binding site [chemical binding]; other site 315730000235 active site 315730000236 Biofilm formation and stress response factor; Region: BsmA; cl01794 315730000237 Cupin domain; Region: Cupin_2; cl09118 315730000238 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 315730000239 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 315730000240 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 315730000241 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 315730000242 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 315730000243 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 315730000244 Spore germination protein; Region: Spore_permease; cl15802 315730000245 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 315730000246 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 315730000247 RNA polymerase sigma factor; Provisional; Region: PRK12543 315730000248 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730000249 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730000250 DNA binding residues [nucleotide binding] 315730000251 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 315730000252 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730000253 Helix-turn-helix domains; Region: HTH; cl00088 315730000254 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 315730000255 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 315730000256 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 315730000257 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 315730000258 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 315730000259 PKC phosphorylation site [posttranslational modification]; other site 315730000260 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730000261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730000262 active site 315730000263 phosphorylation site [posttranslational modification] 315730000264 intermolecular recognition site; other site 315730000265 dimerization interface [polypeptide binding]; other site 315730000266 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730000267 DNA binding site [nucleotide binding] 315730000268 YrzO-like protein; Region: YrzO; pfam14142 315730000269 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 315730000270 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 315730000271 NodB motif; other site 315730000272 active site 315730000273 catalytic site [active] 315730000274 Zn binding site [ion binding]; other site 315730000275 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 315730000276 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 315730000277 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730000278 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 315730000279 Helix-turn-helix domains; Region: HTH; cl00088 315730000280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730000281 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730000282 putative substrate translocation pore; other site 315730000283 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730000284 Helix-turn-helix domains; Region: HTH; cl00088 315730000285 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 315730000286 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 315730000287 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 315730000288 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 315730000289 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315730000290 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 315730000291 DNA binding site [nucleotide binding] 315730000292 Int/Topo IB signature motif; other site 315730000293 active site 315730000294 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 315730000295 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315730000296 DNA binding residues [nucleotide binding] 315730000297 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 315730000298 DNA binding residues [nucleotide binding] 315730000299 Protein of unknown function (DUF975); Region: DUF975; cl10504 315730000300 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730000301 dimerization interface [polypeptide binding]; other site 315730000302 putative DNA binding site [nucleotide binding]; other site 315730000303 putative Zn2+ binding site [ion binding]; other site 315730000304 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730000305 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 315730000306 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 315730000307 FAD binding domain; Region: FAD_binding_4; pfam01565 315730000308 Berberine and berberine like; Region: BBE; pfam08031 315730000309 DDE domain; Region: DDE_Tnp_IS240; pfam13610 315730000310 Integrase core domain; Region: rve; cl01316 315730000311 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 315730000312 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 315730000313 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 315730000314 peptide synthase; Provisional; Region: PRK12316 315730000315 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315730000316 AMP-binding enzyme; Region: AMP-binding; cl15778 315730000317 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315730000318 peptide synthase; Provisional; Region: PRK12467 315730000319 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315730000320 AMP-binding enzyme; Region: AMP-binding; cl15778 315730000321 AMP-binding enzyme; Region: AMP-binding; cl15778 315730000322 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315730000323 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315730000324 AMP-binding enzyme; Region: AMP-binding; cl15778 315730000325 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315730000326 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 315730000327 AMP-binding enzyme; Region: AMP-binding; cl15778 315730000328 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315730000329 peptide synthase; Provisional; Region: PRK12467 315730000330 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315730000331 AMP-binding enzyme; Region: AMP-binding; cl15778 315730000332 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315730000333 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 315730000334 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315730000335 AMP-binding enzyme; Region: AMP-binding; cl15778 315730000336 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315730000337 peptide synthase; Provisional; Region: PRK12467 315730000338 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315730000339 AMP-binding enzyme; Region: AMP-binding; cl15778 315730000340 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315730000341 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 315730000342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730000343 H+ Antiporter protein; Region: 2A0121; TIGR00900 315730000344 putative substrate translocation pore; other site 315730000345 DDE domain; Region: DDE_Tnp_IS240; pfam13610 315730000346 Integrase core domain; Region: rve; cl01316 315730000347 Domain of unknown function (DUF3472); Region: DUF3472; pfam11958 315730000348 Viral enhancin protein; Region: Enhancin; pfam03272 315730000349 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 315730000350 Interdomain contacts; other site 315730000351 Cytokine receptor motif; other site 315730000352 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 315730000353 Peptidase M60-like family; Region: M60-like; pfam13402 315730000354 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 315730000355 Interdomain contacts; other site 315730000356 Cytokine receptor motif; other site 315730000357 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 315730000358 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 315730000359 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 315730000360 catalytic residues [active] 315730000361 catalytic nucleophile [active] 315730000362 Presynaptic Site I dimer interface [polypeptide binding]; other site 315730000363 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 315730000364 Synaptic Flat tetramer interface [polypeptide binding]; other site 315730000365 Synaptic Site I dimer interface [polypeptide binding]; other site 315730000366 DNA binding site [nucleotide binding] 315730000367 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 315730000368 Sm1 motif; other site 315730000369 D3 - B interaction site; other site 315730000370 D1 - D2 interaction site; other site 315730000371 Hfq - Hfq interaction site; other site 315730000372 RNA binding pocket [nucleotide binding]; other site 315730000373 Sm2 motif; other site 315730000374 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 315730000375 active site 315730000376 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 315730000377 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 315730000378 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 315730000379 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 315730000380 Transglycosylase; Region: Transgly; cl07896 315730000381 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 315730000382 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730000383 tetracycline repressor protein TetR; Provisional; Region: PRK13756 315730000384 Helix-turn-helix domains; Region: HTH; cl00088 315730000385 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 315730000386 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 315730000387 MatE; Region: MatE; cl10513 315730000388 MatE; Region: MatE; cl10513 315730000389 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730000390 non-specific DNA binding site [nucleotide binding]; other site 315730000391 salt bridge; other site 315730000392 sequence-specific DNA binding site [nucleotide binding]; other site 315730000393 Helix-turn-helix domains; Region: HTH; cl00088 315730000394 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730000395 DNA-binding site [nucleotide binding]; DNA binding site 315730000396 fatty acid metabolism transcriptional regulator FadR; Region: fadR_gamma; TIGR02812 315730000397 FCD domain; Region: FCD; cl11656 315730000398 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 315730000399 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 315730000400 nucleotide binding site [chemical binding]; other site 315730000401 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 315730000402 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 315730000403 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 315730000404 PAS fold; Region: PAS_4; pfam08448 315730000405 PAS domain S-box; Region: sensory_box; TIGR00229 315730000406 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315730000407 putative active site [active] 315730000408 heme pocket [chemical binding]; other site 315730000409 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 315730000410 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 315730000411 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730000412 dimer interface [polypeptide binding]; other site 315730000413 phosphorylation site [posttranslational modification] 315730000414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730000415 ATP binding site [chemical binding]; other site 315730000416 Mg2+ binding site [ion binding]; other site 315730000417 G-X-G motif; other site 315730000418 CAAX protease self-immunity; Region: Abi; cl00558 315730000419 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 315730000420 dimer interface [polypeptide binding]; other site 315730000421 FMN binding site [chemical binding]; other site 315730000422 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 315730000423 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 315730000424 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 315730000425 DDE domain; Region: DDE_Tnp_IS240; pfam13610 315730000426 Integrase core domain; Region: rve; cl01316 315730000427 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315730000428 DNA binding site [nucleotide binding] 315730000429 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730000430 Replication-relaxation; Region: Replic_Relax; pfam13814 315730000431 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 315730000432 DDE domain; Region: DDE_Tnp_IS240; pfam13610 315730000433 Integrase core domain; Region: rve; cl01316 315730000434 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 315730000435 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 315730000436 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730000437 Coenzyme A binding pocket [chemical binding]; other site 315730000438 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 315730000439 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 315730000440 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730000441 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 315730000442 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 315730000443 inhibitor-cofactor binding pocket; inhibition site 315730000444 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730000445 catalytic residue [active] 315730000446 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 315730000447 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730000448 NAD(P) binding site [chemical binding]; other site 315730000449 active site 315730000450 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 315730000451 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 315730000452 catalytic residue [active] 315730000453 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730000454 WbqC-like protein family; Region: WbqC; pfam08889 315730000455 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 315730000456 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 315730000457 Metal-binding active site; metal-binding site 315730000458 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 315730000459 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 315730000460 PA/protease or protease-like domain interface [polypeptide binding]; other site 315730000461 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 315730000462 metal binding site [ion binding]; metal-binding site 315730000463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730000464 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730000465 putative substrate translocation pore; other site 315730000466 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 315730000467 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 315730000468 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 315730000469 putative active site [active] 315730000470 putative catalytic triad [active] 315730000471 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 315730000472 active site 315730000473 NTP binding site [chemical binding]; other site 315730000474 metal binding triad [ion binding]; metal-binding site 315730000475 antibiotic binding site [chemical binding]; other site 315730000476 Protein of unknown function DUF86; Region: DUF86; cl01031 315730000477 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730000478 Helix-turn-helix domains; Region: HTH; cl00088 315730000479 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 315730000480 active site 315730000481 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 315730000482 dimer interface [polypeptide binding]; other site 315730000483 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 315730000484 Ligand Binding Site [chemical binding]; other site 315730000485 Molecular Tunnel; other site 315730000486 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730000487 Coenzyme A binding pocket [chemical binding]; other site 315730000488 Domain of unknown function (DUF4083); Region: DUF4083; pfam13314 315730000489 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 315730000490 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 315730000491 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730000492 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 315730000493 IHF dimer interface [polypeptide binding]; other site 315730000494 IHF - DNA interface [nucleotide binding]; other site 315730000495 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 315730000496 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730000497 non-specific DNA binding site [nucleotide binding]; other site 315730000498 salt bridge; other site 315730000499 sequence-specific DNA binding site [nucleotide binding]; other site 315730000500 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 315730000501 TPR motif; other site 315730000502 binding surface 315730000503 YolD-like protein; Region: YolD; pfam08863 315730000504 Helix-turn-helix domains; Region: HTH; cl00088 315730000505 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 315730000506 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 315730000507 amidase catalytic site [active] 315730000508 Zn binding residues [ion binding]; other site 315730000509 substrate binding site [chemical binding]; other site 315730000510 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 315730000511 Bacterial SH3 domain; Region: SH3_3; cl02551 315730000512 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 315730000513 dimer interface [polypeptide binding]; other site 315730000514 ssDNA binding site [nucleotide binding]; other site 315730000515 tetramer (dimer of dimers) interface [polypeptide binding]; other site 315730000516 Phage lysis protein, holin; Region: Phage_holin; cl04675 315730000517 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 315730000518 Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may...; Region: SynN; cl00143 315730000519 3D domain; Region: 3D; cl01439 315730000520 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730000521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730000522 active site 315730000523 phosphorylation site [posttranslational modification] 315730000524 intermolecular recognition site; other site 315730000525 dimerization interface [polypeptide binding]; other site 315730000526 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730000527 DNA binding site [nucleotide binding] 315730000528 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 315730000529 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730000530 ATP binding site [chemical binding]; other site 315730000531 Mg2+ binding site [ion binding]; other site 315730000532 G-X-G motif; other site 315730000533 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730000534 dimer interface [polypeptide binding]; other site 315730000535 phosphorylation site [posttranslational modification] 315730000536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730000537 ATP binding site [chemical binding]; other site 315730000538 Mg2+ binding site [ion binding]; other site 315730000539 G-X-G motif; other site 315730000540 Predicted P-loop ATPase and inactivated derivatives [General function prediction only]; Region: COG5545 315730000541 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 315730000542 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 315730000543 active site 315730000544 catalytic residues [active] 315730000545 Phage protein (N4 Gp49/phage Sf6 gene 66) family; Region: Phage_gp49_66; cl10351 315730000546 replicative DNA helicase; Validated; Region: PRK07773 315730000547 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 315730000548 thioester formation/cholesterol transfer; other site 315730000549 protein-splicing catalytic site; other site 315730000550 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 315730000551 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 315730000552 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 315730000553 Catalytic site; other site 315730000554 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 315730000555 N-acetyl-D-glucosamine binding site [chemical binding]; other site 315730000556 catalytic residue [active] 315730000557 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 315730000558 amidase catalytic site [active] 315730000559 Zn binding residues [ion binding]; other site 315730000560 substrate binding site [chemical binding]; other site 315730000561 Peptidase family M23; Region: Peptidase_M23; pfam01551 315730000562 Baseplate J-like protein; Region: Baseplate_J; cl01294 315730000563 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 315730000564 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 315730000565 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 315730000566 nudix motif; other site 315730000567 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 315730000568 Int/Topo IB signature motif; other site 315730000569 active site 315730000570 DNA binding site [nucleotide binding] 315730000571 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 315730000572 Haemolysin XhlA; Region: XhlA; pfam10779 315730000573 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 315730000574 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 315730000575 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 315730000576 Predicted transcriptional regulator [Transcription]; Region: COG2378 315730000577 YolD-like protein; Region: YolD; pfam08863 315730000578 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315730000579 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 315730000580 DNA binding residues [nucleotide binding] 315730000581 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 315730000582 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 315730000583 peptide binding site [polypeptide binding]; other site 315730000584 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 315730000585 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 315730000586 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 315730000587 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 315730000588 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 315730000589 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 315730000590 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 315730000591 P-loop; other site 315730000592 Magnesium ion binding site [ion binding]; other site 315730000593 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 315730000594 Magnesium ion binding site [ion binding]; other site 315730000595 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 315730000596 multiple promoter invertase; Provisional; Region: mpi; PRK13413 315730000597 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 315730000598 catalytic residues [active] 315730000599 catalytic nucleophile [active] 315730000600 Presynaptic Site I dimer interface [polypeptide binding]; other site 315730000601 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 315730000602 Synaptic Flat tetramer interface [polypeptide binding]; other site 315730000603 Synaptic Site I dimer interface [polypeptide binding]; other site 315730000604 DNA binding site [nucleotide binding] 315730000605 Helix-turn-helix domains; Region: HTH; cl00088 315730000606 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730000607 putative DNA binding site [nucleotide binding]; other site 315730000608 dimerization interface [polypeptide binding]; other site 315730000609 putative Zn2+ binding site [ion binding]; other site 315730000610 H+ Antiporter protein; Region: 2A0121; TIGR00900 315730000611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730000612 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 315730000613 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 315730000614 Toxin ToxN, type III toxin-antitoxin system; Region: ToxN_toxin; pfam13958 315730000615 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 315730000616 DNA topoisomerase III; Provisional; Region: PRK07726 315730000617 active site 315730000618 putative interdomain interaction site [polypeptide binding]; other site 315730000619 putative metal-binding site [ion binding]; other site 315730000620 putative nucleotide binding site [chemical binding]; other site 315730000621 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 315730000622 domain I; other site 315730000623 DNA binding groove [nucleotide binding] 315730000624 phosphate binding site [ion binding]; other site 315730000625 domain II; other site 315730000626 domain III; other site 315730000627 nucleotide binding site [chemical binding]; other site 315730000628 catalytic site [active] 315730000629 domain IV; other site 315730000630 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 315730000631 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 315730000632 CAAX protease self-immunity; Region: Abi; cl00558 315730000633 Protein of unknown function (DUF3956); Region: DUF3956; pfam13104 315730000634 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 315730000635 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 315730000636 putative metal binding site; other site 315730000637 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730000638 binding surface 315730000639 TPR motif; other site 315730000640 Initiator Replication protein; Region: Rep_3; cl03080 315730000641 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 315730000642 active site 315730000643 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 315730000644 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730000645 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 315730000646 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730000647 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 315730000648 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730000649 NAD(P) binding site [chemical binding]; other site 315730000650 active site 315730000651 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 315730000652 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315730000653 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 315730000654 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315730000655 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 315730000656 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 315730000657 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 315730000658 active site 315730000659 ATP binding site [chemical binding]; other site 315730000660 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315730000661 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 315730000662 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 315730000663 deoxynucleoside monophosphate kinase; Provisional; Region: 1; PHA02575 315730000664 3D domain; Region: 3D; cl01439 315730000665 thymidine kinase; Provisional; Region: PRK04296 315730000666 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730000667 non-specific DNA binding site [nucleotide binding]; other site 315730000668 salt bridge; other site 315730000669 sequence-specific DNA binding site [nucleotide binding]; other site 315730000670 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 315730000671 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 315730000672 Nucleoside recognition; Region: Gate; cl00486 315730000673 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 315730000674 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 315730000675 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 315730000676 Substrate-binding site [chemical binding]; other site 315730000677 Substrate specificity [chemical binding]; other site 315730000678 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 315730000679 active site 315730000680 putative DNA-binding cleft [nucleotide binding]; other site 315730000681 dimer interface [polypeptide binding]; other site 315730000682 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 315730000683 active site 315730000684 substrate binding site [chemical binding]; other site 315730000685 catalytic site [active] 315730000686 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 315730000687 catalytic site [active] 315730000688 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 315730000689 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 315730000690 active site 315730000691 catalytic site [active] 315730000692 substrate binding site [chemical binding]; other site 315730000693 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730000694 non-specific DNA binding site [nucleotide binding]; other site 315730000695 salt bridge; other site 315730000696 sequence-specific DNA binding site [nucleotide binding]; other site 315730000697 hypothetical protein; Provisional; Region: PRK08624 315730000698 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 315730000699 Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305 315730000700 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730000701 Walker A motif; other site 315730000702 ATP binding site [chemical binding]; other site 315730000703 Walker B motif; other site 315730000704 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 315730000705 Ligand Binding Site [chemical binding]; other site 315730000706 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730000707 Helix-turn-helix domains; Region: HTH; cl00088 315730000708 plasmid segregation protein ParM; Provisional; Region: PRK13917 315730000709 Helix-turn-helix domains; Region: HTH; cl00088 315730000710 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 315730000711 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 315730000712 active site 315730000713 metal binding site [ion binding]; metal-binding site 315730000714 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 315730000715 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 315730000716 Histone H1-like nucleoprotein HC2; Region: HC2; pfam07382 315730000717 Phage-related protein [Function unknown]; Region: COG4722; cl15832 315730000718 Phage tail protein; Region: Sipho_tail; pfam05709 315730000719 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 315730000720 MAEBL; Provisional; Region: PTZ00121 315730000721 Fungal protein of unknown function (DUF1742); Region: DUF1742; pfam08432 315730000722 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 315730000723 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 315730000724 TIR domain; Region: TIR_2; cl15770 315730000725 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 315730000726 Helix-turn-helix of insertion element transposase; Region: HTH_Tnp_1_2; pfam13022 315730000727 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 315730000728 DNA binding site [nucleotide binding] 315730000729 Int/Topo IB signature motif; other site 315730000730 active site 315730000731 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 315730000732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 315730000733 cofactor binding site; other site 315730000734 DNA binding site [nucleotide binding] 315730000735 substrate interaction site [chemical binding]; other site 315730000736 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 315730000737 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 315730000738 GIY-YIG motif/motif A; other site 315730000739 active site 315730000740 catalytic site [active] 315730000741 putative DNA binding site [nucleotide binding]; other site 315730000742 metal binding site [ion binding]; metal-binding site 315730000743 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 315730000744 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 315730000745 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 315730000746 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 315730000747 active site 315730000748 catalytic site [active] 315730000749 Excalibur calcium-binding domain; Region: Excalibur; cl05460 315730000750 Domain of unknown function (DUF955); Region: DUF955; cl01076 315730000751 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 315730000752 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 315730000753 BRO family, N-terminal domain; Region: Bro-N; cl10591 315730000754 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 315730000755 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730000756 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 315730000757 Walker A motif; other site 315730000758 ATP binding site [chemical binding]; other site 315730000759 Walker B motif; other site 315730000760 arginine finger; other site 315730000761 Recombination protein U; Region: RecU; cl01314 315730000762 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 315730000763 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 315730000764 Phage Terminase; Region: Terminase_1; pfam03354 315730000765 Phage-related protein [Function unknown]; Region: COG4695; cl01923 315730000766 Phage portal protein; Region: Phage_portal; pfam04860 315730000767 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 315730000768 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 315730000769 Phage capsid family; Region: Phage_capsid; pfam05065 315730000770 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 315730000771 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 315730000772 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 315730000773 Phage-related minor tail protein [Function unknown]; Region: COG5280 315730000774 Phage-related protein [Function unknown]; Region: COG5412 315730000775 Phage-related protein [Function unknown]; Region: COG4722; cl15832 315730000776 Phage-related protein [Function unknown]; Region: COG4722; cl15832 315730000777 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 315730000778 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 315730000779 Holin family; Region: Phage_holin_4; cl01989 315730000780 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 315730000781 amidase catalytic site [active] 315730000782 Zn binding residues [ion binding]; other site 315730000783 substrate binding site [chemical binding]; other site 315730000784 Bacterial SH3 domain; Region: SH3_3; cl02551 315730000785 Bacterial SH3 domain; Region: SH3_3; cl02551 315730000786 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 315730000787 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730000788 Replication-relaxation; Region: Replic_Relax; pfam13814 315730000789 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 315730000790 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315730000791 DNA binding residues [nucleotide binding] 315730000792 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730000793 non-specific DNA binding site [nucleotide binding]; other site 315730000794 salt bridge; other site 315730000795 sequence-specific DNA binding site [nucleotide binding]; other site 315730000796 Protein of unknown function DUF91; Region: DUF91; cl00709 315730000797 Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654 315730000798 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 315730000799 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 315730000800 P-loop; other site 315730000801 Magnesium ion binding site [ion binding]; other site 315730000802 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 315730000803 Magnesium ion binding site [ion binding]; other site 315730000804 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 315730000805 DnaA N-terminal domain; Region: DnaA_N; pfam11638 315730000806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730000807 Walker A motif; other site 315730000808 ATP binding site [chemical binding]; other site 315730000809 Walker B motif; other site 315730000810 arginine finger; other site 315730000811 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 315730000812 DnaA box-binding interface [nucleotide binding]; other site 315730000813 DNA polymerase III subunit beta; Validated; Region: PRK05643 315730000814 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 315730000815 putative DNA binding surface [nucleotide binding]; other site 315730000816 dimer interface [polypeptide binding]; other site 315730000817 beta-clamp/clamp loader binding surface; other site 315730000818 beta-clamp/translesion DNA polymerase binding surface; other site 315730000819 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 315730000820 recombination protein F; Reviewed; Region: recF; PRK00064 315730000821 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 315730000822 Walker A/P-loop; other site 315730000823 ATP binding site [chemical binding]; other site 315730000824 Q-loop/lid; other site 315730000825 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730000826 ABC transporter signature motif; other site 315730000827 Walker B; other site 315730000828 D-loop; other site 315730000829 H-loop/switch region; other site 315730000830 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 315730000831 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730000832 Mg2+ binding site [ion binding]; other site 315730000833 G-X-G motif; other site 315730000834 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 315730000835 anchoring element; other site 315730000836 dimer interface [polypeptide binding]; other site 315730000837 ATP binding site [chemical binding]; other site 315730000838 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 315730000839 active site 315730000840 putative metal-binding site [ion binding]; other site 315730000841 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 315730000842 DNA gyrase subunit A; Validated; Region: PRK05560 315730000843 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 315730000844 CAP-like domain; other site 315730000845 active site 315730000846 primary dimer interface [polypeptide binding]; other site 315730000847 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315730000848 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315730000849 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315730000850 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315730000851 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315730000852 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315730000853 YaaC-like Protein; Region: YaaC; pfam14175 315730000854 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 315730000855 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 315730000856 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 315730000857 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 315730000858 active site 315730000859 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 315730000860 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730000861 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 315730000862 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 315730000863 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 315730000864 active site 315730000865 multimer interface [polypeptide binding]; other site 315730000866 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 315730000867 predicted active site [active] 315730000868 catalytic triad [active] 315730000869 seryl-tRNA synthetase; Provisional; Region: PRK05431 315730000870 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 315730000871 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 315730000872 dimer interface [polypeptide binding]; other site 315730000873 active site 315730000874 motif 1; other site 315730000875 motif 2; other site 315730000876 motif 3; other site 315730000877 Domain of unknown function (DUF3797); Region: DUF3797; pfam12677 315730000878 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 315730000879 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 315730000880 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 315730000881 Substrate-binding site [chemical binding]; other site 315730000882 Substrate specificity [chemical binding]; other site 315730000883 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 315730000884 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 315730000885 Substrate-binding site [chemical binding]; other site 315730000886 Substrate specificity [chemical binding]; other site 315730000887 Isochorismatase family; Region: Isochorismatase; pfam00857 315730000888 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 315730000889 catalytic triad [active] 315730000890 conserved cis-peptide bond; other site 315730000891 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 315730000892 nucleoside/Zn binding site; other site 315730000893 dimer interface [polypeptide binding]; other site 315730000894 catalytic motif [active] 315730000895 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 315730000896 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730000897 Walker A motif; other site 315730000898 ATP binding site [chemical binding]; other site 315730000899 Walker B motif; other site 315730000900 arginine finger; other site 315730000901 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 315730000902 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 315730000903 recombination protein RecR; Reviewed; Region: recR; PRK00076 315730000904 RecR protein; Region: RecR; pfam02132 315730000905 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 315730000906 putative active site [active] 315730000907 putative metal-binding site [ion binding]; other site 315730000908 tetramer interface [polypeptide binding]; other site 315730000909 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 315730000910 SigmaK-factor processing regulatory protein BofA; Region: BofA; cl06466 315730000911 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 315730000912 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 315730000913 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 315730000914 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 315730000915 catalytic residue [active] 315730000916 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 315730000917 thymidylate kinase; Validated; Region: tmk; PRK00698 315730000918 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 315730000919 TMP-binding site; other site 315730000920 ATP-binding site [chemical binding]; other site 315730000921 DNA polymerase III subunit delta'; Validated; Region: PRK08058 315730000922 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730000923 PSP1 C-terminal conserved region; Region: PSP1; cl00770 315730000924 TSC-22/dip/bun family; Region: TSC22; cl01853 315730000925 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 315730000926 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730000927 S-adenosylmethionine binding site [chemical binding]; other site 315730000928 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 315730000929 GIY-YIG motif/motif A; other site 315730000930 putative active site [active] 315730000931 putative metal binding site [ion binding]; other site 315730000932 Predicted methyltransferases [General function prediction only]; Region: COG0313 315730000933 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 315730000934 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 315730000935 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 315730000936 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 315730000937 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 315730000938 active site 315730000939 HIGH motif; other site 315730000940 KMSKS motif; other site 315730000941 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 315730000942 tRNA binding surface [nucleotide binding]; other site 315730000943 anticodon binding site; other site 315730000944 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 315730000945 dimer interface [polypeptide binding]; other site 315730000946 putative tRNA-binding site [nucleotide binding]; other site 315730000947 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 315730000948 active site 315730000949 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 315730000950 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 315730000951 putative active site [active] 315730000952 putative metal binding site [ion binding]; other site 315730000953 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 315730000954 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730000955 YabG peptidase U57; Region: Peptidase_U57; cl05250 315730000956 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 315730000957 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 315730000958 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 315730000959 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 315730000960 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 315730000961 pur operon repressor; Provisional; Region: PRK09213 315730000962 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 315730000963 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315730000964 active site 315730000965 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 315730000966 homotrimer interaction site [polypeptide binding]; other site 315730000967 putative active site [active] 315730000968 SpoVG; Region: SpoVG; cl00915 315730000969 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 315730000970 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 315730000971 Substrate binding site; other site 315730000972 Mg++ binding site; other site 315730000973 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 315730000974 active site 315730000975 substrate binding site [chemical binding]; other site 315730000976 CoA binding site [chemical binding]; other site 315730000977 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 315730000978 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 315730000979 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315730000980 active site 315730000981 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 315730000982 putative active site [active] 315730000983 catalytic residue [active] 315730000984 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 315730000985 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 315730000986 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 315730000987 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315730000988 ATP binding site [chemical binding]; other site 315730000989 putative Mg++ binding site [ion binding]; other site 315730000990 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315730000991 nucleotide binding region [chemical binding]; other site 315730000992 ATP-binding site [chemical binding]; other site 315730000993 TRCF domain; Region: TRCF; cl04088 315730000994 stage V sporulation protein T; Region: spore_V_T; TIGR02851 315730000995 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 315730000996 stage V sporulation protein B; Region: spore_V_B; TIGR02900 315730000997 MatE; Region: MatE; cl10513 315730000998 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 315730000999 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 315730001000 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 315730001001 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315730001002 RNA binding surface [nucleotide binding]; other site 315730001003 YabP family; Region: YabP; cl06766 315730001004 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 315730001005 Septum formation initiator; Region: DivIC; cl11433 315730001006 hypothetical protein; Provisional; Region: PRK08582 315730001007 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 315730001008 RNA binding site [nucleotide binding]; other site 315730001009 stage II sporulation protein E; Region: spore_II_E; TIGR02865 315730001010 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 315730001011 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 315730001012 Ligand Binding Site [chemical binding]; other site 315730001013 TilS substrate binding domain; Region: TilS; pfam09179 315730001014 B3/4 domain; Region: B3_4; cl11458 315730001015 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315730001016 active site 315730001017 FtsH Extracellular; Region: FtsH_ext; pfam06480 315730001018 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 315730001019 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730001020 Walker A motif; other site 315730001021 ATP binding site [chemical binding]; other site 315730001022 Walker B motif; other site 315730001023 arginine finger; other site 315730001024 Peptidase family M41; Region: Peptidase_M41; pfam01434 315730001025 Type III pantothenate kinase; Region: Pan_kinase; cl09130 315730001026 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 315730001027 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 315730001028 dimerization interface [polypeptide binding]; other site 315730001029 domain crossover interface; other site 315730001030 redox-dependent activation switch; other site 315730001031 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 315730001032 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 315730001033 dimer interface [polypeptide binding]; other site 315730001034 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730001035 catalytic residue [active] 315730001036 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 315730001037 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 315730001038 chorismate binding enzyme; Region: Chorismate_bind; cl10555 315730001039 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 315730001040 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 315730001041 glutamine binding [chemical binding]; other site 315730001042 catalytic triad [active] 315730001043 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 315730001044 homodimer interface [polypeptide binding]; other site 315730001045 substrate-cofactor binding pocket; other site 315730001046 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730001047 catalytic residue [active] 315730001048 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 315730001049 dihydropteroate synthase; Region: DHPS; TIGR01496 315730001050 substrate binding pocket [chemical binding]; other site 315730001051 dimer interface [polypeptide binding]; other site 315730001052 inhibitor binding site; inhibition site 315730001053 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 315730001054 homooctamer interface [polypeptide binding]; other site 315730001055 active site 315730001056 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 315730001057 catalytic center binding site [active] 315730001058 ATP binding site [chemical binding]; other site 315730001059 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730001060 non-specific DNA binding site [nucleotide binding]; other site 315730001061 salt bridge; other site 315730001062 sequence-specific DNA binding site [nucleotide binding]; other site 315730001063 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 315730001064 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 315730001065 FMN binding site [chemical binding]; other site 315730001066 active site 315730001067 catalytic residues [active] 315730001068 substrate binding site [chemical binding]; other site 315730001069 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 315730001070 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 315730001071 dimer interface [polypeptide binding]; other site 315730001072 putative anticodon binding site; other site 315730001073 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 315730001074 motif 1; other site 315730001075 active site 315730001076 motif 2; other site 315730001077 motif 3; other site 315730001078 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 315730001079 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 315730001080 UvrB/uvrC motif; Region: UVR; pfam02151 315730001081 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 315730001082 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 315730001083 ADP binding site [chemical binding]; other site 315730001084 phosphagen binding site; other site 315730001085 substrate specificity loop; other site 315730001086 Clp protease ATP binding subunit; Region: clpC; CHL00095 315730001087 Clp amino terminal domain; Region: Clp_N; pfam02861 315730001088 Clp amino terminal domain; Region: Clp_N; pfam02861 315730001089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730001090 Walker A motif; other site 315730001091 ATP binding site [chemical binding]; other site 315730001092 Walker B motif; other site 315730001093 arginine finger; other site 315730001094 UvrB/uvrC motif; Region: UVR; pfam02151 315730001095 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730001096 Walker A motif; other site 315730001097 ATP binding site [chemical binding]; other site 315730001098 Walker B motif; other site 315730001099 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 315730001100 DNA repair protein RadA; Provisional; Region: PRK11823 315730001101 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 315730001102 Walker A motif/ATP binding site; other site 315730001103 ATP binding site [chemical binding]; other site 315730001104 Walker B motif; other site 315730001105 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 315730001106 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 315730001107 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 315730001108 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 315730001109 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 315730001110 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 315730001111 putative active site [active] 315730001112 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 315730001113 substrate binding site; other site 315730001114 dimer interface; other site 315730001115 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 315730001116 homotrimer interaction site [polypeptide binding]; other site 315730001117 zinc binding site [ion binding]; other site 315730001118 CDP-binding sites; other site 315730001119 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 315730001120 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 315730001121 HIGH motif; other site 315730001122 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 315730001123 active site 315730001124 KMSKS motif; other site 315730001125 serine O-acetyltransferase; Region: cysE; TIGR01172 315730001126 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 315730001127 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 315730001128 trimer interface [polypeptide binding]; other site 315730001129 active site 315730001130 substrate binding site [chemical binding]; other site 315730001131 CoA binding site [chemical binding]; other site 315730001132 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 315730001133 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 315730001134 active site 315730001135 HIGH motif; other site 315730001136 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 315730001137 KMSKS motif; other site 315730001138 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 315730001139 tRNA binding surface [nucleotide binding]; other site 315730001140 anticodon binding site; other site 315730001141 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 315730001142 active site 315730001143 metal binding site [ion binding]; metal-binding site 315730001144 dimerization interface [polypeptide binding]; other site 315730001145 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 315730001146 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 315730001147 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 315730001148 YacP-like NYN domain; Region: NYN_YacP; cl01491 315730001149 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 315730001150 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730001151 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 315730001152 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 315730001153 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 315730001154 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 315730001155 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 315730001156 putative homodimer interface [polypeptide binding]; other site 315730001157 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 315730001158 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 315730001159 23S rRNA interface [nucleotide binding]; other site 315730001160 L7/L12 interface [polypeptide binding]; other site 315730001161 putative thiostrepton binding site; other site 315730001162 L25 interface [polypeptide binding]; other site 315730001163 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 315730001164 mRNA/rRNA interface [nucleotide binding]; other site 315730001165 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 315730001166 23S rRNA interface [nucleotide binding]; other site 315730001167 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 315730001168 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 315730001169 core dimer interface [polypeptide binding]; other site 315730001170 peripheral dimer interface [polypeptide binding]; other site 315730001171 L10 interface [polypeptide binding]; other site 315730001172 L11 interface [polypeptide binding]; other site 315730001173 putative EF-Tu interaction site [polypeptide binding]; other site 315730001174 putative EF-G interaction site [polypeptide binding]; other site 315730001175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730001176 S-adenosylmethionine binding site [chemical binding]; other site 315730001177 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 315730001178 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 315730001179 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 315730001180 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 315730001181 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 315730001182 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 315730001183 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 315730001184 RPB10 interaction site [polypeptide binding]; other site 315730001185 RPB1 interaction site [polypeptide binding]; other site 315730001186 RPB11 interaction site [polypeptide binding]; other site 315730001187 RPB3 interaction site [polypeptide binding]; other site 315730001188 RPB12 interaction site [polypeptide binding]; other site 315730001189 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 315730001190 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 315730001191 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 315730001192 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 315730001193 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 315730001194 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 315730001195 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 315730001196 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 315730001197 G-loop; other site 315730001198 DNA binding site [nucleotide binding] 315730001199 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 315730001200 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 315730001201 S17 interaction site [polypeptide binding]; other site 315730001202 S8 interaction site; other site 315730001203 16S rRNA interaction site [nucleotide binding]; other site 315730001204 streptomycin interaction site [chemical binding]; other site 315730001205 23S rRNA interaction site [nucleotide binding]; other site 315730001206 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 315730001207 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 315730001208 elongation factor G; Reviewed; Region: PRK00007 315730001209 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 315730001210 G1 box; other site 315730001211 putative GEF interaction site [polypeptide binding]; other site 315730001212 GTP/Mg2+ binding site [chemical binding]; other site 315730001213 Switch I region; other site 315730001214 G2 box; other site 315730001215 G3 box; other site 315730001216 Switch II region; other site 315730001217 G4 box; other site 315730001218 G5 box; other site 315730001219 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 315730001220 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 315730001221 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 315730001222 elongation factor Tu; Reviewed; Region: PRK00049 315730001223 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 315730001224 G1 box; other site 315730001225 GEF interaction site [polypeptide binding]; other site 315730001226 GTP/Mg2+ binding site [chemical binding]; other site 315730001227 Switch I region; other site 315730001228 G2 box; other site 315730001229 G3 box; other site 315730001230 Switch II region; other site 315730001231 G4 box; other site 315730001232 G5 box; other site 315730001233 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 315730001234 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 315730001235 Antibiotic Binding Site [chemical binding]; other site 315730001236 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 315730001237 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 315730001238 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 315730001239 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 315730001240 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 315730001241 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 315730001242 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 315730001243 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 315730001244 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 315730001245 putative translocon binding site; other site 315730001246 protein-rRNA interface [nucleotide binding]; other site 315730001247 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 315730001248 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 315730001249 G-X-X-G motif; other site 315730001250 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 315730001251 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 315730001252 23S rRNA interface [nucleotide binding]; other site 315730001253 5S rRNA interface [nucleotide binding]; other site 315730001254 putative antibiotic binding site [chemical binding]; other site 315730001255 L25 interface [polypeptide binding]; other site 315730001256 L27 interface [polypeptide binding]; other site 315730001257 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 315730001258 23S rRNA interface [nucleotide binding]; other site 315730001259 putative translocon interaction site; other site 315730001260 signal recognition particle (SRP54) interaction site; other site 315730001261 L23 interface [polypeptide binding]; other site 315730001262 trigger factor interaction site; other site 315730001263 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 315730001264 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 315730001265 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 315730001266 KOW motif; Region: KOW; cl00354 315730001267 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 315730001268 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 315730001269 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 315730001270 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 315730001271 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 315730001272 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 315730001273 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 315730001274 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 315730001275 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 315730001276 5S rRNA interface [nucleotide binding]; other site 315730001277 L27 interface [polypeptide binding]; other site 315730001278 23S rRNA interface [nucleotide binding]; other site 315730001279 L5 interface [polypeptide binding]; other site 315730001280 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 315730001281 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 315730001282 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 315730001283 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 315730001284 23S rRNA binding site [nucleotide binding]; other site 315730001285 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 315730001286 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 315730001287 SecY translocase; Region: SecY; pfam00344 315730001288 adenylate kinase; Reviewed; Region: adk; PRK00279 315730001289 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 315730001290 AMP-binding site [chemical binding]; other site 315730001291 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 315730001292 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 315730001293 active site 315730001294 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 315730001295 rRNA binding site [nucleotide binding]; other site 315730001296 predicted 30S ribosome binding site; other site 315730001297 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 315730001298 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 315730001299 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 315730001300 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 315730001301 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 315730001302 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 315730001303 alphaNTD - beta interaction site [polypeptide binding]; other site 315730001304 alphaNTD homodimer interface [polypeptide binding]; other site 315730001305 alphaNTD - beta' interaction site [polypeptide binding]; other site 315730001306 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 315730001307 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 315730001308 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 315730001309 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 315730001310 Walker A/P-loop; other site 315730001311 ATP binding site [chemical binding]; other site 315730001312 Q-loop/lid; other site 315730001313 ABC transporter signature motif; other site 315730001314 Walker B; other site 315730001315 D-loop; other site 315730001316 H-loop/switch region; other site 315730001317 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 315730001318 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 315730001319 Walker A/P-loop; other site 315730001320 ATP binding site [chemical binding]; other site 315730001321 Q-loop/lid; other site 315730001322 ABC transporter signature motif; other site 315730001323 Walker B; other site 315730001324 D-loop; other site 315730001325 H-loop/switch region; other site 315730001326 Cobalt transport protein; Region: CbiQ; cl00463 315730001327 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 315730001328 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 315730001329 dimerization interface 3.5A [polypeptide binding]; other site 315730001330 active site 315730001331 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 315730001332 23S rRNA interface [nucleotide binding]; other site 315730001333 L3 interface [polypeptide binding]; other site 315730001334 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 315730001335 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 315730001336 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 315730001337 active site 315730001338 metal binding site [ion binding]; metal-binding site 315730001339 Domain of unknown function DUF59; Region: DUF59; cl00941 315730001340 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 315730001341 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 315730001342 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 315730001343 NodB motif; other site 315730001344 putative active site [active] 315730001345 putative catalytic site [active] 315730001346 Glycerate kinase family; Region: Gly_kinase; cl00841 315730001347 Arginase family; Region: Arginase; cl00306 315730001348 Uncharacterized conserved protein [Function unknown]; Region: COG1624 315730001349 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 315730001350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 315730001351 YbbR-like protein; Region: YbbR; pfam07949 315730001352 YbbR-like protein; Region: YbbR; pfam07949 315730001353 YbbR-like protein; Region: YbbR; pfam07949 315730001354 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 315730001355 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 315730001356 active site 315730001357 substrate binding site [chemical binding]; other site 315730001358 metal binding site [ion binding]; metal-binding site 315730001359 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 315730001360 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 315730001361 glutaminase active site [active] 315730001362 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 315730001363 dimer interface [polypeptide binding]; other site 315730001364 active site 315730001365 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 315730001366 dimer interface [polypeptide binding]; other site 315730001367 active site 315730001368 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 315730001369 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315730001370 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 315730001371 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 315730001372 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 315730001373 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730001374 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730001375 DNA binding residues [nucleotide binding] 315730001376 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 315730001377 classical (c) SDRs; Region: SDR_c; cd05233 315730001378 NAD(P) binding site [chemical binding]; other site 315730001379 active site 315730001380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730001381 dimer interface [polypeptide binding]; other site 315730001382 conserved gate region; other site 315730001383 ABC-ATPase subunit interface; other site 315730001384 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 315730001385 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 315730001386 Walker A/P-loop; other site 315730001387 ATP binding site [chemical binding]; other site 315730001388 Q-loop/lid; other site 315730001389 ABC transporter signature motif; other site 315730001390 Walker B; other site 315730001391 D-loop; other site 315730001392 H-loop/switch region; other site 315730001393 NIL domain; Region: NIL; cl09633 315730001394 NMT1-like family; Region: NMT1_2; cl15260 315730001395 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 315730001396 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 315730001397 putative NAD(P) binding site [chemical binding]; other site 315730001398 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 315730001399 FAD binding domain; Region: FAD_binding_4; pfam01565 315730001400 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 315730001401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730001402 putative substrate translocation pore; other site 315730001403 Domain of unknown function (DUF3981); Region: DUF3981; pfam13139 315730001404 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 315730001405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730001406 putative substrate translocation pore; other site 315730001407 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 315730001408 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 315730001409 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 315730001410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730001411 dimer interface [polypeptide binding]; other site 315730001412 conserved gate region; other site 315730001413 putative PBP binding loops; other site 315730001414 ABC-ATPase subunit interface; other site 315730001415 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 315730001416 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 315730001417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730001418 dimer interface [polypeptide binding]; other site 315730001419 conserved gate region; other site 315730001420 putative PBP binding loops; other site 315730001421 ABC-ATPase subunit interface; other site 315730001422 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 315730001423 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 315730001424 Walker A/P-loop; other site 315730001425 ATP binding site [chemical binding]; other site 315730001426 Q-loop/lid; other site 315730001427 ABC transporter signature motif; other site 315730001428 Walker B; other site 315730001429 D-loop; other site 315730001430 H-loop/switch region; other site 315730001431 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 315730001432 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 315730001433 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 315730001434 Walker A/P-loop; other site 315730001435 ATP binding site [chemical binding]; other site 315730001436 Q-loop/lid; other site 315730001437 ABC transporter signature motif; other site 315730001438 Walker B; other site 315730001439 D-loop; other site 315730001440 H-loop/switch region; other site 315730001441 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 315730001442 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 315730001443 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 315730001444 peptide binding site [polypeptide binding]; other site 315730001445 YusW-like protein; Region: YusW; pfam14039 315730001446 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315730001447 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 315730001448 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315730001449 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 315730001450 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 315730001451 peptide binding site [polypeptide binding]; other site 315730001452 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 315730001453 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 315730001454 peptide binding site [polypeptide binding]; other site 315730001455 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 315730001456 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 315730001457 active site 315730001458 catalytic tetrad [active] 315730001459 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730001460 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 315730001461 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 315730001462 Sugar transport protein; Region: Sugar_transport; pfam06800 315730001463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730001464 dimer interface [polypeptide binding]; other site 315730001465 conserved gate region; other site 315730001466 putative PBP binding loops; other site 315730001467 ABC-ATPase subunit interface; other site 315730001468 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 315730001469 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 315730001470 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 315730001471 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 315730001472 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315730001473 Helix-turn-helix domains; Region: HTH; cl00088 315730001474 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 315730001475 putative dimerization interface [polypeptide binding]; other site 315730001476 EamA-like transporter family; Region: EamA; cl01037 315730001477 YrzO-like protein; Region: YrzO; pfam14142 315730001478 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 315730001479 putative acyl-acceptor binding pocket; other site 315730001480 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 315730001481 Transcriptional regulators [Transcription]; Region: PurR; COG1609 315730001482 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315730001483 DNA binding site [nucleotide binding] 315730001484 domain linker motif; other site 315730001485 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 315730001486 putative ligand binding site [chemical binding]; other site 315730001487 putative dimerization interface [polypeptide binding]; other site 315730001488 Uncharacterized conserved protein [Function unknown]; Region: COG1284 315730001489 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315730001490 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315730001491 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 315730001492 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 315730001493 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 315730001494 active site 315730001495 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 315730001496 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 315730001497 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 315730001498 lysozyme catalytic site [active] 315730001499 catalytic residue [active] 315730001500 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 315730001501 nucleotide binding site/active site [active] 315730001502 HIT family signature motif; other site 315730001503 catalytic residue [active] 315730001504 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 315730001505 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 315730001506 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 315730001507 ABC transporter; Region: ABC_tran_2; pfam12848 315730001508 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 315730001509 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 315730001510 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 315730001511 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 315730001512 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 315730001513 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 315730001514 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730001515 dimer interface [polypeptide binding]; other site 315730001516 conserved gate region; other site 315730001517 putative PBP binding loops; other site 315730001518 ABC-ATPase subunit interface; other site 315730001519 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 315730001520 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 315730001521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730001522 dimer interface [polypeptide binding]; other site 315730001523 conserved gate region; other site 315730001524 putative PBP binding loops; other site 315730001525 ABC-ATPase subunit interface; other site 315730001526 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 315730001527 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 315730001528 Walker A/P-loop; other site 315730001529 ATP binding site [chemical binding]; other site 315730001530 Q-loop/lid; other site 315730001531 ABC transporter signature motif; other site 315730001532 Walker B; other site 315730001533 D-loop; other site 315730001534 H-loop/switch region; other site 315730001535 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 315730001536 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 315730001537 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 315730001538 Walker A/P-loop; other site 315730001539 ATP binding site [chemical binding]; other site 315730001540 Q-loop/lid; other site 315730001541 ABC transporter signature motif; other site 315730001542 Walker B; other site 315730001543 D-loop; other site 315730001544 H-loop/switch region; other site 315730001545 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 315730001546 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730001547 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 315730001548 active site 315730001549 motif I; other site 315730001550 motif II; other site 315730001551 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730001552 motif II; other site 315730001553 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 315730001554 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 315730001555 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 315730001556 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 315730001557 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 315730001558 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 315730001559 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 315730001560 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 315730001561 dimer interface [polypeptide binding]; other site 315730001562 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 315730001563 active site 315730001564 Fe binding site [ion binding]; other site 315730001565 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 315730001566 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 315730001567 Cupin domain; Region: Cupin_2; cl09118 315730001568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730001569 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730001570 putative substrate translocation pore; other site 315730001571 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 315730001572 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 315730001573 ATP-grasp domain; Region: ATP-grasp_4; cl03087 315730001574 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 315730001575 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 315730001576 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 315730001577 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 315730001578 helicase 45; Provisional; Region: PTZ00424 315730001579 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 315730001580 ATP binding site [chemical binding]; other site 315730001581 Mg++ binding site [ion binding]; other site 315730001582 motif III; other site 315730001583 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315730001584 nucleotide binding region [chemical binding]; other site 315730001585 ATP-binding site [chemical binding]; other site 315730001586 UV-endonuclease UvdE; Region: UvdE; cl10036 315730001587 Rhomboid family; Region: Rhomboid; cl11446 315730001588 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 315730001589 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 315730001590 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 315730001591 alanine racemase; Reviewed; Region: alr; PRK00053 315730001592 active site 315730001593 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 315730001594 dimer interface [polypeptide binding]; other site 315730001595 substrate binding site [chemical binding]; other site 315730001596 catalytic residues [active] 315730001597 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 315730001598 PemK-like protein; Region: PemK; cl00995 315730001599 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 315730001600 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 315730001601 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 315730001602 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 315730001603 RNA binding site [nucleotide binding]; other site 315730001604 SprT homologues; Region: SprT; cl01182 315730001605 hypothetical protein; Provisional; Region: PRK04351 315730001606 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 315730001607 Glycoprotease family; Region: Peptidase_M22; pfam00814 315730001608 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 315730001609 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 315730001610 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730001611 Coenzyme A binding pocket [chemical binding]; other site 315730001612 UGMP family protein; Validated; Region: PRK09604 315730001613 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 315730001614 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 315730001615 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 315730001616 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 315730001617 ABC transporter; Region: ABC_tran_2; pfam12848 315730001618 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 315730001619 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 315730001620 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 315730001621 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730001622 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 315730001623 CAAX protease self-immunity; Region: Abi; cl00558 315730001624 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 315730001625 oligomerisation interface [polypeptide binding]; other site 315730001626 mobile loop; other site 315730001627 roof hairpin; other site 315730001628 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 315730001629 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 315730001630 ring oligomerisation interface [polypeptide binding]; other site 315730001631 ATP/Mg binding site [chemical binding]; other site 315730001632 stacking interactions; other site 315730001633 hinge regions; other site 315730001634 GMP synthase; Reviewed; Region: guaA; PRK00074 315730001635 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 315730001636 AMP/PPi binding site [chemical binding]; other site 315730001637 candidate oxyanion hole; other site 315730001638 catalytic triad [active] 315730001639 potential glutamine specificity residues [chemical binding]; other site 315730001640 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 315730001641 ATP Binding subdomain [chemical binding]; other site 315730001642 Ligand Binding sites [chemical binding]; other site 315730001643 Dimerization subdomain; other site 315730001644 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 315730001645 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730001646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730001647 active site 315730001648 phosphorylation site [posttranslational modification] 315730001649 intermolecular recognition site; other site 315730001650 dimerization interface [polypeptide binding]; other site 315730001651 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730001652 DNA binding site [nucleotide binding] 315730001653 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730001654 dimerization interface [polypeptide binding]; other site 315730001655 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730001656 dimer interface [polypeptide binding]; other site 315730001657 phosphorylation site [posttranslational modification] 315730001658 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730001659 ATP binding site [chemical binding]; other site 315730001660 Mg2+ binding site [ion binding]; other site 315730001661 G-X-G motif; other site 315730001662 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315730001663 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 315730001664 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315730001665 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 315730001666 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 315730001667 catalytic residues [active] 315730001668 Rhamnan synthesis protein F; Region: RgpF; cl01529 315730001669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730001670 S-adenosylmethionine binding site [chemical binding]; other site 315730001671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730001672 S-adenosylmethionine binding site [chemical binding]; other site 315730001673 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 315730001674 UDP-glucose 4-epimerase (G4E), subgroup 5, extended (e) SDRs; Region: UDP_G4E_5_SDR_e; cd05264 315730001675 putative NAD(P) binding site [chemical binding]; other site 315730001676 active site 315730001677 putative substrate binding site [chemical binding]; other site 315730001678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730001679 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315730001680 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 315730001681 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 315730001682 active site 315730001683 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 315730001684 Bacitracin resistance protein BacA; Region: BacA; cl00858 315730001685 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 315730001686 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315730001687 Walker A/P-loop; other site 315730001688 ATP binding site [chemical binding]; other site 315730001689 Q-loop/lid; other site 315730001690 ABC transporter signature motif; other site 315730001691 Walker B; other site 315730001692 D-loop; other site 315730001693 H-loop/switch region; other site 315730001694 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730001695 dimer interface [polypeptide binding]; other site 315730001696 phosphorylation site [posttranslational modification] 315730001697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730001698 ATP binding site [chemical binding]; other site 315730001699 Mg2+ binding site [ion binding]; other site 315730001700 G-X-G motif; other site 315730001701 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730001702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730001703 active site 315730001704 phosphorylation site [posttranslational modification] 315730001705 intermolecular recognition site; other site 315730001706 dimerization interface [polypeptide binding]; other site 315730001707 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730001708 DNA binding site [nucleotide binding] 315730001709 EamA-like transporter family; Region: EamA; cl01037 315730001710 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 315730001711 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 315730001712 AIR carboxylase; Region: AIRC; cl00310 315730001713 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730001714 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 315730001715 ATP-grasp domain; Region: ATP-grasp_4; cl03087 315730001716 adenylosuccinate lyase; Provisional; Region: PRK07492 315730001717 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 315730001718 tetramer interface [polypeptide binding]; other site 315730001719 active site 315730001720 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 315730001721 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 315730001722 ATP binding site [chemical binding]; other site 315730001723 active site 315730001724 substrate binding site [chemical binding]; other site 315730001725 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 315730001726 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 315730001727 putative active site [active] 315730001728 catalytic triad [active] 315730001729 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 315730001730 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 315730001731 dimerization interface [polypeptide binding]; other site 315730001732 ATP binding site [chemical binding]; other site 315730001733 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 315730001734 dimerization interface [polypeptide binding]; other site 315730001735 ATP binding site [chemical binding]; other site 315730001736 amidophosphoribosyltransferase; Provisional; Region: PRK06781 315730001737 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 315730001738 active site 315730001739 tetramer interface [polypeptide binding]; other site 315730001740 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315730001741 active site 315730001742 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 315730001743 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 315730001744 dimerization interface [polypeptide binding]; other site 315730001745 putative ATP binding site [chemical binding]; other site 315730001746 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 315730001747 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 315730001748 active site 315730001749 substrate binding site [chemical binding]; other site 315730001750 cosubstrate binding site; other site 315730001751 catalytic site [active] 315730001752 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 315730001753 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 315730001754 purine monophosphate binding site [chemical binding]; other site 315730001755 dimer interface [polypeptide binding]; other site 315730001756 putative catalytic residues [active] 315730001757 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 315730001758 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 315730001759 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 315730001760 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 315730001761 ATP-grasp domain; Region: ATP-grasp_4; cl03087 315730001762 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 315730001763 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 315730001764 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 315730001765 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 315730001766 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 315730001767 substrate binding site [chemical binding]; other site 315730001768 putative active site [active] 315730001769 dimer interface [polypeptide binding]; other site 315730001770 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 315730001771 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730001772 Family description; Region: UvrD_C_2; cl15862 315730001773 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 315730001774 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 315730001775 nucleotide binding pocket [chemical binding]; other site 315730001776 K-X-D-G motif; other site 315730001777 catalytic site [active] 315730001778 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 315730001779 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 315730001780 Dimer interface [polypeptide binding]; other site 315730001781 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 315730001782 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 315730001783 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 315730001784 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 315730001785 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 315730001786 Glutamate binding site [chemical binding]; other site 315730001787 homodimer interface [polypeptide binding]; other site 315730001788 NAD binding site [chemical binding]; other site 315730001789 catalytic residues [active] 315730001790 Isochorismatase family; Region: Isochorismatase; pfam00857 315730001791 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 315730001792 catalytic triad [active] 315730001793 conserved cis-peptide bond; other site 315730001794 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 315730001795 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 315730001796 Walker A/P-loop; other site 315730001797 ATP binding site [chemical binding]; other site 315730001798 Q-loop/lid; other site 315730001799 ABC transporter signature motif; other site 315730001800 Walker B; other site 315730001801 D-loop; other site 315730001802 H-loop/switch region; other site 315730001803 NIL domain; Region: NIL; cl09633 315730001804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730001805 dimer interface [polypeptide binding]; other site 315730001806 conserved gate region; other site 315730001807 ABC-ATPase subunit interface; other site 315730001808 NMT1-like family; Region: NMT1_2; cl15260 315730001809 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 315730001810 Protein of unknown function (DUF3926); Region: DUF3926; pfam13080 315730001811 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 315730001812 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 315730001813 P loop; other site 315730001814 Nucleotide binding site [chemical binding]; other site 315730001815 DTAP/Switch II; other site 315730001816 Switch I; other site 315730001817 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 315730001818 putative dimer interface [polypeptide binding]; other site 315730001819 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315730001820 Helix-turn-helix domains; Region: HTH; cl00088 315730001821 Helix-turn-helix domains; Region: HTH; cl00088 315730001822 yiaA/B two helix domain; Region: YiaAB; cl01759 315730001823 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 315730001824 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 315730001825 Amidase; Region: Amidase; cl11426 315730001826 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 315730001827 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 315730001828 GatB domain; Region: GatB_Yqey; cl11497 315730001829 putative lipid kinase; Reviewed; Region: PRK13337 315730001830 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 315730001831 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 315730001832 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730001833 motif II; other site 315730001834 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 315730001835 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315730001836 inhibitor-cofactor binding pocket; inhibition site 315730001837 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730001838 catalytic residue [active] 315730001839 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 315730001840 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 315730001841 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730001842 Walker A motif; other site 315730001843 ATP binding site [chemical binding]; other site 315730001844 Walker B motif; other site 315730001845 arginine finger; other site 315730001846 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 315730001847 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 315730001848 tetramerization interface [polypeptide binding]; other site 315730001849 NAD(P) binding site [chemical binding]; other site 315730001850 catalytic residues [active] 315730001851 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 315730001852 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 315730001853 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 315730001854 putative active site [active] 315730001855 putative metal binding site [ion binding]; other site 315730001856 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 315730001857 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 315730001858 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 315730001859 TRAM domain; Region: TRAM; cl01282 315730001860 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 315730001861 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730001862 S-adenosylmethionine binding site [chemical binding]; other site 315730001863 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 315730001864 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 315730001865 FMN binding site [chemical binding]; other site 315730001866 active site 315730001867 catalytic residues [active] 315730001868 substrate binding site [chemical binding]; other site 315730001869 GAF domain; Region: GAF_2; pfam13185 315730001870 GAF domain; Region: GAF; cl15785 315730001871 GAF domain; Region: GAF; cl15785 315730001872 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 315730001873 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730001874 dimer interface [polypeptide binding]; other site 315730001875 phosphorylation site [posttranslational modification] 315730001876 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730001877 ATP binding site [chemical binding]; other site 315730001878 Mg2+ binding site [ion binding]; other site 315730001879 G-X-G motif; other site 315730001880 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 315730001881 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 315730001882 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 315730001883 Protein of unknown function DUF45; Region: DUF45; cl00636 315730001884 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 315730001885 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 315730001886 active site 315730001887 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 315730001888 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 315730001889 amidohydrolase; Region: amidohydrolases; TIGR01891 315730001890 metal binding site [ion binding]; metal-binding site 315730001891 putative dimer interface [polypeptide binding]; other site 315730001892 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730001893 S-adenosylmethionine binding site [chemical binding]; other site 315730001894 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 315730001895 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 315730001896 catalytic residue [active] 315730001897 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 315730001898 catalytic residues [active] 315730001899 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315730001900 peroxiredoxin; Region: AhpC; TIGR03137 315730001901 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 315730001902 dimer interface [polypeptide binding]; other site 315730001903 decamer (pentamer of dimers) interface [polypeptide binding]; other site 315730001904 catalytic triad [active] 315730001905 peroxidatic and resolving cysteines [active] 315730001906 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315730001907 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 315730001908 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 315730001909 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 315730001910 intersubunit interface [polypeptide binding]; other site 315730001911 active site 315730001912 Zn2+ binding site [ion binding]; other site 315730001913 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315730001914 dimer interface [polypeptide binding]; other site 315730001915 putative PBP binding regions; other site 315730001916 ABC-ATPase subunit interface; other site 315730001917 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315730001918 ABC-ATPase subunit interface; other site 315730001919 dimer interface [polypeptide binding]; other site 315730001920 putative PBP binding regions; other site 315730001921 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 315730001922 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 315730001923 putative ligand binding residues [chemical binding]; other site 315730001924 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 315730001925 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730001926 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 315730001927 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 315730001928 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 315730001929 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730001930 dimer interface [polypeptide binding]; other site 315730001931 phosphorylation site [posttranslational modification] 315730001932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730001933 ATP binding site [chemical binding]; other site 315730001934 Mg2+ binding site [ion binding]; other site 315730001935 G-X-G motif; other site 315730001936 Putative cyclase; Region: Cyclase; cl00814 315730001937 hypothetical protein; Provisional; Region: PRK06851 315730001938 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730001939 Walker A motif; other site 315730001940 ATP binding site [chemical binding]; other site 315730001941 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730001942 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 315730001943 benzoate transport; Region: 2A0115; TIGR00895 315730001944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730001945 putative substrate translocation pore; other site 315730001946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730001947 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730001948 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 315730001949 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 315730001950 [2Fe-2S] cluster binding site [ion binding]; other site 315730001951 Fatty acid desaturase; Region: FA_desaturase; pfam00487 315730001952 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 315730001953 putative di-iron ligands [ion binding]; other site 315730001954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730001955 dimer interface [polypeptide binding]; other site 315730001956 conserved gate region; other site 315730001957 putative PBP binding loops; other site 315730001958 ABC-ATPase subunit interface; other site 315730001959 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 315730001960 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 315730001961 substrate binding pocket [chemical binding]; other site 315730001962 membrane-bound complex binding site; other site 315730001963 hinge residues; other site 315730001964 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 315730001965 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 315730001966 Walker A/P-loop; other site 315730001967 ATP binding site [chemical binding]; other site 315730001968 Q-loop/lid; other site 315730001969 ABC transporter signature motif; other site 315730001970 Walker B; other site 315730001971 D-loop; other site 315730001972 H-loop/switch region; other site 315730001973 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730001974 dimerization interface [polypeptide binding]; other site 315730001975 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315730001976 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315730001977 dimer interface [polypeptide binding]; other site 315730001978 putative CheW interface [polypeptide binding]; other site 315730001979 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 315730001980 FAD binding domain; Region: FAD_binding_4; pfam01565 315730001981 Berberine and berberine like; Region: BBE; pfam08031 315730001982 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 315730001983 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 315730001984 Ca binding site [ion binding]; other site 315730001985 active site 315730001986 catalytic site [active] 315730001987 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 315730001988 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 315730001989 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 315730001990 active site turn [active] 315730001991 phosphorylation site [posttranslational modification] 315730001992 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 315730001993 putative catalytic site [active] 315730001994 putative metal binding site [ion binding]; other site 315730001995 putative phosphate binding site [ion binding]; other site 315730001996 Predicted membrane protein [Function unknown]; Region: COG1511 315730001997 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 315730001998 Predicted membrane protein [Function unknown]; Region: COG1511 315730001999 ABC-2 type transporter; Region: ABC2_membrane; cl11417 315730002000 DNA topoisomerase III; Provisional; Region: PRK07726 315730002001 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 315730002002 active site 315730002003 putative interdomain interaction site [polypeptide binding]; other site 315730002004 putative metal-binding site [ion binding]; other site 315730002005 putative nucleotide binding site [chemical binding]; other site 315730002006 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 315730002007 domain I; other site 315730002008 DNA binding groove [nucleotide binding] 315730002009 phosphate binding site [ion binding]; other site 315730002010 domain II; other site 315730002011 domain III; other site 315730002012 nucleotide binding site [chemical binding]; other site 315730002013 catalytic site [active] 315730002014 domain IV; other site 315730002015 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 315730002016 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 315730002017 substrate binding site [chemical binding]; other site 315730002018 multimerization interface [polypeptide binding]; other site 315730002019 ATP binding site [chemical binding]; other site 315730002020 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 315730002021 thiamine phosphate binding site [chemical binding]; other site 315730002022 active site 315730002023 pyrophosphate binding site [ion binding]; other site 315730002024 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 315730002025 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 315730002026 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315730002027 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315730002028 dimer interface [polypeptide binding]; other site 315730002029 putative CheW interface [polypeptide binding]; other site 315730002030 Domain of unknown function DUF77; Region: DUF77; cl00307 315730002031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730002032 dimer interface [polypeptide binding]; other site 315730002033 conserved gate region; other site 315730002034 putative PBP binding loops; other site 315730002035 ABC-ATPase subunit interface; other site 315730002036 NMT1/THI5 like; Region: NMT1; pfam09084 315730002037 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 315730002038 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 315730002039 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 315730002040 Walker A/P-loop; other site 315730002041 ATP binding site [chemical binding]; other site 315730002042 Q-loop/lid; other site 315730002043 ABC transporter signature motif; other site 315730002044 Walker B; other site 315730002045 D-loop; other site 315730002046 H-loop/switch region; other site 315730002047 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 315730002048 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730002049 Walker A/P-loop; other site 315730002050 ATP binding site [chemical binding]; other site 315730002051 Q-loop/lid; other site 315730002052 ABC transporter signature motif; other site 315730002053 Walker B; other site 315730002054 D-loop; other site 315730002055 H-loop/switch region; other site 315730002056 ABC transporter; Region: ABC_tran_2; pfam12848 315730002057 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 315730002058 Glyco_18 domain; Region: Glyco_18; smart00636 315730002059 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 315730002060 active site 315730002061 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 315730002062 Cellulose binding domain; Region: CBM_2; cl02709 315730002063 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 315730002064 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 315730002065 catalytic residues [active] 315730002066 Helix-turn-helix domains; Region: HTH; cl00088 315730002067 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 315730002068 H+ Antiporter protein; Region: 2A0121; TIGR00900 315730002069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730002070 putative substrate translocation pore; other site 315730002071 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730002072 non-specific DNA binding site [nucleotide binding]; other site 315730002073 salt bridge; other site 315730002074 sequence-specific DNA binding site [nucleotide binding]; other site 315730002075 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 315730002076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730002077 putative substrate translocation pore; other site 315730002078 Sulfatase; Region: Sulfatase; cl10460 315730002079 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 315730002080 YesK-like protein; Region: YesK; pfam14150 315730002081 prolyl-tRNA synthetase; Provisional; Region: PRK08661 315730002082 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_arch_euk; cd00778 315730002083 dimer interface [polypeptide binding]; other site 315730002084 motif 1; other site 315730002085 active site 315730002086 motif 2; other site 315730002087 motif 3; other site 315730002088 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 315730002089 anticodon binding site; other site 315730002090 zinc-binding site [ion binding]; other site 315730002091 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 315730002092 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 315730002093 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 315730002094 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 315730002095 putative metal binding site [ion binding]; other site 315730002096 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 315730002097 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 315730002098 putative metal binding site [ion binding]; other site 315730002099 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 315730002100 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 315730002101 putative metal binding site [ion binding]; other site 315730002102 Integral membrane protein TerC family; Region: TerC; cl10468 315730002103 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 315730002104 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 315730002105 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 315730002106 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 315730002107 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 315730002108 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 315730002109 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 315730002110 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 315730002111 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 315730002112 Low molecular weight phosphatase family; Region: LMWPc; cd00115 315730002113 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 315730002114 active site 315730002115 Domain of unknown function (DUF4075); Region: DUF4075; pfam13294 315730002116 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 315730002117 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 315730002118 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 315730002119 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 315730002120 EamA-like transporter family; Region: EamA; cl01037 315730002121 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 315730002122 EamA-like transporter family; Region: EamA; cl01037 315730002123 YhhN-like protein; Region: YhhN; cl01505 315730002124 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 315730002125 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 315730002126 Catalytic site [active] 315730002127 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 315730002128 EamA-like transporter family; Region: EamA; cl01037 315730002129 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 315730002130 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 315730002131 calcium/proton exchanger (cax); Region: cax; TIGR00378 315730002132 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 315730002133 YfkD-like protein; Region: YfkD; pfam14167 315730002134 Radical SAM superfamily; Region: Radical_SAM; pfam04055 315730002135 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315730002136 FeS/SAM binding site; other site 315730002137 YfkB-like domain; Region: YfkB; pfam08756 315730002138 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 315730002139 Fumarase C-terminus; Region: Fumerase_C; cl00795 315730002140 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 315730002141 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 315730002142 NodB motif; other site 315730002143 active site 315730002144 catalytic site [active] 315730002145 Cd binding site [ion binding]; other site 315730002146 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 315730002147 endonuclease III; Region: ENDO3c; smart00478 315730002148 minor groove reading motif; other site 315730002149 helix-hairpin-helix signature motif; other site 315730002150 substrate binding pocket [chemical binding]; other site 315730002151 active site 315730002152 TRAM domain; Region: TRAM; cl01282 315730002153 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 315730002154 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730002155 S-adenosylmethionine binding site [chemical binding]; other site 315730002156 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 315730002157 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 315730002158 dimerization interface 3.5A [polypeptide binding]; other site 315730002159 active site 315730002160 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 315730002161 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730002162 Walker A motif; other site 315730002163 ATP binding site [chemical binding]; other site 315730002164 Walker B motif; other site 315730002165 arginine finger; other site 315730002166 Helix-turn-helix domains; Region: HTH; cl00088 315730002167 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 315730002168 S-methylmethionine transporter; Provisional; Region: PRK11387 315730002169 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 315730002170 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 315730002171 metal binding site [ion binding]; metal-binding site 315730002172 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730002173 non-specific DNA binding site [nucleotide binding]; other site 315730002174 salt bridge; other site 315730002175 sequence-specific DNA binding site [nucleotide binding]; other site 315730002176 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 315730002177 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 315730002178 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 315730002179 Glutaminase; Region: Glutaminase; cl00907 315730002180 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 315730002181 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 315730002182 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 315730002183 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 315730002184 active site turn [active] 315730002185 phosphorylation site [posttranslational modification] 315730002186 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730002187 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 315730002188 active site 315730002189 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 315730002190 active site 315730002191 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 315730002192 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730002193 NAD(P) binding site [chemical binding]; other site 315730002194 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 315730002195 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730002196 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730002197 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 315730002198 NAD(P) binding site [chemical binding]; other site 315730002199 active site 315730002200 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 315730002201 active site 315730002202 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 315730002203 active site 315730002204 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 315730002205 Pyruvate formate lyase 1; Region: PFL1; cd01678 315730002206 coenzyme A binding site [chemical binding]; other site 315730002207 active site 315730002208 catalytic residues [active] 315730002209 glycine loop; other site 315730002210 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 315730002211 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315730002212 FeS/SAM binding site; other site 315730002213 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 315730002214 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 315730002215 YfhE-like protein; Region: YfhE; pfam14152 315730002216 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730002217 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 315730002218 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 315730002219 active site 315730002220 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 315730002221 TIGR01777 family protein; Region: yfcH 315730002222 putative NAD(P) binding site [chemical binding]; other site 315730002223 putative active site [active] 315730002224 RecX family; Region: RecX; cl00936 315730002225 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 315730002226 YpzG-like protein; Region: YpzG; pfam14139 315730002227 Small acid-soluble spore protein K family; Region: SspK; cl11509 315730002228 WVELL protein; Region: WVELL; pfam14043 315730002229 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 315730002230 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 315730002231 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 315730002232 minor groove reading motif; other site 315730002233 helix-hairpin-helix signature motif; other site 315730002234 substrate binding pocket [chemical binding]; other site 315730002235 active site 315730002236 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 315730002237 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 315730002238 DNA binding and oxoG recognition site [nucleotide binding] 315730002239 YgaB-like protein; Region: YgaB; pfam14182 315730002240 Protein of unknown function (DUF402); Region: DUF402; cl00979 315730002241 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 315730002242 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 315730002243 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 315730002244 Walker A/P-loop; other site 315730002245 ATP binding site [chemical binding]; other site 315730002246 Q-loop/lid; other site 315730002247 ABC transporter signature motif; other site 315730002248 Walker B; other site 315730002249 D-loop; other site 315730002250 H-loop/switch region; other site 315730002251 Predicted membrane protein [Function unknown]; Region: COG4129 315730002252 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 315730002253 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 315730002254 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 315730002255 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 315730002256 active site 315730002257 dimer interface [polypeptide binding]; other site 315730002258 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 315730002259 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 315730002260 active site 315730002261 FMN binding site [chemical binding]; other site 315730002262 substrate binding site [chemical binding]; other site 315730002263 3Fe-4S cluster binding site [ion binding]; other site 315730002264 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 315730002265 domain_subunit interface; other site 315730002266 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 315730002267 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315730002268 inhibitor-cofactor binding pocket; inhibition site 315730002269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730002270 catalytic residue [active] 315730002271 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 315730002272 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730002273 Walker A/P-loop; other site 315730002274 ATP binding site [chemical binding]; other site 315730002275 Q-loop/lid; other site 315730002276 ABC transporter signature motif; other site 315730002277 Walker B; other site 315730002278 D-loop; other site 315730002279 H-loop/switch region; other site 315730002280 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 315730002281 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 315730002282 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 315730002283 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 315730002284 Ion channel; Region: Ion_trans_2; cl11596 315730002285 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 315730002286 catalytic triad [active] 315730002287 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 315730002288 metal binding site 2 [ion binding]; metal-binding site 315730002289 putative DNA binding helix; other site 315730002290 metal binding site 1 [ion binding]; metal-binding site 315730002291 dimer interface [polypeptide binding]; other site 315730002292 structural Zn2+ binding site [ion binding]; other site 315730002293 Protein of unknown function (DUF2614); Region: DUF2614; cl07936 315730002294 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 315730002295 Transcriptional regulator; Region: Transcrip_reg; cl00361 315730002296 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 315730002297 nudix motif; other site 315730002298 Transglycosylase; Region: Transgly; cl07896 315730002299 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 315730002300 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 315730002301 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 315730002302 NlpC/P60 family; Region: NLPC_P60; cl11438 315730002303 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 315730002304 PAS fold; Region: PAS_4; pfam08448 315730002305 PAS fold; Region: PAS; pfam00989 315730002306 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315730002307 putative active site [active] 315730002308 heme pocket [chemical binding]; other site 315730002309 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 315730002310 metal binding site [ion binding]; metal-binding site 315730002311 active site 315730002312 I-site; other site 315730002313 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 315730002314 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 315730002315 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 315730002316 Uncharacterized conserved protein [Function unknown]; Region: COG2718 315730002317 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 315730002318 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 315730002319 heme-binding site [chemical binding]; other site 315730002320 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 315730002321 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 315730002322 Substrate binding site [chemical binding]; other site 315730002323 LRR adjacent; Region: LRR_adjacent; pfam08191 315730002324 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 315730002325 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 315730002326 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 315730002327 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 315730002328 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 315730002329 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 315730002330 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 315730002331 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 315730002332 Cache domain; Region: Cache_1; pfam02743 315730002333 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730002334 dimerization interface [polypeptide binding]; other site 315730002335 proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785 315730002336 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315730002337 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315730002338 dimer interface [polypeptide binding]; other site 315730002339 putative CheW interface [polypeptide binding]; other site 315730002340 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 315730002341 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 315730002342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730002343 ATP binding site [chemical binding]; other site 315730002344 Mg2+ binding site [ion binding]; other site 315730002345 G-X-G motif; other site 315730002346 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 315730002347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730002348 active site 315730002349 phosphorylation site [posttranslational modification] 315730002350 intermolecular recognition site; other site 315730002351 dimerization interface [polypeptide binding]; other site 315730002352 Citrate transporter; Region: CitMHS; pfam03600 315730002353 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 315730002354 transmembrane helices; other site 315730002355 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 315730002356 NosL; Region: NosL; cl01769 315730002357 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 315730002358 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 315730002359 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 315730002360 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 315730002361 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 315730002362 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 315730002363 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 315730002364 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730002365 Walker A/P-loop; other site 315730002366 ATP binding site [chemical binding]; other site 315730002367 Q-loop/lid; other site 315730002368 ABC transporter signature motif; other site 315730002369 Walker B; other site 315730002370 D-loop; other site 315730002371 H-loop/switch region; other site 315730002372 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 315730002373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730002374 dimer interface [polypeptide binding]; other site 315730002375 conserved gate region; other site 315730002376 putative PBP binding loops; other site 315730002377 ABC-ATPase subunit interface; other site 315730002378 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 315730002379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 315730002380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730002381 dimer interface [polypeptide binding]; other site 315730002382 conserved gate region; other site 315730002383 putative PBP binding loops; other site 315730002384 ABC-ATPase subunit interface; other site 315730002385 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 315730002386 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 315730002387 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 315730002388 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 315730002389 active site 315730002390 metal binding site [ion binding]; metal-binding site 315730002391 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730002392 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730002393 active site 315730002394 phosphorylation site [posttranslational modification] 315730002395 intermolecular recognition site; other site 315730002396 dimerization interface [polypeptide binding]; other site 315730002397 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730002398 DNA binding site [nucleotide binding] 315730002399 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730002400 dimer interface [polypeptide binding]; other site 315730002401 phosphorylation site [posttranslational modification] 315730002402 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730002403 ATP binding site [chemical binding]; other site 315730002404 Mg2+ binding site [ion binding]; other site 315730002405 G-X-G motif; other site 315730002406 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 315730002407 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 315730002408 putative active site [active] 315730002409 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 315730002410 Cache domain; Region: Cache_1; pfam02743 315730002411 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 315730002412 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730002413 dimerization interface [polypeptide binding]; other site 315730002414 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315730002415 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315730002416 dimer interface [polypeptide binding]; other site 315730002417 putative CheW interface [polypeptide binding]; other site 315730002418 sensory histidine kinase DcuS; Provisional; Region: PRK11086 315730002419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730002420 ATP binding site [chemical binding]; other site 315730002421 Mg2+ binding site [ion binding]; other site 315730002422 G-X-G motif; other site 315730002423 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 315730002424 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730002425 active site 315730002426 phosphorylation site [posttranslational modification] 315730002427 intermolecular recognition site; other site 315730002428 dimerization interface [polypeptide binding]; other site 315730002429 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 315730002430 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 315730002431 Malic enzyme, N-terminal domain; Region: malic; pfam00390 315730002432 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 315730002433 putative NAD(P) binding site [chemical binding]; other site 315730002434 EamA-like transporter family; Region: EamA; cl01037 315730002435 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 315730002436 EamA-like transporter family; Region: EamA; cl01037 315730002437 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 315730002438 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730002439 DNA-binding site [nucleotide binding]; DNA binding site 315730002440 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315730002441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730002442 homodimer interface [polypeptide binding]; other site 315730002443 catalytic residue [active] 315730002444 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 315730002445 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730002446 Coenzyme A binding pocket [chemical binding]; other site 315730002447 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 315730002448 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730002449 dimer interface [polypeptide binding]; other site 315730002450 phosphorylation site [posttranslational modification] 315730002451 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730002452 ATP binding site [chemical binding]; other site 315730002453 Mg2+ binding site [ion binding]; other site 315730002454 G-X-G motif; other site 315730002455 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730002456 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730002457 active site 315730002458 phosphorylation site [posttranslational modification] 315730002459 intermolecular recognition site; other site 315730002460 dimerization interface [polypeptide binding]; other site 315730002461 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730002462 DNA binding site [nucleotide binding] 315730002463 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 315730002464 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730002465 Coenzyme A binding pocket [chemical binding]; other site 315730002466 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 315730002467 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 315730002468 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 315730002469 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 315730002470 4Fe-4S binding domain; Region: Fer4; cl02805 315730002471 4Fe-4S binding domain; Region: Fer4; cl02805 315730002472 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 315730002473 [4Fe-4S] binding site [ion binding]; other site 315730002474 molybdopterin cofactor binding site; other site 315730002475 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 315730002476 molybdopterin cofactor binding site; other site 315730002477 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 315730002478 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 315730002479 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 315730002480 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 315730002481 putative active site [active] 315730002482 catalytic site [active] 315730002483 putative metal binding site [ion binding]; other site 315730002484 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 315730002485 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 315730002486 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730002487 amino acid transporter; Region: 2A0306; TIGR00909 315730002488 Spore germination protein; Region: Spore_permease; cl15802 315730002489 Spore germination protein; Region: Spore_permease; cl15802 315730002490 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730002491 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730002492 dimerization interface [polypeptide binding]; other site 315730002493 putative DNA binding site [nucleotide binding]; other site 315730002494 putative Zn2+ binding site [ion binding]; other site 315730002495 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 315730002496 metal-binding site [ion binding] 315730002497 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 315730002498 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 315730002499 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 315730002500 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 315730002501 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 315730002502 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 315730002503 active site 315730002504 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730002505 non-specific DNA binding site [nucleotide binding]; other site 315730002506 salt bridge; other site 315730002507 sequence-specific DNA binding site [nucleotide binding]; other site 315730002508 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315730002509 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 315730002510 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 315730002511 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 315730002512 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 315730002513 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 315730002514 active site 315730002515 Zn binding site [ion binding]; other site 315730002516 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 315730002517 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 315730002518 VanW like protein; Region: VanW; pfam04294 315730002519 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 315730002520 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 315730002521 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 315730002522 Nucleoside recognition; Region: Gate; cl00486 315730002523 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 315730002524 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 315730002525 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730002526 putative metal binding site [ion binding]; other site 315730002527 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 315730002528 Domain of unknown function DUF21; Region: DUF21; pfam01595 315730002529 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 315730002530 Transporter associated domain; Region: CorC_HlyC; cl08393 315730002531 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 315730002532 Aspartase; Region: Aspartase; cd01357 315730002533 active sites [active] 315730002534 tetramer interface [polypeptide binding]; other site 315730002535 glycolate transporter; Provisional; Region: PRK09695 315730002536 L-lactate permease; Region: Lactate_perm; cl00701 315730002537 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 315730002538 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 315730002539 catalytic residues [active] 315730002540 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730002541 putative DNA binding site [nucleotide binding]; other site 315730002542 putative Zn2+ binding site [ion binding]; other site 315730002543 Small acid-soluble spore protein H family; Region: SspH; cl06949 315730002544 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 315730002545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730002546 putative substrate translocation pore; other site 315730002547 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 315730002548 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 315730002549 siderophore binding site; other site 315730002550 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315730002551 ABC-ATPase subunit interface; other site 315730002552 dimer interface [polypeptide binding]; other site 315730002553 putative PBP binding regions; other site 315730002554 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 315730002555 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315730002556 ABC-ATPase subunit interface; other site 315730002557 dimer interface [polypeptide binding]; other site 315730002558 putative PBP binding regions; other site 315730002559 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 315730002560 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 315730002561 Walker A/P-loop; other site 315730002562 ATP binding site [chemical binding]; other site 315730002563 Q-loop/lid; other site 315730002564 ABC transporter signature motif; other site 315730002565 Walker B; other site 315730002566 D-loop; other site 315730002567 H-loop/switch region; other site 315730002568 Methyltransferase domain; Region: Methyltransf_31; pfam13847 315730002569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730002570 S-adenosylmethionine binding site [chemical binding]; other site 315730002571 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 315730002572 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 315730002573 substrate-cofactor binding pocket; other site 315730002574 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730002575 catalytic residue [active] 315730002576 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 315730002577 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 315730002578 NAD binding site [chemical binding]; other site 315730002579 homodimer interface [polypeptide binding]; other site 315730002580 active site 315730002581 putative substrate binding site [chemical binding]; other site 315730002582 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 315730002583 nudix motif; other site 315730002584 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 315730002585 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 315730002586 metal ion-dependent adhesion site (MIDAS); other site 315730002587 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730002588 Walker A motif; other site 315730002589 ATP binding site [chemical binding]; other site 315730002590 Walker B motif; other site 315730002591 arginine finger; other site 315730002592 cardiolipin synthetase; Reviewed; Region: PRK12452 315730002593 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 315730002594 putative active site [active] 315730002595 catalytic site [active] 315730002596 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 315730002597 putative active site [active] 315730002598 catalytic site [active] 315730002599 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315730002600 PAS domain; Region: PAS_9; pfam13426 315730002601 putative active site [active] 315730002602 heme pocket [chemical binding]; other site 315730002603 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 315730002604 metal binding site [ion binding]; metal-binding site 315730002605 active site 315730002606 I-site; other site 315730002607 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 315730002608 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 315730002609 Spore germination protein; Region: Spore_permease; cl15802 315730002610 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730002611 DNA-binding site [nucleotide binding]; DNA binding site 315730002612 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 315730002613 UTRA domain; Region: UTRA; cl01230 315730002614 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 315730002615 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 315730002616 active site turn [active] 315730002617 phosphorylation site [posttranslational modification] 315730002618 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 315730002619 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 315730002620 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 315730002621 Ca binding site [ion binding]; other site 315730002622 active site 315730002623 catalytic site [active] 315730002624 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 315730002625 Spore germination protein; Region: Spore_permease; cl15802 315730002626 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 315730002627 CAAX protease self-immunity; Region: Abi; cl00558 315730002628 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315730002629 active site 315730002630 ATP binding site [chemical binding]; other site 315730002631 substrate binding site [chemical binding]; other site 315730002632 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 315730002633 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 315730002634 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 315730002635 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 315730002636 Walker A/P-loop; other site 315730002637 ATP binding site [chemical binding]; other site 315730002638 Q-loop/lid; other site 315730002639 ABC transporter signature motif; other site 315730002640 Walker B; other site 315730002641 D-loop; other site 315730002642 H-loop/switch region; other site 315730002643 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 315730002644 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 315730002645 substrate binding pocket [chemical binding]; other site 315730002646 membrane-bound complex binding site; other site 315730002647 hinge residues; other site 315730002648 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 315730002649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730002650 dimer interface [polypeptide binding]; other site 315730002651 conserved gate region; other site 315730002652 putative PBP binding loops; other site 315730002653 ABC-ATPase subunit interface; other site 315730002654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730002655 dimer interface [polypeptide binding]; other site 315730002656 conserved gate region; other site 315730002657 putative PBP binding loops; other site 315730002658 ABC-ATPase subunit interface; other site 315730002659 S-methylmethionine transporter; Provisional; Region: PRK11387 315730002660 OsmC-like protein; Region: OsmC; cl00767 315730002661 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 315730002662 nucleotide binding site/active site [active] 315730002663 RNA polymerase sigma factor; Provisional; Region: PRK12542 315730002664 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730002665 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730002666 DNA binding residues [nucleotide binding] 315730002667 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 315730002668 Predicted transcriptional regulator [Transcription]; Region: COG2378 315730002669 Helix-turn-helix domains; Region: HTH; cl00088 315730002670 WYL domain; Region: WYL; cl14852 315730002671 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 315730002672 folate binding site [chemical binding]; other site 315730002673 NADP+ binding site [chemical binding]; other site 315730002674 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730002675 dimerization interface [polypeptide binding]; other site 315730002676 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730002677 dimer interface [polypeptide binding]; other site 315730002678 phosphorylation site [posttranslational modification] 315730002679 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730002680 ATP binding site [chemical binding]; other site 315730002681 Mg2+ binding site [ion binding]; other site 315730002682 G-X-G motif; other site 315730002683 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730002684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730002685 active site 315730002686 phosphorylation site [posttranslational modification] 315730002687 intermolecular recognition site; other site 315730002688 dimerization interface [polypeptide binding]; other site 315730002689 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730002690 DNA binding site [nucleotide binding] 315730002691 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 315730002692 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 315730002693 Sulfate transporter family; Region: Sulfate_transp; cl15842 315730002694 Sulfate transporter family; Region: Sulfate_transp; cl15842 315730002695 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 315730002696 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 315730002697 Ligand Binding Site [chemical binding]; other site 315730002698 Protein of unknown function (DUF4027); Region: DUF4027; pfam13219 315730002699 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 315730002700 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 315730002701 peptide binding site [polypeptide binding]; other site 315730002702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730002703 dimer interface [polypeptide binding]; other site 315730002704 conserved gate region; other site 315730002705 putative PBP binding loops; other site 315730002706 ABC-ATPase subunit interface; other site 315730002707 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 315730002708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730002709 dimer interface [polypeptide binding]; other site 315730002710 conserved gate region; other site 315730002711 putative PBP binding loops; other site 315730002712 ABC-ATPase subunit interface; other site 315730002713 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 315730002714 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 315730002715 Walker A/P-loop; other site 315730002716 ATP binding site [chemical binding]; other site 315730002717 Q-loop/lid; other site 315730002718 ABC transporter signature motif; other site 315730002719 Walker B; other site 315730002720 D-loop; other site 315730002721 H-loop/switch region; other site 315730002722 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 315730002723 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 315730002724 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 315730002725 Walker A/P-loop; other site 315730002726 ATP binding site [chemical binding]; other site 315730002727 Q-loop/lid; other site 315730002728 ABC transporter signature motif; other site 315730002729 Walker B; other site 315730002730 D-loop; other site 315730002731 H-loop/switch region; other site 315730002732 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 315730002733 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 315730002734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730002735 putative substrate translocation pore; other site 315730002736 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315730002737 Helix-turn-helix domains; Region: HTH; cl00088 315730002738 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 315730002739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730002740 putative substrate translocation pore; other site 315730002741 Transcriptional regulators [Transcription]; Region: PurR; COG1609 315730002742 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315730002743 DNA binding site [nucleotide binding] 315730002744 domain linker motif; other site 315730002745 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 315730002746 dimerization interface [polypeptide binding]; other site 315730002747 ligand binding site [chemical binding]; other site 315730002748 sodium binding site [ion binding]; other site 315730002749 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 315730002750 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 315730002751 substrate binding site [chemical binding]; other site 315730002752 dimer interface [polypeptide binding]; other site 315730002753 ATP binding site [chemical binding]; other site 315730002754 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 315730002755 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 315730002756 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 315730002757 Walker A/P-loop; other site 315730002758 ATP binding site [chemical binding]; other site 315730002759 Q-loop/lid; other site 315730002760 ABC transporter signature motif; other site 315730002761 Walker B; other site 315730002762 D-loop; other site 315730002763 H-loop/switch region; other site 315730002764 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 315730002765 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 315730002766 TM-ABC transporter signature motif; other site 315730002767 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 315730002768 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 315730002769 ligand binding site [chemical binding]; other site 315730002770 dimerization interface [polypeptide binding]; other site 315730002771 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 315730002772 active site 315730002773 intersubunit interactions; other site 315730002774 catalytic residue [active] 315730002775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 315730002776 Plant ATP synthase F0; Region: YMF19; cl07975 315730002777 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 315730002778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730002779 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730002780 putative substrate translocation pore; other site 315730002781 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 315730002782 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 315730002783 putative NAD(P) binding site [chemical binding]; other site 315730002784 catalytic Zn binding site [ion binding]; other site 315730002785 Ion channel; Region: Ion_trans_2; cl11596 315730002786 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; cl03005 315730002787 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 315730002788 putative catalytic site [active] 315730002789 metal binding site A [ion binding]; metal-binding site 315730002790 phosphate binding site [ion binding]; other site 315730002791 metal binding site C [ion binding]; metal-binding site 315730002792 metal binding site B [ion binding]; metal-binding site 315730002793 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 315730002794 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 315730002795 dimer interface [polypeptide binding]; other site 315730002796 active site 315730002797 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 315730002798 substrate binding site [chemical binding]; other site 315730002799 catalytic residue [active] 315730002800 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 315730002801 FAD binding domain; Region: FAD_binding_4; pfam01565 315730002802 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 315730002803 VanZ like family; Region: VanZ; cl01971 315730002804 RDD family; Region: RDD; cl00746 315730002805 Bacitracin resistance protein BacA; Region: BacA; cl00858 315730002806 IncA protein; Region: IncA; pfam04156 315730002807 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315730002808 dimer interface [polypeptide binding]; other site 315730002809 putative CheW interface [polypeptide binding]; other site 315730002810 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 315730002811 3D domain; Region: 3D; cl01439 315730002812 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730002813 non-specific DNA binding site [nucleotide binding]; other site 315730002814 salt bridge; other site 315730002815 sequence-specific DNA binding site [nucleotide binding]; other site 315730002816 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 315730002817 active site 315730002818 catalytic site [active] 315730002819 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 315730002820 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 315730002821 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 315730002822 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 315730002823 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 315730002824 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 315730002825 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 315730002826 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 315730002827 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 315730002828 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730002829 non-specific DNA binding site [nucleotide binding]; other site 315730002830 salt bridge; other site 315730002831 sequence-specific DNA binding site [nucleotide binding]; other site 315730002832 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730002833 Protein of unknown function (DUF4022); Region: DUF4022; pfam13214 315730002834 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 315730002835 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 315730002836 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 315730002837 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730002838 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 315730002839 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 315730002840 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 315730002841 Subunit I/III interface [polypeptide binding]; other site 315730002842 Subunit III/IV interface [polypeptide binding]; other site 315730002843 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 315730002844 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 315730002845 D-pathway; other site 315730002846 Putative ubiquinol binding site [chemical binding]; other site 315730002847 Low-spin heme (heme b) binding site [chemical binding]; other site 315730002848 Putative water exit pathway; other site 315730002849 Binuclear center (heme o3/CuB) [ion binding]; other site 315730002850 K-pathway; other site 315730002851 Putative proton exit pathway; other site 315730002852 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 315730002853 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 315730002854 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 315730002855 putative active site [active] 315730002856 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 315730002857 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 315730002858 metal binding site [ion binding]; metal-binding site 315730002859 dimer interface [polypeptide binding]; other site 315730002860 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 315730002861 Sodium:solute symporter family; Region: SSF; cl00456 315730002862 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 315730002863 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 315730002864 Spore germination protein; Region: Spore_permease; cl15802 315730002865 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 315730002866 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 315730002867 Nucleoside recognition; Region: Gate; cl00486 315730002868 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 315730002869 Nucleoside recognition; Region: Gate; cl00486 315730002870 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 315730002871 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 315730002872 G1 box; other site 315730002873 GTP/Mg2+ binding site [chemical binding]; other site 315730002874 Switch I region; other site 315730002875 G2 box; other site 315730002876 G3 box; other site 315730002877 Switch II region; other site 315730002878 G4 box; other site 315730002879 G5 box; other site 315730002880 FeoA domain; Region: FeoA; cl00838 315730002881 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 315730002882 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 315730002883 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 315730002884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730002885 dimer interface [polypeptide binding]; other site 315730002886 conserved gate region; other site 315730002887 putative PBP binding loops; other site 315730002888 ABC-ATPase subunit interface; other site 315730002889 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 315730002890 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730002891 dimer interface [polypeptide binding]; other site 315730002892 conserved gate region; other site 315730002893 putative PBP binding loops; other site 315730002894 ABC-ATPase subunit interface; other site 315730002895 FOG: CBS domain [General function prediction only]; Region: COG0517 315730002896 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 315730002897 Domain of unknown function (DUF3960); Region: DUF3960; pfam13142 315730002898 Protein of unknown function (DUF3965); Region: DUF3965; pfam13112 315730002899 Bacterial SH3 domain; Region: SH3_3; cl02551 315730002900 Bacterial SH3 domain; Region: SH3_3; cl02551 315730002901 Bacterial SH3 domain; Region: SH3_3; cl02551 315730002902 Peptidase family M23; Region: Peptidase_M23; pfam01551 315730002903 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 315730002904 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 315730002905 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 315730002906 Walker A/P-loop; other site 315730002907 ATP binding site [chemical binding]; other site 315730002908 Q-loop/lid; other site 315730002909 ABC transporter signature motif; other site 315730002910 Walker B; other site 315730002911 D-loop; other site 315730002912 H-loop/switch region; other site 315730002913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730002914 dimer interface [polypeptide binding]; other site 315730002915 conserved gate region; other site 315730002916 putative PBP binding loops; other site 315730002917 ABC-ATPase subunit interface; other site 315730002918 NMT1/THI5 like; Region: NMT1; pfam09084 315730002919 NMT1-like family; Region: NMT1_2; cl15260 315730002920 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 315730002921 thiamine phosphate binding site [chemical binding]; other site 315730002922 active site 315730002923 pyrophosphate binding site [ion binding]; other site 315730002924 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 315730002925 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730002926 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 315730002927 thiS-thiF/thiG interaction site; other site 315730002928 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 315730002929 ThiS interaction site; other site 315730002930 putative active site [active] 315730002931 tetramer interface [polypeptide binding]; other site 315730002932 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 315730002933 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 315730002934 ATP binding site [chemical binding]; other site 315730002935 substrate interface [chemical binding]; other site 315730002936 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 315730002937 dimer interface [polypeptide binding]; other site 315730002938 substrate binding site [chemical binding]; other site 315730002939 ATP binding site [chemical binding]; other site 315730002940 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 315730002941 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 315730002942 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 315730002943 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 315730002944 K+-transporting ATPase, c chain; Region: KdpC; cl00944 315730002945 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 315730002946 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 315730002947 Ligand Binding Site [chemical binding]; other site 315730002948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730002949 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730002950 putative substrate translocation pore; other site 315730002951 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315730002952 Helix-turn-helix domains; Region: HTH; cl00088 315730002953 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 315730002954 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 315730002955 active site 315730002956 nucleophile elbow; other site 315730002957 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 315730002958 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 315730002959 TM-ABC transporter signature motif; other site 315730002960 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 315730002961 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 315730002962 Walker A/P-loop; other site 315730002963 ATP binding site [chemical binding]; other site 315730002964 Q-loop/lid; other site 315730002965 ABC transporter signature motif; other site 315730002966 Walker B; other site 315730002967 D-loop; other site 315730002968 H-loop/switch region; other site 315730002969 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 315730002970 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 315730002971 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 315730002972 putative ligand binding site [chemical binding]; other site 315730002973 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 315730002974 short chain dehydrogenase; Provisional; Region: PRK06701 315730002975 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 315730002976 NAD binding site [chemical binding]; other site 315730002977 metal binding site [ion binding]; metal-binding site 315730002978 active site 315730002979 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 315730002980 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 315730002981 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 315730002982 catalytic residues [active] 315730002983 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 315730002984 YhdB-like protein; Region: YhdB; pfam14148 315730002985 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 315730002986 Spore germination protein; Region: Spore_permease; cl15802 315730002987 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 315730002988 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 315730002989 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 315730002990 putative FMN binding site [chemical binding]; other site 315730002991 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 315730002992 SpoVR like protein; Region: SpoVR; pfam04293 315730002993 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 315730002994 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 315730002995 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315730002996 Helix-turn-helix domains; Region: HTH; cl00088 315730002997 Protein of unknown function (DUF3238); Region: DUF3238; pfam11579 315730002998 Protein of unknown function (DUF3238); Region: DUF3238; pfam11579 315730002999 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 315730003000 putative homotetramer interface [polypeptide binding]; other site 315730003001 putative homodimer interface [polypeptide binding]; other site 315730003002 putative metal binding site [ion binding]; other site 315730003003 putative homodimer-homodimer interface [polypeptide binding]; other site 315730003004 putative allosteric switch controlling residues; other site 315730003005 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 315730003006 CPxP motif; other site 315730003007 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 315730003008 active site residue [active] 315730003009 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 315730003010 active site residue [active] 315730003011 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315730003012 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 315730003013 CPxP motif; other site 315730003014 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 315730003015 active site residue [active] 315730003016 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 315730003017 active site residue [active] 315730003018 DsrE/DsrF-like family; Region: DrsE; cl00672 315730003019 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 315730003020 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 315730003021 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 315730003022 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 315730003023 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 315730003024 NADP binding site [chemical binding]; other site 315730003025 dimer interface [polypeptide binding]; other site 315730003026 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 315730003027 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 315730003028 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 315730003029 PhoU domain; Region: PhoU; pfam01895 315730003030 PhoU domain; Region: PhoU; pfam01895 315730003031 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 315730003032 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 315730003033 putative NAD(P) binding site [chemical binding]; other site 315730003034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730003035 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730003036 putative substrate translocation pore; other site 315730003037 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 315730003038 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 315730003039 Helix-turn-helix domains; Region: HTH; cl00088 315730003040 Helix-turn-helix domains; Region: HTH; cl00088 315730003041 PRD domain; Region: PRD; cl15445 315730003042 PRD domain; Region: PRD; cl15445 315730003043 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 315730003044 P-loop; other site 315730003045 active site 315730003046 phosphorylation site [posttranslational modification] 315730003047 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 315730003048 active site 315730003049 phosphorylation site [posttranslational modification] 315730003050 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 315730003051 active site 315730003052 methionine cluster; other site 315730003053 phosphorylation site [posttranslational modification] 315730003054 metal binding site [ion binding]; metal-binding site 315730003055 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 315730003056 active site 315730003057 P-loop; other site 315730003058 phosphorylation site [posttranslational modification] 315730003059 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 315730003060 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 315730003061 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 315730003062 Bacterial SH3 domain; Region: SH3_3; cl02551 315730003063 Bacterial SH3 domain; Region: SH3_3; cl02551 315730003064 3D domain; Region: 3D; cl01439 315730003065 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 315730003066 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 315730003067 FtsX-like permease family; Region: FtsX; cl15850 315730003068 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730003069 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 315730003070 Walker A/P-loop; other site 315730003071 ATP binding site [chemical binding]; other site 315730003072 Q-loop/lid; other site 315730003073 ABC transporter signature motif; other site 315730003074 Walker B; other site 315730003075 D-loop; other site 315730003076 H-loop/switch region; other site 315730003077 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 315730003078 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 315730003079 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; cl02331 315730003080 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 315730003081 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 315730003082 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730003083 dimer interface [polypeptide binding]; other site 315730003084 conserved gate region; other site 315730003085 ABC-ATPase subunit interface; other site 315730003086 FtsX-like permease family; Region: FtsX; cl15850 315730003087 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 315730003088 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 315730003089 Uncharacterized conserved protein [Function unknown]; Region: COG1633 315730003090 dimanganese center [ion binding]; other site 315730003091 CotJB protein; Region: CotJB; pfam12652 315730003092 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 315730003093 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730003094 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 315730003095 active site 315730003096 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 315730003097 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 315730003098 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 315730003099 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 315730003100 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 315730003101 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 315730003102 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 315730003103 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 315730003104 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 315730003105 active site 315730003106 metal binding site [ion binding]; metal-binding site 315730003107 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 315730003108 Interdomain contacts; other site 315730003109 Cytokine receptor motif; other site 315730003110 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 315730003111 amino acid transporter; Region: 2A0306; TIGR00909 315730003112 Spore germination protein; Region: Spore_permease; cl15802 315730003113 Spore germination protein; Region: Spore_permease; cl15802 315730003114 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 315730003115 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 315730003116 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 315730003117 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 315730003118 putative active site [active] 315730003119 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 315730003120 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 315730003121 putative active site [active] 315730003122 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 315730003123 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 315730003124 active site turn [active] 315730003125 phosphorylation site [posttranslational modification] 315730003126 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 315730003127 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 315730003128 DoxX; Region: DoxX; cl00976 315730003129 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 315730003130 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315730003131 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 315730003132 hypothetical protein; Provisional; Region: PRK06770 315730003133 EamA-like transporter family; Region: EamA; cl01037 315730003134 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 315730003135 EamA-like transporter family; Region: EamA; cl01037 315730003136 Helix-turn-helix domains; Region: HTH; cl00088 315730003137 bifunctional argininosuccinate lyase/N-acetylglutamate synthase; Provisional; Region: PRK12308 315730003138 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730003139 Coenzyme A binding pocket [chemical binding]; other site 315730003140 short chain dehydrogenase; Provisional; Region: PRK06138 315730003141 classical (c) SDRs; Region: SDR_c; cd05233 315730003142 NAD(P) binding site [chemical binding]; other site 315730003143 active site 315730003144 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 315730003145 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315730003146 DNA binding residues [nucleotide binding] 315730003147 putative dimer interface [polypeptide binding]; other site 315730003148 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 315730003149 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 315730003150 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730003151 Helix-turn-helix domains; Region: HTH; cl00088 315730003152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730003153 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730003154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730003155 Helix-turn-helix domains; Region: HTH; cl00088 315730003156 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 315730003157 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 315730003158 intracellular protease, PfpI family; Region: PfpI; TIGR01382 315730003159 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 315730003160 proposed catalytic triad [active] 315730003161 conserved cys residue [active] 315730003162 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 315730003163 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 315730003164 Spore germination protein; Region: Spore_permease; cl15802 315730003165 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 315730003166 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 315730003167 tetrameric interface [polypeptide binding]; other site 315730003168 activator binding site; other site 315730003169 NADP binding site [chemical binding]; other site 315730003170 substrate binding site [chemical binding]; other site 315730003171 catalytic residues [active] 315730003172 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 315730003173 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 315730003174 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730003175 Walker A/P-loop; other site 315730003176 ATP binding site [chemical binding]; other site 315730003177 Q-loop/lid; other site 315730003178 ABC transporter signature motif; other site 315730003179 Walker B; other site 315730003180 D-loop; other site 315730003181 H-loop/switch region; other site 315730003182 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 315730003183 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 315730003184 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 315730003185 Walker A/P-loop; other site 315730003186 ATP binding site [chemical binding]; other site 315730003187 Q-loop/lid; other site 315730003188 ABC transporter signature motif; other site 315730003189 Walker B; other site 315730003190 D-loop; other site 315730003191 H-loop/switch region; other site 315730003192 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 315730003193 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 315730003194 substrate binding pocket [chemical binding]; other site 315730003195 membrane-bound complex binding site; other site 315730003196 hinge residues; other site 315730003197 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 315730003198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730003199 dimer interface [polypeptide binding]; other site 315730003200 conserved gate region; other site 315730003201 putative PBP binding loops; other site 315730003202 ABC-ATPase subunit interface; other site 315730003203 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 315730003204 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 315730003205 Walker A/P-loop; other site 315730003206 ATP binding site [chemical binding]; other site 315730003207 Q-loop/lid; other site 315730003208 ABC transporter signature motif; other site 315730003209 Walker B; other site 315730003210 D-loop; other site 315730003211 H-loop/switch region; other site 315730003212 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 315730003213 ATP-grasp domain; Region: ATP-grasp_4; cl03087 315730003214 ATP-grasp domain; Region: ATP-grasp_4; cl03087 315730003215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 315730003216 Protein of unknown function (DUF964); Region: DUF964; cl01483 315730003217 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 315730003218 acetolactate synthase; Reviewed; Region: PRK08617 315730003219 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 315730003220 PYR/PP interface [polypeptide binding]; other site 315730003221 dimer interface [polypeptide binding]; other site 315730003222 TPP binding site [chemical binding]; other site 315730003223 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 315730003224 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 315730003225 TPP-binding site [chemical binding]; other site 315730003226 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 315730003227 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 315730003228 putative metal binding site; other site 315730003229 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730003230 binding surface 315730003231 TPR motif; other site 315730003232 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 315730003233 binding surface 315730003234 TPR motif; other site 315730003235 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 315730003236 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 315730003237 Probable Catalytic site; other site 315730003238 metal-binding site 315730003239 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730003240 S-adenosylmethionine binding site [chemical binding]; other site 315730003241 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 315730003242 active site 315730003243 DNA binding site [nucleotide binding] 315730003244 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730003245 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 315730003246 active site 315730003247 motif I; other site 315730003248 motif II; other site 315730003249 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 315730003250 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315730003251 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315730003252 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315730003253 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315730003254 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315730003255 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315730003256 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315730003257 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315730003258 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315730003259 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 315730003260 amidase catalytic site [active] 315730003261 Zn binding residues [ion binding]; other site 315730003262 substrate binding site [chemical binding]; other site 315730003263 S-layer homology domain; Region: SLH; pfam00395 315730003264 S-layer homology domain; Region: SLH; pfam00395 315730003265 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 315730003266 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 315730003267 AMP-binding enzyme; Region: AMP-binding; cl15778 315730003268 AMP-binding enzyme; Region: AMP-binding; cl15778 315730003269 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 315730003270 Sulfate transporter family; Region: Sulfate_transp; cl15842 315730003271 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 315730003272 stage V sporulation protein B; Region: spore_V_B; TIGR02900 315730003273 MatE; Region: MatE; cl10513 315730003274 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 315730003275 S-layer homology domain; Region: SLH; pfam00395 315730003276 S-layer homology domain; Region: SLH; pfam00395 315730003277 S-layer homology domain; Region: SLH; pfam00395 315730003278 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 315730003279 enoyl-CoA hydratase; Provisional; Region: PRK07659 315730003280 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 315730003281 substrate binding site [chemical binding]; other site 315730003282 oxyanion hole (OAH) forming residues; other site 315730003283 trimer interface [polypeptide binding]; other site 315730003284 Uncharacterized conserved protein [Function unknown]; Region: COG4997 315730003285 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 315730003286 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 315730003287 putative oligomer interface [polypeptide binding]; other site 315730003288 putative active site [active] 315730003289 metal binding site [ion binding]; metal-binding site 315730003290 S-layer homology domain; Region: SLH; pfam00395 315730003291 S-layer homology domain; Region: SLH; pfam00395 315730003292 S-layer homology domain; Region: SLH; pfam00395 315730003293 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 315730003294 active site 315730003295 metal binding site [ion binding]; metal-binding site 315730003296 Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041 315730003297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730003298 S-adenosylmethionine binding site [chemical binding]; other site 315730003299 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 315730003300 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 315730003301 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 315730003302 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 315730003303 substrate binding pocket [chemical binding]; other site 315730003304 active site 315730003305 iron coordination sites [ion binding]; other site 315730003306 hydroxyglutarate oxidase; Provisional; Region: PRK11728 315730003307 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730003308 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 315730003309 putative metal binding site [ion binding]; other site 315730003310 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730003311 proline racemase; Provisional; Region: PRK13969 315730003312 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 315730003313 ornithine cyclodeaminase; Validated; Region: PRK08618 315730003314 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 315730003315 NAD(P) binding site [chemical binding]; other site 315730003316 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 315730003317 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 315730003318 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 315730003319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730003320 dimer interface [polypeptide binding]; other site 315730003321 conserved gate region; other site 315730003322 putative PBP binding loops; other site 315730003323 ABC-ATPase subunit interface; other site 315730003324 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 315730003325 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 315730003326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730003327 dimer interface [polypeptide binding]; other site 315730003328 conserved gate region; other site 315730003329 putative PBP binding loops; other site 315730003330 ABC-ATPase subunit interface; other site 315730003331 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 315730003332 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 315730003333 Walker A/P-loop; other site 315730003334 ATP binding site [chemical binding]; other site 315730003335 Q-loop/lid; other site 315730003336 ABC transporter signature motif; other site 315730003337 Walker B; other site 315730003338 D-loop; other site 315730003339 H-loop/switch region; other site 315730003340 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 315730003341 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 315730003342 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 315730003343 Walker A/P-loop; other site 315730003344 ATP binding site [chemical binding]; other site 315730003345 Q-loop/lid; other site 315730003346 ABC transporter signature motif; other site 315730003347 Walker B; other site 315730003348 D-loop; other site 315730003349 H-loop/switch region; other site 315730003350 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 315730003351 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730003352 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 315730003353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730003354 putative substrate translocation pore; other site 315730003355 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 315730003356 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 315730003357 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730003358 ATP binding site [chemical binding]; other site 315730003359 Mg2+ binding site [ion binding]; other site 315730003360 G-X-G motif; other site 315730003361 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 315730003362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730003363 active site 315730003364 phosphorylation site [posttranslational modification] 315730003365 intermolecular recognition site; other site 315730003366 dimerization interface [polypeptide binding]; other site 315730003367 NMT1-like family; Region: NMT1_2; cl15260 315730003368 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730003369 non-specific DNA binding site [nucleotide binding]; other site 315730003370 salt bridge; other site 315730003371 sequence-specific DNA binding site [nucleotide binding]; other site 315730003372 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 315730003373 Int/Topo IB signature motif; other site 315730003374 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 315730003375 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 315730003376 cofactor binding site; other site 315730003377 DNA binding site [nucleotide binding] 315730003378 substrate interaction site [chemical binding]; other site 315730003379 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730003380 LlaJI restriction endonuclease; Region: RE_LlaJI; pfam09563 315730003381 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 315730003382 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 315730003383 active site 315730003384 Uncharacterized conserved protein [Function unknown]; Region: COG1624 315730003385 Tic20-like protein; Region: Tic20; pfam09685 315730003386 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 315730003387 DNA binding residues [nucleotide binding] 315730003388 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315730003389 dimer interface [polypeptide binding]; other site 315730003390 Uncharacterized conserved protein [Function unknown]; Region: COG4997 315730003391 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 315730003392 replicative DNA helicase; Provisional; Region: PRK06749 315730003393 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 315730003394 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 315730003395 Walker A motif; other site 315730003396 ATP binding site [chemical binding]; other site 315730003397 Walker B motif; other site 315730003398 DNA binding loops [nucleotide binding] 315730003399 Predicted transcriptional regulators [Transcription]; Region: COG1378 315730003400 Helix-turn-helix domains; Region: HTH; cl00088 315730003401 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 315730003402 C-terminal domain interface [polypeptide binding]; other site 315730003403 sugar binding site [chemical binding]; other site 315730003404 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 315730003405 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 315730003406 EamA-like transporter family; Region: EamA; cl01037 315730003407 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730003408 Helix-turn-helix domains; Region: HTH; cl00088 315730003409 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 315730003410 putative active site [active] 315730003411 putative FMN binding site [chemical binding]; other site 315730003412 putative substrate binding site [chemical binding]; other site 315730003413 putative catalytic residue [active] 315730003414 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 315730003415 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315730003416 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 315730003417 NADH(P)-binding; Region: NAD_binding_10; pfam13460 315730003418 putative NAD(P) binding site [chemical binding]; other site 315730003419 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730003420 NAD(P) binding site [chemical binding]; other site 315730003421 active site 315730003422 PspA/IM30 family; Region: PspA_IM30; pfam04012 315730003423 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730003424 Helix-turn-helix domains; Region: HTH; cl00088 315730003425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730003426 putative substrate translocation pore; other site 315730003427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730003428 Predicted permease; Region: DUF318; pfam03773 315730003429 Predicted permeases [General function prediction only]; Region: COG0701 315730003430 Helix-turn-helix domains; Region: HTH; cl00088 315730003431 Transcriptional regulators [Transcription]; Region: MarR; COG1846 315730003432 Helix-turn-helix domains; Region: HTH; cl00088 315730003433 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 315730003434 ATP synthase I chain; Region: ATP_synt_I; cl09170 315730003435 YolD-like protein; Region: YolD; pfam08863 315730003436 Barstar_AU1054-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor AU1054 found in Burkholderia cenocepacia. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular...; Region: Barstar_AU1054-like; cd05140 315730003437 putative RNAase interaction site [polypeptide binding]; other site 315730003438 Protein of unknown function (DUF3937); Region: DUF3937; pfam13073 315730003439 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 315730003440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730003441 putative substrate translocation pore; other site 315730003442 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730003443 putative DNA binding site [nucleotide binding]; other site 315730003444 dimerization interface [polypeptide binding]; other site 315730003445 putative Zn2+ binding site [ion binding]; other site 315730003446 VanZ like family; Region: VanZ; cl01971 315730003447 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 315730003448 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 315730003449 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 315730003450 Helix-turn-helix domains; Region: HTH; cl00088 315730003451 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 315730003452 dihydroxyacetone kinase; Provisional; Region: PRK14479 315730003453 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 315730003454 DAK2 domain; Region: Dak2; cl03685 315730003455 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 315730003456 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 315730003457 active site 315730003458 dimer interface [polypeptide binding]; other site 315730003459 non-prolyl cis peptide bond; other site 315730003460 insertion regions; other site 315730003461 ATP-grasp domain; Region: ATP-grasp_4; cl03087 315730003462 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 315730003463 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 315730003464 S-layer homology domain; Region: SLH; pfam00395 315730003465 S-layer homology domain; Region: SLH; pfam00395 315730003466 S-layer homology domain; Region: SLH; pfam00395 315730003467 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 315730003468 Helix-turn-helix domains; Region: HTH; cl00088 315730003469 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 315730003470 uridine kinase; Validated; Region: PRK06696 315730003471 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730003472 active site 315730003473 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 315730003474 nudix motif; other site 315730003475 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 315730003476 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 315730003477 putative active site [active] 315730003478 catalytic site [active] 315730003479 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 315730003480 PLD-like domain; Region: PLDc_2; pfam13091 315730003481 putative active site [active] 315730003482 catalytic site [active] 315730003483 Uncharacterized conserved protein [Function unknown]; Region: COG5276 315730003484 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 315730003485 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 315730003486 Erythromycin esterase; Region: Erythro_esteras; pfam05139 315730003487 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315730003488 Helix-turn-helix domains; Region: HTH; cl00088 315730003489 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 315730003490 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 315730003491 Heat induced stress protein YflT; Region: YflT; pfam11181 315730003492 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 315730003493 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 315730003494 anti sigma factor interaction site; other site 315730003495 regulatory phosphorylation site [posttranslational modification]; other site 315730003496 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 315730003497 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730003498 ATP binding site [chemical binding]; other site 315730003499 Mg2+ binding site [ion binding]; other site 315730003500 G-X-G motif; other site 315730003501 RNA polymerase sigma-B factor; Region: Sigma_B; TIGR02941 315730003502 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730003503 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 315730003504 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730003505 DNA binding residues [nucleotide binding] 315730003506 Ferritin-like domain; Region: Ferritin; pfam00210 315730003507 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 315730003508 dinuclear metal binding motif [ion binding]; other site 315730003509 Response regulator receiver domain; Region: Response_reg; pfam00072 315730003510 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730003511 active site 315730003512 phosphorylation site [posttranslational modification] 315730003513 intermolecular recognition site; other site 315730003514 dimerization interface [polypeptide binding]; other site 315730003515 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 315730003516 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 315730003517 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 315730003518 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 315730003519 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730003520 CHASE3 domain; Region: CHASE3; cl05000 315730003521 GAF domain; Region: GAF_2; pfam13185 315730003522 GAF domain; Region: GAF; cl15785 315730003523 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730003524 dimer interface [polypeptide binding]; other site 315730003525 phosphorylation site [posttranslational modification] 315730003526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730003527 ATP binding site [chemical binding]; other site 315730003528 Mg2+ binding site [ion binding]; other site 315730003529 G-X-G motif; other site 315730003530 Response regulator receiver domain; Region: Response_reg; pfam00072 315730003531 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730003532 active site 315730003533 phosphorylation site [posttranslational modification] 315730003534 intermolecular recognition site; other site 315730003535 dimerization interface [polypeptide binding]; other site 315730003536 Protein of unknown function (DUF4028); Region: DUF4028; pfam13220 315730003537 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 315730003538 cyanate transporter; Region: CynX; TIGR00896 315730003539 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730003540 putative substrate translocation pore; other site 315730003541 Transcriptional regulators [Transcription]; Region: FadR; COG2186 315730003542 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730003543 DNA-binding site [nucleotide binding]; DNA binding site 315730003544 FCD domain; Region: FCD; cl11656 315730003545 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 315730003546 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 315730003547 NADP binding site [chemical binding]; other site 315730003548 dimer interface [polypeptide binding]; other site 315730003549 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 315730003550 Histidine kinase; Region: HisKA_3; pfam07730 315730003551 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730003552 ATP binding site [chemical binding]; other site 315730003553 Mg2+ binding site [ion binding]; other site 315730003554 G-X-G motif; other site 315730003555 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 315730003556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730003557 active site 315730003558 phosphorylation site [posttranslational modification] 315730003559 intermolecular recognition site; other site 315730003560 dimerization interface [polypeptide binding]; other site 315730003561 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 315730003562 DNA binding residues [nucleotide binding] 315730003563 dimerization interface [polypeptide binding]; other site 315730003564 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 315730003565 YhzD-like protein; Region: YhzD; pfam14120 315730003566 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 315730003567 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 315730003568 active site 315730003569 metal binding site [ion binding]; metal-binding site 315730003570 DNA binding site [nucleotide binding] 315730003571 AAA domain; Region: AAA_27; pfam13514 315730003572 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 315730003573 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 315730003574 generic binding surface II; other site 315730003575 generic binding surface I; other site 315730003576 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 315730003577 Zn2+ binding site [ion binding]; other site 315730003578 Mg2+ binding site [ion binding]; other site 315730003579 Proteins of 100 residues with WXG; Region: WXG100; cl02005 315730003580 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 315730003581 HNH/ENDO VII superfamily nuclease with conserved GHE residues; Region: GH-E; pfam14410 315730003582 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 315730003583 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 315730003584 Protein of unknown function (DUF2185); Region: DUF2185; cl02019 315730003585 Protein of unknown function (DUF2185); Region: DUF2185; cl02019 315730003586 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 315730003587 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730003588 Zn binding site [ion binding]; other site 315730003589 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 315730003590 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730003591 Zn binding site [ion binding]; other site 315730003592 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 315730003593 Zn binding site [ion binding]; other site 315730003594 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 315730003595 Zn binding site [ion binding]; other site 315730003596 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315730003597 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 315730003598 TPR motif; other site 315730003599 binding surface 315730003600 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730003601 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315730003602 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 315730003603 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 315730003604 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 315730003605 Domain of unknown function (DUF3994); Region: DUF3994; pfam13159 315730003606 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730003607 non-specific DNA binding site [nucleotide binding]; other site 315730003608 salt bridge; other site 315730003609 sequence-specific DNA binding site [nucleotide binding]; other site 315730003610 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 315730003611 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 315730003612 amphipathic channel; other site 315730003613 Asn-Pro-Ala signature motifs; other site 315730003614 glycerol kinase; Provisional; Region: glpK; PRK00047 315730003615 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 315730003616 N- and C-terminal domain interface [polypeptide binding]; other site 315730003617 active site 315730003618 MgATP binding site [chemical binding]; other site 315730003619 catalytic site [active] 315730003620 metal binding site [ion binding]; metal-binding site 315730003621 glycerol binding site [chemical binding]; other site 315730003622 homotetramer interface [polypeptide binding]; other site 315730003623 homodimer interface [polypeptide binding]; other site 315730003624 FBP binding site [chemical binding]; other site 315730003625 protein IIAGlc interface [polypeptide binding]; other site 315730003626 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 315730003627 Helix-turn-helix domains; Region: HTH; cl00088 315730003628 VanZ like family; Region: VanZ; cl01971 315730003629 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 315730003630 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730003631 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 315730003632 Helix-turn-helix domains; Region: HTH; cl00088 315730003633 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 315730003634 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 315730003635 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730003636 Family description; Region: UvrD_C_2; cl15862 315730003637 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 315730003638 PPIC-type PPIASE domain; Region: Rotamase; cl08278 315730003639 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 315730003640 transcriptional regulator Hpr; Provisional; Region: PRK13777 315730003641 Helix-turn-helix domains; Region: HTH; cl00088 315730003642 YtxH-like protein; Region: YtxH; cl02079 315730003643 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 315730003644 HIT family signature motif; other site 315730003645 catalytic residue [active] 315730003646 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 315730003647 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 315730003648 Walker A/P-loop; other site 315730003649 ATP binding site [chemical binding]; other site 315730003650 Q-loop/lid; other site 315730003651 ABC transporter signature motif; other site 315730003652 Walker B; other site 315730003653 D-loop; other site 315730003654 H-loop/switch region; other site 315730003655 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 315730003656 EcsC protein family; Region: EcsC; pfam12787 315730003657 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 315730003658 Cysteine-rich domain; Region: CCG; pfam02754 315730003659 Cysteine-rich domain; Region: CCG; pfam02754 315730003660 iron-sulfur cluster-binding protein; Region: TIGR00273 315730003661 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 315730003662 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 315730003663 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 315730003664 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation,' the process of...; Region: Lipase_3; cd00519 315730003665 active site flap/lid [active] 315730003666 nucleophilic elbow; other site 315730003667 catalytic triad [active] 315730003668 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730003669 Helix-turn-helix domains; Region: HTH; cl00088 315730003670 Bacterial PH domain; Region: DUF304; cl01348 315730003671 Predicted membrane protein [Function unknown]; Region: COG3428 315730003672 Bacterial PH domain; Region: DUF304; cl01348 315730003673 Bacterial PH domain; Region: DUF304; cl01348 315730003674 Bacterial PH domain; Region: DUF304; cl01348 315730003675 Protein of unknown function (DUF975); Region: DUF975; cl10504 315730003676 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 315730003677 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730003678 Helix-turn-helix domains; Region: HTH; cl00088 315730003679 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 315730003680 Collagen binding domain; Region: Collagen_bind; pfam05737 315730003681 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315730003682 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 315730003683 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315730003684 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315730003685 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315730003686 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315730003687 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315730003688 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315730003689 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 315730003690 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315730003691 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315730003692 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315730003693 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315730003694 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315730003695 Bacterial PH domain; Region: DUF304; cl01348 315730003696 Predicted membrane protein [Function unknown]; Region: COG3428 315730003697 Bacterial PH domain; Region: DUF304; cl01348 315730003698 Bacterial PH domain; Region: DUF304; cl01348 315730003699 Bacterial PH domain; Region: DUF304; cl01348 315730003700 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 315730003701 Transglycosylase; Region: Transgly; cl07896 315730003702 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 315730003703 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730003704 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 315730003705 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 315730003706 substrate binding site [chemical binding]; other site 315730003707 active site 315730003708 ferrochelatase; Provisional; Region: PRK12435 315730003709 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 315730003710 C-terminal domain interface [polypeptide binding]; other site 315730003711 active site 315730003712 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 315730003713 active site 315730003714 N-terminal domain interface [polypeptide binding]; other site 315730003715 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 315730003716 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 315730003717 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 315730003718 generic binding surface I; other site 315730003719 generic binding surface II; other site 315730003720 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 315730003721 putative active site [active] 315730003722 putative catalytic site [active] 315730003723 putative Mg binding site IVb [ion binding]; other site 315730003724 putative phosphate binding site [ion binding]; other site 315730003725 putative DNA binding site [nucleotide binding]; other site 315730003726 putative Mg binding site IVa [ion binding]; other site 315730003727 Helix-turn-helix domains; Region: HTH; cl00088 315730003728 Predicted membrane protein [Function unknown]; Region: COG1511 315730003729 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 315730003730 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 315730003731 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 315730003732 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 315730003733 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 315730003734 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 315730003735 ABC-2 type transporter; Region: ABC2_membrane; cl11417 315730003736 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 315730003737 Yip1 domain; Region: Yip1; cl12048 315730003738 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315730003739 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730003740 Coenzyme A binding pocket [chemical binding]; other site 315730003741 Transcriptional regulators [Transcription]; Region: PurR; COG1609 315730003742 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315730003743 DNA binding site [nucleotide binding] 315730003744 domain linker motif; other site 315730003745 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 315730003746 putative dimerization interface [polypeptide binding]; other site 315730003747 putative ligand binding site [chemical binding]; other site 315730003748 YhfH-like protein; Region: YhfH; pfam14149 315730003749 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315730003750 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 315730003751 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 315730003752 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 315730003753 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 315730003754 AMP-binding enzyme; Region: AMP-binding; cl15778 315730003755 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 315730003756 heme-binding site [chemical binding]; other site 315730003757 S-layer homology domain; Region: SLH; pfam00395 315730003758 S-layer homology domain; Region: SLH; pfam00395 315730003759 S-layer homology domain; Region: SLH; pfam00395 315730003760 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 315730003761 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 315730003762 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 315730003763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730003764 dimer interface [polypeptide binding]; other site 315730003765 conserved gate region; other site 315730003766 putative PBP binding loops; other site 315730003767 ABC-ATPase subunit interface; other site 315730003768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730003769 dimer interface [polypeptide binding]; other site 315730003770 conserved gate region; other site 315730003771 putative PBP binding loops; other site 315730003772 ABC-ATPase subunit interface; other site 315730003773 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 315730003774 Part of the ABC transporter complex cysAWTP involved in sulfate import. Responsible for energy coupling to the transport system. The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296 315730003775 Walker A/P-loop; other site 315730003776 ATP binding site [chemical binding]; other site 315730003777 Q-loop/lid; other site 315730003778 ABC transporter signature motif; other site 315730003779 Walker B; other site 315730003780 D-loop; other site 315730003781 H-loop/switch region; other site 315730003782 TOBE-like domain; Region: TOBE_3; pfam12857 315730003783 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 315730003784 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 315730003785 putative active site [active] 315730003786 putative metal binding site [ion binding]; other site 315730003787 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 315730003788 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 315730003789 Putative zinc-finger; Region: zf-HC2; cl15806 315730003790 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 315730003791 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 315730003792 RNA polymerase sigma factor; Provisional; Region: PRK12541 315730003793 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730003794 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730003795 DNA binding residues [nucleotide binding] 315730003796 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315730003797 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 315730003798 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315730003799 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 315730003800 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730003801 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730003802 dimer interface [polypeptide binding]; other site 315730003803 phosphorylation site [posttranslational modification] 315730003804 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730003805 ATP binding site [chemical binding]; other site 315730003806 Mg2+ binding site [ion binding]; other site 315730003807 G-X-G motif; other site 315730003808 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730003809 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730003810 active site 315730003811 phosphorylation site [posttranslational modification] 315730003812 intermolecular recognition site; other site 315730003813 dimerization interface [polypeptide binding]; other site 315730003814 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730003815 DNA binding site [nucleotide binding] 315730003816 CAAX protease self-immunity; Region: Abi; cl00558 315730003817 Peptidase family M48; Region: Peptidase_M48; cl12018 315730003818 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 315730003819 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730003820 dimerization interface [polypeptide binding]; other site 315730003821 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315730003822 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315730003823 dimer interface [polypeptide binding]; other site 315730003824 putative CheW interface [polypeptide binding]; other site 315730003825 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 315730003826 EamA-like transporter family; Region: EamA; cl01037 315730003827 EamA-like transporter family; Region: EamA; cl01037 315730003828 S-layer homology domain; Region: SLH; pfam00395 315730003829 S-layer homology domain; Region: SLH; pfam00395 315730003830 S-layer homology domain; Region: SLH; pfam00395 315730003831 S-layer homology domain; Region: SLH; pfam00395 315730003832 S-layer homology domain; Region: SLH; pfam00395 315730003833 S-layer homology domain; Region: SLH; pfam00395 315730003834 malate synthase A; Region: malate_syn_A; TIGR01344 315730003835 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 315730003836 active site 315730003837 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 315730003838 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 315730003839 tetramer interface [polypeptide binding]; other site 315730003840 active site 315730003841 Mg2+/Mn2+ binding site [ion binding]; other site 315730003842 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 315730003843 DNA-binding site [nucleotide binding]; DNA binding site 315730003844 RNA-binding motif; other site 315730003845 ComK protein; Region: ComK; cl11560 315730003846 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 315730003847 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 315730003848 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 315730003849 Catalytic site [active] 315730003850 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 315730003851 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 315730003852 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 315730003853 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 315730003854 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730003855 Family description; Region: UvrD_C_2; cl15862 315730003856 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 315730003857 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 315730003858 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 315730003859 A new structural DNA glycosylase; Region: AlkD_like; cd06561 315730003860 active site 315730003861 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 315730003862 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 315730003863 Spore germination protein GerPC; Region: GerPC; pfam10737 315730003864 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 315730003865 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 315730003866 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 315730003867 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 315730003868 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 315730003869 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315730003870 inhibitor-cofactor binding pocket; inhibition site 315730003871 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730003872 catalytic residue [active] 315730003873 Protein of unknown function (DUF1516); Region: DUF1516; cl11654 315730003874 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 315730003875 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 315730003876 active site 315730003877 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 315730003878 dimer interface [polypeptide binding]; other site 315730003879 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 315730003880 Ligand Binding Site [chemical binding]; other site 315730003881 Molecular Tunnel; other site 315730003882 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 315730003883 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 315730003884 tetramer interface [polypeptide binding]; other site 315730003885 heme binding pocket [chemical binding]; other site 315730003886 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 315730003887 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 315730003888 active site 315730003889 catalytic site [active] 315730003890 Protein of unknown function (DUF520); Region: DUF520; cl00723 315730003891 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 315730003892 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 315730003893 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 315730003894 RNA binding site [nucleotide binding]; other site 315730003895 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 315730003896 homodimer interface [polypeptide binding]; other site 315730003897 putative substrate binding pocket [chemical binding]; other site 315730003898 diiron center [ion binding]; other site 315730003899 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 315730003900 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 315730003901 PPIC-type PPIASE domain; Region: Rotamase; cl08278 315730003902 Uncharacterized conserved protein [Function unknown]; Region: COG1284 315730003903 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315730003904 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 315730003905 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 315730003906 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730003907 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 315730003908 active site 315730003909 motif I; other site 315730003910 motif II; other site 315730003911 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 315730003912 YjzC-like protein; Region: YjzC; pfam14168 315730003913 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 315730003914 Clp amino terminal domain; Region: Clp_N; pfam02861 315730003915 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730003916 Walker A motif; other site 315730003917 ATP binding site [chemical binding]; other site 315730003918 Walker B motif; other site 315730003919 arginine finger; other site 315730003920 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730003921 Walker A motif; other site 315730003922 ATP binding site [chemical binding]; other site 315730003923 Walker B motif; other site 315730003924 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 315730003925 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 315730003926 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 315730003927 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 315730003928 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730003929 ComZ; Region: ComZ; pfam10815 315730003930 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 315730003931 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 315730003932 dimer interface [polypeptide binding]; other site 315730003933 active site 315730003934 CoA binding pocket [chemical binding]; other site 315730003935 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 315730003936 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 315730003937 dimer interface [polypeptide binding]; other site 315730003938 active site 315730003939 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 315730003940 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 315730003941 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 315730003942 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 315730003943 active site 315730003944 HIGH motif; other site 315730003945 dimer interface [polypeptide binding]; other site 315730003946 KMSKS motif; other site 315730003947 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 315730003948 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 315730003949 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 315730003950 peptide binding site [polypeptide binding]; other site 315730003951 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 315730003952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730003953 dimer interface [polypeptide binding]; other site 315730003954 conserved gate region; other site 315730003955 putative PBP binding loops; other site 315730003956 ABC-ATPase subunit interface; other site 315730003957 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 315730003958 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 315730003959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730003960 dimer interface [polypeptide binding]; other site 315730003961 conserved gate region; other site 315730003962 putative PBP binding loops; other site 315730003963 ABC-ATPase subunit interface; other site 315730003964 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 315730003965 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 315730003966 Walker A/P-loop; other site 315730003967 ATP binding site [chemical binding]; other site 315730003968 Q-loop/lid; other site 315730003969 ABC transporter signature motif; other site 315730003970 Walker B; other site 315730003971 D-loop; other site 315730003972 H-loop/switch region; other site 315730003973 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 315730003974 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 315730003975 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 315730003976 Walker A/P-loop; other site 315730003977 ATP binding site [chemical binding]; other site 315730003978 Q-loop/lid; other site 315730003979 ABC transporter signature motif; other site 315730003980 Walker B; other site 315730003981 D-loop; other site 315730003982 H-loop/switch region; other site 315730003983 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 315730003984 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 315730003985 MatE; Region: MatE; cl10513 315730003986 MatE; Region: MatE; cl10513 315730003987 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 315730003988 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 315730003989 peptide binding site [polypeptide binding]; other site 315730003990 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 315730003991 ArsC family; Region: ArsC; pfam03960 315730003992 putative catalytic residues [active] 315730003993 thiol/disulfide switch; other site 315730003994 Integral membrane protein TerC family; Region: TerC; cl10468 315730003995 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 315730003996 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 315730003997 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 315730003998 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 315730003999 putative active site [active] 315730004000 catalytic site [active] 315730004001 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 315730004002 putative active site [active] 315730004003 catalytic site [active] 315730004004 Competence protein CoiA-like family; Region: CoiA; cl11541 315730004005 oligoendopeptidase F; Region: pepF; TIGR00181 315730004006 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 315730004007 active site 315730004008 Zn binding site [ion binding]; other site 315730004009 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 315730004010 Thioredoxin; Region: Thioredoxin_5; pfam13743 315730004011 catalytic residues [active] 315730004012 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 315730004013 apolar tunnel; other site 315730004014 heme binding site [chemical binding]; other site 315730004015 dimerization interface [polypeptide binding]; other site 315730004016 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 315730004017 putative active site [active] 315730004018 putative metal binding residues [ion binding]; other site 315730004019 signature motif; other site 315730004020 putative triphosphate binding site [ion binding]; other site 315730004021 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 315730004022 synthetase active site [active] 315730004023 NTP binding site [chemical binding]; other site 315730004024 metal binding site [ion binding]; metal-binding site 315730004025 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 315730004026 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 315730004027 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 315730004028 active site 315730004029 Hep_Hag; Region: Hep_Hag; pfam05658 315730004030 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 315730004031 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 315730004032 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 315730004033 active site 315730004034 metal binding site [ion binding]; metal-binding site 315730004035 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 315730004036 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 315730004037 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 315730004038 active site 315730004039 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730004040 S-adenosylmethionine binding site [chemical binding]; other site 315730004041 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730004042 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 315730004043 putative metal binding site; other site 315730004044 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730004045 binding surface 315730004046 TPR motif; other site 315730004047 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730004048 S-adenosylmethionine binding site [chemical binding]; other site 315730004049 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 315730004050 catalytic residues [active] 315730004051 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 315730004052 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 315730004053 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 315730004054 substrate binding site; other site 315730004055 tetramer interface; other site 315730004056 Cupin domain; Region: Cupin_2; cl09118 315730004057 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 315730004058 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 315730004059 NAD binding site [chemical binding]; other site 315730004060 substrate binding site [chemical binding]; other site 315730004061 homodimer interface [polypeptide binding]; other site 315730004062 active site 315730004063 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 315730004064 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 315730004065 NADP binding site [chemical binding]; other site 315730004066 active site 315730004067 putative substrate binding site [chemical binding]; other site 315730004068 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 315730004069 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 315730004070 NAD binding site [chemical binding]; other site 315730004071 homotetramer interface [polypeptide binding]; other site 315730004072 homodimer interface [polypeptide binding]; other site 315730004073 substrate binding site [chemical binding]; other site 315730004074 active site 315730004075 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 315730004076 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 315730004077 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 315730004078 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 315730004079 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 315730004080 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730004081 Family description; Region: UvrD_C_2; cl15862 315730004082 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730004083 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730004084 Coenzyme A binding pocket [chemical binding]; other site 315730004085 hypothetical protein; Provisional; Region: PRK13679 315730004086 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 315730004087 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315730004088 Putative esterase; Region: Esterase; pfam00756 315730004089 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 315730004090 EamA-like transporter family; Region: EamA; cl01037 315730004091 EamA-like transporter family; Region: EamA; cl01037 315730004092 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 315730004093 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 315730004094 ligand binding site [chemical binding]; other site 315730004095 flexible hinge region; other site 315730004096 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 315730004097 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 315730004098 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 315730004099 Sodium:solute symporter family; Region: SSF; cl00456 315730004100 anthranilate synthase component I; Provisional; Region: PRK13570 315730004101 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 315730004102 chorismate binding enzyme; Region: Chorismate_bind; cl10555 315730004103 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 315730004104 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 315730004105 glutamine binding [chemical binding]; other site 315730004106 catalytic triad [active] 315730004107 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 315730004108 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 315730004109 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 315730004110 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 315730004111 active site 315730004112 ribulose/triose binding site [chemical binding]; other site 315730004113 phosphate binding site [ion binding]; other site 315730004114 substrate (anthranilate) binding pocket [chemical binding]; other site 315730004115 product (indole) binding pocket [chemical binding]; other site 315730004116 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 315730004117 active site 315730004118 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 315730004119 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 315730004120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730004121 catalytic residue [active] 315730004122 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 315730004123 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 315730004124 substrate binding site [chemical binding]; other site 315730004125 active site 315730004126 catalytic residues [active] 315730004127 heterodimer interface [polypeptide binding]; other site 315730004128 Protein of unknown function (DUF4029); Region: DUF4029; pfam13221 315730004129 L-lactate permease; Region: Lactate_perm; cl00701 315730004130 Uncharacterized conserved protein [Function unknown]; Region: COG5634 315730004131 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 315730004132 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 315730004133 Predicted membrane protein [Function unknown]; Region: COG4640 315730004134 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 315730004135 YARHG domain; Region: YARHG; pfam13308 315730004136 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 315730004137 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315730004138 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 315730004139 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730004140 Protein of unknown function (DUF3908); Region: DUF3908; pfam13048 315730004141 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730004142 S-adenosylmethionine binding site [chemical binding]; other site 315730004143 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 315730004144 NADPH bind site [chemical binding]; other site 315730004145 putative FMN binding site [chemical binding]; other site 315730004146 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 315730004147 putative FMN binding site [chemical binding]; other site 315730004148 NADPH bind site [chemical binding]; other site 315730004149 MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816 315730004150 YcaO-like family; Region: YcaO; pfam02624 315730004151 Uncharacterized conserved protein [Function unknown]; Region: COG1944; cl09146 315730004152 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 315730004153 MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816 315730004154 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 315730004155 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 315730004156 E3 interaction surface; other site 315730004157 lipoyl attachment site [posttranslational modification]; other site 315730004158 e3 binding domain; Region: E3_binding; pfam02817 315730004159 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 315730004160 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 315730004161 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 315730004162 TPP-binding site [chemical binding]; other site 315730004163 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 315730004164 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730004165 salt bridge; other site 315730004166 non-specific DNA binding site [nucleotide binding]; other site 315730004167 sequence-specific DNA binding site [nucleotide binding]; other site 315730004168 Domain of unknown function (DUF3976); Region: DUF3976; pfam13121 315730004169 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 315730004170 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 315730004171 active site 315730004172 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 315730004173 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 315730004174 Putative catalytic domain of uncharacterized hypothetical proteins closely related to Nuc, , an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar2; cd09174 315730004175 PLD-like domain; Region: PLDc_2; pfam13091 315730004176 putative active site [active] 315730004177 catalytic site [active] 315730004178 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 315730004179 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 315730004180 catalytic residues [active] 315730004181 catalytic nucleophile [active] 315730004182 Presynaptic Site I dimer interface [polypeptide binding]; other site 315730004183 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 315730004184 Synaptic Flat tetramer interface [polypeptide binding]; other site 315730004185 Synaptic Site I dimer interface [polypeptide binding]; other site 315730004186 DNA binding site [nucleotide binding] 315730004187 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 315730004188 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 315730004189 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 315730004190 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 315730004191 Int/Topo IB signature motif; other site 315730004192 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 315730004193 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 315730004194 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 315730004195 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 315730004196 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 315730004197 Catalytic site [active] 315730004198 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 315730004199 Helix-turn-helix domains; Region: HTH; cl00088 315730004200 putative transposase OrfB; Reviewed; Region: PHA02517 315730004201 HTH-like domain; Region: HTH_21; pfam13276 315730004202 Integrase core domain; Region: rve; cl01316 315730004203 Integrase core domain; Region: rve_3; cl15866 315730004204 Domain of unknown function (DUF4047); Region: DUF4047; pfam13256 315730004205 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 315730004206 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730004207 non-specific DNA binding site [nucleotide binding]; other site 315730004208 salt bridge; other site 315730004209 sequence-specific DNA binding site [nucleotide binding]; other site 315730004210 Anti-repressor SinI; Region: SinI; pfam08671 315730004211 Anti-repressor SinI; Region: SinI; pfam08671 315730004212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 315730004213 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 315730004214 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 315730004215 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 315730004216 NAD(P) binding site [chemical binding]; other site 315730004217 catalytic residues [active] 315730004218 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 315730004219 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 315730004220 Walker A/P-loop; other site 315730004221 ATP binding site [chemical binding]; other site 315730004222 Q-loop/lid; other site 315730004223 ABC transporter signature motif; other site 315730004224 Walker B; other site 315730004225 D-loop; other site 315730004226 H-loop/switch region; other site 315730004227 TOBE domain; Region: TOBE_2; cl01440 315730004228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730004229 dimer interface [polypeptide binding]; other site 315730004230 conserved gate region; other site 315730004231 putative PBP binding loops; other site 315730004232 ABC-ATPase subunit interface; other site 315730004233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730004234 dimer interface [polypeptide binding]; other site 315730004235 conserved gate region; other site 315730004236 putative PBP binding loops; other site 315730004237 ABC-ATPase subunit interface; other site 315730004238 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 315730004239 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 315730004240 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 315730004241 active site 315730004242 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 315730004243 Protein export membrane protein; Region: SecD_SecF; cl14618 315730004244 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 315730004245 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 315730004246 active site 315730004247 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 315730004248 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 315730004249 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 315730004250 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 315730004251 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 315730004252 Cysteine-rich domain; Region: CCG; pfam02754 315730004253 Cysteine-rich domain; Region: CCG; pfam02754 315730004254 FAD binding domain; Region: FAD_binding_4; pfam01565 315730004255 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 315730004256 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 315730004257 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 315730004258 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 315730004259 metal binding site [ion binding]; metal-binding site 315730004260 Helix-turn-helix domains; Region: HTH; cl00088 315730004261 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 315730004262 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 315730004263 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730004264 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730004265 active site 315730004266 phosphorylation site [posttranslational modification] 315730004267 intermolecular recognition site; other site 315730004268 dimerization interface [polypeptide binding]; other site 315730004269 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730004270 DNA binding site [nucleotide binding] 315730004271 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730004272 dimerization interface [polypeptide binding]; other site 315730004273 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730004274 dimer interface [polypeptide binding]; other site 315730004275 phosphorylation site [posttranslational modification] 315730004276 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730004277 ATP binding site [chemical binding]; other site 315730004278 Mg2+ binding site [ion binding]; other site 315730004279 G-X-G motif; other site 315730004280 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730004281 DNA-binding site [nucleotide binding]; DNA binding site 315730004282 FCD domain; Region: FCD; cl11656 315730004283 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 315730004284 Cysteine-rich domain; Region: CCG; pfam02754 315730004285 Cysteine-rich domain; Region: CCG; pfam02754 315730004286 iron-sulfur cluster-binding protein; Region: TIGR00273 315730004287 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 315730004288 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 315730004289 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 315730004290 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 315730004291 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 315730004292 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 315730004293 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 315730004294 Integral membrane protein TerC family; Region: TerC; cl10468 315730004295 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 315730004296 Cation transport protein; Region: TrkH; cl10514 315730004297 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 315730004298 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 315730004299 dimer interaction site [polypeptide binding]; other site 315730004300 substrate-binding tunnel; other site 315730004301 active site 315730004302 catalytic site [active] 315730004303 substrate binding site [chemical binding]; other site 315730004304 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 315730004305 Helix-turn-helix domains; Region: HTH; cl00088 315730004306 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 315730004307 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 315730004308 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730004309 NAD(P) binding site [chemical binding]; other site 315730004310 active site 315730004311 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 315730004312 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 315730004313 PHB de-polymerase C-terminus; Region: PHB_depo_C; cl14907 315730004314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730004315 FAD dependent oxidoreductase; Region: DAO; pfam01266 315730004316 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 315730004317 Cation transport protein; Region: TrkH; cl10514 315730004318 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 315730004319 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 315730004320 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 315730004321 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 315730004322 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730004323 Walker A/P-loop; other site 315730004324 ATP binding site [chemical binding]; other site 315730004325 Q-loop/lid; other site 315730004326 ABC transporter signature motif; other site 315730004327 Walker B; other site 315730004328 D-loop; other site 315730004329 H-loop/switch region; other site 315730004330 TOBE domain; Region: TOBE_2; cl01440 315730004331 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 315730004332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730004333 dimer interface [polypeptide binding]; other site 315730004334 conserved gate region; other site 315730004335 putative PBP binding loops; other site 315730004336 ABC-ATPase subunit interface; other site 315730004337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730004338 dimer interface [polypeptide binding]; other site 315730004339 conserved gate region; other site 315730004340 putative PBP binding loops; other site 315730004341 ABC-ATPase subunit interface; other site 315730004342 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 315730004343 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730004344 motif II; other site 315730004345 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 315730004346 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 315730004347 catalytic residue [active] 315730004348 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 315730004349 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 315730004350 Helix-turn-helix domains; Region: HTH; cl00088 315730004351 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 315730004352 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 315730004353 heme-binding site [chemical binding]; other site 315730004354 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 315730004355 Leucine rich repeat; Region: LRR_8; pfam13855 315730004356 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 315730004357 Leucine-rich repeats; other site 315730004358 Substrate binding site [chemical binding]; other site 315730004359 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 315730004360 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 315730004361 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 315730004362 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 315730004363 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 315730004364 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 315730004365 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 315730004366 LRR adjacent; Region: LRR_adjacent; pfam08191 315730004367 S-layer homology domain; Region: SLH; pfam00395 315730004368 S-layer homology domain; Region: SLH; pfam00395 315730004369 S-layer homology domain; Region: SLH; pfam00395 315730004370 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 315730004371 intersubunit interface [polypeptide binding]; other site 315730004372 active site 315730004373 Zn2+ binding site [ion binding]; other site 315730004374 FOG: CBS domain [General function prediction only]; Region: COG0517 315730004375 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 315730004376 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 315730004377 NodB motif; other site 315730004378 putative active site [active] 315730004379 putative catalytic site [active] 315730004380 Zn binding site [ion binding]; other site 315730004381 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 315730004382 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 315730004383 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730004384 dimer interface [polypeptide binding]; other site 315730004385 phosphorylation site [posttranslational modification] 315730004386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730004387 ATP binding site [chemical binding]; other site 315730004388 Mg2+ binding site [ion binding]; other site 315730004389 G-X-G motif; other site 315730004390 Helix-turn-helix domains; Region: HTH; cl00088 315730004391 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 315730004392 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 315730004393 active site 315730004394 Zn binding site [ion binding]; other site 315730004395 DinB superfamily; Region: DinB_2; pfam12867 315730004396 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 315730004397 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730004398 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730004399 dimer interface [polypeptide binding]; other site 315730004400 phosphorylation site [posttranslational modification] 315730004401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730004402 ATP binding site [chemical binding]; other site 315730004403 Mg2+ binding site [ion binding]; other site 315730004404 G-X-G motif; other site 315730004405 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 315730004406 Ligand Binding Site [chemical binding]; other site 315730004407 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 315730004408 active site 315730004409 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 315730004410 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 315730004411 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 315730004412 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 315730004413 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730004414 Coenzyme A binding pocket [chemical binding]; other site 315730004415 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 315730004416 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 315730004417 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 315730004418 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 315730004419 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 315730004420 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 315730004421 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 315730004422 dimer interface [polypeptide binding]; other site 315730004423 putative radical transfer pathway; other site 315730004424 diiron center [ion binding]; other site 315730004425 tyrosyl radical; other site 315730004426 amino acid transporter; Region: 2A0306; TIGR00909 315730004427 Spore germination protein; Region: Spore_permease; cl15802 315730004428 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 315730004429 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 315730004430 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 315730004431 NAD(P) binding site [chemical binding]; other site 315730004432 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 315730004433 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 315730004434 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 315730004435 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 315730004436 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730004437 Walker A motif; other site 315730004438 ATP binding site [chemical binding]; other site 315730004439 Walker B motif; other site 315730004440 arginine finger; other site 315730004441 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 315730004442 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 315730004443 tetramerization interface [polypeptide binding]; other site 315730004444 NAD(P) binding site [chemical binding]; other site 315730004445 catalytic residues [active] 315730004446 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 315730004447 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315730004448 inhibitor-cofactor binding pocket; inhibition site 315730004449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730004450 catalytic residue [active] 315730004451 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730004452 DNA-binding site [nucleotide binding]; DNA binding site 315730004453 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 315730004454 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 315730004455 Walker A/P-loop; other site 315730004456 ATP binding site [chemical binding]; other site 315730004457 Q-loop/lid; other site 315730004458 ABC transporter signature motif; other site 315730004459 Walker B; other site 315730004460 D-loop; other site 315730004461 H-loop/switch region; other site 315730004462 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315730004463 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 315730004464 Walker A/P-loop; other site 315730004465 ATP binding site [chemical binding]; other site 315730004466 Q-loop/lid; other site 315730004467 ABC transporter signature motif; other site 315730004468 Walker B; other site 315730004469 D-loop; other site 315730004470 H-loop/switch region; other site 315730004471 ABC-2 type transporter; Region: ABC2_membrane; cl11417 315730004472 CAAX protease self-immunity; Region: Abi; cl00558 315730004473 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 315730004474 Protein of unknown function (DUF3913); Region: DUF3913; pfam13052 315730004475 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 315730004476 Helix-turn-helix domains; Region: HTH; cl00088 315730004477 Uncharacterized conserved protein [Function unknown]; Region: COG2128 315730004478 Isochorismatase family; Region: Isochorismatase; pfam00857 315730004479 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 315730004480 catalytic triad [active] 315730004481 conserved cis-peptide bond; other site 315730004482 SseB protein; Region: SseB; cl06279 315730004483 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 315730004484 dimer interface [polypeptide binding]; other site 315730004485 catalytic triad [active] 315730004486 Nitronate monooxygenase; Region: NMO; pfam03060 315730004487 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 315730004488 FMN binding site [chemical binding]; other site 315730004489 substrate binding site [chemical binding]; other site 315730004490 putative catalytic residue [active] 315730004491 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 315730004492 DltD N-terminal region; Region: DltD_N; pfam04915 315730004493 DltD central region; Region: DltD_M; pfam04918 315730004494 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 315730004495 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315730004496 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 315730004497 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 315730004498 AMP-binding enzyme; Region: AMP-binding; cl15778 315730004499 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 315730004500 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 315730004501 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 315730004502 metal binding site [ion binding]; metal-binding site 315730004503 dimer interface [polypeptide binding]; other site 315730004504 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 315730004505 Phosphotransferase enzyme family; Region: APH; pfam01636 315730004506 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315730004507 active site 315730004508 substrate binding site [chemical binding]; other site 315730004509 ATP binding site [chemical binding]; other site 315730004510 multidrug efflux protein; Reviewed; Region: PRK01766 315730004511 MatE; Region: MatE; cl10513 315730004512 MatE; Region: MatE; cl10513 315730004513 Bacitracin resistance protein BacA; Region: BacA; cl00858 315730004514 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 315730004515 hydrophobic ligand binding site; other site 315730004516 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 315730004517 catalytic residues [active] 315730004518 Regulatory protein YrvL; Region: YrvL; pfam14184 315730004519 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315730004520 Helix-turn-helix domains; Region: HTH; cl00088 315730004521 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 315730004522 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 315730004523 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 315730004524 Cation transport protein; Region: TrkH; cl10514 315730004525 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 315730004526 Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214 315730004527 Protein of unknown function (DUF3911); Region: DUF3911; pfam13050 315730004528 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 315730004529 homodimer interface [polypeptide binding]; other site 315730004530 substrate-cofactor binding pocket; other site 315730004531 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730004532 catalytic residue [active] 315730004533 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 315730004534 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 315730004535 PYR/PP interface [polypeptide binding]; other site 315730004536 dimer interface [polypeptide binding]; other site 315730004537 TPP binding site [chemical binding]; other site 315730004538 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 315730004539 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 315730004540 TPP-binding site [chemical binding]; other site 315730004541 dimer interface [polypeptide binding]; other site 315730004542 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 315730004543 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 315730004544 putative valine binding site [chemical binding]; other site 315730004545 dimer interface [polypeptide binding]; other site 315730004546 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 315730004547 ketol-acid reductoisomerase; Provisional; Region: PRK05479 315730004548 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730004549 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 315730004550 2-isopropylmalate synthase; Validated; Region: PRK00915 315730004551 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 315730004552 active site 315730004553 catalytic residues [active] 315730004554 metal binding site [ion binding]; metal-binding site 315730004555 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 315730004556 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 315730004557 tartrate dehydrogenase; Provisional; Region: PRK08194 315730004558 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 315730004559 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 315730004560 substrate binding site [chemical binding]; other site 315730004561 ligand binding site [chemical binding]; other site 315730004562 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 315730004563 substrate binding site [chemical binding]; other site 315730004564 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 315730004565 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 315730004566 dimer interface [polypeptide binding]; other site 315730004567 motif 1; other site 315730004568 active site 315730004569 motif 2; other site 315730004570 motif 3; other site 315730004571 ATP phosphoribosyltransferase; Region: HisG; cl15266 315730004572 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 315730004573 histidinol dehydrogenase; Region: hisD; TIGR00069 315730004574 NAD binding site [chemical binding]; other site 315730004575 dimerization interface [polypeptide binding]; other site 315730004576 product binding site; other site 315730004577 substrate binding site [chemical binding]; other site 315730004578 zinc binding site [ion binding]; other site 315730004579 catalytic residues [active] 315730004580 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 315730004581 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 315730004582 putative active site pocket [active] 315730004583 4-fold oligomerization interface [polypeptide binding]; other site 315730004584 metal binding residues [ion binding]; metal-binding site 315730004585 3-fold/trimer interface [polypeptide binding]; other site 315730004586 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 315730004587 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 315730004588 putative active site [active] 315730004589 oxyanion strand; other site 315730004590 catalytic triad [active] 315730004591 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 315730004592 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 315730004593 catalytic residues [active] 315730004594 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 315730004595 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 315730004596 substrate binding site [chemical binding]; other site 315730004597 glutamase interaction surface [polypeptide binding]; other site 315730004598 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 315730004599 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 315730004600 histidinol-phosphatase; Validated; Region: PRK06740 315730004601 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 315730004602 glyoxylate reductase; Reviewed; Region: PRK13243 315730004603 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730004604 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 315730004605 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 315730004606 Sulfatase; Region: Sulfatase; cl10460 315730004607 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 315730004608 diaminopimelate decarboxylase; Region: lysA; TIGR01048 315730004609 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 315730004610 active site 315730004611 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 315730004612 substrate binding site [chemical binding]; other site 315730004613 catalytic residues [active] 315730004614 dimer interface [polypeptide binding]; other site 315730004615 Uncharacterized small protein (DUF2292); Region: DUF2292; cl02371 315730004616 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 315730004617 Active Sites [active] 315730004618 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 315730004619 ATP-sulfurylase; Region: ATPS; cd00517 315730004620 active site 315730004621 HXXH motif; other site 315730004622 flexible loop; other site 315730004623 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 315730004624 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 315730004625 ligand-binding site [chemical binding]; other site 315730004626 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 315730004627 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 315730004628 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 315730004629 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 315730004630 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 315730004631 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 315730004632 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 315730004633 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 315730004634 putative active site [active] 315730004635 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 315730004636 putative active site [active] 315730004637 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 315730004638 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730004639 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 315730004640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 315730004641 Peptidase family M23; Region: Peptidase_M23; pfam01551 315730004642 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 315730004643 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 315730004644 Protein of unknown function (DUF402); Region: DUF402; cl00979 315730004645 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 315730004646 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 315730004647 transmembrane helices; other site 315730004648 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730004649 Coenzyme A binding pocket [chemical binding]; other site 315730004650 PspA/IM30 family; Region: PspA_IM30; pfam04012 315730004651 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 315730004652 Histidine kinase; Region: HisKA_3; pfam07730 315730004653 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730004654 ATP binding site [chemical binding]; other site 315730004655 Mg2+ binding site [ion binding]; other site 315730004656 G-X-G motif; other site 315730004657 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 315730004658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730004659 active site 315730004660 phosphorylation site [posttranslational modification] 315730004661 intermolecular recognition site; other site 315730004662 dimerization interface [polypeptide binding]; other site 315730004663 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 315730004664 DNA binding residues [nucleotide binding] 315730004665 dimerization interface [polypeptide binding]; other site 315730004666 Protein of unknown function (DUF3992); Region: DUF3922; pfam13059 315730004667 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 315730004668 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 315730004669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730004670 S-adenosylmethionine binding site [chemical binding]; other site 315730004671 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 315730004672 active site 315730004673 putative substrate binding region [chemical binding]; other site 315730004674 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 315730004675 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 315730004676 heme-binding site [chemical binding]; other site 315730004677 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 315730004678 FAD binding pocket [chemical binding]; other site 315730004679 FAD binding motif [chemical binding]; other site 315730004680 phosphate binding motif [ion binding]; other site 315730004681 beta-alpha-beta structure motif; other site 315730004682 NAD binding pocket [chemical binding]; other site 315730004683 Heme binding pocket [chemical binding]; other site 315730004684 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 315730004685 ligand binding site [chemical binding]; other site 315730004686 flexible hinge region; other site 315730004687 Helix-turn-helix domains; Region: HTH; cl00088 315730004688 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 315730004689 Phosphate transporter family; Region: PHO4; cl00396 315730004690 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 315730004691 Transglycosylase; Region: Transgly; cl07896 315730004692 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 315730004693 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730004694 Borrelia burgdorferi virulent strain associated lipoprotein; Region: Borrelia_lipo_1; pfam05714 315730004695 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 315730004696 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 315730004697 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 315730004698 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 315730004699 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 315730004700 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 315730004701 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730004702 dimer interface [polypeptide binding]; other site 315730004703 phosphorylation site [posttranslational modification] 315730004704 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730004705 ATP binding site [chemical binding]; other site 315730004706 Mg2+ binding site [ion binding]; other site 315730004707 G-X-G motif; other site 315730004708 Protein of unknown function DUF72; Region: DUF72; cl00777 315730004709 Protein of unknown function (DUF3924); Region: DUF3924; pfam13062 315730004710 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 315730004711 DNA binding site [nucleotide binding] 315730004712 Int/Topo IB signature motif; other site 315730004713 active site 315730004714 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730004715 dimerization interface [polypeptide binding]; other site 315730004716 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730004717 dimer interface [polypeptide binding]; other site 315730004718 phosphorylation site [posttranslational modification] 315730004719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730004720 ATP binding site [chemical binding]; other site 315730004721 Mg2+ binding site [ion binding]; other site 315730004722 G-X-G motif; other site 315730004723 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 315730004724 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 315730004725 Predicted integral membrane protein [Function unknown]; Region: COG0392 315730004726 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 315730004727 Uncharacterized conserved protein [Function unknown]; Region: COG2898 315730004728 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 315730004729 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 315730004730 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 315730004731 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 315730004732 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 315730004733 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 315730004734 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730004735 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 315730004736 Nucleoside recognition; Region: Gate; cl00486 315730004737 Nucleoside recognition; Region: Gate; cl00486 315730004738 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 315730004739 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315730004740 RNA binding surface [nucleotide binding]; other site 315730004741 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 315730004742 active site 315730004743 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 315730004744 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 315730004745 catalytic residues [active] 315730004746 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 315730004747 ResB-like family; Region: ResB; pfam05140 315730004748 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 315730004749 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 315730004750 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730004751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730004752 active site 315730004753 phosphorylation site [posttranslational modification] 315730004754 intermolecular recognition site; other site 315730004755 dimerization interface [polypeptide binding]; other site 315730004756 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730004757 DNA binding site [nucleotide binding] 315730004758 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 315730004759 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730004760 dimerization interface [polypeptide binding]; other site 315730004761 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 315730004762 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730004763 dimer interface [polypeptide binding]; other site 315730004764 phosphorylation site [posttranslational modification] 315730004765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730004766 ATP binding site [chemical binding]; other site 315730004767 Mg2+ binding site [ion binding]; other site 315730004768 G-X-G motif; other site 315730004769 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 315730004770 Peptidase family M23; Region: Peptidase_M23; pfam01551 315730004771 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 315730004772 putative peptidoglycan binding site; other site 315730004773 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 315730004774 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 315730004775 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 315730004776 DEAD-like helicases superfamily; Region: DEXDc; smart00487 315730004777 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315730004778 ATP binding site [chemical binding]; other site 315730004779 putative Mg++ binding site [ion binding]; other site 315730004780 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315730004781 nucleotide binding region [chemical binding]; other site 315730004782 ATP-binding site [chemical binding]; other site 315730004783 CAAX protease self-immunity; Region: Abi; cl00558 315730004784 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 315730004785 putative peptidoglycan binding site; other site 315730004786 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 315730004787 putative active site [active] 315730004788 putative metal binding site [ion binding]; other site 315730004789 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315730004790 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 315730004791 DNA binding residues [nucleotide binding] 315730004792 B12 binding domain; Region: B12-binding_2; cl03653 315730004793 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 315730004794 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 315730004795 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 315730004796 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 315730004797 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 315730004798 NAD(P) binding site [chemical binding]; other site 315730004799 Domain of unknown function (DUF3961); Region: DUF3961; pfam13106 315730004800 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 315730004801 amidase catalytic site [active] 315730004802 Zn binding residues [ion binding]; other site 315730004803 substrate binding site [chemical binding]; other site 315730004804 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 315730004805 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730004806 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315730004807 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 315730004808 active site 315730004809 homotetramer interface [polypeptide binding]; other site 315730004810 homodimer interface [polypeptide binding]; other site 315730004811 cytidylate kinase; Provisional; Region: cmk; PRK00023 315730004812 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 315730004813 CMP-binding site; other site 315730004814 The sites determining sugar specificity; other site 315730004815 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 315730004816 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 315730004817 RNA binding site [nucleotide binding]; other site 315730004818 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 315730004819 RNA binding site [nucleotide binding]; other site 315730004820 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 315730004821 RNA binding site [nucleotide binding]; other site 315730004822 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 315730004823 RNA binding site [nucleotide binding]; other site 315730004824 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 315730004825 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 315730004826 homotetramer interface [polypeptide binding]; other site 315730004827 FMN binding site [chemical binding]; other site 315730004828 homodimer contacts [polypeptide binding]; other site 315730004829 putative active site [active] 315730004830 putative substrate binding site [chemical binding]; other site 315730004831 YpzI-like protein; Region: YpzI; pfam14140 315730004832 YIEGIA protein; Region: YIEGIA; pfam14045 315730004833 GTP-binding protein Der; Reviewed; Region: PRK00093 315730004834 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 315730004835 G1 box; other site 315730004836 GTP/Mg2+ binding site [chemical binding]; other site 315730004837 Switch I region; other site 315730004838 G2 box; other site 315730004839 Switch II region; other site 315730004840 G3 box; other site 315730004841 G4 box; other site 315730004842 G5 box; other site 315730004843 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 315730004844 G1 box; other site 315730004845 GTP/Mg2+ binding site [chemical binding]; other site 315730004846 Switch I region; other site 315730004847 G2 box; other site 315730004848 G3 box; other site 315730004849 Switch II region; other site 315730004850 G4 box; other site 315730004851 G5 box; other site 315730004852 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 315730004853 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730004854 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 315730004855 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 315730004856 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 315730004857 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; cl09772 315730004858 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 315730004859 IHF dimer interface [polypeptide binding]; other site 315730004860 IHF - DNA interface [nucleotide binding]; other site 315730004861 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 315730004862 homodecamer interface [polypeptide binding]; other site 315730004863 GTP cyclohydrolase I; Provisional; Region: PLN03044 315730004864 active site 315730004865 putative catalytic site residues [active] 315730004866 zinc binding site [ion binding]; other site 315730004867 GTP-CH-I/GFRP interaction surface; other site 315730004868 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 315730004869 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 315730004870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730004871 S-adenosylmethionine binding site [chemical binding]; other site 315730004872 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 315730004873 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 315730004874 substrate binding pocket [chemical binding]; other site 315730004875 chain length determination region; other site 315730004876 substrate-Mg2+ binding site; other site 315730004877 catalytic residues [active] 315730004878 aspartate-rich region 1; other site 315730004879 active site lid residues [active] 315730004880 aspartate-rich region 2; other site 315730004881 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 315730004882 active site 315730004883 multimer interface [polypeptide binding]; other site 315730004884 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 315730004885 Tetramer interface [polypeptide binding]; other site 315730004886 active site 315730004887 FMN-binding site [chemical binding]; other site 315730004888 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 315730004889 active site 315730004890 dimer interface [polypeptide binding]; other site 315730004891 metal binding site [ion binding]; metal-binding site 315730004892 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 315730004893 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315730004894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730004895 homodimer interface [polypeptide binding]; other site 315730004896 catalytic residue [active] 315730004897 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 315730004898 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 315730004899 hinge; other site 315730004900 active site 315730004901 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 315730004902 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 315730004903 binding surface 315730004904 TPR motif; other site 315730004905 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 315730004906 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730004907 binding surface 315730004908 TPR motif; other site 315730004909 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315730004910 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730004911 binding surface 315730004912 TPR motif; other site 315730004913 hypothetical protein; Provisional; Region: PRK03636 315730004914 UPF0302 domain; Region: UPF0302; pfam08864 315730004915 IDEAL domain; Region: IDEAL; cl07452 315730004916 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 315730004917 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 315730004918 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 315730004919 iron-sulfur cluster [ion binding]; other site 315730004920 [2Fe-2S] cluster binding site [ion binding]; other site 315730004921 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 315730004922 interchain domain interface [polypeptide binding]; other site 315730004923 intrachain domain interface; other site 315730004924 heme bH binding site [chemical binding]; other site 315730004925 Qi binding site; other site 315730004926 heme bL binding site [chemical binding]; other site 315730004927 Qo binding site; other site 315730004928 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 315730004929 interchain domain interface [polypeptide binding]; other site 315730004930 intrachain domain interface; other site 315730004931 Qi binding site; other site 315730004932 Qo binding site; other site 315730004933 Cytochrome c; Region: Cytochrom_C; cl11414 315730004934 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 315730004935 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 315730004936 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 315730004937 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 315730004938 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 315730004939 active site 315730004940 Fe-S cluster binding site [ion binding]; other site 315730004941 Uncharacterized conserved protein [Function unknown]; Region: COG1284 315730004942 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315730004943 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315730004944 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 315730004945 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 315730004946 dihydrodipicolinate reductase; Provisional; Region: PRK00048 315730004947 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730004948 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 315730004949 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 315730004950 active site 315730004951 dimer interfaces [polypeptide binding]; other site 315730004952 catalytic residues [active] 315730004953 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 315730004954 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 315730004955 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 315730004956 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 315730004957 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 315730004958 active site 315730004959 NTP binding site [chemical binding]; other site 315730004960 metal binding triad [ion binding]; metal-binding site 315730004961 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 315730004962 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 315730004963 Helix-turn-helix domains; Region: HTH; cl00088 315730004964 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 315730004965 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 315730004966 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 315730004967 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 315730004968 oligomerization interface [polypeptide binding]; other site 315730004969 active site 315730004970 metal binding site [ion binding]; metal-binding site 315730004971 pantoate--beta-alanine ligase; Region: panC; TIGR00018 315730004972 Pantoate-beta-alanine ligase; Region: PanC; cd00560 315730004973 active site 315730004974 ATP-binding site [chemical binding]; other site 315730004975 pantoate-binding site; other site 315730004976 HXXH motif; other site 315730004977 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 315730004978 tetramerization interface [polypeptide binding]; other site 315730004979 active site 315730004980 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 315730004981 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 315730004982 active site 315730004983 substrate binding site [chemical binding]; other site 315730004984 catalytic site [active] 315730004985 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730004986 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730004987 putative Mg++ binding site [ion binding]; other site 315730004988 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730004989 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 315730004990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 315730004991 aspartate aminotransferase; Provisional; Region: PRK05764 315730004992 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315730004993 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730004994 homodimer interface [polypeptide binding]; other site 315730004995 catalytic residue [active] 315730004996 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 315730004997 Helix-turn-helix domains; Region: HTH; cl00088 315730004998 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 315730004999 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 315730005000 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 315730005001 minor groove reading motif; other site 315730005002 helix-hairpin-helix signature motif; other site 315730005003 substrate binding pocket [chemical binding]; other site 315730005004 active site 315730005005 Transglycosylase; Region: Transgly; cl07896 315730005006 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 315730005007 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730005008 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 315730005009 Recombination protein U; Region: RecU; cl01314 315730005010 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 315730005011 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 315730005012 YppF-like protein; Region: YppF; pfam14178 315730005013 YppG-like protein; Region: YppG; pfam14179 315730005014 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 315730005015 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 315730005016 cell division protein GpsB; Provisional; Region: PRK14127 315730005017 DivIVA domain; Region: DivI1A_domain; TIGR03544 315730005018 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 315730005019 THUMP domain; Region: THUMP; cl12076 315730005020 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730005021 Protein of unknown function (DUF3921); Region: DUF3921; pfam13060 315730005022 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 315730005023 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730005024 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730005025 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 315730005026 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 315730005027 active site 315730005028 Zn binding site [ion binding]; other site 315730005029 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730005030 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 315730005031 active site 315730005032 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 315730005033 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315730005034 active site 315730005035 xanthine permease; Region: pbuX; TIGR03173 315730005036 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 315730005037 Predicted membrane protein [Function unknown]; Region: COG2311 315730005038 Protein of unknown function (DUF418); Region: DUF418; cl12135 315730005039 Protein of unknown function (DUF418); Region: DUF418; cl12135 315730005040 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 315730005041 Dynamin family; Region: Dynamin_N; pfam00350 315730005042 G1 box; other site 315730005043 GTP/Mg2+ binding site [chemical binding]; other site 315730005044 G2 box; other site 315730005045 Switch I region; other site 315730005046 G3 box; other site 315730005047 Switch II region; other site 315730005048 G4 box; other site 315730005049 G5 box; other site 315730005050 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730005051 Dynamin family; Region: Dynamin_N; pfam00350 315730005052 G1 box; other site 315730005053 GTP/Mg2+ binding site [chemical binding]; other site 315730005054 G2 box; other site 315730005055 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 315730005056 G3 box; other site 315730005057 Switch II region; other site 315730005058 GTP/Mg2+ binding site [chemical binding]; other site 315730005059 G4 box; other site 315730005060 G5 box; other site 315730005061 Protein of unknown function (DUF3931); Region: DUF3931; pfam13082 315730005062 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 315730005063 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730005064 Coenzyme A binding pocket [chemical binding]; other site 315730005065 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 315730005066 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 315730005067 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 315730005068 active site residue [active] 315730005069 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 315730005070 active site residue [active] 315730005071 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 315730005072 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 315730005073 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 315730005074 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 315730005075 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 315730005076 5'-3' exonuclease; Region: 53EXOc; smart00475 315730005077 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 315730005078 active site 315730005079 metal binding site 1 [ion binding]; metal-binding site 315730005080 putative 5' ssDNA interaction site; other site 315730005081 metal binding site 3; metal-binding site 315730005082 metal binding site 2 [ion binding]; metal-binding site 315730005083 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 315730005084 putative DNA binding site [nucleotide binding]; other site 315730005085 putative metal binding site [ion binding]; other site 315730005086 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 315730005087 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 315730005088 catalytic triad [active] 315730005089 conserved cis-peptide bond; other site 315730005090 EamA-like transporter family; Region: EamA; cl01037 315730005091 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 315730005092 EamA-like transporter family; Region: EamA; cl01037 315730005093 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 315730005094 RNA/DNA hybrid binding site [nucleotide binding]; other site 315730005095 active site 315730005096 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 315730005097 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 315730005098 active site 315730005099 catalytic residues [active] 315730005100 QueT transporter; Region: QueT; cl01932 315730005101 hypothetical protein; Validated; Region: PRK07708 315730005102 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 315730005103 RNA/DNA hybrid binding site [nucleotide binding]; other site 315730005104 active site 315730005105 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 315730005106 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 315730005107 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 315730005108 DNA-binding site [nucleotide binding]; DNA binding site 315730005109 RNA-binding motif; other site 315730005110 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 315730005111 LysE type translocator; Region: LysE; cl00565 315730005112 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 315730005113 Protein of unknown function, DUF485; Region: DUF485; cl01231 315730005114 Sodium:solute symporter family; Region: SSF; cl00456 315730005115 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 315730005116 aminotransferase; Validated; Region: PRK07678 315730005117 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315730005118 inhibitor-cofactor binding pocket; inhibition site 315730005119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730005120 catalytic residue [active] 315730005121 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 315730005122 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 315730005123 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 315730005124 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 315730005125 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315730005126 DNA binding residues [nucleotide binding] 315730005127 drug binding residues [chemical binding]; other site 315730005128 dimer interface [polypeptide binding]; other site 315730005129 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 315730005130 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 315730005131 MatE; Region: MatE; cl10513 315730005132 MatE; Region: MatE; cl10513 315730005133 Protein of unknown function (DUF421); Region: DUF421; cl00990 315730005134 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 315730005135 putative active site [active] 315730005136 Tic20-like protein; Region: Tic20; pfam09685 315730005137 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 315730005138 dimer interface [polypeptide binding]; other site 315730005139 FMN binding site [chemical binding]; other site 315730005140 NADPH bind site [chemical binding]; other site 315730005141 RNA polymerase factor sigma-70; Validated; Region: PRK06811 315730005142 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730005143 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 315730005144 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 315730005145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730005146 H+ Antiporter protein; Region: 2A0121; TIGR00900 315730005147 putative substrate translocation pore; other site 315730005148 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730005149 dimerization interface [polypeptide binding]; other site 315730005150 putative DNA binding site [nucleotide binding]; other site 315730005151 putative Zn2+ binding site [ion binding]; other site 315730005152 H+ Antiporter protein; Region: 2A0121; TIGR00900 315730005153 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730005154 putative substrate translocation pore; other site 315730005155 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 315730005156 active site 315730005157 metal binding site [ion binding]; metal-binding site 315730005158 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730005159 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 315730005160 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 315730005161 Sm1 motif; other site 315730005162 D3 - B interaction site; other site 315730005163 D1 - D2 interaction site; other site 315730005164 Hfq - Hfq interaction site; other site 315730005165 RNA binding pocket [nucleotide binding]; other site 315730005166 Sm2 motif; other site 315730005167 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 315730005168 flagellar motor protein MotP; Reviewed; Region: PRK06926 315730005169 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 315730005170 flagellar motor protein MotS; Reviewed; Region: PRK06742 315730005171 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 315730005172 ligand binding site [chemical binding]; other site 315730005173 Response regulator receiver domain; Region: Response_reg; pfam00072 315730005174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730005175 active site 315730005176 phosphorylation site [posttranslational modification] 315730005177 intermolecular recognition site; other site 315730005178 dimerization interface [polypeptide binding]; other site 315730005179 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 315730005180 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 315730005181 putative binding surface; other site 315730005182 active site 315730005183 P2 response regulator binding domain; Region: P2; pfam07194 315730005184 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 315730005185 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730005186 ATP binding site [chemical binding]; other site 315730005187 Mg2+ binding site [ion binding]; other site 315730005188 G-X-G motif; other site 315730005189 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 315730005190 flagellar motor switch protein; Reviewed; Region: PRK06782 315730005191 Chemotaxis phosphatase CheX; Region: CheX; cl15816 315730005192 Chemotaxis phosphatase CheX; Region: CheX; cl15816 315730005193 Chemotaxis phosphatase CheX; Region: CheX; cl15816 315730005194 Chemotaxis phosphatase CheX; Region: CheX; cl15816 315730005195 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 315730005196 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 315730005197 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 315730005198 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730005199 Protein of unknown function (DUF327); Region: DUF327; cl00753 315730005200 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 315730005201 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 315730005202 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 315730005203 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 315730005204 flagellar capping protein; Validated; Region: fliD; PRK06798 315730005205 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 315730005206 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 315730005207 Flagellar protein FliS; Region: FliS; cl00654 315730005208 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 315730005209 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 315730005210 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 315730005211 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 315730005212 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 315730005213 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 315730005214 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 315730005215 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 315730005216 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 315730005217 FliG C-terminal domain; Region: FliG_C; pfam01706 315730005218 flagellar assembly protein H; Validated; Region: fliH; PRK06800 315730005219 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 315730005220 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730005221 Walker A motif; other site 315730005222 ATP binding site [chemical binding]; other site 315730005223 Walker B motif; other site 315730005224 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 315730005225 flagellar basal body rod modification protein; Validated; Region: flgD; PRK06792 315730005226 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 315730005227 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 315730005228 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 315730005229 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 315730005230 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 315730005231 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 315730005232 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 315730005233 putative CheA interaction surface; other site 315730005234 Response regulator receiver domain; Region: Response_reg; pfam00072 315730005235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730005236 active site 315730005237 phosphorylation site [posttranslational modification] 315730005238 intermolecular recognition site; other site 315730005239 dimerization interface [polypeptide binding]; other site 315730005240 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 315730005241 S-layer homology domain; Region: SLH; pfam00395 315730005242 S-layer homology domain; Region: SLH; pfam00395 315730005243 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 315730005244 active site 315730005245 metal binding site [ion binding]; metal-binding site 315730005246 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 315730005247 PAS fold; Region: PAS_4; pfam08448 315730005248 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315730005249 putative active site [active] 315730005250 heme pocket [chemical binding]; other site 315730005251 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 315730005252 metal binding site [ion binding]; metal-binding site 315730005253 active site 315730005254 I-site; other site 315730005255 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 315730005256 Integral membrane protein TerC family; Region: TerC; cl10468 315730005257 flagellin; Provisional; Region: PRK12808 315730005258 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 315730005259 flagellin; Provisional; Region: PRK12807 315730005260 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 315730005261 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 315730005262 flagellin; Provisional; Region: PRK12807 315730005263 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 315730005264 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 315730005265 flagellin; Provisional; Region: PRK12807 315730005266 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 315730005267 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 315730005268 Protein of Unknown function (DUF1690); Region: DUF1690; pfam07956 315730005269 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 315730005270 N-acetyl-D-glucosamine binding site [chemical binding]; other site 315730005271 catalytic residue [active] 315730005272 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 315730005273 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 315730005274 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 315730005275 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 315730005276 FliP family; Region: FliP; cl00593 315730005277 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 315730005278 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 315730005279 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 315730005280 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 315730005281 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 315730005282 FHIPEP family; Region: FHIPEP; pfam00771 315730005283 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK11889 315730005284 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730005285 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 315730005286 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 315730005287 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 315730005288 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 315730005289 active site 315730005290 non-prolyl cis peptide bond; other site 315730005291 Predicted transcriptional regulators [Transcription]; Region: COG1378 315730005292 Helix-turn-helix domains; Region: HTH; cl00088 315730005293 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 315730005294 C-terminal domain interface [polypeptide binding]; other site 315730005295 sugar binding site [chemical binding]; other site 315730005296 AzlC protein; Region: AzlC; cl00570 315730005297 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 315730005298 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 315730005299 VanZ like family; Region: VanZ; cl01971 315730005300 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 315730005301 Small acid-soluble spore protein H family; Region: SspH; cl06949 315730005302 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730005303 non-specific DNA binding site [nucleotide binding]; other site 315730005304 salt bridge; other site 315730005305 sequence-specific DNA binding site [nucleotide binding]; other site 315730005306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730005307 H+ Antiporter protein; Region: 2A0121; TIGR00900 315730005308 putative substrate translocation pore; other site 315730005309 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 315730005310 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 315730005311 Helix-turn-helix domains; Region: HTH; cl00088 315730005312 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315730005313 dimerization interface [polypeptide binding]; other site 315730005314 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 315730005315 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730005316 Walker A/P-loop; other site 315730005317 ATP binding site [chemical binding]; other site 315730005318 Q-loop/lid; other site 315730005319 ABC transporter signature motif; other site 315730005320 Walker B; other site 315730005321 D-loop; other site 315730005322 H-loop/switch region; other site 315730005323 TOBE domain; Region: TOBE_2; cl01440 315730005324 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 315730005325 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 315730005326 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 315730005327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730005328 dimer interface [polypeptide binding]; other site 315730005329 conserved gate region; other site 315730005330 putative PBP binding loops; other site 315730005331 ABC-ATPase subunit interface; other site 315730005332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730005333 dimer interface [polypeptide binding]; other site 315730005334 conserved gate region; other site 315730005335 putative PBP binding loops; other site 315730005336 ABC-ATPase subunit interface; other site 315730005337 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 315730005338 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315730005339 Beta-Casp domain; Region: Beta-Casp; cl12567 315730005340 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 315730005341 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 315730005342 Cupin domain; Region: Cupin_2; cl09118 315730005343 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730005344 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 315730005345 catalytic core [active] 315730005346 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730005347 hypothetical protein; Provisional; Region: PRK09272 315730005348 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315730005349 Helix-turn-helix domains; Region: HTH; cl00088 315730005350 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 315730005351 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 315730005352 active site 315730005353 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 315730005354 dimer interface [polypeptide binding]; other site 315730005355 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 315730005356 Ligand Binding Site [chemical binding]; other site 315730005357 Molecular Tunnel; other site 315730005358 RNA polymerase factor sigma-70; Validated; Region: PRK06811 315730005359 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730005360 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730005361 DNA binding residues [nucleotide binding] 315730005362 VPS10 domain; Region: VPS10; smart00602 315730005363 VPS10 domain; Region: VPS10; smart00602 315730005364 Cation efflux family; Region: Cation_efflux; cl00316 315730005365 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 315730005366 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 315730005367 Transcriptional regulators [Transcription]; Region: GntR; COG1802 315730005368 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730005369 DNA-binding site [nucleotide binding]; DNA binding site 315730005370 FCD domain; Region: FCD; cl11656 315730005371 EamA-like transporter family; Region: EamA; cl01037 315730005372 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 315730005373 EamA-like transporter family; Region: EamA; cl01037 315730005374 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730005375 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 315730005376 fumarate hydratase; Reviewed; Region: fumC; PRK00485 315730005377 Class II fumarases; Region: Fumarase_classII; cd01362 315730005378 active site 315730005379 tetramer interface [polypeptide binding]; other site 315730005380 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 315730005381 FAD binding domain; Region: FAD_binding_4; pfam01565 315730005382 Berberine and berberine like; Region: BBE; pfam08031 315730005383 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 315730005384 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 315730005385 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 315730005386 MatE; Region: MatE; cl10513 315730005387 MatE; Region: MatE; cl10513 315730005388 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 315730005389 active site pocket [active] 315730005390 oxyanion hole [active] 315730005391 catalytic triad [active] 315730005392 active site nucleophile [active] 315730005393 Protein of unknown function (DUF3942); Region: DUF3942; pfam13078 315730005394 Helix-turn-helix domains; Region: HTH; cl00088 315730005395 BlaR1 peptidase M56; Region: Peptidase_M56; cl15829 315730005396 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 315730005397 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 315730005398 catalytic residues [active] 315730005399 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 315730005400 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 315730005401 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730005402 non-specific DNA binding site [nucleotide binding]; other site 315730005403 salt bridge; other site 315730005404 sequence-specific DNA binding site [nucleotide binding]; other site 315730005405 Cupin domain; Region: Cupin_2; cl09118 315730005406 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 315730005407 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 315730005408 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 315730005409 catalytic residue [active] 315730005410 Protein of unknown function (DUF445); Region: DUF445; pfam04286 315730005411 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730005412 RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642 315730005413 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730005414 DNA binding residues [nucleotide binding] 315730005415 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 315730005416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730005417 active site 315730005418 phosphorylation site [posttranslational modification] 315730005419 intermolecular recognition site; other site 315730005420 dimerization interface [polypeptide binding]; other site 315730005421 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 315730005422 DNA binding residues [nucleotide binding] 315730005423 dimerization interface [polypeptide binding]; other site 315730005424 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 315730005425 Histidine kinase; Region: HisKA_3; pfam07730 315730005426 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730005427 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 315730005428 Walker A/P-loop; other site 315730005429 ATP binding site [chemical binding]; other site 315730005430 Q-loop/lid; other site 315730005431 ABC transporter signature motif; other site 315730005432 Walker B; other site 315730005433 D-loop; other site 315730005434 H-loop/switch region; other site 315730005435 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 315730005436 ABC-2 type transporter; Region: ABC2_membrane; cl11417 315730005437 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 315730005438 ABC-2 type transporter; Region: ABC2_membrane; cl11417 315730005439 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315730005440 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 315730005441 putative active site [active] 315730005442 catalytic site [active] 315730005443 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 315730005444 PLD-like domain; Region: PLDc_2; pfam13091 315730005445 putative active site [active] 315730005446 catalytic site [active] 315730005447 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 315730005448 putative nucleotide binding site [chemical binding]; other site 315730005449 uridine monophosphate binding site [chemical binding]; other site 315730005450 homohexameric interface [polypeptide binding]; other site 315730005451 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 315730005452 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 315730005453 aspartate ammonia-lyase; Provisional; Region: PRK14515 315730005454 Aspartase; Region: Aspartase; cd01357 315730005455 active sites [active] 315730005456 tetramer interface [polypeptide binding]; other site 315730005457 malate dehydrogenase; Provisional; Region: PRK13529 315730005458 Malic enzyme, N-terminal domain; Region: malic; pfam00390 315730005459 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 315730005460 NAD(P) binding site [chemical binding]; other site 315730005461 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730005462 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730005463 ATP binding site [chemical binding]; other site 315730005464 Mg2+ binding site [ion binding]; other site 315730005465 G-X-G motif; other site 315730005466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730005467 Response regulator receiver domain; Region: Response_reg; pfam00072 315730005468 active site 315730005469 phosphorylation site [posttranslational modification] 315730005470 intermolecular recognition site; other site 315730005471 dimerization interface [polypeptide binding]; other site 315730005472 YcbB domain; Region: YcbB; pfam08664 315730005473 Uncharacterized conserved protein [Function unknown]; Region: COG4715 315730005474 SWIM zinc finger; Region: SWIM; cl15408 315730005475 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 315730005476 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 315730005477 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315730005478 ATP binding site [chemical binding]; other site 315730005479 putative Mg++ binding site [ion binding]; other site 315730005480 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315730005481 nucleotide binding region [chemical binding]; other site 315730005482 ATP-binding site [chemical binding]; other site 315730005483 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 315730005484 dimer interface [polypeptide binding]; other site 315730005485 active site 315730005486 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 315730005487 putative dimer interface [polypeptide binding]; other site 315730005488 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730005489 aspartate kinase; Reviewed; Region: PRK06635 315730005490 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 315730005491 putative nucleotide binding site [chemical binding]; other site 315730005492 putative catalytic residues [active] 315730005493 putative Mg ion binding site [ion binding]; other site 315730005494 putative aspartate binding site [chemical binding]; other site 315730005495 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 315730005496 putative allosteric regulatory site; other site 315730005497 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 315730005498 putative allosteric regulatory residue; other site 315730005499 DoxX-like family; Region: DoxX_3; pfam13781 315730005500 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 315730005501 YndJ-like protein; Region: YndJ; pfam14158 315730005502 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 315730005503 putative active site [active] 315730005504 nucleotide binding site [chemical binding]; other site 315730005505 nudix motif; other site 315730005506 putative metal binding site [ion binding]; other site 315730005507 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730005508 active site 315730005509 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 315730005510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730005511 putative substrate translocation pore; other site 315730005512 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 315730005513 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 315730005514 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 315730005515 HflX GTPase family; Region: HflX; cd01878 315730005516 G1 box; other site 315730005517 GTP/Mg2+ binding site [chemical binding]; other site 315730005518 Switch I region; other site 315730005519 G2 box; other site 315730005520 G3 box; other site 315730005521 Switch II region; other site 315730005522 G4 box; other site 315730005523 G5 box; other site 315730005524 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730005525 putative substrate translocation pore; other site 315730005526 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 315730005527 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 315730005528 dimer interface [polypeptide binding]; other site 315730005529 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730005530 catalytic residue [active] 315730005531 Predicted acetyltransferase [General function prediction only]; Region: COG3981 315730005532 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730005533 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 315730005534 MatE; Region: MatE; cl10513 315730005535 stage V sporulation protein B; Region: spore_V_B; TIGR02900 315730005536 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 315730005537 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 315730005538 NodB motif; other site 315730005539 putative active site [active] 315730005540 putative catalytic site [active] 315730005541 putative Zn binding site [ion binding]; other site 315730005542 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 315730005543 Protein of unknown function (DUF421); Region: DUF421; cl00990 315730005544 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 315730005545 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 315730005546 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 315730005547 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 315730005548 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 315730005549 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 315730005550 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 315730005551 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 315730005552 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 315730005553 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 315730005554 NADP binding site [chemical binding]; other site 315730005555 homodimer interface [polypeptide binding]; other site 315730005556 active site 315730005557 substrate binding site [chemical binding]; other site 315730005558 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 315730005559 homodimer interface [polypeptide binding]; other site 315730005560 substrate-cofactor binding pocket; other site 315730005561 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730005562 catalytic residue [active] 315730005563 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06725 315730005564 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 315730005565 PYR/PP interface [polypeptide binding]; other site 315730005566 dimer interface [polypeptide binding]; other site 315730005567 TPP binding site [chemical binding]; other site 315730005568 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 315730005569 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 315730005570 TPP-binding site [chemical binding]; other site 315730005571 dimer interface [polypeptide binding]; other site 315730005572 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 315730005573 putative valine binding site [chemical binding]; other site 315730005574 dimer interface [polypeptide binding]; other site 315730005575 ketol-acid reductoisomerase; Provisional; Region: PRK05479 315730005576 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730005577 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 315730005578 Dehydratase family; Region: ILVD_EDD; cl00340 315730005579 threonine dehydratase; Validated; Region: PRK08639 315730005580 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 315730005581 tetramer interface [polypeptide binding]; other site 315730005582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730005583 catalytic residue [active] 315730005584 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 315730005585 putative Ile/Val binding site [chemical binding]; other site 315730005586 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 315730005587 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 315730005588 putative active site [active] 315730005589 putative metal binding site [ion binding]; other site 315730005590 Protein of unknown function (DUF554); Region: DUF554; cl00784 315730005591 Clp protease ATP binding subunit; Region: clpC; CHL00095 315730005592 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730005593 drug efflux system protein MdtG; Provisional; Region: PRK09874 315730005594 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730005595 putative substrate translocation pore; other site 315730005596 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 315730005597 putative active site [active] 315730005598 metal binding site [ion binding]; metal-binding site 315730005599 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 315730005600 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315730005601 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 315730005602 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 315730005603 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 315730005604 5-methylthioadenosine/S-adenosylhomocysteine deaminase; Provisional; Region: PRK15493 315730005605 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 315730005606 active site 315730005607 putative substrate binding pocket [chemical binding]; other site 315730005608 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 315730005609 active site 315730005610 metal binding site [ion binding]; metal-binding site 315730005611 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 315730005612 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 315730005613 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 315730005614 peptide binding site [polypeptide binding]; other site 315730005615 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 315730005616 hypothetical protein; Provisional; Region: PRK06922 315730005617 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730005618 S-adenosylmethionine binding site [chemical binding]; other site 315730005619 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730005620 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730005621 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 315730005622 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 315730005623 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 315730005624 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 315730005625 active site residue [active] 315730005626 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 315730005627 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 315730005628 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730005629 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 315730005630 Amino acid permease; Region: AA_permease_2; pfam13520 315730005631 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 315730005632 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 315730005633 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 315730005634 LysE type translocator; Region: LysE; cl00565 315730005635 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 315730005636 active site 315730005637 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 315730005638 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730005639 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730005640 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 315730005641 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 315730005642 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 315730005643 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 315730005644 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 315730005645 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 315730005646 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 315730005647 intersubunit interface [polypeptide binding]; other site 315730005648 active site 315730005649 catalytic residue [active] 315730005650 nucleoside transporter; Region: nupC; TIGR00804 315730005651 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 315730005652 Nucleoside recognition; Region: Gate; cl00486 315730005653 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 315730005654 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 315730005655 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 315730005656 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 315730005657 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 315730005658 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 315730005659 active site 315730005660 catalytic motif [active] 315730005661 Zn binding site [ion binding]; other site 315730005662 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 315730005663 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 315730005664 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 315730005665 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315730005666 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730005667 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315730005668 Helix-turn-helix domains; Region: HTH; cl00088 315730005669 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315730005670 dimerization interface [polypeptide binding]; other site 315730005671 VPS10 domain; Region: VPS10; smart00602 315730005672 proline aminopeptidase P II; Provisional; Region: PRK10879 315730005673 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 315730005674 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 315730005675 active site 315730005676 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 315730005677 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 315730005678 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 315730005679 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 315730005680 DNA topoisomerase III; Provisional; Region: PRK07726 315730005681 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 315730005682 active site 315730005683 putative interdomain interaction site [polypeptide binding]; other site 315730005684 putative metal-binding site [ion binding]; other site 315730005685 putative nucleotide binding site [chemical binding]; other site 315730005686 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 315730005687 domain I; other site 315730005688 DNA binding groove [nucleotide binding] 315730005689 phosphate binding site [ion binding]; other site 315730005690 domain II; other site 315730005691 domain III; other site 315730005692 nucleotide binding site [chemical binding]; other site 315730005693 catalytic site [active] 315730005694 domain IV; other site 315730005695 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 315730005696 Predicted membrane protein [Function unknown]; Region: COG2364 315730005697 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315730005698 Helix-turn-helix domains; Region: HTH; cl00088 315730005699 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315730005700 dimerization interface [polypeptide binding]; other site 315730005701 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 315730005702 Membrane transport protein; Region: Mem_trans; cl09117 315730005703 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 315730005704 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 315730005705 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730005706 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 315730005707 dimer interface [polypeptide binding]; other site 315730005708 substrate binding site [chemical binding]; other site 315730005709 metal binding site [ion binding]; metal-binding site 315730005710 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 315730005711 Amidinotransferase; Region: Amidinotransf; cl12043 315730005712 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 315730005713 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 315730005714 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730005715 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 315730005716 Fatty acid desaturase; Region: FA_desaturase; pfam00487 315730005717 putative di-iron ligands [ion binding]; other site 315730005718 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 315730005719 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 315730005720 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315730005721 peptide synthase; Provisional; Region: PRK12316 315730005722 AMP-binding enzyme; Region: AMP-binding; cl15778 315730005723 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315730005724 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 315730005725 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315730005726 AMP-binding enzyme; Region: AMP-binding; cl15778 315730005727 acetoacetyl-CoA synthase; Region: ac_ac_CoA_syn; TIGR01217 315730005728 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315730005729 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 315730005730 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 315730005731 active site 315730005732 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 315730005733 Acyl transferase domain; Region: Acyl_transf_1; cl08282 315730005734 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315730005735 thioester reductase domain; Region: Thioester-redct; TIGR01746 315730005736 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 315730005737 putative NAD(P) binding site [chemical binding]; other site 315730005738 active site 315730005739 putative substrate binding site [chemical binding]; other site 315730005740 peptide synthase; Provisional; Region: PRK12316 315730005741 AMP-binding enzyme; Region: AMP-binding; cl15778 315730005742 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315730005743 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 315730005744 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730005745 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 315730005746 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730005747 Walker A/P-loop; other site 315730005748 ATP binding site [chemical binding]; other site 315730005749 ABC transporter signature motif; other site 315730005750 Walker B; other site 315730005751 D-loop; other site 315730005752 H-loop/switch region; other site 315730005753 peptide synthase; Provisional; Region: PRK12316 315730005754 AMP-binding enzyme; Region: AMP-binding; cl15778 315730005755 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315730005756 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 315730005757 AMP-binding enzyme; Region: AMP-binding; cl15778 315730005758 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315730005759 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315730005760 AMP-binding enzyme; Region: AMP-binding; cl15778 315730005761 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315730005762 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315730005763 Bacterial Ig-like domain; Region: Big_5; cl01012 315730005764 Copper resistance protein D; Region: CopD; cl00563 315730005765 FixH; Region: FixH; cl01254 315730005766 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 315730005767 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730005768 EamA-like transporter family; Region: EamA; cl01037 315730005769 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 315730005770 EamA-like transporter family; Region: EamA; cl01037 315730005771 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315730005772 Helix-turn-helix domains; Region: HTH; cl00088 315730005773 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315730005774 dimerization interface [polypeptide binding]; other site 315730005775 Predicted transcriptional regulator [Transcription]; Region: COG1959 315730005776 Helix-turn-helix domains; Region: HTH; cl00088 315730005777 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 315730005778 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 315730005779 catalytic residues [active] 315730005780 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 315730005781 dimer interface [polypeptide binding]; other site 315730005782 FMN binding site [chemical binding]; other site 315730005783 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730005784 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 315730005785 Coenzyme A binding pocket [chemical binding]; other site 315730005786 amidase; Provisional; Region: PRK06707 315730005787 Amidase; Region: Amidase; cl11426 315730005788 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 315730005789 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 315730005790 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 315730005791 tetramer (dimer of dimers) interface [polypeptide binding]; other site 315730005792 NAD binding site [chemical binding]; other site 315730005793 dimer interface [polypeptide binding]; other site 315730005794 substrate binding site [chemical binding]; other site 315730005795 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 315730005796 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730005797 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 315730005798 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730005799 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 315730005800 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 315730005801 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 315730005802 putative ligand binding site [chemical binding]; other site 315730005803 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 315730005804 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 315730005805 Walker A/P-loop; other site 315730005806 ATP binding site [chemical binding]; other site 315730005807 Q-loop/lid; other site 315730005808 ABC transporter signature motif; other site 315730005809 Walker B; other site 315730005810 D-loop; other site 315730005811 H-loop/switch region; other site 315730005812 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 315730005813 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 315730005814 Walker A/P-loop; other site 315730005815 ATP binding site [chemical binding]; other site 315730005816 Q-loop/lid; other site 315730005817 ABC transporter signature motif; other site 315730005818 Walker B; other site 315730005819 D-loop; other site 315730005820 H-loop/switch region; other site 315730005821 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 315730005822 TM-ABC transporter signature motif; other site 315730005823 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 315730005824 TM-ABC transporter signature motif; other site 315730005825 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315730005826 Helix-turn-helix domains; Region: HTH; cl00088 315730005827 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 315730005828 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730005829 Zn binding site [ion binding]; other site 315730005830 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 315730005831 Zn binding site [ion binding]; other site 315730005832 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 315730005833 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 315730005834 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 315730005835 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 315730005836 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 315730005837 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 315730005838 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 315730005839 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 315730005840 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730005841 Walker A/P-loop; other site 315730005842 ATP binding site [chemical binding]; other site 315730005843 Q-loop/lid; other site 315730005844 ABC transporter signature motif; other site 315730005845 Walker B; other site 315730005846 D-loop; other site 315730005847 H-loop/switch region; other site 315730005848 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 315730005849 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 315730005850 The CYD subfamily implicated in cytochrome bd biogenesis. The CydC and CydD proteins are important for the formation of cytochrome bd terminal oxidase of E. coli and it has been proposed that they were necessary for biosynthesis of the cytochrome bd...; Region: ABCC_cytochrome_bd; cd03247 315730005851 Walker A/P-loop; other site 315730005852 ATP binding site [chemical binding]; other site 315730005853 Q-loop/lid; other site 315730005854 ABC transporter signature motif; other site 315730005855 Walker B; other site 315730005856 D-loop; other site 315730005857 H-loop/switch region; other site 315730005858 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 315730005859 putative dimer interface [polypeptide binding]; other site 315730005860 catalytic triad [active] 315730005861 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 315730005862 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730005863 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 315730005864 dimer interface [polypeptide binding]; other site 315730005865 FMN binding site [chemical binding]; other site 315730005866 Bacterial SH3 domain; Region: SH3_3; cl02551 315730005867 Bacterial SH3 domain; Region: SH3_3; cl02551 315730005868 Bacterial SH3 domain; Region: SH3_3; cl02551 315730005869 NlpC/P60 family; Region: NLPC_P60; cl11438 315730005870 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730005871 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 315730005872 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 315730005873 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730005874 Walker A/P-loop; other site 315730005875 ATP binding site [chemical binding]; other site 315730005876 Q-loop/lid; other site 315730005877 ABC transporter signature motif; other site 315730005878 Walker B; other site 315730005879 D-loop; other site 315730005880 H-loop/switch region; other site 315730005881 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730005882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730005883 active site 315730005884 phosphorylation site [posttranslational modification] 315730005885 intermolecular recognition site; other site 315730005886 dimerization interface [polypeptide binding]; other site 315730005887 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730005888 DNA binding site [nucleotide binding] 315730005889 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730005890 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 315730005891 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730005892 dimer interface [polypeptide binding]; other site 315730005893 phosphorylation site [posttranslational modification] 315730005894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730005895 ATP binding site [chemical binding]; other site 315730005896 Mg2+ binding site [ion binding]; other site 315730005897 G-X-G motif; other site 315730005898 classical (c) SDRs; Region: SDR_c; cd05233 315730005899 NAD(P) binding site [chemical binding]; other site 315730005900 active site 315730005901 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 315730005902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730005903 S-adenosylmethionine binding site [chemical binding]; other site 315730005904 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 315730005905 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 315730005906 NodB motif; other site 315730005907 active site 315730005908 catalytic site [active] 315730005909 metal binding site [ion binding]; metal-binding site 315730005910 SdpI/YhfL protein family; Region: SdpI; pfam13630 315730005911 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 315730005912 nudix motif; other site 315730005913 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 315730005914 homoserine dehydrogenase; Provisional; Region: PRK06349 315730005915 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730005916 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 315730005917 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 315730005918 threonine synthase; Reviewed; Region: PRK06721 315730005919 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 315730005920 homodimer interface [polypeptide binding]; other site 315730005921 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730005922 catalytic residue [active] 315730005923 homoserine kinase; Provisional; Region: PRK01212 315730005924 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 315730005925 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 315730005926 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 315730005927 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 315730005928 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 315730005929 NodB motif; other site 315730005930 active site 315730005931 catalytic site [active] 315730005932 Zn binding site [ion binding]; other site 315730005933 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 315730005934 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 315730005935 MgtC family; Region: MgtC; pfam02308 315730005936 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 315730005937 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730005938 Coenzyme A binding pocket [chemical binding]; other site 315730005939 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 315730005940 IucA / IucC family; Region: IucA_IucC; pfam04183 315730005941 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 315730005942 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 315730005943 IucA / IucC family; Region: IucA_IucC; pfam04183 315730005944 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 315730005945 acyl-CoA synthetase; Validated; Region: PRK08308 315730005946 AMP-binding enzyme; Region: AMP-binding; cl15778 315730005947 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315730005948 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315730005949 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 315730005950 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 315730005951 Metal-binding active site; metal-binding site 315730005952 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 315730005953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730005954 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730005955 putative substrate translocation pore; other site 315730005956 LysE type translocator; Region: LysE; cl00565 315730005957 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 315730005958 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730005959 DNA-binding site [nucleotide binding]; DNA binding site 315730005960 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315730005961 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730005962 homodimer interface [polypeptide binding]; other site 315730005963 catalytic residue [active] 315730005964 Protein of unknown function (DUF3933); Region: DUF3933; pfam13069 315730005965 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 315730005966 active site 315730005967 nucleophile elbow; other site 315730005968 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 315730005969 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279 315730005970 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 315730005971 Domain of unknown function (DUF4083); Region: DUF4083; pfam13314 315730005972 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 315730005973 nudix motif; other site 315730005974 NAD+ synthetase; Region: nadE; TIGR00552 315730005975 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 315730005976 homodimer interface [polypeptide binding]; other site 315730005977 NAD binding pocket [chemical binding]; other site 315730005978 ATP binding pocket [chemical binding]; other site 315730005979 Mg binding site [ion binding]; other site 315730005980 active-site loop [active] 315730005981 FtsX-like permease family; Region: FtsX; cl15850 315730005982 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 315730005983 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 315730005984 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 315730005985 active site 315730005986 catalytic residues [active] 315730005987 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730005988 dimerization interface [polypeptide binding]; other site 315730005989 putative DNA binding site [nucleotide binding]; other site 315730005990 putative Zn2+ binding site [ion binding]; other site 315730005991 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 315730005992 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 315730005993 active site 315730005994 catalytic tetrad [active] 315730005995 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 315730005996 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 315730005997 DinB superfamily; Region: DinB_2; pfam12867 315730005998 GTPase RsgA; Reviewed; Region: PRK01889 315730005999 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 315730006000 RNA binding site [nucleotide binding]; other site 315730006001 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 315730006002 GTPase/Zn-binding domain interface [polypeptide binding]; other site 315730006003 GTP/Mg2+ binding site [chemical binding]; other site 315730006004 G4 box; other site 315730006005 G5 box; other site 315730006006 G1 box; other site 315730006007 Switch I region; other site 315730006008 G2 box; other site 315730006009 G3 box; other site 315730006010 Switch II region; other site 315730006011 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 315730006012 Cache domain; Region: Cache_1; pfam02743 315730006013 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 315730006014 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730006015 dimerization interface [polypeptide binding]; other site 315730006016 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315730006017 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315730006018 dimer interface [polypeptide binding]; other site 315730006019 putative CheW interface [polypeptide binding]; other site 315730006020 Protein of unknown function (DUF3979); Region: DUF3979; pfam13141 315730006021 Uncharacterized membrane protein [Function unknown]; Region: COG3949 315730006022 Ferritin-like domain; Region: Ferritin; pfam00210 315730006023 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 315730006024 dimerization interface [polypeptide binding]; other site 315730006025 DPS ferroxidase diiron center [ion binding]; other site 315730006026 ion pore; other site 315730006027 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 315730006028 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 315730006029 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 315730006030 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 315730006031 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 315730006032 Protein of unknown function (DUF3896); Region: DUF3896; pfam13035 315730006033 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 315730006034 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730006035 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315730006036 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730006037 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 315730006038 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 315730006039 active site 315730006040 catalytic tetrad [active] 315730006041 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 315730006042 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 315730006043 P-loop, Walker A motif; other site 315730006044 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 315730006045 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730006046 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 315730006047 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 315730006048 metal binding site [ion binding]; metal-binding site 315730006049 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 315730006050 NADH(P)-binding; Region: NAD_binding_10; pfam13460 315730006051 NAD binding site [chemical binding]; other site 315730006052 active site 315730006053 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 315730006054 active site 315730006055 FMN binding site [chemical binding]; other site 315730006056 substrate binding site [chemical binding]; other site 315730006057 homotetramer interface [polypeptide binding]; other site 315730006058 catalytic residue [active] 315730006059 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 315730006060 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 315730006061 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 315730006062 DNA binding site [nucleotide binding] 315730006063 active site 315730006064 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 315730006065 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 315730006066 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 315730006067 peptide binding site [polypeptide binding]; other site 315730006068 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730006069 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 315730006070 active site 315730006071 metal binding site [ion binding]; metal-binding site 315730006072 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730006073 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 315730006074 catalytic core [active] 315730006075 CotH protein; Region: CotH; pfam08757 315730006076 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 315730006077 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 315730006078 nudix motif; other site 315730006079 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 315730006080 MatE; Region: MatE; cl10513 315730006081 MviN-like protein; Region: MVIN; pfam03023 315730006082 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 315730006083 Predicted permease; Region: DUF318; pfam03773 315730006084 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 315730006085 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 315730006086 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 315730006087 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 315730006088 putative active site [active] 315730006089 catalytic site [active] 315730006090 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 315730006091 putative active site [active] 315730006092 catalytic site [active] 315730006093 Coat F domain; Region: Coat_F; cl15836 315730006094 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 315730006095 NADH(P)-binding; Region: NAD_binding_10; pfam13460 315730006096 NAD binding site [chemical binding]; other site 315730006097 substrate binding site [chemical binding]; other site 315730006098 putative active site [active] 315730006099 Protein of unknown function (DUF456); Region: DUF456; cl01069 315730006100 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 315730006101 Domain of unknown function DUF21; Region: DUF21; pfam01595 315730006102 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 315730006103 Transporter associated domain; Region: CorC_HlyC; cl08393 315730006104 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 315730006105 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 315730006106 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 315730006107 dimer interface [polypeptide binding]; other site 315730006108 putative tRNA-binding site [nucleotide binding]; other site 315730006109 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 315730006110 DinB superfamily; Region: DinB_2; pfam12867 315730006111 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 315730006112 stage II sporulation protein P; Region: spore_II_P; TIGR02867 315730006113 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730006114 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730006115 Coenzyme A binding pocket [chemical binding]; other site 315730006116 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730006117 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 315730006118 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 315730006119 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 315730006120 nudix motif; other site 315730006121 amidase; Provisional; Region: PRK06828 315730006122 Amidase; Region: Amidase; cl11426 315730006123 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 315730006124 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 315730006125 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 315730006126 stage II sporulation protein P; Region: spore_II_P; TIGR02867 315730006127 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 315730006128 catalytic core [active] 315730006129 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730006130 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 315730006131 active site 315730006132 motif I; other site 315730006133 motif II; other site 315730006134 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730006135 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315730006136 Helix-turn-helix domains; Region: HTH; cl00088 315730006137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730006138 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730006139 putative substrate translocation pore; other site 315730006140 DinB superfamily; Region: DinB_2; pfam12867 315730006141 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 315730006142 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 315730006143 alanine racemase; Reviewed; Region: alr; PRK00053 315730006144 active site 315730006145 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 315730006146 dimer interface [polypeptide binding]; other site 315730006147 substrate binding site [chemical binding]; other site 315730006148 catalytic residues [active] 315730006149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730006150 S-adenosylmethionine binding site [chemical binding]; other site 315730006151 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730006152 Coenzyme A binding pocket [chemical binding]; other site 315730006153 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730006154 Coenzyme A binding pocket [chemical binding]; other site 315730006155 Phosphotransferase enzyme family; Region: APH; pfam01636 315730006156 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315730006157 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 315730006158 glycosyltransferase, MGT family; Region: MGT; TIGR01426 315730006159 active site 315730006160 TDP-binding site; other site 315730006161 acceptor substrate-binding pocket; other site 315730006162 homodimer interface [polypeptide binding]; other site 315730006163 Uncharacterized conserved protein [Function unknown]; Region: COG1284 315730006164 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315730006165 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 315730006166 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 315730006167 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730006168 DNA-binding site [nucleotide binding]; DNA binding site 315730006169 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315730006170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730006171 homodimer interface [polypeptide binding]; other site 315730006172 catalytic residue [active] 315730006173 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 315730006174 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730006175 Coenzyme A binding pocket [chemical binding]; other site 315730006176 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 315730006177 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 315730006178 active site 315730006179 metal binding site [ion binding]; metal-binding site 315730006180 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315730006181 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730006182 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730006183 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 315730006184 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 315730006185 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730006186 Coenzyme A binding pocket [chemical binding]; other site 315730006187 Cupin domain; Region: Cupin_2; cl09118 315730006188 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730006189 Coenzyme A binding pocket [chemical binding]; other site 315730006190 Predicted acetyltransferase [General function prediction only]; Region: COG3393 315730006191 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730006192 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 315730006193 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730006194 S-adenosylmethionine binding site [chemical binding]; other site 315730006195 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 315730006196 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 315730006197 Potassium binding sites [ion binding]; other site 315730006198 Cesium cation binding sites [ion binding]; other site 315730006199 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730006200 DEAD-like helicases superfamily; Region: DEXDc; smart00487 315730006201 ATP binding site [chemical binding]; other site 315730006202 putative Mg++ binding site [ion binding]; other site 315730006203 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315730006204 nucleotide binding region [chemical binding]; other site 315730006205 ATP-binding site [chemical binding]; other site 315730006206 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 315730006207 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 315730006208 NADP binding site [chemical binding]; other site 315730006209 dimer interface [polypeptide binding]; other site 315730006210 RNA polymerase sigma factor; Provisional; Region: PRK12543 315730006211 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730006212 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730006213 DNA binding residues [nucleotide binding] 315730006214 Domain of unknown function (DUF3600); Region: DUF3600; pfam12207 315730006215 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315730006216 Protein of unknown function (DUF3925); Region: DUF3925; pfam13063 315730006217 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 315730006218 catalytic residues [active] 315730006219 dimer interface [polypeptide binding]; other site 315730006220 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 315730006221 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 315730006222 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 315730006223 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 315730006224 MoxR-like ATPases [General function prediction only]; Region: COG0714 315730006225 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730006226 Walker A motif; other site 315730006227 ATP binding site [chemical binding]; other site 315730006228 Walker B motif; other site 315730006229 arginine finger; other site 315730006230 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 315730006231 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 315730006232 [4Fe-4S] binding site [ion binding]; other site 315730006233 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 315730006234 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 315730006235 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 315730006236 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 315730006237 molybdopterin cofactor binding site; other site 315730006238 nitrate reductase, beta subunit; Region: narH; TIGR01660 315730006239 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 315730006240 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 315730006241 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 315730006242 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 315730006243 ligand binding site [chemical binding]; other site 315730006244 flexible hinge region; other site 315730006245 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 315730006246 putative switch regulator; other site 315730006247 non-specific DNA interactions [nucleotide binding]; other site 315730006248 DNA binding site [nucleotide binding] 315730006249 sequence specific DNA binding site [nucleotide binding]; other site 315730006250 putative cAMP binding site [chemical binding]; other site 315730006251 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 315730006252 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315730006253 FeS/SAM binding site; other site 315730006254 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 315730006255 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 315730006256 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 315730006257 ATP binding site [chemical binding]; other site 315730006258 substrate interface [chemical binding]; other site 315730006259 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 315730006260 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 315730006261 dimer interface [polypeptide binding]; other site 315730006262 putative functional site; other site 315730006263 putative MPT binding site; other site 315730006264 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 315730006265 MoaE homodimer interface [polypeptide binding]; other site 315730006266 MoaD interaction [polypeptide binding]; other site 315730006267 active site residues [active] 315730006268 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 315730006269 MoaE interaction surface [polypeptide binding]; other site 315730006270 MoeB interaction surface [polypeptide binding]; other site 315730006271 thiocarboxylated glycine; other site 315730006272 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 315730006273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730006274 putative substrate translocation pore; other site 315730006275 PspC domain; Region: PspC; cl00864 315730006276 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 315730006277 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 315730006278 active site 315730006279 Membrane transport protein; Region: Mem_trans; cl09117 315730006280 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730006281 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 315730006282 putative active site [active] 315730006283 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 315730006284 putative active site [active] 315730006285 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 315730006286 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 315730006287 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 315730006288 [2Fe-2S] cluster binding site [ion binding]; other site 315730006289 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 315730006290 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315730006291 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 315730006292 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 315730006293 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 315730006294 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 315730006295 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 315730006296 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 315730006297 Excalibur calcium-binding domain; Region: Excalibur; cl05460 315730006298 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315730006299 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315730006300 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 315730006301 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 315730006302 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 315730006303 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 315730006304 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730006305 Walker A/P-loop; other site 315730006306 ATP binding site [chemical binding]; other site 315730006307 Q-loop/lid; other site 315730006308 ABC transporter signature motif; other site 315730006309 Walker B; other site 315730006310 D-loop; other site 315730006311 H-loop/switch region; other site 315730006312 ABC transporter; Region: ABC_tran_2; pfam12848 315730006313 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 315730006314 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 315730006315 Domain of unknown function (DUF4318); Region: DUF4318; pfam14201 315730006316 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 315730006317 dimer interface [polypeptide binding]; other site 315730006318 ssDNA binding site [nucleotide binding]; other site 315730006319 tetramer (dimer of dimers) interface [polypeptide binding]; other site 315730006320 Helix-turn-helix domains; Region: HTH; cl00088 315730006321 hypothetical protein; Provisional; Region: PRK06753 315730006322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730006323 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730006324 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 315730006325 Virulence factor; Region: Virulence_fact; pfam13769 315730006326 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 315730006327 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 315730006328 Protein of unknown function, DUF393; Region: DUF393; cl01136 315730006329 Disulphide isomerase; Region: Disulph_isomer; pfam06491 315730006330 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730006331 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 315730006332 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 315730006333 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 315730006334 active site 315730006335 HIGH motif; other site 315730006336 KMSK motif region; other site 315730006337 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 315730006338 tRNA binding surface [nucleotide binding]; other site 315730006339 anticodon binding site; other site 315730006340 Predicted membrane protein (DUF2085); Region: DUF2085; cl01570 315730006341 Methyltransferase domain; Region: Methyltransf_31; pfam13847 315730006342 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730006343 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 315730006344 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 315730006345 putative active site [active] 315730006346 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730006347 TPR motif; other site 315730006348 binding surface 315730006349 TPR repeat; Region: TPR_11; pfam13414 315730006350 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730006351 binding surface 315730006352 TPR motif; other site 315730006353 TPR repeat; Region: TPR_11; pfam13414 315730006354 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 315730006355 binding surface 315730006356 TPR motif; other site 315730006357 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 315730006358 binding surface 315730006359 TPR motif; other site 315730006360 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730006361 binding surface 315730006362 TPR motif; other site 315730006363 TPR repeat; Region: TPR_11; pfam13414 315730006364 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730006365 binding surface 315730006366 TPR motif; other site 315730006367 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730006368 binding surface 315730006369 Tetratricopeptide repeat; Region: TPR_16; pfam13432 315730006370 TPR motif; other site 315730006371 isoleucyl-tRNA synthetase; Region: ileS; TIGR00392 315730006372 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 315730006373 HIGH motif; other site 315730006374 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 315730006375 active site 315730006376 KMSKS motif; other site 315730006377 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 315730006378 tRNA binding surface [nucleotide binding]; other site 315730006379 anticodon binding site; other site 315730006380 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 315730006381 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 315730006382 Protein of unknown function (DUF418); Region: DUF418; cl12135 315730006383 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730006384 Helix-turn-helix domains; Region: HTH; cl00088 315730006385 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 315730006386 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 315730006387 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 315730006388 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 315730006389 Zn binding site [ion binding]; other site 315730006390 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 315730006391 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 315730006392 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 315730006393 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 315730006394 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 315730006395 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 315730006396 Dimer interface [polypeptide binding]; other site 315730006397 anticodon binding site; other site 315730006398 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 315730006399 homodimer interface [polypeptide binding]; other site 315730006400 motif 1; other site 315730006401 motif 2; other site 315730006402 active site 315730006403 motif 3; other site 315730006404 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 315730006405 metal ion-dependent adhesion site (MIDAS); other site 315730006406 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 315730006407 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 315730006408 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730006409 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730006410 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730006411 Proteins of 100 residues with WXG; Region: WXG100; cl02005 315730006412 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315730006413 active site 315730006414 ATP binding site [chemical binding]; other site 315730006415 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730006416 binding surface 315730006417 TPR motif; other site 315730006418 Tetratricopeptide repeat; Region: TPR_16; pfam13432 315730006419 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 315730006420 binding surface 315730006421 TPR motif; other site 315730006422 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730006423 binding surface 315730006424 TPR motif; other site 315730006425 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315730006426 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 315730006427 binding surface 315730006428 TPR motif; other site 315730006429 SseB protein; Region: SseB; cl06279 315730006430 Proteins of 100 residues with WXG; Region: WXG100; cl02005 315730006431 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 315730006432 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 315730006433 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 315730006434 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 315730006435 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 315730006436 catalytic residues [active] 315730006437 catalytic nucleophile [active] 315730006438 Recombinase; Region: Recombinase; pfam07508 315730006439 Transposase; Region: DEDD_Tnp_IS110; pfam01548 315730006440 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 315730006441 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 315730006442 helicase-primase subunit BBLF2/3; Provisional; Region: PHA03312 315730006443 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 315730006444 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 315730006445 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730006446 Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435 315730006447 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 315730006448 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 315730006449 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730006450 motif II; other site 315730006451 Citrate transporter; Region: CitMHS; pfam03600 315730006452 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 315730006453 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 315730006454 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 315730006455 putative active site [active] 315730006456 metal binding site [ion binding]; metal-binding site 315730006457 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 315730006458 aspartate racemase; Region: asp_race; TIGR00035 315730006459 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 315730006460 homodimer interaction site [polypeptide binding]; other site 315730006461 cofactor binding site; other site 315730006462 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 315730006463 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730006464 Coenzyme A binding pocket [chemical binding]; other site 315730006465 hypothetical protein; Validated; Region: PRK06769 315730006466 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730006467 active site 315730006468 motif I; other site 315730006469 motif II; other site 315730006470 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 315730006471 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 315730006472 Walker A/P-loop; other site 315730006473 ATP binding site [chemical binding]; other site 315730006474 Q-loop/lid; other site 315730006475 ABC transporter signature motif; other site 315730006476 Walker B; other site 315730006477 D-loop; other site 315730006478 H-loop/switch region; other site 315730006479 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 315730006480 YpjP-like protein; Region: YpjP; pfam14005 315730006481 Phosphotransferase enzyme family; Region: APH; pfam01636 315730006482 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 315730006483 active site 315730006484 substrate binding site [chemical binding]; other site 315730006485 ATP binding site [chemical binding]; other site 315730006486 Cupin domain; Region: Cupin_2; cl09118 315730006487 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 315730006488 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315730006489 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315730006490 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 315730006491 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315730006492 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730006493 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 315730006494 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 315730006495 dimerization interface [polypeptide binding]; other site 315730006496 active site 315730006497 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 315730006498 folate binding site [chemical binding]; other site 315730006499 NADP+ binding site [chemical binding]; other site 315730006500 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 315730006501 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315730006502 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 315730006503 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730006504 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 315730006505 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 315730006506 putative acyl-acceptor binding pocket; other site 315730006507 Haemolysin-III related; Region: HlyIII; cl03831 315730006508 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 315730006509 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 315730006510 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 315730006511 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 315730006512 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315730006513 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 315730006514 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 315730006515 Cu(I) binding site [ion binding]; other site 315730006516 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 315730006517 putative dimer interface [polypeptide binding]; other site 315730006518 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 315730006519 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 315730006520 active site 315730006521 dimer interface [polypeptide binding]; other site 315730006522 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 315730006523 Ligand Binding Site [chemical binding]; other site 315730006524 Molecular Tunnel; other site 315730006525 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730006526 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 315730006527 active site 315730006528 metal binding site [ion binding]; metal-binding site 315730006529 Bacterial SH3 domain; Region: SH3_3; cl02551 315730006530 Bacterial SH3 domain; Region: SH3_3; cl02551 315730006531 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 315730006532 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 315730006533 siderophore binding site; other site 315730006534 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 315730006535 homodimer interface [polypeptide binding]; other site 315730006536 substrate-cofactor binding pocket; other site 315730006537 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730006538 catalytic residue [active] 315730006539 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 315730006540 FMN binding site [chemical binding]; other site 315730006541 dimer interface [polypeptide binding]; other site 315730006542 Isochorismatase family; Region: Isochorismatase; pfam00857 315730006543 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 315730006544 catalytic triad [active] 315730006545 conserved cis-peptide bond; other site 315730006546 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 315730006547 nudix motif; other site 315730006548 Mechanosensitive ion channel; Region: MS_channel; pfam00924 315730006549 GAF domain; Region: GAF_2; pfam13185 315730006550 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 315730006551 Histidine kinase; Region: HisKA_3; pfam07730 315730006552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730006553 ATP binding site [chemical binding]; other site 315730006554 Mg2+ binding site [ion binding]; other site 315730006555 G-X-G motif; other site 315730006556 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 315730006557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730006558 active site 315730006559 phosphorylation site [posttranslational modification] 315730006560 intermolecular recognition site; other site 315730006561 dimerization interface [polypeptide binding]; other site 315730006562 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 315730006563 DNA binding residues [nucleotide binding] 315730006564 dimerization interface [polypeptide binding]; other site 315730006565 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 315730006566 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 315730006567 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 315730006568 putative active site [active] 315730006569 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 315730006570 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 315730006571 NAD binding site [chemical binding]; other site 315730006572 substrate binding site [chemical binding]; other site 315730006573 catalytic Zn binding site [ion binding]; other site 315730006574 tetramer interface [polypeptide binding]; other site 315730006575 structural Zn binding site [ion binding]; other site 315730006576 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 315730006577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730006578 dimer interface [polypeptide binding]; other site 315730006579 conserved gate region; other site 315730006580 ABC-ATPase subunit interface; other site 315730006581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 315730006582 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 315730006583 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 315730006584 N- and C-terminal domain interface [polypeptide binding]; other site 315730006585 putative active site [active] 315730006586 catalytic site [active] 315730006587 metal binding site [ion binding]; metal-binding site 315730006588 carbohydrate binding site [chemical binding]; other site 315730006589 ATP binding site [chemical binding]; other site 315730006590 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 315730006591 GntP family permease; Region: GntP_permease; pfam02447 315730006592 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 315730006593 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730006594 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 315730006595 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 315730006596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730006597 H+ Antiporter protein; Region: 2A0121; TIGR00900 315730006598 putative substrate translocation pore; other site 315730006599 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 315730006600 putative active site [active] 315730006601 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 315730006602 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 315730006603 Walker A/P-loop; other site 315730006604 ATP binding site [chemical binding]; other site 315730006605 Q-loop/lid; other site 315730006606 ABC transporter signature motif; other site 315730006607 Walker B; other site 315730006608 D-loop; other site 315730006609 H-loop/switch region; other site 315730006610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730006611 dimer interface [polypeptide binding]; other site 315730006612 conserved gate region; other site 315730006613 ABC-ATPase subunit interface; other site 315730006614 NMT1-like family; Region: NMT1_2; cl15260 315730006615 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 315730006616 arginine/ornithine antiporter; Region: arg_ornith_anti; TIGR03810 315730006617 Spore germination protein; Region: Spore_permease; cl15802 315730006618 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730006619 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 315730006620 Haemagglutinin; Region: Hemagglutinin; pfam00509 315730006621 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 315730006622 Domain of unknown function DUF21; Region: DUF21; pfam01595 315730006623 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 315730006624 Transporter associated domain; Region: CorC_HlyC; cl08393 315730006625 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 315730006626 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 315730006627 NAD(P) binding site [chemical binding]; other site 315730006628 catalytic residues [active] 315730006629 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 315730006630 Histidine kinase N terminal; Region: HisK_N; pfam09385 315730006631 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730006632 dimer interface [polypeptide binding]; other site 315730006633 phosphorylation site [posttranslational modification] 315730006634 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730006635 ATP binding site [chemical binding]; other site 315730006636 Mg2+ binding site [ion binding]; other site 315730006637 G-X-G motif; other site 315730006638 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 315730006639 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 315730006640 hypothetical protein; Provisional; Region: PRK06917 315730006641 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315730006642 inhibitor-cofactor binding pocket; inhibition site 315730006643 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730006644 catalytic residue [active] 315730006645 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 315730006646 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 315730006647 acetylornithine deacetylase; Validated; Region: PRK06915 315730006648 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 315730006649 metal binding site [ion binding]; metal-binding site 315730006650 dimer interface [polypeptide binding]; other site 315730006651 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 315730006652 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730006653 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 315730006654 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730006655 Walker A motif; other site 315730006656 ATP binding site [chemical binding]; other site 315730006657 Walker B motif; other site 315730006658 arginine finger; other site 315730006659 Helix-turn-helix domains; Region: HTH; cl00088 315730006660 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 315730006661 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315730006662 FeS/SAM binding site; other site 315730006663 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 315730006664 YokU-like protein; Region: YokU; cl15819 315730006665 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 315730006666 Protein of unknown function (DUF3930); Region: DUF3930; pfam13067 315730006667 YozD-like protein; Region: YozD; pfam14162 315730006668 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 315730006669 Catalytic domain of Protein Kinases; Region: PKc; cd00180 315730006670 active site 315730006671 ATP binding site [chemical binding]; other site 315730006672 substrate binding site [chemical binding]; other site 315730006673 activation loop (A-loop); other site 315730006674 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 315730006675 SpoOM protein; Region: Spo0M; pfam07070 315730006676 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 315730006677 active site 315730006678 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 315730006679 Cation efflux family; Region: Cation_efflux; cl00316 315730006680 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 315730006681 catalytic residues [active] 315730006682 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 315730006683 MepB protein; Region: MepB; cl01985 315730006684 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 315730006685 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 315730006686 active site 315730006687 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 315730006688 PPIC-type PPIASE domain; Region: Rotamase; cl08278 315730006689 YolD-like protein; Region: YolD; pfam08863 315730006690 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 315730006691 classical (c) SDRs; Region: SDR_c; cd05233 315730006692 NAD(P) binding site [chemical binding]; other site 315730006693 active site 315730006694 Proteolipid membrane potential modulator; Region: Pmp3; cl00431 315730006695 KTSC domain; Region: KTSC; pfam13619 315730006696 Transglycosylase; Region: Transgly; cl07896 315730006697 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 315730006698 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730006699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730006700 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730006701 putative substrate translocation pore; other site 315730006702 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 315730006703 dimer interface [polypeptide binding]; other site 315730006704 Citrate synthase; Region: Citrate_synt; pfam00285 315730006705 active site 315730006706 coenzyme A binding site [chemical binding]; other site 315730006707 citrylCoA binding site [chemical binding]; other site 315730006708 oxalacetate/citrate binding site [chemical binding]; other site 315730006709 catalytic triad [active] 315730006710 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 315730006711 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 315730006712 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 315730006713 tetramer interface [polypeptide binding]; other site 315730006714 active site 315730006715 Mg2+/Mn2+ binding site [ion binding]; other site 315730006716 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 315730006717 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 315730006718 active site 315730006719 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 315730006720 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730006721 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 315730006722 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 315730006723 tetrameric interface [polypeptide binding]; other site 315730006724 NAD binding site [chemical binding]; other site 315730006725 catalytic residues [active] 315730006726 LysE type translocator; Region: LysE; cl00565 315730006727 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 315730006728 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 315730006729 substrate binding site [chemical binding]; other site 315730006730 oxyanion hole (OAH) forming residues; other site 315730006731 trimer interface [polypeptide binding]; other site 315730006732 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 315730006733 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 315730006734 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 315730006735 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 315730006736 active site 315730006737 metal binding site [ion binding]; metal-binding site 315730006738 DNA binding site [nucleotide binding] 315730006739 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 315730006740 exonuclease SbcC; Region: sbcc; TIGR00618 315730006741 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 315730006742 Walker A/P-loop; other site 315730006743 ATP binding site [chemical binding]; other site 315730006744 Q-loop/lid; other site 315730006745 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 315730006746 ABC transporter signature motif; other site 315730006747 Walker B; other site 315730006748 D-loop; other site 315730006749 H-loop/switch region; other site 315730006750 Chitin binding domain; Region: Chitin_bind_3; cl03871 315730006751 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 315730006752 Interdomain contacts; other site 315730006753 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 315730006754 Interdomain contacts; other site 315730006755 Cytokine receptor motif; other site 315730006756 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 315730006757 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 315730006758 alanine racemase; Reviewed; Region: alr; PRK00053 315730006759 active site 315730006760 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 315730006761 dimer interface [polypeptide binding]; other site 315730006762 substrate binding site [chemical binding]; other site 315730006763 catalytic residues [active] 315730006764 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730006765 dimerization interface [polypeptide binding]; other site 315730006766 putative DNA binding site [nucleotide binding]; other site 315730006767 putative Zn2+ binding site [ion binding]; other site 315730006768 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 315730006769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730006770 putative substrate translocation pore; other site 315730006771 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 315730006772 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 315730006773 putative NAD(P) binding site [chemical binding]; other site 315730006774 active site 315730006775 isochorismate synthase DhbC; Validated; Region: PRK06923 315730006776 chorismate binding enzyme; Region: Chorismate_bind; cl10555 315730006777 2,3-dihydroxybenzoate-AMP ligase; Region: DHB_AMP_lig; TIGR02275 315730006778 AMP-binding enzyme; Region: AMP-binding; cl15778 315730006779 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315730006780 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 315730006781 hydrophobic substrate binding pocket; other site 315730006782 Isochorismatase family; Region: Isochorismatase; pfam00857 315730006783 active site 315730006784 conserved cis-peptide bond; other site 315730006785 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315730006786 peptide synthase; Provisional; Region: PRK12316 315730006787 AMP-binding enzyme; Region: AMP-binding; cl15778 315730006788 AMP-binding enzyme; Region: AMP-binding; cl15778 315730006789 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315730006790 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 315730006791 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 315730006792 AMP-binding enzyme; Region: AMP-binding; cl15778 315730006793 AMP-binding enzyme; Region: AMP-binding; cl15778 315730006794 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315730006795 MbtH-like protein; Region: MbtH; cl01279 315730006796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730006797 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730006798 putative substrate translocation pore; other site 315730006799 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 315730006800 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 315730006801 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 315730006802 IHF dimer interface [polypeptide binding]; other site 315730006803 IHF - DNA interface [nucleotide binding]; other site 315730006804 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 315730006805 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 315730006806 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 315730006807 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 315730006808 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 315730006809 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730006810 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 315730006811 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 315730006812 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315730006813 RNA binding surface [nucleotide binding]; other site 315730006814 PseudoU_synth_RluF_like: Pseudouridine synthase, Escherichia coli RluF like. This group is comprised of bacterial proteins similar to Escherichia coli RluF. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluF; cd02554 315730006815 probable active site [active] 315730006816 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 315730006817 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 315730006818 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 315730006819 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 315730006820 active site 315730006821 dimer interface [polypeptide binding]; other site 315730006822 motif 1; other site 315730006823 motif 2; other site 315730006824 motif 3; other site 315730006825 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 315730006826 anticodon binding site; other site 315730006827 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 315730006828 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 315730006829 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730006830 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 315730006831 Walker A/P-loop; other site 315730006832 ATP binding site [chemical binding]; other site 315730006833 Q-loop/lid; other site 315730006834 ABC transporter signature motif; other site 315730006835 Walker B; other site 315730006836 D-loop; other site 315730006837 H-loop/switch region; other site 315730006838 FtsX-like permease family; Region: FtsX; cl15850 315730006839 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 315730006840 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315730006841 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 315730006842 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 315730006843 pyruvate oxidase; Provisional; Region: PRK08611 315730006844 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 315730006845 PYR/PP interface [polypeptide binding]; other site 315730006846 tetramer interface [polypeptide binding]; other site 315730006847 dimer interface [polypeptide binding]; other site 315730006848 TPP binding site [chemical binding]; other site 315730006849 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 315730006850 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 315730006851 TPP-binding site [chemical binding]; other site 315730006852 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 315730006853 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 315730006854 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 315730006855 metal-binding site [ion binding] 315730006856 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 315730006857 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 315730006858 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730006859 dimerization interface [polypeptide binding]; other site 315730006860 putative DNA binding site [nucleotide binding]; other site 315730006861 putative Zn2+ binding site [ion binding]; other site 315730006862 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 315730006863 Domain of unknown function DUF21; Region: DUF21; pfam01595 315730006864 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 315730006865 Transporter associated domain; Region: CorC_HlyC; cl08393 315730006866 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315730006867 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 315730006868 active site 315730006869 dimerization interface [polypeptide binding]; other site 315730006870 Protein of unknown function (DUF2441); Region: DUF2441; pfam10386 315730006871 Protein of unknown function, DUF606; Region: DUF606; cl01273 315730006872 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 315730006873 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 315730006874 ligand binding site [chemical binding]; other site 315730006875 flexible hinge region; other site 315730006876 Helix-turn-helix domains; Region: HTH; cl00088 315730006877 Protein of unknown function, DUF606; Region: DUF606; cl01273 315730006878 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730006879 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730006880 Leucine carboxyl methyltransferase; Region: LCM; cl01306 315730006881 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315730006882 Helix-turn-helix domains; Region: HTH; cl00088 315730006883 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730006884 Coenzyme A binding pocket [chemical binding]; other site 315730006885 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315730006886 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730006887 Helix-turn-helix domains; Region: HTH; cl00088 315730006888 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 315730006889 Protein of unknown function (DUF4021); Region: DUF4021; pfam13213 315730006890 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 315730006891 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 315730006892 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730006893 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730006894 Coenzyme A binding pocket [chemical binding]; other site 315730006895 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 315730006896 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730006897 Coenzyme A binding pocket [chemical binding]; other site 315730006898 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 315730006899 putative acetyltransferase YhhY; Provisional; Region: PRK10140 315730006900 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730006901 Coenzyme A binding pocket [chemical binding]; other site 315730006902 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 315730006903 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 315730006904 EamA-like transporter family; Region: EamA; cl01037 315730006905 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 315730006906 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 315730006907 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730006908 non-specific DNA binding site [nucleotide binding]; other site 315730006909 salt bridge; other site 315730006910 sequence-specific DNA binding site [nucleotide binding]; other site 315730006911 Cupin domain; Region: Cupin_2; cl09118 315730006912 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 315730006913 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730006914 protoporphyrinogen oxidase; Provisional; Region: PRK12416 315730006915 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730006916 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730006917 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730006918 Cold-inducible protein YdjO; Region: YdjO; pfam14169 315730006919 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 315730006920 DNA-binding site [nucleotide binding]; DNA binding site 315730006921 RNA-binding motif; other site 315730006922 CAAX protease self-immunity; Region: Abi; cl00558 315730006923 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730006924 AAA domain; Region: AAA_18; pfam13238 315730006925 hypothetical protein; Provisional; Region: PRK06770 315730006926 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315730006927 Helix-turn-helix domains; Region: HTH; cl00088 315730006928 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315730006929 dimerization interface [polypeptide binding]; other site 315730006930 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06728 315730006931 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730006932 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 315730006933 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 315730006934 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 315730006935 Helix-turn-helix domains; Region: HTH; cl00088 315730006936 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315730006937 dimerization interface [polypeptide binding]; other site 315730006938 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 315730006939 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315730006940 inhibitor-cofactor binding pocket; inhibition site 315730006941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730006942 catalytic residue [active] 315730006943 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 315730006944 MOSC domain; Region: MOSC; pfam03473 315730006945 3-alpha domain; Region: 3-alpha; pfam03475 315730006946 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730006947 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 315730006948 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 315730006949 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 315730006950 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730006951 Walker A/P-loop; other site 315730006952 ATP binding site [chemical binding]; other site 315730006953 Q-loop/lid; other site 315730006954 ABC transporter signature motif; other site 315730006955 Walker B; other site 315730006956 D-loop; other site 315730006957 H-loop/switch region; other site 315730006958 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 315730006959 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 315730006960 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730006961 Walker A/P-loop; other site 315730006962 ATP binding site [chemical binding]; other site 315730006963 Q-loop/lid; other site 315730006964 ABC transporter signature motif; other site 315730006965 Walker B; other site 315730006966 D-loop; other site 315730006967 H-loop/switch region; other site 315730006968 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 315730006969 LysE type translocator; Region: LysE; cl00565 315730006970 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 315730006971 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730006972 non-specific DNA binding site [nucleotide binding]; other site 315730006973 salt bridge; other site 315730006974 sequence-specific DNA binding site [nucleotide binding]; other site 315730006975 Cupin domain; Region: Cupin_2; cl09118 315730006976 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 315730006977 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 315730006978 BclB C-terminal domain; Region: exospore_TM; TIGR03721 315730006979 Cupin domain; Region: Cupin_2; cl09118 315730006980 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 315730006981 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 315730006982 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 315730006983 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 315730006984 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730006985 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 315730006986 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730006987 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 315730006988 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730006989 S-adenosylmethionine binding site [chemical binding]; other site 315730006990 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 315730006991 Domain of unknown function (DUF3974); Region: DUF3974; pfam13120 315730006992 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 315730006993 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 315730006994 active site 315730006995 P-loop; other site 315730006996 phosphorylation site [posttranslational modification] 315730006997 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 315730006998 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 315730006999 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 315730007000 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 315730007001 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 315730007002 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 315730007003 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730007004 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 315730007005 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 315730007006 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 315730007007 catalytic residue [active] 315730007008 Protein of unknown function (DUF3956); Region: DUF3956; pfam13104 315730007009 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 315730007010 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 315730007011 ATP binding site [chemical binding]; other site 315730007012 Mg++ binding site [ion binding]; other site 315730007013 motif III; other site 315730007014 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315730007015 nucleotide binding region [chemical binding]; other site 315730007016 ATP-binding site [chemical binding]; other site 315730007017 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730007018 Helix-turn-helix domains; Region: HTH; cl00088 315730007019 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730007020 putative substrate translocation pore; other site 315730007021 FtsX-like permease family; Region: FtsX; cl15850 315730007022 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 315730007023 FtsX-like permease family; Region: FtsX; cl15850 315730007024 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730007025 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 315730007026 Walker A/P-loop; other site 315730007027 ATP binding site [chemical binding]; other site 315730007028 Q-loop/lid; other site 315730007029 ABC transporter signature motif; other site 315730007030 Walker B; other site 315730007031 D-loop; other site 315730007032 H-loop/switch region; other site 315730007033 Methyltransferase domain; Region: Methyltransf_31; pfam13847 315730007034 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730007035 S-adenosylmethionine binding site [chemical binding]; other site 315730007036 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 315730007037 dimer interface [polypeptide binding]; other site 315730007038 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730007039 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 315730007040 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 315730007041 conserved cys residue [active] 315730007042 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315730007043 Helix-turn-helix domains; Region: HTH; cl00088 315730007044 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 315730007045 catalytic core [active] 315730007046 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 315730007047 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 315730007048 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 315730007049 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 315730007050 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 315730007051 metal binding site [ion binding]; metal-binding site 315730007052 dimer interface [polypeptide binding]; other site 315730007053 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 315730007054 trimer interface [polypeptide binding]; other site 315730007055 active site 315730007056 substrate binding site [chemical binding]; other site 315730007057 CoA binding site [chemical binding]; other site 315730007058 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730007059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730007060 active site 315730007061 phosphorylation site [posttranslational modification] 315730007062 intermolecular recognition site; other site 315730007063 dimerization interface [polypeptide binding]; other site 315730007064 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730007065 DNA binding site [nucleotide binding] 315730007066 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 315730007067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730007068 ATP binding site [chemical binding]; other site 315730007069 Mg2+ binding site [ion binding]; other site 315730007070 G-X-G motif; other site 315730007071 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730007072 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 315730007073 Walker A/P-loop; other site 315730007074 ATP binding site [chemical binding]; other site 315730007075 Q-loop/lid; other site 315730007076 ABC transporter signature motif; other site 315730007077 Walker B; other site 315730007078 D-loop; other site 315730007079 H-loop/switch region; other site 315730007080 hypothetical protein; Provisional; Region: PRK06760; cl11698 315730007081 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730007082 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 315730007083 Walker A/P-loop; other site 315730007084 ATP binding site [chemical binding]; other site 315730007085 Q-loop/lid; other site 315730007086 ABC transporter signature motif; other site 315730007087 Walker B; other site 315730007088 D-loop; other site 315730007089 H-loop/switch region; other site 315730007090 FtsX-like permease family; Region: FtsX; cl15850 315730007091 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730007092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730007093 active site 315730007094 phosphorylation site [posttranslational modification] 315730007095 intermolecular recognition site; other site 315730007096 dimerization interface [polypeptide binding]; other site 315730007097 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730007098 DNA binding site [nucleotide binding] 315730007099 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730007100 dimerization interface [polypeptide binding]; other site 315730007101 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730007102 dimer interface [polypeptide binding]; other site 315730007103 phosphorylation site [posttranslational modification] 315730007104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730007105 ATP binding site [chemical binding]; other site 315730007106 Mg2+ binding site [ion binding]; other site 315730007107 G-X-G motif; other site 315730007108 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 315730007109 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730007110 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 315730007111 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 315730007112 lysozyme catalytic site [active] 315730007113 OpgC protein; Region: OpgC_C; cl00792 315730007114 Acyltransferase family; Region: Acyl_transf_3; pfam01757 315730007115 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 315730007116 active site 315730007117 catalytic triad [active] 315730007118 oxyanion hole [active] 315730007119 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 315730007120 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315730007121 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730007122 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730007123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730007124 active site 315730007125 phosphorylation site [posttranslational modification] 315730007126 intermolecular recognition site; other site 315730007127 dimerization interface [polypeptide binding]; other site 315730007128 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730007129 DNA binding site [nucleotide binding] 315730007130 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730007131 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 315730007132 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730007133 ATP binding site [chemical binding]; other site 315730007134 Mg2+ binding site [ion binding]; other site 315730007135 G-X-G motif; other site 315730007136 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730007137 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 315730007138 Walker A/P-loop; other site 315730007139 ATP binding site [chemical binding]; other site 315730007140 Q-loop/lid; other site 315730007141 ABC transporter signature motif; other site 315730007142 Walker B; other site 315730007143 D-loop; other site 315730007144 H-loop/switch region; other site 315730007145 FtsX-like permease family; Region: FtsX; cl15850 315730007146 hypothetical protein; Provisional; Region: PRK06760; cl11698 315730007147 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 315730007148 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730007149 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730007150 DNA binding residues [nucleotide binding] 315730007151 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 315730007152 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315730007153 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730007154 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 315730007155 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315730007156 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315730007157 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730007158 beta-lactamase TEM; Provisional; Region: PRK15442 315730007159 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730007160 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 315730007161 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 315730007162 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 315730007163 Peptidase M60-like family; Region: M60-like; pfam13402 315730007164 Viral enhancin protein; Region: Enhancin; pfam03272 315730007165 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 315730007166 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315730007167 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 315730007168 active site residue [active] 315730007169 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 315730007170 active site residue [active] 315730007171 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 315730007172 Spore germination protein; Region: Spore_permease; cl15802 315730007173 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 315730007174 Fic family protein [Function unknown]; Region: COG3177 315730007175 Fic/DOC family; Region: Fic; cl00960 315730007176 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730007177 dimerization interface [polypeptide binding]; other site 315730007178 putative DNA binding site [nucleotide binding]; other site 315730007179 putative Zn2+ binding site [ion binding]; other site 315730007180 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730007181 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730007182 Helix-turn-helix domains; Region: HTH; cl00088 315730007183 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 315730007184 Chitin binding domain; Region: Chitin_bind_3; cl03871 315730007185 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 315730007186 Interdomain contacts; other site 315730007187 Cytokine receptor motif; other site 315730007188 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 315730007189 Interdomain contacts; other site 315730007190 Cytokine receptor motif; other site 315730007191 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 315730007192 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 315730007193 active site 315730007194 catalytic site [active] 315730007195 putative metal binding site [ion binding]; other site 315730007196 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 315730007197 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 315730007198 putative active site [active] 315730007199 putative metal binding site [ion binding]; other site 315730007200 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 315730007201 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730007202 Walker A/P-loop; other site 315730007203 ATP binding site [chemical binding]; other site 315730007204 Q-loop/lid; other site 315730007205 ABC transporter signature motif; other site 315730007206 Walker B; other site 315730007207 D-loop; other site 315730007208 H-loop/switch region; other site 315730007209 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 315730007210 ABC-2 type transporter; Region: ABC2_membrane; cl11417 315730007211 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730007212 Helix-turn-helix domains; Region: HTH; cl00088 315730007213 Protein of unknown function (DUF523); Region: DUF523; cl00733 315730007214 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 315730007215 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 315730007216 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 315730007217 FAD binding site [chemical binding]; other site 315730007218 homotetramer interface [polypeptide binding]; other site 315730007219 substrate binding pocket [chemical binding]; other site 315730007220 catalytic base [active] 315730007221 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 315730007222 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 315730007223 ATP-grasp domain; Region: ATP-grasp_4; cl03087 315730007224 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 315730007225 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 315730007226 carboxyltransferase (CT) interaction site; other site 315730007227 biotinylation site [posttranslational modification]; other site 315730007228 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 315730007229 active site 315730007230 catalytic residues [active] 315730007231 metal binding site [ion binding]; metal-binding site 315730007232 enoyl-CoA hydratase; Provisional; Region: PRK07657 315730007233 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 315730007234 substrate binding site [chemical binding]; other site 315730007235 oxyanion hole (OAH) forming residues; other site 315730007236 trimer interface [polypeptide binding]; other site 315730007237 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 315730007238 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 315730007239 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 315730007240 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 315730007241 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 315730007242 AMP-binding enzyme; Region: AMP-binding; cl15778 315730007243 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315730007244 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315730007245 Septum formation initiator; Region: DivIC; cl11433 315730007246 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315730007247 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730007248 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 315730007249 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730007250 active site 315730007251 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 315730007252 DinB superfamily; Region: DinB_2; pfam12867 315730007253 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 315730007254 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730007255 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730007256 dimer interface [polypeptide binding]; other site 315730007257 phosphorylation site [posttranslational modification] 315730007258 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730007259 ATP binding site [chemical binding]; other site 315730007260 Mg2+ binding site [ion binding]; other site 315730007261 G-X-G motif; other site 315730007262 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730007263 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730007264 active site 315730007265 phosphorylation site [posttranslational modification] 315730007266 intermolecular recognition site; other site 315730007267 dimerization interface [polypeptide binding]; other site 315730007268 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730007269 DNA binding site [nucleotide binding] 315730007270 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 315730007271 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 315730007272 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730007273 Coenzyme A binding pocket [chemical binding]; other site 315730007274 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730007275 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730007276 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 315730007277 putative hydrophobic ligand binding site [chemical binding]; other site 315730007278 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730007279 AAA domain; Region: AAA_21; pfam13304 315730007280 Walker A/P-loop; other site 315730007281 ATP binding site [chemical binding]; other site 315730007282 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730007283 ABC transporter signature motif; other site 315730007284 Walker B; other site 315730007285 D-loop; other site 315730007286 H-loop/switch region; other site 315730007287 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730007288 Walker A/P-loop; other site 315730007289 ATP binding site [chemical binding]; other site 315730007290 Q-loop/lid; other site 315730007291 ABC transporter signature motif; other site 315730007292 Walker B; other site 315730007293 D-loop; other site 315730007294 H-loop/switch region; other site 315730007295 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 315730007296 Helix-turn-helix domains; Region: HTH; cl00088 315730007297 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 315730007298 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730007299 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 315730007300 nudix motif; other site 315730007301 short chain dehydrogenase; Provisional; Region: PRK07041 315730007302 classical (c) SDRs; Region: SDR_c; cd05233 315730007303 NAD(P) binding site [chemical binding]; other site 315730007304 active site 315730007305 Helix-turn-helix domains; Region: HTH; cl00088 315730007306 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 315730007307 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730007308 S-adenosylmethionine binding site [chemical binding]; other site 315730007309 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315730007310 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730007311 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 315730007312 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 315730007313 active site 315730007314 metal binding site [ion binding]; metal-binding site 315730007315 Phosphotransferase enzyme family; Region: APH; pfam01636 315730007316 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 315730007317 active site 315730007318 substrate binding site [chemical binding]; other site 315730007319 ATP binding site [chemical binding]; other site 315730007320 Helix-turn-helix domains; Region: HTH; cl00088 315730007321 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 315730007322 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 315730007323 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730007324 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315730007325 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 315730007326 Cupin domain; Region: Cupin_2; cl09118 315730007327 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 315730007328 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315730007329 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 315730007330 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 315730007331 active site 315730007332 Zn binding site [ion binding]; other site 315730007333 EamA-like transporter family; Region: EamA; cl01037 315730007334 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 315730007335 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 315730007336 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730007337 DNA-binding site [nucleotide binding]; DNA binding site 315730007338 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315730007339 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730007340 homodimer interface [polypeptide binding]; other site 315730007341 catalytic residue [active] 315730007342 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 315730007343 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730007344 active site 315730007345 metal binding site [ion binding]; metal-binding site 315730007346 CAAX protease self-immunity; Region: Abi; cl00558 315730007347 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730007348 Protein of unknown function (DUF421); Region: DUF421; cl00990 315730007349 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730007350 Helix-turn-helix domains; Region: HTH; cl00088 315730007351 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 315730007352 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 315730007353 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730007354 DNA-binding site [nucleotide binding]; DNA binding site 315730007355 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315730007356 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730007357 homodimer interface [polypeptide binding]; other site 315730007358 catalytic residue [active] 315730007359 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 315730007360 EamA-like transporter family; Region: EamA; cl01037 315730007361 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 315730007362 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 315730007363 SecY translocase; Region: SecY; pfam00344 315730007364 DinB superfamily; Region: DinB_2; pfam12867 315730007365 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 315730007366 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 315730007367 active site 315730007368 metal binding site [ion binding]; metal-binding site 315730007369 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 315730007370 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 315730007371 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 315730007372 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 315730007373 active site 315730007374 Zn binding site [ion binding]; other site 315730007375 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 315730007376 carbohydrate binding site [chemical binding]; other site 315730007377 pullulanase, type I; Region: pulA_typeI; TIGR02104 315730007378 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 315730007379 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 315730007380 Ca binding site [ion binding]; other site 315730007381 active site 315730007382 catalytic site [active] 315730007383 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 315730007384 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 315730007385 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730007386 Coenzyme A binding pocket [chemical binding]; other site 315730007387 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 315730007388 FtsX-like permease family; Region: FtsX; cl15850 315730007389 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730007390 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 315730007391 Walker A/P-loop; other site 315730007392 ATP binding site [chemical binding]; other site 315730007393 Q-loop/lid; other site 315730007394 ABC transporter signature motif; other site 315730007395 Walker B; other site 315730007396 D-loop; other site 315730007397 H-loop/switch region; other site 315730007398 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730007399 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730007400 dimerization interface [polypeptide binding]; other site 315730007401 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730007402 dimer interface [polypeptide binding]; other site 315730007403 phosphorylation site [posttranslational modification] 315730007404 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730007405 ATP binding site [chemical binding]; other site 315730007406 Mg2+ binding site [ion binding]; other site 315730007407 G-X-G motif; other site 315730007408 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 315730007409 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730007410 active site 315730007411 phosphorylation site [posttranslational modification] 315730007412 intermolecular recognition site; other site 315730007413 dimerization interface [polypeptide binding]; other site 315730007414 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730007415 DNA binding site [nucleotide binding] 315730007416 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 315730007417 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730007418 motif II; other site 315730007419 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 315730007420 N-acetyltransferase; Region: Acetyltransf_2; cl00949 315730007421 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 315730007422 FAD dependent oxidoreductase; Region: DAO; pfam01266 315730007423 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730007424 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 315730007425 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 315730007426 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 315730007427 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730007428 Walker A/P-loop; other site 315730007429 ATP binding site [chemical binding]; other site 315730007430 Q-loop/lid; other site 315730007431 ABC transporter signature motif; other site 315730007432 Walker B; other site 315730007433 D-loop; other site 315730007434 H-loop/switch region; other site 315730007435 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 315730007436 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 315730007437 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 315730007438 Walker A/P-loop; other site 315730007439 ATP binding site [chemical binding]; other site 315730007440 Q-loop/lid; other site 315730007441 ABC transporter signature motif; other site 315730007442 Walker B; other site 315730007443 D-loop; other site 315730007444 H-loop/switch region; other site 315730007445 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 315730007446 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 315730007447 dimer interface [polypeptide binding]; other site 315730007448 PYR/PP interface [polypeptide binding]; other site 315730007449 TPP binding site [chemical binding]; other site 315730007450 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 315730007451 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 315730007452 TPP-binding site [chemical binding]; other site 315730007453 dimer interface [polypeptide binding]; other site 315730007454 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730007455 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730007456 Coenzyme A binding pocket [chemical binding]; other site 315730007457 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 315730007458 GIY-YIG motif/motif A; other site 315730007459 active site 315730007460 catalytic site [active] 315730007461 putative DNA binding site [nucleotide binding]; other site 315730007462 metal binding site [ion binding]; metal-binding site 315730007463 Bacitracin resistance protein BacA; Region: BacA; cl00858 315730007464 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 315730007465 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315730007466 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730007467 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 315730007468 DinB superfamily; Region: DinB_2; pfam12867 315730007469 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730007470 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 315730007471 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 315730007472 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 315730007473 active site 315730007474 nucleophile elbow; other site 315730007475 YxiJ-like protein; Region: YxiJ; pfam14176 315730007476 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 315730007477 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 315730007478 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315730007479 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 315730007480 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 315730007481 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 315730007482 homotrimer interaction site [polypeptide binding]; other site 315730007483 putative active site [active] 315730007484 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315730007485 DNA polymerase III subunit beta; Validated; Region: PRK06673 315730007486 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 315730007487 putative DNA binding surface [nucleotide binding]; other site 315730007488 dimer interface [polypeptide binding]; other site 315730007489 beta-clamp/clamp loader binding surface; other site 315730007490 beta-clamp/translesion DNA polymerase binding surface; other site 315730007491 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 315730007492 nudix motif; other site 315730007493 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730007494 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 315730007495 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730007496 putative substrate translocation pore; other site 315730007497 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730007498 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 315730007499 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_30; cd04689 315730007500 nudix motif; other site 315730007501 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 315730007502 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730007503 Coenzyme A binding pocket [chemical binding]; other site 315730007504 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 315730007505 active site 315730007506 EamA-like transporter family; Region: EamA; cl01037 315730007507 EamA-like transporter family; Region: EamA; cl01037 315730007508 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 315730007509 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730007510 DNA-binding site [nucleotide binding]; DNA binding site 315730007511 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315730007512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730007513 homodimer interface [polypeptide binding]; other site 315730007514 catalytic residue [active] 315730007515 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 315730007516 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 315730007517 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 315730007518 active site 315730007519 catalytic site [active] 315730007520 metal binding site [ion binding]; metal-binding site 315730007521 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730007522 Coenzyme A binding pocket [chemical binding]; other site 315730007523 Helix-turn-helix domains; Region: HTH; cl00088 315730007524 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 315730007525 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 315730007526 NADP binding site [chemical binding]; other site 315730007527 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 315730007528 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 315730007529 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730007530 Walker A/P-loop; other site 315730007531 ATP binding site [chemical binding]; other site 315730007532 Q-loop/lid; other site 315730007533 ABC transporter signature motif; other site 315730007534 Walker B; other site 315730007535 D-loop; other site 315730007536 H-loop/switch region; other site 315730007537 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 315730007538 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 315730007539 VanZ like family; Region: VanZ; cl01971 315730007540 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730007541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730007542 putative substrate translocation pore; other site 315730007543 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730007544 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 315730007545 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315730007546 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730007547 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 315730007548 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 315730007549 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 315730007550 active site 315730007551 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 315730007552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730007553 NAD(P) binding site [chemical binding]; other site 315730007554 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730007555 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 315730007556 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730007557 dimer interface [polypeptide binding]; other site 315730007558 phosphorylation site [posttranslational modification] 315730007559 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730007560 ATP binding site [chemical binding]; other site 315730007561 Mg2+ binding site [ion binding]; other site 315730007562 G-X-G motif; other site 315730007563 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730007564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730007565 active site 315730007566 phosphorylation site [posttranslational modification] 315730007567 intermolecular recognition site; other site 315730007568 dimerization interface [polypeptide binding]; other site 315730007569 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730007570 DNA binding site [nucleotide binding] 315730007571 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 315730007572 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 315730007573 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730007574 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730007575 dimer interface [polypeptide binding]; other site 315730007576 phosphorylation site [posttranslational modification] 315730007577 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730007578 ATP binding site [chemical binding]; other site 315730007579 Mg2+ binding site [ion binding]; other site 315730007580 G-X-G motif; other site 315730007581 Cobalt transport protein; Region: CbiQ; cl00463 315730007582 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 315730007583 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 315730007584 Walker A/P-loop; other site 315730007585 ATP binding site [chemical binding]; other site 315730007586 Q-loop/lid; other site 315730007587 ABC transporter signature motif; other site 315730007588 Walker B; other site 315730007589 D-loop; other site 315730007590 H-loop/switch region; other site 315730007591 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 315730007592 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 315730007593 Walker A/P-loop; other site 315730007594 ATP binding site [chemical binding]; other site 315730007595 Q-loop/lid; other site 315730007596 ABC transporter signature motif; other site 315730007597 Walker B; other site 315730007598 D-loop; other site 315730007599 H-loop/switch region; other site 315730007600 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 315730007601 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 315730007602 aspartate racemase; Region: asp_race; TIGR00035 315730007603 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 315730007604 homodimer interface [polypeptide binding]; other site 315730007605 glycosyltransferase, MGT family; Region: MGT; TIGR01426 315730007606 active site 315730007607 TDP-binding site; other site 315730007608 acceptor substrate-binding pocket; other site 315730007609 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 315730007610 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 315730007611 Catalytic site [active] 315730007612 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 315730007613 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315730007614 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315730007615 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730007616 PAS domain S-box; Region: sensory_box; TIGR00229 315730007617 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315730007618 putative active site [active] 315730007619 heme pocket [chemical binding]; other site 315730007620 sensory histidine kinase AtoS; Provisional; Region: PRK11360 315730007621 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730007622 dimer interface [polypeptide binding]; other site 315730007623 phosphorylation site [posttranslational modification] 315730007624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730007625 ATP binding site [chemical binding]; other site 315730007626 Mg2+ binding site [ion binding]; other site 315730007627 G-X-G motif; other site 315730007628 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730007629 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 315730007630 active site 315730007631 motif I; other site 315730007632 motif II; other site 315730007633 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 315730007634 Cysteine dioxygenase type I; Region: CDO_I; cl15835 315730007635 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 315730007636 Helix-turn-helix domains; Region: HTH; cl00088 315730007637 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 315730007638 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 315730007639 trimer interface [polypeptide binding]; other site 315730007640 active site 315730007641 substrate binding site [chemical binding]; other site 315730007642 CoA binding site [chemical binding]; other site 315730007643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730007644 H+ Antiporter protein; Region: 2A0121; TIGR00900 315730007645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730007646 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 315730007647 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 315730007648 Protein of unknown function; Region: DUF3658; pfam12395 315730007649 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 315730007650 Protein of unknown function (DUF3959); Region: DUF3959; pfam13105 315730007651 Protein of unknown function (DUF3962); Region: DUF3962; pfam13111 315730007652 Domain of unknown function (DUF3893); Region: DUF3893; pfam13032 315730007653 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 315730007654 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 315730007655 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 315730007656 ATP-grasp domain; Region: ATP-grasp_4; cl03087 315730007657 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 315730007658 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730007659 DNA-binding site [nucleotide binding]; DNA binding site 315730007660 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315730007661 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730007662 homodimer interface [polypeptide binding]; other site 315730007663 catalytic residue [active] 315730007664 homoserine dehydrogenase; Validated; Region: PRK06813 315730007665 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730007666 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 315730007667 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 315730007668 Protein of unknown function (DUF3914); Region: DUF3914; pfam13053 315730007669 hypothetical protein; Provisional; Region: PRK06760; cl11698 315730007670 FtsX-like permease family; Region: FtsX; cl15850 315730007671 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730007672 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 315730007673 Walker A/P-loop; other site 315730007674 ATP binding site [chemical binding]; other site 315730007675 Q-loop/lid; other site 315730007676 ABC transporter signature motif; other site 315730007677 Walker B; other site 315730007678 D-loop; other site 315730007679 H-loop/switch region; other site 315730007680 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 315730007681 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730007682 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730007683 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 315730007684 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 315730007685 ABC transporter; Region: ABC_tran_2; pfam12848 315730007686 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 315730007687 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 315730007688 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 315730007689 active site 315730007690 catalytic tetrad [active] 315730007691 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 315730007692 Helix-turn-helix domains; Region: HTH; cl00088 315730007693 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 315730007694 dimerization interface [polypeptide binding]; other site 315730007695 substrate binding pocket [chemical binding]; other site 315730007696 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730007697 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 315730007698 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730007699 ATP binding site [chemical binding]; other site 315730007700 Mg2+ binding site [ion binding]; other site 315730007701 G-X-G motif; other site 315730007702 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730007703 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730007704 active site 315730007705 phosphorylation site [posttranslational modification] 315730007706 intermolecular recognition site; other site 315730007707 dimerization interface [polypeptide binding]; other site 315730007708 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730007709 DNA binding site [nucleotide binding] 315730007710 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 315730007711 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 315730007712 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 315730007713 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 315730007714 putative NAD(P) binding site [chemical binding]; other site 315730007715 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 315730007716 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315730007717 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 315730007718 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730007719 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 315730007720 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 315730007721 germination protein YpeB; Region: spore_YpeB; TIGR02889 315730007722 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 315730007723 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 315730007724 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 315730007725 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 315730007726 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730007727 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 315730007728 Putative cyclase; Region: Cyclase; cl00814 315730007729 kynureninase; Region: kynureninase; TIGR01814 315730007730 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 315730007731 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 315730007732 catalytic residue [active] 315730007733 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730007734 Helix-turn-helix domains; Region: HTH; cl00088 315730007735 Protein of unknown function (DUF3977); Region: DUF3977; pfam13122 315730007736 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 315730007737 GAF domain; Region: GAF; cl15785 315730007738 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730007739 Walker A motif; other site 315730007740 ATP binding site [chemical binding]; other site 315730007741 Walker B motif; other site 315730007742 arginine finger; other site 315730007743 Helix-turn-helix domains; Region: HTH; cl00088 315730007744 NIPSNAP; Region: NIPSNAP; pfam07978 315730007745 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 315730007746 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730007747 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 315730007748 Helix-turn-helix domains; Region: HTH; cl00088 315730007749 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 315730007750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730007751 S-adenosylmethionine binding site [chemical binding]; other site 315730007752 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 315730007753 Rrf2 family protein; Region: rrf2_super; TIGR00738 315730007754 Helix-turn-helix domains; Region: HTH; cl00088 315730007755 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 315730007756 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730007757 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315730007758 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 315730007759 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 315730007760 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 315730007761 E3 interaction surface; other site 315730007762 lipoyl attachment site [posttranslational modification]; other site 315730007763 e3 binding domain; Region: E3_binding; pfam02817 315730007764 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 315730007765 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 315730007766 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 315730007767 alpha subunit interface [polypeptide binding]; other site 315730007768 TPP binding site [chemical binding]; other site 315730007769 heterodimer interface [polypeptide binding]; other site 315730007770 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 315730007771 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 315730007772 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 315730007773 tetramer interface [polypeptide binding]; other site 315730007774 TPP-binding site [chemical binding]; other site 315730007775 heterodimer interface [polypeptide binding]; other site 315730007776 phosphorylation loop region [posttranslational modification] 315730007777 DinB superfamily; Region: DinB_2; pfam12867 315730007778 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 315730007779 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730007780 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730007781 putative substrate translocation pore; other site 315730007782 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 315730007783 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315730007784 short chain dehydrogenase; Provisional; Region: PRK06914 315730007785 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 315730007786 NADP binding site [chemical binding]; other site 315730007787 active site 315730007788 steroid binding site; other site 315730007789 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 315730007790 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 315730007791 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 315730007792 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 315730007793 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 315730007794 nucleotide binding site/active site [active] 315730007795 HIT family signature motif; other site 315730007796 catalytic residue [active] 315730007797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730007798 dimer interface [polypeptide binding]; other site 315730007799 conserved gate region; other site 315730007800 putative PBP binding loops; other site 315730007801 ABC-ATPase subunit interface; other site 315730007802 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 315730007803 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 315730007804 Walker A/P-loop; other site 315730007805 ATP binding site [chemical binding]; other site 315730007806 Q-loop/lid; other site 315730007807 ABC transporter signature motif; other site 315730007808 Walker B; other site 315730007809 D-loop; other site 315730007810 H-loop/switch region; other site 315730007811 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 315730007812 NMT1-like family; Region: NMT1_2; cl15260 315730007813 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 315730007814 Clp protease; Region: CLP_protease; pfam00574 315730007815 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 315730007816 oligomer interface [polypeptide binding]; other site 315730007817 active site residues [active] 315730007818 RNA polymerase factor sigma-70; Validated; Region: PRK06704 315730007819 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730007820 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 315730007821 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 315730007822 catalytic loop [active] 315730007823 iron binding site [ion binding]; other site 315730007824 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 315730007825 tetramer (dimer of dimers) interface [polypeptide binding]; other site 315730007826 active site 315730007827 dimer interface [polypeptide binding]; other site 315730007828 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730007829 Coenzyme A binding pocket [chemical binding]; other site 315730007830 Chitin binding domain; Region: Chitin_bind_3; cl03871 315730007831 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 315730007832 Interdomain contacts; other site 315730007833 Cytokine receptor motif; other site 315730007834 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 315730007835 Interdomain contacts; other site 315730007836 Cytokine receptor motif; other site 315730007837 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 315730007838 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 315730007839 glycosyltransferase, MGT family; Region: MGT; TIGR01426 315730007840 active site 315730007841 TDP-binding site; other site 315730007842 acceptor substrate-binding pocket; other site 315730007843 homodimer interface [polypeptide binding]; other site 315730007844 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 315730007845 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730007846 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 315730007847 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315730007848 active site 315730007849 ATP binding site [chemical binding]; other site 315730007850 substrate binding site [chemical binding]; other site 315730007851 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 315730007852 Protein of unknown function (DUF419); Region: DUF419; cl15265 315730007853 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730007854 Coenzyme A binding pocket [chemical binding]; other site 315730007855 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730007856 Coenzyme A binding pocket [chemical binding]; other site 315730007857 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730007858 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 315730007859 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730007860 Coenzyme A binding pocket [chemical binding]; other site 315730007861 Helix-turn-helix domains; Region: HTH; cl00088 315730007862 Protein of unknown function (DUF952); Region: DUF952; cl01393 315730007863 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 315730007864 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730007865 Family description; Region: UvrD_C_2; cl15862 315730007866 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730007867 S-adenosylmethionine binding site [chemical binding]; other site 315730007868 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 315730007869 putative active site pocket [active] 315730007870 dimerization interface [polypeptide binding]; other site 315730007871 putative catalytic residue [active] 315730007872 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 315730007873 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315730007874 ATP binding site [chemical binding]; other site 315730007875 putative Mg++ binding site [ion binding]; other site 315730007876 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315730007877 nucleotide binding region [chemical binding]; other site 315730007878 ATP-binding site [chemical binding]; other site 315730007879 RQC domain; Region: RQC; cl09632 315730007880 HRDC domain; Region: HRDC; cl02578 315730007881 Protein of unknown function (DUF4017); Region: DUF4017; pfam13209 315730007882 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 315730007883 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 315730007884 active site 315730007885 Zn binding site [ion binding]; other site 315730007886 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 315730007887 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 315730007888 DHHA2 domain; Region: DHHA2; pfam02833 315730007889 Chitin binding domain; Region: Chitin_bind_3; cl03871 315730007890 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 315730007891 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730007892 Coenzyme A binding pocket [chemical binding]; other site 315730007893 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 315730007894 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 315730007895 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 315730007896 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730007897 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 315730007898 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 315730007899 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 315730007900 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 315730007901 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 315730007902 NAD(P) binding site [chemical binding]; other site 315730007903 catalytic residues [active] 315730007904 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 315730007905 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 315730007906 inhibitor site; inhibition site 315730007907 active site 315730007908 dimer interface [polypeptide binding]; other site 315730007909 catalytic residue [active] 315730007910 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 315730007911 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 315730007912 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 315730007913 Proline racemase; Region: Pro_racemase; pfam05544 315730007914 FAD dependent oxidoreductase; Region: DAO; pfam01266 315730007915 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 315730007916 PAS domain; Region: PAS_10; pfam13596 315730007917 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 315730007918 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730007919 Walker A motif; other site 315730007920 ATP binding site [chemical binding]; other site 315730007921 Walker B motif; other site 315730007922 arginine finger; other site 315730007923 Helix-turn-helix domains; Region: HTH; cl00088 315730007924 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 315730007925 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 315730007926 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 315730007927 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730007928 Glucose inhibited division protein A; Region: GIDA; pfam01134 315730007929 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 315730007930 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 315730007931 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 315730007932 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 315730007933 DinB superfamily; Region: DinB_2; pfam12867 315730007934 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 315730007935 DltD N-terminal region; Region: DltD_N; pfam04915 315730007936 DltD central region; Region: DltD_M; pfam04918 315730007937 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 315730007938 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 315730007939 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 315730007940 peptide binding site [polypeptide binding]; other site 315730007941 NlpC/P60 family; Region: NLPC_P60; cl11438 315730007942 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 315730007943 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 315730007944 active site 315730007945 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 315730007946 Septum formation initiator; Region: DivIC; cl11433 315730007947 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 315730007948 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 315730007949 active site 315730007950 catalytic tetrad [active] 315730007951 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 315730007952 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 315730007953 conserved cys residue [active] 315730007954 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 315730007955 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 315730007956 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 315730007957 lysozyme catalytic site [active] 315730007958 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730007959 S-adenosylmethionine binding site [chemical binding]; other site 315730007960 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 315730007961 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315730007962 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 315730007963 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 315730007964 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730007965 dimerization interface [polypeptide binding]; other site 315730007966 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730007967 dimer interface [polypeptide binding]; other site 315730007968 phosphorylation site [posttranslational modification] 315730007969 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730007970 ATP binding site [chemical binding]; other site 315730007971 Mg2+ binding site [ion binding]; other site 315730007972 G-X-G motif; other site 315730007973 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730007974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730007975 active site 315730007976 phosphorylation site [posttranslational modification] 315730007977 intermolecular recognition site; other site 315730007978 dimerization interface [polypeptide binding]; other site 315730007979 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730007980 DNA binding site [nucleotide binding] 315730007981 DinB superfamily; Region: DinB_2; pfam12867 315730007982 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 315730007983 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 315730007984 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730007985 motif II; other site 315730007986 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 315730007987 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 315730007988 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 315730007989 Zn binding site [ion binding]; other site 315730007990 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 315730007991 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730007992 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 315730007993 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730007994 non-specific DNA binding site [nucleotide binding]; other site 315730007995 salt bridge; other site 315730007996 sequence-specific DNA binding site [nucleotide binding]; other site 315730007997 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315730007998 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 315730007999 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730008000 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730008001 Isochorismatase family; Region: Isochorismatase; pfam00857 315730008002 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 315730008003 catalytic triad [active] 315730008004 dimer interface [polypeptide binding]; other site 315730008005 conserved cis-peptide bond; other site 315730008006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730008007 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730008008 putative substrate translocation pore; other site 315730008009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730008010 putative substrate translocation pore; other site 315730008011 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 315730008012 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 315730008013 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 315730008014 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 315730008015 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 315730008016 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730008017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730008018 putative substrate translocation pore; other site 315730008019 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 315730008020 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 315730008021 active site 315730008022 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 315730008023 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730008024 S-adenosylmethionine binding site [chemical binding]; other site 315730008025 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730008026 putative substrate translocation pore; other site 315730008027 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730008028 aspartate aminotransferase; Provisional; Region: PRK07681 315730008029 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315730008030 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730008031 homodimer interface [polypeptide binding]; other site 315730008032 catalytic residue [active] 315730008033 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 315730008034 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 315730008035 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 315730008036 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 315730008037 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 315730008038 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 315730008039 Protein of unknown function (DUF4052); Region: DUF4052; pfam13261 315730008040 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315730008041 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 315730008042 Walker A/P-loop; other site 315730008043 ATP binding site [chemical binding]; other site 315730008044 Q-loop/lid; other site 315730008045 ABC transporter signature motif; other site 315730008046 Walker B; other site 315730008047 D-loop; other site 315730008048 H-loop/switch region; other site 315730008049 Predicted transcriptional regulators [Transcription]; Region: COG1725 315730008050 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730008051 DNA-binding site [nucleotide binding]; DNA binding site 315730008052 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 315730008053 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 315730008054 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 315730008055 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 315730008056 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 315730008057 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 315730008058 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 315730008059 Domain of unknown function DUF20; Region: UPF0118; pfam01594 315730008060 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 315730008061 HNH endonuclease; Region: HNH_5; pfam14279 315730008062 Protein of unknown function (DUF402); Region: DUF402; cl00979 315730008063 Tetratrico peptide repeat; Region: TPR_5; pfam12688 315730008064 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 315730008065 binding surface 315730008066 TPR motif; other site 315730008067 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 315730008068 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 315730008069 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730008070 EamA-like transporter family; Region: EamA; cl01037 315730008071 DinB superfamily; Region: DinB_2; pfam12867 315730008072 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 315730008073 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 315730008074 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730008075 Coenzyme A binding pocket [chemical binding]; other site 315730008076 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730008077 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730008078 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 315730008079 active site 315730008080 NTP binding site [chemical binding]; other site 315730008081 metal binding triad [ion binding]; metal-binding site 315730008082 antibiotic binding site [chemical binding]; other site 315730008083 A new structural DNA glycosylase; Region: AlkD_like; cd06561 315730008084 active site 315730008085 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 315730008086 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 315730008087 NodB motif; other site 315730008088 active site 315730008089 catalytic site [active] 315730008090 Zn binding site [ion binding]; other site 315730008091 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 315730008092 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 315730008093 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730008094 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730008095 putative substrate translocation pore; other site 315730008096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730008097 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 315730008098 Sulfatase; Region: Sulfatase; cl10460 315730008099 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 315730008100 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730008101 Helix-turn-helix domains; Region: HTH; cl00088 315730008102 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 315730008103 nudix motif; other site 315730008104 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730008105 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 315730008106 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 315730008107 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 315730008108 hinge; other site 315730008109 active site 315730008110 prephenate dehydrogenase; Validated; Region: PRK06545 315730008111 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730008112 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 315730008113 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 315730008114 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315730008115 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730008116 homodimer interface [polypeptide binding]; other site 315730008117 catalytic residue [active] 315730008118 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 315730008119 Tetramer interface [polypeptide binding]; other site 315730008120 active site 315730008121 FMN-binding site [chemical binding]; other site 315730008122 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 315730008123 Chorismate mutase type II; Region: CM_2; cl00693 315730008124 NeuB family; Region: NeuB; cl00496 315730008125 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 315730008126 Domain of unknown function (DUF4020); Region: DUF4020; pfam13212 315730008127 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 315730008128 Isochorismatase family; Region: Isochorismatase; pfam00857 315730008129 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 315730008130 catalytic triad [active] 315730008131 conserved cis-peptide bond; other site 315730008132 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730008133 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730008134 seryl-tRNA synthetase; Provisional; Region: PRK05431 315730008135 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 315730008136 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 315730008137 dimer interface [polypeptide binding]; other site 315730008138 active site 315730008139 motif 1; other site 315730008140 motif 2; other site 315730008141 motif 3; other site 315730008142 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730008143 Bacterial SH3 domain; Region: SH3_3; cl02551 315730008144 Bacterial SH3 domain; Region: SH3_3; cl02551 315730008145 3D domain; Region: 3D; cl01439 315730008146 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 315730008147 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730008148 putative metal binding site [ion binding]; other site 315730008149 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730008150 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730008151 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 315730008152 RNA polymerase sigma factor; Provisional; Region: PRK12543 315730008153 DinB superfamily; Region: DinB_2; pfam12867 315730008154 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 315730008155 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837 315730008156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730008157 Predicted dehydrogenase [General function prediction only]; Region: COG0579 315730008158 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 315730008159 TM-ABC transporter signature motif; other site 315730008160 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 315730008161 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 315730008162 Walker A/P-loop; other site 315730008163 ATP binding site [chemical binding]; other site 315730008164 Q-loop/lid; other site 315730008165 ABC transporter signature motif; other site 315730008166 Walker B; other site 315730008167 D-loop; other site 315730008168 H-loop/switch region; other site 315730008169 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 315730008170 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 315730008171 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 315730008172 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 315730008173 Autoinducer-2 kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 315730008174 putative N- and C-terminal domain interface [polypeptide binding]; other site 315730008175 putative active site [active] 315730008176 putative MgATP binding site [chemical binding]; other site 315730008177 catalytic site [active] 315730008178 metal binding site [ion binding]; metal-binding site 315730008179 putative carbohydrate binding site [chemical binding]; other site 315730008180 Cupin domain; Region: Cupin_2; cl09118 315730008181 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 315730008182 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 315730008183 putative active site; other site 315730008184 catalytic residue [active] 315730008185 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730008186 S-adenosylmethionine binding site [chemical binding]; other site 315730008187 Chorismate mutase type II; Region: CM_2; cl00693 315730008188 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 315730008189 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730008190 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 315730008191 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 315730008192 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730008193 dimerization interface [polypeptide binding]; other site 315730008194 putative DNA binding site [nucleotide binding]; other site 315730008195 putative Zn2+ binding site [ion binding]; other site 315730008196 DinB superfamily; Region: DinB_2; pfam12867 315730008197 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 315730008198 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 315730008199 Fibronectin type III-like domain; Region: Fn3-like; cl15273 315730008200 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 315730008201 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 315730008202 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315730008203 nucleoside transporter; Region: nupC; TIGR00804 315730008204 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 315730008205 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 315730008206 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 315730008207 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 315730008208 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 315730008209 putative catalytic cysteine [active] 315730008210 gamma-glutamyl kinase; Provisional; Region: PRK05429 315730008211 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 315730008212 nucleotide binding site [chemical binding]; other site 315730008213 homotetrameric interface [polypeptide binding]; other site 315730008214 putative phosphate binding site [ion binding]; other site 315730008215 putative allosteric binding site; other site 315730008216 PUA domain; Region: PUA; cl00607 315730008217 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730008218 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 315730008219 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 315730008220 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 315730008221 putative di-iron ligands [ion binding]; other site 315730008222 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 315730008223 active site 315730008224 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 315730008225 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 315730008226 Walker A/P-loop; other site 315730008227 ATP binding site [chemical binding]; other site 315730008228 Q-loop/lid; other site 315730008229 Walker B; other site 315730008230 D-loop; other site 315730008231 H-loop/switch region; other site 315730008232 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 315730008233 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730008234 motif II; other site 315730008235 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 315730008236 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 315730008237 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 315730008238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730008239 dimer interface [polypeptide binding]; other site 315730008240 conserved gate region; other site 315730008241 putative PBP binding loops; other site 315730008242 ABC-ATPase subunit interface; other site 315730008243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730008244 dimer interface [polypeptide binding]; other site 315730008245 conserved gate region; other site 315730008246 putative PBP binding loops; other site 315730008247 ABC-ATPase subunit interface; other site 315730008248 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 315730008249 Helix-turn-helix domains; Region: HTH; cl00088 315730008250 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 315730008251 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 315730008252 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 315730008253 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730008254 active site 315730008255 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730008256 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730008257 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730008258 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 315730008259 active site 315730008260 metal binding site [ion binding]; metal-binding site 315730008261 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 315730008262 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 315730008263 Helix-turn-helix domains; Region: HTH; cl00088 315730008264 MoxR-like ATPases [General function prediction only]; Region: COG0714 315730008265 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730008266 Walker A motif; other site 315730008267 ATP binding site [chemical binding]; other site 315730008268 Walker B motif; other site 315730008269 arginine finger; other site 315730008270 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 315730008271 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 315730008272 Domain of unknown function (DUF4018); Region: DUF4018; pfam13210 315730008273 proline/glycine betaine transporter; Provisional; Region: PRK10642 315730008274 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730008275 putative substrate translocation pore; other site 315730008276 acetylornithine aminotransferase; Provisional; Region: PRK02627 315730008277 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315730008278 inhibitor-cofactor binding pocket; inhibition site 315730008279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730008280 catalytic residue [active] 315730008281 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 315730008282 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 315730008283 heme binding pocket [chemical binding]; other site 315730008284 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 315730008285 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 315730008286 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 315730008287 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 315730008288 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 315730008289 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 315730008290 active site 315730008291 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 315730008292 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730008293 Protein of unknown function (DUF3902); Region: DUF3902; pfam13042 315730008294 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 315730008295 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 315730008296 dimer interface [polypeptide binding]; other site 315730008297 FMN binding site [chemical binding]; other site 315730008298 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315730008299 Helix-turn-helix domains; Region: HTH; cl00088 315730008300 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 315730008301 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 315730008302 G1 box; other site 315730008303 putative GEF interaction site [polypeptide binding]; other site 315730008304 GTP/Mg2+ binding site [chemical binding]; other site 315730008305 Switch I region; other site 315730008306 G2 box; other site 315730008307 G3 box; other site 315730008308 Switch II region; other site 315730008309 G4 box; other site 315730008310 G5 box; other site 315730008311 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 315730008312 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 315730008313 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 315730008314 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 315730008315 nudix motif; other site 315730008316 WGR domain; Region: WGR; cl01581 315730008317 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 315730008318 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 315730008319 NADH(P)-binding; Region: NAD_binding_10; pfam13460 315730008320 putative NAD(P) binding site [chemical binding]; other site 315730008321 active site 315730008322 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730008323 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 315730008324 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315730008325 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 315730008326 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 315730008327 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730008328 Coenzyme A binding pocket [chemical binding]; other site 315730008329 Domain of unknown function (DUF3980); Region: DUF3980; pfam13140 315730008330 EamA-like transporter family; Region: EamA; cl01037 315730008331 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 315730008332 EamA-like transporter family; Region: EamA; cl01037 315730008333 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 315730008334 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730008335 DNA-binding site [nucleotide binding]; DNA binding site 315730008336 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315730008337 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730008338 homodimer interface [polypeptide binding]; other site 315730008339 catalytic residue [active] 315730008340 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 315730008341 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 315730008342 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730008343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730008344 ATP binding site [chemical binding]; other site 315730008345 Mg2+ binding site [ion binding]; other site 315730008346 G-X-G motif; other site 315730008347 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730008348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730008349 active site 315730008350 phosphorylation site [posttranslational modification] 315730008351 intermolecular recognition site; other site 315730008352 dimerization interface [polypeptide binding]; other site 315730008353 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730008354 DNA binding site [nucleotide binding] 315730008355 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730008356 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 315730008357 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 315730008358 uridine kinase; Validated; Region: PRK06696 315730008359 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730008360 active site 315730008361 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 315730008362 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 315730008363 active site 315730008364 metal binding site [ion binding]; metal-binding site 315730008365 Phosphotransferase enzyme family; Region: APH; pfam01636 315730008366 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315730008367 active site 315730008368 ATP binding site [chemical binding]; other site 315730008369 substrate binding site [chemical binding]; other site 315730008370 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 315730008371 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 315730008372 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 315730008373 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730008374 lysine transporter; Provisional; Region: PRK10836 315730008375 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 315730008376 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 315730008377 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730008378 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 315730008379 putative active site [active] 315730008380 nucleotide binding site [chemical binding]; other site 315730008381 nudix motif; other site 315730008382 putative metal binding site [ion binding]; other site 315730008383 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730008384 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 315730008385 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 315730008386 Catalytic site [active] 315730008387 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 315730008388 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315730008389 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315730008390 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730008391 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 315730008392 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 315730008393 Probable transposase; Region: OrfB_IS605; pfam01385 315730008394 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 315730008395 NAD-dependent deacetylase; Provisional; Region: PRK00481 315730008396 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 315730008397 NAD+ binding site [chemical binding]; other site 315730008398 substrate binding site [chemical binding]; other site 315730008399 Zn binding site [ion binding]; other site 315730008400 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 315730008401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730008402 putative substrate translocation pore; other site 315730008403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 315730008404 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 315730008405 putative substrate binding pocket [chemical binding]; other site 315730008406 AC domain interface; other site 315730008407 catalytic triad [active] 315730008408 AB domain interface; other site 315730008409 interchain disulfide; other site 315730008410 Protein of unknown function (DUF979); Region: DUF979; cl01572 315730008411 Protein of unknown function (DUF969); Region: DUF969; cl01573 315730008412 LamB/YcsF family; Region: LamB_YcsF; cl00664 315730008413 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 315730008414 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 315730008415 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 315730008416 Transcriptional regulator [Transcription]; Region: IclR; COG1414 315730008417 Helix-turn-helix domains; Region: HTH; cl00088 315730008418 Bacterial transcriptional regulator; Region: IclR; pfam01614 315730008419 A new structural DNA glycosylase; Region: AlkD_like; cl11434 315730008420 active site 315730008421 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 315730008422 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 315730008423 Catalytic site [active] 315730008424 CutC family; Region: CutC; cl01218 315730008425 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 315730008426 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 315730008427 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 315730008428 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 315730008429 putative active site [active] 315730008430 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315730008431 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730008432 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730008433 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 315730008434 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 315730008435 putative hydrophobic ligand binding site [chemical binding]; other site 315730008436 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730008437 dimerization interface [polypeptide binding]; other site 315730008438 putative DNA binding site [nucleotide binding]; other site 315730008439 putative Zn2+ binding site [ion binding]; other site 315730008440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 315730008441 Nucleoside recognition; Region: Gate; cl00486 315730008442 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 315730008443 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such...; Region: APH_ChoK_like_1; cd05155 315730008444 putative active site [active] 315730008445 putative substrate binding site [chemical binding]; other site 315730008446 ATP binding site [chemical binding]; other site 315730008447 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 315730008448 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 315730008449 dinuclear metal binding motif [ion binding]; other site 315730008450 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 315730008451 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 315730008452 ABC-2 type transporter; Region: ABC2_membrane; cl11417 315730008453 Helix-turn-helix domains; Region: HTH; cl00088 315730008454 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 315730008455 phosphoenolpyruvate synthase; Validated; Region: PRK06241 315730008456 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 315730008457 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 315730008458 DNA polymerase IV; Reviewed; Region: PRK03103 315730008459 YolD-like protein; Region: YolD; pfam08863 315730008460 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 315730008461 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 315730008462 Probable transposase; Region: OrfB_IS605; pfam01385 315730008463 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 315730008464 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 315730008465 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 315730008466 putative active site [active] 315730008467 putative metal binding site [ion binding]; other site 315730008468 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 315730008469 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 315730008470 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 315730008471 plasmid segregation protein ParM; Provisional; Region: PRK13917 315730008472 Heat induced stress protein YflT; Region: YflT; pfam11181 315730008473 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 315730008474 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315730008475 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 315730008476 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 315730008477 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 315730008478 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 315730008479 NodB motif; other site 315730008480 active site 315730008481 catalytic site [active] 315730008482 Zn binding site [ion binding]; other site 315730008483 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 315730008484 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 315730008485 active site 315730008486 metal binding site [ion binding]; metal-binding site 315730008487 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730008488 dimerization interface [polypeptide binding]; other site 315730008489 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730008490 dimer interface [polypeptide binding]; other site 315730008491 phosphorylation site [posttranslational modification] 315730008492 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730008493 ATP binding site [chemical binding]; other site 315730008494 Mg2+ binding site [ion binding]; other site 315730008495 G-X-G motif; other site 315730008496 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730008497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730008498 active site 315730008499 phosphorylation site [posttranslational modification] 315730008500 intermolecular recognition site; other site 315730008501 dimerization interface [polypeptide binding]; other site 315730008502 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730008503 DNA binding site [nucleotide binding] 315730008504 UbiA prenyltransferase family; Region: UbiA; cl00337 315730008505 DJ-1 family protein; Region: not_thiJ; TIGR01383 315730008506 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 315730008507 conserved cys residue [active] 315730008508 Phosphotransferase enzyme family; Region: APH; pfam01636 315730008509 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315730008510 Low molecular weight phosphatase family; Region: LMWPc; cd00115 315730008511 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 315730008512 active site 315730008513 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 315730008514 Membrane transport protein; Region: Mem_trans; cl09117 315730008515 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730008516 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 315730008517 putative metal binding site [ion binding]; other site 315730008518 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730008519 dimerization interface [polypeptide binding]; other site 315730008520 putative DNA binding site [nucleotide binding]; other site 315730008521 putative Zn2+ binding site [ion binding]; other site 315730008522 DinB superfamily; Region: DinB_2; pfam12867 315730008523 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 315730008524 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 315730008525 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 315730008526 putative NAD(P) binding site [chemical binding]; other site 315730008527 active site 315730008528 putative substrate binding site [chemical binding]; other site 315730008529 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730008530 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315730008531 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730008532 Helix-turn-helix domains; Region: HTH; cl00088 315730008533 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 315730008534 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 315730008535 NADP binding site [chemical binding]; other site 315730008536 homodimer interface [polypeptide binding]; other site 315730008537 active site 315730008538 substrate binding site [chemical binding]; other site 315730008539 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730008540 putative DNA binding site [nucleotide binding]; other site 315730008541 putative Zn2+ binding site [ion binding]; other site 315730008542 Helix-turn-helix domains; Region: HTH; cl00088 315730008543 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 315730008544 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 315730008545 metal binding site [ion binding]; metal-binding site 315730008546 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730008547 Family description; Region: UvrD_C_2; cl15862 315730008548 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 315730008549 putative active site [active] 315730008550 catalytic site [active] 315730008551 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730008552 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 315730008553 active site 315730008554 metal binding site [ion binding]; metal-binding site 315730008555 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 315730008556 Putative mono-oxygenase ydhR; Region: ydhR; cl07420 315730008557 Methyltransferase domain; Region: Methyltransf_31; pfam13847 315730008558 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730008559 S-adenosylmethionine binding site [chemical binding]; other site 315730008560 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 315730008561 Cytochrome P450; Region: p450; pfam00067 315730008562 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 315730008563 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 315730008564 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 315730008565 FAD binding pocket [chemical binding]; other site 315730008566 FAD binding motif [chemical binding]; other site 315730008567 catalytic residues [active] 315730008568 NAD binding pocket [chemical binding]; other site 315730008569 phosphate binding motif [ion binding]; other site 315730008570 beta-alpha-beta structure motif; other site 315730008571 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 315730008572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730008573 putative substrate translocation pore; other site 315730008574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730008575 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 315730008576 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 315730008577 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 315730008578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730008579 active site 315730008580 phosphorylation site [posttranslational modification] 315730008581 intermolecular recognition site; other site 315730008582 dimerization interface [polypeptide binding]; other site 315730008583 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730008584 DNA binding site [nucleotide binding] 315730008585 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730008586 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730008587 dimerization interface [polypeptide binding]; other site 315730008588 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730008589 dimer interface [polypeptide binding]; other site 315730008590 phosphorylation site [posttranslational modification] 315730008591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730008592 ATP binding site [chemical binding]; other site 315730008593 G-X-G motif; other site 315730008594 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 315730008595 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 315730008596 Methyltransferase domain; Region: Methyltransf_31; pfam13847 315730008597 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730008598 S-adenosylmethionine binding site [chemical binding]; other site 315730008599 D-cysteine desulfhydrase; Validated; Region: PRK03910 315730008600 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 315730008601 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 315730008602 catalytic residue [active] 315730008603 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 315730008604 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 315730008605 active site 315730008606 metal binding site [ion binding]; metal-binding site 315730008607 Domain of unknown function (DUF4073); Region: DUF4073; pfam13285 315730008608 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730008609 AMP-binding enzyme; Region: AMP-binding; cl15778 315730008610 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 315730008611 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315730008612 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 315730008613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730008614 NAD(P) binding site [chemical binding]; other site 315730008615 active site 315730008616 hypothetical protein; Provisional; Region: PRK06849 315730008617 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730008618 ATP-grasp domain; Region: ATP-grasp_4; cl03087 315730008619 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 315730008620 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 315730008621 dimer interface [polypeptide binding]; other site 315730008622 active site 315730008623 CoA binding pocket [chemical binding]; other site 315730008624 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 315730008625 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 315730008626 CAAX protease self-immunity; Region: Abi; cl00558 315730008627 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 315730008628 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315730008629 DNA binding residues [nucleotide binding] 315730008630 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 315730008631 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 315730008632 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730008633 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 315730008634 Walker A/P-loop; other site 315730008635 ATP binding site [chemical binding]; other site 315730008636 Q-loop/lid; other site 315730008637 ABC transporter signature motif; other site 315730008638 Walker B; other site 315730008639 D-loop; other site 315730008640 H-loop/switch region; other site 315730008641 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 315730008642 FtsX-like permease family; Region: FtsX; cl15850 315730008643 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730008644 dimerization interface [polypeptide binding]; other site 315730008645 putative DNA binding site [nucleotide binding]; other site 315730008646 Predicted transcriptional regulator [Transcription]; Region: COG2345 315730008647 putative Zn2+ binding site [ion binding]; other site 315730008648 H+ Antiporter protein; Region: 2A0121; TIGR00900 315730008649 DinB superfamily; Region: DinB_2; pfam12867 315730008650 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 315730008651 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730008652 dimerization interface [polypeptide binding]; other site 315730008653 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730008654 dimer interface [polypeptide binding]; other site 315730008655 phosphorylation site [posttranslational modification] 315730008656 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730008657 ATP binding site [chemical binding]; other site 315730008658 Mg2+ binding site [ion binding]; other site 315730008659 G-X-G motif; other site 315730008660 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730008661 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730008662 active site 315730008663 phosphorylation site [posttranslational modification] 315730008664 intermolecular recognition site; other site 315730008665 dimerization interface [polypeptide binding]; other site 315730008666 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730008667 DNA binding site [nucleotide binding] 315730008668 Uncharacterized conserved protein [Function unknown]; Region: COG1284 315730008669 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315730008670 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 315730008671 2TM domain; Region: 2TM; pfam13239 315730008672 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 315730008673 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 315730008674 putative dimer interface [polypeptide binding]; other site 315730008675 catalytic triad [active] 315730008676 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 315730008677 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 315730008678 dimer interaction site [polypeptide binding]; other site 315730008679 substrate-binding tunnel; other site 315730008680 active site 315730008681 catalytic site [active] 315730008682 substrate binding site [chemical binding]; other site 315730008683 Protein of unknown function (DUF1015); Region: DUF1015; cl01715 315730008684 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 315730008685 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730008686 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 315730008687 L-serine binding site [chemical binding]; other site 315730008688 ACT domain interface; other site 315730008689 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 315730008690 homodimer interface [polypeptide binding]; other site 315730008691 substrate-cofactor binding pocket; other site 315730008692 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730008693 catalytic residue [active] 315730008694 Domain of unknown function (DUF378); Region: DUF378; cl00943 315730008695 ADP-ribosyltransferase; Provisional; Region: alt; PHA02566 315730008696 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 315730008697 Proteins of 100 residues with WXG; Region: WXG100; cl02005 315730008698 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; cl15861 315730008699 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 315730008700 CAAX protease self-immunity; Region: Abi; cl00558 315730008701 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 315730008702 Erythromycin esterase; Region: Erythro_esteras; pfam05139 315730008703 Putative sensor; Region: Sensor; pfam13796 315730008704 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 315730008705 Histidine kinase; Region: HisKA_3; pfam07730 315730008706 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730008707 ATP binding site [chemical binding]; other site 315730008708 Mg2+ binding site [ion binding]; other site 315730008709 G-X-G motif; other site 315730008710 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 315730008711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730008712 active site 315730008713 phosphorylation site [posttranslational modification] 315730008714 intermolecular recognition site; other site 315730008715 dimerization interface [polypeptide binding]; other site 315730008716 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 315730008717 DNA binding residues [nucleotide binding] 315730008718 dimerization interface [polypeptide binding]; other site 315730008719 Penicillin amidase; Region: Penicil_amidase; pfam01804 315730008720 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 315730008721 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 315730008722 active site 315730008723 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 315730008724 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 315730008725 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730008726 Helix-turn-helix domains; Region: HTH; cl00088 315730008727 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 315730008728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730008729 putative substrate translocation pore; other site 315730008730 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 315730008731 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 315730008732 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 315730008733 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 315730008734 putative active site [active] 315730008735 putative metal binding site [ion binding]; other site 315730008736 NETI protein; Region: NETI; pfam14044 315730008737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730008738 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730008739 putative substrate translocation pore; other site 315730008740 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315730008741 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730008742 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315730008743 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315730008744 Helix-turn-helix domains; Region: HTH; cl00088 315730008745 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730008746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730008747 putative substrate translocation pore; other site 315730008748 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730008749 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 315730008750 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 315730008751 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 315730008752 DNA binding residues [nucleotide binding] 315730008753 dimer interface [polypeptide binding]; other site 315730008754 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 315730008755 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730008756 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730008757 hypothetical protein; Provisional; Region: PRK06770 315730008758 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730008759 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730008760 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315730008761 active site 315730008762 ATP binding site [chemical binding]; other site 315730008763 substrate binding site [chemical binding]; other site 315730008764 Arginine degradation protein (predicted deacylase) [Amino acid transport and metabolism]; Region: RocB; COG4187 315730008765 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 315730008766 putative metal binding site [ion binding]; other site 315730008767 putative dimer interface [polypeptide binding]; other site 315730008768 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315730008769 substrate binding site [chemical binding]; other site 315730008770 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 315730008771 active site 315730008772 metal binding site [ion binding]; metal-binding site 315730008773 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730008774 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 315730008775 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 315730008776 Uncharacterized conserved protein [Function unknown]; Region: COG4715 315730008777 SWIM zinc finger; Region: SWIM; cl15408 315730008778 YwiC-like protein; Region: YwiC; pfam14256 315730008779 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 315730008780 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 315730008781 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 315730008782 Walker A/P-loop; other site 315730008783 ATP binding site [chemical binding]; other site 315730008784 Q-loop/lid; other site 315730008785 ABC transporter signature motif; other site 315730008786 Walker B; other site 315730008787 D-loop; other site 315730008788 H-loop/switch region; other site 315730008789 Domain II of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. The...; Region: ABC_cobalt_CbiO_domain2; cd03226 315730008790 Walker A/P-loop; other site 315730008791 ATP binding site [chemical binding]; other site 315730008792 Q-loop/lid; other site 315730008793 ABC transporter signature motif; other site 315730008794 Walker B; other site 315730008795 D-loop; other site 315730008796 H-loop/switch region; other site 315730008797 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 315730008798 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 315730008799 Probable transposase; Region: OrfB_IS605; pfam01385 315730008800 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 315730008801 Cobalt transport protein; Region: CbiQ; cl00463 315730008802 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 315730008803 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 315730008804 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 315730008805 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 315730008806 Endonuclease I; Region: Endonuclease_1; cl01003 315730008807 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 315730008808 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730008809 non-specific DNA binding site [nucleotide binding]; other site 315730008810 salt bridge; other site 315730008811 sequence-specific DNA binding site [nucleotide binding]; other site 315730008812 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 315730008813 putative deacylase active site [active] 315730008814 histidyl-tRNA synthetase; Provisional; Region: PRK12420 315730008815 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 315730008816 dimer interface [polypeptide binding]; other site 315730008817 motif 1; other site 315730008818 active site 315730008819 motif 2; other site 315730008820 motif 3; other site 315730008821 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 315730008822 anticodon binding site; other site 315730008823 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 315730008824 active site 315730008825 domain interfaces; other site 315730008826 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 315730008827 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 315730008828 dimer interface [polypeptide binding]; other site 315730008829 active site 315730008830 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 315730008831 dimer interface [polypeptide binding]; other site 315730008832 FMN binding site [chemical binding]; other site 315730008833 Helix-turn-helix domains; Region: HTH; cl00088 315730008834 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 315730008835 classical (c) SDRs; Region: SDR_c; cd05233 315730008836 NAD(P) binding site [chemical binding]; other site 315730008837 active site 315730008838 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 315730008839 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 315730008840 Walker A/P-loop; other site 315730008841 ATP binding site [chemical binding]; other site 315730008842 Q-loop/lid; other site 315730008843 ABC transporter signature motif; other site 315730008844 Walker B; other site 315730008845 D-loop; other site 315730008846 H-loop/switch region; other site 315730008847 Protein of unknown function (DUF3796); Region: DUF3796; pfam12676 315730008848 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730008849 non-specific DNA binding site [nucleotide binding]; other site 315730008850 salt bridge; other site 315730008851 sequence-specific DNA binding site [nucleotide binding]; other site 315730008852 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 315730008853 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 315730008854 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 315730008855 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730008856 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 315730008857 DinB superfamily; Region: DinB_2; pfam12867 315730008858 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 315730008859 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730008860 motif II; other site 315730008861 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 315730008862 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 315730008863 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 315730008864 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730008865 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 315730008866 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 315730008867 nudix motif; other site 315730008868 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 315730008869 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730008870 putative metal binding site [ion binding]; other site 315730008871 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 315730008872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730008873 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730008874 putative substrate translocation pore; other site 315730008875 maltose O-acetyltransferase; Provisional; Region: PRK10092 315730008876 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 315730008877 active site 315730008878 substrate binding site [chemical binding]; other site 315730008879 trimer interface [polypeptide binding]; other site 315730008880 CoA binding site [chemical binding]; other site 315730008881 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 315730008882 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 315730008883 active site 315730008884 HIGH motif; other site 315730008885 dimer interface [polypeptide binding]; other site 315730008886 KMSKS motif; other site 315730008887 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464 315730008888 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 315730008889 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 315730008890 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 315730008891 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 315730008892 Domain of unknown function DUF20; Region: UPF0118; pfam01594 315730008893 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730008894 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 315730008895 Coenzyme A binding pocket [chemical binding]; other site 315730008896 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 315730008897 homodimer interaction site [polypeptide binding]; other site 315730008898 cofactor binding site; other site 315730008899 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 315730008900 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730008901 binding surface 315730008902 TPR motif; other site 315730008903 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 315730008904 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 315730008905 hypothetical protein; Provisional; Region: PRK04164 315730008906 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 315730008907 Domain of unknown function DUF21; Region: DUF21; pfam01595 315730008908 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 315730008909 Transporter associated domain; Region: CorC_HlyC; cl08393 315730008910 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 315730008911 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 315730008912 DNA binding residues [nucleotide binding] 315730008913 putative dimer interface [polypeptide binding]; other site 315730008914 EamA-like transporter family; Region: EamA; cl01037 315730008915 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 315730008916 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 315730008917 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 315730008918 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 315730008919 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 315730008920 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 315730008921 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 315730008922 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 315730008923 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 315730008924 N- and C-terminal domain interface [polypeptide binding]; other site 315730008925 putative active site [active] 315730008926 catalytic site [active] 315730008927 metal binding site [ion binding]; metal-binding site 315730008928 carbohydrate binding site [chemical binding]; other site 315730008929 ATP binding site [chemical binding]; other site 315730008930 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 315730008931 active site 315730008932 intersubunit interactions; other site 315730008933 catalytic residue [active] 315730008934 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730008935 6-phosphogluconate dehydrogenase (decarboxylating); Region: gnd_rel; TIGR00872 315730008936 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 315730008937 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 315730008938 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 315730008939 Domain of unknown function (DUF336); Region: DUF336; cl01249 315730008940 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315730008941 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315730008942 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 315730008943 nudix motif; other site 315730008944 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 315730008945 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 315730008946 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 315730008947 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 315730008948 short chain dehydrogenase; Provisional; Region: PRK12828 315730008949 NADP binding site [chemical binding]; other site 315730008950 homodimer interface [polypeptide binding]; other site 315730008951 active site 315730008952 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315730008953 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730008954 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 315730008955 AMP-binding enzyme; Region: AMP-binding; cl15778 315730008956 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315730008957 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 315730008958 Helix-turn-helix domains; Region: HTH; cl00088 315730008959 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730008960 dimerization interface [polypeptide binding]; other site 315730008961 putative DNA binding site [nucleotide binding]; other site 315730008962 putative Zn2+ binding site [ion binding]; other site 315730008963 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 315730008964 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 315730008965 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730008966 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 315730008967 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 315730008968 catalytic residues [active] 315730008969 catalytic nucleophile [active] 315730008970 Presynaptic Site I dimer interface [polypeptide binding]; other site 315730008971 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 315730008972 Synaptic Flat tetramer interface [polypeptide binding]; other site 315730008973 Synaptic Site I dimer interface [polypeptide binding]; other site 315730008974 DNA binding site [nucleotide binding] 315730008975 Helix-turn-helix domains; Region: HTH; cl00088 315730008976 DNA-binding interface [nucleotide binding]; DNA binding site 315730008977 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 315730008978 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 315730008979 TQXA domain; Region: TQXA_dom; TIGR03934 315730008980 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315730008981 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315730008982 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315730008983 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315730008984 Gram positive anchor; Region: Gram_pos_anchor; cl15427 315730008985 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 315730008986 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730008987 dimer interface [polypeptide binding]; other site 315730008988 phosphorylation site [posttranslational modification] 315730008989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730008990 ATP binding site [chemical binding]; other site 315730008991 Mg2+ binding site [ion binding]; other site 315730008992 G-X-G motif; other site 315730008993 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 315730008994 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 315730008995 nudix motif; other site 315730008996 Putative zinc-finger; Region: zf-HC2; cl15806 315730008997 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 315730008998 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 315730008999 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730009000 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730009001 DNA binding residues [nucleotide binding] 315730009002 CAAX protease self-immunity; Region: Abi; cl00558 315730009003 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730009004 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 315730009005 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730009006 dimerization interface [polypeptide binding]; other site 315730009007 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 315730009008 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730009009 dimer interface [polypeptide binding]; other site 315730009010 phosphorylation site [posttranslational modification] 315730009011 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730009012 ATP binding site [chemical binding]; other site 315730009013 Mg2+ binding site [ion binding]; other site 315730009014 G-X-G motif; other site 315730009015 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730009016 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730009017 active site 315730009018 phosphorylation site [posttranslational modification] 315730009019 intermolecular recognition site; other site 315730009020 dimerization interface [polypeptide binding]; other site 315730009021 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730009022 DNA binding site [nucleotide binding] 315730009023 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315730009024 Helix-turn-helix domains; Region: HTH; cl00088 315730009025 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315730009026 dimerization interface [polypeptide binding]; other site 315730009027 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730009028 NAD(P) binding site [chemical binding]; other site 315730009029 active site 315730009030 Protein of unknown function (DUF3963); Region: DUF3963; pfam13124 315730009031 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 315730009032 Predicted transcriptional regulator [Transcription]; Region: COG2378 315730009033 Helix-turn-helix domains; Region: HTH; cl00088 315730009034 WYL domain; Region: WYL; cl14852 315730009035 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 315730009036 Transmembrane amino acid transporter protein; Region: Aa_trans; cl15776 315730009037 ABC-2 type transporter; Region: ABC2_membrane; cl11417 315730009038 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 315730009039 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730009040 Walker A/P-loop; other site 315730009041 ATP binding site [chemical binding]; other site 315730009042 Q-loop/lid; other site 315730009043 ABC transporter signature motif; other site 315730009044 Walker B; other site 315730009045 D-loop; other site 315730009046 H-loop/switch region; other site 315730009047 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 315730009048 Helix-turn-helix domains; Region: HTH; cl00088 315730009049 hydroxylamine reductase; Provisional; Region: PRK12310 315730009050 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 315730009051 ACS interaction site; other site 315730009052 CODH interaction site; other site 315730009053 metal cluster binding site [ion binding]; other site 315730009054 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315730009055 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 315730009056 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 315730009057 hypothetical protein; Provisional; Region: PRK06771 315730009058 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730009059 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 315730009060 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730009061 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 315730009062 dimer interface [polypeptide binding]; other site 315730009063 ligand binding site [chemical binding]; other site 315730009064 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 315730009065 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 315730009066 ligand binding site [chemical binding]; other site 315730009067 flexible hinge region; other site 315730009068 Helix-turn-helix domains; Region: HTH; cl00088 315730009069 Protein of unknown function, DUF606; Region: DUF606; cl01273 315730009070 Protein of unknown function, DUF606; Region: DUF606; cl01273 315730009071 Bacteriophage T holin; Region: Phage_holin_T; pfam11031 315730009072 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315730009073 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 315730009074 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 315730009075 putative NAD(P) binding site [chemical binding]; other site 315730009076 dimer interface [polypeptide binding]; other site 315730009077 putative transport protein YifK; Provisional; Region: PRK10746 315730009078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730009079 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 315730009080 putative substrate translocation pore; other site 315730009081 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 315730009082 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 315730009083 active site 315730009084 aminotransferase; Validated; Region: PRK07678 315730009085 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315730009086 inhibitor-cofactor binding pocket; inhibition site 315730009087 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730009088 catalytic residue [active] 315730009089 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 315730009090 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 315730009091 tetrameric interface [polypeptide binding]; other site 315730009092 NAD binding site [chemical binding]; other site 315730009093 catalytic residues [active] 315730009094 Cupin domain; Region: Cupin_2; cl09118 315730009095 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 315730009096 MatE; Region: MatE; cl10513 315730009097 MatE; Region: MatE; cl10513 315730009098 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 315730009099 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 315730009100 tetramerization interface [polypeptide binding]; other site 315730009101 NAD(P) binding site [chemical binding]; other site 315730009102 catalytic residues [active] 315730009103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730009104 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 315730009105 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg1; cd04777 315730009106 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315730009107 DNA binding residues [nucleotide binding] 315730009108 putative dimer interface [polypeptide binding]; other site 315730009109 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 315730009110 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 315730009111 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 315730009112 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 315730009113 transmembrane helices; other site 315730009114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 315730009115 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315730009116 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730009117 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 315730009118 putative ligand binding residues [chemical binding]; other site 315730009119 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 315730009120 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 315730009121 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315730009122 ABC-ATPase subunit interface; other site 315730009123 dimer interface [polypeptide binding]; other site 315730009124 putative PBP binding regions; other site 315730009125 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315730009126 ABC-ATPase subunit interface; other site 315730009127 dimer interface [polypeptide binding]; other site 315730009128 putative PBP binding regions; other site 315730009129 Protein of unknown function (DUF817); Region: DUF817; cl01520 315730009130 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 315730009131 DinB superfamily; Region: DinB_2; pfam12867 315730009132 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 315730009133 DinB superfamily; Region: DinB_2; pfam12867 315730009134 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315730009135 Helix-turn-helix domains; Region: HTH; cl00088 315730009136 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315730009137 dimerization interface [polypeptide binding]; other site 315730009138 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 315730009139 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 315730009140 NADP binding site [chemical binding]; other site 315730009141 dimer interface [polypeptide binding]; other site 315730009142 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 315730009143 catalytic core [active] 315730009144 Predicted acetyltransferase [General function prediction only]; Region: COG3153 315730009145 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730009146 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 315730009147 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 315730009148 Walker A/P-loop; other site 315730009149 ATP binding site [chemical binding]; other site 315730009150 Q-loop/lid; other site 315730009151 ABC transporter signature motif; other site 315730009152 Walker B; other site 315730009153 D-loop; other site 315730009154 H-loop/switch region; other site 315730009155 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 315730009156 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 315730009157 active site 315730009158 Na/Ca binding site [ion binding]; other site 315730009159 catalytic site [active] 315730009160 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 315730009161 N-acetyltransferase; Region: Acetyltransf_2; cl00949 315730009162 oligoendopeptidase F; Region: pepF; TIGR00181 315730009163 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 315730009164 active site 315730009165 Zn binding site [ion binding]; other site 315730009166 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 315730009167 agmatine deiminase; Region: agmatine_aguA; TIGR03380 315730009168 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 315730009169 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 315730009170 active site 315730009171 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 315730009172 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 315730009173 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315730009174 DNA binding residues [nucleotide binding] 315730009175 drug binding residues [chemical binding]; other site 315730009176 dimer interface [polypeptide binding]; other site 315730009177 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 315730009178 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 315730009179 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 315730009180 Phosphate-starvation-inducible E; Region: PsiE; cl01264 315730009181 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 315730009182 agmatine deiminase; Region: agmatine_aguA; TIGR03380 315730009183 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730009184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730009185 putative substrate translocation pore; other site 315730009186 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730009187 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315730009188 Helix-turn-helix domains; Region: HTH; cl00088 315730009189 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 315730009190 putative dimerization interface [polypeptide binding]; other site 315730009191 Protein of unknown function (DUF3916); Region: DUF3916; pfam13079 315730009192 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 315730009193 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 315730009194 Proteins of 100 residues with WXG; Region: WXG100; cl02005 315730009195 FAD binding domain; Region: FAD_binding_3; pfam01494 315730009196 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730009197 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 315730009198 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 315730009199 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 315730009200 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315730009201 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730009202 TPR motif; other site 315730009203 binding surface 315730009204 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 315730009205 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 315730009206 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 315730009207 D-lactate dehydrogenase [cytochrome]; Region: PLN02805 315730009208 FAD binding domain; Region: FAD_binding_4; pfam01565 315730009209 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 315730009210 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730009211 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730009212 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 315730009213 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 315730009214 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 315730009215 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 315730009216 MgtC family; Region: MgtC; pfam02308 315730009217 Predicted acetyltransferase [General function prediction only]; Region: COG3981 315730009218 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 315730009219 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 315730009220 putative metal binding site [ion binding]; other site 315730009221 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 315730009222 active site 315730009223 metal binding site [ion binding]; metal-binding site 315730009224 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 315730009225 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 315730009226 substrate binding pocket [chemical binding]; other site 315730009227 membrane-bound complex binding site; other site 315730009228 hinge residues; other site 315730009229 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 315730009230 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 315730009231 Walker A/P-loop; other site 315730009232 ATP binding site [chemical binding]; other site 315730009233 Q-loop/lid; other site 315730009234 ABC transporter signature motif; other site 315730009235 Walker B; other site 315730009236 D-loop; other site 315730009237 H-loop/switch region; other site 315730009238 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 315730009239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730009240 dimer interface [polypeptide binding]; other site 315730009241 conserved gate region; other site 315730009242 putative PBP binding loops; other site 315730009243 ABC-ATPase subunit interface; other site 315730009244 VanW like protein; Region: VanW; pfam04294 315730009245 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 315730009246 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 315730009247 exonuclease; Provisional; Region: PRK06722 315730009248 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 315730009249 active site 315730009250 substrate binding site [chemical binding]; other site 315730009251 catalytic site [active] 315730009252 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 315730009253 DNA-binding site [nucleotide binding]; DNA binding site 315730009254 RNA-binding motif; other site 315730009255 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 315730009256 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 315730009257 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 315730009258 nudix motif; other site 315730009259 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 315730009260 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 315730009261 trimer interface [polypeptide binding]; other site 315730009262 active site 315730009263 substrate binding site [chemical binding]; other site 315730009264 CoA binding site [chemical binding]; other site 315730009265 Fibronectin type III-like domain; Region: Fn3-like; cl15273 315730009266 Fibronectin type III-like domain; Region: Fn3-like; cl15273 315730009267 Fibronectin type III-like domain; Region: Fn3-like; cl15273 315730009268 Fibronectin type III-like domain; Region: Fn3-like; cl15273 315730009269 Fibronectin type III-like domain; Region: Fn3-like; cl15273 315730009270 Fibronectin type III-like domain; Region: Fn3-like; cl15273 315730009271 Fibronectin type III-like domain; Region: Fn3-like; cl15273 315730009272 Fibronectin type III-like domain; Region: Fn3-like; cl15273 315730009273 Fibronectin type III-like domain; Region: Fn3-like; cl15273 315730009274 Fibronectin type III-like domain; Region: Fn3-like; cl15273 315730009275 Fibronectin type III-like domain; Region: Fn3-like; cl15273 315730009276 Fibronectin type III-like domain; Region: Fn3-like; cl15273 315730009277 Fibronectin type III-like domain; Region: Fn3-like; cl15273 315730009278 Fibronectin type III-like domain; Region: Fn3-like; cl15273 315730009279 Fibronectin type III-like domain; Region: Fn3-like; cl15273 315730009280 short chain dehydrogenase; Provisional; Region: PRK06924 315730009281 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 315730009282 NADP binding site [chemical binding]; other site 315730009283 homodimer interface [polypeptide binding]; other site 315730009284 active site 315730009285 Predicted acetyltransferase [General function prediction only]; Region: COG3393 315730009286 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730009287 argininosuccinate lyase; Provisional; Region: PRK06705 315730009288 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 315730009289 active sites [active] 315730009290 tetramer interface [polypeptide binding]; other site 315730009291 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 315730009292 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 315730009293 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730009294 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 315730009295 active site 315730009296 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 315730009297 Sodium:solute symporter family; Region: SSF; cl00456 315730009298 Protein of unknown function (DUF997); Region: DUF997; cl01614 315730009299 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 315730009300 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 315730009301 NAD(P) binding site [chemical binding]; other site 315730009302 catalytic residues [active] 315730009303 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 315730009304 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 315730009305 NAD(P) binding site [chemical binding]; other site 315730009306 homotetramer interface [polypeptide binding]; other site 315730009307 homodimer interface [polypeptide binding]; other site 315730009308 active site 315730009309 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 315730009310 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 315730009311 Divergent PAP2 family; Region: DUF212; cl00855 315730009312 Predicted permeases [General function prediction only]; Region: RarD; COG2962 315730009313 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 315730009314 Tubulin like; Region: Tubulin_2; pfam13809 315730009315 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 315730009316 metal ion-dependent adhesion site (MIDAS); other site 315730009317 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730009318 S-adenosylmethionine binding site [chemical binding]; other site 315730009319 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 315730009320 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 315730009321 peptide binding site [polypeptide binding]; other site 315730009322 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 315730009323 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 315730009324 peptide binding site [polypeptide binding]; other site 315730009325 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 315730009326 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 315730009327 peptide binding site [polypeptide binding]; other site 315730009328 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 315730009329 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 315730009330 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730009331 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730009332 DNA binding residues [nucleotide binding] 315730009333 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 315730009334 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 315730009335 putative active site [active] 315730009336 putative metal-binding site [ion binding]; other site 315730009337 ABC-2 type transporter; Region: ABC2_membrane; cl11417 315730009338 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315730009339 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 315730009340 Walker A/P-loop; other site 315730009341 ATP binding site [chemical binding]; other site 315730009342 Q-loop/lid; other site 315730009343 ABC transporter signature motif; other site 315730009344 Walker B; other site 315730009345 D-loop; other site 315730009346 H-loop/switch region; other site 315730009347 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730009348 Helix-turn-helix domains; Region: HTH; cl00088 315730009349 Predicted transcriptional regulator [Transcription]; Region: COG2378 315730009350 Helix-turn-helix domains; Region: HTH; cl00088 315730009351 WYL domain; Region: WYL; cl14852 315730009352 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 315730009353 dimer interface [polypeptide binding]; other site 315730009354 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730009355 putative oxidoreductase; Provisional; Region: PRK11579 315730009356 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730009357 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 315730009358 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 315730009359 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 315730009360 CAP-like domain; other site 315730009361 active site 315730009362 primary dimer interface [polypeptide binding]; other site 315730009363 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315730009364 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315730009365 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315730009366 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 315730009367 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 315730009368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730009369 ATP binding site [chemical binding]; other site 315730009370 Mg2+ binding site [ion binding]; other site 315730009371 G-X-G motif; other site 315730009372 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 315730009373 anchoring element; other site 315730009374 dimer interface [polypeptide binding]; other site 315730009375 ATP binding site [chemical binding]; other site 315730009376 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 315730009377 active site 315730009378 putative metal-binding site [ion binding]; other site 315730009379 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 315730009380 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730009381 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 315730009382 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 315730009383 protein binding site [polypeptide binding]; other site 315730009384 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730009385 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730009386 active site 315730009387 phosphorylation site [posttranslational modification] 315730009388 intermolecular recognition site; other site 315730009389 dimerization interface [polypeptide binding]; other site 315730009390 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730009391 DNA binding site [nucleotide binding] 315730009392 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 315730009393 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 315730009394 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 315730009395 Class III ribonucleotide reductase; Region: RNR_III; cd01675 315730009396 effector binding site; other site 315730009397 active site 315730009398 Zn binding site [ion binding]; other site 315730009399 glycine loop; other site 315730009400 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 315730009401 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 315730009402 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 315730009403 active site 315730009404 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 315730009405 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 315730009406 putative peptidoglycan binding site; other site 315730009407 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 315730009408 putative peptidoglycan binding site; other site 315730009409 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 315730009410 active site 315730009411 Small acid-soluble spore protein N family; Region: SspN; cl11659 315730009412 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 315730009413 DNA polymerase III subunit epsilon; Validated; Region: PRK06807 315730009414 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 315730009415 active site 315730009416 substrate binding site [chemical binding]; other site 315730009417 catalytic site [active] 315730009418 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 315730009419 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 315730009420 catalytic residues [active] 315730009421 YmzC-like protein; Region: YmzC; pfam14157 315730009422 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 315730009423 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 315730009424 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730009425 Walker A/P-loop; other site 315730009426 ATP binding site [chemical binding]; other site 315730009427 Q-loop/lid; other site 315730009428 ABC transporter signature motif; other site 315730009429 Walker B; other site 315730009430 D-loop; other site 315730009431 H-loop/switch region; other site 315730009432 aconitate hydratase; Validated; Region: PRK09277 315730009433 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 315730009434 substrate binding site [chemical binding]; other site 315730009435 ligand binding site [chemical binding]; other site 315730009436 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 315730009437 substrate binding site [chemical binding]; other site 315730009438 Small acid-soluble spore protein O family; Region: SspO; cl07943 315730009439 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 315730009440 NodB motif; other site 315730009441 active site 315730009442 catalytic site [active] 315730009443 metal binding site [ion binding]; metal-binding site 315730009444 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 315730009445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730009446 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730009447 putative substrate translocation pore; other site 315730009448 alanyl-tRNA synthetase; Provisional; Region: alaS; PRK13902 315730009449 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 315730009450 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 315730009451 nudix motif; other site 315730009452 SAP domain; Region: SAP; cl02640 315730009453 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 315730009454 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 315730009455 dimer interface [polypeptide binding]; other site 315730009456 active site 315730009457 acyl-CoA synthetase; Validated; Region: PRK07638 315730009458 AMP-binding enzyme; Region: AMP-binding; cl15778 315730009459 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315730009460 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 315730009461 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 315730009462 AMP-binding enzyme; Region: AMP-binding; cl15778 315730009463 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315730009464 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 315730009465 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730009466 non-specific DNA binding site [nucleotide binding]; other site 315730009467 salt bridge; other site 315730009468 sequence-specific DNA binding site [nucleotide binding]; other site 315730009469 S-layer homology domain; Region: SLH; pfam00395 315730009470 S-layer homology domain; Region: SLH; pfam00395 315730009471 S-layer homology domain; Region: SLH; pfam00395 315730009472 Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278 315730009473 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 315730009474 amidase catalytic site [active] 315730009475 Zn binding residues [ion binding]; other site 315730009476 substrate binding site [chemical binding]; other site 315730009477 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 315730009478 active site 315730009479 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315730009480 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 315730009481 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730009482 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 315730009483 dimer interface [polypeptide binding]; other site 315730009484 putative metal binding site [ion binding]; other site 315730009485 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315730009486 PAS domain; Region: PAS_9; pfam13426 315730009487 putative active site [active] 315730009488 heme pocket [chemical binding]; other site 315730009489 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 315730009490 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 315730009491 putative active site [active] 315730009492 heme pocket [chemical binding]; other site 315730009493 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730009494 dimer interface [polypeptide binding]; other site 315730009495 phosphorylation site [posttranslational modification] 315730009496 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730009497 ATP binding site [chemical binding]; other site 315730009498 Mg2+ binding site [ion binding]; other site 315730009499 G-X-G motif; other site 315730009500 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 315730009501 Phosphotransferase enzyme family; Region: APH; pfam01636 315730009502 active site 315730009503 substrate binding site [chemical binding]; other site 315730009504 ATP binding site [chemical binding]; other site 315730009505 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315730009506 substrate binding site [chemical binding]; other site 315730009507 Predicted esterase [General function prediction only]; Region: COG0400 315730009508 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315730009509 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 315730009510 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730009511 Zn binding site [ion binding]; other site 315730009512 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 315730009513 Zn binding site [ion binding]; other site 315730009514 Sodium:solute symporter family; Region: SSF; cl00456 315730009515 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 315730009516 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 315730009517 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 315730009518 active site 315730009519 FMN binding site [chemical binding]; other site 315730009520 substrate binding site [chemical binding]; other site 315730009521 3Fe-4S cluster binding site [ion binding]; other site 315730009522 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 315730009523 FMN binding site [chemical binding]; other site 315730009524 active site 315730009525 substrate binding site [chemical binding]; other site 315730009526 catalytic residue [active] 315730009527 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 315730009528 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 315730009529 catalytic Zn binding site [ion binding]; other site 315730009530 NAD binding site [chemical binding]; other site 315730009531 structural Zn binding site [ion binding]; other site 315730009532 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 315730009533 Arginase family; Region: Arginase; cl00306 315730009534 imidazolonepropionase; Validated; Region: PRK09356 315730009535 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 315730009536 active site 315730009537 urocanate hydratase; Provisional; Region: PRK05414 315730009538 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 315730009539 active sites [active] 315730009540 tetramer interface [polypeptide binding]; other site 315730009541 HutP; Region: HutP; cl07944 315730009542 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730009543 S-adenosylmethionine binding site [chemical binding]; other site 315730009544 DJ-1 family protein; Region: not_thiJ; TIGR01383 315730009545 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 315730009546 conserved cys residue [active] 315730009547 AAA domain; Region: AAA_28; pfam13521 315730009548 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730009549 active site 315730009550 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 315730009551 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 315730009552 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 315730009553 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 315730009554 EamA-like transporter family; Region: EamA; cl01037 315730009555 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 315730009556 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 315730009557 metal binding site [ion binding]; metal-binding site 315730009558 dimer interface [polypeptide binding]; other site 315730009559 ABC-2 type transporter; Region: ABC2_membrane; cl11417 315730009560 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315730009561 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730009562 Walker A/P-loop; other site 315730009563 ATP binding site [chemical binding]; other site 315730009564 Q-loop/lid; other site 315730009565 ABC transporter signature motif; other site 315730009566 Walker B; other site 315730009567 D-loop; other site 315730009568 H-loop/switch region; other site 315730009569 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 315730009570 Helix-turn-helix domains; Region: HTH; cl00088 315730009571 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 315730009572 putative dimerization interface [polypeptide binding]; other site 315730009573 putative substrate binding pocket [chemical binding]; other site 315730009574 LrgA family; Region: LrgA; cl00608 315730009575 LrgB-like family; Region: LrgB; cl00596 315730009576 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 315730009577 nudix motif; other site 315730009578 Domain of unknown function (DUF3903); Region: DUF3903; pfam13043 315730009579 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 315730009580 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 315730009581 amidase catalytic site [active] 315730009582 Zn binding residues [ion binding]; other site 315730009583 substrate binding site [chemical binding]; other site 315730009584 S-layer homology domain; Region: SLH; pfam00395 315730009585 S-layer homology domain; Region: SLH; pfam00395 315730009586 S-layer homology domain; Region: SLH; pfam00395 315730009587 Nuclease-related domain; Region: NERD; pfam08378 315730009588 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 315730009589 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 315730009590 active site 315730009591 Bacterial SH3 domain; Region: SH3_3; cl02551 315730009592 Bacterial SH3 domain; Region: SH3_3; cl02551 315730009593 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 315730009594 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 315730009595 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 315730009596 Walker A/P-loop; other site 315730009597 ATP binding site [chemical binding]; other site 315730009598 Q-loop/lid; other site 315730009599 ABC transporter signature motif; other site 315730009600 Walker B; other site 315730009601 D-loop; other site 315730009602 H-loop/switch region; other site 315730009603 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 315730009604 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 315730009605 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730009606 Walker A/P-loop; other site 315730009607 ATP binding site [chemical binding]; other site 315730009608 Q-loop/lid; other site 315730009609 ABC transporter signature motif; other site 315730009610 Walker B; other site 315730009611 D-loop; other site 315730009612 H-loop/switch region; other site 315730009613 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 315730009614 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 315730009615 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 315730009616 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 315730009617 TPP-binding site [chemical binding]; other site 315730009618 dimer interface [polypeptide binding]; other site 315730009619 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 315730009620 PYR/PP interface [polypeptide binding]; other site 315730009621 dimer interface [polypeptide binding]; other site 315730009622 TPP binding site [chemical binding]; other site 315730009623 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 315730009624 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 315730009625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730009626 dimer interface [polypeptide binding]; other site 315730009627 conserved gate region; other site 315730009628 ABC-ATPase subunit interface; other site 315730009629 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 315730009630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 315730009631 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 315730009632 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 315730009633 Walker A/P-loop; other site 315730009634 ATP binding site [chemical binding]; other site 315730009635 Q-loop/lid; other site 315730009636 ABC transporter signature motif; other site 315730009637 Walker B; other site 315730009638 D-loop; other site 315730009639 H-loop/switch region; other site 315730009640 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 315730009641 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 315730009642 substrate binding pocket [chemical binding]; other site 315730009643 membrane-bound complex binding site; other site 315730009644 hinge residues; other site 315730009645 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 315730009646 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 315730009647 active site 315730009648 metal binding site [ion binding]; metal-binding site 315730009649 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 315730009650 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 315730009651 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 315730009652 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 315730009653 catalytic residues [active] 315730009654 catalytic nucleophile [active] 315730009655 LexA repressor; Validated; Region: PRK00215 315730009656 Helix-turn-helix domains; Region: HTH; cl00088 315730009657 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 315730009658 Catalytic site [active] 315730009659 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 315730009660 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 315730009661 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 315730009662 Helix-turn-helix domains; Region: HTH; cl00088 315730009663 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 315730009664 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730009665 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 315730009666 Walker A/P-loop; other site 315730009667 ATP binding site [chemical binding]; other site 315730009668 Q-loop/lid; other site 315730009669 ABC transporter signature motif; other site 315730009670 Walker B; other site 315730009671 D-loop; other site 315730009672 H-loop/switch region; other site 315730009673 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 315730009674 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 315730009675 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 315730009676 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 315730009677 active site 315730009678 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 315730009679 active site 315730009680 dimer interface [polypeptide binding]; other site 315730009681 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 315730009682 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 315730009683 Ligand Binding Site [chemical binding]; other site 315730009684 Molecular Tunnel; other site 315730009685 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 315730009686 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 315730009687 inhibitor-cofactor binding pocket; inhibition site 315730009688 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730009689 catalytic residue [active] 315730009690 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 315730009691 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 315730009692 putative trimer interface [polypeptide binding]; other site 315730009693 putative CoA binding site [chemical binding]; other site 315730009694 Bacterial sugar transferase; Region: Bac_transf; cl00939 315730009695 Right handed beta helix region; Region: Beta_helix; pfam13229 315730009696 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 315730009697 Domain of unknown function (DUF1792); Region: DUF1792; cl07392 315730009698 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 315730009699 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 315730009700 active site 315730009701 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 315730009702 putative ADP-binding pocket [chemical binding]; other site 315730009703 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315730009704 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 315730009705 putative ADP-binding pocket [chemical binding]; other site 315730009706 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 315730009707 putative ADP-binding pocket [chemical binding]; other site 315730009708 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315730009709 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 315730009710 putative ADP-binding pocket [chemical binding]; other site 315730009711 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315730009712 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 315730009713 putative ADP-binding pocket [chemical binding]; other site 315730009714 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 315730009715 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 315730009716 active site 315730009717 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315730009718 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 315730009719 putative ADP-binding pocket [chemical binding]; other site 315730009720 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 315730009721 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315730009722 putative ADP-binding pocket [chemical binding]; other site 315730009723 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 315730009724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730009725 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 315730009726 NAD(P) binding site [chemical binding]; other site 315730009727 homodimer interface [polypeptide binding]; other site 315730009728 substrate binding site [chemical binding]; other site 315730009729 active site 315730009730 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 315730009731 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730009732 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 315730009733 Chain length determinant protein; Region: Wzz; cl15801 315730009734 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 315730009735 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 315730009736 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 315730009737 amidase catalytic site [active] 315730009738 Zn binding residues [ion binding]; other site 315730009739 substrate binding site [chemical binding]; other site 315730009740 Bacterial SH3 domain; Region: SH3_3; cl02551 315730009741 Bacterial SH3 domain; Region: SH3_3; cl02551 315730009742 Holin family; Region: Phage_holin_4; cl01989 315730009743 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 315730009744 Reovirus sigma C capsid protein; Region: Reo_sigmaC; pfam04582 315730009745 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 315730009746 Phage-related protein [Function unknown]; Region: COG4722; cl15832 315730009747 Phage-related protein [Function unknown]; Region: COG4722; cl15832 315730009748 Phage-related minor tail protein [Function unknown]; Region: COG5280 315730009749 membrane protein P6; Region: PHA01399 315730009750 membrane protein P6; Region: PHA01399 315730009751 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 315730009752 Phage-related minor tail protein [Function unknown]; Region: COG5280 315730009753 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 315730009754 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 315730009755 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 315730009756 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 315730009757 Phage capsid family; Region: Phage_capsid; pfam05065 315730009758 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 315730009759 Phage-related protein [Function unknown]; Region: COG4695; cl01923 315730009760 Phage portal protein; Region: Phage_portal; pfam04860 315730009761 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 315730009762 Phage Terminase; Region: Terminase_1; pfam03354 315730009763 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 315730009764 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 315730009765 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 315730009766 PLD-like domain; Region: PLDc_2; pfam13091 315730009767 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138 315730009768 putative active site [active] 315730009769 catalytic site [active] 315730009770 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138 315730009771 putative active site [active] 315730009772 catalytic site [active] 315730009773 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 315730009774 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 315730009775 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 315730009776 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 315730009777 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730009778 AAA domain; Region: AAA_21; pfam13304 315730009779 Walker A/P-loop; other site 315730009780 ATP binding site [chemical binding]; other site 315730009781 positive control sigma-like factor; Validated; Region: PRK06930 315730009782 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730009783 DNA binding residues [nucleotide binding] 315730009784 AAA ATPase domain; Region: AAA_15; pfam13175 315730009785 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730009786 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 315730009787 Thymidylate synthase complementing protein; Region: Thy1; cl03630 315730009788 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 315730009789 cofactor binding site; other site 315730009790 DNA binding site [nucleotide binding] 315730009791 substrate interaction site [chemical binding]; other site 315730009792 Dimeric dUTPase [Carbohydrate transport and metabolism]; Region: COG4508 315730009793 dUTPase; Region: dUTPase_2; pfam08761 315730009794 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27); Region: Auto_anti-p27; cl00713 315730009795 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730009796 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 315730009797 Walker A motif; other site 315730009798 ATP binding site [chemical binding]; other site 315730009799 Walker B motif; other site 315730009800 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; cl09752 315730009801 Protein of unknown function (DUF1071); Region: DUF1071; pfam06378 315730009802 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 315730009803 Domain of unknown function (DUF771); Region: DUF771; cl09962 315730009804 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 315730009805 ORF6C domain; Region: ORF6C; pfam10552 315730009806 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730009807 sequence-specific DNA binding site [nucleotide binding]; other site 315730009808 salt bridge; other site 315730009809 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 315730009810 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730009811 non-specific DNA binding site [nucleotide binding]; other site 315730009812 salt bridge; other site 315730009813 sequence-specific DNA binding site [nucleotide binding]; other site 315730009814 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 315730009815 Domain of unknown function (DUF955); Region: DUF955; cl01076 315730009816 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 315730009817 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 315730009818 Int/Topo IB signature motif; other site 315730009819 glutamine synthetase, type I; Region: GlnA; TIGR00653 315730009820 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 315730009821 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 315730009822 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 315730009823 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315730009824 DNA binding residues [nucleotide binding] 315730009825 putative dimer interface [polypeptide binding]; other site 315730009826 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 315730009827 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 315730009828 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 315730009829 catalytic residue [active] 315730009830 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 315730009831 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 315730009832 HflX GTPase family; Region: HflX; cd01878 315730009833 G1 box; other site 315730009834 GTP/Mg2+ binding site [chemical binding]; other site 315730009835 Switch I region; other site 315730009836 G2 box; other site 315730009837 G3 box; other site 315730009838 Switch II region; other site 315730009839 G4 box; other site 315730009840 G5 box; other site 315730009841 Predicted membrane protein [Function unknown]; Region: COG2860 315730009842 UPF0126 domain; Region: UPF0126; pfam03458 315730009843 UPF0126 domain; Region: UPF0126; pfam03458 315730009844 stage V sporulation protein K; Region: spore_V_K; TIGR02881 315730009845 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730009846 Walker A motif; other site 315730009847 ATP binding site [chemical binding]; other site 315730009848 Walker B motif; other site 315730009849 arginine finger; other site 315730009850 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 315730009851 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 315730009852 DNA binding site [nucleotide binding] 315730009853 active site 315730009854 Int/Topo IB signature motif; other site 315730009855 catalytic residues [active] 315730009856 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 315730009857 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 315730009858 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 315730009859 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 315730009860 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 315730009861 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 315730009862 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 315730009863 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 315730009864 Sm1 motif; other site 315730009865 intra - hexamer interaction site; other site 315730009866 inter - hexamer interaction site [polypeptide binding]; other site 315730009867 nucleotide binding pocket [chemical binding]; other site 315730009868 Sm2 motif; other site 315730009869 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730009870 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 315730009871 Bacterial SH3 domain; Region: SH3_3; cl02551 315730009872 Bacterial SH3 domain; Region: SH3_3; cl02551 315730009873 3D domain; Region: 3D; cl01439 315730009874 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 315730009875 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 315730009876 active site 315730009877 phosphorylation site [posttranslational modification] 315730009878 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 315730009879 P-loop; other site 315730009880 active site 315730009881 phosphorylation site [posttranslational modification] 315730009882 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 315730009883 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 315730009884 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 315730009885 putative substrate binding site [chemical binding]; other site 315730009886 putative ATP binding site [chemical binding]; other site 315730009887 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 315730009888 Helix-turn-helix domains; Region: HTH; cl00088 315730009889 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 315730009890 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 315730009891 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 315730009892 dimer interface [polypeptide binding]; other site 315730009893 active site 315730009894 metal binding site [ion binding]; metal-binding site 315730009895 Protein of unknown function (DUF420); Region: DUF420; cl00989 315730009896 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 315730009897 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 315730009898 Glyco_18 domain; Region: Glyco_18; smart00636 315730009899 putative active site [active] 315730009900 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 315730009901 amidohydrolase; Region: amidohydrolases; TIGR01891 315730009902 metal binding site [ion binding]; metal-binding site 315730009903 dimer interface [polypeptide binding]; other site 315730009904 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 315730009905 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 315730009906 putative active site [active] 315730009907 putative metal binding site [ion binding]; other site 315730009908 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 315730009909 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 315730009910 IHF dimer interface [polypeptide binding]; other site 315730009911 IHF - DNA interface [nucleotide binding]; other site 315730009912 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 315730009913 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730009914 Coenzyme A binding pocket [chemical binding]; other site 315730009915 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 315730009916 metal-binding site [ion binding] 315730009917 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 315730009918 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 315730009919 metal-binding site [ion binding] 315730009920 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 315730009921 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 315730009922 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 315730009923 metal-binding site [ion binding] 315730009924 Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157 315730009925 putative homotetramer interface [polypeptide binding]; other site 315730009926 putative homodimer interface [polypeptide binding]; other site 315730009927 allosteric switch controlling residues; other site 315730009928 putative metal binding site [ion binding]; other site 315730009929 putative homodimer-homodimer interface [polypeptide binding]; other site 315730009930 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 315730009931 DNA binding residues [nucleotide binding] 315730009932 dimerization interface [polypeptide binding]; other site 315730009933 Methyltransferase domain; Region: Methyltransf_31; pfam13847 315730009934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730009935 S-adenosylmethionine binding site [chemical binding]; other site 315730009936 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315730009937 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 315730009938 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 315730009939 Walker A/P-loop; other site 315730009940 ATP binding site [chemical binding]; other site 315730009941 Q-loop/lid; other site 315730009942 ABC transporter signature motif; other site 315730009943 Walker B; other site 315730009944 D-loop; other site 315730009945 H-loop/switch region; other site 315730009946 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 315730009947 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315730009948 ABC-ATPase subunit interface; other site 315730009949 dimer interface [polypeptide binding]; other site 315730009950 putative PBP binding regions; other site 315730009951 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315730009952 ABC-ATPase subunit interface; other site 315730009953 dimer interface [polypeptide binding]; other site 315730009954 putative PBP binding regions; other site 315730009955 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 315730009956 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 315730009957 putative ligand binding residues [chemical binding]; other site 315730009958 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 315730009959 active site 315730009960 DNA binding site [nucleotide binding] 315730009961 putative phosphate binding site [ion binding]; other site 315730009962 putative catalytic site [active] 315730009963 metal binding site A [ion binding]; metal-binding site 315730009964 AP binding site [nucleotide binding]; other site 315730009965 metal binding site B [ion binding]; metal-binding site 315730009966 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 315730009967 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 315730009968 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315730009969 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315730009970 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 315730009971 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 315730009972 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 315730009973 DNA binding site [nucleotide binding] 315730009974 active site 315730009975 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 315730009976 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 315730009977 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 315730009978 minor groove reading motif; other site 315730009979 helix-hairpin-helix signature motif; other site 315730009980 substrate binding pocket [chemical binding]; other site 315730009981 active site 315730009982 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 315730009983 peptidase T; Region: peptidase-T; TIGR01882 315730009984 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 315730009985 metal binding site [ion binding]; metal-binding site 315730009986 dimer interface [polypeptide binding]; other site 315730009987 Predicted membrane protein [Function unknown]; Region: COG2364 315730009988 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315730009989 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 315730009990 catalytic core [active] 315730009991 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730009992 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 315730009993 active site 315730009994 metal binding site [ion binding]; metal-binding site 315730009995 PAS domain S-box; Region: sensory_box; TIGR00229 315730009996 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 315730009997 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 315730009998 metal binding site [ion binding]; metal-binding site 315730009999 active site 315730010000 I-site; other site 315730010001 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 315730010002 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 315730010003 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 315730010004 active site 315730010005 homodimer interface [polypeptide binding]; other site 315730010006 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730010007 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 315730010008 NAD(P) binding site [chemical binding]; other site 315730010009 active site 315730010010 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 315730010011 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 315730010012 NAD(P) binding site [chemical binding]; other site 315730010013 homodimer interface [polypeptide binding]; other site 315730010014 substrate binding site [chemical binding]; other site 315730010015 active site 315730010016 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 315730010017 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 315730010018 LrgB-like family; Region: LrgB; cl00596 315730010019 LrgA family; Region: LrgA; cl00608 315730010020 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 315730010021 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730010022 DNA-binding site [nucleotide binding]; DNA binding site 315730010023 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315730010024 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730010025 homodimer interface [polypeptide binding]; other site 315730010026 catalytic residue [active] 315730010027 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315730010028 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730010029 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 315730010030 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 315730010031 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730010032 DNA-binding site [nucleotide binding]; DNA binding site 315730010033 UTRA domain; Region: UTRA; cl01230 315730010034 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 315730010035 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 315730010036 active site 315730010037 catalytic site [active] 315730010038 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 315730010039 putative peptidoglycan binding site; other site 315730010040 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 315730010041 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 315730010042 putative peptidoglycan binding site; other site 315730010043 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 315730010044 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 315730010045 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730010046 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 315730010047 Sulfatase; Region: Sulfatase; cl10460 315730010048 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730010049 binding surface 315730010050 TPR motif; other site 315730010051 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730010052 G1 box; other site 315730010053 GTP/Mg2+ binding site [chemical binding]; other site 315730010054 G2 box; other site 315730010055 Switch I region; other site 315730010056 G3 box; other site 315730010057 Switch II region; other site 315730010058 G4 box; other site 315730010059 G5 box; other site 315730010060 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 315730010061 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 315730010062 active site 315730010063 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 315730010064 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730010065 ATP binding site [chemical binding]; other site 315730010066 Mg2+ binding site [ion binding]; other site 315730010067 G-X-G motif; other site 315730010068 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 315730010069 ATP binding site [chemical binding]; other site 315730010070 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 315730010071 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 315730010072 MutS domain I; Region: MutS_I; pfam01624 315730010073 MutS domain II; Region: MutS_II; pfam05188 315730010074 MutS family domain IV; Region: MutS_IV; pfam05190 315730010075 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 315730010076 Walker A/P-loop; other site 315730010077 ATP binding site [chemical binding]; other site 315730010078 Q-loop/lid; other site 315730010079 ABC transporter signature motif; other site 315730010080 Walker B; other site 315730010081 D-loop; other site 315730010082 H-loop/switch region; other site 315730010083 Outer spore coat protein E (CotE); Region: CotE; pfam10628 315730010084 Protein of unknown function (DUF964); Region: DUF964; cl01483 315730010085 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 315730010086 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 315730010087 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315730010088 FeS/SAM binding site; other site 315730010089 TRAM domain; Region: TRAM; cl01282 315730010090 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 315730010091 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 315730010092 TPP-binding site [chemical binding]; other site 315730010093 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 315730010094 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 315730010095 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 315730010096 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 315730010097 dimer interface [polypeptide binding]; other site 315730010098 PYR/PP interface [polypeptide binding]; other site 315730010099 TPP binding site [chemical binding]; other site 315730010100 substrate binding site [chemical binding]; other site 315730010101 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 315730010102 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 315730010103 active site 315730010104 dimer interface [polypeptide binding]; other site 315730010105 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 315730010106 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 315730010107 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 315730010108 putative active site [active] 315730010109 metal binding site [ion binding]; metal-binding site 315730010110 homodimer binding site [polypeptide binding]; other site 315730010111 phosphodiesterase; Provisional; Region: PRK12704 315730010112 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730010113 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 315730010114 recombinase A; Provisional; Region: recA; PRK09354 315730010115 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 315730010116 hexamer interface [polypeptide binding]; other site 315730010117 Walker A motif; other site 315730010118 ATP binding site [chemical binding]; other site 315730010119 Walker B motif; other site 315730010120 competence damage-inducible protein A; Provisional; Region: PRK00549 315730010121 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 315730010122 putative MPT binding site; other site 315730010123 Competence-damaged protein; Region: CinA; cl00666 315730010124 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 315730010125 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 315730010126 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 315730010127 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 315730010128 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 315730010129 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 315730010130 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 315730010131 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 315730010132 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730010133 NAD(P) binding site [chemical binding]; other site 315730010134 active site 315730010135 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 315730010136 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 315730010137 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 315730010138 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 315730010139 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 315730010140 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 315730010141 TM-ABC transporter signature motif; other site 315730010142 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 315730010143 TM-ABC transporter signature motif; other site 315730010144 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 315730010145 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730010146 Walker A/P-loop; other site 315730010147 ATP binding site [chemical binding]; other site 315730010148 Q-loop/lid; other site 315730010149 ABC transporter signature motif; other site 315730010150 Walker B; other site 315730010151 D-loop; other site 315730010152 H-loop/switch region; other site 315730010153 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 315730010154 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 315730010155 ligand binding site [chemical binding]; other site 315730010156 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 315730010157 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730010158 DNA-binding site [nucleotide binding]; DNA binding site 315730010159 UTRA domain; Region: UTRA; cl01230 315730010160 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 315730010161 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730010162 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 315730010163 YlzJ-like protein; Region: YlzJ; pfam14035 315730010164 Clp protease; Region: CLP_protease; pfam00574 315730010165 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 315730010166 active site 315730010167 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 315730010168 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315730010169 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 315730010170 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 315730010171 dihydrodipicolinate synthase; Region: dapA; TIGR00674 315730010172 dimer interface [polypeptide binding]; other site 315730010173 active site 315730010174 catalytic residue [active] 315730010175 aspartate kinase I; Reviewed; Region: PRK08210 315730010176 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 315730010177 nucleotide binding site [chemical binding]; other site 315730010178 substrate binding site [chemical binding]; other site 315730010179 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 315730010180 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 315730010181 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 315730010182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730010183 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 315730010184 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 315730010185 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 315730010186 active site 315730010187 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 315730010188 Holin family; Region: Phage_holin_4; cl01989 315730010189 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 315730010190 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 315730010191 Reovirus sigma C capsid protein; Region: Reo_sigmaC; pfam04582 315730010192 Phage-related protein [Function unknown]; Region: COG4722; cl15832 315730010193 Phage tail protein; Region: Sipho_tail; pfam05709 315730010194 Phage-related minor tail protein [Function unknown]; Region: COG5280 315730010195 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 315730010196 Phage-related protein [Function unknown]; Region: COG5412 315730010197 membrane protein P6; Region: PHA01399 315730010198 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 315730010199 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 315730010200 Phage capsid family; Region: Phage_capsid; pfam05065 315730010201 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 315730010202 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 315730010203 oligomer interface [polypeptide binding]; other site 315730010204 active site residues [active] 315730010205 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 315730010206 Phage-related protein [Function unknown]; Region: COG4695; cl01923 315730010207 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 315730010208 Phage Terminase; Region: Terminase_1; pfam03354 315730010209 Phage terminase, small subunit; Region: Terminase_4; cl01525 315730010210 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 315730010211 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 315730010212 DNA-binding site [nucleotide binding]; DNA binding site 315730010213 RNA-binding motif; other site 315730010214 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 315730010215 Int/Topo IB signature motif; other site 315730010216 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 315730010217 Protein of unknown function (DUF3983); Region: DUF3983; pfam13137 315730010218 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 315730010219 Protein of unknown function (DUF4021); Region: DUF4021; pfam13213 315730010220 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 315730010221 replicative DNA helicase; Provisional; Region: PRK06749 315730010222 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 315730010223 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 315730010224 Walker A motif; other site 315730010225 ATP binding site [chemical binding]; other site 315730010226 Walker B motif; other site 315730010227 DNA binding loops [nucleotide binding] 315730010228 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 315730010229 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730010230 non-specific DNA binding site [nucleotide binding]; other site 315730010231 salt bridge; other site 315730010232 sequence-specific DNA binding site [nucleotide binding]; other site 315730010233 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 315730010234 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730010235 non-specific DNA binding site [nucleotide binding]; other site 315730010236 salt bridge; other site 315730010237 sequence-specific DNA binding site [nucleotide binding]; other site 315730010238 Domain of unknown function (DUF955); Region: DUF955; cl01076 315730010239 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 315730010240 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 315730010241 catalytic residues [active] 315730010242 catalytic nucleophile [active] 315730010243 Recombinase; Region: Recombinase; pfam07508 315730010244 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 315730010245 Flavoprotein; Region: Flavoprotein; cl08021 315730010246 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 315730010247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730010248 NAD(P) binding pocket [chemical binding]; other site 315730010249 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 315730010250 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 315730010251 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 315730010252 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 315730010253 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 315730010254 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 315730010255 NodB motif; other site 315730010256 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 315730010257 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 315730010258 RNase E interface [polypeptide binding]; other site 315730010259 trimer interface [polypeptide binding]; other site 315730010260 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 315730010261 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 315730010262 RNase E interface [polypeptide binding]; other site 315730010263 trimer interface [polypeptide binding]; other site 315730010264 active site 315730010265 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 315730010266 putative nucleic acid binding region [nucleotide binding]; other site 315730010267 G-X-X-G motif; other site 315730010268 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 315730010269 RNA binding site [nucleotide binding]; other site 315730010270 domain interface; other site 315730010271 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 315730010272 16S/18S rRNA binding site [nucleotide binding]; other site 315730010273 S13e-L30e interaction site [polypeptide binding]; other site 315730010274 25S rRNA binding site [nucleotide binding]; other site 315730010275 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 315730010276 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 315730010277 active site 315730010278 Riboflavin kinase; Region: Flavokinase; cl03312 315730010279 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 315730010280 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 315730010281 RNA binding site [nucleotide binding]; other site 315730010282 active site 315730010283 Ribosome-binding factor A; Region: RBFA; cl00542 315730010284 Protein of unknown function (DUF503); Region: DUF503; cl00669 315730010285 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 315730010286 translation initiation factor IF-2; Region: IF-2; TIGR00487 315730010287 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 315730010288 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 315730010289 G1 box; other site 315730010290 putative GEF interaction site [polypeptide binding]; other site 315730010291 GTP/Mg2+ binding site [chemical binding]; other site 315730010292 Switch I region; other site 315730010293 G2 box; other site 315730010294 G3 box; other site 315730010295 Switch II region; other site 315730010296 G4 box; other site 315730010297 G5 box; other site 315730010298 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 315730010299 Translation-initiation factor 2; Region: IF-2; pfam11987 315730010300 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 315730010301 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 315730010302 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 315730010303 putative RNA binding cleft [nucleotide binding]; other site 315730010304 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 315730010305 NusA N-terminal domain; Region: NusA_N; pfam08529 315730010306 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 315730010307 RNA binding site [nucleotide binding]; other site 315730010308 homodimer interface [polypeptide binding]; other site 315730010309 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 315730010310 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 315730010311 G-X-X-G motif; other site 315730010312 ribosome maturation protein RimP; Reviewed; Region: PRK00092 315730010313 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 315730010314 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 315730010315 Sm1 motif; other site 315730010316 predicted subunit interaction site [polypeptide binding]; other site 315730010317 RNA binding pocket [nucleotide binding]; other site 315730010318 Sm2 motif; other site 315730010319 DNA polymerase III PolC; Validated; Region: polC; PRK00448 315730010320 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 315730010321 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 315730010322 generic binding surface II; other site 315730010323 generic binding surface I; other site 315730010324 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 315730010325 active site 315730010326 substrate binding site [chemical binding]; other site 315730010327 catalytic site [active] 315730010328 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 315730010329 prolyl-tRNA synthetase; Provisional; Region: PRK09194 315730010330 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 315730010331 dimer interface [polypeptide binding]; other site 315730010332 motif 1; other site 315730010333 active site 315730010334 motif 2; other site 315730010335 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 315730010336 putative deacylase active site [active] 315730010337 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 315730010338 active site 315730010339 motif 3; other site 315730010340 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 315730010341 anticodon binding site; other site 315730010342 RIP metalloprotease RseP; Region: TIGR00054 315730010343 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 315730010344 active site 315730010345 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 315730010346 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 315730010347 protein binding site [polypeptide binding]; other site 315730010348 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 315730010349 putative substrate binding region [chemical binding]; other site 315730010350 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 315730010351 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 315730010352 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 315730010353 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 315730010354 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 315730010355 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 315730010356 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 315730010357 catalytic residue [active] 315730010358 putative FPP diphosphate binding site; other site 315730010359 putative FPP binding hydrophobic cleft; other site 315730010360 dimer interface [polypeptide binding]; other site 315730010361 putative IPP diphosphate binding site; other site 315730010362 ribosome recycling factor; Reviewed; Region: frr; PRK00083 315730010363 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 315730010364 hinge region; other site 315730010365 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 315730010366 putative nucleotide binding site [chemical binding]; other site 315730010367 uridine monophosphate binding site [chemical binding]; other site 315730010368 homohexameric interface [polypeptide binding]; other site 315730010369 elongation factor Ts; Provisional; Region: tsf; PRK09377 315730010370 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 315730010371 Elongation factor TS; Region: EF_TS; pfam00889 315730010372 Elongation factor TS; Region: EF_TS; pfam00889 315730010373 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 315730010374 rRNA interaction site [nucleotide binding]; other site 315730010375 S8 interaction site; other site 315730010376 putative laminin-1 binding site; other site 315730010377 transcriptional repressor CodY; Validated; Region: PRK04158 315730010378 CodY GAF-like domain; Region: CodY; pfam06018 315730010379 Helix-turn-helix domains; Region: HTH; cl00088 315730010380 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 315730010381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730010382 Walker A motif; other site 315730010383 ATP binding site [chemical binding]; other site 315730010384 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730010385 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 315730010386 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 315730010387 active site 315730010388 HslU subunit interaction site [polypeptide binding]; other site 315730010389 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 315730010390 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 315730010391 Int/Topo IB signature motif; other site 315730010392 active site 315730010393 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 315730010394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730010395 DNA topoisomerase I; Validated; Region: PRK05582 315730010396 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 315730010397 active site 315730010398 interdomain interaction site; other site 315730010399 putative metal-binding site [ion binding]; other site 315730010400 nucleotide binding site [chemical binding]; other site 315730010401 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 315730010402 domain I; other site 315730010403 DNA binding groove [nucleotide binding] 315730010404 phosphate binding site [ion binding]; other site 315730010405 domain II; other site 315730010406 domain III; other site 315730010407 nucleotide binding site [chemical binding]; other site 315730010408 catalytic site [active] 315730010409 domain IV; other site 315730010410 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 315730010411 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 315730010412 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 315730010413 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 315730010414 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 315730010415 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730010416 CoA-ligase; Region: Ligase_CoA; cl02894 315730010417 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 315730010418 ATP-grasp domain; Region: ATP-grasp_4; cl03087 315730010419 CoA-ligase; Region: Ligase_CoA; cl02894 315730010420 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 315730010421 RNA/DNA hybrid binding site [nucleotide binding]; other site 315730010422 active site 315730010423 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 315730010424 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 315730010425 GTP/Mg2+ binding site [chemical binding]; other site 315730010426 G4 box; other site 315730010427 G5 box; other site 315730010428 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730010429 G1 box; other site 315730010430 G1 box; other site 315730010431 GTP/Mg2+ binding site [chemical binding]; other site 315730010432 Switch I region; other site 315730010433 G2 box; other site 315730010434 G2 box; other site 315730010435 G3 box; other site 315730010436 G3 box; other site 315730010437 Switch II region; other site 315730010438 Switch II region; other site 315730010439 G4 box; other site 315730010440 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 315730010441 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 315730010442 Catalytic site [active] 315730010443 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 315730010444 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 315730010445 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 315730010446 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 315730010447 RimM N-terminal domain; Region: RimM; pfam01782 315730010448 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 315730010449 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 315730010450 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 315730010451 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 315730010452 signal recognition particle protein; Provisional; Region: PRK10867 315730010453 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 315730010454 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 315730010455 P loop; other site 315730010456 GTP binding site [chemical binding]; other site 315730010457 Signal peptide binding domain; Region: SRP_SPB; pfam02978 315730010458 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 315730010459 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 315730010460 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 315730010461 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 315730010462 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 315730010463 P loop; other site 315730010464 GTP binding site [chemical binding]; other site 315730010465 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 315730010466 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 315730010467 Walker A/P-loop; other site 315730010468 ATP binding site [chemical binding]; other site 315730010469 Q-loop/lid; other site 315730010470 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 315730010471 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 315730010472 ABC transporter signature motif; other site 315730010473 Walker B; other site 315730010474 D-loop; other site 315730010475 H-loop/switch region; other site 315730010476 ribonuclease III; Reviewed; Region: rnc; PRK00102 315730010477 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 315730010478 dimerization interface [polypeptide binding]; other site 315730010479 active site 315730010480 metal binding site [ion binding]; metal-binding site 315730010481 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 315730010482 dsRNA binding site [nucleotide binding]; other site 315730010483 Phosphopantetheine attachment site; Region: PP-binding; cl09936 315730010484 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 315730010485 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 315730010486 NAD(P) binding site [chemical binding]; other site 315730010487 homotetramer interface [polypeptide binding]; other site 315730010488 homodimer interface [polypeptide binding]; other site 315730010489 active site 315730010490 Acyl transferase domain; Region: Acyl_transf_1; cl08282 315730010491 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 315730010492 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 315730010493 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 315730010494 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 315730010495 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 315730010496 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 315730010497 generic binding surface II; other site 315730010498 ssDNA binding site; other site 315730010499 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315730010500 ATP binding site [chemical binding]; other site 315730010501 putative Mg++ binding site [ion binding]; other site 315730010502 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315730010503 nucleotide binding region [chemical binding]; other site 315730010504 ATP-binding site [chemical binding]; other site 315730010505 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 315730010506 DAK2 domain; Region: Dak2; cl03685 315730010507 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 315730010508 Asp23 family; Region: Asp23; cl00574 315730010509 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 315730010510 Thiamine pyrophosphokinase; Region: TPK; cd07995 315730010511 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 315730010512 active site 315730010513 dimerization interface [polypeptide binding]; other site 315730010514 thiamine binding site [chemical binding]; other site 315730010515 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 315730010516 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 315730010517 substrate binding site [chemical binding]; other site 315730010518 hexamer interface [polypeptide binding]; other site 315730010519 metal binding site [ion binding]; metal-binding site 315730010520 GTPase RsgA; Reviewed; Region: PRK00098 315730010521 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 315730010522 RNA binding site [nucleotide binding]; other site 315730010523 homodimer interface [polypeptide binding]; other site 315730010524 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 315730010525 GTPase/Zn-binding domain interface [polypeptide binding]; other site 315730010526 GTP/Mg2+ binding site [chemical binding]; other site 315730010527 G4 box; other site 315730010528 G5 box; other site 315730010529 G1 box; other site 315730010530 Switch I region; other site 315730010531 G2 box; other site 315730010532 G3 box; other site 315730010533 Switch II region; other site 315730010534 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 315730010535 Catalytic domain of Protein Kinases; Region: PKc; cd00180 315730010536 active site 315730010537 ATP binding site [chemical binding]; other site 315730010538 substrate binding site [chemical binding]; other site 315730010539 activation loop (A-loop); other site 315730010540 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 315730010541 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 315730010542 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 315730010543 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 315730010544 Protein phosphatase 2C; Region: PP2C; pfam00481 315730010545 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 315730010546 active site 315730010547 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 315730010548 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315730010549 FeS/SAM binding site; other site 315730010550 16S rRNA methyltransferase B; Provisional; Region: PRK14902 315730010551 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 315730010552 putative RNA binding site [nucleotide binding]; other site 315730010553 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730010554 S-adenosylmethionine binding site [chemical binding]; other site 315730010555 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 315730010556 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 315730010557 putative active site [active] 315730010558 substrate binding site [chemical binding]; other site 315730010559 putative cosubstrate binding site; other site 315730010560 catalytic site [active] 315730010561 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 315730010562 substrate binding site [chemical binding]; other site 315730010563 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 315730010564 active site 315730010565 catalytic residues [active] 315730010566 metal binding site [ion binding]; metal-binding site 315730010567 primosome assembly protein PriA; Validated; Region: PRK05580 315730010568 primosome assembly protein PriA; Validated; Region: PRK05580 315730010569 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315730010570 ATP binding site [chemical binding]; other site 315730010571 putative Mg++ binding site [ion binding]; other site 315730010572 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730010573 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 315730010574 Flavoprotein; Region: Flavoprotein; cl08021 315730010575 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 315730010576 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 315730010577 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 315730010578 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 315730010579 catalytic site [active] 315730010580 G-X2-G-X-G-K; other site 315730010581 Domain of unknown function (DUF370); Region: DUF370; cl00898 315730010582 hypothetical protein; Provisional; Region: PRK11820 315730010583 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 315730010584 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 315730010585 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 315730010586 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 315730010587 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 315730010588 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 315730010589 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730010590 motif II; other site 315730010591 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 315730010592 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 315730010593 Domain of unknown function (DUF814); Region: DUF814; pfam05670 315730010594 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 315730010595 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 315730010596 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 315730010597 active site 315730010598 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 315730010599 DinB superfamily; Region: DinB_2; pfam12867 315730010600 YoqO-like protein; Region: YoqO; pfam14037 315730010601 YoqO-like protein; Region: YoqO; pfam14037 315730010602 Proteins of 100 residues with WXG; Region: WXG100; cl02005 315730010603 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 315730010604 Uncharacterized protein conserved in bacteria (DUF2247); Region: DUF2247; cl01763 315730010605 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 315730010606 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 315730010607 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315730010608 active site 315730010609 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 315730010610 active site 315730010611 dimer interface [polypeptide binding]; other site 315730010612 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 315730010613 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 315730010614 heterodimer interface [polypeptide binding]; other site 315730010615 active site 315730010616 FMN binding site [chemical binding]; other site 315730010617 homodimer interface [polypeptide binding]; other site 315730010618 substrate binding site [chemical binding]; other site 315730010619 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 315730010620 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 315730010621 FAD binding pocket [chemical binding]; other site 315730010622 FAD binding motif [chemical binding]; other site 315730010623 phosphate binding motif [ion binding]; other site 315730010624 beta-alpha-beta structure motif; other site 315730010625 NAD binding pocket [chemical binding]; other site 315730010626 Iron coordination center [ion binding]; other site 315730010627 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 315730010628 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 315730010629 ATP-grasp domain; Region: ATP-grasp_4; cl03087 315730010630 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 315730010631 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 315730010632 ATP-grasp domain; Region: ATP-grasp_4; cl03087 315730010633 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 315730010634 IMP binding site; other site 315730010635 dimer interface [polypeptide binding]; other site 315730010636 interdomain contacts; other site 315730010637 partial ornithine binding site; other site 315730010638 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 315730010639 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 315730010640 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 315730010641 catalytic site [active] 315730010642 subunit interface [polypeptide binding]; other site 315730010643 dihydroorotase; Validated; Region: pyrC; PRK09357 315730010644 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 315730010645 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 315730010646 active site 315730010647 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 315730010648 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 315730010649 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730010650 uracil transporter; Provisional; Region: PRK10720 315730010651 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 315730010652 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315730010653 active site 315730010654 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 315730010655 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315730010656 RNA binding surface [nucleotide binding]; other site 315730010657 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 315730010658 active site 315730010659 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 315730010660 lipoprotein signal peptidase; Provisional; Region: PRK14787 315730010661 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 315730010662 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 315730010663 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 315730010664 active site 315730010665 HIGH motif; other site 315730010666 nucleotide binding site [chemical binding]; other site 315730010667 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 315730010668 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 315730010669 active site 315730010670 KMSKS motif; other site 315730010671 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 315730010672 tRNA binding surface [nucleotide binding]; other site 315730010673 anticodon binding site; other site 315730010674 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 315730010675 DivIVA protein; Region: DivIVA; pfam05103 315730010676 DivIVA domain; Region: DivI1A_domain; TIGR03544 315730010677 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 315730010678 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315730010679 RNA binding surface [nucleotide binding]; other site 315730010680 YGGT family; Region: YGGT; cl00508 315730010681 Protein of unknown function (DUF552); Region: DUF552; cl00775 315730010682 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 315730010683 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 315730010684 catalytic residue [active] 315730010685 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 315730010686 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 315730010687 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 315730010688 sporulation sigma factor SigG; Reviewed; Region: PRK08215 315730010689 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730010690 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 315730010691 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730010692 DNA binding residues [nucleotide binding] 315730010693 sporulation sigma factor SigE; Reviewed; Region: PRK08301 315730010694 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730010695 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730010696 DNA binding residues [nucleotide binding] 315730010697 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 315730010698 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 315730010699 cell division protein FtsZ; Validated; Region: PRK09330 315730010700 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 315730010701 nucleotide binding site [chemical binding]; other site 315730010702 SulA interaction site; other site 315730010703 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 315730010704 Cell division protein FtsA; Region: FtsA; cl11496 315730010705 Cell division protein FtsA; Region: FtsA; cl11496 315730010706 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 315730010707 Cell division protein FtsQ; Region: FtsQ; pfam03799 315730010708 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 315730010709 FAD binding domain; Region: FAD_binding_4; pfam01565 315730010710 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 315730010711 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 315730010712 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 315730010713 active site 315730010714 homodimer interface [polypeptide binding]; other site 315730010715 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 315730010716 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 315730010717 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730010718 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 315730010719 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 315730010720 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 315730010721 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 315730010722 Mg++ binding site [ion binding]; other site 315730010723 putative catalytic motif [active] 315730010724 putative substrate binding site [chemical binding]; other site 315730010725 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 315730010726 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 315730010727 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 315730010728 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 315730010729 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 315730010730 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315730010731 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730010732 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 315730010733 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 315730010734 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315730010735 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730010736 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 315730010737 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 315730010738 Septum formation initiator; Region: DivIC; cl11433 315730010739 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 315730010740 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730010741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 315730010742 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 315730010743 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 315730010744 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730010745 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 315730010746 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730010747 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 315730010748 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 315730010749 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 315730010750 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 315730010751 hypothetical protein; Provisional; Region: PRK13670 315730010752 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 315730010753 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 315730010754 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 315730010755 protein binding site [polypeptide binding]; other site 315730010756 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 315730010757 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 315730010758 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 315730010759 active site 315730010760 nucleophile elbow; other site 315730010761 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 315730010762 Nucleoside recognition; Region: Gate; cl00486 315730010763 Nucleoside recognition; Region: Gate; cl00486 315730010764 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 315730010765 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 315730010766 active site 315730010767 (T/H)XGH motif; other site 315730010768 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730010769 S-adenosylmethionine binding site [chemical binding]; other site 315730010770 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 315730010771 Protein of unknown function (DUF964); Region: DUF964; cl01483 315730010772 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 315730010773 catalytic core [active] 315730010774 YlbE-like protein; Region: YlbE; pfam14003 315730010775 Putative coat protein; Region: YlbD_coat; pfam14071 315730010776 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 315730010777 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 315730010778 YugN-like family; Region: YugN; pfam08868 315730010779 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 315730010780 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 315730010781 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 315730010782 Subunit I/III interface [polypeptide binding]; other site 315730010783 Subunit III/IV interface [polypeptide binding]; other site 315730010784 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 315730010785 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 315730010786 D-pathway; other site 315730010787 Putative ubiquinol binding site [chemical binding]; other site 315730010788 Low-spin heme (heme b) binding site [chemical binding]; other site 315730010789 Putative water exit pathway; other site 315730010790 Binuclear center (heme o3/CuB) [ion binding]; other site 315730010791 K-pathway; other site 315730010792 Putative proton exit pathway; other site 315730010793 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 315730010794 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 315730010795 Cytochrome c; Region: Cytochrom_C; cl11414 315730010796 UbiA prenyltransferase family; Region: UbiA; cl00337 315730010797 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 315730010798 pyruvate carboxylase; Reviewed; Region: PRK12999 315730010799 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 315730010800 ATP-grasp domain; Region: ATP-grasp_4; cl03087 315730010801 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 315730010802 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 315730010803 active site 315730010804 catalytic residues [active] 315730010805 metal binding site [ion binding]; metal-binding site 315730010806 homodimer binding site [polypeptide binding]; other site 315730010807 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 315730010808 carboxyltransferase (CT) interaction site; other site 315730010809 biotinylation site [posttranslational modification]; other site 315730010810 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 315730010811 Protein of unknown function (DUF1507); Region: DUF1507; cl11487 315730010812 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 315730010813 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 315730010814 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 315730010815 putative active site [active] 315730010816 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730010817 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 315730010818 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; cl11558 315730010819 YlaH-like protein; Region: YlaH; pfam14036 315730010820 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 315730010821 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 315730010822 G1 box; other site 315730010823 putative GEF interaction site [polypeptide binding]; other site 315730010824 GTP/Mg2+ binding site [chemical binding]; other site 315730010825 Switch I region; other site 315730010826 G2 box; other site 315730010827 G3 box; other site 315730010828 Switch II region; other site 315730010829 G4 box; other site 315730010830 G5 box; other site 315730010831 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 315730010832 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 315730010833 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 315730010834 active site 315730010835 Protein of unknown function (DUF1054); Region: DUF1054; cl11544 315730010836 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 315730010837 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 315730010838 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 315730010839 homodimer interface [polypeptide binding]; other site 315730010840 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730010841 catalytic residue [active] 315730010842 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 315730010843 transglutaminase; Provisional; Region: tgl; PRK03187 315730010844 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 315730010845 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 315730010846 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 315730010847 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 315730010848 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 315730010849 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 315730010850 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315730010851 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 315730010852 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 315730010853 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 315730010854 E3 interaction surface; other site 315730010855 lipoyl attachment site [posttranslational modification]; other site 315730010856 e3 binding domain; Region: E3_binding; pfam02817 315730010857 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 315730010858 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 315730010859 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 315730010860 alpha subunit interface [polypeptide binding]; other site 315730010861 TPP binding site [chemical binding]; other site 315730010862 heterodimer interface [polypeptide binding]; other site 315730010863 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 315730010864 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 315730010865 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 315730010866 active site 315730010867 catalytic residues [active] 315730010868 metal binding site [ion binding]; metal-binding site 315730010869 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730010870 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 315730010871 active site 315730010872 motif I; other site 315730010873 motif II; other site 315730010874 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 315730010875 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 315730010876 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 315730010877 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315730010878 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 315730010879 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 315730010880 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730010881 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 315730010882 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 315730010883 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 315730010884 metal binding site [ion binding]; metal-binding site 315730010885 putative dimer interface [polypeptide binding]; other site 315730010886 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 315730010887 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 315730010888 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 315730010889 trimer interface [polypeptide binding]; other site 315730010890 active site 315730010891 substrate binding site [chemical binding]; other site 315730010892 CoA binding site [chemical binding]; other site 315730010893 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315730010894 Helix-turn-helix domains; Region: HTH; cl00088 315730010895 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 315730010896 dimerization interface [polypeptide binding]; other site 315730010897 FOG: CBS domain [General function prediction only]; Region: COG0517 315730010898 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 315730010899 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 315730010900 Protein of unknown function (DUF458); Region: DUF458; cl00861 315730010901 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 315730010902 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 315730010903 catalytic residues [active] 315730010904 Protein of unknown function (DUF3993); Region: DUF3993; pfam13158 315730010905 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 315730010906 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 315730010907 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 315730010908 short chain dehydrogenase; Provisional; Region: PRK07677 315730010909 NAD(P) binding site [chemical binding]; other site 315730010910 substrate binding site [chemical binding]; other site 315730010911 homotetramer interface [polypeptide binding]; other site 315730010912 active site 315730010913 homodimer interface [polypeptide binding]; other site 315730010914 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 315730010915 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 315730010916 putative active site [active] 315730010917 putative metal binding site [ion binding]; other site 315730010918 polyphosphate kinase; Provisional; Region: PRK05443 315730010919 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 315730010920 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 315730010921 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 315730010922 putative domain interface [polypeptide binding]; other site 315730010923 putative active site [active] 315730010924 catalytic site [active] 315730010925 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 315730010926 putative domain interface [polypeptide binding]; other site 315730010927 putative active site [active] 315730010928 catalytic site [active] 315730010929 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 315730010930 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 315730010931 YkyB-like protein; Region: YkyB; pfam14177 315730010932 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 315730010933 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 315730010934 active site 315730010935 I-site; other site 315730010936 metal binding site [ion binding]; metal-binding site 315730010937 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730010938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730010939 putative substrate translocation pore; other site 315730010940 Helix-turn-helix domains; Region: HTH; cl00088 315730010941 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 315730010942 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 315730010943 THF binding site; other site 315730010944 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 315730010945 substrate binding site [chemical binding]; other site 315730010946 THF binding site; other site 315730010947 zinc-binding site [ion binding]; other site 315730010948 Competence protein J (ComJ); Region: ComJ; pfam11033 315730010949 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 315730010950 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 315730010951 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730010952 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730010953 dimer interface [polypeptide binding]; other site 315730010954 phosphorylation site [posttranslational modification] 315730010955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730010956 ATP binding site [chemical binding]; other site 315730010957 Mg2+ binding site [ion binding]; other site 315730010958 G-X-G motif; other site 315730010959 aminotransferase A; Validated; Region: PRK07683 315730010960 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315730010961 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730010962 homodimer interface [polypeptide binding]; other site 315730010963 catalytic residue [active] 315730010964 Transcriptional regulators [Transcription]; Region: PurR; COG1609 315730010965 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315730010966 DNA binding site [nucleotide binding] 315730010967 domain linker motif; other site 315730010968 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 315730010969 putative dimerization interface [polypeptide binding]; other site 315730010970 putative ligand binding site [chemical binding]; other site 315730010971 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 315730010972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730010973 dimer interface [polypeptide binding]; other site 315730010974 conserved gate region; other site 315730010975 putative PBP binding loops; other site 315730010976 ABC-ATPase subunit interface; other site 315730010977 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730010978 dimer interface [polypeptide binding]; other site 315730010979 conserved gate region; other site 315730010980 putative PBP binding loops; other site 315730010981 ABC-ATPase subunit interface; other site 315730010982 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 315730010983 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 315730010984 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 315730010985 homodimer interface [polypeptide binding]; other site 315730010986 maltodextrin glucosidase; Provisional; Region: PRK10785 315730010987 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 315730010988 active site 315730010989 homodimer interface [polypeptide binding]; other site 315730010990 catalytic site [active] 315730010991 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 315730010992 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 315730010993 Ca binding site [ion binding]; other site 315730010994 active site 315730010995 catalytic site [active] 315730010996 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 315730010997 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 315730010998 Walker A/P-loop; other site 315730010999 ATP binding site [chemical binding]; other site 315730011000 Q-loop/lid; other site 315730011001 ABC transporter signature motif; other site 315730011002 Walker B; other site 315730011003 D-loop; other site 315730011004 H-loop/switch region; other site 315730011005 TOBE domain; Region: TOBE_2; cl01440 315730011006 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730011007 NAD(P) binding site [chemical binding]; other site 315730011008 RDD family; Region: RDD; cl00746 315730011009 Protein of unknown function (DUF3997); Region: DUF3997; pfam13162 315730011010 Predicted ATPase [General function prediction only]; Region: COG3910 315730011011 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730011012 Walker A/P-loop; other site 315730011013 ATP binding site [chemical binding]; other site 315730011014 Q-loop/lid; other site 315730011015 ABC transporter signature motif; other site 315730011016 Walker B; other site 315730011017 D-loop; other site 315730011018 H-loop/switch region; other site 315730011019 putative acyltransferase; Provisional; Region: PRK05790 315730011020 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 315730011021 dimer interface [polypeptide binding]; other site 315730011022 active site 315730011023 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 315730011024 nudix motif; other site 315730011025 Protein of unknown function (DUF3928); Region: DUF3928; pfam13065 315730011026 hypothetical protein; Validated; Region: PRK07668 315730011027 hypothetical protein; Validated; Region: PRK07668 315730011028 Helix-turn-helix domains; Region: HTH; cl00088 315730011029 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730011030 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 315730011031 NAD(P) binding site [chemical binding]; other site 315730011032 active site 315730011033 YvrJ protein family; Region: YvrJ; pfam12841 315730011034 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 315730011035 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 315730011036 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315730011037 Predicted amidohydrolase [General function prediction only]; Region: COG0388 315730011038 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 315730011039 putative active site [active] 315730011040 catalytic triad [active] 315730011041 putative dimer interface [polypeptide binding]; other site 315730011042 transaminase; Reviewed; Region: PRK08068 315730011043 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315730011044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730011045 homodimer interface [polypeptide binding]; other site 315730011046 catalytic residue [active] 315730011047 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 315730011048 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 315730011049 dimer interface [polypeptide binding]; other site 315730011050 active site 315730011051 catalytic residue [active] 315730011052 metal binding site [ion binding]; metal-binding site 315730011053 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 315730011054 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 315730011055 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 315730011056 intersubunit interface [polypeptide binding]; other site 315730011057 active site 315730011058 Zn2+ binding site [ion binding]; other site 315730011059 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 315730011060 Cupin domain; Region: Cupin_2; cl09118 315730011061 Protein of unknown function (DUF3909); Region: DUF3909; pfam13077 315730011062 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 315730011063 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730011064 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 315730011065 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730011066 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 315730011067 metal binding site [ion binding]; metal-binding site 315730011068 active site 315730011069 I-site; other site 315730011070 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 315730011071 dimer interface [polypeptide binding]; other site 315730011072 FMN binding site [chemical binding]; other site 315730011073 Protein of unknown function (DUF3915); Region: DUF3915; pfam13054 315730011074 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 315730011075 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 315730011076 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 315730011077 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 315730011078 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 315730011079 dimerization domain swap beta strand [polypeptide binding]; other site 315730011080 regulatory protein interface [polypeptide binding]; other site 315730011081 active site 315730011082 regulatory phosphorylation site [posttranslational modification]; other site 315730011083 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 315730011084 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 315730011085 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 315730011086 active site turn [active] 315730011087 phosphorylation site [posttranslational modification] 315730011088 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 315730011089 HPr interaction site; other site 315730011090 glycerol kinase (GK) interaction site [polypeptide binding]; other site 315730011091 active site 315730011092 phosphorylation site [posttranslational modification] 315730011093 transcriptional antiterminator BglG; Provisional; Region: PRK09772 315730011094 CAT RNA binding domain; Region: CAT_RBD; cl03904 315730011095 PRD domain; Region: PRD; cl15445 315730011096 PRD domain; Region: PRD; cl15445 315730011097 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 315730011098 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730011099 active site 315730011100 motif I; other site 315730011101 motif II; other site 315730011102 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730011103 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 315730011104 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730011105 DNA-binding site [nucleotide binding]; DNA binding site 315730011106 UTRA domain; Region: UTRA; cl01230 315730011107 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 315730011108 active site 315730011109 trimer interface [polypeptide binding]; other site 315730011110 allosteric site; other site 315730011111 active site lid [active] 315730011112 hexamer (dimer of trimers) interface [polypeptide binding]; other site 315730011113 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 315730011114 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 315730011115 active site 315730011116 dimer interface [polypeptide binding]; other site 315730011117 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315730011118 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 315730011119 ScpA/B protein; Region: ScpA_ScpB; cl00598 315730011120 Domain of unknown function (DUF309); Region: DUF309; cl00667 315730011121 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730011122 Coenzyme A binding pocket [chemical binding]; other site 315730011123 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 315730011124 active site 315730011125 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 315730011126 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 315730011127 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 315730011128 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 315730011129 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 315730011130 SpoVA protein; Region: SpoVA; cl04298 315730011131 stage V sporulation protein AD; Validated; Region: PRK08304 315730011132 stage V sporulation protein AD; Provisional; Region: PRK12404 315730011133 SpoVA protein; Region: SpoVA; cl04298 315730011134 Cortical protein marker for cell polarity; Region: Rax2; pfam12768 315730011135 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 315730011136 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 315730011137 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 315730011138 sporulation sigma factor SigF; Validated; Region: PRK05572 315730011139 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730011140 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 315730011141 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730011142 DNA binding residues [nucleotide binding] 315730011143 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 315730011144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730011145 ATP binding site [chemical binding]; other site 315730011146 Mg2+ binding site [ion binding]; other site 315730011147 G-X-G motif; other site 315730011148 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 315730011149 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 315730011150 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730011151 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 315730011152 Predicted transcriptional regulators [Transcription]; Region: COG1725 315730011153 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730011154 DNA-binding site [nucleotide binding]; DNA binding site 315730011155 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315730011156 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 315730011157 Walker A/P-loop; other site 315730011158 ATP binding site [chemical binding]; other site 315730011159 Q-loop/lid; other site 315730011160 ABC transporter signature motif; other site 315730011161 Walker B; other site 315730011162 D-loop; other site 315730011163 H-loop/switch region; other site 315730011164 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 315730011165 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315730011166 Helix-turn-helix domains; Region: HTH; cl00088 315730011167 Helix-turn-helix domains; Region: HTH; cl00088 315730011168 Protein of unknown function (DUF541); Region: SIMPL; cl01077 315730011169 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 315730011170 magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383 315730011171 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 315730011172 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 315730011173 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 315730011174 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 315730011175 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 315730011176 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 315730011177 Sulfatase; Region: Sulfatase; cl10460 315730011178 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 315730011179 FixH; Region: FixH; cl01254 315730011180 FixH; Region: FixH; cl01254 315730011181 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 315730011182 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 315730011183 Int/Topo IB signature motif; other site 315730011184 active site 315730011185 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 315730011186 ferric uptake regulator; Provisional; Region: fur; PRK09462 315730011187 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 315730011188 metal binding site 2 [ion binding]; metal-binding site 315730011189 putative DNA binding helix; other site 315730011190 metal binding site 1 [ion binding]; metal-binding site 315730011191 dimer interface [polypeptide binding]; other site 315730011192 structural Zn2+ binding site [ion binding]; other site 315730011193 Integral membrane protein DUF95; Region: DUF95; cl00572 315730011194 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730011195 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730011196 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 315730011197 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 315730011198 dimer interface [polypeptide binding]; other site 315730011199 ADP-ribose binding site [chemical binding]; other site 315730011200 active site 315730011201 nudix motif; other site 315730011202 metal binding site [ion binding]; metal-binding site 315730011203 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 315730011204 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 315730011205 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 315730011206 active site 315730011207 catalytic tetrad [active] 315730011208 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 315730011209 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 315730011210 active site 315730011211 catalytic tetrad [active] 315730011212 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 315730011213 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 315730011214 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 315730011215 putative active site [active] 315730011216 putative metal binding site [ion binding]; other site 315730011217 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 315730011218 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 315730011219 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730011220 Predicted permease [General function prediction only]; Region: COG2056 315730011221 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 315730011222 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 315730011223 Transcriptional regulators [Transcription]; Region: PurR; COG1609 315730011224 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315730011225 DNA binding site [nucleotide binding] 315730011226 domain linker motif; other site 315730011227 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 315730011228 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 315730011229 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730011230 Coenzyme A binding pocket [chemical binding]; other site 315730011231 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 315730011232 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 315730011233 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 315730011234 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 315730011235 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 315730011236 catalytic motif [active] 315730011237 Zn binding site [ion binding]; other site 315730011238 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 315730011239 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 315730011240 Lumazine binding domain; Region: Lum_binding; pfam00677 315730011241 Lumazine binding domain; Region: Lum_binding; pfam00677 315730011242 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 315730011243 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 315730011244 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 315730011245 dimerization interface [polypeptide binding]; other site 315730011246 active site 315730011247 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 315730011248 homopentamer interface [polypeptide binding]; other site 315730011249 active site 315730011250 biotin synthase; Validated; Region: PRK06256 315730011251 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315730011252 FeS/SAM binding site; other site 315730011253 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 315730011254 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 315730011255 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730011256 S-adenosylmethionine binding site [chemical binding]; other site 315730011257 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730011258 Protein of unknown function (DUF452); Region: DUF452; cl01062 315730011259 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315730011260 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 315730011261 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 315730011262 substrate-cofactor binding pocket; other site 315730011263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730011264 catalytic residue [active] 315730011265 AAA domain; Region: AAA_26; pfam13500 315730011266 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730011267 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 315730011268 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 315730011269 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315730011270 inhibitor-cofactor binding pocket; inhibition site 315730011271 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730011272 catalytic residue [active] 315730011273 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 315730011274 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09418 315730011275 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 315730011276 active site 315730011277 metal binding site [ion binding]; metal-binding site 315730011278 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 315730011279 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 315730011280 active site 315730011281 catalytic triad [active] 315730011282 oxyanion hole [active] 315730011283 Helix-turn-helix domains; Region: HTH; cl00088 315730011284 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 315730011285 Proteins of 100 residues with WXG; Region: WXG100; cl02005 315730011286 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 315730011287 ornithine carbamoyltransferase; Provisional; Region: PRK00779 315730011288 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 315730011289 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730011290 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 315730011291 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315730011292 inhibitor-cofactor binding pocket; inhibition site 315730011293 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730011294 catalytic residue [active] 315730011295 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 315730011296 nucleotide binding site [chemical binding]; other site 315730011297 N-acetyl-L-glutamate binding site [chemical binding]; other site 315730011298 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 315730011299 heterotetramer interface [polypeptide binding]; other site 315730011300 active site pocket [active] 315730011301 cleavage site 315730011302 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 315730011303 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730011304 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 315730011305 YqzH-like protein; Region: YqzH; pfam14164 315730011306 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 315730011307 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730011308 NAD(P) binding site [chemical binding]; other site 315730011309 active site 315730011310 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315730011311 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730011312 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 315730011313 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 315730011314 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 315730011315 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 315730011316 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 315730011317 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 315730011318 putative L-serine binding site [chemical binding]; other site 315730011319 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315730011320 Protein of unknown function (DUF3932); Region: DUF3932; pfam13068 315730011321 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 315730011322 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730011323 Walker A/P-loop; other site 315730011324 ATP binding site [chemical binding]; other site 315730011325 Q-loop/lid; other site 315730011326 ABC transporter signature motif; other site 315730011327 Walker B; other site 315730011328 D-loop; other site 315730011329 H-loop/switch region; other site 315730011330 magnesium-transporting ATPase; Provisional; Region: PRK15122 315730011331 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 315730011332 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 315730011333 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 315730011334 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 315730011335 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 315730011336 MgtC family; Region: MgtC; pfam02308 315730011337 DNA polymerase IV; Validated; Region: PRK01810 315730011338 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 315730011339 active site 315730011340 DNA binding site [nucleotide binding] 315730011341 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 315730011342 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 315730011343 peptidase T-like protein; Region: PepT-like; TIGR01883 315730011344 metal binding site [ion binding]; metal-binding site 315730011345 putative dimer interface [polypeptide binding]; other site 315730011346 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 315730011347 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730011348 Protein of unknown function (DUF3894); Region: DUF3894; pfam13033 315730011349 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 315730011350 Predicted membrane protein [Function unknown]; Region: COG4129 315730011351 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 315730011352 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 315730011353 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 315730011354 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 315730011355 Probable transposase; Region: OrfB_IS605; pfam01385 315730011356 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 315730011357 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 315730011358 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 315730011359 Walker A/P-loop; other site 315730011360 ATP binding site [chemical binding]; other site 315730011361 Q-loop/lid; other site 315730011362 ABC transporter signature motif; other site 315730011363 Walker B; other site 315730011364 D-loop; other site 315730011365 H-loop/switch region; other site 315730011366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730011367 dimer interface [polypeptide binding]; other site 315730011368 conserved gate region; other site 315730011369 putative PBP binding loops; other site 315730011370 ABC-ATPase subunit interface; other site 315730011371 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 315730011372 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 315730011373 substrate binding pocket [chemical binding]; other site 315730011374 membrane-bound complex binding site; other site 315730011375 hinge residues; other site 315730011376 Disulphide isomerase; Region: Disulph_isomer; pfam06491 315730011377 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 315730011378 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 315730011379 nudix motif; other site 315730011380 Protein of unknown function (DUF421); Region: DUF421; cl00990 315730011381 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 315730011382 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 315730011383 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 315730011384 E3 interaction surface; other site 315730011385 lipoyl attachment site [posttranslational modification]; other site 315730011386 e3 binding domain; Region: E3_binding; pfam02817 315730011387 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 315730011388 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 315730011389 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 315730011390 alpha subunit interface [polypeptide binding]; other site 315730011391 TPP binding site [chemical binding]; other site 315730011392 heterodimer interface [polypeptide binding]; other site 315730011393 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 315730011394 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 315730011395 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 315730011396 tetramer interface [polypeptide binding]; other site 315730011397 TPP-binding site [chemical binding]; other site 315730011398 heterodimer interface [polypeptide binding]; other site 315730011399 phosphorylation loop region [posttranslational modification] 315730011400 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 315730011401 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730011402 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315730011403 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 315730011404 Acetokinase family; Region: Acetate_kinase; cl01029 315730011405 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 315730011406 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 315730011407 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 315730011408 NAD binding site [chemical binding]; other site 315730011409 Phe binding site; other site 315730011410 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 315730011411 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 315730011412 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730011413 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 315730011414 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315730011415 putative active site [active] 315730011416 heme pocket [chemical binding]; other site 315730011417 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 315730011418 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730011419 Walker A motif; other site 315730011420 ATP binding site [chemical binding]; other site 315730011421 Walker B motif; other site 315730011422 arginine finger; other site 315730011423 Helix-turn-helix domains; Region: HTH; cl00088 315730011424 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 315730011425 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 315730011426 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 315730011427 active site 315730011428 catalytic site [active] 315730011429 metal binding site [ion binding]; metal-binding site 315730011430 dimer interface [polypeptide binding]; other site 315730011431 YycC-like protein; Region: YycC; pfam14174 315730011432 hypothetical protein; Provisional; Region: PRK06770 315730011433 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 315730011434 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 315730011435 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 315730011436 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 315730011437 Proteins of 100 residues with WXG; Region: WXG100; cl02005 315730011438 Uncharacterized conserved protein [Function unknown]; Region: COG5444 315730011439 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 315730011440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730011441 active site 315730011442 phosphorylation site [posttranslational modification] 315730011443 intermolecular recognition site; other site 315730011444 dimerization interface [polypeptide binding]; other site 315730011445 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 315730011446 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 315730011447 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 315730011448 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 315730011449 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 315730011450 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 315730011451 Walker A/P-loop; other site 315730011452 ATP binding site [chemical binding]; other site 315730011453 Q-loop/lid; other site 315730011454 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 315730011455 ABC transporter signature motif; other site 315730011456 Walker B; other site 315730011457 D-loop; other site 315730011458 H-loop/switch region; other site 315730011459 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 315730011460 arginine repressor; Provisional; Region: PRK04280 315730011461 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 315730011462 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 315730011463 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315730011464 RNA binding surface [nucleotide binding]; other site 315730011465 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 315730011466 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 315730011467 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 315730011468 TPP-binding site; other site 315730011469 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 315730011470 PYR/PP interface [polypeptide binding]; other site 315730011471 dimer interface [polypeptide binding]; other site 315730011472 TPP binding site [chemical binding]; other site 315730011473 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 315730011474 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 315730011475 substrate binding pocket [chemical binding]; other site 315730011476 chain length determination region; other site 315730011477 substrate-Mg2+ binding site; other site 315730011478 catalytic residues [active] 315730011479 aspartate-rich region 1; other site 315730011480 active site lid residues [active] 315730011481 aspartate-rich region 2; other site 315730011482 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 315730011483 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 315730011484 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 315730011485 generic binding surface II; other site 315730011486 generic binding surface I; other site 315730011487 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 315730011488 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 315730011489 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 315730011490 homodimer interface [polypeptide binding]; other site 315730011491 NADP binding site [chemical binding]; other site 315730011492 substrate binding site [chemical binding]; other site 315730011493 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 315730011494 putative RNA binding site [nucleotide binding]; other site 315730011495 Asp23 family; Region: Asp23; cl00574 315730011496 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 315730011497 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 315730011498 ATP-grasp domain; Region: ATP-grasp_4; cl03087 315730011499 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 315730011500 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 315730011501 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 315730011502 carboxyltransferase (CT) interaction site; other site 315730011503 biotinylation site [posttranslational modification]; other site 315730011504 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 315730011505 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 315730011506 stage III sporulation protein AF; Region: spore_III_AF; TIGR02896 315730011507 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 315730011508 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 315730011509 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 315730011510 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 315730011511 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 315730011512 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 315730011513 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730011514 Walker A motif; other site 315730011515 ATP binding site [chemical binding]; other site 315730011516 Walker B motif; other site 315730011517 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 315730011518 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730011519 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730011520 elongation factor P; Validated; Region: PRK00529 315730011521 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 315730011522 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 315730011523 RNA binding site [nucleotide binding]; other site 315730011524 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 315730011525 RNA binding site [nucleotide binding]; other site 315730011526 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 315730011527 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 315730011528 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 315730011529 active site 315730011530 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 315730011531 trimer interface [polypeptide binding]; other site 315730011532 active site 315730011533 dimer interface [polypeptide binding]; other site 315730011534 Conserved membrane protein YqhR; Region: YqhR; pfam11085 315730011535 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 315730011536 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 315730011537 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 315730011538 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 315730011539 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730011540 motif II; other site 315730011541 manganese transport transcriptional regulator; Provisional; Region: PRK03902 315730011542 Helix-turn-helix domains; Region: HTH; cl00088 315730011543 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 315730011544 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 315730011545 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315730011546 FeS/SAM binding site; other site 315730011547 Helix-turn-helix domains; Region: HTH; cl00088 315730011548 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 315730011549 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 315730011550 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 315730011551 active site residue [active] 315730011552 Transcriptional regulators [Transcription]; Region: PurR; COG1609 315730011553 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315730011554 DNA binding site [nucleotide binding] 315730011555 domain linker motif; other site 315730011556 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 315730011557 putative dimerization interface [polypeptide binding]; other site 315730011558 putative ligand binding site [chemical binding]; other site 315730011559 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730011560 Helix-turn-helix domains; Region: HTH; cl00088 315730011561 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 315730011562 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 315730011563 Protein of unknown function (DUF3975); Region: DUF3975; pfam13126 315730011564 Domain of unknown function (DUF202); Region: DUF202; cl09954 315730011565 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 315730011566 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 315730011567 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 315730011568 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315730011569 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 315730011570 Walker A/P-loop; other site 315730011571 ATP binding site [chemical binding]; other site 315730011572 Q-loop/lid; other site 315730011573 ABC transporter signature motif; other site 315730011574 Walker B; other site 315730011575 D-loop; other site 315730011576 H-loop/switch region; other site 315730011577 Predicted transcriptional regulators [Transcription]; Region: COG1725 315730011578 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730011579 DNA-binding site [nucleotide binding]; DNA binding site 315730011580 Protein of unknown function (DUF3929); Region: DUF3929; pfam13066 315730011581 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 315730011582 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 315730011583 tetramer interface [polypeptide binding]; other site 315730011584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730011585 catalytic residue [active] 315730011586 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 315730011587 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 315730011588 tetramer interface [polypeptide binding]; other site 315730011589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730011590 catalytic residue [active] 315730011591 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 315730011592 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 315730011593 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 315730011594 DEAD-like helicases superfamily; Region: DEXDc; smart00487 315730011595 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315730011596 ATP binding site [chemical binding]; other site 315730011597 putative Mg++ binding site [ion binding]; other site 315730011598 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315730011599 nucleotide binding region [chemical binding]; other site 315730011600 ATP-binding site [chemical binding]; other site 315730011601 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 315730011602 YqzE-like protein; Region: YqzE; pfam14038 315730011603 shikimate kinase; Reviewed; Region: aroK; PRK00131 315730011604 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 315730011605 ADP binding site [chemical binding]; other site 315730011606 magnesium binding site [ion binding]; other site 315730011607 putative shikimate binding site; other site 315730011608 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 315730011609 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 315730011610 ComG operon protein 7; Region: ComGG; pfam14173 315730011611 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 315730011612 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 315730011613 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 315730011614 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 315730011615 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 315730011616 Type II/IV secretion system protein; Region: T2SE; pfam00437 315730011617 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730011618 Walker A motif; other site 315730011619 ATP binding site [chemical binding]; other site 315730011620 Walker B motif; other site 315730011621 Predicted transcriptional regulator [Transcription]; Region: COG2345 315730011622 Helix-turn-helix domains; Region: HTH; cl00088 315730011623 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 315730011624 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 315730011625 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 315730011626 Protein of unknown function (DUF3912); Region: DUF3912; pfam13051 315730011627 TIR domain; Region: TIR_2; cl15770 315730011628 Protein of unknown function (DUF3966); Region: DUF3966; pfam13110 315730011629 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 315730011630 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 315730011631 active site 315730011632 homodimer interface [polypeptide binding]; other site 315730011633 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 315730011634 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 315730011635 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 315730011636 substrate binding pocket [chemical binding]; other site 315730011637 dimer interface [polypeptide binding]; other site 315730011638 inhibitor binding site; inhibition site 315730011639 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 315730011640 B12 binding site [chemical binding]; other site 315730011641 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 315730011642 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 315730011643 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 315730011644 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 315730011645 FAD binding site [chemical binding]; other site 315730011646 cystathionine gamma-synthase; Reviewed; Region: PRK08247 315730011647 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 315730011648 homodimer interface [polypeptide binding]; other site 315730011649 substrate-cofactor binding pocket; other site 315730011650 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730011651 catalytic residue [active] 315730011652 cystathionine beta-lyase; Provisional; Region: PRK08064 315730011653 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 315730011654 homodimer interface [polypeptide binding]; other site 315730011655 substrate-cofactor binding pocket; other site 315730011656 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730011657 catalytic residue [active] 315730011658 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730011659 dimerization interface [polypeptide binding]; other site 315730011660 putative DNA binding site [nucleotide binding]; other site 315730011661 putative Zn2+ binding site [ion binding]; other site 315730011662 Uncharacterized conserved protein [Function unknown]; Region: COG1565 315730011663 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 315730011664 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315730011665 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 315730011666 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 315730011667 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 315730011668 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 315730011669 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 315730011670 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 315730011671 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 315730011672 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 315730011673 active site 315730011674 Substrate binding site; other site 315730011675 Mg++ binding site; other site 315730011676 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 315730011677 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 315730011678 putative trimer interface [polypeptide binding]; other site 315730011679 putative CoA binding site [chemical binding]; other site 315730011680 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 315730011681 active site 315730011682 substrate binding site [chemical binding]; other site 315730011683 metal binding site [ion binding]; metal-binding site 315730011684 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 315730011685 PhoU domain; Region: PhoU; pfam01895 315730011686 PhoU domain; Region: PhoU; pfam01895 315730011687 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 315730011688 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 315730011689 Walker A/P-loop; other site 315730011690 ATP binding site [chemical binding]; other site 315730011691 Q-loop/lid; other site 315730011692 ABC transporter signature motif; other site 315730011693 Walker B; other site 315730011694 D-loop; other site 315730011695 H-loop/switch region; other site 315730011696 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 315730011697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730011698 dimer interface [polypeptide binding]; other site 315730011699 conserved gate region; other site 315730011700 putative PBP binding loops; other site 315730011701 ABC-ATPase subunit interface; other site 315730011702 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 315730011703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730011704 dimer interface [polypeptide binding]; other site 315730011705 conserved gate region; other site 315730011706 putative PBP binding loops; other site 315730011707 ABC-ATPase subunit interface; other site 315730011708 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 315730011709 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 315730011710 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315730011711 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730011712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730011713 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730011714 putative substrate translocation pore; other site 315730011715 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 315730011716 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 315730011717 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 315730011718 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 315730011719 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 315730011720 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 315730011721 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 315730011722 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 315730011723 metal binding site 2 [ion binding]; metal-binding site 315730011724 putative DNA binding helix; other site 315730011725 metal binding site 1 [ion binding]; metal-binding site 315730011726 dimer interface [polypeptide binding]; other site 315730011727 structural Zn2+ binding site [ion binding]; other site 315730011728 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315730011729 ABC-ATPase subunit interface; other site 315730011730 dimer interface [polypeptide binding]; other site 315730011731 putative PBP binding regions; other site 315730011732 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 315730011733 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 315730011734 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315730011735 Uncharacterized conserved protein [Function unknown]; Region: COG1284 315730011736 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 315730011737 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 315730011738 endonuclease IV; Provisional; Region: PRK01060 315730011739 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 315730011740 AP (apurinic/apyrimidinic) site pocket; other site 315730011741 DNA interaction; other site 315730011742 Metal-binding active site; metal-binding site 315730011743 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 315730011744 DEAD-like helicases superfamily; Region: DEXDc; smart00487 315730011745 ATP binding site [chemical binding]; other site 315730011746 Mg++ binding site [ion binding]; other site 315730011747 motif III; other site 315730011748 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315730011749 nucleotide binding region [chemical binding]; other site 315730011750 ATP-binding site [chemical binding]; other site 315730011751 YqfQ-like protein; Region: YqfQ; pfam14181 315730011752 LytB protein; Region: LYTB; cl00507 315730011753 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 315730011754 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 315730011755 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 315730011756 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 315730011757 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730011758 Cytochrome c; Region: Cytochrom_C; cl11414 315730011759 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 315730011760 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 315730011761 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 315730011762 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730011763 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 315730011764 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730011765 DNA binding residues [nucleotide binding] 315730011766 DNA primase; Validated; Region: dnaG; PRK05667 315730011767 CHC2 zinc finger; Region: zf-CHC2; cl15369 315730011768 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 315730011769 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 315730011770 active site 315730011771 metal binding site [ion binding]; metal-binding site 315730011772 interdomain interaction site; other site 315730011773 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 315730011774 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 315730011775 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 315730011776 Helix-turn-helix domains; Region: HTH; cl00088 315730011777 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 315730011778 FOG: CBS domain [General function prediction only]; Region: COG0517 315730011779 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 315730011780 Recombination protein O N terminal; Region: RecO_N; cl15812 315730011781 Recombination protein O C terminal; Region: RecO_C; pfam02565 315730011782 YqzL-like protein; Region: YqzL; pfam14006 315730011783 GTPase Era; Reviewed; Region: era; PRK00089 315730011784 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 315730011785 G1 box; other site 315730011786 GTP/Mg2+ binding site [chemical binding]; other site 315730011787 Switch I region; other site 315730011788 G2 box; other site 315730011789 Switch II region; other site 315730011790 G3 box; other site 315730011791 G4 box; other site 315730011792 G5 box; other site 315730011793 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 315730011794 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 315730011795 active site 315730011796 catalytic motif [active] 315730011797 Zn binding site [ion binding]; other site 315730011798 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 315730011799 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 315730011800 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 315730011801 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 315730011802 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 315730011803 Zn2+ binding site [ion binding]; other site 315730011804 Mg2+ binding site [ion binding]; other site 315730011805 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 315730011806 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730011807 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 315730011808 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 315730011809 YabP family; Region: YabP; cl06766 315730011810 GatB domain; Region: GatB_Yqey; cl11497 315730011811 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 315730011812 radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089 315730011813 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 315730011814 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315730011815 FeS/SAM binding site; other site 315730011816 TRAM domain; Region: TRAM; cl01282 315730011817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 315730011818 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 315730011819 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 315730011820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730011821 S-adenosylmethionine binding site [chemical binding]; other site 315730011822 chaperone protein DnaJ; Provisional; Region: PRK14280 315730011823 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 315730011824 HSP70 interaction site [polypeptide binding]; other site 315730011825 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 315730011826 substrate binding site [polypeptide binding]; other site 315730011827 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 315730011828 Zn binding sites [ion binding]; other site 315730011829 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 315730011830 dimer interface [polypeptide binding]; other site 315730011831 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 315730011832 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 315730011833 heat shock protein GrpE; Provisional; Region: PRK14140 315730011834 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 315730011835 dimer interface [polypeptide binding]; other site 315730011836 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 315730011837 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 315730011838 Helix-turn-helix domains; Region: HTH; cl00088 315730011839 HrcA protein C terminal domain; Region: HrcA; pfam01628 315730011840 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 315730011841 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315730011842 FeS/SAM binding site; other site 315730011843 HemN C-terminal domain; Region: HemN_C; pfam06969 315730011844 Helix-turn-helix domains; Region: HTH; cl00088 315730011845 GTP-binding protein LepA; Provisional; Region: PRK05433 315730011846 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 315730011847 G1 box; other site 315730011848 putative GEF interaction site [polypeptide binding]; other site 315730011849 GTP/Mg2+ binding site [chemical binding]; other site 315730011850 Switch I region; other site 315730011851 G2 box; other site 315730011852 G3 box; other site 315730011853 Switch II region; other site 315730011854 G4 box; other site 315730011855 G5 box; other site 315730011856 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 315730011857 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 315730011858 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 315730011859 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 315730011860 Germination protease; Region: Peptidase_A25; cl04057 315730011861 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 315730011862 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 315730011863 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 315730011864 YqzM-like protein; Region: YqzM; pfam14141 315730011865 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 315730011866 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 315730011867 Competence protein; Region: Competence; cl00471 315730011868 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315730011869 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 315730011870 catalytic motif [active] 315730011871 Zn binding site [ion binding]; other site 315730011872 SLBB domain; Region: SLBB; pfam10531 315730011873 comEA protein; Region: comE; TIGR01259 315730011874 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 315730011875 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730011876 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 315730011877 ubiquinone biosynthesis O-methyltransferase; Region: UbiG; TIGR01983 315730011878 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730011879 S-adenosylmethionine binding site [chemical binding]; other site 315730011880 Oligomerisation domain; Region: Oligomerisation; cl00519 315730011881 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 315730011882 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 315730011883 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 315730011884 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 315730011885 active site 315730011886 (T/H)XGH motif; other site 315730011887 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 315730011888 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 315730011889 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 315730011890 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 315730011891 shikimate binding site; other site 315730011892 NAD(P) binding site [chemical binding]; other site 315730011893 GTPase YqeH; Provisional; Region: PRK13796 315730011894 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 315730011895 GTP/Mg2+ binding site [chemical binding]; other site 315730011896 G4 box; other site 315730011897 G5 box; other site 315730011898 G1 box; other site 315730011899 Switch I region; other site 315730011900 G2 box; other site 315730011901 G3 box; other site 315730011902 Switch II region; other site 315730011903 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 315730011904 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730011905 active site 315730011906 motif I; other site 315730011907 motif II; other site 315730011908 Sporulation inhibitor A; Region: Sda; pfam08970 315730011909 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 315730011910 sporulation sigma factor SigK; Reviewed; Region: PRK05803 315730011911 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730011912 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730011913 DNA binding residues [nucleotide binding] 315730011914 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 315730011915 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 315730011916 synthetase active site [active] 315730011917 NTP binding site [chemical binding]; other site 315730011918 metal binding site [ion binding]; metal-binding site 315730011919 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 315730011920 dimer interface [polypeptide binding]; other site 315730011921 Alkaline phosphatase homologues; Region: alkPPc; smart00098 315730011922 active site 315730011923 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730011924 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730011925 Coenzyme A binding pocket [chemical binding]; other site 315730011926 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315730011927 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730011928 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 315730011929 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 315730011930 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 315730011931 putative active site [active] 315730011932 catalytic triad [active] 315730011933 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 315730011934 putative integrin binding motif; other site 315730011935 PA/protease domain interface [polypeptide binding]; other site 315730011936 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 315730011937 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK05842 315730011938 FlgD Ig-like domain; Region: FlgD_ig; cl15790 315730011939 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 315730011940 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 315730011941 cofactor binding site; other site 315730011942 metal binding site [ion binding]; metal-binding site 315730011943 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 315730011944 aromatic arch; other site 315730011945 DCoH dimer interaction site [polypeptide binding]; other site 315730011946 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 315730011947 DCoH tetramer interaction site [polypeptide binding]; other site 315730011948 substrate binding site [chemical binding]; other site 315730011949 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 315730011950 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 315730011951 putative metal binding site [ion binding]; other site 315730011952 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 315730011953 active site 315730011954 metal binding site [ion binding]; metal-binding site 315730011955 DoxX; Region: DoxX; cl00976 315730011956 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 315730011957 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730011958 non-specific DNA binding site [nucleotide binding]; other site 315730011959 salt bridge; other site 315730011960 sequence-specific DNA binding site [nucleotide binding]; other site 315730011961 Cupin domain; Region: Cupin_2; cl09118 315730011962 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 315730011963 active site 2 [active] 315730011964 active site 1 [active] 315730011965 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730011966 Coenzyme A binding pocket [chemical binding]; other site 315730011967 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 315730011968 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730011969 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 315730011970 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 315730011971 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 315730011972 Walker A/P-loop; other site 315730011973 ATP binding site [chemical binding]; other site 315730011974 Q-loop/lid; other site 315730011975 ABC transporter signature motif; other site 315730011976 Walker B; other site 315730011977 D-loop; other site 315730011978 H-loop/switch region; other site 315730011979 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315730011980 ABC-ATPase subunit interface; other site 315730011981 dimer interface [polypeptide binding]; other site 315730011982 putative PBP binding regions; other site 315730011983 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 315730011984 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 315730011985 intersubunit interface [polypeptide binding]; other site 315730011986 YrhC-like protein; Region: YrhC; pfam14143 315730011987 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 315730011988 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 315730011989 putative catalytic cysteine [active] 315730011990 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 315730011991 putative active site [active] 315730011992 metal binding site [ion binding]; metal-binding site 315730011993 cystathionine beta-lyase; Provisional; Region: PRK07671 315730011994 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 315730011995 homodimer interface [polypeptide binding]; other site 315730011996 substrate-cofactor binding pocket; other site 315730011997 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730011998 catalytic residue [active] 315730011999 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 315730012000 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 315730012001 dimer interface [polypeptide binding]; other site 315730012002 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730012003 catalytic residue [active] 315730012004 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 315730012005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730012006 S-adenosylmethionine binding site [chemical binding]; other site 315730012007 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 315730012008 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 315730012009 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 315730012010 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 315730012011 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730012012 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 315730012013 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 315730012014 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 315730012015 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 315730012016 ATP-binding site [chemical binding]; other site 315730012017 Sugar specificity; other site 315730012018 Pyrimidine base specificity; other site 315730012019 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 315730012020 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 315730012021 Peptidase family U32; Region: Peptidase_U32; cl03113 315730012022 Protein of unknown function (DUF556); Region: DUF556; cl00822 315730012023 Peptidase family U32; Region: Peptidase_U32; cl03113 315730012024 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 315730012025 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730012026 S-adenosylmethionine binding site [chemical binding]; other site 315730012027 YceG-like family; Region: YceG; pfam02618 315730012028 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 315730012029 dimerization interface [polypeptide binding]; other site 315730012030 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 315730012031 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 315730012032 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 315730012033 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 315730012034 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 315730012035 motif 1; other site 315730012036 active site 315730012037 motif 2; other site 315730012038 motif 3; other site 315730012039 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 315730012040 DHHA1 domain; Region: DHHA1; pfam02272 315730012041 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 315730012042 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 315730012043 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 315730012044 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 315730012045 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730012046 Family description; Region: UvrD_C_2; cl15862 315730012047 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730012048 binding surface 315730012049 TPR motif; other site 315730012050 TPR repeat; Region: TPR_11; pfam13414 315730012051 TPR repeat; Region: TPR_11; pfam13414 315730012052 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730012053 binding surface 315730012054 TPR motif; other site 315730012055 TPR repeat; Region: TPR_11; pfam13414 315730012056 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 315730012057 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 315730012058 Ligand Binding Site [chemical binding]; other site 315730012059 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 315730012060 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 315730012061 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 315730012062 catalytic residue [active] 315730012063 Predicted transcriptional regulator [Transcription]; Region: COG1959 315730012064 Helix-turn-helix domains; Region: HTH; cl00088 315730012065 recombination factor protein RarA; Reviewed; Region: PRK13342 315730012066 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730012067 Walker A motif; other site 315730012068 ATP binding site [chemical binding]; other site 315730012069 Walker B motif; other site 315730012070 arginine finger; other site 315730012071 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 315730012072 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 315730012073 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 315730012074 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 315730012075 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 315730012076 putative ATP binding site [chemical binding]; other site 315730012077 putative substrate interface [chemical binding]; other site 315730012078 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 315730012079 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 315730012080 dimer interface [polypeptide binding]; other site 315730012081 anticodon binding site; other site 315730012082 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 315730012083 homodimer interface [polypeptide binding]; other site 315730012084 motif 1; other site 315730012085 active site 315730012086 motif 2; other site 315730012087 GAD domain; Region: GAD; pfam02938 315730012088 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 315730012089 motif 3; other site 315730012090 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 315730012091 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 315730012092 dimer interface [polypeptide binding]; other site 315730012093 motif 1; other site 315730012094 active site 315730012095 motif 2; other site 315730012096 motif 3; other site 315730012097 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 315730012098 anticodon binding site; other site 315730012099 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 315730012100 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 315730012101 putative active site [active] 315730012102 dimerization interface [polypeptide binding]; other site 315730012103 putative tRNAtyr binding site [nucleotide binding]; other site 315730012104 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 315730012105 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 315730012106 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 315730012107 synthetase active site [active] 315730012108 NTP binding site [chemical binding]; other site 315730012109 metal binding site [ion binding]; metal-binding site 315730012110 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 315730012111 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 315730012112 Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503 315730012113 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315730012114 active site 315730012115 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 315730012116 DHH family; Region: DHH; pfam01368 315730012117 DHHA1 domain; Region: DHHA1; pfam02272 315730012118 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 315730012119 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 315730012120 Cation efflux family; Region: Cation_efflux; cl00316 315730012121 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 315730012122 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 315730012123 Protein export membrane protein; Region: SecD_SecF; cl14618 315730012124 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 315730012125 Protein export membrane protein; Region: SecD_SecF; cl14618 315730012126 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 315730012127 stage V sporulation protein B; Region: spore_V_B; TIGR02900 315730012128 MatE; Region: MatE; cl10513 315730012129 MatE; Region: MatE; cl10513 315730012130 Protein of unknown function (DUF421); Region: DUF421; cl00990 315730012131 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 315730012132 Preprotein translocase subunit; Region: YajC; cl00806 315730012133 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 315730012134 tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449 315730012135 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 315730012136 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 315730012137 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 315730012138 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 315730012139 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730012140 Walker A motif; other site 315730012141 ATP binding site [chemical binding]; other site 315730012142 Walker B motif; other site 315730012143 arginine finger; other site 315730012144 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 315730012145 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 315730012146 RuvA N terminal domain; Region: RuvA_N; pfam01330 315730012147 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 315730012148 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 315730012149 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 315730012150 putative ligand binding residues [chemical binding]; other site 315730012151 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 315730012152 BofC C-terminal domain; Region: BofC_C; pfam08955 315730012153 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 315730012154 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 315730012155 putative peptidoglycan binding site; other site 315730012156 Quinolinate synthetase A protein; Region: NadA; cl00420 315730012157 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 315730012158 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 315730012159 dimerization interface [polypeptide binding]; other site 315730012160 active site 315730012161 L-aspartate oxidase; Provisional; Region: PRK08071 315730012162 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730012163 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 315730012164 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 315730012165 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 315730012166 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 315730012167 catalytic residue [active] 315730012168 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 315730012169 Helix-turn-helix domains; Region: HTH; cl00088 315730012170 3H domain; Region: 3H; pfam02829 315730012171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 315730012172 MOSC domain; Region: MOSC; pfam03473 315730012173 3-alpha domain; Region: 3-alpha; pfam03475 315730012174 prephenate dehydratase; Provisional; Region: PRK11898 315730012175 Prephenate dehydratase; Region: PDT; pfam00800 315730012176 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 315730012177 putative L-Phe binding site [chemical binding]; other site 315730012178 FtsX-like permease family; Region: FtsX; cl15850 315730012179 FtsX-like permease family; Region: FtsX; cl15850 315730012180 FtsX-like permease family; Region: FtsX; cl15850 315730012181 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730012182 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 315730012183 Walker A/P-loop; other site 315730012184 ATP binding site [chemical binding]; other site 315730012185 Q-loop/lid; other site 315730012186 ABC transporter signature motif; other site 315730012187 Walker B; other site 315730012188 D-loop; other site 315730012189 H-loop/switch region; other site 315730012190 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 315730012191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730012192 ATP binding site [chemical binding]; other site 315730012193 Mg2+ binding site [ion binding]; other site 315730012194 G-X-G motif; other site 315730012195 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730012196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730012197 active site 315730012198 phosphorylation site [posttranslational modification] 315730012199 intermolecular recognition site; other site 315730012200 dimerization interface [polypeptide binding]; other site 315730012201 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730012202 DNA binding site [nucleotide binding] 315730012203 GTPase CgtA; Reviewed; Region: obgE; PRK12297 315730012204 GTP1/OBG; Region: GTP1_OBG; pfam01018 315730012205 Obg GTPase; Region: Obg; cd01898 315730012206 G1 box; other site 315730012207 GTP/Mg2+ binding site [chemical binding]; other site 315730012208 Switch I region; other site 315730012209 G2 box; other site 315730012210 G3 box; other site 315730012211 Switch II region; other site 315730012212 G4 box; other site 315730012213 G5 box; other site 315730012214 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 315730012215 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 315730012216 Protein of unknown function (DUF464); Region: DUF464; cl01080 315730012217 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 315730012218 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 315730012219 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 315730012220 homodimer interface [polypeptide binding]; other site 315730012221 oligonucleotide binding site [chemical binding]; other site 315730012222 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 315730012223 active site 315730012224 putative substrate binding region [chemical binding]; other site 315730012225 Peptidase family M23; Region: Peptidase_M23; pfam01551 315730012226 septum site-determining protein MinD; Region: minD_bact; TIGR01968 315730012227 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 315730012228 Switch I; other site 315730012229 Switch II; other site 315730012230 septum formation inhibitor; Reviewed; Region: minC; PRK00513 315730012231 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 315730012232 rod shape-determining protein MreD; Region: MreD; cl01087 315730012233 rod shape-determining protein MreC; Provisional; Region: PRK13922 315730012234 rod shape-determining protein MreC; Region: MreC; pfam04085 315730012235 rod shape-determining protein MreB; Provisional; Region: PRK13927 315730012236 Cell division protein FtsA; Region: FtsA; cl11496 315730012237 hypothetical protein; Reviewed; Region: PRK00024 315730012238 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 315730012239 MPN+ (JAMM) motif; other site 315730012240 Zinc-binding site [ion binding]; other site 315730012241 Maf-like protein; Region: Maf; pfam02545 315730012242 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 315730012243 active site 315730012244 dimer interface [polypeptide binding]; other site 315730012245 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 315730012246 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 315730012247 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 315730012248 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 315730012249 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 315730012250 active site 315730012251 HIGH motif; other site 315730012252 nucleotide binding site [chemical binding]; other site 315730012253 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 315730012254 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 315730012255 active site 315730012256 KMSKS motif; other site 315730012257 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 315730012258 tRNA binding surface [nucleotide binding]; other site 315730012259 anticodon binding site; other site 315730012260 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 315730012261 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315730012262 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 315730012263 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 315730012264 putative peptidoglycan binding site; other site 315730012265 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 315730012266 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 315730012267 inhibitor-cofactor binding pocket; inhibition site 315730012268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730012269 catalytic residue [active] 315730012270 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 315730012271 dimer interface [polypeptide binding]; other site 315730012272 active site 315730012273 Schiff base residues; other site 315730012274 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 315730012275 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 315730012276 active site 315730012277 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 315730012278 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 315730012279 domain interfaces; other site 315730012280 active site 315730012281 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 315730012282 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 315730012283 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 315730012284 tRNA; other site 315730012285 putative tRNA binding site [nucleotide binding]; other site 315730012286 putative NADP binding site [chemical binding]; other site 315730012287 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 315730012288 Transcriptional regulators [Transcription]; Region: MarR; COG1846 315730012289 Helix-turn-helix domains; Region: HTH; cl00088 315730012290 OsmC-like protein; Region: OsmC; cl00767 315730012291 Predicted GTPase [General function prediction only]; Region: COG0218 315730012292 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 315730012293 G1 box; other site 315730012294 GTP/Mg2+ binding site [chemical binding]; other site 315730012295 Switch I region; other site 315730012296 G2 box; other site 315730012297 G3 box; other site 315730012298 Switch II region; other site 315730012299 G4 box; other site 315730012300 G5 box; other site 315730012301 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 315730012302 Found in ATP-dependent protease La (LON); Region: LON; smart00464 315730012303 Found in ATP-dependent protease La (LON); Region: LON; smart00464 315730012304 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730012305 Walker A motif; other site 315730012306 ATP binding site [chemical binding]; other site 315730012307 Walker B motif; other site 315730012308 arginine finger; other site 315730012309 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 315730012310 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 315730012311 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730012312 Walker A motif; other site 315730012313 ATP binding site [chemical binding]; other site 315730012314 Walker B motif; other site 315730012315 arginine finger; other site 315730012316 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 315730012317 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 315730012318 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 315730012319 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730012320 Walker A motif; other site 315730012321 ATP binding site [chemical binding]; other site 315730012322 Walker B motif; other site 315730012323 arginine finger; other site 315730012324 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 315730012325 trigger factor; Provisional; Region: tig; PRK01490 315730012326 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 315730012327 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 315730012328 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 315730012329 binding surface 315730012330 TPR motif; other site 315730012331 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 315730012332 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 315730012333 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 315730012334 active site 315730012335 metal binding site [ion binding]; metal-binding site 315730012336 homotetramer interface [polypeptide binding]; other site 315730012337 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 315730012338 active site 315730012339 dimerization interface [polypeptide binding]; other site 315730012340 ribonuclease PH; Reviewed; Region: rph; PRK00173 315730012341 Ribonuclease PH; Region: RNase_PH_bact; cd11362 315730012342 hexamer interface [polypeptide binding]; other site 315730012343 active site 315730012344 Sporulation and spore germination; Region: Germane; cl11253 315730012345 Spore germination protein [General function prediction only]; Region: COG5401 315730012346 Sporulation and spore germination; Region: Germane; cl11253 315730012347 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 315730012348 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 315730012349 DNA binding residues [nucleotide binding] 315730012350 dimerization interface [polypeptide binding]; other site 315730012351 putative uracil/xanthine transporter; Provisional; Region: PRK11412 315730012352 putative deaminase; Validated; Region: PRK06846 315730012353 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 315730012354 active site 315730012355 PspC domain; Region: PspC; cl00864 315730012356 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 315730012357 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730012358 non-specific DNA binding site [nucleotide binding]; other site 315730012359 salt bridge; other site 315730012360 sequence-specific DNA binding site [nucleotide binding]; other site 315730012361 Cupin domain; Region: Cupin_2; cl09118 315730012362 EamA-like transporter family; Region: EamA; cl01037 315730012363 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 315730012364 amphipathic channel; other site 315730012365 Asn-Pro-Ala signature motifs; other site 315730012366 Predicted transcriptional regulator [Transcription]; Region: COG1959 315730012367 Helix-turn-helix domains; Region: HTH; cl00088 315730012368 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 315730012369 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 315730012370 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730012371 Walker A/P-loop; other site 315730012372 ATP binding site [chemical binding]; other site 315730012373 Q-loop/lid; other site 315730012374 ABC transporter signature motif; other site 315730012375 Walker B; other site 315730012376 D-loop; other site 315730012377 H-loop/switch region; other site 315730012378 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 315730012379 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 315730012380 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 315730012381 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 315730012382 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 315730012383 ligand binding site [chemical binding]; other site 315730012384 flagellar motor protein MotA; Validated; Region: PRK08124 315730012385 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 315730012386 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 315730012387 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 315730012388 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 315730012389 active site 315730012390 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 315730012391 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 315730012392 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 315730012393 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 315730012394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730012395 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 315730012396 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 315730012397 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 315730012398 putative Iron-sulfur protein interface [polypeptide binding]; other site 315730012399 proximal heme binding site [chemical binding]; other site 315730012400 distal heme binding site [chemical binding]; other site 315730012401 putative dimer interface [polypeptide binding]; other site 315730012402 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 315730012403 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 315730012404 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 315730012405 GIY-YIG motif/motif A; other site 315730012406 active site 315730012407 catalytic site [active] 315730012408 putative DNA binding site [nucleotide binding]; other site 315730012409 metal binding site [ion binding]; metal-binding site 315730012410 UvrB/uvrC motif; Region: UVR; pfam02151 315730012411 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 315730012412 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 315730012413 catalytic residues [active] 315730012414 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 315730012415 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 315730012416 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 315730012417 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 315730012418 Ligand binding site [chemical binding]; other site 315730012419 Electron transfer flavoprotein domain; Region: ETF; pfam01012 315730012420 enoyl-CoA hydratase; Provisional; Region: PRK07658 315730012421 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 315730012422 substrate binding site [chemical binding]; other site 315730012423 oxyanion hole (OAH) forming residues; other site 315730012424 trimer interface [polypeptide binding]; other site 315730012425 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 315730012426 Helix-turn-helix domains; Region: HTH; cl00088 315730012427 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 315730012428 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 315730012429 AMP-binding enzyme; Region: AMP-binding; cl15778 315730012430 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315730012431 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 315730012432 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 315730012433 siderophore binding site; other site 315730012434 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 315730012435 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315730012436 ABC-ATPase subunit interface; other site 315730012437 dimer interface [polypeptide binding]; other site 315730012438 putative PBP binding regions; other site 315730012439 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315730012440 ABC-ATPase subunit interface; other site 315730012441 dimer interface [polypeptide binding]; other site 315730012442 putative PBP binding regions; other site 315730012443 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 315730012444 DinB superfamily; Region: DinB_2; pfam12867 315730012445 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315730012446 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 315730012447 Walker A/P-loop; other site 315730012448 ATP binding site [chemical binding]; other site 315730012449 Q-loop/lid; other site 315730012450 ABC transporter signature motif; other site 315730012451 Walker B; other site 315730012452 D-loop; other site 315730012453 H-loop/switch region; other site 315730012454 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730012455 dimer interface [polypeptide binding]; other site 315730012456 phosphorylation site [posttranslational modification] 315730012457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730012458 ATP binding site [chemical binding]; other site 315730012459 Mg2+ binding site [ion binding]; other site 315730012460 G-X-G motif; other site 315730012461 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730012462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730012463 active site 315730012464 phosphorylation site [posttranslational modification] 315730012465 intermolecular recognition site; other site 315730012466 dimerization interface [polypeptide binding]; other site 315730012467 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730012468 DNA binding site [nucleotide binding] 315730012469 Uncharacterized conserved protein (DUF2196); Region: DUF2196; cl02044 315730012470 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 315730012471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 315730012472 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 315730012473 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 315730012474 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730012475 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 315730012476 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 315730012477 active site 315730012478 catalytic site [active] 315730012479 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 315730012480 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 315730012481 Walker A/P-loop; other site 315730012482 ATP binding site [chemical binding]; other site 315730012483 Q-loop/lid; other site 315730012484 ABC transporter signature motif; other site 315730012485 Walker B; other site 315730012486 D-loop; other site 315730012487 H-loop/switch region; other site 315730012488 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315730012489 ABC-ATPase subunit interface; other site 315730012490 dimer interface [polypeptide binding]; other site 315730012491 putative PBP binding regions; other site 315730012492 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 315730012493 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 315730012494 intersubunit interface [polypeptide binding]; other site 315730012495 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 315730012496 heme-binding site [chemical binding]; other site 315730012497 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 315730012498 heme-binding site [chemical binding]; other site 315730012499 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 315730012500 heme-binding site [chemical binding]; other site 315730012501 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 315730012502 heme-binding site [chemical binding]; other site 315730012503 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 315730012504 heme-binding site [chemical binding]; other site 315730012505 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 315730012506 heme-binding site [chemical binding]; other site 315730012507 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 315730012508 heme-binding site [chemical binding]; other site 315730012509 heme uptake protein IsdC; Region: IsdC; TIGR03656 315730012510 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 315730012511 heme-binding site [chemical binding]; other site 315730012512 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 315730012513 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 315730012514 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 315730012515 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315730012516 RNA binding surface [nucleotide binding]; other site 315730012517 PseudoU_synth_RluF_like: Pseudouridine synthase, Escherichia coli RluF like. This group is comprised of bacterial proteins similar to Escherichia coli RluF. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to...; Region: PseudoU_synth_RluF; cd02554 315730012518 probable active site [active] 315730012519 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 315730012520 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 315730012521 Walker A/P-loop; other site 315730012522 ATP binding site [chemical binding]; other site 315730012523 Q-loop/lid; other site 315730012524 ABC transporter signature motif; other site 315730012525 Walker B; other site 315730012526 D-loop; other site 315730012527 H-loop/switch region; other site 315730012528 Smr domain; Region: Smr; cl02619 315730012529 hypothetical protein; Provisional; Region: PRK08609 315730012530 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 315730012531 active site 315730012532 primer binding site [nucleotide binding]; other site 315730012533 NTP binding site [chemical binding]; other site 315730012534 metal binding triad [ion binding]; metal-binding site 315730012535 LETM1-like protein; Region: LETM1; pfam07766 315730012536 Colicin V production protein; Region: Colicin_V; cl00567 315730012537 Cell division protein ZapA; Region: ZapA; cl01146 315730012538 ribonuclease HIII; Provisional; Region: PRK00996 315730012539 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 315730012540 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 315730012541 RNA/DNA hybrid binding site [nucleotide binding]; other site 315730012542 active site 315730012543 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 315730012544 HSP70 interaction site [polypeptide binding]; other site 315730012545 Tetratricopeptide repeat; Region: TPR_16; pfam13432 315730012546 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730012547 binding surface 315730012548 Tetratricopeptide repeat; Region: TPR_16; pfam13432 315730012549 TPR motif; other site 315730012550 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 315730012551 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 315730012552 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 315730012553 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 315730012554 stage V sporulation protein K; Region: spore_V_K; TIGR02881 315730012555 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730012556 Walker A motif; other site 315730012557 ATP binding site [chemical binding]; other site 315730012558 Walker B motif; other site 315730012559 arginine finger; other site 315730012560 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 315730012561 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 315730012562 putative dimer interface [polypeptide binding]; other site 315730012563 putative anticodon binding site; other site 315730012564 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 315730012565 homodimer interface [polypeptide binding]; other site 315730012566 motif 1; other site 315730012567 motif 2; other site 315730012568 active site 315730012569 motif 3; other site 315730012570 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 315730012571 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 315730012572 putative tRNA-binding site [nucleotide binding]; other site 315730012573 B3/4 domain; Region: B3_4; cl11458 315730012574 tRNA synthetase B5 domain; Region: B5; cl08394 315730012575 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 315730012576 dimer interface [polypeptide binding]; other site 315730012577 motif 1; other site 315730012578 motif 3; other site 315730012579 motif 2; other site 315730012580 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 315730012581 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 315730012582 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 315730012583 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 315730012584 dimer interface [polypeptide binding]; other site 315730012585 motif 1; other site 315730012586 active site 315730012587 motif 2; other site 315730012588 motif 3; other site 315730012589 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 315730012590 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 315730012591 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 315730012592 Small, acid-soluble spore protein I; Region: SSPI; cl07940 315730012593 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 315730012594 CAAX protease self-immunity; Region: Abi; cl00558 315730012595 ComEC family competence protein; Provisional; Region: PRK11539 315730012596 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 315730012597 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 315730012598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730012599 putative substrate translocation pore; other site 315730012600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730012601 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 315730012602 Helix-turn-helix domains; Region: HTH; cl00088 315730012603 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 315730012604 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 315730012605 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 315730012606 oligomer interface [polypeptide binding]; other site 315730012607 active site 315730012608 metal binding site [ion binding]; metal-binding site 315730012609 Dimeric dUTPase [Carbohydrate transport and metabolism]; Region: COG4508 315730012610 dUTPase; Region: dUTPase_2; pfam08761 315730012611 ribosomal protein L20; Region: rpl20; CHL00068 315730012612 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 315730012613 23S rRNA binding site [nucleotide binding]; other site 315730012614 L21 binding site [polypeptide binding]; other site 315730012615 L13 binding site [polypeptide binding]; other site 315730012616 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 315730012617 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 315730012618 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 315730012619 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 315730012620 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 315730012621 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 315730012622 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 315730012623 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 315730012624 active site 315730012625 dimer interface [polypeptide binding]; other site 315730012626 motif 1; other site 315730012627 motif 2; other site 315730012628 motif 3; other site 315730012629 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 315730012630 anticodon binding site; other site 315730012631 YtxC-like family; Region: YtxC; cl08500 315730012632 primosomal protein DnaI; Reviewed; Region: PRK08939 315730012633 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 315730012634 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730012635 Walker A motif; other site 315730012636 ATP binding site [chemical binding]; other site 315730012637 Walker B motif; other site 315730012638 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 315730012639 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 315730012640 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 315730012641 ATP cone domain; Region: ATP-cone; pfam03477 315730012642 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 315730012643 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 315730012644 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730012645 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 315730012646 dephospho-CoA kinase; Region: TIGR00152 315730012647 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 315730012648 CoA-binding site [chemical binding]; other site 315730012649 ATP-binding [chemical binding]; other site 315730012650 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 315730012651 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 315730012652 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 315730012653 DNA binding site [nucleotide binding] 315730012654 catalytic residue [active] 315730012655 H2TH interface [polypeptide binding]; other site 315730012656 putative catalytic residues [active] 315730012657 turnover-facilitating residue; other site 315730012658 intercalation triad [nucleotide binding]; other site 315730012659 8OG recognition residue [nucleotide binding]; other site 315730012660 putative reading head residues; other site 315730012661 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 315730012662 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 315730012663 DNA polymerase I; Provisional; Region: PRK05755 315730012664 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 315730012665 active site 315730012666 metal binding site 1 [ion binding]; metal-binding site 315730012667 putative 5' ssDNA interaction site; other site 315730012668 metal binding site 3; metal-binding site 315730012669 metal binding site 2 [ion binding]; metal-binding site 315730012670 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 315730012671 putative DNA binding site [nucleotide binding]; other site 315730012672 putative metal binding site [ion binding]; other site 315730012673 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 315730012674 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 315730012675 active site 315730012676 DNA binding site [nucleotide binding] 315730012677 catalytic site [active] 315730012678 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 315730012679 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 315730012680 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315730012681 putative active site [active] 315730012682 heme pocket [chemical binding]; other site 315730012683 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730012684 dimer interface [polypeptide binding]; other site 315730012685 phosphorylation site [posttranslational modification] 315730012686 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730012687 ATP binding site [chemical binding]; other site 315730012688 Mg2+ binding site [ion binding]; other site 315730012689 G-X-G motif; other site 315730012690 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730012691 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730012692 active site 315730012693 phosphorylation site [posttranslational modification] 315730012694 intermolecular recognition site; other site 315730012695 dimerization interface [polypeptide binding]; other site 315730012696 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730012697 DNA binding site [nucleotide binding] 315730012698 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 315730012699 dimer interaction site [polypeptide binding]; other site 315730012700 substrate-binding tunnel; other site 315730012701 active site 315730012702 catalytic site [active] 315730012703 substrate binding site [chemical binding]; other site 315730012704 malate dehydrogenase; Reviewed; Region: PRK06223 315730012705 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 315730012706 NAD(P) binding site [chemical binding]; other site 315730012707 dimer interface [polypeptide binding]; other site 315730012708 tetramer (dimer of dimers) interface [polypeptide binding]; other site 315730012709 substrate binding site [chemical binding]; other site 315730012710 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 315730012711 isocitrate dehydrogenase; Validated; Region: PRK07362 315730012712 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 315730012713 dimer interface [polypeptide binding]; other site 315730012714 Citrate synthase; Region: Citrate_synt; pfam00285 315730012715 active site 315730012716 citrylCoA binding site [chemical binding]; other site 315730012717 oxalacetate/citrate binding site [chemical binding]; other site 315730012718 coenzyme A binding site [chemical binding]; other site 315730012719 catalytic triad [active] 315730012720 Protein of unknown function (DUF441); Region: DUF441; cl01041 315730012721 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 315730012722 Domain of unknown function DUF20; Region: UPF0118; pfam01594 315730012723 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 315730012724 pyruvate kinase; Provisional; Region: PRK06354 315730012725 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 315730012726 domain interfaces; other site 315730012727 active site 315730012728 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 315730012729 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 315730012730 active site 315730012731 ADP/pyrophosphate binding site [chemical binding]; other site 315730012732 dimerization interface [polypeptide binding]; other site 315730012733 allosteric effector site; other site 315730012734 fructose-1,6-bisphosphate binding site; other site 315730012735 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 315730012736 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 315730012737 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 315730012738 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 315730012739 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 315730012740 Transcriptional regulators [Transcription]; Region: FadR; COG2186 315730012741 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730012742 DNA-binding site [nucleotide binding]; DNA binding site 315730012743 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 315730012744 Malic enzyme, N-terminal domain; Region: malic; pfam00390 315730012745 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 315730012746 putative NAD(P) binding site [chemical binding]; other site 315730012747 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 315730012748 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 315730012749 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 315730012750 generic binding surface II; other site 315730012751 generic binding surface I; other site 315730012752 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 315730012753 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 315730012754 DHH family; Region: DHH; pfam01368 315730012755 DHHA1 domain; Region: DHHA1; pfam02272 315730012756 YtpI-like protein; Region: YtpI; pfam14007 315730012757 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 315730012758 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 315730012759 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730012760 DNA-binding site [nucleotide binding]; DNA binding site 315730012761 DRTGG domain; Region: DRTGG; cl12147 315730012762 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 315730012763 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 315730012764 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315730012765 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 315730012766 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 315730012767 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 315730012768 active site 315730012769 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 315730012770 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 315730012771 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 315730012772 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730012773 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 315730012774 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730012775 Cupin domain; Region: Cupin_2; cl09118 315730012776 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 315730012777 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 315730012778 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730012779 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 315730012780 classical (c) SDRs; Region: SDR_c; cd05233 315730012781 NAD(P) binding site [chemical binding]; other site 315730012782 active site 315730012783 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 315730012784 Ligand Binding Site [chemical binding]; other site 315730012785 DinB superfamily; Region: DinB_2; pfam12867 315730012786 argininosuccinate lyase; Provisional; Region: PRK00855 315730012787 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 315730012788 active sites [active] 315730012789 tetramer interface [polypeptide binding]; other site 315730012790 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 315730012791 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 315730012792 ANP binding site [chemical binding]; other site 315730012793 Substrate Binding Site II [chemical binding]; other site 315730012794 Substrate Binding Site I [chemical binding]; other site 315730012795 membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Region: yidC_nterm; TIGR03593 315730012796 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315730012797 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315730012798 EcsC protein family; Region: EcsC; pfam12787 315730012799 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 315730012800 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 315730012801 nudix motif; other site 315730012802 Acetokinase family; Region: Acetate_kinase; cl01029 315730012803 propionate/acetate kinase; Provisional; Region: PRK12379 315730012804 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 315730012805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730012806 S-adenosylmethionine binding site [chemical binding]; other site 315730012807 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 315730012808 dimer interface [polypeptide binding]; other site 315730012809 catalytic triad [active] 315730012810 peroxidatic and resolving cysteines [active] 315730012811 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 315730012812 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 315730012813 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 315730012814 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 315730012815 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 315730012816 active site 315730012817 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730012818 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 315730012819 dimer interface [polypeptide binding]; other site 315730012820 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 315730012821 AMP-binding enzyme; Region: AMP-binding; cl15778 315730012822 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315730012823 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 315730012824 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 315730012825 THUMP domain; Region: THUMP; cl12076 315730012826 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 315730012827 Ligand Binding Site [chemical binding]; other site 315730012828 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 315730012829 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 315730012830 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 315730012831 catalytic residue [active] 315730012832 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 315730012833 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730012834 Helix-turn-helix domains; Region: HTH; cl00088 315730012835 GAF domain; Region: GAF; cl15785 315730012836 methionine gamma-lyase; Provisional; Region: PRK06767 315730012837 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 315730012838 homodimer interface [polypeptide binding]; other site 315730012839 substrate-cofactor binding pocket; other site 315730012840 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730012841 catalytic residue [active] 315730012842 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 315730012843 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 315730012844 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315730012845 RNA binding surface [nucleotide binding]; other site 315730012846 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 315730012847 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 315730012848 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 315730012849 active site 315730012850 HIGH motif; other site 315730012851 dimer interface [polypeptide binding]; other site 315730012852 KMSKS motif; other site 315730012853 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315730012854 RNA binding surface [nucleotide binding]; other site 315730012855 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 315730012856 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730012857 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730012858 DNA binding residues [nucleotide binding] 315730012859 maltose O-acetyltransferase; Provisional; Region: PRK10092 315730012860 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 315730012861 active site 315730012862 substrate binding site [chemical binding]; other site 315730012863 trimer interface [polypeptide binding]; other site 315730012864 CoA binding site [chemical binding]; other site 315730012865 acetyl-CoA synthetase; Provisional; Region: PRK04319 315730012866 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 315730012867 AMP-binding enzyme; Region: AMP-binding; cl15778 315730012868 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315730012869 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730012870 FOG: CBS domain [General function prediction only]; Region: COG0517 315730012871 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 315730012872 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 315730012873 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 315730012874 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 315730012875 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 315730012876 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 315730012877 active site 315730012878 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 315730012879 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730012880 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 315730012881 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 315730012882 Protein of unknown function (DUF3917); Region: DUF3917; pfam13055 315730012883 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 315730012884 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 315730012885 catabolite control protein A; Region: ccpA; TIGR01481 315730012886 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315730012887 DNA binding site [nucleotide binding] 315730012888 domain linker motif; other site 315730012889 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 315730012890 dimerization interface [polypeptide binding]; other site 315730012891 effector binding site; other site 315730012892 CamS sex pheromone cAM373 precursor; Region: CamS; cl11554 315730012893 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 315730012894 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 315730012895 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 315730012896 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 315730012897 bifunctional argininosuccinate lyase/N-acetylglutamate synthase; Provisional; Region: PRK12308 315730012898 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730012899 Coenzyme A binding pocket [chemical binding]; other site 315730012900 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730012901 Helix-turn-helix domains; Region: HTH; cl00088 315730012902 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 315730012903 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 315730012904 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 315730012905 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 315730012906 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 315730012907 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 315730012908 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 315730012909 active site 315730012910 DNA translocase FtsK; Provisional; Region: PRK10263 315730012911 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730012912 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 315730012913 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 315730012914 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 315730012915 active site 315730012916 metal binding site [ion binding]; metal-binding site 315730012917 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 315730012918 putative tRNA-binding site [nucleotide binding]; other site 315730012919 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 315730012920 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 315730012921 catalytic residues [active] 315730012922 Protein of unknown function DUF84; Region: NTPase_I-T; cl00866 315730012923 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 315730012924 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 315730012925 oligomer interface [polypeptide binding]; other site 315730012926 active site 315730012927 metal binding site [ion binding]; metal-binding site 315730012928 Predicted small secreted protein [Function unknown]; Region: COG5584 315730012929 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315730012930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730012931 S-adenosylmethionine binding site [chemical binding]; other site 315730012932 YtzH-like protein; Region: YtzH; pfam14165 315730012933 Phosphotransferase enzyme family; Region: APH; pfam01636 315730012934 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315730012935 active site 315730012936 substrate binding site [chemical binding]; other site 315730012937 ATP binding site [chemical binding]; other site 315730012938 pullulanase, type I; Region: pulA_typeI; TIGR02104 315730012939 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 315730012940 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 315730012941 Ca binding site [ion binding]; other site 315730012942 active site 315730012943 catalytic site [active] 315730012944 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 315730012945 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 315730012946 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 315730012947 dipeptidase PepV; Reviewed; Region: PRK07318 315730012948 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 315730012949 active site 315730012950 metal binding site [ion binding]; metal-binding site 315730012951 Helix-turn-helix domains; Region: HTH; cl00088 315730012952 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 315730012953 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315730012954 RNA binding surface [nucleotide binding]; other site 315730012955 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 315730012956 active site 315730012957 uracil binding [chemical binding]; other site 315730012958 stage V sporulation protein B; Region: spore_V_B; TIGR02900 315730012959 MatE; Region: MatE; cl10513 315730012960 HI0933-like protein; Region: HI0933_like; pfam03486 315730012961 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730012962 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730012963 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 315730012964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730012965 putative substrate translocation pore; other site 315730012966 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730012967 dimerization interface [polypeptide binding]; other site 315730012968 putative DNA binding site [nucleotide binding]; other site 315730012969 putative Zn2+ binding site [ion binding]; other site 315730012970 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 315730012971 putative hydrophobic ligand binding site [chemical binding]; other site 315730012972 Domain of unknown function (DUF3973); Region: DUF3973; pfam13119 315730012973 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 315730012974 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 315730012975 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 315730012976 glucose-1-dehydrogenase; Provisional; Region: PRK08936 315730012977 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 315730012978 NAD binding site [chemical binding]; other site 315730012979 homodimer interface [polypeptide binding]; other site 315730012980 active site 315730012981 Sugar transport protein; Region: Sugar_transport; pfam06800 315730012982 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 315730012983 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 315730012984 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 315730012985 MoaE interaction surface [polypeptide binding]; other site 315730012986 MoeB interaction surface [polypeptide binding]; other site 315730012987 thiocarboxylated glycine; other site 315730012988 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 315730012989 MoaE homodimer interface [polypeptide binding]; other site 315730012990 MoaD interaction [polypeptide binding]; other site 315730012991 active site residues [active] 315730012992 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 315730012993 Walker A motif; other site 315730012994 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 315730012995 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 315730012996 dimer interface [polypeptide binding]; other site 315730012997 putative functional site; other site 315730012998 putative MPT binding site; other site 315730012999 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 315730013000 trimer interface [polypeptide binding]; other site 315730013001 dimer interface [polypeptide binding]; other site 315730013002 putative active site [active] 315730013003 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 315730013004 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 315730013005 ATP binding site [chemical binding]; other site 315730013006 substrate interface [chemical binding]; other site 315730013007 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 315730013008 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315730013009 FeS/SAM binding site; other site 315730013010 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 315730013011 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 315730013012 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 315730013013 active site residue [active] 315730013014 homoserine O-acetyltransferase; Provisional; Region: PRK06765 315730013015 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315730013016 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 315730013017 Spore germination protein; Region: Spore_permease; cl15802 315730013018 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 315730013019 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 315730013020 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730013021 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 315730013022 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 315730013023 HIGH motif; other site 315730013024 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 315730013025 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 315730013026 active site 315730013027 KMSKS motif; other site 315730013028 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 315730013029 tRNA binding surface [nucleotide binding]; other site 315730013030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730013031 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730013032 putative substrate translocation pore; other site 315730013033 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 315730013034 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 315730013035 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 315730013036 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 315730013037 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 315730013038 Int/Topo IB signature motif; other site 315730013039 FtsX-like permease family; Region: FtsX; cl15850 315730013040 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730013041 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 315730013042 Walker A/P-loop; other site 315730013043 ATP binding site [chemical binding]; other site 315730013044 Q-loop/lid; other site 315730013045 ABC transporter signature motif; other site 315730013046 Walker B; other site 315730013047 D-loop; other site 315730013048 H-loop/switch region; other site 315730013049 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 315730013050 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 315730013051 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315730013052 FeS/SAM binding site; other site 315730013053 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730013054 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730013055 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 315730013056 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 315730013057 Walker A/P-loop; other site 315730013058 ATP binding site [chemical binding]; other site 315730013059 Q-loop/lid; other site 315730013060 ABC transporter signature motif; other site 315730013061 Walker B; other site 315730013062 D-loop; other site 315730013063 H-loop/switch region; other site 315730013064 aspartate racemase; Region: asp_race; TIGR00035 315730013065 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 315730013066 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 315730013067 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 315730013068 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 315730013069 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 315730013070 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 315730013071 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315730013072 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315730013073 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 315730013074 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 315730013075 trimer interface [polypeptide binding]; other site 315730013076 putative metal binding site [ion binding]; other site 315730013077 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 315730013078 active site 315730013079 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315730013080 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 315730013081 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 315730013082 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 315730013083 GTP binding site; other site 315730013084 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 315730013085 MPT binding site; other site 315730013086 trimer interface [polypeptide binding]; other site 315730013087 S-adenosylmethionine synthetase; Validated; Region: PRK05250 315730013088 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 315730013089 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 315730013090 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 315730013091 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 315730013092 active site 315730013093 substrate-binding site [chemical binding]; other site 315730013094 metal-binding site [ion binding] 315730013095 ATP binding site [chemical binding]; other site 315730013096 ATP synthase I chain; Region: ATP_synt_I; cl09170 315730013097 EamA-like transporter family; Region: EamA; cl01037 315730013098 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 315730013099 EamA-like transporter family; Region: EamA; cl01037 315730013100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 315730013101 sensory histidine kinase AtoS; Provisional; Region: PRK11360 315730013102 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730013103 ATP binding site [chemical binding]; other site 315730013104 Mg2+ binding site [ion binding]; other site 315730013105 G-X-G motif; other site 315730013106 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730013107 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730013108 dimer interface [polypeptide binding]; other site 315730013109 phosphorylation site [posttranslational modification] 315730013110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730013111 ATP binding site [chemical binding]; other site 315730013112 Mg2+ binding site [ion binding]; other site 315730013113 G-X-G motif; other site 315730013114 hydroperoxidase II; Provisional; Region: katE; PRK11249 315730013115 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 315730013116 heme binding pocket [chemical binding]; other site 315730013117 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 315730013118 domain interactions; other site 315730013119 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730013120 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 315730013121 Sulfatase; Region: Sulfatase; cl10460 315730013122 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 315730013123 Uncharacterized conserved protein (DUF2196); Region: DUF2196; cl02044 315730013124 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 315730013125 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 315730013126 NMT1-like family; Region: NMT1_2; cl15260 315730013127 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 315730013128 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 315730013129 Walker A/P-loop; other site 315730013130 ATP binding site [chemical binding]; other site 315730013131 Q-loop/lid; other site 315730013132 ABC transporter signature motif; other site 315730013133 Walker B; other site 315730013134 D-loop; other site 315730013135 H-loop/switch region; other site 315730013136 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 315730013137 dimer interface [polypeptide binding]; other site 315730013138 conserved gate region; other site 315730013139 putative PBP binding loops; other site 315730013140 ABC-ATPase subunit interface; other site 315730013141 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 315730013142 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730013143 motif II; other site 315730013144 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 315730013145 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 315730013146 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 315730013147 nudix motif; other site 315730013148 Tumour necrosis factor receptor superfamily member 19; Region: RELT; pfam12606 315730013149 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 315730013150 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 315730013151 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 315730013152 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 315730013153 Haemolytic domain; Region: Haemolytic; cl00506 315730013154 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 315730013155 active site clefts [active] 315730013156 zinc binding site [ion binding]; other site 315730013157 dimer interface [polypeptide binding]; other site 315730013158 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 315730013159 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 315730013160 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 315730013161 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 315730013162 S-layer homology domain; Region: SLH; pfam00395 315730013163 S-layer homology domain; Region: SLH; pfam00395 315730013164 S-layer homology domain; Region: SLH; pfam00395 315730013165 Excalibur calcium-binding domain; Region: Excalibur; cl05460 315730013166 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 315730013167 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 315730013168 putative active site [active] 315730013169 Uncharacterized conserved protein [Function unknown]; Region: COG1284 315730013170 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315730013171 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315730013172 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 315730013173 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 315730013174 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 315730013175 Predicted membrane protein [Function unknown]; Region: COG3766 315730013176 PspA/IM30 family; Region: PspA_IM30; pfam04012 315730013177 hypothetical protein; Provisional; Region: PRK06760; cl11698 315730013178 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 315730013179 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 315730013180 G1 box; other site 315730013181 GTP/Mg2+ binding site [chemical binding]; other site 315730013182 Switch I region; other site 315730013183 G2 box; other site 315730013184 G3 box; other site 315730013185 Switch II region; other site 315730013186 G4 box; other site 315730013187 G5 box; other site 315730013188 Nucleoside recognition; Region: Gate; cl00486 315730013189 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 315730013190 Nucleoside recognition; Region: Gate; cl00486 315730013191 FeoA domain; Region: FeoA; cl00838 315730013192 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 315730013193 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730013194 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730013195 dimerization interface [polypeptide binding]; other site 315730013196 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730013197 dimer interface [polypeptide binding]; other site 315730013198 phosphorylation site [posttranslational modification] 315730013199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730013200 ATP binding site [chemical binding]; other site 315730013201 Mg2+ binding site [ion binding]; other site 315730013202 G-X-G motif; other site 315730013203 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730013204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730013205 active site 315730013206 phosphorylation site [posttranslational modification] 315730013207 intermolecular recognition site; other site 315730013208 dimerization interface [polypeptide binding]; other site 315730013209 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730013210 DNA binding site [nucleotide binding] 315730013211 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 315730013212 active site 315730013213 catalytic site [active] 315730013214 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315730013215 active site 315730013216 lipid kinase, YegS/Rv2252/BmrU family; Region: TIGR00147 315730013217 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 315730013218 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 315730013219 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 315730013220 Cold-inducible protein YdjO; Region: YdjO; pfam14169 315730013221 FtsX-like permease family; Region: FtsX; cl15850 315730013222 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730013223 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 315730013224 Walker A/P-loop; other site 315730013225 ATP binding site [chemical binding]; other site 315730013226 Q-loop/lid; other site 315730013227 ABC transporter signature motif; other site 315730013228 Walker B; other site 315730013229 D-loop; other site 315730013230 H-loop/switch region; other site 315730013231 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 315730013232 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 315730013233 NodB motif; other site 315730013234 active site 315730013235 catalytic site [active] 315730013236 Zn binding site [ion binding]; other site 315730013237 FtsX-like permease family; Region: FtsX; cl15850 315730013238 rod shape-determining protein MreC; Region: MreC; pfam04085 315730013239 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 315730013240 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 315730013241 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730013242 dimerization interface [polypeptide binding]; other site 315730013243 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730013244 dimer interface [polypeptide binding]; other site 315730013245 phosphorylation site [posttranslational modification] 315730013246 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730013247 ATP binding site [chemical binding]; other site 315730013248 Mg2+ binding site [ion binding]; other site 315730013249 G-X-G motif; other site 315730013250 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730013251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730013252 active site 315730013253 phosphorylation site [posttranslational modification] 315730013254 intermolecular recognition site; other site 315730013255 dimerization interface [polypeptide binding]; other site 315730013256 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730013257 DNA binding site [nucleotide binding] 315730013258 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 315730013259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730013260 FtsX-like permease family; Region: FtsX; cl15850 315730013261 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730013262 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 315730013263 Walker A/P-loop; other site 315730013264 ATP binding site [chemical binding]; other site 315730013265 Q-loop/lid; other site 315730013266 ABC transporter signature motif; other site 315730013267 Walker B; other site 315730013268 D-loop; other site 315730013269 H-loop/switch region; other site 315730013270 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 315730013271 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 315730013272 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 315730013273 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 315730013274 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 315730013275 Walker A/P-loop; other site 315730013276 ATP binding site [chemical binding]; other site 315730013277 Q-loop/lid; other site 315730013278 ABC transporter signature motif; other site 315730013279 Walker B; other site 315730013280 D-loop; other site 315730013281 H-loop/switch region; other site 315730013282 Predicted integral membrane protein [Function unknown]; Region: COG5658 315730013283 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 315730013284 SdpI/YhfL protein family; Region: SdpI; pfam13630 315730013285 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730013286 dimerization interface [polypeptide binding]; other site 315730013287 putative DNA binding site [nucleotide binding]; other site 315730013288 putative Zn2+ binding site [ion binding]; other site 315730013289 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730013290 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730013291 active site 315730013292 phosphorylation site [posttranslational modification] 315730013293 intermolecular recognition site; other site 315730013294 dimerization interface [polypeptide binding]; other site 315730013295 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730013296 DNA binding site [nucleotide binding] 315730013297 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730013298 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 315730013299 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730013300 ATP binding site [chemical binding]; other site 315730013301 Mg2+ binding site [ion binding]; other site 315730013302 G-X-G motif; other site 315730013303 FtsX-like permease family; Region: FtsX; cl15850 315730013304 FtsX-like permease family; Region: FtsX; cl15850 315730013305 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730013306 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 315730013307 Walker A/P-loop; other site 315730013308 ATP binding site [chemical binding]; other site 315730013309 Q-loop/lid; other site 315730013310 ABC transporter signature motif; other site 315730013311 Walker B; other site 315730013312 D-loop; other site 315730013313 H-loop/switch region; other site 315730013314 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 315730013315 GntP family permease; Region: GntP_permease; pfam02447 315730013316 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 315730013317 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 315730013318 DNA-binding site [nucleotide binding]; DNA binding site 315730013319 UTRA domain; Region: UTRA; cl01230 315730013320 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 315730013321 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 315730013322 substrate binding site [chemical binding]; other site 315730013323 ATP binding site [chemical binding]; other site 315730013324 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 315730013325 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 315730013326 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 315730013327 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 315730013328 active site 315730013329 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 315730013330 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 315730013331 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730013332 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 315730013333 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730013334 dimer interface [polypeptide binding]; other site 315730013335 phosphorylation site [posttranslational modification] 315730013336 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730013337 ATP binding site [chemical binding]; other site 315730013338 Mg2+ binding site [ion binding]; other site 315730013339 G-X-G motif; other site 315730013340 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730013341 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730013342 active site 315730013343 phosphorylation site [posttranslational modification] 315730013344 intermolecular recognition site; other site 315730013345 dimerization interface [polypeptide binding]; other site 315730013346 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730013347 DNA binding site [nucleotide binding] 315730013348 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 315730013349 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 315730013350 active site 315730013351 octamer interface [polypeptide binding]; other site 315730013352 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 315730013353 AMP-binding enzyme; Region: AMP-binding; cl15778 315730013354 AMP-binding enzyme; Region: AMP-binding; cl15778 315730013355 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 315730013356 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 315730013357 substrate binding site [chemical binding]; other site 315730013358 oxyanion hole (OAH) forming residues; other site 315730013359 trimer interface [polypeptide binding]; other site 315730013360 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 315730013361 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 315730013362 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 315730013363 nucleophilic elbow; other site 315730013364 catalytic triad; other site 315730013365 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 315730013366 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 315730013367 dimer interface [polypeptide binding]; other site 315730013368 tetramer interface [polypeptide binding]; other site 315730013369 PYR/PP interface [polypeptide binding]; other site 315730013370 TPP binding site [chemical binding]; other site 315730013371 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 315730013372 TPP-binding site; other site 315730013373 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 315730013374 chorismate binding enzyme; Region: Chorismate_bind; cl10555 315730013375 UbiA prenyltransferase family; Region: UbiA; cl00337 315730013376 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 315730013377 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 315730013378 DNA-binding site [nucleotide binding]; DNA binding site 315730013379 RNA-binding motif; other site 315730013380 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 315730013381 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 315730013382 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315730013383 DNA binding residues [nucleotide binding] 315730013384 dimer interface [polypeptide binding]; other site 315730013385 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 315730013386 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation,' the process of...; Region: Lipase_3; cd00519 315730013387 active site flap/lid [active] 315730013388 nucleophilic elbow; other site 315730013389 catalytic triad [active] 315730013390 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 315730013391 homodimer interface [polypeptide binding]; other site 315730013392 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 315730013393 active site pocket [active] 315730013394 glycogen synthase; Provisional; Region: glgA; PRK00654 315730013395 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 315730013396 ADP-binding pocket [chemical binding]; other site 315730013397 homodimer interface [polypeptide binding]; other site 315730013398 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 315730013399 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 315730013400 ligand binding site; other site 315730013401 oligomer interface; other site 315730013402 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 315730013403 dimer interface [polypeptide binding]; other site 315730013404 N-terminal domain interface [polypeptide binding]; other site 315730013405 sulfate 1 binding site; other site 315730013406 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 315730013407 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 315730013408 ligand binding site; other site 315730013409 oligomer interface; other site 315730013410 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 315730013411 dimer interface [polypeptide binding]; other site 315730013412 N-terminal domain interface [polypeptide binding]; other site 315730013413 sulfate 1 binding site; other site 315730013414 glycogen branching enzyme; Provisional; Region: PRK12313 315730013415 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 315730013416 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 315730013417 active site 315730013418 catalytic site [active] 315730013419 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 315730013420 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 315730013421 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 315730013422 tetramer (dimer of dimers) interface [polypeptide binding]; other site 315730013423 NAD binding site [chemical binding]; other site 315730013424 dimer interface [polypeptide binding]; other site 315730013425 substrate binding site [chemical binding]; other site 315730013426 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 315730013427 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 315730013428 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730013429 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730013430 DNA binding residues [nucleotide binding] 315730013431 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 315730013432 MgtC family; Region: MgtC; pfam02308 315730013433 Ion channel; Region: Ion_trans_2; cl11596 315730013434 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 315730013435 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730013436 YugN-like family; Region: YugN; pfam08868 315730013437 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 315730013438 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 315730013439 active site 315730013440 dimer interface [polypeptide binding]; other site 315730013441 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 315730013442 dimer interface [polypeptide binding]; other site 315730013443 active site 315730013444 Domain of unknown function (DUF378); Region: DUF378; cl00943 315730013445 general stress protein 13; Validated; Region: PRK08059 315730013446 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 315730013447 RNA binding site [nucleotide binding]; other site 315730013448 hypothetical protein; Validated; Region: PRK07682 315730013449 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315730013450 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730013451 homodimer interface [polypeptide binding]; other site 315730013452 catalytic residue [active] 315730013453 Helix-turn-helix domains; Region: HTH; cl00088 315730013454 Helix-turn-helix domains; Region: HTH; cl00088 315730013455 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 315730013456 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730013457 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 315730013458 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 315730013459 nucleophilic elbow; other site 315730013460 catalytic triad; other site 315730013461 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 315730013462 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 315730013463 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 315730013464 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730013465 homodimer interface [polypeptide binding]; other site 315730013466 catalytic residue [active] 315730013467 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 315730013468 E-class dimer interface [polypeptide binding]; other site 315730013469 P-class dimer interface [polypeptide binding]; other site 315730013470 active site 315730013471 Cu2+ binding site [ion binding]; other site 315730013472 Zn2+ binding site [ion binding]; other site 315730013473 Kinase associated protein B; Region: KapB; pfam08810 315730013474 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 315730013475 active site 315730013476 substrate binding site [chemical binding]; other site 315730013477 catalytic site [active] 315730013478 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 315730013479 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 315730013480 transmembrane helices; other site 315730013481 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 315730013482 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 315730013483 active site 315730013484 glycyl-tRNA synthetase; Provisional; Region: PRK04173 315730013485 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 315730013486 motif 1; other site 315730013487 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 315730013488 active site 315730013489 motif 2; other site 315730013490 motif 3; other site 315730013491 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 315730013492 anticodon binding site; other site 315730013493 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 315730013494 CoenzymeA binding site [chemical binding]; other site 315730013495 subunit interaction site [polypeptide binding]; other site 315730013496 PHB binding site; other site 315730013497 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 315730013498 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 315730013499 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 315730013500 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 315730013501 active site 315730013502 tetramer interface; other site 315730013503 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 315730013504 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 315730013505 active site 315730013506 substrate binding site [chemical binding]; other site 315730013507 metal binding site [ion binding]; metal-binding site 315730013508 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 315730013509 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 315730013510 multifunctional aminopeptidase A; Provisional; Region: PRK00913 315730013511 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 315730013512 interface (dimer of trimers) [polypeptide binding]; other site 315730013513 Substrate-binding/catalytic site; other site 315730013514 Zn-binding sites [ion binding]; other site 315730013515 3D domain; Region: 3D; cl01439 315730013516 Putative membrane protein; Region: YuiB; pfam14068 315730013517 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 315730013518 nudix motif; other site 315730013519 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 315730013520 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315730013521 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 315730013522 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730013523 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 315730013524 H+ Antiporter protein; Region: 2A0121; TIGR00900 315730013525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730013526 putative substrate translocation pore; other site 315730013527 Helix-turn-helix domains; Region: HTH; cl00088 315730013528 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 315730013529 Protein of unknown function (DUF523); Region: DUF523; cl00733 315730013530 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 315730013531 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 315730013532 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 315730013533 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 315730013534 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 315730013535 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 315730013536 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 315730013537 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315730013538 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 315730013539 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730013540 Walker A/P-loop; other site 315730013541 ATP binding site [chemical binding]; other site 315730013542 Q-loop/lid; other site 315730013543 ABC transporter signature motif; other site 315730013544 Walker B; other site 315730013545 D-loop; other site 315730013546 H-loop/switch region; other site 315730013547 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 315730013548 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 315730013549 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 315730013550 PhnA protein; Region: PhnA; pfam03831 315730013551 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 315730013552 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 315730013553 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 315730013554 CAAX protease self-immunity; Region: Abi; cl00558 315730013555 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 315730013556 Protein of unknown function (DUF1462); Region: DUF1462; cl11552 315730013557 NifU-like domain; Region: NifU; cl00484 315730013558 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 315730013559 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 315730013560 tetramer interfaces [polypeptide binding]; other site 315730013561 binuclear metal-binding site [ion binding]; other site 315730013562 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730013563 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 315730013564 FtsX-like permease family; Region: FtsX; cl15850 315730013565 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 315730013566 FtsX-like permease family; Region: FtsX; cl15850 315730013567 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730013568 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 315730013569 Walker A/P-loop; other site 315730013570 ATP binding site [chemical binding]; other site 315730013571 Q-loop/lid; other site 315730013572 ABC transporter signature motif; other site 315730013573 Walker B; other site 315730013574 D-loop; other site 315730013575 H-loop/switch region; other site 315730013576 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 315730013577 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 315730013578 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730013579 active site 315730013580 motif I; other site 315730013581 motif II; other site 315730013582 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730013583 Predicted transcriptional regulator [Transcription]; Region: COG2345 315730013584 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730013585 putative DNA binding site [nucleotide binding]; other site 315730013586 putative Zn2+ binding site [ion binding]; other site 315730013587 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 315730013588 Protein of unknown function DUF86; Region: DUF86; cl01031 315730013589 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 315730013590 putative active site [active] 315730013591 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 315730013592 Transposase IS200 like; Region: Y1_Tnp; cl00848 315730013593 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 315730013594 Probable transposase; Region: OrfB_IS605; pfam01385 315730013595 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 315730013596 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 315730013597 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 315730013598 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315730013599 RNA binding surface [nucleotide binding]; other site 315730013600 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730013601 Coenzyme A binding pocket [chemical binding]; other site 315730013602 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 315730013603 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 315730013604 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 315730013605 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 315730013606 DNA binding residues [nucleotide binding] 315730013607 dimer interface [polypeptide binding]; other site 315730013608 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 315730013609 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 315730013610 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 315730013611 catalytic core [active] 315730013612 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 315730013613 putative deacylase active site [active] 315730013614 lipoyl synthase; Provisional; Region: PRK05481 315730013615 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315730013616 FeS/SAM binding site; other site 315730013617 Peptidase family M23; Region: Peptidase_M23; pfam01551 315730013618 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 315730013619 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 315730013620 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 315730013621 active site 315730013622 metal binding site [ion binding]; metal-binding site 315730013623 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 315730013624 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 315730013625 FeS assembly protein SufB; Region: sufB; TIGR01980 315730013626 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 315730013627 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 315730013628 trimerization site [polypeptide binding]; other site 315730013629 active site 315730013630 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 315730013631 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 315730013632 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 315730013633 catalytic residue [active] 315730013634 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 315730013635 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 315730013636 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 315730013637 FeS assembly ATPase SufC; Region: sufC; TIGR01978 315730013638 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 315730013639 Walker A/P-loop; other site 315730013640 ATP binding site [chemical binding]; other site 315730013641 Q-loop/lid; other site 315730013642 ABC transporter signature motif; other site 315730013643 Walker B; other site 315730013644 D-loop; other site 315730013645 H-loop/switch region; other site 315730013646 NMT1-like family; Region: NMT1_2; cl15260 315730013647 NMT1-like family; Region: NMT1_2; cl15260 315730013648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 315730013649 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 315730013650 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 315730013651 Walker A/P-loop; other site 315730013652 ATP binding site [chemical binding]; other site 315730013653 Q-loop/lid; other site 315730013654 ABC transporter signature motif; other site 315730013655 Walker B; other site 315730013656 D-loop; other site 315730013657 H-loop/switch region; other site 315730013658 NIL domain; Region: NIL; cl09633 315730013659 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 315730013660 catalytic residues [active] 315730013661 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 315730013662 putative active site [active] 315730013663 putative metal binding site [ion binding]; other site 315730013664 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 315730013665 lipoyl attachment site [posttranslational modification]; other site 315730013666 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 315730013667 ArsC family; Region: ArsC; pfam03960 315730013668 putative ArsC-like catalytic residues; other site 315730013669 putative TRX-like catalytic residues [active] 315730013670 Protein of unknown function (DUF3937); Region: DUF3937; pfam13073 315730013671 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 315730013672 Proteins of 100 residues with WXG; Region: WXG100; cl02005 315730013673 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 315730013674 active site 315730013675 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 315730013676 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 315730013677 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 315730013678 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 315730013679 tetramer (dimer of dimers) interface [polypeptide binding]; other site 315730013680 NAD binding site [chemical binding]; other site 315730013681 dimer interface [polypeptide binding]; other site 315730013682 substrate binding site [chemical binding]; other site 315730013683 Coat F domain; Region: Coat_F; cl15836 315730013684 CAAX protease self-immunity; Region: Abi; cl00558 315730013685 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730013686 WHG domain; Region: WHG; pfam13305 315730013687 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 315730013688 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315730013689 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 315730013690 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 315730013691 active site 315730013692 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 315730013693 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 315730013694 dimer interface [polypeptide binding]; other site 315730013695 active site 315730013696 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 315730013697 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730013698 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 315730013699 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 315730013700 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 315730013701 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 315730013702 substrate binding site [chemical binding]; other site 315730013703 oxyanion hole (OAH) forming residues; other site 315730013704 YuzL-like protein; Region: YuzL; pfam14115 315730013705 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 315730013706 Proline dehydrogenase; Region: Pro_dh; cl03282 315730013707 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 315730013708 Domain of unknown function DUF77; Region: DUF77; cl00307 315730013709 Cache domain; Region: Cache_1; pfam02743 315730013710 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730013711 dimerization interface [polypeptide binding]; other site 315730013712 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315730013713 dimer interface [polypeptide binding]; other site 315730013714 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315730013715 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315730013716 dimer interface [polypeptide binding]; other site 315730013717 putative CheW interface [polypeptide binding]; other site 315730013718 Helix-turn-helix domains; Region: HTH; cl00088 315730013719 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 315730013720 C-terminal domain interface [polypeptide binding]; other site 315730013721 sugar binding site [chemical binding]; other site 315730013722 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 315730013723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730013724 putative substrate translocation pore; other site 315730013725 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 315730013726 Spore germination protein; Region: Spore_permease; cl15802 315730013727 MAEBL; Provisional; Region: PTZ00121 315730013728 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 315730013729 Uncharacterized conserved protein [Function unknown]; Region: COG1284 315730013730 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 315730013731 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 315730013732 Protein of unknown function (DUF3938); Region: DUF3938; cl07999 315730013733 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 315730013734 active site 315730013735 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 315730013736 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730013737 non-specific DNA binding site [nucleotide binding]; other site 315730013738 salt bridge; other site 315730013739 sequence-specific DNA binding site [nucleotide binding]; other site 315730013740 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 315730013741 Protein of unknown function (DUF3978); Region: DUF3978; pfam13123 315730013742 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 315730013743 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730013744 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730013745 active site 315730013746 phosphorylation site [posttranslational modification] 315730013747 intermolecular recognition site; other site 315730013748 dimerization interface [polypeptide binding]; other site 315730013749 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730013750 DNA binding site [nucleotide binding] 315730013751 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730013752 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730013753 dimer interface [polypeptide binding]; other site 315730013754 phosphorylation site [posttranslational modification] 315730013755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730013756 ATP binding site [chemical binding]; other site 315730013757 Mg2+ binding site [ion binding]; other site 315730013758 G-X-G motif; other site 315730013759 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 315730013760 EamA-like transporter family; Region: EamA; cl01037 315730013761 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 315730013762 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 315730013763 active site 315730013764 HIGH motif; other site 315730013765 KMSKS motif; other site 315730013766 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 315730013767 tRNA binding surface [nucleotide binding]; other site 315730013768 anticodon binding site; other site 315730013769 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730013770 S-adenosylmethionine binding site [chemical binding]; other site 315730013771 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730013772 dimerization interface [polypeptide binding]; other site 315730013773 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315730013774 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315730013775 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315730013776 dimer interface [polypeptide binding]; other site 315730013777 putative CheW interface [polypeptide binding]; other site 315730013778 CHASE3 domain; Region: CHASE3; cl05000 315730013779 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730013780 dimerization interface [polypeptide binding]; other site 315730013781 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315730013782 dimer interface [polypeptide binding]; other site 315730013783 putative CheW interface [polypeptide binding]; other site 315730013784 Domain of unknown function DUF59; Region: DUF59; cl00941 315730013785 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 315730013786 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 315730013787 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 315730013788 active site 315730013789 Zn binding site [ion binding]; other site 315730013790 Cupin domain; Region: Cupin_2; cl09118 315730013791 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 315730013792 Helix-turn-helix domains; Region: HTH; cl00088 315730013793 Protein of unknown function (DUF3920); Region: DUF3920; pfam13058 315730013794 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 315730013795 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 315730013796 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 315730013797 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 315730013798 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 315730013799 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 315730013800 Ferritin-like domain; Region: Ferritin; pfam00210 315730013801 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 315730013802 dimerization interface [polypeptide binding]; other site 315730013803 DPS ferroxidase diiron center [ion binding]; other site 315730013804 ion pore; other site 315730013805 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 315730013806 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 315730013807 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 315730013808 Ferritin-like domain; Region: Ferritin; pfam00210 315730013809 ferroxidase diiron center [ion binding]; other site 315730013810 Predicted membrane protein [Function unknown]; Region: COG2311 315730013811 Protein of unknown function (DUF418); Region: DUF418; cl12135 315730013812 Protein of unknown function (DUF418); Region: DUF418; cl12135 315730013813 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 315730013814 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 315730013815 Nucleoside recognition; Region: Gate; cl00486 315730013816 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 315730013817 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 315730013818 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 315730013819 Nucleoside recognition; Region: Gate; cl00486 315730013820 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 315730013821 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 315730013822 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 315730013823 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 315730013824 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 315730013825 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 315730013826 NADH(P)-binding; Region: NAD_binding_10; pfam13460 315730013827 NAD binding site [chemical binding]; other site 315730013828 substrate binding site [chemical binding]; other site 315730013829 putative active site [active] 315730013830 Peptidase M60-like family; Region: M60-like; pfam13402 315730013831 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 315730013832 Coenzyme A binding pocket [chemical binding]; other site 315730013833 TMPIT-like protein; Region: TMPIT; pfam07851 315730013834 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 315730013835 TQXA domain; Region: TQXA_dom; TIGR03934 315730013836 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 315730013837 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 315730013838 active site 315730013839 catalytic tetrad [active] 315730013840 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 315730013841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730013842 putative substrate translocation pore; other site 315730013843 Helix-turn-helix domains; Region: HTH; cl00088 315730013844 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 315730013845 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 315730013846 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315730013847 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 315730013848 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 315730013849 active site 315730013850 HIGH motif; other site 315730013851 dimer interface [polypeptide binding]; other site 315730013852 KMSKS motif; other site 315730013853 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 315730013854 RNA binding surface [nucleotide binding]; other site 315730013855 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK12436 315730013856 FAD binding domain; Region: FAD_binding_4; pfam01565 315730013857 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 315730013858 SET domain; Region: SET; cl02566 315730013859 Domain of unknown function (DUF4077); Region: DUF4077; pfam13295 315730013860 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 315730013861 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315730013862 dimer interface [polypeptide binding]; other site 315730013863 putative CheW interface [polypeptide binding]; other site 315730013864 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 315730013865 putative phosphate binding site [ion binding]; other site 315730013866 CrcB-like protein; Region: CRCB; cl09114 315730013867 CrcB-like protein; Region: CRCB; cl09114 315730013868 Protein of unknown function (DUF3947); Region: DUF3947; pfam13135 315730013869 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 315730013870 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 315730013871 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730013872 Phosphate-starvation-inducible E; Region: PsiE; cl01264 315730013873 Helix-turn-helix domains; Region: HTH; cl00088 315730013874 Helix-turn-helix domains; Region: HTH; cl00088 315730013875 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 315730013876 active site clefts [active] 315730013877 zinc binding site [ion binding]; other site 315730013878 dimer interface [polypeptide binding]; other site 315730013879 cyanate hydratase; Validated; Region: PRK02866 315730013880 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 315730013881 oligomer interface [polypeptide binding]; other site 315730013882 active site 315730013883 putative uracil/xanthine transporter; Provisional; Region: PRK11412 315730013884 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 315730013885 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 315730013886 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 315730013887 Walker A/P-loop; other site 315730013888 ATP binding site [chemical binding]; other site 315730013889 Q-loop/lid; other site 315730013890 ABC transporter signature motif; other site 315730013891 Walker B; other site 315730013892 D-loop; other site 315730013893 H-loop/switch region; other site 315730013894 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315730013895 ABC-ATPase subunit interface; other site 315730013896 dimer interface [polypeptide binding]; other site 315730013897 putative PBP binding regions; other site 315730013898 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315730013899 ABC-ATPase subunit interface; other site 315730013900 dimer interface [polypeptide binding]; other site 315730013901 putative PBP binding regions; other site 315730013902 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 315730013903 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 315730013904 intersubunit interface [polypeptide binding]; other site 315730013905 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730013906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730013907 active site 315730013908 phosphorylation site [posttranslational modification] 315730013909 intermolecular recognition site; other site 315730013910 dimerization interface [polypeptide binding]; other site 315730013911 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730013912 DNA binding site [nucleotide binding] 315730013913 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 315730013914 SmpB-tmRNA interface; other site 315730013915 ribonuclease R; Region: RNase_R; TIGR02063 315730013916 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 315730013917 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 315730013918 RNB domain; Region: RNB; pfam00773 315730013919 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 315730013920 RNA binding site [nucleotide binding]; other site 315730013921 Esterase/lipase [General function prediction only]; Region: COG1647 315730013922 LrgB-like family; Region: LrgB; cl00596 315730013923 LrgA family; Region: LrgA; cl00608 315730013924 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 315730013925 active site 315730013926 enolase; Provisional; Region: eno; PRK00077 315730013927 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 315730013928 dimer interface [polypeptide binding]; other site 315730013929 metal binding site [ion binding]; metal-binding site 315730013930 substrate binding pocket [chemical binding]; other site 315730013931 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 315730013932 Sulfatase; Region: Sulfatase; cl10460 315730013933 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 315730013934 substrate binding site [chemical binding]; other site 315730013935 dimer interface [polypeptide binding]; other site 315730013936 catalytic triad [active] 315730013937 Phosphoglycerate kinase; Region: PGK; pfam00162 315730013938 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 315730013939 substrate binding site [chemical binding]; other site 315730013940 hinge regions; other site 315730013941 ADP binding site [chemical binding]; other site 315730013942 catalytic site [active] 315730013943 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 315730013944 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730013945 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 315730013946 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 315730013947 Predicted transcriptional regulator [Transcription]; Region: COG3388 315730013948 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 315730013949 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 315730013950 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 315730013951 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 315730013952 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 315730013953 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 315730013954 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 315730013955 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 315730013956 SpoVA protein; Region: SpoVA; cl04298 315730013957 stage V sporulation protein AD; Provisional; Region: PRK12404 315730013958 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 315730013959 SpoVA protein; Region: SpoVA; cl04298 315730013960 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 315730013961 Protein of unknown function (DUF421); Region: DUF421; cl00990 315730013962 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 315730013963 Clp protease; Region: CLP_protease; pfam00574 315730013964 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 315730013965 oligomer interface [polypeptide binding]; other site 315730013966 active site residues [active] 315730013967 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 315730013968 dimerization domain swap beta strand [polypeptide binding]; other site 315730013969 regulatory protein interface [polypeptide binding]; other site 315730013970 active site 315730013971 regulatory phosphorylation site [posttranslational modification]; other site 315730013972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 315730013973 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 315730013974 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 315730013975 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 315730013976 phosphate binding site [ion binding]; other site 315730013977 putative substrate binding pocket [chemical binding]; other site 315730013978 dimer interface [polypeptide binding]; other site 315730013979 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 315730013980 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 315730013981 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 315730013982 putative active site [active] 315730013983 nucleotide binding site [chemical binding]; other site 315730013984 nudix motif; other site 315730013985 putative metal binding site [ion binding]; other site 315730013986 Domain of unknown function (DUF368); Region: DUF368; cl00893 315730013987 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 315730013988 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730013989 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 315730013990 TPR repeat; Region: TPR_11; pfam13414 315730013991 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730013992 binding surface 315730013993 TPR motif; other site 315730013994 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315730013995 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 315730013996 binding surface 315730013997 Tetratricopeptide repeat; Region: TPR_16; pfam13432 315730013998 TPR motif; other site 315730013999 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 315730014000 trimer interface [polypeptide binding]; other site 315730014001 active site 315730014002 substrate binding site [chemical binding]; other site 315730014003 CoA binding site [chemical binding]; other site 315730014004 pyrophosphatase PpaX; Provisional; Region: PRK13288 315730014005 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730014006 active site 315730014007 motif I; other site 315730014008 motif II; other site 315730014009 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 315730014010 HPr kinase/phosphorylase; Provisional; Region: PRK05428 315730014011 DRTGG domain; Region: DRTGG; cl12147 315730014012 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 315730014013 Hpr binding site; other site 315730014014 active site 315730014015 homohexamer subunit interaction site [polypeptide binding]; other site 315730014016 Membrane protein of unknown function; Region: DUF360; cl00850 315730014017 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 315730014018 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 315730014019 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 315730014020 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 315730014021 excinuclease ABC subunit B; Provisional; Region: PRK05298 315730014022 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315730014023 ATP binding site [chemical binding]; other site 315730014024 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315730014025 nucleotide binding region [chemical binding]; other site 315730014026 ATP-binding site [chemical binding]; other site 315730014027 Ultra-violet resistance protein B; Region: UvrB; pfam12344 315730014028 Domain of unknown function (DUF4362); Region: DUF4362; pfam14275 315730014029 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 315730014030 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315730014031 DNA binding residues [nucleotide binding] 315730014032 dimer interface [polypeptide binding]; other site 315730014033 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 315730014034 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730014035 non-specific DNA binding site [nucleotide binding]; other site 315730014036 salt bridge; other site 315730014037 sequence-specific DNA binding site [nucleotide binding]; other site 315730014038 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 315730014039 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315730014040 Helix-turn-helix domains; Region: HTH; cl00088 315730014041 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 315730014042 putative dimerization interface [polypeptide binding]; other site 315730014043 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 315730014044 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 315730014045 DNA binding residues [nucleotide binding] 315730014046 putative dimer interface [polypeptide binding]; other site 315730014047 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 315730014048 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 315730014049 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 315730014050 ABC transporter; Region: ABC_tran_2; pfam12848 315730014051 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 315730014052 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 315730014053 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 315730014054 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 315730014055 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 315730014056 Walker A/P-loop; other site 315730014057 ATP binding site [chemical binding]; other site 315730014058 Q-loop/lid; other site 315730014059 ABC transporter signature motif; other site 315730014060 Walker B; other site 315730014061 D-loop; other site 315730014062 H-loop/switch region; other site 315730014063 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 315730014064 protein binding site [polypeptide binding]; other site 315730014065 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 315730014066 C-terminal peptidase (prc); Region: prc; TIGR00225 315730014067 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 315730014068 protein binding site [polypeptide binding]; other site 315730014069 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 315730014070 Catalytic dyad [active] 315730014071 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 315730014072 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 315730014073 FtsX-like permease family; Region: FtsX; cl15850 315730014074 FtsX-like permease family; Region: FtsX; cl15850 315730014075 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 315730014076 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730014077 Walker A/P-loop; other site 315730014078 ATP binding site [chemical binding]; other site 315730014079 Q-loop/lid; other site 315730014080 ABC transporter signature motif; other site 315730014081 Walker B; other site 315730014082 D-loop; other site 315730014083 H-loop/switch region; other site 315730014084 Cytochrome c; Region: Cytochrom_C; cl11414 315730014085 peptide chain release factor 2; Provisional; Region: PRK06746 315730014086 RF-1 domain; Region: RF-1; cl02875 315730014087 RF-1 domain; Region: RF-1; cl02875 315730014088 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 315730014089 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 315730014090 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730014091 SEC-C motif; Region: SEC-C; pfam02810 315730014092 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 315730014093 active site 315730014094 metal binding site [ion binding]; metal-binding site 315730014095 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 315730014096 30S subunit binding site; other site 315730014097 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 315730014098 DNA-binding site [nucleotide binding]; DNA binding site 315730014099 RNA-binding motif; other site 315730014100 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 315730014101 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315730014102 active site 315730014103 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 315730014104 DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers; Region: NR_DBD_like; cl02596 315730014105 zinc binding site [ion binding]; other site 315730014106 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315730014107 ATP binding site [chemical binding]; other site 315730014108 putative Mg++ binding site [ion binding]; other site 315730014109 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315730014110 nucleotide binding region [chemical binding]; other site 315730014111 ATP-binding site [chemical binding]; other site 315730014112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 315730014113 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 315730014114 NlpC/P60 family; Region: NLPC_P60; cl11438 315730014115 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 315730014116 dimerization interface [polypeptide binding]; other site 315730014117 putative DNA binding site [nucleotide binding]; other site 315730014118 putative Zn2+ binding site [ion binding]; other site 315730014119 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 315730014120 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 315730014121 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 315730014122 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 315730014123 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 315730014124 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 315730014125 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 315730014126 active site 315730014127 homodimer interface [polypeptide binding]; other site 315730014128 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 315730014129 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730014130 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 315730014131 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730014132 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 315730014133 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 315730014134 Mg++ binding site [ion binding]; other site 315730014135 putative catalytic motif [active] 315730014136 substrate binding site [chemical binding]; other site 315730014137 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 315730014138 NodB motif; other site 315730014139 active site 315730014140 catalytic site [active] 315730014141 Zn binding site [ion binding]; other site 315730014142 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 315730014143 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 315730014144 Walker A motif; other site 315730014145 ATP binding site [chemical binding]; other site 315730014146 Walker B motif; other site 315730014147 arginine finger; other site 315730014148 Transcriptional antiterminator [Transcription]; Region: COG3933 315730014149 PRD domain; Region: PRD; cl15445 315730014150 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 315730014151 active pocket/dimerization site; other site 315730014152 active site 315730014153 phosphorylation site [posttranslational modification] 315730014154 PRD domain; Region: PRD; cl15445 315730014155 CHRD domain; Region: CHRD; cl06473 315730014156 Chromate transporter; Region: Chromate_transp; pfam02417 315730014157 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 315730014158 Chromate transporter; Region: Chromate_transp; pfam02417 315730014159 YdjC-like protein; Region: YdjC; cl01344 315730014160 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 315730014161 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 315730014162 NAD binding site [chemical binding]; other site 315730014163 sugar binding site [chemical binding]; other site 315730014164 divalent metal binding site [ion binding]; other site 315730014165 tetramer (dimer of dimers) interface [polypeptide binding]; other site 315730014166 dimer interface [polypeptide binding]; other site 315730014167 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 315730014168 active site 315730014169 methionine cluster; other site 315730014170 phosphorylation site [posttranslational modification] 315730014171 metal binding site [ion binding]; metal-binding site 315730014172 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 315730014173 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 315730014174 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 315730014175 active site 315730014176 P-loop; other site 315730014177 phosphorylation site [posttranslational modification] 315730014178 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 315730014179 methionine cluster; other site 315730014180 active site 315730014181 phosphorylation site [posttranslational modification] 315730014182 metal binding site [ion binding]; metal-binding site 315730014183 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 315730014184 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 315730014185 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 315730014186 active site 315730014187 P-loop; other site 315730014188 phosphorylation site [posttranslational modification] 315730014189 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 315730014190 Acyltransferase family; Region: Acyl_transf_3; pfam01757 315730014191 OpgC protein; Region: OpgC_C; cl00792 315730014192 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 315730014193 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 315730014194 Predicted membrane protein [Function unknown]; Region: COG1511 315730014195 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 315730014196 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 315730014197 Transcriptional regulator [Transcription]; Region: LysR; COG0583 315730014198 Helix-turn-helix domains; Region: HTH; cl00088 315730014199 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 315730014200 putative dimerization interface [polypeptide binding]; other site 315730014201 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 315730014202 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 315730014203 arsenical pump membrane protein; Provisional; Region: PRK15445 315730014204 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 315730014205 transmembrane helices; other site 315730014206 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 315730014207 ThiC-associated domain; Region: ThiC-associated; pfam13667 315730014208 ThiC family; Region: ThiC; cl08031 315730014209 L-lactate permease; Region: Lactate_perm; cl00701 315730014210 glycolate transporter; Provisional; Region: PRK09695 315730014211 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; cl01017 315730014212 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 315730014213 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 315730014214 Sulfatase; Region: Sulfatase; cl10460 315730014215 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 315730014216 homodimer interface [polypeptide binding]; other site 315730014217 substrate-cofactor binding pocket; other site 315730014218 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730014219 catalytic residue [active] 315730014220 Bacterial SH3 domain; Region: SH3_3; cl02551 315730014221 Bacterial SH3 domain; Region: SH3_3; cl02551 315730014222 Bacterial SH3 domain; Region: SH3_3; cl02551 315730014223 Bacterial SH3 domain; Region: SH3_3; cl02551 315730014224 Bacterial SH3 domain; Region: SH3_3; cl02551 315730014225 NlpC/P60 family; Region: NLPC_P60; cl11438 315730014226 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 315730014227 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 315730014228 Nucleoside recognition; Region: Gate; cl00486 315730014229 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 315730014230 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 315730014231 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 315730014232 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 315730014233 DXD motif; other site 315730014234 BCCT family transporter; Region: BCCT; cl00569 315730014235 Bacterial SH3 domain; Region: SH3_3; cl02551 315730014236 Bacterial SH3 domain; Region: SH3_3; cl02551 315730014237 3D domain; Region: 3D; cl01439 315730014238 Protein of unknown function (DUF3910); Region: DUF3910; pfam13049 315730014239 Predicted membrane protein [Function unknown]; Region: COG4640 315730014240 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 315730014241 Double zinc ribbon; Region: DZR; pfam12773 315730014242 Double zinc ribbon; Region: DZR; pfam12773 315730014243 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 315730014244 SNF2 Helicase protein; Region: DUF3670; pfam12419 315730014245 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 315730014246 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 315730014247 ATP binding site [chemical binding]; other site 315730014248 putative Mg++ binding site [ion binding]; other site 315730014249 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315730014250 nucleotide binding region [chemical binding]; other site 315730014251 ATP-binding site [chemical binding]; other site 315730014252 VanZ like family; Region: VanZ; cl01971 315730014253 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 315730014254 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 315730014255 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 315730014256 ComK protein; Region: ComK; cl11560 315730014257 RNA polymerase factor sigma-70; Validated; Region: PRK06759 315730014258 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 315730014259 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 315730014260 DNA binding residues [nucleotide binding] 315730014261 Yip1 domain; Region: Yip1; cl12048 315730014262 Yip1 domain; Region: Yip1; cl12048 315730014263 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 315730014264 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 315730014265 FtsX-like permease family; Region: FtsX; cl15850 315730014266 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 315730014267 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 315730014268 Walker A/P-loop; other site 315730014269 ATP binding site [chemical binding]; other site 315730014270 Q-loop/lid; other site 315730014271 ABC transporter signature motif; other site 315730014272 Walker B; other site 315730014273 D-loop; other site 315730014274 H-loop/switch region; other site 315730014275 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 315730014276 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 315730014277 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 315730014278 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730014279 putative substrate translocation pore; other site 315730014280 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 315730014281 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 315730014282 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 315730014283 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 315730014284 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730014285 dimerization interface [polypeptide binding]; other site 315730014286 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730014287 dimer interface [polypeptide binding]; other site 315730014288 phosphorylation site [posttranslational modification] 315730014289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730014290 ATP binding site [chemical binding]; other site 315730014291 Mg2+ binding site [ion binding]; other site 315730014292 G-X-G motif; other site 315730014293 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730014294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730014295 active site 315730014296 phosphorylation site [posttranslational modification] 315730014297 intermolecular recognition site; other site 315730014298 dimerization interface [polypeptide binding]; other site 315730014299 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730014300 DNA binding site [nucleotide binding] 315730014301 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 315730014302 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 315730014303 NAD binding site [chemical binding]; other site 315730014304 homodimer interface [polypeptide binding]; other site 315730014305 active site 315730014306 substrate binding site [chemical binding]; other site 315730014307 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 315730014308 active site 315730014309 catalytic triad [active] 315730014310 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 315730014311 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 315730014312 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730014313 UDP-galactopyranose mutase; Region: GLF; pfam03275 315730014314 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 315730014315 MatE; Region: MatE; cl10513 315730014316 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315730014317 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 315730014318 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315730014319 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 315730014320 ATP-grasp domain; Region: ATP-grasp_4; cl03087 315730014321 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 315730014322 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 315730014323 putative NAD(P) binding site [chemical binding]; other site 315730014324 active site 315730014325 putative substrate binding site [chemical binding]; other site 315730014326 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 315730014327 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730014328 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 315730014329 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730014330 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 315730014331 putative ADP-binding pocket [chemical binding]; other site 315730014332 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 315730014333 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730014334 NAD(P) binding site [chemical binding]; other site 315730014335 active site 315730014336 Bacterial sugar transferase; Region: Bac_transf; cl00939 315730014337 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 315730014338 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730014339 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 315730014340 NAD(P) binding site [chemical binding]; other site 315730014341 homodimer interface [polypeptide binding]; other site 315730014342 substrate binding site [chemical binding]; other site 315730014343 active site 315730014344 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 315730014345 active site 315730014346 tetramer interface; other site 315730014347 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 315730014348 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 315730014349 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730014350 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 315730014351 Chain length determinant protein; Region: Wzz; cl15801 315730014352 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 315730014353 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730014354 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 315730014355 rod shape-determining protein Mbl; Provisional; Region: PRK13928 315730014356 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 315730014357 ATP binding site [chemical binding]; other site 315730014358 profilin binding site; other site 315730014359 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 315730014360 Peptidase family M23; Region: Peptidase_M23; pfam01551 315730014361 ABC-2 type transporter; Region: ABC2_membrane; cl11417 315730014362 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315730014363 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730014364 Walker A/P-loop; other site 315730014365 ATP binding site [chemical binding]; other site 315730014366 Q-loop/lid; other site 315730014367 ABC transporter signature motif; other site 315730014368 Walker B; other site 315730014369 D-loop; other site 315730014370 H-loop/switch region; other site 315730014371 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 315730014372 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730014373 Walker A/P-loop; other site 315730014374 ATP binding site [chemical binding]; other site 315730014375 Q-loop/lid; other site 315730014376 ABC transporter signature motif; other site 315730014377 Walker B; other site 315730014378 D-loop; other site 315730014379 H-loop/switch region; other site 315730014380 LytTr DNA-binding domain; Region: LytTR; cl04498 315730014381 stage II sporulation protein D; Region: spore_II_D; TIGR02870 315730014382 Stage II sporulation protein; Region: SpoIID; pfam08486 315730014383 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 315730014384 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 315730014385 hinge; other site 315730014386 active site 315730014387 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 315730014388 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 315730014389 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 315730014390 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 315730014391 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 315730014392 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 315730014393 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 315730014394 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 315730014395 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 315730014396 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 315730014397 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 315730014398 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 315730014399 4Fe-4S binding domain; Region: Fer4; cl02805 315730014400 4Fe-4S binding domain; Region: Fer4; cl02805 315730014401 NADH dehydrogenase; Region: NADHdh; cl00469 315730014402 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 315730014403 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 315730014404 NADH dehydrogenase subunit C; Validated; Region: PRK07735 315730014405 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 315730014406 NADH dehydrogenase subunit B; Validated; Region: PRK06411 315730014407 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 315730014408 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 315730014409 Domain of unknown function (DUF4084); Region: DUF4084; pfam13321 315730014410 PAS domain S-box; Region: sensory_box; TIGR00229 315730014411 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 315730014412 putative active site [active] 315730014413 heme pocket [chemical binding]; other site 315730014414 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 315730014415 metal binding site [ion binding]; metal-binding site 315730014416 active site 315730014417 I-site; other site 315730014418 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 315730014419 Protein of unknown function (DUF975); Region: DUF975; cl10504 315730014420 Protein of unknown function (DUF975); Region: DUF975; cl10504 315730014421 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 315730014422 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 315730014423 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 315730014424 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 315730014425 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 315730014426 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 315730014427 alpha subunit interaction interface [polypeptide binding]; other site 315730014428 Walker A motif; other site 315730014429 ATP binding site [chemical binding]; other site 315730014430 Walker B motif; other site 315730014431 inhibitor binding site; inhibition site 315730014432 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 315730014433 ATP synthase; Region: ATP-synt; cl00365 315730014434 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 315730014435 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 315730014436 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 315730014437 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 315730014438 beta subunit interaction interface [polypeptide binding]; other site 315730014439 Walker A motif; other site 315730014440 ATP binding site [chemical binding]; other site 315730014441 Walker B motif; other site 315730014442 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 315730014443 Plant ATP synthase F0; Region: YMF19; cl07975 315730014444 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 315730014445 Plant ATP synthase F0; Region: YMF19; cl07975 315730014446 ATP synthase subunit C; Region: ATP-synt_C; cl00466 315730014447 ATP synthase A chain; Region: ATP-synt_A; cl00413 315730014448 ATP synthase I chain; Region: ATP_synt_I; cl09170 315730014449 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 315730014450 Protein of unknown function (DUF4024); Region: DUF4024; pfam13216 315730014451 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 315730014452 active site 315730014453 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 315730014454 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 315730014455 dimer interface [polypeptide binding]; other site 315730014456 glycine-pyridoxal phosphate binding site [chemical binding]; other site 315730014457 active site 315730014458 folate binding site [chemical binding]; other site 315730014459 Protein of unknown function (DUF436); Region: DUF436; cl01860 315730014460 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 315730014461 Low molecular weight phosphatase family; Region: LMWPc; cd00115 315730014462 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 315730014463 active site 315730014464 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 315730014465 HPr interaction site; other site 315730014466 glycerol kinase (GK) interaction site [polypeptide binding]; other site 315730014467 active site 315730014468 phosphorylation site [posttranslational modification] 315730014469 DoxX; Region: DoxX; cl00976 315730014470 Flavin Reductases; Region: FlaRed; cl00801 315730014471 Protein of unknown function (DUF3935); Region: DUF3935; pfam13071 315730014472 Domain of unknown function DUF; Region: DUF204; pfam02659 315730014473 Domain of unknown function DUF; Region: DUF204; pfam02659 315730014474 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 315730014475 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 315730014476 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 315730014477 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775 315730014478 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 315730014479 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730014480 S-adenosylmethionine binding site [chemical binding]; other site 315730014481 peptide chain release factor 1; Validated; Region: prfA; PRK00591 315730014482 RF-1 domain; Region: RF-1; cl02875 315730014483 RF-1 domain; Region: RF-1; cl02875 315730014484 thymidine kinase; Provisional; Region: PRK04296 315730014485 LabA_like proteins; Region: LabA_like/DUF88; cl10034 315730014486 putative metal binding site [ion binding]; other site 315730014487 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 315730014488 transcription termination factor Rho; Provisional; Region: rho; PRK09376 315730014489 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 315730014490 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 315730014491 RNA binding site [nucleotide binding]; other site 315730014492 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 315730014493 multimer interface [polypeptide binding]; other site 315730014494 Walker A motif; other site 315730014495 ATP binding site [chemical binding]; other site 315730014496 Walker B motif; other site 315730014497 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 315730014498 putative active site [active] 315730014499 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 315730014500 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 315730014501 hinge; other site 315730014502 active site 315730014503 hypothetical protein; Provisional; Region: PRK08185 315730014504 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 315730014505 intersubunit interface [polypeptide binding]; other site 315730014506 active site 315730014507 zinc binding site [ion binding]; other site 315730014508 Na+ binding site [ion binding]; other site 315730014509 Response regulator receiver domain; Region: Response_reg; pfam00072 315730014510 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730014511 active site 315730014512 phosphorylation site [posttranslational modification] 315730014513 intermolecular recognition site; other site 315730014514 dimerization interface [polypeptide binding]; other site 315730014515 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 315730014516 CTP synthetase; Validated; Region: pyrG; PRK05380 315730014517 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 315730014518 Catalytic site [active] 315730014519 active site 315730014520 UTP binding site [chemical binding]; other site 315730014521 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 315730014522 active site 315730014523 putative oxyanion hole; other site 315730014524 catalytic triad [active] 315730014525 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 315730014526 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730014527 Helix-turn-helix domains; Region: HTH; cl00088 315730014528 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 315730014529 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 315730014530 FAD binding site [chemical binding]; other site 315730014531 homotetramer interface [polypeptide binding]; other site 315730014532 substrate binding pocket [chemical binding]; other site 315730014533 catalytic base [active] 315730014534 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 315730014535 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 315730014536 FAD binding site [chemical binding]; other site 315730014537 homotetramer interface [polypeptide binding]; other site 315730014538 substrate binding pocket [chemical binding]; other site 315730014539 catalytic base [active] 315730014540 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 315730014541 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730014542 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 315730014543 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 315730014544 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 315730014545 dimer interface [polypeptide binding]; other site 315730014546 active site 315730014547 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 315730014548 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 315730014549 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 315730014550 Cysteine-rich domain; Region: CCG; pfam02754 315730014551 Cysteine-rich domain; Region: CCG; pfam02754 315730014552 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 315730014553 putative active site [active] 315730014554 catalytic site [active] 315730014555 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 315730014556 PLD-like domain; Region: PLDc_2; pfam13091 315730014557 putative active site [active] 315730014558 catalytic site [active] 315730014559 UV-endonuclease UvdE; Region: UvdE; cl10036 315730014560 Domain of unknown function (DUF4084); Region: DUF4084; pfam13321 315730014561 PAS domain S-box; Region: sensory_box; TIGR00229 315730014562 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 315730014563 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 315730014564 metal binding site [ion binding]; metal-binding site 315730014565 active site 315730014566 I-site; other site 315730014567 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 315730014568 Bacillus PapR protein; Region: Bacillus_PapR; pfam05968 315730014569 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 315730014570 non-specific DNA binding site [nucleotide binding]; other site 315730014571 salt bridge; other site 315730014572 sequence-specific DNA binding site [nucleotide binding]; other site 315730014573 Tetratricopeptide repeat; Region: TPR_12; pfam13424 315730014574 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 315730014575 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 315730014576 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 315730014577 active site 315730014578 Zn binding site [ion binding]; other site 315730014579 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 315730014580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730014581 active site 315730014582 phosphorylation site [posttranslational modification] 315730014583 intermolecular recognition site; other site 315730014584 dimerization interface [polypeptide binding]; other site 315730014585 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 315730014586 DNA binding residues [nucleotide binding] 315730014587 dimerization interface [polypeptide binding]; other site 315730014588 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 315730014589 CCC1-related family of proteins; Region: CCC1_like; cl00278 315730014590 Histidine kinase; Region: HisKA_3; pfam07730 315730014591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 315730014592 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 315730014593 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315730014594 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 315730014595 Walker A/P-loop; other site 315730014596 ATP binding site [chemical binding]; other site 315730014597 Q-loop/lid; other site 315730014598 ABC transporter signature motif; other site 315730014599 Walker B; other site 315730014600 D-loop; other site 315730014601 H-loop/switch region; other site 315730014602 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 315730014603 active site 315730014604 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 315730014605 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 315730014606 PA/protease or protease-like domain interface [polypeptide binding]; other site 315730014607 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 315730014608 metal binding site [ion binding]; metal-binding site 315730014609 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 315730014610 Collagen binding domain; Region: Collagen_bind; pfam05737 315730014611 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 315730014612 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cd00222 315730014613 domain interaction interfaces; other site 315730014614 putative Ca2+ binding sites [ion binding]; other site 315730014615 putative ligand binding motif; other site 315730014616 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cd00222 315730014617 domain interaction interfaces; other site 315730014618 putative Ca2+ binding sites [ion binding]; other site 315730014619 putative ligand binding motif; other site 315730014620 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cd00222 315730014621 putative Ca2+ binding sites [ion binding]; other site 315730014622 domain interaction interfaces; other site 315730014623 putative ligand binding motif; other site 315730014624 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cd00222 315730014625 putative Ca2+ binding sites [ion binding]; other site 315730014626 domain interaction interfaces; other site 315730014627 putative ligand binding motif; other site 315730014628 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cd00222 315730014629 putative Ca2+ binding sites [ion binding]; other site 315730014630 domain interaction interfaces; other site 315730014631 putative ligand binding motif; other site 315730014632 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cd00222 315730014633 putative Ca2+ binding sites [ion binding]; other site 315730014634 domain interaction interfaces; other site 315730014635 putative ligand binding motif; other site 315730014636 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cd00222 315730014637 putative Ca2+ binding sites [ion binding]; other site 315730014638 domain interaction interfaces; other site 315730014639 putative ligand binding motif; other site 315730014640 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cd00222 315730014641 putative Ca2+ binding sites [ion binding]; other site 315730014642 domain interaction interfaces; other site 315730014643 putative ligand binding motif; other site 315730014644 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cd00222 315730014645 putative Ca2+ binding sites [ion binding]; other site 315730014646 domain interaction interfaces; other site 315730014647 putative ligand binding motif; other site 315730014648 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cd00222 315730014649 putative Ca2+ binding sites [ion binding]; other site 315730014650 domain interaction interfaces; other site 315730014651 putative ligand binding motif; other site 315730014652 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cd00222 315730014653 putative Ca2+ binding sites [ion binding]; other site 315730014654 domain interaction interfaces; other site 315730014655 putative ligand binding motif; other site 315730014656 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 315730014657 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 315730014658 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 315730014659 active site 315730014660 HIGH motif; other site 315730014661 KMSK motif region; other site 315730014662 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 315730014663 tRNA binding surface [nucleotide binding]; other site 315730014664 anticodon binding site; other site 315730014665 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 315730014666 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 315730014667 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 315730014668 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 315730014669 Arginase family; Region: Arginase; cl00306 315730014670 spermidine synthase; Provisional; Region: PRK00811 315730014671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 315730014672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730014673 Major Facilitator Superfamily; Region: MFS_1; pfam07690 315730014674 putative substrate translocation pore; other site 315730014675 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 315730014676 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 315730014677 DNA binding residues [nucleotide binding] 315730014678 putative dimer interface [polypeptide binding]; other site 315730014679 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 315730014680 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 315730014681 active site 315730014682 catalytic site [active] 315730014683 metal binding site [ion binding]; metal-binding site 315730014684 dimer interface [polypeptide binding]; other site 315730014685 Transglycosylase; Region: Transgly; cl07896 315730014686 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 315730014687 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730014688 YwhD family; Region: YwhD; pfam08741 315730014689 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 315730014690 active site 315730014691 putative substrate binding region [chemical binding]; other site 315730014692 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 315730014693 active site 1 [active] 315730014694 dimer interface [polypeptide binding]; other site 315730014695 hexamer interface [polypeptide binding]; other site 315730014696 active site 2 [active] 315730014697 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 315730014698 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 315730014699 Zn2+ binding site [ion binding]; other site 315730014700 Mg2+ binding site [ion binding]; other site 315730014701 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 315730014702 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 315730014703 intersubunit interface [polypeptide binding]; other site 315730014704 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 315730014705 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 315730014706 Walker A/P-loop; other site 315730014707 ATP binding site [chemical binding]; other site 315730014708 Q-loop/lid; other site 315730014709 ABC transporter signature motif; other site 315730014710 Walker B; other site 315730014711 D-loop; other site 315730014712 H-loop/switch region; other site 315730014713 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 315730014714 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 315730014715 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315730014716 ABC-ATPase subunit interface; other site 315730014717 dimer interface [polypeptide binding]; other site 315730014718 putative PBP binding regions; other site 315730014719 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 315730014720 ABC-ATPase subunit interface; other site 315730014721 dimer interface [polypeptide binding]; other site 315730014722 putative PBP binding regions; other site 315730014723 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 315730014724 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 315730014725 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 315730014726 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 315730014727 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 315730014728 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 315730014729 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 315730014730 Chlorite dismutase; Region: Chlor_dismutase; cl01280 315730014731 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 315730014732 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 315730014733 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 315730014734 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 315730014735 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; cl09881 315730014736 Protein of unknown function (DUF423); Region: DUF423; cl01008 315730014737 Ion channel; Region: Ion_trans_2; cl11596 315730014738 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 315730014739 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730014740 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 315730014741 putative uracil/xanthine transporter; Provisional; Region: PRK11412 315730014742 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 315730014743 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730014744 motif II; other site 315730014745 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730014746 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 315730014747 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 315730014748 ligand binding site [chemical binding]; other site 315730014749 active site 315730014750 UGI interface [polypeptide binding]; other site 315730014751 catalytic site [active] 315730014752 ABC-2 type transporter; Region: ABC2_membrane; cl11417 315730014753 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 315730014754 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 315730014755 Walker A/P-loop; other site 315730014756 ATP binding site [chemical binding]; other site 315730014757 Q-loop/lid; other site 315730014758 ABC transporter signature motif; other site 315730014759 Walker B; other site 315730014760 D-loop; other site 315730014761 H-loop/switch region; other site 315730014762 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 315730014763 active site 315730014764 catalytic triad [active] 315730014765 oxyanion hole [active] 315730014766 Transcriptional regulators [Transcription]; Region: PurR; COG1609 315730014767 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 315730014768 DNA binding site [nucleotide binding] 315730014769 domain linker motif; other site 315730014770 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 315730014771 putative dimerization interface [polypeptide binding]; other site 315730014772 putative ligand binding site [chemical binding]; other site 315730014773 Predicted membrane protein [Function unknown]; Region: COG2364 315730014774 homoserine dehydrogenase; Provisional; Region: PRK06349 315730014775 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730014776 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 315730014777 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 315730014778 Homoserine O-succinyltransferase; Region: HTS; pfam04204 315730014779 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 315730014780 proposed active site lysine [active] 315730014781 conserved cys residue [active] 315730014782 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06702 315730014783 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 315730014784 homodimer interface [polypeptide binding]; other site 315730014785 substrate-cofactor binding pocket; other site 315730014786 pyridoxal 5'-phosphate binding site [chemical binding]; other site 315730014787 catalytic residue [active] 315730014788 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 315730014789 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 315730014790 Cl- selectivity filter; other site 315730014791 Cl- binding residues [ion binding]; other site 315730014792 pore gating glutamate residue; other site 315730014793 dimer interface [polypeptide binding]; other site 315730014794 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 315730014795 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 315730014796 active site 315730014797 motif I; other site 315730014798 motif II; other site 315730014799 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 315730014800 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 315730014801 ligand binding site [chemical binding]; other site 315730014802 flexible hinge region; other site 315730014803 Helix-turn-helix domains; Region: HTH; cl00088 315730014804 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 315730014805 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 315730014806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730014807 active site 315730014808 phosphorylation site [posttranslational modification] 315730014809 intermolecular recognition site; other site 315730014810 dimerization interface [polypeptide binding]; other site 315730014811 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 315730014812 DNA binding residues [nucleotide binding] 315730014813 dimerization interface [polypeptide binding]; other site 315730014814 GAF domain; Region: GAF; cl15785 315730014815 GAF domain; Region: GAF_2; pfam13185 315730014816 GAF domain; Region: GAF; cl15785 315730014817 Histidine kinase; Region: HisKA_3; pfam07730 315730014818 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 315730014819 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 315730014820 dimer interface [polypeptide binding]; other site 315730014821 substrate binding site [chemical binding]; other site 315730014822 ATP binding site [chemical binding]; other site 315730014823 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 315730014824 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 315730014825 metal binding site [ion binding]; metal-binding site 315730014826 active site 315730014827 I-site; other site 315730014828 Protein of unknown function (DUF466); Region: DUF466; cl01082 315730014829 carbon starvation protein A; Provisional; Region: PRK15015 315730014830 Carbon starvation protein CstA; Region: CstA; pfam02554 315730014831 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 315730014832 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 315730014833 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730014834 active site 315730014835 phosphorylation site [posttranslational modification] 315730014836 intermolecular recognition site; other site 315730014837 dimerization interface [polypeptide binding]; other site 315730014838 LytTr DNA-binding domain; Region: LytTR; cl04498 315730014839 benzoate transport; Region: 2A0115; TIGR00895 315730014840 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730014841 putative substrate translocation pore; other site 315730014842 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 315730014843 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 315730014844 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 315730014845 Predicted membrane protein [Function unknown]; Region: COG2860 315730014846 UPF0126 domain; Region: UPF0126; pfam03458 315730014847 UPF0126 domain; Region: UPF0126; pfam03458 315730014848 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 315730014849 heme-binding site [chemical binding]; other site 315730014850 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 315730014851 dimer interface [polypeptide binding]; other site 315730014852 putative CheW interface [polypeptide binding]; other site 315730014853 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 315730014854 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 315730014855 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 315730014856 Ligand binding site; other site 315730014857 Putative Catalytic site; other site 315730014858 DXD motif; other site 315730014859 MatE; Region: MatE; cl10513 315730014860 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 315730014861 active site 315730014862 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 315730014863 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 315730014864 Walker A/P-loop; other site 315730014865 ATP binding site [chemical binding]; other site 315730014866 Q-loop/lid; other site 315730014867 ABC transporter signature motif; other site 315730014868 Walker B; other site 315730014869 D-loop; other site 315730014870 H-loop/switch region; other site 315730014871 ABC transporter; Region: ABC_tran_2; pfam12848 315730014872 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 315730014873 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 315730014874 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 315730014875 Helix-turn-helix domains; Region: HTH; cl00088 315730014876 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 315730014877 Protein export membrane protein; Region: SecD_SecF; cl14618 315730014878 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 315730014879 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 315730014880 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 315730014881 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 315730014882 LrgB-like family; Region: LrgB; cl00596 315730014883 LrgA family; Region: LrgA; cl00608 315730014884 two-component response regulator; Provisional; Region: PRK14084 315730014885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730014886 active site 315730014887 phosphorylation site [posttranslational modification] 315730014888 intermolecular recognition site; other site 315730014889 dimerization interface [polypeptide binding]; other site 315730014890 LytTr DNA-binding domain; Region: LytTR; cl04498 315730014891 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 315730014892 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 315730014893 GAF domain; Region: GAF; cl15785 315730014894 Histidine kinase; Region: His_kinase; pfam06580 315730014895 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730014896 ATP binding site [chemical binding]; other site 315730014897 Mg2+ binding site [ion binding]; other site 315730014898 G-X-G motif; other site 315730014899 benzoate transport; Region: 2A0115; TIGR00895 315730014900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 315730014901 putative substrate translocation pore; other site 315730014902 BCCT family transporter; Region: BCCT; cl00569 315730014903 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N...; Region: NOS_oxygenase_prok; cd00794 315730014904 active site 315730014905 dimer interface [polypeptide binding]; other site 315730014906 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 315730014907 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 315730014908 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 315730014909 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 315730014910 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730014911 NAD(P) binding site [chemical binding]; other site 315730014912 active site 315730014913 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 315730014914 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 315730014915 Predicted membrane protein [Function unknown]; Region: COG4267 315730014916 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 315730014917 UDP-glucose 4-epimerase; Region: PLN02240 315730014918 NAD binding site [chemical binding]; other site 315730014919 homodimer interface [polypeptide binding]; other site 315730014920 active site 315730014921 substrate binding site [chemical binding]; other site 315730014922 Haemolysin-III related; Region: HlyIII; cl03831 315730014923 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 315730014924 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 315730014925 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 315730014926 ATP binding site [chemical binding]; other site 315730014927 Mg++ binding site [ion binding]; other site 315730014928 motif III; other site 315730014929 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 315730014930 nucleotide binding region [chemical binding]; other site 315730014931 ATP-binding site [chemical binding]; other site 315730014932 DbpA RNA binding domain; Region: DbpA; pfam03880 315730014933 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 315730014934 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 315730014935 active site 315730014936 oligoendopeptidase F; Region: pepF; TIGR00181 315730014937 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 315730014938 active site 315730014939 Zn binding site [ion binding]; other site 315730014940 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 315730014941 FeS/SAM binding site; other site 315730014942 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 315730014943 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 315730014944 YyzF-like protein; Region: YyzF; cl15733 315730014945 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 315730014946 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 315730014947 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 315730014948 protein binding site [polypeptide binding]; other site 315730014949 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 315730014950 YycH protein; Region: YycI; cl02015 315730014951 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 315730014952 YycH protein; Region: YycH; pfam07435 315730014953 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 315730014954 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 315730014955 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 315730014956 dimerization interface [polypeptide binding]; other site 315730014957 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 315730014958 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 315730014959 dimer interface [polypeptide binding]; other site 315730014960 phosphorylation site [posttranslational modification] 315730014961 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 315730014962 ATP binding site [chemical binding]; other site 315730014963 Mg2+ binding site [ion binding]; other site 315730014964 G-X-G motif; other site 315730014965 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 315730014966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 315730014967 active site 315730014968 phosphorylation site [posttranslational modification] 315730014969 intermolecular recognition site; other site 315730014970 dimerization interface [polypeptide binding]; other site 315730014971 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 315730014972 DNA binding site [nucleotide binding] 315730014973 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 315730014974 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 315730014975 GDP-binding site [chemical binding]; other site 315730014976 ACT binding site; other site 315730014977 IMP binding site; other site 315730014978 replicative DNA helicase; Provisional; Region: PRK05748 315730014979 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 315730014980 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 315730014981 Walker A motif; other site 315730014982 ATP binding site [chemical binding]; other site 315730014983 Walker B motif; other site 315730014984 DNA binding loops [nucleotide binding] 315730014985 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 315730014986 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 315730014987 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 315730014988 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 315730014989 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 315730014990 DHH family; Region: DHH; pfam01368 315730014991 DHHA1 domain; Region: DHHA1; pfam02272 315730014992 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 315730014993 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 315730014994 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 315730014995 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 315730014996 dimer interface [polypeptide binding]; other site 315730014997 ssDNA binding site [nucleotide binding]; other site 315730014998 tetramer (dimer of dimers) interface [polypeptide binding]; other site 315730014999 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 315730015000 GTP-binding protein YchF; Reviewed; Region: PRK09601 315730015001 YchF GTPase; Region: YchF; cd01900 315730015002 G1 box; other site 315730015003 GTP/Mg2+ binding site [chemical binding]; other site 315730015004 Switch I region; other site 315730015005 G2 box; other site 315730015006 Switch II region; other site 315730015007 G3 box; other site 315730015008 G4 box; other site 315730015009 G5 box; other site 315730015010 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 315730015011 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 315730015012 Mechanosensitive ion channel; Region: MS_channel; pfam00924 315730015013 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 315730015014 ParB-like partition proteins; Region: parB_part; TIGR00180 315730015015 ParB-like nuclease domain; Region: ParBc; cl02129 315730015016 KorB domain; Region: KorB; pfam08535 315730015017 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 315730015018 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 315730015019 P-loop; other site 315730015020 Magnesium ion binding site [ion binding]; other site 315730015021 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 315730015022 Magnesium ion binding site [ion binding]; other site 315730015023 ParB-like partition proteins; Region: parB_part; TIGR00180 315730015024 ParB-like nuclease domain; Region: ParBc; cl02129 315730015025 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 315730015026 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 315730015027 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 315730015028 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 315730015029 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 315730015030 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 315730015031 trmE is a tRNA modification GTPase; Region: trmE; cd04164 315730015032 G1 box; other site 315730015033 GTP/Mg2+ binding site [chemical binding]; other site 315730015034 Switch I region; other site 315730015035 G2 box; other site 315730015036 Switch II region; other site 315730015037 G3 box; other site 315730015038 G4 box; other site 315730015039 G5 box; other site 315730015040 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 315730015041 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 315730015042 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 315730015043 G-X-X-G motif; other site 315730015044 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 315730015045 RxxxH motif; other site 315730015046 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 315730015047 Ribonuclease P; Region: Ribonuclease_P; cl00457 315730015048 Ribosomal protein L34; Region: Ribosomal_L34; cl00370