-- dump date   	20120504_134542
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
435590000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
435590000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
435590000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590000004	Walker A motif; other site
435590000005	ATP binding site [chemical binding]; other site
435590000006	Walker B motif; other site
435590000007	arginine finger; other site
435590000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
435590000009	DnaA box-binding interface [nucleotide binding]; other site
435590000010	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
435590000011	dimer interface [polypeptide binding]; other site
435590000012	FMN binding site [chemical binding]; other site
435590000013	NADPH bind site [chemical binding]; other site
435590000014	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
435590000015	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
435590000016	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
435590000017	active site
435590000018	dimer interface [polypeptide binding]; other site
435590000019	effector binding site; other site
435590000020	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
435590000021	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665
435590000022	AsmA-like C-terminal region; Region: AsmA_2; cl15864
435590000023	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
435590000024	homooctamer interface [polypeptide binding]; other site
435590000025	active site
435590000026	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590000027	Radical SAM superfamily; Region: Radical_SAM; pfam04055
435590000028	FeS/SAM binding site; other site
435590000029	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
435590000030	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
435590000031	Probable Catalytic site; other site
435590000032	metal-binding site
435590000033	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
435590000034	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
435590000035	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590000036	FeS/SAM binding site; other site
435590000037	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
435590000038	AMP-binding enzyme; Region: AMP-binding; cl15778
435590000039	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
435590000040	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
435590000041	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
435590000042	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
435590000043	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
435590000044	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
435590000045	Helix-turn-helix domains; Region: HTH; cl00088
435590000046	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
435590000047	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590000048	active site
435590000049	phosphorylation site [posttranslational modification]
435590000050	intermolecular recognition site; other site
435590000051	dimerization interface [polypeptide binding]; other site
435590000052	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
435590000053	DNA binding site [nucleotide binding]
435590000054	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590000055	dimer interface [polypeptide binding]; other site
435590000056	phosphorylation site [posttranslational modification]
435590000057	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590000058	ATP binding site [chemical binding]; other site
435590000059	Mg2+ binding site [ion binding]; other site
435590000060	G-X-G motif; other site
435590000061	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
435590000062	elongation factor G; Reviewed; Region: PRK12740
435590000063	G1 box; other site
435590000064	putative GEF interaction site [polypeptide binding]; other site
435590000065	GTP/Mg2+ binding site [chemical binding]; other site
435590000066	Switch I region; other site
435590000067	G2 box; other site
435590000068	G3 box; other site
435590000069	Switch II region; other site
435590000070	G4 box; other site
435590000071	G5 box; other site
435590000072	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
435590000073	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
435590000074	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
435590000075	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
435590000076	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590000077	FeS/SAM binding site; other site
435590000078	HemN C-terminal domain; Region: HemN_C; pfam06969
435590000079	Secretin and TonB N terminus short domain; Region: STN; cl06624
435590000080	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590000081	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590000082	Transposase domain (DUF772); Region: DUF772; cl15789
435590000083	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590000084	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590000085	Domain of unknown function (DUF4249); Region: DUF4249; pfam14054
435590000086	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590000087	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590000088	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
435590000089	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
435590000090	FecR protein; Region: FecR; pfam04773
435590000091	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590000092	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590000093	Domain of unknown function (DUF4249); Region: DUF4249; pfam14054
435590000094	Domain of unknown function (DUF303); Region: DUF303; pfam03629
435590000095	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
435590000096	Domain of unknown function (DUF303); Region: DUF303; pfam03629
435590000097	Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661
435590000098	Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477
435590000099	Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648
435590000100	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001
435590000101	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
435590000102	active site
435590000103	Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990
435590000104	substrate binding site [chemical binding]; other site
435590000105	active site
435590000106	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
435590000107	metal binding site [ion binding]; metal-binding site
435590000108	ligand binding site [chemical binding]; other site
435590000109	N-terminal Early set domain associated with the catalytic domain of esterase; Region: E_set_Esterase_N; cd02858
435590000110	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
435590000111	Putative esterase; Region: Esterase; pfam00756
435590000112	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
435590000113	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590000114	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590000115	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590000116	dimer interface [polypeptide binding]; other site
435590000117	phosphorylation site [posttranslational modification]
435590000118	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590000119	ATP binding site [chemical binding]; other site
435590000120	Mg2+ binding site [ion binding]; other site
435590000121	G-X-G motif; other site
435590000122	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
435590000123	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590000124	active site
435590000125	phosphorylation site [posttranslational modification]
435590000126	intermolecular recognition site; other site
435590000127	dimerization interface [polypeptide binding]; other site
435590000128	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590000129	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590000130	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
435590000131	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
435590000132	Integrase core domain; Region: rve; cl01316
435590000133	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
435590000134	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
435590000135	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590000136	SusD family; Region: SusD; pfam07980
435590000137	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590000138	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590000139	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590000140	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
435590000141	inhibitor binding site; inhibition site
435590000142	active site
435590000143	Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990
435590000144	substrate binding site [chemical binding]; other site
435590000145	active site
435590000146	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
435590000147	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
435590000148	Transposase; Region: DEDD_Tnp_IS110; pfam01548
435590000149	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
435590000150	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
435590000151	MFS/sugar transport protein; Region: MFS_2; pfam13347
435590000152	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
435590000153	active site
435590000154	catalytic residues [active]
435590000155	Transposase domain (DUF772); Region: DUF772; cl15789
435590000156	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590000157	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
435590000158	This PGM-like (phosphoglucomutase-like) domain is located C-terminal to a mannose-1-phosphate guanyltransferase domain in a protein of unknown function that is found in both prokaryotes and eukaryotes. This domain belongs to the alpha-D-phosphohexomutase...; Region: PGM_like4; cd05803
435590000159	active site
435590000160	substrate binding site [chemical binding]; other site
435590000161	metal binding site [ion binding]; metal-binding site
435590000162	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
435590000163	DHH family; Region: DHH; pfam01368
435590000164	DHHA1 domain; Region: DHHA1; pfam02272
435590000165	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
435590000166	Competence protein; Region: Competence; cl00471
435590000167	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
435590000168	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
435590000169	substrate binding site [chemical binding]; other site
435590000170	hexamer interface [polypeptide binding]; other site
435590000171	metal binding site [ion binding]; metal-binding site
435590000172	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
435590000173	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
435590000174	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590000175	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590000176	DNA binding residues [nucleotide binding]
435590000177	NigD-like protein; Region: NigD; pfam12667
435590000178	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
435590000179	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
435590000180	putative active site [active]
435590000181	substrate binding site [chemical binding]; other site
435590000182	putative cosubstrate binding site; other site
435590000183	catalytic site [active]
435590000184	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
435590000185	substrate binding site [chemical binding]; other site
435590000186	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
435590000187	Voltage gated chloride channel; Region: Voltage_CLC; pfam00654
435590000188	Cl- selectivity filter; other site
435590000189	Cl- binding residues [ion binding]; other site
435590000190	pore gating glutamate residue; other site
435590000191	dimer interface [polypeptide binding]; other site
435590000192	FOG: CBS domain [General function prediction only]; Region: COG0517
435590000193	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613
435590000194	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
435590000195	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
435590000196	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
435590000197	active site
435590000198	dimer interface [polypeptide binding]; other site
435590000199	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
435590000200	Protein export membrane protein; Region: SecD_SecF; cl14618
435590000201	Protein export membrane protein; Region: SecD_SecF; cl14618
435590000202	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
435590000203	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
435590000204	Protein export membrane protein; Region: SecD_SecF; cl14618
435590000205	Protein export membrane protein; Region: SecD_SecF; cl14618
435590000206	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
435590000207	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
435590000208	O-Antigen ligase; Region: Wzy_C; cl04850
435590000209	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
435590000210	binding surface
435590000211	TPR motif; other site
435590000212	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
435590000213	signal peptidase I; Provisional; Region: PRK10861
435590000214	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
435590000215	Catalytic site [active]
435590000216	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
435590000217	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
435590000218	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
435590000219	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
435590000220	DNA binding site [nucleotide binding]
435590000221	L-aspartate dehydrogenase; Reviewed; Region: PRK13304
435590000222	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590000223	Domain of unknown function DUF108; Region: DUF108; pfam01958
435590000224	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
435590000225	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590000226	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
435590000227	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
435590000228	putative metal binding site [ion binding]; other site
435590000229	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
435590000230	HSP70 interaction site [polypeptide binding]; other site
435590000231	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
435590000232	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
435590000233	G1 box; other site
435590000234	putative GEF interaction site [polypeptide binding]; other site
435590000235	GTP/Mg2+ binding site [chemical binding]; other site
435590000236	Switch I region; other site
435590000237	G2 box; other site
435590000238	G3 box; other site
435590000239	Switch II region; other site
435590000240	G4 box; other site
435590000241	G5 box; other site
435590000242	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
435590000243	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
435590000244	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
435590000245	NADP binding site [chemical binding]; other site
435590000246	active site
435590000247	putative substrate binding site [chemical binding]; other site
435590000248	LysE type translocator; Region: LysE; cl00565
435590000249	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
435590000250	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
435590000251	dimerization interface [polypeptide binding]; other site
435590000252	ATP binding site [chemical binding]; other site
435590000253	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
435590000254	dimerization interface [polypeptide binding]; other site
435590000255	ATP binding site [chemical binding]; other site
435590000256	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
435590000257	putative active site [active]
435590000258	catalytic triad [active]
435590000259	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590000260	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590000261	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590000262	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590000263	dimer interface [polypeptide binding]; other site
435590000264	phosphorylation site [posttranslational modification]
435590000265	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590000266	ATP binding site [chemical binding]; other site
435590000267	Mg2+ binding site [ion binding]; other site
435590000268	G-X-G motif; other site
435590000269	Response regulator receiver domain; Region: Response_reg; pfam00072
435590000270	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590000271	active site
435590000272	phosphorylation site [posttranslational modification]
435590000273	intermolecular recognition site; other site
435590000274	dimerization interface [polypeptide binding]; other site
435590000275	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590000276	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590000277	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
435590000278	Chromate transporter; Region: Chromate_transp; pfam02417
435590000279	Chromate transporter; Region: Chromate_transp; pfam02417
435590000280	Uncharacterized BCR, COG1649; Region: DUF187; cl15398
435590000281	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
435590000282	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
435590000283	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
435590000284	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
435590000285	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
435590000286	putative catalytic site [active]
435590000287	putative metal binding site [ion binding]; other site
435590000288	putative phosphate binding site [ion binding]; other site
435590000289	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
435590000290	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
435590000291	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
435590000292	active site
435590000293	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
435590000294	PA14 domain; Region: PA14; cl08459
435590000295	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
435590000296	Carbon starvation protein CstA; Region: CstA; pfam02554
435590000297	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
435590000298	Uncharacterized BCR, COG1649; Region: DUF187; cl15398
435590000299	Virulence protein [General function prediction only]; Region: COG3943
435590000300	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
435590000301	phosphoribosylaminoimidazole synthetase; Region: purM; TIGR00878
435590000302	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
435590000303	dimerization interface [polypeptide binding]; other site
435590000304	ATP binding site [chemical binding]; other site
435590000305	peptide chain release factor 1; Validated; Region: prfA; PRK00591
435590000306	RF-1 domain; Region: RF-1; cl02875
435590000307	RF-1 domain; Region: RF-1; cl02875
435590000308	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725
435590000309	active site
435590000310	dimer interface [polypeptide binding]; other site
435590000311	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
435590000312	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
435590000313	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
435590000314	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
435590000315	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
435590000316	trimer interface [polypeptide binding]; other site
435590000317	active site
435590000318	UDP-GlcNAc binding site [chemical binding]; other site
435590000319	lipid binding site [chemical binding]; lipid-binding site
435590000320	bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188
435590000321	UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512
435590000322	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
435590000323	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
435590000324	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
435590000325	active site
435590000326	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
435590000327	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590000328	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
435590000329	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
435590000330	Right handed beta helix region; Region: Beta_helix; pfam13229
435590000331	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
435590000332	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590000333	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590000334	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590000335	Secretin and TonB N terminus short domain; Region: STN; cl06624
435590000336	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590000337	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590000338	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590000339	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
435590000340	FecR protein; Region: FecR; pfam04773
435590000341	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590000342	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590000343	DNA binding residues [nucleotide binding]
435590000344	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
435590000345	catalytic residues [active]
435590000346	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
435590000347	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
435590000348	catalytic residues [active]
435590000349	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
435590000350	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590000351	binding surface
435590000352	TPR motif; other site
435590000353	BlaR1 peptidase M56; Region: Peptidase_M56; cl15829
435590000354	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590000355	Gram-negative bacterial tonB protein; Region: TonB; cl10048
435590000356	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590000357	Helix-turn-helix domains; Region: HTH; cl00088
435590000358	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
435590000359	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
435590000360	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001
435590000361	active site
435590000362	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
435590000363	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
435590000364	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
435590000365	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
435590000366	Glycosyl hydrolase family 49; Region: Glyco_hydro_49; pfam03718
435590000367	Glycosyl hydrolase 43-like family consists of hypothetical proteins; Region: GH43_like_2; cd08994
435590000368	active site
435590000369	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
435590000370	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
435590000371	Glycosyl hydrolase family 49; Region: Glyco_hydro_49; pfam03718
435590000372	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590000373	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590000374	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590000375	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590000376	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590000377	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590000378	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590000379	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
435590000380	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590000381	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590000382	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590000383	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
435590000384	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590000385	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
435590000386	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
435590000387	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
435590000388	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
435590000389	Fibronectin type III-like domain; Region: Fn3-like; cl15273
435590000390	Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179
435590000391	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
435590000392	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; cl15460
435590000393	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
435590000394	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590000395	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590000396	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590000397	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590000398	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590000399	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590000400	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590000401	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
435590000402	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
435590000403	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590000404	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590000405	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590000406	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
435590000407	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
435590000408	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
435590000409	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
435590000410	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
435590000411	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
435590000412	dimerization interface [polypeptide binding]; other site
435590000413	active site
435590000414	aspartate aminotransferase; Provisional; Region: PRK05764
435590000415	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
435590000416	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590000417	homodimer interface [polypeptide binding]; other site
435590000418	catalytic residue [active]
435590000419	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
435590000420	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
435590000421	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
435590000422	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
435590000423	active site
435590000424	metal binding site [ion binding]; metal-binding site
435590000425	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
435590000426	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
435590000427	Two component regulator propeller; Region: Reg_prop; pfam07494
435590000428	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590000429	Two component regulator propeller; Region: Reg_prop; pfam07494
435590000430	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590000431	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590000432	dimer interface [polypeptide binding]; other site
435590000433	phosphorylation site [posttranslational modification]
435590000434	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590000435	ATP binding site [chemical binding]; other site
435590000436	Mg2+ binding site [ion binding]; other site
435590000437	G-X-G motif; other site
435590000438	Response regulator receiver domain; Region: Response_reg; pfam00072
435590000439	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590000440	active site
435590000441	phosphorylation site [posttranslational modification]
435590000442	intermolecular recognition site; other site
435590000443	dimerization interface [polypeptide binding]; other site
435590000444	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590000445	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590000446	Domain of unknown function (DUF718); Region: DUF718; cl01281
435590000447	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
435590000448	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
435590000449	metal binding site [ion binding]; metal-binding site
435590000450	active site
435590000451	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
435590000452	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
435590000453	Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648
435590000454	Transposase [DNA replication, recombination, and repair]; Region: COG5433
435590000455	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
435590000456	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590000457	Transposase [DNA replication, recombination, and repair]; Region: COG5433
435590000458	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
435590000459	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
435590000460	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
435590000461	active site
435590000462	catalytic triad [active]
435590000463	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
435590000464	active site
435590000465	catalytic triad [active]
435590000466	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
435590000467	metal binding site [ion binding]; metal-binding site
435590000468	active site
435590000469	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
435590000470	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590000471	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
435590000472	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
435590000473	Sulfatase; Region: Sulfatase; cl10460
435590000474	translocation protein TolB; Provisional; Region: tolB; PRK04792
435590000475	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590000476	SusD family; Region: SusD; pfam07980
435590000477	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590000478	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590000479	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590000480	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
435590000481	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590000482	DNA binding site [nucleotide binding]
435590000483	Int/Topo IB signature motif; other site
435590000484	active site
435590000485	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590000486	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590000487	Transposase domain (DUF772); Region: DUF772; cl15789
435590000488	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590000489	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590000490	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590000491	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590000492	SusD family; Region: SusD; pfam07980
435590000493	SusD family; Region: SusD; pfam07980
435590000494	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801
435590000495	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
435590000496	metal binding site [ion binding]; metal-binding site
435590000497	Family description; Region: VCBS; pfam13517
435590000498	active site
435590000499	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
435590000500	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
435590000501	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
435590000502	Beta-galactosidase; Region: Glyco_hydro_42; cl03154
435590000503	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
435590000504	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
435590000505	active site
435590000506	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
435590000507	active site
435590000508	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
435590000509	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
435590000510	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590000511	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
435590000512	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
435590000513	active site
435590000514	catalytic triad [active]
435590000515	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
435590000516	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
435590000517	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
435590000518	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
435590000519	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
435590000520	catalytic nucleophile [active]
435590000521	Domain of unknown function (DUF718); Region: DUF718; cl01281
435590000522	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
435590000523	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
435590000524	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
435590000525	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
435590000526	Walker A/P-loop; other site
435590000527	ATP binding site [chemical binding]; other site
435590000528	Q-loop/lid; other site
435590000529	ABC transporter signature motif; other site
435590000530	Walker B; other site
435590000531	D-loop; other site
435590000532	H-loop/switch region; other site
435590000533	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590000534	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
435590000535	FtsX-like permease family; Region: FtsX; cl15850
435590000536	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590000537	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
435590000538	FtsX-like permease family; Region: FtsX; cl15850
435590000539	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
435590000540	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
435590000541	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
435590000542	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
435590000543	Transposase domain (DUF772); Region: DUF772; cl15789
435590000544	Transposase domain (DUF772); Region: DUF772; cl15789
435590000545	transcription termination factor Rho; Provisional; Region: PRK12678
435590000546	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
435590000547	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
435590000548	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
435590000549	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
435590000550	dimer interface [polypeptide binding]; other site
435590000551	active site
435590000552	metal binding site [ion binding]; metal-binding site
435590000553	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
435590000554	Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842
435590000555	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
435590000556	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
435590000557	Walker A/P-loop; other site
435590000558	ATP binding site [chemical binding]; other site
435590000559	Q-loop/lid; other site
435590000560	ABC transporter signature motif; other site
435590000561	Walker B; other site
435590000562	D-loop; other site
435590000563	H-loop/switch region; other site
435590000564	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
435590000565	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
435590000566	putative ATP binding site [chemical binding]; other site
435590000567	putative substrate interface [chemical binding]; other site
435590000568	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
435590000569	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
435590000570	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
435590000571	Ligand Binding Site [chemical binding]; other site
435590000572	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
435590000573	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590000574	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
435590000575	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
435590000576	glycyl-tRNA synthetase; Provisional; Region: PRK04173
435590000577	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
435590000578	motif 1; other site
435590000579	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774
435590000580	active site
435590000581	motif 2; other site
435590000582	motif 3; other site
435590000583	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
435590000584	anticodon binding site; other site
435590000585	DNA topoisomerase IV subunit A; Provisional; Region: PRK12758
435590000586	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cl00148
435590000587	CAP-like domain; other site
435590000588	active site
435590000589	primary dimer interface [polypeptide binding]; other site
435590000590	Protein of unknown function (DUF3316); Region: DUF3316; pfam11777
435590000591	Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563
435590000592	active site triad [active]
435590000593	XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591
435590000594	putative active site [active]
435590000595	putative catalytic site [active]
435590000596	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
435590000597	Domain of unknown function (DUF718); Region: DUF718; cl01281
435590000598	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590000599	SusD family; Region: SusD; pfam07980
435590000600	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590000601	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590000602	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590000603	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590000604	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
435590000605	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590000606	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590000607	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590000608	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
435590000609	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
435590000610	active site
435590000611	catalytic tetrad [active]
435590000612	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
435590000613	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
435590000614	active site
435590000615	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
435590000616	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
435590000617	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
435590000618	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
435590000619	putative NAD(P) binding site [chemical binding]; other site
435590000620	catalytic Zn binding site [ion binding]; other site
435590000621	structural Zn binding site [ion binding]; other site
435590000622	MarC family integral membrane protein; Region: MarC; cl00919
435590000623	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
435590000624	trimer interface [polypeptide binding]; other site
435590000625	active site
435590000626	substrate binding site [chemical binding]; other site
435590000627	CoA binding site [chemical binding]; other site
435590000628	MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738
435590000629	SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825
435590000630	active site
435590000631	catalytic triad [active]
435590000632	oxyanion hole [active]
435590000633	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
435590000634	SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825
435590000635	active site
435590000636	catalytic triad [active]
435590000637	oxyanion hole [active]
435590000638	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
435590000639	Protein export membrane protein; Region: SecD_SecF; cl14618
435590000640	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
435590000641	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
435590000642	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
435590000643	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
435590000644	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
435590000645	Helix-turn-helix domains; Region: HTH; cl00088
435590000646	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK12461
435590000647	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
435590000648	active site
435590000649	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
435590000650	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
435590000651	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
435590000652	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
435590000653	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
435590000654	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
435590000655	Malic enzyme, N-terminal domain; Region: malic; pfam00390
435590000656	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
435590000657	putative NAD(P) binding site [chemical binding]; other site
435590000658	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
435590000659	glutamate dehydrogenase; Provisional; Region: PRK14031
435590000660	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
435590000661	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
435590000662	NAD(P) binding site [chemical binding]; other site
435590000663	Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201
435590000664	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
435590000665	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
435590000666	intermolecular recognition site; other site
435590000667	acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361
435590000668	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
435590000669	glutamate dehydrogenase; Provisional; Region: PRK14030
435590000670	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
435590000671	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
435590000672	NAD(P) binding site [chemical binding]; other site
435590000673	Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969
435590000674	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
435590000675	Active Sites [active]
435590000676	Domain of unknown function (DUF3440); Region: DUF3440; pfam11922
435590000677	ParB-like nuclease domain; Region: ParBc; cl02129
435590000678	Protein of unknown function (DUF3988); Region: DUF3988; pfam13149
435590000679	malate dehydrogenase; Reviewed; Region: PRK06223
435590000680	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
435590000681	dimer interface [polypeptide binding]; other site
435590000682	NAD(P) binding site [chemical binding]; other site
435590000683	tetramer (dimer of dimers) interface [polypeptide binding]; other site
435590000684	substrate binding site [chemical binding]; other site
435590000685	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
435590000686	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
435590000687	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
435590000688	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
435590000689	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
435590000690	ABC-2 type transporter; Region: ABC2_membrane; cl11417
435590000691	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
435590000692	ABC-2 type transporter; Region: ABC2_membrane; cl11417
435590000693	extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502
435590000694	NlpE N-terminal domain; Region: NlpE; cl01138
435590000695	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
435590000696	Helix-turn-helix domains; Region: HTH; cl00088
435590000697	BlaR1 peptidase M56; Region: Peptidase_M56; cl15829
435590000698	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590000699	Gram-negative bacterial tonB protein; Region: TonB; cl10048
435590000700	Domain of unknown function DUF59; Region: DUF59; cl00941
435590000701	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
435590000702	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
435590000703	Protein of unknown function (DUF975); Region: DUF975; cl10504
435590000704	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
435590000705	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
435590000706	homodimer interface [polypeptide binding]; other site
435590000707	substrate-cofactor binding pocket; other site
435590000708	catalytic residue [active]
435590000709	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
435590000710	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
435590000711	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
435590000712	generic binding surface II; other site
435590000713	generic binding surface I; other site
435590000714	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
435590000715	Peptidase S8 family domain, uncharacterized subfamily 9; Region: Peptidases_S8_9; cd07493
435590000716	active site
435590000717	catalytic triad [active]
435590000718	multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575
435590000719	MatE; Region: MatE; cl10513
435590000720	MatE; Region: MatE; cl10513
435590000721	Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189
435590000722	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590000723	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
435590000724	Domain of unknown function (DUF3244); Region: DUF3244; pfam11589
435590000725	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296
435590000726	putative active site [active]
435590000727	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590000728	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590000729	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590000730	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590000731	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590000732	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590000733	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590000734	Radical SAM superfamily; Region: Radical_SAM; pfam04055
435590000735	FeS/SAM binding site; other site
435590000736	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
435590000737	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590000738	FeS/SAM binding site; other site
435590000739	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590000740	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590000741	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590000742	Domain of unknown function (DUF3244); Region: DUF3244; pfam11589
435590000743	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
435590000744	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39B; cd02418
435590000745	putative active site [active]
435590000746	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
435590000747	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590000748	Walker A/P-loop; other site
435590000749	ATP binding site [chemical binding]; other site
435590000750	Q-loop/lid; other site
435590000751	ABC transporter signature motif; other site
435590000752	Walker B; other site
435590000753	D-loop; other site
435590000754	H-loop/switch region; other site
435590000755	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
435590000756	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
435590000757	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590000758	FeS/SAM binding site; other site
435590000759	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
435590000760	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296
435590000761	putative active site [active]
435590000762	polyphosphate kinase; Provisional; Region: PRK05443
435590000763	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
435590000764	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
435590000765	Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164
435590000766	domain interface [polypeptide binding]; other site
435590000767	active site
435590000768	catalytic site [active]
435590000769	Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167
435590000770	domain interface [polypeptide binding]; other site
435590000771	active site
435590000772	catalytic site [active]
435590000773	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
435590000774	active site
435590000775	metal binding site [ion binding]; metal-binding site
435590000776	homotetramer interface [polypeptide binding]; other site
435590000777	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
435590000778	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
435590000779	NAD binding site [chemical binding]; other site
435590000780	substrate binding site [chemical binding]; other site
435590000781	homodimer interface [polypeptide binding]; other site
435590000782	active site
435590000783	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590000784	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590000785	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590000786	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590000787	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590000788	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590000789	beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525
435590000790	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
435590000791	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590000792	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
435590000793	Beta galactosidase small chain; Region: Bgal_small_N; cl03787
435590000794	alpha-glucosidase; Provisional; Region: PRK10137
435590000795	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801
435590000796	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590000797	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590000798	Secretin and TonB N terminus short domain; Region: STN; cl06624
435590000799	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590000800	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590000801	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590000802	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
435590000803	FecR protein; Region: FecR; pfam04773
435590000804	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590000805	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590000806	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590000807	DNA binding residues [nucleotide binding]
435590000808	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
435590000809	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
435590000810	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
435590000811	ABC transporter; Region: ABC_tran_2; pfam12848
435590000812	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
435590000813	putative transporter; Validated; Region: PRK03818
435590000814	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
435590000815	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
435590000816	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
435590000817	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
435590000818	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
435590000819	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
435590000820	heterodimer interface [polypeptide binding]; other site
435590000821	substrate interaction site [chemical binding]; other site
435590000822	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
435590000823	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
435590000824	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
435590000825	active site
435590000826	substrate binding site [chemical binding]; other site
435590000827	coenzyme B12 binding site [chemical binding]; other site
435590000828	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
435590000829	B12 binding site [chemical binding]; other site
435590000830	cobalt ligand [ion binding]; other site
435590000831	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590000832	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590000833	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590000834	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
435590000835	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
435590000836	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590000837	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590000838	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590000839	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590000840	ATP binding site [chemical binding]; other site
435590000841	Mg2+ binding site [ion binding]; other site
435590000842	G-X-G motif; other site
435590000843	Mechanosensitive ion channel; Region: MS_channel; pfam00924
435590000844	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
435590000845	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
435590000846	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
435590000847	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
435590000848	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
435590000849	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
435590000850	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
435590000851	NVEALA protein; Region: NVEALA; pfam14055
435590000852	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
435590000853	Ligand binding site [chemical binding]; other site
435590000854	Electron transfer flavoprotein domain; Region: ETF; pfam01012
435590000855	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
435590000856	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
435590000857	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
435590000858	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
435590000859	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
435590000860	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
435590000861	active site
435590000862	Acyl-CoA dehydrogenase C terminal; Region: AcylCoA_dehyd_C; pfam12186
435590000863	Histidine carboxylase PI chain; Region: HDC; cl03540
435590000864	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
435590000865	CoenzymeA binding site [chemical binding]; other site
435590000866	subunit interaction site [polypeptide binding]; other site
435590000867	PHB binding site; other site
435590000868	Domain of unknown function (DUF2027); Region: DUF2027; pfam09640
435590000869	Smr domain; Region: Smr; cl02619
435590000870	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
435590000871	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
435590000872	urocanate hydratase; Provisional; Region: PRK05414
435590000873	glutamate formiminotransferase; Region: FtcD; TIGR02024
435590000874	Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837
435590000875	Formiminotransferase domain; Region: FTCD; pfam02971
435590000876	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_3; pfam13366
435590000877	imidazolonepropionase; Validated; Region: PRK09356
435590000878	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
435590000879	active site
435590000880	Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350
435590000881	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
435590000882	active sites [active]
435590000883	tetramer interface [polypeptide binding]; other site
435590000884	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693
435590000885	nudix motif; other site
435590000886	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
435590000887	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590000888	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
435590000889	active site clefts [active]
435590000890	zinc binding site [ion binding]; other site
435590000891	dimer interface [polypeptide binding]; other site
435590000892	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
435590000893	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
435590000894	ligand binding site [chemical binding]; other site
435590000895	flexible hinge region; other site
435590000896	multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575
435590000897	MatE; Region: MatE; cl10513
435590000898	MatE; Region: MatE; cl10513
435590000899	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
435590000900	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
435590000901	ring oligomerisation interface [polypeptide binding]; other site
435590000902	ATP/Mg binding site [chemical binding]; other site
435590000903	stacking interactions; other site
435590000904	hinge regions; other site
435590000905	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
435590000906	oligomerisation interface [polypeptide binding]; other site
435590000907	mobile loop; other site
435590000908	roof hairpin; other site
435590000909	[FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105
435590000910	4Fe-4S binding domain; Region: Fer4; cl02805
435590000911	4Fe-4S binding domain; Region: Fer4; cl02805
435590000912	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
435590000913	[FeFe] hydrogenase H-cluster radical SAM maturase HydE; Region: rSAM_HydE; TIGR03956
435590000914	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590000915	FeS/SAM binding site; other site
435590000916	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
435590000917	[FeFe] hydrogenase H-cluster radical SAM maturase HydG; Region: rSAM_HydG; TIGR03955
435590000918	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590000919	FeS/SAM binding site; other site
435590000920	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
435590000921	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
435590000922	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
435590000923	G1 box; other site
435590000924	GTP/Mg2+ binding site [chemical binding]; other site
435590000925	Switch I region; other site
435590000926	G2 box; other site
435590000927	Switch II region; other site
435590000928	G3 box; other site
435590000929	G4 box; other site
435590000930	G5 box; other site
435590000931	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
435590000932	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
435590000933	dimer interface [polypeptide binding]; other site
435590000934	motif 1; other site
435590000935	active site
435590000936	motif 2; other site
435590000937	motif 3; other site
435590000938	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
435590000939	anticodon binding site; other site
435590000940	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
435590000941	Transposase; Region: DDE_Tnp_ISL3; pfam01610
435590000942	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
435590000943	ligand binding site [chemical binding]; other site
435590000944	Ureide permease; Region: Ureide_permease; pfam07168
435590000945	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
435590000946	L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407
435590000947	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578
435590000948	hexamer (dimer of trimers) interface [polypeptide binding]; other site
435590000949	substrate binding site [chemical binding]; other site
435590000950	trimer interface [polypeptide binding]; other site
435590000951	Mn binding site [ion binding]; other site
435590000952	uncharacterized subgroup; belongs to the glycerol kinases subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GK_1; cd10427
435590000953	putative N- and C-terminal domain interface [polypeptide binding]; other site
435590000954	glycerol kinase; Provisional; Region: glpK; PRK00047
435590000955	putative active site [active]
435590000956	putative MgATP binding site [chemical binding]; other site
435590000957	catalytic site [active]
435590000958	metal binding site [ion binding]; metal-binding site
435590000959	putative glycerol binding site [chemical binding]; other site
435590000960	putative homotetramer interface [polypeptide binding]; other site
435590000961	putative homodimer interface [polypeptide binding]; other site
435590000962	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
435590000963	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
435590000964	PYR/PP interface [polypeptide binding]; other site
435590000965	dimer interface [polypeptide binding]; other site
435590000966	TPP binding site [chemical binding]; other site
435590000967	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
435590000968	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
435590000969	TPP-binding site [chemical binding]; other site
435590000970	dimer interface [polypeptide binding]; other site
435590000971	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
435590000972	Helix-turn-helix domains; Region: HTH; cl00088
435590000973	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
435590000974	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
435590000975	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
435590000976	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
435590000977	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590000978	Two component regulator propeller; Region: Reg_prop; pfam07494
435590000979	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590000980	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
435590000981	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590000982	dimer interface [polypeptide binding]; other site
435590000983	phosphorylation site [posttranslational modification]
435590000984	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590000985	ATP binding site [chemical binding]; other site
435590000986	Mg2+ binding site [ion binding]; other site
435590000987	G-X-G motif; other site
435590000988	Response regulator receiver domain; Region: Response_reg; pfam00072
435590000989	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590000990	active site
435590000991	phosphorylation site [posttranslational modification]
435590000992	intermolecular recognition site; other site
435590000993	dimerization interface [polypeptide binding]; other site
435590000994	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590000995	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590000996	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590000997	SusD family; Region: SusD; pfam07980
435590000998	Secretin and TonB N terminus short domain; Region: STN; cl06624
435590000999	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590001000	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590001001	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590001002	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
435590001003	FecR protein; Region: FecR; pfam04773
435590001004	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590001005	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590001006	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590001007	DNA binding residues [nucleotide binding]
435590001008	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801
435590001009	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
435590001010	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
435590001011	Integrase core domain; Region: rve; cl01316
435590001012	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
435590001013	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
435590001014	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049
435590001015	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590001016	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
435590001017	active site
435590001018	Surface antigen; Region: Bac_surface_Ag; cl03097
435590001019	Family of unknown function (DUF490); Region: DUF490; pfam04357
435590001020	Family of unknown function (DUF490); Region: DUF490; pfam04357
435590001021	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
435590001022	active site
435590001023	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
435590001024	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
435590001025	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
435590001026	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
435590001027	putative efflux protein, MATE family; Region: matE; TIGR00797
435590001028	MatE; Region: MatE; cl10513
435590001029	MatE; Region: MatE; cl10513
435590001030	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590001031	dimer interface [polypeptide binding]; other site
435590001032	phosphorylation site [posttranslational modification]
435590001033	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590001034	ATP binding site [chemical binding]; other site
435590001035	Mg2+ binding site [ion binding]; other site
435590001036	G-X-G motif; other site
435590001037	Response regulator receiver domain; Region: Response_reg; pfam00072
435590001038	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590001039	active site
435590001040	phosphorylation site [posttranslational modification]
435590001041	intermolecular recognition site; other site
435590001042	dimerization interface [polypeptide binding]; other site
435590001043	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
435590001044	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590001045	active site
435590001046	phosphorylation site [posttranslational modification]
435590001047	intermolecular recognition site; other site
435590001048	dimerization interface [polypeptide binding]; other site
435590001049	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590001050	Walker A motif; other site
435590001051	ATP binding site [chemical binding]; other site
435590001052	Walker B motif; other site
435590001053	arginine finger; other site
435590001054	Helix-turn-helix domains; Region: HTH; cl00088
435590001055	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
435590001056	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
435590001057	active site
435590001058	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
435590001059	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
435590001060	NAD(P) binding site [chemical binding]; other site
435590001061	homotetramer interface [polypeptide binding]; other site
435590001062	homodimer interface [polypeptide binding]; other site
435590001063	active site
435590001064	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
435590001065	Helix-turn-helix domains; Region: HTH; cl00088
435590001066	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590001067	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590001068	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590001069	DNA binding residues [nucleotide binding]
435590001070	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
435590001071	FecR protein; Region: FecR; pfam04773
435590001072	Secretin and TonB N terminus short domain; Region: STN; cl06624
435590001073	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590001074	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590001075	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590001076	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590001077	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
435590001078	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590001079	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
435590001080	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
435590001081	Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565
435590001082	putative active site [active]
435590001083	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
435590001084	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590001085	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
435590001086	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
435590001087	Sulfatase; Region: Sulfatase; cl10460
435590001088	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
435590001089	putative dimer interface [polypeptide binding]; other site
435590001090	[2Fe-2S] cluster binding site [ion binding]; other site
435590001091	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
435590001092	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
435590001093	ATP binding site [chemical binding]; other site
435590001094	Mg++ binding site [ion binding]; other site
435590001095	motif III; other site
435590001096	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590001097	nucleotide binding region [chemical binding]; other site
435590001098	ATP-binding site [chemical binding]; other site
435590001099	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
435590001100	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
435590001101	active site
435590001102	metal binding site [ion binding]; metal-binding site
435590001103	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
435590001104	PQQ-like domain; Region: PQQ_2; pfam13360
435590001105	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
435590001106	active site
435590001107	Trp docking motif [polypeptide binding]; other site
435590001108	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
435590001109	putative catalytic site [active]
435590001110	putative metal binding site [ion binding]; other site
435590001111	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
435590001112	putative catalytic site [active]
435590001113	putative phosphate binding site [ion binding]; other site
435590001114	putative phosphate binding site [ion binding]; other site
435590001115	putative metal binding site [ion binding]; other site
435590001116	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
435590001117	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
435590001118	dimer interface [polypeptide binding]; other site
435590001119	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590001120	catalytic residue [active]
435590001121	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
435590001122	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
435590001123	Ligand Binding Site [chemical binding]; other site
435590001124	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
435590001125	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
435590001126	DNA binding residues [nucleotide binding]
435590001127	dimerization interface [polypeptide binding]; other site
435590001128	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
435590001129	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
435590001130	active site
435590001131	HIGH motif; other site
435590001132	dimer interface [polypeptide binding]; other site
435590001133	KMSKS motif; other site
435590001134	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
435590001135	carbamoyl-phosphate synthase, large subunit; Region: CPSaseII_lrg; TIGR01369
435590001136	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
435590001137	ATP-grasp domain; Region: ATP-grasp_4; cl03087
435590001138	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
435590001139	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
435590001140	ATP-grasp domain; Region: ATP-grasp_4; cl03087
435590001141	Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain; Region: MGS_CPS_I_III; cd01423
435590001142	probable substrate binding site [chemical binding]; other site
435590001143	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590001144	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590001145	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
435590001146	catalytic residues [active]
435590001147	Protein of unknown function (DUF328); Region: DUF328; cl01143
435590001148	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
435590001149	ligand binding site [chemical binding]; other site
435590001150	Sulfotransferase family; Region: Sulfotransfer_3; cl14559
435590001151	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
435590001152	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
435590001153	CysD dimerization site [polypeptide binding]; other site
435590001154	G1 box; other site
435590001155	putative GEF interaction site [polypeptide binding]; other site
435590001156	GTP/Mg2+ binding site [chemical binding]; other site
435590001157	Switch I region; other site
435590001158	G2 box; other site
435590001159	G3 box; other site
435590001160	Switch II region; other site
435590001161	G4 box; other site
435590001162	G5 box; other site
435590001163	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
435590001164	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
435590001165	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
435590001166	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
435590001167	Active Sites [active]
435590001168	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027
435590001169	AAA domain; Region: AAA_33; pfam13671
435590001170	ligand-binding site [chemical binding]; other site
435590001171	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
435590001172	transmembrane helices; other site
435590001173	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
435590001174	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638
435590001175	active site
435590001176	Surface antigen; Region: Bac_surface_Ag; cl03097
435590001177	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
435590001178	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590001179	ATP binding site [chemical binding]; other site
435590001180	Mg2+ binding site [ion binding]; other site
435590001181	G-X-G motif; other site
435590001182	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
435590001183	ATP binding site [chemical binding]; other site
435590001184	MutL C terminal dimerisation domain; Region: MutL_C; cl07336
435590001185	OstA-like protein; Region: OstA_2; pfam13100
435590001186	OstA-like protein; Region: OstA_2; pfam13100
435590001187	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
435590001188	PPIC-type PPIASE domain; Region: Rotamase; cl08278
435590001189	PPIC-type PPIASE domain; Region: Rotamase; cl08278
435590001190	PPIC-type PPIASE domain; Region: Rotamase; cl08278
435590001191	PPIC-type PPIASE domain; Region: Rotamase; cl08278
435590001192	peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095
435590001193	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
435590001194	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
435590001195	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601
435590001196	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381
435590001197	active site
435590001198	Virulence-associated protein E; Region: VirE; pfam05272
435590001199	Domain of unknonw function from B. Theta Gene description (DUF3874); Region: DUF3874; pfam12990
435590001200	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
435590001201	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
435590001202	catalytic residues [active]
435590001203	catalytic nucleophile [active]
435590001204	Presynaptic Site I dimer interface [polypeptide binding]; other site
435590001205	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
435590001206	Synaptic Flat tetramer interface [polypeptide binding]; other site
435590001207	Synaptic Site I dimer interface [polypeptide binding]; other site
435590001208	DNA binding site [nucleotide binding]
435590001209	Recombinase; Region: Recombinase; pfam07508
435590001210	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
435590001211	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
435590001212	Helix-turn-helix domains; Region: HTH; cl00088
435590001213	Domain of unknown function, B. Theta Gene description (DUF3871); Region: DUF3871; pfam12987
435590001214	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590001215	DNA binding site [nucleotide binding]
435590001216	Int/Topo IB signature motif; other site
435590001217	active site
435590001218	VirE N-terminal domain; Region: VirE_N; pfam08800
435590001219	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
435590001220	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590001221	ATP binding site [chemical binding]; other site
435590001222	putative Mg++ binding site [ion binding]; other site
435590001223	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590001224	nucleotide binding region [chemical binding]; other site
435590001225	ATP-binding site [chemical binding]; other site
435590001226	RQC domain; Region: RQC; cl09632
435590001227	HRDC domain; Region: HRDC; cl02578
435590001228	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
435590001229	ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964
435590001230	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590001231	Walker A motif; other site
435590001232	ATP binding site [chemical binding]; other site
435590001233	Walker B motif; other site
435590001234	arginine finger; other site
435590001235	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
435590001236	Clp protease; Region: CLP_protease; pfam00574
435590001237	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
435590001238	oligomer interface [polypeptide binding]; other site
435590001239	active site residues [active]
435590001240	trigger factor; Region: tig; TIGR00115
435590001241	RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590
435590001242	RNA/DNA binding site [nucleotide binding]; other site
435590001243	RRM dimerization site [polypeptide binding]; other site
435590001244	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
435590001245	The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218
435590001246	Walker A/P-loop; other site
435590001247	ATP binding site [chemical binding]; other site
435590001248	Q-loop/lid; other site
435590001249	ABC transporter signature motif; other site
435590001250	Walker B; other site
435590001251	D-loop; other site
435590001252	H-loop/switch region; other site
435590001253	Permease; Region: Permease; cl00510
435590001254	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
435590001255	ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261
435590001256	Walker A/P-loop; other site
435590001257	ATP binding site [chemical binding]; other site
435590001258	Q-loop/lid; other site
435590001259	ABC transporter signature motif; other site
435590001260	Walker B; other site
435590001261	D-loop; other site
435590001262	H-loop/switch region; other site
435590001263	GTP-binding protein Der; Reviewed; Region: PRK00093
435590001264	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
435590001265	G1 box; other site
435590001266	GTP/Mg2+ binding site [chemical binding]; other site
435590001267	Switch I region; other site
435590001268	G2 box; other site
435590001269	Switch II region; other site
435590001270	G3 box; other site
435590001271	G4 box; other site
435590001272	G5 box; other site
435590001273	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
435590001274	G1 box; other site
435590001275	GTP/Mg2+ binding site [chemical binding]; other site
435590001276	Switch I region; other site
435590001277	G2 box; other site
435590001278	G3 box; other site
435590001279	Switch II region; other site
435590001280	G4 box; other site
435590001281	G5 box; other site
435590001282	GTPase Era; Reviewed; Region: era; PRK00089
435590001283	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
435590001284	G1 box; other site
435590001285	GTP/Mg2+ binding site [chemical binding]; other site
435590001286	Switch I region; other site
435590001287	G2 box; other site
435590001288	Switch II region; other site
435590001289	G3 box; other site
435590001290	G4 box; other site
435590001291	G5 box; other site
435590001292	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
435590001293	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
435590001294	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
435590001295	dimer interface [polypeptide binding]; other site
435590001296	active site
435590001297	CoA binding pocket [chemical binding]; other site
435590001298	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
435590001299	Helix-turn-helix domains; Region: HTH; cl00088
435590001300	Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039
435590001301	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590001302	NAD(P) binding site [chemical binding]; other site
435590001303	LDH/MDH dimer interface [polypeptide binding]; other site
435590001304	substrate binding site [chemical binding]; other site
435590001305	DNA primase, catalytic core; Region: dnaG; TIGR01391
435590001306	CHC2 zinc finger; Region: zf-CHC2; cl15369
435590001307	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
435590001308	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
435590001309	active site
435590001310	metal binding site [ion binding]; metal-binding site
435590001311	interdomain interaction site; other site
435590001312	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
435590001313	homodecamer interface [polypeptide binding]; other site
435590001314	GTP cyclohydrolase I; Provisional; Region: PLN03044
435590001315	active site
435590001316	putative catalytic site residues [active]
435590001317	zinc binding site [ion binding]; other site
435590001318	GTP-CH-I/GFRP interaction surface; other site
435590001319	Sporulation related domain; Region: SPOR; cl10051
435590001320	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
435590001321	substrate binding site [chemical binding]; other site
435590001322	dimer interface [polypeptide binding]; other site
435590001323	catalytic triad [active]
435590001324	DoxX; Region: DoxX; cl00976
435590001325	Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659
435590001326	Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659
435590001327	Peptidase family M23; Region: Peptidase_M23; pfam01551
435590001328	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
435590001329	putative peptidoglycan binding site; other site
435590001330	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
435590001331	active site
435590001332	multimer interface [polypeptide binding]; other site
435590001333	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
435590001334	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
435590001335	generic binding surface II; other site
435590001336	ssDNA binding site; other site
435590001337	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590001338	ATP binding site [chemical binding]; other site
435590001339	putative Mg++ binding site [ion binding]; other site
435590001340	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590001341	nucleotide binding region [chemical binding]; other site
435590001342	ATP-binding site [chemical binding]; other site
435590001343	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
435590001344	substrate binding site; other site
435590001345	dimer interface; other site
435590001346	DJ-1 family protein; Region: not_thiJ; TIGR01383
435590001347	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
435590001348	conserved cys residue [active]
435590001349	Gram-negative bacterial tonB protein; Region: TonB; cl10048
435590001350	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
435590001351	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
435590001352	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003
435590001353	active site
435590001354	hydrophilic channel; other site
435590001355	dimerization interface [polypeptide binding]; other site
435590001356	catalytic residues [active]
435590001357	active site lid [active]
435590001358	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
435590001359	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
435590001360	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
435590001361	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
435590001362	Integrase core domain; Region: rve; cl01316
435590001363	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
435590001364	exonuclease subunit SbcC; Provisional; Region: PRK10246
435590001365	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590001366	Walker A/P-loop; other site
435590001367	ATP binding site [chemical binding]; other site
435590001368	Q-loop/lid; other site
435590001369	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590001370	ABC transporter signature motif; other site
435590001371	Walker B; other site
435590001372	D-loop; other site
435590001373	H-loop/switch region; other site
435590001374	exonuclease subunit SbcD; Provisional; Region: PRK10966
435590001375	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
435590001376	active site
435590001377	metal binding site [ion binding]; metal-binding site
435590001378	DNA binding site [nucleotide binding]
435590001379	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
435590001380	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
435590001381	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
435590001382	putative alpha-glucosidase; Provisional; Region: PRK10658
435590001383	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
435590001384	XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591
435590001385	putative active site [active]
435590001386	putative catalytic site [active]
435590001387	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590001388	SusD family; Region: SusD; pfam07980
435590001389	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590001390	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590001391	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590001392	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590001393	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590001394	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590001395	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590001396	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590001397	Beta-galactosidase; Region: Glyco_hydro_42; cl03154
435590001398	beta-galactosidase; Provisional; Region: PLN03059
435590001399	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
435590001400	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
435590001401	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
435590001402	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412
435590001403	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
435590001404	active site
435590001405	Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004
435590001406	putative substrate binding site [chemical binding]; other site
435590001407	active site
435590001408	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
435590001409	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590001410	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590001411	Secretin and TonB N terminus short domain; Region: STN; cl06624
435590001412	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590001413	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590001414	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590001415	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
435590001416	FecR protein; Region: FecR; pfam04773
435590001417	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590001418	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590001419	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590001420	DNA binding residues [nucleotide binding]
435590001421	PIF1-like helicase; Region: PIF1; pfam05970
435590001422	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590001423	Walker A motif; other site
435590001424	ATP binding site [chemical binding]; other site
435590001425	Walker B motif; other site
435590001426	Family description; Region: UvrD_C_2; cl15862
435590001427	HRDC domain; Region: HRDC; cl02578
435590001428	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590001429	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590001430	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590001431	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590001432	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590001433	Glycosyl hydrolase family 43; Region: GH43_2; cd08981
435590001434	active site
435590001435	Glycosyl hydrolase family 43; Region: GH43_6; cd08985
435590001436	active site
435590001437	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
435590001438	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_3; cd09002
435590001439	active site
435590001440	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
435590001441	active site
435590001442	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590001443	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590001444	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590001445	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590001446	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590001447	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590001448	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590001449	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590001450	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590001451	dimer interface [polypeptide binding]; other site
435590001452	phosphorylation site [posttranslational modification]
435590001453	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590001454	ATP binding site [chemical binding]; other site
435590001455	Mg2+ binding site [ion binding]; other site
435590001456	G-X-G motif; other site
435590001457	Response regulator receiver domain; Region: Response_reg; pfam00072
435590001458	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590001459	active site
435590001460	phosphorylation site [posttranslational modification]
435590001461	intermolecular recognition site; other site
435590001462	dimerization interface [polypeptide binding]; other site
435590001463	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
435590001464	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590001465	Protein of unknown function (DUF3810); Region: DUF3810; pfam12725
435590001466	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
435590001467	Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752
435590001468	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
435590001469	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
435590001470	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
435590001471	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
435590001472	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
435590001473	dihydropteroate synthase; Region: DHPS; TIGR01496
435590001474	substrate binding pocket [chemical binding]; other site
435590001475	dimer interface [polypeptide binding]; other site
435590001476	inhibitor binding site; inhibition site
435590001477	Uncharacterized conserved protein [Function unknown]; Region: COG1624
435590001478	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
435590001479	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
435590001480	Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552
435590001481	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
435590001482	LrgB-like family; Region: LrgB; cl00596
435590001483	LrgA family; Region: LrgA; cl00608
435590001484	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
435590001485	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
435590001486	Acetokinase family; Region: Acetate_kinase; cl01029
435590001487	propionate/acetate kinase; Provisional; Region: PRK12379
435590001488	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
435590001489	putative active site [active]
435590001490	putative metal binding site [ion binding]; other site
435590001491	Domain of unknown function DUF59; Region: DUF59; cl00941
435590001492	hypothetical protein; Reviewed; Region: PRK00024
435590001493	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
435590001494	MPN+ (JAMM) motif; other site
435590001495	Zinc-binding site [ion binding]; other site
435590001496	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
435590001497	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
435590001498	active site
435590001499	elongation factor P; Validated; Region: PRK00529
435590001500	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
435590001501	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
435590001502	RNA binding site [nucleotide binding]; other site
435590001503	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
435590001504	RNA binding site [nucleotide binding]; other site
435590001505	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
435590001506	anaerobic sulfatase-maturase; Provisional; Region: PRK13745
435590001507	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590001508	FeS/SAM binding site; other site
435590001509	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
435590001510	Phosphate-selective porin O and P; Region: Porin_O_P; cl01524
435590001511	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
435590001512	active site
435590001513	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
435590001514	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
435590001515	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
435590001516	sugar binding site [chemical binding]; other site
435590001517	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
435590001518	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
435590001519	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590001520	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
435590001521	Beta galactosidase small chain; Region: Bgal_small_N; cl03787
435590001522	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
435590001523	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
435590001524	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
435590001525	active site
435590001526	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
435590001527	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
435590001528	Sulfatase; Region: Sulfatase; cl10460
435590001529	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
435590001530	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590001531	SusD family; Region: SusD; pfam07980
435590001532	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590001533	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590001534	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590001535	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590001536	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
435590001537	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
435590001538	sialate O-acetylesterase_like family of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like1; cd01827
435590001539	active site
435590001540	catalytic triad [active]
435590001541	oxyanion hole [active]
435590001542	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590001543	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590001544	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590001545	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590001546	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590001547	dimer interface [polypeptide binding]; other site
435590001548	phosphorylation site [posttranslational modification]
435590001549	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590001550	ATP binding site [chemical binding]; other site
435590001551	G-X-G motif; other site
435590001552	Response regulator receiver domain; Region: Response_reg; pfam00072
435590001553	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590001554	active site
435590001555	phosphorylation site [posttranslational modification]
435590001556	intermolecular recognition site; other site
435590001557	dimerization interface [polypeptide binding]; other site
435590001558	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590001559	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590001560	RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590
435590001561	RNA/DNA binding site [nucleotide binding]; other site
435590001562	RRM dimerization site [polypeptide binding]; other site
435590001563	Protein of unknown function (DUF1212); Region: DUF1212; cl01118
435590001564	Protein of unknown function (DUF1212); Region: DUF1212; cl01118
435590001565	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
435590001566	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
435590001567	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
435590001568	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
435590001569	RNA binding surface [nucleotide binding]; other site
435590001570	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
435590001571	active site
435590001572	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
435590001573	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
435590001574	ATP-grasp domain; Region: ATP-grasp_4; cl03087
435590001575	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
435590001576	putative acyl-acceptor binding pocket; other site
435590001577	NigD-like protein; Region: NigD; pfam12667
435590001578	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
435590001579	active site residue [active]
435590001580	N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523
435590001581	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
435590001582	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590001583	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
435590001584	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
435590001585	putative catalytic cysteine [active]
435590001586	gamma-glutamyl kinase; Provisional; Region: PRK05429
435590001587	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
435590001588	nucleotide binding site [chemical binding]; other site
435590001589	homotetrameric interface [polypeptide binding]; other site
435590001590	putative phosphate binding site [ion binding]; other site
435590001591	putative allosteric binding site; other site
435590001592	PUA domain; Region: PUA; cl00607
435590001593	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
435590001594	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
435590001595	active site
435590001596	motif I; other site
435590001597	motif II; other site
435590001598	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
435590001599	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
435590001600	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; cl15460
435590001601	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
435590001602	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
435590001603	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
435590001604	Fibronectin type III-like domain; Region: Fn3-like; cl15273
435590001605	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
435590001606	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590001607	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590001608	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590001609	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590001610	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590001611	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590001612	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590001613	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590001614	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590001615	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590001616	Peptide-N-glycosidase F, N terminal; Region: N-glycanase_N; pfam09112
435590001617	Peptide-N-glycosidase F, C terminal; Region: N-glycanase_C; pfam09113
435590001618	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
435590001619	IHF - DNA interface [nucleotide binding]; other site
435590001620	IHF dimer interface [polypeptide binding]; other site
435590001621	Virulence-associated protein E; Region: VirE; pfam05272
435590001622	Domain of unknonw function from B. Theta Gene description (DUF3874); Region: DUF3874; pfam12990
435590001623	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590001624	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590001625	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590001626	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590001627	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590001628	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
435590001629	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590001630	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590001631	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590001632	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590001633	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590001634	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
435590001635	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590001636	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590001637	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
435590001638	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
435590001639	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
435590001640	AMP-binding enzyme; Region: AMP-binding; cl15778
435590001641	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
435590001642	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
435590001643	non-specific DNA binding site [nucleotide binding]; other site
435590001644	salt bridge; other site
435590001645	sequence-specific DNA binding site [nucleotide binding]; other site
435590001646	Cupin domain; Region: Cupin_2; cl09118
435590001647	Domain of unknown function (DUF1893); Region: TM1506; pfam08973
435590001648	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
435590001649	4Fe-4S binding domain; Region: Fer4_5; pfam12801
435590001650	4Fe-4S binding domain; Region: Fer4_5; pfam12801
435590001651	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
435590001652	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
435590001653	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
435590001654	Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143
435590001655	4Fe-4S binding domain; Region: Fer4; cl02805
435590001656	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
435590001657	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
435590001658	active site
435590001659	catalytic tetrad [active]
435590001660	Sodium:solute symporter family; Region: SSF; cl00456
435590001661	Sulfatase; Region: Sulfatase; cl10460
435590001662	Sulfatase; Region: Sulfatase; cl10460
435590001663	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
435590001664	active site
435590001665	Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935
435590001666	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590001667	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590001668	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590001669	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590001670	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590001671	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
435590001672	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
435590001673	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590001674	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590001675	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590001676	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
435590001677	acetylornithine aminotransferase; Provisional; Region: PRK02627
435590001678	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
435590001679	inhibitor-cofactor binding pocket; inhibition site
435590001680	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590001681	catalytic residue [active]
435590001682	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
435590001683	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590001684	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
435590001685	Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137
435590001686	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
435590001687	ANP binding site [chemical binding]; other site
435590001688	Substrate Binding Site II [chemical binding]; other site
435590001689	Substrate Binding Site I [chemical binding]; other site
435590001690	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
435590001691	Arginine repressor [Transcription]; Region: ArgR; COG1438
435590001692	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
435590001693	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
435590001694	L-rhamnulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
435590001695	N- and C-terminal domain interface [polypeptide binding]; other site
435590001696	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
435590001697	active site
435590001698	catalytic site [active]
435590001699	metal binding site [ion binding]; metal-binding site
435590001700	ATP binding site [chemical binding]; other site
435590001701	carbohydrate binding site [chemical binding]; other site
435590001702	L-rhamnose isomerase; Provisional; Region: PRK01076
435590001703	L-rhamnose isomerase (RhaA); Region: RhaA; cl09945
435590001704	L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728
435590001705	RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776
435590001706	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
435590001707	intersubunit interface [polypeptide binding]; other site
435590001708	active site
435590001709	Zn2+ binding site [ion binding]; other site
435590001710	Domain of unknown function (DUF4251); Region: DUF4251; pfam14059
435590001711	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590001712	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590001713	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590001714	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590001715	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590001716	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590001717	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590001718	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590001719	dimer interface [polypeptide binding]; other site
435590001720	phosphorylation site [posttranslational modification]
435590001721	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590001722	ATP binding site [chemical binding]; other site
435590001723	Mg2+ binding site [ion binding]; other site
435590001724	G-X-G motif; other site
435590001725	Response regulator receiver domain; Region: Response_reg; pfam00072
435590001726	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590001727	active site
435590001728	phosphorylation site [posttranslational modification]
435590001729	intermolecular recognition site; other site
435590001730	dimerization interface [polypeptide binding]; other site
435590001731	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590001732	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590001733	Cupin domain; Region: Cupin_2; cl09118
435590001734	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590001735	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590001736	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590001737	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
435590001738	N-acetyl-D-glucosamine binding site [chemical binding]; other site
435590001739	catalytic residue [active]
435590001740	Ion transport protein; Region: Ion_trans; pfam00520
435590001741	Ion channel; Region: Ion_trans_2; cl11596
435590001742	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
435590001743	beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525
435590001744	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
435590001745	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590001746	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
435590001747	Beta galactosidase small chain; Region: Bgal_small_N; cl03787
435590001748	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590001749	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590001750	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590001751	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590001752	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
435590001753	FecR protein; Region: FecR; pfam04773
435590001754	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
435590001755	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
435590001756	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590001757	Domain of unknown function (DUF377); Region: DUF377; pfam04041
435590001758	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
435590001759	active site
435590001760	AmpG-related permease; Region: 2A0125; TIGR00901
435590001761	muropeptide transporter; Validated; Region: ampG; PRK11010
435590001762	Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648
435590001763	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
435590001764	Domain of unknown function (DUF1735); Region: DUF1735; pfam08522
435590001765	Domain of unknown function (DUF1735); Region: DUF1735; pfam08522
435590001766	Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102
435590001767	Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542
435590001768	active site
435590001769	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
435590001770	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590001771	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590001772	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590001773	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590001774	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590001775	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
435590001776	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
435590001777	putative catalytic site [active]
435590001778	putative metal binding site [ion binding]; other site
435590001779	putative phosphate binding site [ion binding]; other site
435590001780	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
435590001781	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590001782	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590001783	Secretin and TonB N terminus short domain; Region: STN; cl06624
435590001784	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590001785	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590001786	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590001787	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
435590001788	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; cl15460
435590001789	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; cl15460
435590001790	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
435590001791	FecR protein; Region: FecR; pfam04773
435590001792	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590001793	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590001794	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590001795	DNA binding residues [nucleotide binding]
435590001796	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
435590001797	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; cl15460
435590001798	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590001799	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
435590001800	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
435590001801	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
435590001802	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
435590001803	Clp amino terminal domain; Region: Clp_N; pfam02861
435590001804	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590001805	Walker A motif; other site
435590001806	ATP binding site [chemical binding]; other site
435590001807	Walker B motif; other site
435590001808	arginine finger; other site
435590001809	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590001810	Walker A motif; other site
435590001811	ATP binding site [chemical binding]; other site
435590001812	Walker B motif; other site
435590001813	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
435590001814	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
435590001815	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
435590001816	MatE; Region: MatE; cl10513
435590001817	MatE; Region: MatE; cl10513
435590001818	PAS fold; Region: PAS_3; pfam08447
435590001819	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
435590001820	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
435590001821	DNA binding residues [nucleotide binding]
435590001822	dimerization interface [polypeptide binding]; other site
435590001823	alpha-galactosidase; Region: PLN02229
435590001824	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
435590001825	Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081
435590001826	Ca binding site [ion binding]; other site
435590001827	Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185
435590001828	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
435590001829	Int/Topo IB signature motif; other site
435590001830	Domain of unknown function (DUF4120); Region: DUF4120; pfam13496
435590001831	Domain of unknown function (DUF4121); Region: DUF4121; pfam13497
435590001832	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
435590001833	peptidase T-like protein; Region: PepT-like; TIGR01883
435590001834	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
435590001835	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
435590001836	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
435590001837	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
435590001838	catalytic residue [active]
435590001839	Domain of unknown function, B. Theta Gene description (DUF3872); Region: DUF3872; pfam12988
435590001840	Conjugative transposon protein TraO; Region: TraO; pfam10626
435590001841	Bacteroides conjugative transposon TraN protein; Region: Bac_Flav_CT_N; TIGR03780
435590001842	Domain of unknown function (DUF4138); Region: DUF4138; pfam13595
435590001843	Bacteroides conjugative transposon TraM protein; Region: Bac_Flav_CT_M; TIGR03779
435590001844	Protein of unknown function (DUF3714); Region: DUF3714; pfam12508
435590001845	Protein of unknown function (DUF3989); Region: DUF3989; pfam13150
435590001846	Bacteroides conjugative transposon TraK protein; Region: Bac_Flav_CT_K; TIGR03781
435590001847	Bacteroides conjugative transposon TraJ protein; Region: Bac_Flav_CT_J; TIGR03782
435590001848	Domain of unknown function (DUF4141); Region: DUF4141; pfam13605
435590001849	Domain of unknown function, B. Theta Gene description (DUF3876); Region: DUF3876; pfam12992
435590001850	Bacteroides conjugation system ATPase, TraG family; Region: Bac_Flav_CT_G; TIGR03783
435590001851	Domain of unknown function, B. Theta Gene description (DUF3875); Region: DUF3875; pfam12991
435590001852	Domain of unknown function (DUF4133); Region: DUF4133; pfam13571
435590001853	Protein of unknown function DUF262; Region: DUF262; cl14890
435590001854	Uncharacterized conserved protein [Function unknown]; Region: COG4938
435590001855	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590001856	Walker A/P-loop; other site
435590001857	ATP binding site [chemical binding]; other site
435590001858	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590001859	Walker B; other site
435590001860	D-loop; other site
435590001861	H-loop/switch region; other site
435590001862	Protein of unknown function (DUF3696); Region: DUF3696; pfam12476
435590001863	Domain of unknown function (DUF4122); Region: DUF4122; pfam13498
435590001864	Protein of unknown function (DUF3408); Region: DUF3408; pfam11888
435590001865	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
435590001866	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590001867	Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584
435590001868	YWFCY protein; Region: YWFCY; pfam14293
435590001869	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
435590001870	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590001871	Walker B motif; other site
435590001872	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
435590001873	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
435590001874	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590001875	active site
435590001876	phosphorylation site [posttranslational modification]
435590001877	intermolecular recognition site; other site
435590001878	dimerization interface [polypeptide binding]; other site
435590001879	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590001880	Walker A motif; other site
435590001881	ATP binding site [chemical binding]; other site
435590001882	Walker B motif; other site
435590001883	arginine finger; other site
435590001884	Helix-turn-helix domains; Region: HTH; cl00088
435590001885	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590001886	dimer interface [polypeptide binding]; other site
435590001887	phosphorylation site [posttranslational modification]
435590001888	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590001889	ATP binding site [chemical binding]; other site
435590001890	Mg2+ binding site [ion binding]; other site
435590001891	G-X-G motif; other site
435590001892	Response regulator receiver domain; Region: Response_reg; pfam00072
435590001893	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590001894	active site
435590001895	phosphorylation site [posttranslational modification]
435590001896	intermolecular recognition site; other site
435590001897	dimerization interface [polypeptide binding]; other site
435590001898	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590001899	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590001900	nucleotide binding region [chemical binding]; other site
435590001901	ATP-binding site [chemical binding]; other site
435590001902	Helicase associated domain; Region: HA; pfam03457
435590001903	Helicase associated domain; Region: HA; pfam03457
435590001904	Helicase associated domain; Region: HA; pfam03457
435590001905	Helicase associated domain; Region: HA; pfam03457
435590001906	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
435590001907	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
435590001908	active site
435590001909	homodimer interface [polypeptide binding]; other site
435590001910	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
435590001911	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
435590001912	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
435590001913	putative trimer interface [polypeptide binding]; other site
435590001914	putative CoA binding site [chemical binding]; other site
435590001915	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
435590001916	putative trimer interface [polypeptide binding]; other site
435590001917	putative CoA binding site [chemical binding]; other site
435590001918	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590001919	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
435590001920	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
435590001921	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
435590001922	active site
435590001923	homodimer interface [polypeptide binding]; other site
435590001924	Cupin domain; Region: Cupin_2; cl09118
435590001925	capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261
435590001926	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
435590001927	putative NAD(P) binding site [chemical binding]; other site
435590001928	active site
435590001929	putative substrate binding site [chemical binding]; other site
435590001930	Cupin domain; Region: Cupin_2; cl09118
435590001931	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
435590001932	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
435590001933	NAD(P) binding site [chemical binding]; other site
435590001934	homodimer interface [polypeptide binding]; other site
435590001935	substrate binding site [chemical binding]; other site
435590001936	active site
435590001937	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
435590001938	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590001939	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
435590001940	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
435590001941	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
435590001942	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
435590001943	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590001944	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
435590001945	Chain length determinant protein; Region: Wzz; cl15801
435590001946	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
435590001947	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
435590001948	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590001949	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
435590001950	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
435590001951	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
435590001952	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
435590001953	Mg++ binding site [ion binding]; other site
435590001954	putative catalytic motif [active]
435590001955	substrate binding site [chemical binding]; other site
435590001956	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
435590001957	KOW motif; Region: KOW; cl00354
435590001958	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590001959	DNA binding site [nucleotide binding]
435590001960	Int/Topo IB signature motif; other site
435590001961	active site
435590001962	Protein of unknown function (DUF4099); Region: DUF4099; pfam13351
435590001963	Protein of unknown function (DUF3945); Region: DUF3945; pfam13101
435590001964	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
435590001965	Protein of unknown function (DUF3945); Region: DUF3945; pfam13101
435590001966	Protein of unknown function (DUF3945); Region: DUF3945; pfam13101
435590001967	Protein of unknown function (DUF4099); Region: DUF4099; pfam13351
435590001968	DNA topoisomerase III; Provisional; Region: PRK07726
435590001969	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
435590001970	active site
435590001971	putative interdomain interaction site [polypeptide binding]; other site
435590001972	putative metal-binding site [ion binding]; other site
435590001973	putative nucleotide binding site [chemical binding]; other site
435590001974	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
435590001975	domain I; other site
435590001976	DNA binding groove [nucleotide binding]
435590001977	phosphate binding site [ion binding]; other site
435590001978	domain II; other site
435590001979	domain III; other site
435590001980	nucleotide binding site [chemical binding]; other site
435590001981	catalytic site [active]
435590001982	domain IV; other site
435590001983	PRTRC system protein E; Region: PRTRC_E; TIGR03741
435590001984	Prokaryotic Ubiquitin; Region: Prok_Ub; cl14020
435590001985	Prokaryotic E2 family D; Region: Prok-E2_D; cl14019
435590001986	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590001987	ATP binding site [chemical binding]; other site
435590001988	substrate interface [chemical binding]; other site
435590001989	LabA_like proteins; Region: LabA_like/DUF88; cl10034
435590001990	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
435590001991	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
435590001992	DNA binding residues [nucleotide binding]
435590001993	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
435590001994	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
435590001995	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
435590001996	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590001997	Restriction endonuclease; Region: Mrr_cat; cl00516
435590001998	AAA domain; Region: AAA_21; pfam13304
435590001999	RloB-like protein; Region: RloB; pfam13707
435590002000	DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358
435590002001	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
435590002002	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973
435590002003	Phosphate-selective porin O and P; Region: Porin_O_P; cl01524
435590002004	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
435590002005	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590002006	Secretin and TonB N terminus short domain; Region: STN; cl06624
435590002007	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590002008	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590002009	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590002010	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590002011	FecR protein; Region: FecR; pfam04773
435590002012	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590002013	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590002014	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590002015	DNA binding residues [nucleotide binding]
435590002016	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
435590002017	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
435590002018	Cupin domain; Region: Cupin_2; cl09118
435590002019	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590002020	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590002021	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590002022	Domain of unknown function (DUF303); Region: DUF303; pfam03629
435590002023	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
435590002024	Domain of unknown function (DUF303); Region: DUF303; pfam03629
435590002025	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590002026	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590002027	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590002028	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590002029	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590002030	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
435590002031	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
435590002032	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
435590002033	Fibronectin type III-like domain; Region: Fn3-like; cl15273
435590002034	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
435590002035	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
435590002036	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590002037	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
435590002038	Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231
435590002039	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
435590002040	sugar binding site [chemical binding]; other site
435590002041	Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017
435590002042	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
435590002043	active site
435590002044	catalytic residues [active]
435590002045	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590002046	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590002047	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590002048	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590002049	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590002050	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590002051	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
435590002052	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590002053	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590002054	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590002055	dimer interface [polypeptide binding]; other site
435590002056	phosphorylation site [posttranslational modification]
435590002057	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590002058	ATP binding site [chemical binding]; other site
435590002059	Mg2+ binding site [ion binding]; other site
435590002060	G-X-G motif; other site
435590002061	Response regulator receiver domain; Region: Response_reg; pfam00072
435590002062	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590002063	active site
435590002064	phosphorylation site [posttranslational modification]
435590002065	intermolecular recognition site; other site
435590002066	dimerization interface [polypeptide binding]; other site
435590002067	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590002068	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590002069	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590002070	TPR motif; other site
435590002071	binding surface
435590002072	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
435590002073	binding surface
435590002074	TPR motif; other site
435590002075	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
435590002076	binding surface
435590002077	TPR motif; other site
435590002078	TPR repeat; Region: TPR_11; pfam13414
435590002079	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590002080	binding surface
435590002081	TPR motif; other site
435590002082	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
435590002083	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
435590002084	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590002085	putative substrate translocation pore; other site
435590002086	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590002087	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; cl15460
435590002088	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
435590002089	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; cl15460
435590002090	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
435590002091	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; cl15460
435590002092	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590002093	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
435590002094	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590002095	Family description; Region: UvrD_C_2; cl15862
435590002096	C-terminal domain of Escherichia coli uncharacterized protein yjhR and similar proteins; Region: PLDc_yjhR_C_like; cd09118
435590002097	PLD-like domain; Region: PLDc_2; pfam13091
435590002098	putative active site [active]
435590002099	catalytic site [active]
435590002100	Predicted membrane protein [Function unknown]; Region: COG2311
435590002101	Protein of unknown function (DUF418); Region: DUF418; cl12135
435590002102	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590002103	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
435590002104	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185
435590002105	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
435590002106	putative active site [active]
435590002107	metal binding site [ion binding]; metal-binding site
435590002108	Creatinine amidohydrolase; Region: Creatininase; cl00618
435590002109	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590002110	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590002111	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590002112	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590002113	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590002114	Domain of unknown function (DUF4221); Region: DUF4221; pfam13970
435590002115	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
435590002116	active site
435590002117	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
435590002118	Transposase; Region: DDE_Tnp_ISL3; pfam01610
435590002119	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
435590002120	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
435590002121	homodimer interface [polypeptide binding]; other site
435590002122	substrate-cofactor binding pocket; other site
435590002123	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590002124	catalytic residue [active]
435590002125	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
435590002126	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590002127	NAD(P) binding site [chemical binding]; other site
435590002128	active site
435590002129	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
435590002130	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590002131	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590002132	DNA binding residues [nucleotide binding]
435590002133	Domain of unknown function (DUF4252); Region: DUF4252; pfam14060
435590002134	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249
435590002135	MutS-like homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess...; Region: ABC_MutS-like; cd03283
435590002136	Walker A/P-loop; other site
435590002137	ATP binding site [chemical binding]; other site
435590002138	Q-loop/lid; other site
435590002139	ABC transporter signature motif; other site
435590002140	Walker B; other site
435590002141	D-loop; other site
435590002142	H-loop/switch region; other site
435590002143	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
435590002144	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
435590002145	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
435590002146	alphaNTD - beta interaction site [polypeptide binding]; other site
435590002147	alphaNTD homodimer interface [polypeptide binding]; other site
435590002148	alphaNTD - beta' interaction site [polypeptide binding]; other site
435590002149	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
435590002150	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
435590002151	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
435590002152	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
435590002153	RNA binding surface [nucleotide binding]; other site
435590002154	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
435590002155	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
435590002156	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
435590002157	rRNA binding site [nucleotide binding]; other site
435590002158	predicted 30S ribosome binding site; other site
435590002159	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
435590002160	active site
435590002161	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
435590002162	SecY translocase; Region: SecY; pfam00344
435590002163	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
435590002164	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
435590002165	23S rRNA binding site [nucleotide binding]; other site
435590002166	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
435590002167	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
435590002168	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
435590002169	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
435590002170	5S rRNA interface [nucleotide binding]; other site
435590002171	L27 interface [polypeptide binding]; other site
435590002172	23S rRNA interface [nucleotide binding]; other site
435590002173	L5 interface [polypeptide binding]; other site
435590002174	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
435590002175	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
435590002176	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
435590002177	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
435590002178	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
435590002179	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
435590002180	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
435590002181	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
435590002182	KOW motif; Region: KOW; cl00354
435590002183	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
435590002184	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
435590002185	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
435590002186	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
435590002187	23S rRNA interface [nucleotide binding]; other site
435590002188	putative translocon interaction site; other site
435590002189	signal recognition particle (SRP54) interaction site; other site
435590002190	L23 interface [polypeptide binding]; other site
435590002191	trigger factor interaction site; other site
435590002192	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
435590002193	23S rRNA interface [nucleotide binding]; other site
435590002194	5S rRNA interface [nucleotide binding]; other site
435590002195	putative antibiotic binding site [chemical binding]; other site
435590002196	L25 interface [polypeptide binding]; other site
435590002197	L27 interface [polypeptide binding]; other site
435590002198	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
435590002199	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
435590002200	G-X-X-G motif; other site
435590002201	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
435590002202	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
435590002203	putative translocon binding site; other site
435590002204	protein-rRNA interface [nucleotide binding]; other site
435590002205	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
435590002206	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
435590002207	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
435590002208	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
435590002209	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
435590002210	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
435590002211	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
435590002212	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
435590002213	elongation factor G; Reviewed; Region: PRK12739
435590002214	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
435590002215	G1 box; other site
435590002216	putative GEF interaction site [polypeptide binding]; other site
435590002217	GTP/Mg2+ binding site [chemical binding]; other site
435590002218	Switch I region; other site
435590002219	G2 box; other site
435590002220	G3 box; other site
435590002221	Switch II region; other site
435590002222	G4 box; other site
435590002223	G5 box; other site
435590002224	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
435590002225	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
435590002226	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
435590002227	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
435590002228	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
435590002229	S17 interaction site [polypeptide binding]; other site
435590002230	S8 interaction site; other site
435590002231	16S rRNA interaction site [nucleotide binding]; other site
435590002232	streptomycin interaction site [chemical binding]; other site
435590002233	23S rRNA interaction site [nucleotide binding]; other site
435590002234	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
435590002235	Protein of unknown function (DUF3467); Region: DUF3467; pfam11950
435590002236	Transposase domain (DUF772); Region: DUF772; cl15789
435590002237	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590002238	Transposase domain (DUF772); Region: DUF772; cl15789
435590002239	DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625
435590002240	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
435590002241	RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
435590002242	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
435590002243	DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597
435590002244	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
435590002245	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
435590002246	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
435590002247	bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603
435590002248	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
435590002249	DNA binding site [nucleotide binding]
435590002250	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
435590002251	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
435590002252	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
435590002253	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
435590002254	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
435590002255	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
435590002256	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
435590002257	RPB11 interaction site [polypeptide binding]; other site
435590002258	RPB12 interaction site [polypeptide binding]; other site
435590002259	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
435590002260	RPB3 interaction site [polypeptide binding]; other site
435590002261	RPB1 interaction site [polypeptide binding]; other site
435590002262	RPB11 interaction site [polypeptide binding]; other site
435590002263	RPB10 interaction site [polypeptide binding]; other site
435590002264	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
435590002265	core dimer interface [polypeptide binding]; other site
435590002266	peripheral dimer interface [polypeptide binding]; other site
435590002267	L10 interface [polypeptide binding]; other site
435590002268	L11 interface [polypeptide binding]; other site
435590002269	putative EF-Tu interaction site [polypeptide binding]; other site
435590002270	putative EF-G interaction site [polypeptide binding]; other site
435590002271	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
435590002272	23S rRNA interface [nucleotide binding]; other site
435590002273	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
435590002274	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
435590002275	mRNA/rRNA interface [nucleotide binding]; other site
435590002276	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
435590002277	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
435590002278	23S rRNA interface [nucleotide binding]; other site
435590002279	L7/L12 interface [polypeptide binding]; other site
435590002280	putative thiostrepton binding site; other site
435590002281	L25 interface [polypeptide binding]; other site
435590002282	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
435590002283	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
435590002284	putative homodimer interface [polypeptide binding]; other site
435590002285	KOW motif; Region: KOW; cl00354
435590002286	elongation factor Tu; Reviewed; Region: PRK12735
435590002287	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
435590002288	G1 box; other site
435590002289	GEF interaction site [polypeptide binding]; other site
435590002290	GTP/Mg2+ binding site [chemical binding]; other site
435590002291	Switch I region; other site
435590002292	G2 box; other site
435590002293	G3 box; other site
435590002294	Switch II region; other site
435590002295	G4 box; other site
435590002296	G5 box; other site
435590002297	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
435590002298	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
435590002299	Antibiotic Binding Site [chemical binding]; other site
435590002300	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552
435590002301	30S subunit binding site; other site
435590002302	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
435590002303	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590002304	DNA binding site [nucleotide binding]
435590002305	Int/Topo IB signature motif; other site
435590002306	active site
435590002307	Ribosomal protein S21; Region: Ribosomal_S21; cl00529
435590002308	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
435590002309	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
435590002310	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
435590002311	active site
435590002312	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
435590002313	trimer interface [polypeptide binding]; other site
435590002314	putative metal binding site [ion binding]; other site
435590002315	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
435590002316	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
435590002317	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
435590002318	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
435590002319	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
435590002320	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590002321	active site
435590002322	phosphorylation site [posttranslational modification]
435590002323	intermolecular recognition site; other site
435590002324	dimerization interface [polypeptide binding]; other site
435590002325	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
435590002326	DNA binding site [nucleotide binding]
435590002327	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590002328	dimer interface [polypeptide binding]; other site
435590002329	phosphorylation site [posttranslational modification]
435590002330	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590002331	ATP binding site [chemical binding]; other site
435590002332	Mg2+ binding site [ion binding]; other site
435590002333	G-X-G motif; other site
435590002334	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590002335	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590002336	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
435590002337	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
435590002338	protein binding site [polypeptide binding]; other site
435590002339	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
435590002340	Catalytic dyad [active]
435590002341	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine...; Region: adenosine_kinase; cd01168
435590002342	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
435590002343	substrate binding site [chemical binding]; other site
435590002344	ATP binding site [chemical binding]; other site
435590002345	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590002346	Two component regulator propeller; Region: Reg_prop; pfam07494
435590002347	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590002348	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590002349	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590002350	dimer interface [polypeptide binding]; other site
435590002351	phosphorylation site [posttranslational modification]
435590002352	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590002353	ATP binding site [chemical binding]; other site
435590002354	Mg2+ binding site [ion binding]; other site
435590002355	G-X-G motif; other site
435590002356	Response regulator receiver domain; Region: Response_reg; pfam00072
435590002357	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590002358	active site
435590002359	phosphorylation site [posttranslational modification]
435590002360	intermolecular recognition site; other site
435590002361	dimerization interface [polypeptide binding]; other site
435590002362	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590002363	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590002364	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590002365	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590002366	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590002367	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590002368	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590002369	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
435590002370	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
435590002371	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
435590002372	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
435590002373	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
435590002374	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
435590002375	dimerization interface [polypeptide binding]; other site
435590002376	ligand binding site [chemical binding]; other site
435590002377	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
435590002378	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
435590002379	catalytic residue [active]
435590002380	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
435590002381	catalytic residues [active]
435590002382	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
435590002383	peroxiredoxin; Region: AhpC; TIGR03137
435590002384	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
435590002385	dimer interface [polypeptide binding]; other site
435590002386	decamer (pentamer of dimers) interface [polypeptide binding]; other site
435590002387	catalytic triad [active]
435590002388	peroxidatic and resolving cysteines [active]
435590002389	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
435590002390	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
435590002391	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
435590002392	PepSY-associated TM helix; Region: PepSY_TM_2; cl15813
435590002393	PepSY-associated TM helix; Region: PepSY_TM_2; cl15813
435590002394	Domain of unknown function (DUF4374); Region: DUF4374; pfam14298
435590002395	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590002396	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
435590002397	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
435590002398	N-terminal plug; other site
435590002399	ligand-binding site [chemical binding]; other site
435590002400	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
435590002401	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
435590002402	Transposase; Region: DDE_Tnp_ISL3; pfam01610
435590002403	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
435590002404	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
435590002405	active site
435590002406	catalytic tetrad [active]
435590002407	Lyase; Region: Lyase_1; pfam00206
435590002408	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
435590002409	active sites [active]
435590002410	tetramer interface [polypeptide binding]; other site
435590002411	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
435590002412	hydrophobic ligand binding site; other site
435590002413	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
435590002414	active site
435590002415	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
435590002416	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
435590002417	active site
435590002418	RecX family; Region: RecX; cl00936
435590002419	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
435590002420	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590002421	S-adenosylmethionine binding site [chemical binding]; other site
435590002422	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
435590002423	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
435590002424	catalytic motif [active]
435590002425	Zn binding site [ion binding]; other site
435590002426	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
435590002427	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
435590002428	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
435590002429	catalytic residue [active]
435590002430	putative FPP diphosphate  binding site; other site
435590002431	putative FPP binding hydrophobic cleft; other site
435590002432	dimer interface [polypeptide binding]; other site
435590002433	putative IPP diphosphate binding site; other site
435590002434	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
435590002435	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
435590002436	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
435590002437	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
435590002438	Surface antigen; Region: Bac_surface_Ag; cl03097
435590002439	Surface antigen; Region: Bac_surface_Ag; cl03097
435590002440	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
435590002441	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
435590002442	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
435590002443	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
435590002444	dimer interface [polypeptide binding]; other site
435590002445	pyridoxal binding site [chemical binding]; other site
435590002446	ATP binding site [chemical binding]; other site
435590002447	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
435590002448	FtsX-like permease family; Region: FtsX; cl15850
435590002449	Ribosome-binding factor A; Region: RBFA; cl00542
435590002450	O-methyltransferase; Region: Methyltransf_3; pfam01596
435590002451	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590002452	S-adenosylmethionine binding site [chemical binding]; other site
435590002453	pyruvate kinase; Provisional; Region: PRK05826
435590002454	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
435590002455	domain interfaces; other site
435590002456	active site
435590002457	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
435590002458	trimer interface [polypeptide binding]; other site
435590002459	active site
435590002460	dimer interface [polypeptide binding]; other site
435590002461	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
435590002462	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
435590002463	Int/Topo IB signature motif; other site
435590002464	active site
435590002465	Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010
435590002466	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590002467	TPR motif; other site
435590002468	binding surface
435590002469	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
435590002470	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
435590002471	catalytic residues [active]
435590002472	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
435590002473	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
435590002474	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590002475	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
435590002476	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
435590002477	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
435590002478	active site
435590002479	HIGH motif; other site
435590002480	KMSKS motif; other site
435590002481	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
435590002482	tRNA binding surface [nucleotide binding]; other site
435590002483	anticodon binding site; other site
435590002484	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
435590002485	dimer interface [polypeptide binding]; other site
435590002486	putative tRNA-binding site [nucleotide binding]; other site
435590002487	colanic acid exporter; Provisional; Region: PRK10459
435590002488	MatE; Region: MatE; cl10513
435590002489	Acyltransferase family; Region: Acyl_transf_3; pfam01757
435590002490	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
435590002491	active site
435590002492	metal-binding site
435590002493	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
435590002494	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
435590002495	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590002496	homodimer interface [polypeptide binding]; other site
435590002497	catalytic residue [active]
435590002498	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
435590002499	LicD family; Region: LicD; cl01378
435590002500	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
435590002501	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590002502	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
435590002503	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
435590002504	metal-binding site
435590002505	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
435590002506	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
435590002507	S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802
435590002508	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
435590002509	16S/18S rRNA binding site [nucleotide binding]; other site
435590002510	S13e-L30e interaction site [polypeptide binding]; other site
435590002511	25S rRNA binding site [nucleotide binding]; other site
435590002512	Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842
435590002513	Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842
435590002514	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
435590002515	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
435590002516	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
435590002517	Integrase core domain; Region: rve; cl01316
435590002518	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
435590002519	Domain of unknown function, B. Theta Gene description (DUF3868); Region: DUF3868; pfam12984
435590002520	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
435590002521	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590002522	TPR motif; other site
435590002523	TPR repeat; Region: TPR_11; pfam13414
435590002524	binding surface
435590002525	Protein of unknown function (DUF3575); Region: DUF3575; pfam12099
435590002526	Helix-turn-helix domains; Region: HTH; cl00088
435590002527	Domain of unknown function (DUF4373); Region: DUF4373; pfam14297
435590002528	Domain of unknown function (DUF4373); Region: DUF4373; pfam14297
435590002529	CHC2 zinc finger; Region: zf-CHC2; cl15369
435590002530	DNA primase; Validated; Region: dnaG; PRK05667
435590002531	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
435590002532	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
435590002533	Domain of unknown function (DUF3127); Region: DUF3127; pfam11325
435590002534	Protein of unknown function (DUF3575); Region: DUF3575; pfam12099
435590002535	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
435590002536	Protein of unknown function (DUF3988); Region: DUF3988; pfam13149
435590002537	Protein of unknown function (DUF3988); Region: DUF3988; pfam13149
435590002538	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
435590002539	Protein of unknown function (DUF3988); Region: DUF3988; pfam13149
435590002540	Bacteroides conjugation system ATPase, TraG family; Region: Bac_Flav_CT_G; TIGR03783
435590002541	Bacteroides conjugative transposon TraK protein; Region: Bac_Flav_CT_K; TIGR03781
435590002542	Protein of unknown function (DUF3714); Region: DUF3714; pfam12508
435590002543	TIR domain; Region: TIR_2; cl15770
435590002544	Domain of unknown function (DUF4138); Region: DUF4138; pfam13595
435590002545	Bacteroides conjugative transposon TraN protein; Region: Bac_Flav_CT_N; TIGR03780
435590002546	Domain of unknown function (DUF4138); Region: DUF4138; pfam13595
435590002547	Peptidase family M23; Region: Peptidase_M23; pfam01551
435590002548	Helix-turn-helix domains; Region: HTH; cl00088
435590002549	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590002550	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590002551	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
435590002552	FecR protein; Region: FecR; pfam04773
435590002553	Domain of unknown function (DUF3543); Region: DUF3543; pfam12063
435590002554	Secretin and TonB N terminus short domain; Region: STN; cl06624
435590002555	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590002556	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590002557	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590002558	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590002559	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590002560	Domain of unknown function (DUF1735); Region: DUF1735; pfam08522
435590002561	Domain of unknown function (DUF1735); Region: DUF1735; pfam08522
435590002562	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
435590002563	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
435590002564	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
435590002565	Peptidase M60-like family; Region: M60-like; pfam13402
435590002566	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
435590002567	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590002568	Protein of unknown function (DUF3988); Region: DUF3988; pfam13149
435590002569	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
435590002570	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
435590002571	P-loop; other site
435590002572	Magnesium ion binding site [ion binding]; other site
435590002573	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
435590002574	Magnesium ion binding site [ion binding]; other site
435590002575	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590002576	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590002577	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590002578	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590002579	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590002580	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590002581	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590002582	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590002583	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590002584	Walker A motif; other site
435590002585	ATP binding site [chemical binding]; other site
435590002586	Walker B motif; other site
435590002587	Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224
435590002588	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
435590002589	Helix-turn-helix domains; Region: HTH; cl00088
435590002590	putative Zn2+ binding site [ion binding]; other site
435590002591	putative DNA binding site [nucleotide binding]; other site
435590002592	Integrase core domain; Region: rve; cl01316
435590002593	transposase/IS protein; Provisional; Region: PRK09183
435590002594	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590002595	Walker A motif; other site
435590002596	ATP binding site [chemical binding]; other site
435590002597	Walker B motif; other site
435590002598	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590002599	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590002600	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590002601	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590002602	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590002603	ATP binding site [chemical binding]; other site
435590002604	Mg2+ binding site [ion binding]; other site
435590002605	G-X-G motif; other site
435590002606	Response regulator receiver domain; Region: Response_reg; pfam00072
435590002607	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590002608	active site
435590002609	phosphorylation site [posttranslational modification]
435590002610	intermolecular recognition site; other site
435590002611	dimerization interface [polypeptide binding]; other site
435590002612	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590002613	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
435590002614	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
435590002615	G1 box; other site
435590002616	putative GEF interaction site [polypeptide binding]; other site
435590002617	GTP/Mg2+ binding site [chemical binding]; other site
435590002618	Switch I region; other site
435590002619	G2 box; other site
435590002620	G3 box; other site
435590002621	Switch II region; other site
435590002622	G4 box; other site
435590002623	G5 box; other site
435590002624	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
435590002625	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
435590002626	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
435590002627	putative FMN binding site [chemical binding]; other site
435590002628	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
435590002629	active site
435590002630	substrate-binding site [chemical binding]; other site
435590002631	metal-binding site [ion binding]
435590002632	ATP binding site [chemical binding]; other site
435590002633	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
435590002634	active site
435590002635	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
435590002636	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
435590002637	TPP-binding site [chemical binding]; other site
435590002638	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
435590002639	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
435590002640	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
435590002641	dimer interface [polypeptide binding]; other site
435590002642	PYR/PP interface [polypeptide binding]; other site
435590002643	TPP binding site [chemical binding]; other site
435590002644	substrate binding site [chemical binding]; other site
435590002645	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
435590002646	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
435590002647	substrate-cofactor binding pocket; other site
435590002648	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590002649	catalytic residue [active]
435590002650	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
435590002651	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590002652	NAD(P) binding site [chemical binding]; other site
435590002653	active site
435590002654	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
435590002655	active site
435590002656	substrate-binding site [chemical binding]; other site
435590002657	metal-binding site [ion binding]
435590002658	ATP binding site [chemical binding]; other site
435590002659	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
435590002660	active site
435590002661	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
435590002662	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
435590002663	TPP-binding site [chemical binding]; other site
435590002664	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
435590002665	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
435590002666	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
435590002667	dimer interface [polypeptide binding]; other site
435590002668	PYR/PP interface [polypeptide binding]; other site
435590002669	TPP binding site [chemical binding]; other site
435590002670	substrate binding site [chemical binding]; other site
435590002671	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
435590002672	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
435590002673	substrate-cofactor binding pocket; other site
435590002674	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590002675	catalytic residue [active]
435590002676	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
435590002677	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590002678	NAD(P) binding site [chemical binding]; other site
435590002679	active site
435590002680	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
435590002681	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
435590002682	substrate binding site [chemical binding]; other site
435590002683	ATP binding site [chemical binding]; other site
435590002684	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
435590002685	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
435590002686	Protein export membrane protein; Region: SecD_SecF; cl14618
435590002687	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
435590002688	Protein export membrane protein; Region: SecD_SecF; cl14618
435590002689	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
435590002690	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
435590002691	active site
435590002692	Zn binding site [ion binding]; other site
435590002693	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084
435590002694	putative catalytic site [active]
435590002695	putative metal binding site [ion binding]; other site
435590002696	putative phosphate binding site [ion binding]; other site
435590002697	intramembrane serine protease GlpG; Provisional; Region: PRK10907
435590002698	Rhomboid family; Region: Rhomboid; cl11446
435590002699	Rhomboid family; Region: Rhomboid; cl11446
435590002700	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
435590002701	IHF dimer interface [polypeptide binding]; other site
435590002702	IHF - DNA interface [nucleotide binding]; other site
435590002703	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
435590002704	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
435590002705	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590002706	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
435590002707	Beta galactosidase small chain; Region: Bgal_small_N; cl03787
435590002708	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
435590002709	tRNA-specific 2-thiouridylase MnmA; Provisional; Region: mnmA; PRK14665
435590002710	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
435590002711	Ligand Binding Site [chemical binding]; other site
435590002712	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
435590002713	Sulfatase; Region: Sulfatase; cl10460
435590002714	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
435590002715	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
435590002716	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412
435590002717	Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998
435590002718	substrate binding site [chemical binding]; other site
435590002719	active site
435590002720	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590002721	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590002722	Two component regulator propeller; Region: Reg_prop; pfam07494
435590002723	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590002724	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
435590002725	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590002726	dimer interface [polypeptide binding]; other site
435590002727	phosphorylation site [posttranslational modification]
435590002728	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590002729	ATP binding site [chemical binding]; other site
435590002730	Mg2+ binding site [ion binding]; other site
435590002731	G-X-G motif; other site
435590002732	Response regulator receiver domain; Region: Response_reg; pfam00072
435590002733	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590002734	active site
435590002735	phosphorylation site [posttranslational modification]
435590002736	intermolecular recognition site; other site
435590002737	dimerization interface [polypeptide binding]; other site
435590002738	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590002739	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590002740	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
435590002741	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590002742	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590002743	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590002744	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590002745	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590002746	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590002747	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590002748	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
435590002749	active site
435590002750	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
435590002751	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
435590002752	active site
435590002753	HIGH motif; other site
435590002754	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
435590002755	KMSKS motif; other site
435590002756	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
435590002757	tRNA binding surface [nucleotide binding]; other site
435590002758	anticodon binding site; other site
435590002759	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
435590002760	active sites [active]
435590002761	tetramer interface [polypeptide binding]; other site
435590002762	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
435590002763	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
435590002764	NAD(P) binding site [chemical binding]; other site
435590002765	homotetramer interface [polypeptide binding]; other site
435590002766	homodimer interface [polypeptide binding]; other site
435590002767	active site
435590002768	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
435590002769	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
435590002770	dimer interface [polypeptide binding]; other site
435590002771	active site
435590002772	Phosphopantetheine attachment site; Region: PP-binding; cl09936
435590002773	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
435590002774	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
435590002775	putative acyl-acceptor binding pocket; other site
435590002776	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
435590002777	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
435590002778	active site 2 [active]
435590002779	active site 1 [active]
435590002780	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
435590002781	active site
435590002782	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
435590002783	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
435590002784	dimer interface [polypeptide binding]; other site
435590002785	active site
435590002786	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
435590002787	Phosphopantetheine attachment site; Region: PP-binding; cl09936
435590002788	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
435590002789	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
435590002790	dimer interface [polypeptide binding]; other site
435590002791	active site
435590002792	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
435590002793	active site
435590002794	KilA-N domain; Region: KilA-N; pfam04383
435590002795	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
435590002796	NodB motif; other site
435590002797	active site
435590002798	catalytic site [active]
435590002799	metal binding site [ion binding]; metal-binding site
435590002800	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065
435590002801	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
435590002802	active site 2 [active]
435590002803	active site 1 [active]
435590002804	Domain of unknown function (DUF4221); Region: DUF4221; pfam13970
435590002805	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
435590002806	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
435590002807	Ligand binding site; other site
435590002808	Putative Catalytic site; other site
435590002809	DXD motif; other site
435590002810	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261
435590002811	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
435590002812	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
435590002813	putative acyl-acceptor binding pocket; other site
435590002814	Methyltransferase domain; Region: Methyltransf_31; pfam13847
435590002815	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590002816	S-adenosylmethionine binding site [chemical binding]; other site
435590002817	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
435590002818	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590002819	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
435590002820	active site
435590002821	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
435590002822	AMP-binding enzyme; Region: AMP-binding; cl15778
435590002823	GAF domain; Region: GAF_2; pfam13185
435590002824	GAF domain; Region: GAF; cl15785
435590002825	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
435590002826	hypothetical protein; Provisional; Region: PRK13560
435590002827	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590002828	dimer interface [polypeptide binding]; other site
435590002829	phosphorylation site [posttranslational modification]
435590002830	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590002831	ATP binding site [chemical binding]; other site
435590002832	Mg2+ binding site [ion binding]; other site
435590002833	G-X-G motif; other site
435590002834	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
435590002835	Bacterial Ig-like domain; Region: Big_5; cl01012
435590002836	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590002837	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
435590002838	GH3 auxin-responsive promoter; Region: GH3; cl04006
435590002839	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
435590002840	active site
435590002841	ADP/pyrophosphate binding site [chemical binding]; other site
435590002842	dimerization interface [polypeptide binding]; other site
435590002843	allosteric effector site; other site
435590002844	fructose-1,6-bisphosphate binding site; other site
435590002845	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590002846	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590002847	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590002848	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590002849	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590002850	Sulfatase; Region: Sulfatase; cl10460
435590002851	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
435590002852	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
435590002853	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
435590002854	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
435590002855	Raffinose synthase or seed inhibition protein Sip1; Region: Raffinose_syn; cl14104
435590002856	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
435590002857	Sulfatase; Region: Sulfatase; cl10460
435590002858	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
435590002859	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
435590002860	dimerization interface [polypeptide binding]; other site
435590002861	active site
435590002862	metal binding site [ion binding]; metal-binding site
435590002863	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
435590002864	dsRNA binding site [nucleotide binding]; other site
435590002865	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
435590002866	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
435590002867	dimer interface [polypeptide binding]; other site
435590002868	active site
435590002869	Phosphopantetheine attachment site; Region: PP-binding; cl09936
435590002870	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
435590002871	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
435590002872	active site
435590002873	substrate binding site [chemical binding]; other site
435590002874	cosubstrate binding site; other site
435590002875	catalytic site [active]
435590002876	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590002877	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590002878	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590002879	DNA binding residues [nucleotide binding]
435590002880	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590002881	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590002882	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590002883	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590002884	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
435590002885	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590002886	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590002887	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590002888	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590002889	DNA binding residues [nucleotide binding]
435590002890	FecR protein; Region: FecR; pfam04773
435590002891	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590002892	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590002893	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
435590002894	Domain of unknown function (DUF4249); Region: DUF4249; pfam14054
435590002895	erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257
435590002896	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590002897	Domain of unknown function (DUF3410); Region: DUF3410; pfam11890
435590002898	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
435590002899	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
435590002900	putative active site [active]
435590002901	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
435590002902	putative acyl-acceptor binding pocket; other site
435590002903	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
435590002904	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590002905	UDP-galactopyranose mutase; Region: GLF; pfam03275
435590002906	Hexokinase; Region: Hexokinase_2; pfam03727
435590002907	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
435590002908	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
435590002909	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185
435590002910	Probable Catalytic site; other site
435590002911	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
435590002912	active site
435590002913	Core-2/I-Branching enzyme; Region: Branch; pfam02485
435590002914	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
435590002915	putative ADP-binding pocket [chemical binding]; other site
435590002916	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590002917	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
435590002918	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
435590002919	active site
435590002920	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
435590002921	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
435590002922	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
435590002923	Walker A/P-loop; other site
435590002924	ATP binding site [chemical binding]; other site
435590002925	Q-loop/lid; other site
435590002926	ABC transporter signature motif; other site
435590002927	Walker B; other site
435590002928	D-loop; other site
435590002929	H-loop/switch region; other site
435590002930	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
435590002931	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
435590002932	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
435590002933	active site
435590002934	Sulfatase; Region: Sulfatase; cl10460
435590002935	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
435590002936	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
435590002937	Ligand binding site; other site
435590002938	Putative Catalytic site; other site
435590002939	DXD motif; other site
435590002940	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
435590002941	GtrA-like protein; Region: GtrA; cl00971
435590002942	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
435590002943	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
435590002944	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
435590002945	Sulfatase; Region: Sulfatase; cl10460
435590002946	Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341
435590002947	Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693
435590002948	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222
435590002949	RNA/DNA hybrid binding site [nucleotide binding]; other site
435590002950	active site
435590002951	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
435590002952	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104
435590002953	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
435590002954	active site
435590002955	HIGH motif; other site
435590002956	nucleotide binding site [chemical binding]; other site
435590002957	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
435590002958	KMSK motif region; other site
435590002959	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
435590002960	tRNA binding surface [nucleotide binding]; other site
435590002961	anticodon binding site; other site
435590002962	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590002963	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590002964	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590002965	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590002966	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590002967	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
435590002968	Peptidase family U32; Region: Peptidase_U32; cl03113
435590002969	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
435590002970	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
435590002971	FMN binding site [chemical binding]; other site
435590002972	active site
435590002973	catalytic residues [active]
435590002974	substrate binding site [chemical binding]; other site
435590002975	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
435590002976	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
435590002977	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
435590002978	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590002979	NAD(P) binding site [chemical binding]; other site
435590002980	active site
435590002981	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
435590002982	Cation efflux family; Region: Cation_efflux; cl00316
435590002983	ribonuclease R; Region: RNase_R; TIGR02063
435590002984	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
435590002985	RNB domain; Region: RNB; pfam00773
435590002986	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471
435590002987	RNA binding site [nucleotide binding]; other site
435590002988	serine O-acetyltransferase; Region: cysE; TIGR01172
435590002989	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
435590002990	trimer interface [polypeptide binding]; other site
435590002991	active site
435590002992	substrate binding site [chemical binding]; other site
435590002993	CoA binding site [chemical binding]; other site
435590002994	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
435590002995	THUMP domain; Region: THUMP; cl12076
435590002996	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590002997	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
435590002998	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
435590002999	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
435590003000	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
435590003001	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
435590003002	ATP-grasp domain; Region: ATP-grasp_4; cl03087
435590003003	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
435590003004	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
435590003005	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
435590003006	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
435590003007	Metal binding protein ZntC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018
435590003008	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
435590003009	putative metal binding residues [ion binding]; other site
435590003010	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
435590003011	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235
435590003012	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
435590003013	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959
435590003014	NodB motif; other site
435590003015	putative active site [active]
435590003016	putative catalytic site [active]
435590003017	putative Zn binding site [ion binding]; other site
435590003018	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
435590003019	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
435590003020	NADP binding site [chemical binding]; other site
435590003021	homodimer interface [polypeptide binding]; other site
435590003022	active site
435590003023	KduI/IolB family; Region: KduI; cl01508
435590003024	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
435590003025	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
435590003026	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
435590003027	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
435590003028	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
435590003029	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
435590003030	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
435590003031	ORF6N domain; Region: ORF6N; pfam10543
435590003032	L-aspartate oxidase; Provisional; Region: PRK09077
435590003033	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590003034	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
435590003035	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
435590003036	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
435590003037	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
435590003038	REJ domain; Region: REJ; pfam02010
435590003039	Pectic acid lyase; Region: Pec_lyase; pfam09492
435590003040	Pectinesterase; Region: Pectinesterase; cl01911
435590003041	Pectin methylesterase [Carbohydrate transport and metabolism]; Region: PemB; COG4677
435590003042	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590003043	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590003044	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590003045	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590003046	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590003047	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
435590003048	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
435590003049	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
435590003050	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
435590003051	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
435590003052	Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004
435590003053	putative substrate binding site [chemical binding]; other site
435590003054	active site
435590003055	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
435590003056	sugar binding site [chemical binding]; other site
435590003057	Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102
435590003058	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
435590003059	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
435590003060	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590003061	SusD family; Region: SusD; pfam07980
435590003062	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590003063	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590003064	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590003065	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
435590003066	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
435590003067	multiple promoter invertase; Provisional; Region: mpi; PRK13413
435590003068	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
435590003069	catalytic residues [active]
435590003070	catalytic nucleophile [active]
435590003071	Presynaptic Site I dimer interface [polypeptide binding]; other site
435590003072	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
435590003073	Synaptic Flat tetramer interface [polypeptide binding]; other site
435590003074	Synaptic Site I dimer interface [polypeptide binding]; other site
435590003075	DNA binding site [nucleotide binding]
435590003076	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
435590003077	DNA-binding interface [nucleotide binding]; DNA binding site
435590003078	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
435590003079	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
435590003080	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590003081	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590003082	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590003083	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590003084	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
435590003085	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
435590003086	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
435590003087	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590003088	Two component regulator propeller; Region: Reg_prop; pfam07494
435590003089	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590003090	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590003091	dimer interface [polypeptide binding]; other site
435590003092	phosphorylation site [posttranslational modification]
435590003093	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590003094	ATP binding site [chemical binding]; other site
435590003095	Mg2+ binding site [ion binding]; other site
435590003096	G-X-G motif; other site
435590003097	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590003098	Response regulator receiver domain; Region: Response_reg; pfam00072
435590003099	active site
435590003100	phosphorylation site [posttranslational modification]
435590003101	intermolecular recognition site; other site
435590003102	dimerization interface [polypeptide binding]; other site
435590003103	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590003104	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590003105	Rubrerythrin [Energy production and conversion]; Region: COG1592
435590003106	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
435590003107	binuclear metal center [ion binding]; other site
435590003108	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
435590003109	iron binding site [ion binding]; other site
435590003110	Sulfate transporter family; Region: Sulfate_transp; cl15842
435590003111	putative transporter; Provisional; Region: PRK11660
435590003112	Sulfate transporter family; Region: Sulfate_transp; cl15842
435590003113	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
435590003114	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590003115	FeS/SAM binding site; other site
435590003116	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
435590003117	Domain of unknown function (DUF4294); Region: DUF4294; pfam14127
435590003118	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
435590003119	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590003120	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590003121	Quinolinate synthetase A protein; Region: NadA; cl00420
435590003122	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
435590003123	active site
435590003124	dimerization interface [polypeptide binding]; other site
435590003125	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
435590003126	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
435590003127	Uncharacterized conserved protein [Function unknown]; Region: COG1284
435590003128	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
435590003129	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
435590003130	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498
435590003131	leucyl-tRNA synthetase, eubacterial and mitochondrial family; Region: leuS_bact; TIGR00396
435590003132	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
435590003133	active site
435590003134	HIGH motif; other site
435590003135	nucleotide binding site [chemical binding]; other site
435590003136	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
435590003137	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
435590003138	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
435590003139	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
435590003140	active site
435590003141	KMSKS motif; other site
435590003142	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
435590003143	tRNA binding surface [nucleotide binding]; other site
435590003144	Two component regulator propeller; Region: Reg_prop; pfam07494
435590003145	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590003146	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590003147	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
435590003148	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590003149	dimer interface [polypeptide binding]; other site
435590003150	phosphorylation site [posttranslational modification]
435590003151	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590003152	ATP binding site [chemical binding]; other site
435590003153	Mg2+ binding site [ion binding]; other site
435590003154	G-X-G motif; other site
435590003155	Response regulator receiver domain; Region: Response_reg; pfam00072
435590003156	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590003157	active site
435590003158	phosphorylation site [posttranslational modification]
435590003159	intermolecular recognition site; other site
435590003160	dimerization interface [polypeptide binding]; other site
435590003161	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590003162	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590003163	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
435590003164	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590003165	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
435590003166	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590003167	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590003168	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590003169	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590003170	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590003171	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590003172	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590003173	Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946
435590003174	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
435590003175	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
435590003176	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
435590003177	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
435590003178	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
435590003179	protein binding site [polypeptide binding]; other site
435590003180	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
435590003181	Domain interface; other site
435590003182	Peptide binding site; other site
435590003183	Active site tetrad [active]
435590003184	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590003185	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590003186	Helix-turn-helix domains; Region: HTH; cl00088
435590003187	dimerization interface [polypeptide binding]; other site
435590003188	DNA binding residues [nucleotide binding]
435590003189	FecR protein; Region: FecR; pfam04773
435590003190	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
435590003191	Secretin and TonB N terminus short domain; Region: STN; cl06624
435590003192	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590003193	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590003194	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590003195	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590003196	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590003197	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590003198	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
435590003199	Sulfatase; Region: Sulfatase; cl10460
435590003200	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
435590003201	Sulfatase; Region: Sulfatase; cl10460
435590003202	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
435590003203	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590003204	Walker A/P-loop; other site
435590003205	ATP binding site [chemical binding]; other site
435590003206	ABC transporter signature motif; other site
435590003207	Walker B; other site
435590003208	D-loop; other site
435590003209	H-loop/switch region; other site
435590003210	ABC transporter; Region: ABC_tran_2; pfam12848
435590003211	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
435590003212	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
435590003213	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
435590003214	PA14 domain; Region: PA14; cl08459
435590003215	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
435590003216	Fibronectin type III-like domain; Region: Fn3-like; cl15273
435590003217	succinate CoA transferases; Region: YgfH_subfam; TIGR03458
435590003218	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
435590003219	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
435590003220	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329
435590003221	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
435590003222	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590003223	FeS/SAM binding site; other site
435590003224	TRAM domain; Region: TRAM; cl01282
435590003225	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
435590003226	PspC domain; Region: PspC; cl00864
435590003227	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590003228	S-adenosylmethionine binding site [chemical binding]; other site
435590003229	FtsX-like permease family; Region: FtsX; cl15850
435590003230	Protein of unknown function (DUF3098); Region: DUF3098; pfam11297
435590003231	Bacitracin resistance protein BacA; Region: BacA; cl00858
435590003232	PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573
435590003233	RNA binding site [nucleotide binding]; other site
435590003234	active site
435590003235	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
435590003236	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
435590003237	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
435590003238	catalytic center binding site [active]
435590003239	ATP binding site [chemical binding]; other site
435590003240	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
435590003241	Domain of unknown function (DUF3244); Region: DUF3244; pfam11589
435590003242	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
435590003243	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
435590003244	Integrase core domain; Region: rve; cl01316
435590003245	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
435590003246	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
435590003247	OpgC protein; Region: OpgC_C; cl00792
435590003248	Acyltransferase family; Region: Acyl_transf_3; pfam01757
435590003249	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
435590003250	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
435590003251	putative catalytic site [active]
435590003252	putative phosphate binding site [ion binding]; other site
435590003253	putative metal binding site [ion binding]; other site
435590003254	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590003255	Major Facilitator Superfamily; Region: MFS_1; pfam07690
435590003256	putative substrate translocation pore; other site
435590003257	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590003258	S-adenosylmethionine synthetase; Validated; Region: PRK05250
435590003259	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
435590003260	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
435590003261	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
435590003262	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
435590003263	Domain of unknown function (DUF4271); Region: DUF4271; pfam14093
435590003264	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
435590003265	active site
435590003266	Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602
435590003267	Ribonuclease P; Region: Ribonuclease_P; cl00457
435590003268	Haemolytic domain; Region: Haemolytic; cl00506
435590003269	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
435590003270	active site
435590003271	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
435590003272	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
435590003273	active site
435590003274	HIGH motif; other site
435590003275	dimer interface [polypeptide binding]; other site
435590003276	KMSKS motif; other site
435590003277	Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946
435590003278	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
435590003279	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
435590003280	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
435590003281	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
435590003282	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
435590003283	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
435590003284	protein binding site [polypeptide binding]; other site
435590003285	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
435590003286	Domain interface; other site
435590003287	Peptide binding site; other site
435590003288	Active site tetrad [active]
435590003289	Flavin Reductases; Region: FlaRed; cl00801
435590003290	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
435590003291	MutS domain I; Region: MutS_I; pfam01624
435590003292	MutS domain II; Region: MutS_II; pfam05188
435590003293	MutS family domain IV; Region: MutS_IV; pfam05190
435590003294	MutS1 homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284
435590003295	Walker A/P-loop; other site
435590003296	ATP binding site [chemical binding]; other site
435590003297	Q-loop/lid; other site
435590003298	ABC transporter signature motif; other site
435590003299	Walker B; other site
435590003300	D-loop; other site
435590003301	H-loop/switch region; other site
435590003302	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
435590003303	Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564
435590003304	active site
435590003305	Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102
435590003306	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
435590003307	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590003308	binding surface
435590003309	TPR motif; other site
435590003310	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590003311	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590003312	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590003313	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590003314	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
435590003315	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
435590003316	Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845
435590003317	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
435590003318	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
435590003319	Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893
435590003320	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590003321	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
435590003322	GTP-binding protein YchF; Reviewed; Region: PRK09601
435590003323	YchF GTPase; Region: YchF; cd01900
435590003324	G1 box; other site
435590003325	GTP/Mg2+ binding site [chemical binding]; other site
435590003326	Switch I region; other site
435590003327	G2 box; other site
435590003328	Switch II region; other site
435590003329	G3 box; other site
435590003330	G4 box; other site
435590003331	G5 box; other site
435590003332	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
435590003333	Family of unknown function (DUF3836); Region: DUF3836; pfam12930
435590003334	DNA polymerase I; Region: pola; TIGR00593
435590003335	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
435590003336	active site
435590003337	metal binding site 1 [ion binding]; metal-binding site
435590003338	putative 5' ssDNA interaction site; other site
435590003339	metal binding site 3; metal-binding site
435590003340	metal binding site 2 [ion binding]; metal-binding site
435590003341	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
435590003342	putative DNA binding site [nucleotide binding]; other site
435590003343	putative metal binding site [ion binding]; other site
435590003344	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
435590003345	active site
435590003346	catalytic site [active]
435590003347	substrate binding site [chemical binding]; other site
435590003348	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
435590003349	active site
435590003350	DNA binding site [nucleotide binding]
435590003351	catalytic site [active]
435590003352	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
435590003353	substrate binding pocket [chemical binding]; other site
435590003354	chain length determination region; other site
435590003355	substrate-Mg2+ binding site; other site
435590003356	catalytic residues [active]
435590003357	aspartate-rich region 1; other site
435590003358	active site lid residues [active]
435590003359	aspartate-rich region 2; other site
435590003360	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
435590003361	intersubunit interface [polypeptide binding]; other site
435590003362	active site
435590003363	catalytic residue [active]
435590003364	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
435590003365	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
435590003366	putative active site [active]
435590003367	dimerization interface [polypeptide binding]; other site
435590003368	putative tRNAtyr binding site [nucleotide binding]; other site
435590003369	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
435590003370	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
435590003371	GIY-YIG motif/motif A; other site
435590003372	active site
435590003373	catalytic site [active]
435590003374	putative DNA binding site [nucleotide binding]; other site
435590003375	metal binding site [ion binding]; metal-binding site
435590003376	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cd00758
435590003377	Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503
435590003378	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
435590003379	active site
435590003380	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
435590003381	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590003382	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
435590003383	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
435590003384	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
435590003385	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
435590003386	Nucleoside recognition; Region: Gate; cl00486
435590003387	Nucleoside recognition; Region: Gate; cl00486
435590003388	BRO family, N-terminal domain; Region: Bro-N; cl10591
435590003389	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
435590003390	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
435590003391	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590003392	DNA binding site [nucleotide binding]
435590003393	Int/Topo IB signature motif; other site
435590003394	active site
435590003395	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
435590003396	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
435590003397	Integrase core domain; Region: rve; cl01316
435590003398	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
435590003399	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590003400	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
435590003401	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590003402	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
435590003403	ligand-binding site [chemical binding]; other site
435590003404	Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378
435590003405	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
435590003406	active site
435590003407	metal binding site [ion binding]; metal-binding site
435590003408	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
435590003409	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
435590003410	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
435590003411	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
435590003412	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590003413	ATP binding site [chemical binding]; other site
435590003414	Mg2+ binding site [ion binding]; other site
435590003415	G-X-G motif; other site
435590003416	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783
435590003417	ATP binding site [chemical binding]; other site
435590003418	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030
435590003419	active site
435590003420	putative metal-binding site [ion binding]; other site
435590003421	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
435590003422	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
435590003423	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
435590003424	active site
435590003425	(T/H)XGH motif; other site
435590003426	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
435590003427	C-terminal peptidase (prc); Region: prc; TIGR00225
435590003428	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
435590003429	protein binding site [polypeptide binding]; other site
435590003430	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
435590003431	Catalytic dyad [active]
435590003432	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
435590003433	active site
435590003434	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
435590003435	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
435590003436	putative Iron-sulfur protein interface [polypeptide binding]; other site
435590003437	proximal heme binding site [chemical binding]; other site
435590003438	distal heme binding site [chemical binding]; other site
435590003439	putative dimer interface [polypeptide binding]; other site
435590003440	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
435590003441	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590003442	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
435590003443	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
435590003444	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
435590003445	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
435590003446	Protein of unknown function (DUF3988); Region: DUF3988; pfam13149
435590003447	Protein of unknown function (DUF3575); Region: DUF3575; pfam12099
435590003448	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
435590003449	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
435590003450	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
435590003451	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
435590003452	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
435590003453	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
435590003454	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
435590003455	active site
435590003456	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
435590003457	FMN binding site [chemical binding]; other site
435590003458	active site
435590003459	catalytic residues [active]
435590003460	substrate binding site [chemical binding]; other site
435590003461	Virulence-associated protein E; Region: VirE; pfam05272
435590003462	Domain of unknonw function from B. Theta Gene description (DUF3874); Region: DUF3874; pfam12990
435590003463	L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624
435590003464	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
435590003465	dimer interface [polypeptide binding]; other site
435590003466	active site
435590003467	metal binding site [ion binding]; metal-binding site
435590003468	Protein of unknown function (DUF1351); Region: DUF1351; pfam07083
435590003469	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590003470	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590003471	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590003472	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590003473	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
435590003474	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590003475	Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383
435590003476	putative active site [active]
435590003477	putative metal binding site [ion binding]; other site
435590003478	Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383
435590003479	Protein of unknown function (DUF2851); Region: DUF2851; pfam11013
435590003480	dihydrodipicolinate reductase; Provisional; Region: PRK00048
435590003481	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590003482	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
435590003483	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
435590003484	signal peptidase I; Provisional; Region: PRK10861
435590003485	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
435590003486	Catalytic site [active]
435590003487	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
435590003488	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
435590003489	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
435590003490	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
435590003491	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
435590003492	Catalytic site [active]
435590003493	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
435590003494	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
435590003495	WbqC-like protein family; Region: WbqC; pfam08889
435590003496	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590003497	NAD(P) binding site [chemical binding]; other site
435590003498	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
435590003499	active site
435590003500	mannonate dehydratase; Provisional; Region: PRK03906
435590003501	mannonate dehydratase; Region: uxuA; TIGR00695
435590003502	Transposase domain (DUF772); Region: DUF772; cl15789
435590003503	Transposase domain (DUF772); Region: DUF772; cl15789
435590003504	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590003505	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590003506	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590003507	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590003508	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590003509	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590003510	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590003511	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
435590003512	Sulfatase; Region: Sulfatase; cl10460
435590003513	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590003514	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590003515	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590003516	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
435590003517	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
435590003518	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590003519	ATP binding site [chemical binding]; other site
435590003520	Mg2+ binding site [ion binding]; other site
435590003521	G-X-G motif; other site
435590003522	Response regulator receiver domain; Region: Response_reg; pfam00072
435590003523	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590003524	active site
435590003525	phosphorylation site [posttranslational modification]
435590003526	intermolecular recognition site; other site
435590003527	dimerization interface [polypeptide binding]; other site
435590003528	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590003529	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590003530	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
435590003531	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
435590003532	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
435590003533	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
435590003534	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
435590003535	Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane]; Region: GutQ; COG0794
435590003536	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
435590003537	putative active site [active]
435590003538	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
435590003539	putative substrate binding site [chemical binding]; other site
435590003540	putative ATP binding site [chemical binding]; other site
435590003541	Glyco_18 domain; Region: Glyco_18; smart00636
435590003542	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
435590003543	active site
435590003544	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
435590003545	Peptidase family M1; Region: Peptidase_M1; pfam01433
435590003546	Zn binding site [ion binding]; other site
435590003547	tRNA-specific 2-thiouridylase MnmA; Provisional; Region: PRK14664
435590003548	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
435590003549	Ligand Binding Site [chemical binding]; other site
435590003550	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
435590003551	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
435590003552	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
435590003553	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
435590003554	Clostripain family; Region: Peptidase_C11; cl04055
435590003555	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
435590003556	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
435590003557	Protein of unknown function (DUF3988); Region: DUF3988; pfam13149
435590003558	Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842
435590003559	Virulence-associated protein E; Region: VirE; pfam05272
435590003560	Domain of unknonw function from B. Theta Gene description (DUF3874); Region: DUF3874; pfam12990
435590003561	Transposase domain (DUF772); Region: DUF772; cl15789
435590003562	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590003563	Transposase domain (DUF772); Region: DUF772; cl15789
435590003564	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590003565	Protein of unknown function (DUF3946); Region: DUF3946; pfam13102
435590003566	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590003567	DNA binding site [nucleotide binding]
435590003568	Int/Topo IB signature motif; other site
435590003569	active site
435590003570	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
435590003571	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590003572	Walker A motif; other site
435590003573	ATP binding site [chemical binding]; other site
435590003574	Walker B motif; other site
435590003575	arginine finger; other site
435590003576	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
435590003577	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
435590003578	MatE; Region: MatE; cl10513
435590003579	Domain of unknown function (DUF389); Region: DUF389; cl00781
435590003580	Peptidase S46; Region: Peptidase_S46; pfam10459
435590003581	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
435590003582	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
435590003583	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
435590003584	ATP binding site [chemical binding]; other site
435590003585	Mg++ binding site [ion binding]; other site
435590003586	motif III; other site
435590003587	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590003588	nucleotide binding region [chemical binding]; other site
435590003589	ATP-binding site [chemical binding]; other site
435590003590	DbpA RNA binding domain; Region: DbpA; pfam03880
435590003591	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
435590003592	Protein of unknown function (DUF2975); Region: DUF2975; pfam11188
435590003593	CAAX protease self-immunity; Region: Abi; cl00558
435590003594	Family of unknown function (DUF3836); Region: DUF3836; pfam12930
435590003595	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
435590003596	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
435590003597	active site
435590003598	Riboflavin kinase; Region: Flavokinase; cl03312
435590003599	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
435590003600	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
435590003601	plasma-membrane calcium-translocating P-type ATPase; Region: ATPase-IIB_Ca; TIGR01517
435590003602	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
435590003603	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
435590003604	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
435590003605	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
435590003606	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
435590003607	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
435590003608	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
435590003609	Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976
435590003610	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
435590003611	catalytic residues [active]
435590003612	Helix-turn-helix domains; Region: HTH; cl00088
435590003613	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
435590003614	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590003615	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
435590003616	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590003617	active site
435590003618	phosphorylation site [posttranslational modification]
435590003619	intermolecular recognition site; other site
435590003620	dimerization interface [polypeptide binding]; other site
435590003621	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
435590003622	DNA binding site [nucleotide binding]
435590003623	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590003624	dimer interface [polypeptide binding]; other site
435590003625	phosphorylation site [posttranslational modification]
435590003626	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590003627	ATP binding site [chemical binding]; other site
435590003628	Mg2+ binding site [ion binding]; other site
435590003629	G-X-G motif; other site
435590003630	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
435590003631	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590003632	Fe-S metabolism associated domain; Region: SufE; cl00951
435590003633	M28 Zn-Peptidases; Region: M28_like_6; cd08656
435590003634	metal binding site [ion binding]; metal-binding site
435590003635	Peptidase C26; Region: Peptidase_C26; pfam07722
435590003636	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
435590003637	catalytic triad [active]
435590003638	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
435590003639	active site
435590003640	dimer interface [polypeptide binding]; other site
435590003641	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
435590003642	Acetokinase family; Region: Acetate_kinase; cl01029
435590003643	Virulence-associated protein E; Region: VirE; pfam05272
435590003644	Domain of unknonw function from B. Theta Gene description (DUF3874); Region: DUF3874; pfam12990
435590003645	Integrase core domain; Region: rve; cl01316
435590003646	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
435590003647	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
435590003648	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
435590003649	Helix-turn-helix domains; Region: HTH; cl00088
435590003650	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
435590003651	Domain of unknown function DUF21; Region: DUF21; pfam01595
435590003652	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
435590003653	Transporter associated domain; Region: CorC_HlyC; cl08393
435590003654	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
435590003655	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_22; cd04681
435590003656	nudix motif; other site
435590003657	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
435590003658	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
435590003659	binding surface
435590003660	TPR motif; other site
435590003661	TPR repeat; Region: TPR_11; pfam13414
435590003662	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
435590003663	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
435590003664	Tetratricopeptide repeat; Region: TPR_6; pfam13174
435590003665	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
435590003666	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
435590003667	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590003668	DNA topoisomerase I; Provisional; Region: PRK08780
435590003669	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
435590003670	active site
435590003671	interdomain interaction site; other site
435590003672	putative metal-binding site [ion binding]; other site
435590003673	nucleotide binding site [chemical binding]; other site
435590003674	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
435590003675	domain I; other site
435590003676	DNA binding groove [nucleotide binding]
435590003677	phosphate binding site [ion binding]; other site
435590003678	domain II; other site
435590003679	domain III; other site
435590003680	nucleotide binding site [chemical binding]; other site
435590003681	catalytic site [active]
435590003682	domain IV; other site
435590003683	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
435590003684	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
435590003685	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
435590003686	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
435590003687	Shikimate kinase; Region: SKI; pfam01202
435590003688	ADP binding site [chemical binding]; other site
435590003689	magnesium binding site [ion binding]; other site
435590003690	putative shikimate binding site; other site
435590003691	arginine decarboxylase; Provisional; Region: PRK05354
435590003692	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
435590003693	dimer interface [polypeptide binding]; other site
435590003694	active site
435590003695	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
435590003696	catalytic residues [active]
435590003697	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
435590003698	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
435590003699	nucleotide binding site [chemical binding]; other site
435590003700	N-acetyl-L-glutamate binding site [chemical binding]; other site
435590003701	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590003702	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
435590003703	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590003704	DNA binding residues [nucleotide binding]
435590003705	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
435590003706	Protein of unknown function DUF45; Region: DUF45; cl00636
435590003707	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
435590003708	PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750
435590003709	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
435590003710	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
435590003711	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590003712	FeS/SAM binding site; other site
435590003713	MFS transport protein AraJ; Provisional; Region: PRK10091
435590003714	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590003715	putative substrate translocation pore; other site
435590003716	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
435590003717	Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576
435590003718	transcription termination factor NusA; Region: NusA; TIGR01953
435590003719	NusA N-terminal domain; Region: NusA_N; pfam08529
435590003720	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
435590003721	RNA binding site [nucleotide binding]; other site
435590003722	homodimer interface [polypeptide binding]; other site
435590003723	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
435590003724	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
435590003725	G-X-X-G motif; other site
435590003726	translation initiation factor IF-2; Region: IF-2; TIGR00487
435590003727	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
435590003728	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
435590003729	G1 box; other site
435590003730	putative GEF interaction site [polypeptide binding]; other site
435590003731	GTP/Mg2+ binding site [chemical binding]; other site
435590003732	Switch I region; other site
435590003733	G2 box; other site
435590003734	G3 box; other site
435590003735	Switch II region; other site
435590003736	G4 box; other site
435590003737	G5 box; other site
435590003738	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
435590003739	Translation-initiation factor 2; Region: IF-2; pfam11987
435590003740	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
435590003741	Colicin V production protein; Region: Colicin_V; cl00567
435590003742	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
435590003743	putative ABC transporter; Region: ycf24; CHL00085
435590003744	FeS assembly ATPase SufC; Region: sufC; TIGR01978
435590003745	ABC-type transport system involved in Fe-S cluster assembly, ATPase component.  Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems.  The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217
435590003746	Walker A/P-loop; other site
435590003747	ATP binding site [chemical binding]; other site
435590003748	Q-loop/lid; other site
435590003749	ABC transporter signature motif; other site
435590003750	Walker B; other site
435590003751	D-loop; other site
435590003752	H-loop/switch region; other site
435590003753	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
435590003754	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
435590003755	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
435590003756	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
435590003757	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
435590003758	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
435590003759	catalytic residue [active]
435590003760	Transposase domain (DUF772); Region: DUF772; cl15789
435590003761	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590003762	Transposase domain (DUF772); Region: DUF772; cl15789
435590003763	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
435590003764	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
435590003765	Coenzyme A binding pocket [chemical binding]; other site
435590003766	alpha-glucosidase; Provisional; Region: PRK10137
435590003767	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801
435590003768	beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525
435590003769	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
435590003770	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590003771	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
435590003772	Beta galactosidase small chain; Region: Bgal_small_N; cl03787
435590003773	Membrane protein of unknown function (DUF340); Region: DUF340; cl01028
435590003774	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590003775	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590003776	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590003777	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590003778	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590003779	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590003780	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590003781	binding surface
435590003782	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590003783	TPR motif; other site
435590003784	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590003785	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
435590003786	RNA/DNA hybrid binding site [nucleotide binding]; other site
435590003787	active site
435590003788	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
435590003789	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
435590003790	L-fucose isomerase; Provisional; Region: fucI; PRK10991
435590003791	L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556
435590003792	hexamer (dimer of trimers) interface [polypeptide binding]; other site
435590003793	trimer interface [polypeptide binding]; other site
435590003794	substrate binding site [chemical binding]; other site
435590003795	Mn binding site [ion binding]; other site
435590003796	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
435590003797	DNA-binding site [nucleotide binding]; DNA binding site
435590003798	Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276
435590003799	putative dimerization interface [polypeptide binding]; other site
435590003800	putative ligand binding site [chemical binding]; other site
435590003801	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
435590003802	Sulfatase; Region: Sulfatase; cl10460
435590003803	Protein of unknown function (DUF3109); Region: DUF3109; pfam11307
435590003804	Phosphate-selective porin O and P; Region: Porin_O_P; cl01524
435590003805	SusE outer membrane protein; Region: SusE; pfam14292
435590003806	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590003807	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590003808	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590003809	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590003810	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590003811	Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566
435590003812	Cyclomaltodextrinase, N-terminal; Region: Cyc-maltodext_N; pfam09087
435590003813	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_3; cd11340
435590003814	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
435590003815	Ca binding site [ion binding]; other site
435590003816	active site
435590003817	homodimer interface [polypeptide binding]; other site
435590003818	catalytic site [active]
435590003819	Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438
435590003820	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590003821	GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301
435590003822	Major Facilitator Superfamily; Region: MFS_1; pfam07690
435590003823	The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347
435590003824	4-alpha-glucanotransferase; Region: PLN02950
435590003825	starch-binding site 2 [chemical binding]; other site
435590003826	starch-binding site 1 [chemical binding]; other site
435590003827	Disproportionating enzyme 2 (DPE2), N-terminal CBM20 (carbohydrate-binding module, family 20) domain, repeat 2. DPE2 is a transglucosidase that is essential for the cytosolic metabolism of maltose in plant leaves at night. Maltose is an intermediate on...; Region: CBM20_DPE2_repeat2; cd05816
435590003828	starch binding site 2 [chemical binding]; other site
435590003829	starch binding site 1 [chemical binding]; other site
435590003830	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
435590003831	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
435590003832	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590003833	ATP binding site [chemical binding]; other site
435590003834	Mg2+ binding site [ion binding]; other site
435590003835	G-X-G motif; other site
435590003836	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
435590003837	anchoring element; other site
435590003838	dimer interface [polypeptide binding]; other site
435590003839	ATP binding site [chemical binding]; other site
435590003840	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
435590003841	active site
435590003842	putative metal-binding site [ion binding]; other site
435590003843	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
435590003844	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
435590003845	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
435590003846	Recombination protein O N terminal; Region: RecO_N; cl15812
435590003847	Recombination protein O C terminal; Region: RecO_C; pfam02565
435590003848	GatB domain; Region: GatB_Yqey; cl11497
435590003849	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
435590003850	nucleotide binding site [chemical binding]; other site
435590003851	SulA interaction site; other site
435590003852	cell division protein FtsA; Region: ftsA; TIGR01174
435590003853	Cell division protein FtsA; Region: FtsA; cl11496
435590003854	Cell division protein FtsA; Region: FtsA; cl11496
435590003855	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
435590003856	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
435590003857	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
435590003858	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
435590003859	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
435590003860	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
435590003861	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
435590003862	homodimer interface [polypeptide binding]; other site
435590003863	active site
435590003864	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
435590003865	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
435590003866	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
435590003867	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
435590003868	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
435590003869	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
435590003870	Mg++ binding site [ion binding]; other site
435590003871	putative catalytic motif [active]
435590003872	putative substrate binding site [chemical binding]; other site
435590003873	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
435590003874	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
435590003875	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
435590003876	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
435590003877	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
435590003878	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
435590003879	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
435590003880	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
435590003881	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
435590003882	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
435590003883	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590003884	cell division protein MraZ; Reviewed; Region: PRK00326
435590003885	MraZ protein; Region: MraZ; pfam02381
435590003886	MraZ protein; Region: MraZ; pfam02381
435590003887	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
435590003888	putative acyl-acceptor binding pocket; other site
435590003889	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
435590003890	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
435590003891	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
435590003892	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
435590003893	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
435590003894	trimer interface [polypeptide binding]; other site
435590003895	active site
435590003896	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590003897	binding surface
435590003898	TPR motif; other site
435590003899	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590003900	binding surface
435590003901	TPR motif; other site
435590003902	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590003903	TPR motif; other site
435590003904	binding surface
435590003905	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590003906	TPR motif; other site
435590003907	binding surface
435590003908	Domain of unknown function (DUF4292); Region: DUF4292; pfam14125
435590003909	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
435590003910	Peptidase family M23; Region: Peptidase_M23; pfam01551
435590003911	RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590
435590003912	RNA/DNA binding site [nucleotide binding]; other site
435590003913	RRM dimerization site [polypeptide binding]; other site
435590003914	Glutaminase; Region: Glutaminase; cl00907
435590003915	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional; Region: PRK02048
435590003916	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
435590003917	AIR carboxylase; Region: AIRC; cl00310
435590003918	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
435590003919	lipoyl attachment site [posttranslational modification]; other site
435590003920	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
435590003921	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
435590003922	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
435590003923	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
435590003924	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
435590003925	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
435590003926	pyruvate formate-lyase; Region: PFL2-3; TIGR01774
435590003927	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
435590003928	dimer interface [polypeptide binding]; other site
435590003929	active site
435590003930	glycine loop; other site
435590003931	threonyl-tRNA synthetase; Reviewed; Region: PRK12444
435590003932	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
435590003933	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
435590003934	active site
435590003935	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
435590003936	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
435590003937	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
435590003938	PhoU domain; Region: PhoU; pfam01895
435590003939	PhoU domain; Region: PhoU; pfam01895
435590003940	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
435590003941	Transposase domain (DUF772); Region: DUF772; cl15789
435590003942	Transposase domain (DUF772); Region: DUF772; cl15789
435590003943	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
435590003944	peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570
435590003945	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
435590003946	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
435590003947	peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570
435590003948	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
435590003949	NAD-dependent deacetylase; Provisional; Region: PRK00481
435590003950	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
435590003951	NAD+ binding site [chemical binding]; other site
435590003952	substrate binding site [chemical binding]; other site
435590003953	Zn binding site [ion binding]; other site
435590003954	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
435590003955	Rubredoxin; Region: Rubredoxin; pfam00301
435590003956	iron binding site [ion binding]; other site
435590003957	Transposase domain (DUF772); Region: DUF772; cl15789
435590003958	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590003959	Transposase domain (DUF772); Region: DUF772; cl15789
435590003960	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
435590003961	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
435590003962	RNase E interface [polypeptide binding]; other site
435590003963	trimer interface [polypeptide binding]; other site
435590003964	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
435590003965	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
435590003966	RNase E interface [polypeptide binding]; other site
435590003967	trimer interface [polypeptide binding]; other site
435590003968	active site
435590003969	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
435590003970	RNA binding site [nucleotide binding]; other site
435590003971	domain interface; other site
435590003972	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
435590003973	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
435590003974	catalytic residues [active]
435590003975	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
435590003976	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
435590003977	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
435590003978	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
435590003979	nucleotide binding site/active site [active]
435590003980	HIT family signature motif; other site
435590003981	catalytic residue [active]
435590003982	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
435590003983	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
435590003984	Substrate binding site; other site
435590003985	Abi-like protein; Region: Abi_2; cl01988
435590003986	DNA primase, catalytic core; Region: dnaG; TIGR01391
435590003987	CHC2 zinc finger; Region: zf-CHC2; cl15369
435590003988	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
435590003989	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
435590003990	Protein of unknown function DUF91; Region: DUF91; cl00709
435590003991	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
435590003992	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
435590003993	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590003994	DNA binding site [nucleotide binding]
435590003995	Int/Topo IB signature motif; other site
435590003996	active site
435590003997	Fic/DOC family; Region: Fic; cl00960
435590003998	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590003999	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
435590004000	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590004001	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
435590004002	DNA binding residues [nucleotide binding]
435590004003	dimerization interface [polypeptide binding]; other site
435590004004	Transposase domain (DUF772); Region: DUF772; cl15789
435590004005	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590004006	Transposase domain (DUF772); Region: DUF772; cl15789
435590004007	Transposase domain (DUF772); Region: DUF772; cl15789
435590004008	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590004009	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
435590004010	bacteriocin maturation radical SAM protein 1; Region: rSAM_ocin_1; TIGR03975
435590004011	B12 binding site [chemical binding]; other site
435590004012	coproporphyrinogen III oxidase; Provisional; Region: PRK09058
435590004013	Protein of unknown function (DUF4080); Region: DUF4080; pfam13311
435590004014	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
435590004015	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
435590004016	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
435590004017	Coenzyme A binding pocket [chemical binding]; other site
435590004018	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
435590004019	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
435590004020	Coenzyme A binding pocket [chemical binding]; other site
435590004021	Protein of unknown function, DUF488; Region: DUF488; cl01246
435590004022	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
435590004023	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
435590004024	ATP-grasp domain; Region: ATP-grasp_4; cl03087
435590004025	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
435590004026	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
435590004027	carboxyltransferase (CT) interaction site; other site
435590004028	biotinylation site [posttranslational modification]; other site
435590004029	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
435590004030	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
435590004031	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
435590004032	Serine carboxypeptidase S28; Region: Peptidase_S28; cl15279
435590004033	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
435590004034	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
435590004035	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
435590004036	primosome assembly protein PriA; Validated; Region: PRK05580
435590004037	primosome assembly protein PriA; Validated; Region: PRK05580
435590004038	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590004039	ATP binding site [chemical binding]; other site
435590004040	putative Mg++ binding site [ion binding]; other site
435590004041	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590004042	putative hydrolase; Validated; Region: PRK09248
435590004043	RNase P subunit p30; Region: RNase_P_p30; cl03389
435590004044	Low molecular weight phosphatase family; Region: LMWPc; cd00115
435590004045	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
435590004046	active site
435590004047	7TM-HD extracellular; Region: 7TMR-HDED; pfam07697
435590004048	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
435590004049	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
435590004050	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
435590004051	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
435590004052	HIGH motif; other site
435590004053	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
435590004054	active site
435590004055	KMSKS motif; other site
435590004056	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
435590004057	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
435590004058	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590004059	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
435590004060	nudix motif; other site
435590004061	Cupin domain; Region: Cupin_2; cl09118
435590004062	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590004063	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
435590004064	NAD(P) binding site [chemical binding]; other site
435590004065	active site
435590004066	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
435590004067	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like5; cd05651
435590004068	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
435590004069	metal binding site [ion binding]; metal-binding site
435590004070	dimer interface [polypeptide binding]; other site
435590004071	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
435590004072	AMP-binding enzyme; Region: AMP-binding; cl15778
435590004073	peptide chain release factor 2; Validated; Region: prfB; PRK00578
435590004074	RF-1 domain; Region: RF-1; cl02875
435590004075	RF-1 domain; Region: RF-1; cl02875
435590004076	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
435590004077	putative active site [active]
435590004078	putative metal binding residues [ion binding]; other site
435590004079	signature motif; other site
435590004080	putative dimer interface [polypeptide binding]; other site
435590004081	putative phosphate binding site [ion binding]; other site
435590004082	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590004083	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
435590004084	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590004085	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
435590004086	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590004087	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590004088	DNA binding residues [nucleotide binding]
435590004089	Sodium:neurotransmitter symporter family; Region: SNF; cl11976
435590004090	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
435590004091	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
435590004092	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
435590004093	Transposase domain (DUF772); Region: DUF772; cl15789
435590004094	Transposase domain (DUF772); Region: DUF772; cl15789
435590004095	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
435590004096	dimer interface [polypeptide binding]; other site
435590004097	Alkaline phosphatase homologues; Region: alkPPc; smart00098
435590004098	active site
435590004099	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
435590004100	Transposase domain (DUF772); Region: DUF772; cl15789
435590004101	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590004102	Transposase domain (DUF772); Region: DUF772; cl15789
435590004103	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
435590004104	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
435590004105	Divergent AAA domain; Region: AAA_4; pfam04326
435590004106	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
435590004107	Helix-turn-helix domains; Region: HTH; cl00088
435590004108	Cupin domain; Region: Cupin_2; cl09118
435590004109	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590004110	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590004111	maltose O-acetyltransferase; Provisional; Region: PRK10092
435590004112	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
435590004113	active site
435590004114	substrate binding site [chemical binding]; other site
435590004115	trimer interface [polypeptide binding]; other site
435590004116	CoA binding site [chemical binding]; other site
435590004117	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
435590004118	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
435590004119	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
435590004120	active site
435590004121	catalytic triad [active]
435590004122	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590004123	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
435590004124	Walker A motif; other site
435590004125	ATP binding site [chemical binding]; other site
435590004126	Walker B motif; other site
435590004127	arginine finger; other site
435590004128	DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358
435590004129	CHC2 zinc finger; Region: zf-CHC2; cl15369
435590004130	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
435590004131	Domain of unknown function (DUF4121); Region: DUF4121; pfam13497
435590004132	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
435590004133	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590004134	Restriction endonuclease; Region: Mrr_cat; cl00516
435590004135	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
435590004136	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
435590004137	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590004138	ATP binding site [chemical binding]; other site
435590004139	putative Mg++ binding site [ion binding]; other site
435590004140	C-terminal putative phospholipase D-like domain of uncharacterized prokaryotic HKD family nucleases fused to DEAD/DEAH box helicases; Region: PLDc_C_DEXD_like; cd09126
435590004141	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
435590004142	Transposase; Region: DDE_Tnp_ISL3; pfam01610
435590004143	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
435590004144	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
435590004145	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
435590004146	DNA binding residues [nucleotide binding]
435590004147	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
435590004148	putative metal binding site [ion binding]; other site
435590004149	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
435590004150	PRTRC system ThiF family protein; Region: PRTRC_ThiF; TIGR03736
435590004151	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
435590004152	ATP binding site [chemical binding]; other site
435590004153	substrate interface [chemical binding]; other site
435590004154	Prokaryotic E2 family D; Region: Prok-E2_D; cl14019
435590004155	Prokaryotic Ubiquitin; Region: Prok_Ub; cl14020
435590004156	PRTRC system protein E; Region: PRTRC_E; TIGR03741
435590004157	DNA topoisomerase III; Provisional; Region: PRK07726
435590004158	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
435590004159	active site
435590004160	putative interdomain interaction site [polypeptide binding]; other site
435590004161	putative metal-binding site [ion binding]; other site
435590004162	putative nucleotide binding site [chemical binding]; other site
435590004163	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
435590004164	domain I; other site
435590004165	DNA binding groove [nucleotide binding]
435590004166	phosphate binding site [ion binding]; other site
435590004167	domain II; other site
435590004168	domain III; other site
435590004169	nucleotide binding site [chemical binding]; other site
435590004170	catalytic site [active]
435590004171	domain IV; other site
435590004172	Protein of unknown function (DUF4099); Region: DUF4099; pfam13351
435590004173	Protein of unknown function (DUF4099); Region: DUF4099; pfam13351
435590004174	Protein of unknown function (DUF3945); Region: DUF3945; pfam13101
435590004175	Protein of unknown function (DUF3945); Region: DUF3945; pfam13101
435590004176	Protein of unknown function (DUF3945); Region: DUF3945; pfam13101
435590004177	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590004178	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
435590004179	DNA binding site [nucleotide binding]
435590004180	Int/Topo IB signature motif; other site
435590004181	active site
435590004182	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
435590004183	KOW motif; Region: KOW; cl00354
435590004184	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
435590004185	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
435590004186	Mg++ binding site [ion binding]; other site
435590004187	putative catalytic motif [active]
435590004188	substrate binding site [chemical binding]; other site
435590004189	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
435590004190	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
435590004191	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
435590004192	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
435590004193	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590004194	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
435590004195	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
435590004196	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
435590004197	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590004198	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
435590004199	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590004200	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
435590004201	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
435590004202	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
435590004203	NAD(P) binding site [chemical binding]; other site
435590004204	homodimer interface [polypeptide binding]; other site
435590004205	substrate binding site [chemical binding]; other site
435590004206	active site
435590004207	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
435590004208	capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261
435590004209	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
435590004210	putative NAD(P) binding site [chemical binding]; other site
435590004211	active site
435590004212	putative substrate binding site [chemical binding]; other site
435590004213	Cupin domain; Region: Cupin_2; cl09118
435590004214	Cupin domain; Region: Cupin_2; cl09118
435590004215	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
435590004216	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
435590004217	active site
435590004218	homodimer interface [polypeptide binding]; other site
435590004219	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590004220	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
435590004221	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
435590004222	putative trimer interface [polypeptide binding]; other site
435590004223	putative CoA binding site [chemical binding]; other site
435590004224	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
435590004225	putative trimer interface [polypeptide binding]; other site
435590004226	putative CoA binding site [chemical binding]; other site
435590004227	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
435590004228	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
435590004229	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
435590004230	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
435590004231	active site
435590004232	homodimer interface [polypeptide binding]; other site
435590004233	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590004234	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590004235	nucleotide binding region [chemical binding]; other site
435590004236	ATP-binding site [chemical binding]; other site
435590004237	Helicase associated domain; Region: HA; pfam03457
435590004238	Helicase associated domain; Region: HA; pfam03457
435590004239	Helicase associated domain; Region: HA; pfam03457
435590004240	Helicase associated domain; Region: HA; pfam03457
435590004241	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590004242	dimer interface [polypeptide binding]; other site
435590004243	phosphorylation site [posttranslational modification]
435590004244	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590004245	ATP binding site [chemical binding]; other site
435590004246	Mg2+ binding site [ion binding]; other site
435590004247	G-X-G motif; other site
435590004248	Response regulator receiver domain; Region: Response_reg; pfam00072
435590004249	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590004250	active site
435590004251	phosphorylation site [posttranslational modification]
435590004252	intermolecular recognition site; other site
435590004253	dimerization interface [polypeptide binding]; other site
435590004254	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
435590004255	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590004256	active site
435590004257	phosphorylation site [posttranslational modification]
435590004258	intermolecular recognition site; other site
435590004259	dimerization interface [polypeptide binding]; other site
435590004260	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590004261	Walker A motif; other site
435590004262	ATP binding site [chemical binding]; other site
435590004263	Walker B motif; other site
435590004264	arginine finger; other site
435590004265	Helix-turn-helix domains; Region: HTH; cl00088
435590004266	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
435590004267	YWFCY protein; Region: YWFCY; pfam14293
435590004268	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
435590004269	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590004270	Walker B motif; other site
435590004271	Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584
435590004272	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
435590004273	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590004274	Protein of unknown function (DUF3408); Region: DUF3408; pfam11888
435590004275	Domain of unknown function (DUF4122); Region: DUF4122; pfam13498
435590004276	Domain of unknown function (DUF4134); Region: DUF4134; pfam13572
435590004277	Domain of unknown function (DUF4133); Region: DUF4133; pfam13571
435590004278	Bacteroides conjugation system ATPase, TraG family; Region: Bac_Flav_CT_G; TIGR03783
435590004279	Domain of unknown function, B. Theta Gene description (DUF3875); Region: DUF3875; pfam12991
435590004280	Domain of unknown function, B. Theta Gene description (DUF3876); Region: DUF3876; pfam12992
435590004281	Domain of unknown function (DUF4141); Region: DUF4141; pfam13605
435590004282	Bacteroides conjugative transposon TraJ protein; Region: Bac_Flav_CT_J; TIGR03782
435590004283	Bacteroides conjugative transposon TraK protein; Region: Bac_Flav_CT_K; TIGR03781
435590004284	Protein of unknown function (DUF3989); Region: DUF3989; pfam13150
435590004285	Bacteroides conjugative transposon TraM protein; Region: Bac_Flav_CT_M; TIGR03779
435590004286	Protein of unknown function (DUF3714); Region: DUF3714; pfam12508
435590004287	Bacteroides conjugative transposon TraN protein; Region: Bac_Flav_CT_N; TIGR03780
435590004288	Domain of unknown function (DUF4138); Region: DUF4138; pfam13595
435590004289	Conjugative transposon protein TraO; Region: TraO; pfam10626
435590004290	Domain of unknown function, B. Theta Gene description (DUF3872); Region: DUF3872; pfam12988
435590004291	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
435590004292	catalytic residue [active]
435590004293	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
435590004294	metal binding site [ion binding]; metal-binding site
435590004295	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
435590004296	Domain of unknown function (DUF4121); Region: DUF4121; pfam13497
435590004297	Domain of unknown function (DUF4120); Region: DUF4120; pfam13496
435590004298	DnaJ_C chaperone protein; Provisional; Region: PTZ00037
435590004299	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
435590004300	Domain of unknown function (DUF4313); Region: DUF4313; pfam14190
435590004301	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
435590004302	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590004303	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
435590004304	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590004305	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590004306	Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185
435590004307	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
435590004308	Int/Topo IB signature motif; other site
435590004309	thiamine-monophosphate kinase; Region: thiL; TIGR01379
435590004310	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
435590004311	ATP binding site [chemical binding]; other site
435590004312	dimerization interface [polypeptide binding]; other site
435590004313	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
435590004314	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652
435590004315	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
435590004316	signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705
435590004317	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
435590004318	tandem repeat interface [polypeptide binding]; other site
435590004319	oligomer interface [polypeptide binding]; other site
435590004320	active site residues [active]
435590004321	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
435590004322	tandem repeat interface [polypeptide binding]; other site
435590004323	oligomer interface [polypeptide binding]; other site
435590004324	active site residues [active]
435590004325	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
435590004326	dimer interface [polypeptide binding]; other site
435590004327	FMN binding site [chemical binding]; other site
435590004328	bifunctional fucokinase/L-fucose-1-P-guanylyltransferase; Provisional; Region: fkp; PRK13412
435590004329	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
435590004330	Glycerate kinase family; Region: Gly_kinase; cl00841
435590004331	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
435590004332	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
435590004333	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
435590004334	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
435590004335	Gram-negative bacterial tonB protein; Region: TonB; cl10048
435590004336	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
435590004337	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
435590004338	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590004339	binding surface
435590004340	TPR motif; other site
435590004341	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
435590004342	binding surface
435590004343	TPR motif; other site
435590004344	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
435590004345	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
435590004346	Walker A/P-loop; other site
435590004347	ATP binding site [chemical binding]; other site
435590004348	Q-loop/lid; other site
435590004349	ABC transporter signature motif; other site
435590004350	Walker B; other site
435590004351	D-loop; other site
435590004352	H-loop/switch region; other site
435590004353	Predicted transcriptional regulators [Transcription]; Region: COG1725
435590004354	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
435590004355	DNA-binding site [nucleotide binding]; DNA binding site
435590004356	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
435590004357	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
435590004358	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
435590004359	metal binding site [ion binding]; metal-binding site
435590004360	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
435590004361	MatE; Region: MatE; cl10513
435590004362	MatE; Region: MatE; cl10513
435590004363	adenylosuccinate lyase; Provisional; Region: PRK09285
435590004364	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
435590004365	tetramer interface [polypeptide binding]; other site
435590004366	active site
435590004367	Spumavirus gag protein; Region: Gag_spuma; pfam03276
435590004368	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
435590004369	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
435590004370	RNA binding surface [nucleotide binding]; other site
435590004371	Pseudouridine synthases  are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870
435590004372	active site
435590004373	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
435590004374	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
435590004375	putative dimer interface [polypeptide binding]; other site
435590004376	putative anticodon binding site; other site
435590004377	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
435590004378	homodimer interface [polypeptide binding]; other site
435590004379	motif 1; other site
435590004380	motif 2; other site
435590004381	active site
435590004382	motif 3; other site
435590004383	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590004384	AAA domain; Region: AAA_33; pfam13671
435590004385	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
435590004386	23S rRNA interface [nucleotide binding]; other site
435590004387	L3 interface [polypeptide binding]; other site
435590004388	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
435590004389	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
435590004390	rRNA interaction site [nucleotide binding]; other site
435590004391	S8 interaction site; other site
435590004392	putative laminin-1 binding site; other site
435590004393	elongation factor Ts; Provisional; Region: tsf; PRK09377
435590004394	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
435590004395	Elongation factor TS; Region: EF_TS; pfam00889
435590004396	Elongation factor TS; Region: EF_TS; pfam00889
435590004397	The SUI1/eIF1 (eukaryotic initiation factor 1) fold is found in eukaryotes, archaea, and some bacteria and is thought to play an important role in accurate initiator codon recognition during translation initiation. This fold, which includes two...; Region: SUI1_eIF1; cl00229
435590004398	Predicted RNA interaction site [nucleotide binding]; other site
435590004399	putative binding site; other site
435590004400	Mutations affecting start-site selection; other site
435590004401	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
435590004402	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
435590004403	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590004404	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
435590004405	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
435590004406	homotrimer interaction site [polypeptide binding]; other site
435590004407	zinc binding site [ion binding]; other site
435590004408	CDP-binding sites; other site
435590004409	UbiA prenyltransferase family; Region: UbiA; cl00337
435590004410	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
435590004411	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
435590004412	putative active site [active]
435590004413	putative metal binding site [ion binding]; other site
435590004414	Family of unknown function (DUF3836); Region: DUF3836; pfam12930
435590004415	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
435590004416	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
435590004417	active site
435590004418	(T/H)XGH motif; other site
435590004419	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
435590004420	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
435590004421	catalytic site [active]
435590004422	G-X2-G-X-G-K; other site
435590004423	hypothetical protein; Provisional; Region: PRK11820
435590004424	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
435590004425	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
435590004426	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
435590004427	Domain of unknown function (DUF4290); Region: DUF4290; pfam14123
435590004428	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
435590004429	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
435590004430	hinge; other site
435590004431	active site
435590004432	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
435590004433	RimM N-terminal domain; Region: RimM; pfam01782
435590004434	Peptidase family M23; Region: Peptidase_M23; pfam01551
435590004435	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
435590004436	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
435590004437	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
435590004438	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
435590004439	RIP metalloprotease RseP; Region: TIGR00054
435590004440	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
435590004441	active site
435590004442	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
435590004443	protein binding site [polypeptide binding]; other site
435590004444	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
435590004445	putative substrate binding region [chemical binding]; other site
435590004446	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
435590004447	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111
435590004448	ATP cone domain; Region: ATP-cone; pfam03477
435590004449	Class III ribonucleotide reductase; Region: RNR_III; cd01675
435590004450	effector binding site; other site
435590004451	active site
435590004452	Zn binding site [ion binding]; other site
435590004453	glycine loop; other site
435590004454	Haemolysin-III related; Region: HlyIII; cl03831
435590004455	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
435590004456	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
435590004457	active site
435590004458	NTP binding site [chemical binding]; other site
435590004459	metal binding triad [ion binding]; metal-binding site
435590004460	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
435590004461	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
435590004462	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
435590004463	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
435590004464	RuvA N terminal domain; Region: RuvA_N; pfam01330
435590004465	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
435590004466	diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921
435590004467	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590004468	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
435590004469	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
435590004470	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590004471	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
435590004472	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
435590004473	substrate binding [chemical binding]; other site
435590004474	active site
435590004475	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
435590004476	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
435590004477	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590004478	putative substrate translocation pore; other site
435590004479	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
435590004480	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
435590004481	putative substrate binding site [chemical binding]; other site
435590004482	putative ATP binding site [chemical binding]; other site
435590004483	Periplasmic binding domain of two-component sensor kinase signaling systems; Region: PBP1_sensor_kinase_like; cd06308
435590004484	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
435590004485	putative ligand binding site [chemical binding]; other site
435590004486	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590004487	dimer interface [polypeptide binding]; other site
435590004488	phosphorylation site [posttranslational modification]
435590004489	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
435590004490	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590004491	ATP binding site [chemical binding]; other site
435590004492	Mg2+ binding site [ion binding]; other site
435590004493	G-X-G motif; other site
435590004494	Response regulator receiver domain; Region: Response_reg; pfam00072
435590004495	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590004496	active site
435590004497	phosphorylation site [posttranslational modification]
435590004498	intermolecular recognition site; other site
435590004499	dimerization interface [polypeptide binding]; other site
435590004500	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590004501	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590004502	ACT domain-containing protein [General function prediction only]; Region: COG4747
435590004503	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
435590004504	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
435590004505	AMP-binding enzyme; Region: AMP-binding; cl15778
435590004506	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
435590004507	Protein of unknown function (DUF3256); Region: DUF3256; pfam11644
435590004508	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
435590004509	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
435590004510	hypothetical protein; Provisional; Region: PRK08185
435590004511	intersubunit interface [polypeptide binding]; other site
435590004512	active site
435590004513	zinc binding site [ion binding]; other site
435590004514	Na+ binding site [ion binding]; other site
435590004515	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590004516	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590004517	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
435590004518	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
435590004519	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
435590004520	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
435590004521	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
435590004522	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
435590004523	Domain of unknown function (DUF3332); Region: DUF3332; pfam11810
435590004524	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590004525	Major Facilitator Superfamily; Region: MFS_1; pfam07690
435590004526	putative substrate translocation pore; other site
435590004527	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
435590004528	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
435590004529	putative substrate binding site [chemical binding]; other site
435590004530	putative ATP binding site [chemical binding]; other site
435590004531	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
435590004532	active site
435590004533	adenylate kinase; Reviewed; Region: adk; PRK00279
435590004534	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
435590004535	AMP-binding site [chemical binding]; other site
435590004536	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
435590004537	GTPase CgtA; Reviewed; Region: obgE; PRK12298
435590004538	GTP1/OBG; Region: GTP1_OBG; pfam01018
435590004539	Obg GTPase; Region: Obg; cd01898
435590004540	G1 box; other site
435590004541	GTP/Mg2+ binding site [chemical binding]; other site
435590004542	Switch I region; other site
435590004543	G2 box; other site
435590004544	G3 box; other site
435590004545	Switch II region; other site
435590004546	G4 box; other site
435590004547	G5 box; other site
435590004548	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
435590004549	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
435590004550	B3/4 domain; Region: B3_4; cl11458
435590004551	Peptidase family M23; Region: Peptidase_M23; pfam01551
435590004552	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
435590004553	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
435590004554	Transposase; Region: DDE_Tnp_ISL3; pfam01610
435590004555	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
435590004556	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
435590004557	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
435590004558	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
435590004559	tetramer interface [polypeptide binding]; other site
435590004560	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590004561	catalytic residue [active]
435590004562	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590004563	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
435590004564	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
435590004565	N-terminal plug; other site
435590004566	ligand-binding site [chemical binding]; other site
435590004567	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
435590004568	Phosphomannose isomerase type I; Region: PMI_typeI; cl15429
435590004569	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
435590004570	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
435590004571	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
435590004572	Domain of unknown function, B. Theta Gene description (DUF3871); Region: DUF3871; pfam12987
435590004573	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590004574	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590004575	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590004576	DNA binding residues [nucleotide binding]
435590004577	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
435590004578	FecR protein; Region: FecR; pfam04773
435590004579	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590004580	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590004581	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590004582	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590004583	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590004584	Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566
435590004585	putative active site [active]
435590004586	catalytic site [active]
435590004587	putative metal binding site [ion binding]; other site
435590004588	oligomer interface [polypeptide binding]; other site
435590004589	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
435590004590	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
435590004591	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
435590004592	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
435590004593	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
435590004594	Integrase core domain; Region: rve; cl01316
435590004595	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
435590004596	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
435590004597	MatE; Region: MatE; cl10513
435590004598	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
435590004599	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
435590004600	metal-binding site
435590004601	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590004602	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
435590004603	putative ADP-binding pocket [chemical binding]; other site
435590004604	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
435590004605	Core-2/I-Branching enzyme; Region: Branch; pfam02485
435590004606	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
435590004607	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
435590004608	active site
435590004609	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
435590004610	Mg++ binding site [ion binding]; other site
435590004611	putative catalytic motif [active]
435590004612	substrate binding site [chemical binding]; other site
435590004613	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
435590004614	VirE N-terminal domain; Region: VirE_N; pfam08800
435590004615	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
435590004616	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
435590004617	Protein of unknown function (DUF3853); Region: DUF3853; pfam12964
435590004618	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
435590004619	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590004620	DNA binding site [nucleotide binding]
435590004621	Int/Topo IB signature motif; other site
435590004622	active site
435590004623	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
435590004624	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
435590004625	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590004626	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
435590004627	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
435590004628	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
435590004629	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590004630	Mg2+ binding site [ion binding]; other site
435590004631	G-X-G motif; other site
435590004632	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
435590004633	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
435590004634	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
435590004635	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
435590004636	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
435590004637	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
435590004638	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
435590004639	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
435590004640	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
435590004641	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
435590004642	NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634
435590004643	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
435590004644	4Fe-4S binding domain; Region: Fer4; cl02805
435590004645	4Fe-4S binding domain; Region: Fer4; cl02805
435590004646	NADH dehydrogenase; Region: NADHdh; cl00469
435590004647	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
435590004648	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771
435590004649	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
435590004650	NADH dehydrogenase subunit B; Provisional; Region: PRK14816
435590004651	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
435590004652	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
435590004653	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
435590004654	Cation transport protein; Region: TrkH; cl10514
435590004655	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
435590004656	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590004657	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
435590004658	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590004659	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
435590004660	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
435590004661	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
435590004662	TPP-binding site; other site
435590004663	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
435590004664	PYR/PP interface [polypeptide binding]; other site
435590004665	dimer interface [polypeptide binding]; other site
435590004666	TPP binding site [chemical binding]; other site
435590004667	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
435590004668	GSCFA family; Region: GSCFA; pfam08885
435590004669	putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional; Region: PRK11930
435590004670	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
435590004671	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
435590004672	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
435590004673	active site
435590004674	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
435590004675	dimer interface [polypeptide binding]; other site
435590004676	substrate binding site [chemical binding]; other site
435590004677	catalytic residues [active]
435590004678	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
435590004679	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
435590004680	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590004681	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
435590004682	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
435590004683	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
435590004684	active site
435590004685	catalytic triad [active]
435590004686	oxyanion hole [active]
435590004687	Sulfatase; Region: Sulfatase; cl10460
435590004688	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590004689	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590004690	Secretin and TonB N terminus short domain; Region: STN; cl06624
435590004691	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590004692	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590004693	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590004694	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590004695	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590004696	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
435590004697	FecR protein; Region: FecR; pfam04773
435590004698	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590004699	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590004700	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590004701	DNA binding residues [nucleotide binding]
435590004702	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
435590004703	Virulence-associated protein E; Region: VirE; pfam05272
435590004704	Domain of unknonw function from B. Theta Gene description (DUF3874); Region: DUF3874; pfam12990
435590004705	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590004706	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590004707	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590004708	DNA binding residues [nucleotide binding]
435590004709	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
435590004710	FecR protein; Region: FecR; pfam04773
435590004711	Secretin and TonB N terminus short domain; Region: STN; cl06624
435590004712	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590004713	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590004714	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590004715	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590004716	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590004717	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590004718	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
435590004719	Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752
435590004720	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
435590004721	beta-D-glucuronidase; Provisional; Region: PRK10150
435590004722	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590004723	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
435590004724	Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721
435590004725	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801
435590004726	Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257
435590004727	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590004728	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590004729	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
435590004730	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590004731	Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088
435590004732	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
435590004733	NAD binding site [chemical binding]; other site
435590004734	catalytic residues [active]
435590004735	substrate binding site [chemical binding]; other site
435590004736	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
435590004737	active site
435590004738	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
435590004739	Putative collagen-binding domain of a collagenase; Region: Collagen_bind_2; pfam12904
435590004740	DNA helicase, putative; Region: TIGR00376
435590004741	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590004742	Family description; Region: UvrD_C_2; cl15862
435590004743	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590004744	putative substrate translocation pore; other site
435590004745	KduI/IolB family; Region: KduI; cl01508
435590004746	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
435590004747	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
435590004748	Pectinesterase; Region: Pectinesterase; cl01911
435590004749	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590004750	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590004751	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590004752	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590004753	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590004754	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590004755	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
435590004756	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
435590004757	BNR repeat-like domain; Region: BNR_2; pfam13088
435590004758	catalytic site [active]
435590004759	Asp-box motif; other site
435590004760	Pectinesterase; Region: Pectinesterase; cl01911
435590004761	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590004762	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590004763	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590004764	DNA binding residues [nucleotide binding]
435590004765	FecR protein; Region: FecR; pfam04773
435590004766	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
435590004767	Secretin and TonB N terminus short domain; Region: STN; cl06624
435590004768	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590004769	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590004770	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590004771	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590004772	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590004773	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
435590004774	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590004775	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
435590004776	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
435590004777	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590004778	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
435590004779	PA14 domain; Region: PA14; cl08459
435590004780	putative alpha-glucosidase; Provisional; Region: PRK10658
435590004781	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
435590004782	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
435590004783	active site
435590004784	catalytic site [active]
435590004785	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
435590004786	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
435590004787	Cupin domain; Region: Cupin_2; cl09118
435590004788	Pectic acid lyase; Region: Pec_lyase; pfam09492
435590004789	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
435590004790	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
435590004791	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
435590004792	active site
435590004793	catalytic triad [active]
435590004794	Pectinesterase; Region: Pectinesterase; cl01911
435590004795	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590004796	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590004797	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590004798	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590004799	dimer interface [polypeptide binding]; other site
435590004800	phosphorylation site [posttranslational modification]
435590004801	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590004802	ATP binding site [chemical binding]; other site
435590004803	Mg2+ binding site [ion binding]; other site
435590004804	G-X-G motif; other site
435590004805	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590004806	Response regulator receiver domain; Region: Response_reg; pfam00072
435590004807	active site
435590004808	phosphorylation site [posttranslational modification]
435590004809	intermolecular recognition site; other site
435590004810	dimerization interface [polypeptide binding]; other site
435590004811	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590004812	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590004813	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
435590004814	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
435590004815	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
435590004816	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
435590004817	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
435590004818	Phosphate transporter family; Region: PHO4; cl00396
435590004819	Phosphate transporter family; Region: PHO4; cl00396
435590004820	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
435590004821	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
435590004822	purine monophosphate binding site [chemical binding]; other site
435590004823	dimer interface [polypeptide binding]; other site
435590004824	putative catalytic residues [active]
435590004825	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
435590004826	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
435590004827	rod shape-determining protein MreB; Provisional; Region: PRK13927
435590004828	Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528
435590004829	ATP binding site [chemical binding]; other site
435590004830	Cell division protein FtsA; Region: FtsA; cl11496
435590004831	rod shape-determining protein MreC; Provisional; Region: PRK13922
435590004832	rod shape-determining protein MreC; Region: MreC; pfam04085
435590004833	rod shape-determining protein MreD; Region: MreD; cl01087
435590004834	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
435590004835	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
435590004836	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
435590004837	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
435590004838	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
435590004839	GldH lipoprotein; Region: GldH_lipo; cl11905
435590004840	PSP1 C-terminal conserved region; Region: PSP1; cl00770
435590004841	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590004842	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
435590004843	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590004844	DNA polymerase III subunit delta'; Validated; Region: PRK05564
435590004845	Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219
435590004846	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
435590004847	FAD binding site [chemical binding]; other site
435590004848	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
435590004849	PLD-like domain; Region: PLDc_2; pfam13091
435590004850	putative active site [active]
435590004851	catalytic site [active]
435590004852	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
435590004853	PLD-like domain; Region: PLDc_2; pfam13091
435590004854	putative active site [active]
435590004855	catalytic site [active]
435590004856	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
435590004857	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
435590004858	thymidine kinase; Provisional; Region: PRK04296
435590004859	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
435590004860	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
435590004861	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
435590004862	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cl00148
435590004863	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
435590004864	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
435590004865	motif II; other site
435590004866	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590004867	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590004868	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590004869	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590004870	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590004871	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
435590004872	DNA binding site [nucleotide binding]
435590004873	Int/Topo IB signature motif; other site
435590004874	active site
435590004875	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590004876	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590004877	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590004878	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590004879	HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]; Region: HRD1; COG5243
435590004880	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590004881	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590004882	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590004883	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590004884	Transposase domain (DUF772); Region: DUF772; cl15789
435590004885	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590004886	Transposase domain (DUF772); Region: DUF772; cl15789
435590004887	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590004888	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590004889	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590004890	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590004891	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590004892	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590004893	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590004894	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590004895	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590004896	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590004897	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590004898	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590004899	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590004900	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590004901	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590004902	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
435590004903	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
435590004904	HflX GTPase family; Region: HflX; cd01878
435590004905	G1 box; other site
435590004906	GTP/Mg2+ binding site [chemical binding]; other site
435590004907	Switch I region; other site
435590004908	G2 box; other site
435590004909	G3 box; other site
435590004910	Switch II region; other site
435590004911	G4 box; other site
435590004912	G5 box; other site
435590004913	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
435590004914	putative trimer interface [polypeptide binding]; other site
435590004915	putative CoA binding site [chemical binding]; other site
435590004916	Predicted acyl esterases [General function prediction only]; Region: COG2936
435590004917	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
435590004918	fumarate hydratase; Provisional; Region: PRK15389
435590004919	Fumarate hydratase (Fumerase); Region: Fumerase; cl00851
435590004920	Fumarase C-terminus; Region: Fumerase_C; cl00795
435590004921	Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971
435590004922	Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089
435590004923	Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972
435590004924	amino acid transporter; Region: 2A0306; TIGR00909
435590004925	Spore germination protein; Region: Spore_permease; cl15802
435590004926	Spore germination protein; Region: Spore_permease; cl15802
435590004927	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
435590004928	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
435590004929	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
435590004930	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
435590004931	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
435590004932	M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663
435590004933	metal binding site [ion binding]; metal-binding site
435590004934	GTPase RsgA; Reviewed; Region: PRK00098
435590004935	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
435590004936	RNA binding site [nucleotide binding]; other site
435590004937	homodimer interface [polypeptide binding]; other site
435590004938	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
435590004939	GTPase/Zn-binding domain interface [polypeptide binding]; other site
435590004940	GTP/Mg2+ binding site [chemical binding]; other site
435590004941	G4 box; other site
435590004942	G5 box; other site
435590004943	G1 box; other site
435590004944	Switch I region; other site
435590004945	G2 box; other site
435590004946	G3 box; other site
435590004947	Switch II region; other site
435590004948	ribosome recycling factor; Reviewed; Region: frr; PRK00083
435590004949	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
435590004950	hinge region; other site
435590004951	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
435590004952	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
435590004953	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
435590004954	catalytic core [active]
435590004955	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801
435590004956	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
435590004957	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
435590004958	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
435590004959	putative nucleotide binding site [chemical binding]; other site
435590004960	uridine monophosphate binding site [chemical binding]; other site
435590004961	homohexameric interface [polypeptide binding]; other site
435590004962	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
435590004963	MatE; Region: MatE; cl10513
435590004964	MatE; Region: MatE; cl10513
435590004965	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
435590004966	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
435590004967	C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561
435590004968	Catalytic dyad [active]
435590004969	Transposase domain (DUF772); Region: DUF772; cl15789
435590004970	Transposase domain (DUF772); Region: DUF772; cl15789
435590004971	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
435590004972	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
435590004973	Protein of unknown function (DUF419); Region: DUF419; cl15265
435590004974	Restriction endonuclease; Region: Mrr_cat; cl00516
435590004975	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
435590004976	nucleoside/Zn binding site; other site
435590004977	dimer interface [polypeptide binding]; other site
435590004978	catalytic motif [active]
435590004979	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
435590004980	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
435590004981	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
435590004982	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
435590004983	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
435590004984	generic binding surface II; other site
435590004985	generic binding surface I; other site
435590004986	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
435590004987	catalytic residues [active]
435590004988	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
435590004989	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
435590004990	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
435590004991	ABC-ATPase subunit  interface; other site
435590004992	dimer interface [polypeptide binding]; other site
435590004993	putative PBP binding regions; other site
435590004994	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
435590004995	3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356
435590004996	hinge; other site
435590004997	active site
435590004998	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
435590004999	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
435590005000	putative active site; other site
435590005001	catalytic residue [active]
435590005002	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
435590005003	catalytic core [active]
435590005004	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
435590005005	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
435590005006	DNA polymerase IV; Validated; Region: PRK02406
435590005007	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
435590005008	active site
435590005009	DNA binding site [nucleotide binding]
435590005010	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590005011	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
435590005012	active site
435590005013	dimer interface [polypeptide binding]; other site
435590005014	metal binding site [ion binding]; metal-binding site
435590005015	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590005016	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590005017	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
435590005018	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
435590005019	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
435590005020	putative active site [active]
435590005021	catalytic site [active]
435590005022	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
435590005023	putative active site [active]
435590005024	catalytic site [active]
435590005025	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590005026	S-adenosylmethionine binding site [chemical binding]; other site
435590005027	Protein of unknown function (DUF3822); Region: DUF3822; pfam12864
435590005028	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590005029	Family description; Region: UvrD_C_2; cl15862
435590005030	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
435590005031	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673
435590005032	motif 1; other site
435590005033	active site
435590005034	motif 2; other site
435590005035	motif 3; other site
435590005036	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
435590005037	DHHA1 domain; Region: DHHA1; pfam02272
435590005038	Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219
435590005039	Peptidase family M23; Region: Peptidase_M23; pfam01551
435590005040	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
435590005041	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
435590005042	DNA binding residues [nucleotide binding]
435590005043	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
435590005044	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
435590005045	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
435590005046	synthetase active site [active]
435590005047	NTP binding site [chemical binding]; other site
435590005048	metal binding site [ion binding]; metal-binding site
435590005049	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
435590005050	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
435590005051	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
435590005052	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
435590005053	N-acetyl-D-glucosamine binding site [chemical binding]; other site
435590005054	catalytic residue [active]
435590005055	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
435590005056	putative peptidoglycan binding site; other site
435590005057	ParB-like partition proteins; Region: parB_part; TIGR00180
435590005058	ParB-like nuclease domain; Region: ParBc; cl02129
435590005059	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
435590005060	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
435590005061	P-loop; other site
435590005062	Magnesium ion binding site [ion binding]; other site
435590005063	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
435590005064	Magnesium ion binding site [ion binding]; other site
435590005065	Survival protein SurE; Region: SurE; cl00448
435590005066	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
435590005067	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
435590005068	NigD-like protein; Region: NigD; pfam12667
435590005069	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
435590005070	FtsH Extracellular; Region: FtsH_ext; pfam06480
435590005071	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
435590005072	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590005073	Walker A motif; other site
435590005074	ATP binding site [chemical binding]; other site
435590005075	Walker B motif; other site
435590005076	arginine finger; other site
435590005077	Peptidase family M41; Region: Peptidase_M41; pfam01434
435590005078	Oligomerisation domain; Region: Oligomerisation; cl00519
435590005079	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
435590005080	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
435590005081	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
435590005082	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
435590005083	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
435590005084	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
435590005085	MgtE intracellular N domain; Region: MgtE_N; cl15244
435590005086	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
435590005087	Divalent cation transporter; Region: MgtE; cl00786
435590005088	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590005089	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
435590005090	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
435590005091	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
435590005092	metal binding site [ion binding]; metal-binding site
435590005093	dimer interface [polypeptide binding]; other site
435590005094	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
435590005095	nucleoside/Zn binding site; other site
435590005096	dimer interface [polypeptide binding]; other site
435590005097	catalytic motif [active]
435590005098	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
435590005099	non-specific DNA binding site [nucleotide binding]; other site
435590005100	salt bridge; other site
435590005101	sequence-specific DNA binding site [nucleotide binding]; other site
435590005102	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
435590005103	MG2 domain; Region: A2M_N; pfam01835
435590005104	Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703
435590005105	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
435590005106	Alpha-2-macroglobulin family; Region: A2M; pfam00207
435590005107	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
435590005108	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
435590005109	membrane ATPase/protein kinase; Provisional; Region: PRK09435
435590005110	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
435590005111	Walker A; other site
435590005112	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590005113	G4 box; other site
435590005114	G5 box; other site
435590005115	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
435590005116	active site
435590005117	ADP/pyrophosphate binding site [chemical binding]; other site
435590005118	dimerization interface [polypeptide binding]; other site
435590005119	allosteric effector site; other site
435590005120	fructose-1,6-bisphosphate binding site; other site
435590005121	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
435590005122	LytB protein; Region: LYTB; cl00507
435590005123	cytidylate kinase; Provisional; Region: cmk; PRK00023
435590005124	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590005125	active site
435590005126	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
435590005127	CMP-binding site; other site
435590005128	The sites determining sugar specificity; other site
435590005129	Gram-negative bacterial tonB protein; Region: TonB; cl10048
435590005130	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
435590005131	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
435590005132	substrate binding pocket [chemical binding]; other site
435590005133	chain length determination region; other site
435590005134	substrate-Mg2+ binding site; other site
435590005135	catalytic residues [active]
435590005136	aspartate-rich region 1; other site
435590005137	active site lid residues [active]
435590005138	aspartate-rich region 2; other site
435590005139	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
435590005140	active site
435590005141	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
435590005142	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
435590005143	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
435590005144	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
435590005145	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
435590005146	Coenzyme A binding pocket [chemical binding]; other site
435590005147	IgA Peptidase M64; Region: Peptidase_M64; pfam09471
435590005148	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
435590005149	Helix-turn-helix domains; Region: HTH; cl00088
435590005150	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
435590005151	folate binding site [chemical binding]; other site
435590005152	NADP+ binding site [chemical binding]; other site
435590005153	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
435590005154	dimerization interface [polypeptide binding]; other site
435590005155	active site
435590005156	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
435590005157	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590005158	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590005159	DNA binding residues [nucleotide binding]
435590005160	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
435590005161	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
435590005162	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; cl01283
435590005163	DNA topoisomerase III; Provisional; Region: PRK07726
435590005164	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
435590005165	active site
435590005166	putative interdomain interaction site [polypeptide binding]; other site
435590005167	putative metal-binding site [ion binding]; other site
435590005168	putative nucleotide binding site [chemical binding]; other site
435590005169	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
435590005170	domain I; other site
435590005171	phosphate binding site [ion binding]; other site
435590005172	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
435590005173	domain II; other site
435590005174	domain III; other site
435590005175	nucleotide binding site [chemical binding]; other site
435590005176	DNA binding groove [nucleotide binding]
435590005177	catalytic site [active]
435590005178	domain IV; other site
435590005179	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
435590005180	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
435590005181	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
435590005182	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
435590005183	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590005184	Family description; Region: UvrD_C_2; cl15862
435590005185	aconitate hydratase; Validated; Region: PRK07229
435590005186	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
435590005187	substrate binding site [chemical binding]; other site
435590005188	ligand binding site [chemical binding]; other site
435590005189	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
435590005190	substrate binding site [chemical binding]; other site
435590005191	isocitrate dehydrogenase; Validated; Region: PRK06451
435590005192	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
435590005193	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
435590005194	Citrate synthase; Region: Citrate_synt; pfam00285
435590005195	oxalacetate binding site [chemical binding]; other site
435590005196	citrylCoA binding site [chemical binding]; other site
435590005197	coenzyme A binding site [chemical binding]; other site
435590005198	catalytic triad [active]
435590005199	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
435590005200	Coenzyme A binding pocket [chemical binding]; other site
435590005201	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
435590005202	Phospholipid methyltransferase; Region: PEMT; cl00763
435590005203	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
435590005204	active site
435590005205	FMN binding site [chemical binding]; other site
435590005206	substrate binding site [chemical binding]; other site
435590005207	putative catalytic residue [active]
435590005208	short chain dehydrogenase; Provisional; Region: PRK06197
435590005209	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
435590005210	putative NAD(P) binding site [chemical binding]; other site
435590005211	active site
435590005212	EamA-like transporter family; Region: EamA; cl01037
435590005213	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
435590005214	EamA-like transporter family; Region: EamA; cl01037
435590005215	AAA domain; Region: AAA_21; pfam13304
435590005216	ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules.  The...; Region: ABC_ATPase; cd00267
435590005217	Q-loop/lid; other site
435590005218	ABC transporter signature motif; other site
435590005219	Walker B; other site
435590005220	D-loop; other site
435590005221	H-loop/switch region; other site
435590005222	DoxX; Region: DoxX; cl00976
435590005223	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
435590005224	active site
435590005225	ADP/pyrophosphate binding site [chemical binding]; other site
435590005226	dimerization interface [polypeptide binding]; other site
435590005227	allosteric effector site; other site
435590005228	fructose-1,6-bisphosphate binding site; other site
435590005229	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
435590005230	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
435590005231	motif II; other site
435590005232	Nitroreductase-like family 3. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_3; cd02139
435590005233	putative FMN binding site [chemical binding]; other site
435590005234	Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; cl01458
435590005235	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
435590005236	oxaloacetate decarboxylase alpha subunit; Region: oadA; TIGR01108
435590005237	active site
435590005238	catalytic residues [active]
435590005239	metal binding site [ion binding]; metal-binding site
435590005240	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
435590005241	carboxyltransferase (CT) interaction site; other site
435590005242	biotinylation site [posttranslational modification]; other site
435590005243	Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816
435590005244	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
435590005245	catalytic residues [active]
435590005246	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
435590005247	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590005248	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590005249	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590005250	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590005251	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590005252	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590005253	FecR protein; Region: FecR; pfam04773
435590005254	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
435590005255	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590005256	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590005257	DNA binding residues [nucleotide binding]
435590005258	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
435590005259	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001
435590005260	active site
435590005261	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
435590005262	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
435590005263	Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561
435590005264	NAD binding site [chemical binding]; other site
435590005265	homotetramer interface [polypeptide binding]; other site
435590005266	homodimer interface [polypeptide binding]; other site
435590005267	substrate binding site [chemical binding]; other site
435590005268	active site
435590005269	gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514
435590005270	Predicted methyltransferases [General function prediction only]; Region: COG0313
435590005271	lipoyl synthase; Provisional; Region: PRK05481
435590005272	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590005273	FeS/SAM binding site; other site
435590005274	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
435590005275	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
435590005276	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
435590005277	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
435590005278	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
435590005279	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
435590005280	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
435590005281	Conserved TM helix; Region: TM_helix; pfam05552
435590005282	Mechanosensitive ion channel; Region: MS_channel; pfam00924
435590005283	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
435590005284	PIF1-like helicase; Region: PIF1; pfam05970
435590005285	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590005286	conjugal transfer relaxase TraA; Provisional; Region: PRK13889
435590005287	Family description; Region: UvrD_C_2; cl15862
435590005288	TPR repeat; Region: TPR_11; pfam13414
435590005289	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590005290	binding surface
435590005291	TPR motif; other site
435590005292	TPR repeat; Region: TPR_11; pfam13414
435590005293	Tetratricopeptide repeat; Region: TPR_16; pfam13432
435590005294	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
435590005295	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
435590005296	2-isopropylmalate synthase; Validated; Region: PRK00915
435590005297	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
435590005298	active site
435590005299	catalytic residues [active]
435590005300	metal binding site [ion binding]; metal-binding site
435590005301	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
435590005302	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
435590005303	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
435590005304	substrate binding site [chemical binding]; other site
435590005305	ligand binding site [chemical binding]; other site
435590005306	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
435590005307	substrate binding site [chemical binding]; other site
435590005308	(R)-citramalate synthase; Provisional; Region: PRK09389
435590005309	Leptospira interrogans citramalate synthase (CMS) and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_CMS; cd07945
435590005310	active site
435590005311	catalytic residues [active]
435590005312	metal binding site [ion binding]; metal-binding site
435590005313	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
435590005314	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
435590005315	tartrate dehydrogenase; Provisional; Region: PRK08194
435590005316	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
435590005317	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
435590005318	catalytic residues [active]
435590005319	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
435590005320	TPR repeat; Region: TPR_11; pfam13414
435590005321	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590005322	binding surface
435590005323	TPR motif; other site
435590005324	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590005325	binding surface
435590005326	TPR repeat; Region: TPR_11; pfam13414
435590005327	TPR motif; other site
435590005328	Transposase domain (DUF772); Region: DUF772; cl15789
435590005329	Transposase domain (DUF772); Region: DUF772; cl15789
435590005330	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
435590005331	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590005332	ATP binding site [chemical binding]; other site
435590005333	putative Mg++ binding site [ion binding]; other site
435590005334	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590005335	nucleotide binding region [chemical binding]; other site
435590005336	ATP-binding site [chemical binding]; other site
435590005337	RQC domain; Region: RQC; cl09632
435590005338	HRDC domain; Region: HRDC; cl02578
435590005339	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590005340	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590005341	Peptidase family M49; Region: Peptidase_M49; pfam03571
435590005342	A new structural DNA glycosylase; Region: AlkD_like; cd06561
435590005343	active site
435590005344	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
435590005345	metal binding site 2 [ion binding]; metal-binding site
435590005346	putative DNA binding helix; other site
435590005347	metal binding site 1 [ion binding]; metal-binding site
435590005348	dimer interface [polypeptide binding]; other site
435590005349	structural Zn2+ binding site [ion binding]; other site
435590005350	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
435590005351	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
435590005352	GDP-binding site [chemical binding]; other site
435590005353	ACT binding site; other site
435590005354	IMP binding site; other site
435590005355	Domain of unknown function (DUF4373); Region: DUF4373; pfam14297
435590005356	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590005357	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590005358	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590005359	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590005360	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
435590005361	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590005362	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590005363	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
435590005364	active site
435590005365	catalytic triad [active]
435590005366	oxyanion hole [active]
435590005367	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
435590005368	oxyanion hole [active]
435590005369	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590005370	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590005371	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
435590005372	FecR protein; Region: FecR; pfam04773
435590005373	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
435590005374	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590005375	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590005376	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590005377	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590005378	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590005379	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590005380	Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251
435590005381	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
435590005382	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
435590005383	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
435590005384	ABC transporter; Region: ABC_tran_2; pfam12848
435590005385	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
435590005386	Snf7; Region: Snf7; cl02305
435590005387	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
435590005388	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
435590005389	active site
435590005390	Zn binding site [ion binding]; other site
435590005391	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
435590005392	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
435590005393	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
435590005394	Protein export membrane protein; Region: SecD_SecF; cl14618
435590005395	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
435590005396	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
435590005397	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
435590005398	potential catalytic triad [active]
435590005399	conserved cys residue [active]
435590005400	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
435590005401	dimer interface [polypeptide binding]; other site
435590005402	FMN binding site [chemical binding]; other site
435590005403	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
435590005404	dimer interface [polypeptide binding]; other site
435590005405	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
435590005406	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590005407	homoserine O-succinyltransferase; Provisional; Region: PRK05368
435590005408	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
435590005409	proposed active site lysine [active]
435590005410	conserved cys residue [active]
435590005411	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
435590005412	Peptidase family U32; Region: Peptidase_U32; cl03113
435590005413	Collagenase; Region: DUF3656; pfam12392
435590005414	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
435590005415	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
435590005416	N-terminal plug; other site
435590005417	ligand-binding site [chemical binding]; other site
435590005418	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
435590005419	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
435590005420	DNA binding residues [nucleotide binding]
435590005421	dimerization interface [polypeptide binding]; other site
435590005422	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
435590005423	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590005424	Protein of unknown function (DUF1847); Region: DUF1847; cl02037
435590005425	DNA repair protein RadA; Provisional; Region: PRK11823
435590005426	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
435590005427	Walker A motif/ATP binding site; other site
435590005428	ATP binding site [chemical binding]; other site
435590005429	Walker B motif; other site
435590005430	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
435590005431	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
435590005432	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
435590005433	putative catalytic residues [active]
435590005434	putative nucleotide binding site [chemical binding]; other site
435590005435	putative aspartate binding site [chemical binding]; other site
435590005436	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
435590005437	dimer interface [polypeptide binding]; other site
435590005438	putative threonine allosteric regulatory site; other site
435590005439	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
435590005440	putative threonine allosteric regulatory site; other site
435590005441	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590005442	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
435590005443	cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200
435590005444	Sulfatase; Region: Sulfatase; cl10460
435590005445	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
435590005446	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560
435590005447	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590005448	catalytic residue [active]
435590005449	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
435590005450	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
435590005451	Walker A/P-loop; other site
435590005452	ATP binding site [chemical binding]; other site
435590005453	Q-loop/lid; other site
435590005454	ABC transporter signature motif; other site
435590005455	Walker B; other site
435590005456	D-loop; other site
435590005457	H-loop/switch region; other site
435590005458	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
435590005459	ABC-ATPase subunit  interface; other site
435590005460	dimer interface [polypeptide binding]; other site
435590005461	putative PBP binding regions; other site
435590005462	Periplasmic binding protein TroA_d.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141
435590005463	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
435590005464	putative ligand binding site [chemical binding]; other site
435590005465	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
435590005466	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
435590005467	N-terminal plug; other site
435590005468	ligand-binding site [chemical binding]; other site
435590005469	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
435590005470	Transposase domain (DUF772); Region: DUF772; cl15789
435590005471	Transposase domain (DUF772); Region: DUF772; cl15789
435590005472	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
435590005473	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590005474	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590005475	NeuB family; Region: NeuB; cl00496
435590005476	Chorismate mutase type II; Region: CM_2; cl00693
435590005477	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
435590005478	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
435590005479	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590005480	homodimer interface [polypeptide binding]; other site
435590005481	catalytic residue [active]
435590005482	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
435590005483	Prephenate dehydratase; Region: PDT; pfam00800
435590005484	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
435590005485	putative L-Phe binding site [chemical binding]; other site
435590005486	Helix-turn-helix domains; Region: HTH; cl00088
435590005487	intracellular protease, PfpI family; Region: PfpI; TIGR01382
435590005488	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
435590005489	conserved cys residue [active]
435590005490	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
435590005491	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
435590005492	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590005493	homodimer interface [polypeptide binding]; other site
435590005494	catalytic residue [active]
435590005495	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
435590005496	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590005497	binding surface
435590005498	TPR motif; other site
435590005499	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590005500	binding surface
435590005501	TPR motif; other site
435590005502	TPR repeat; Region: TPR_11; pfam13414
435590005503	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590005504	binding surface
435590005505	TPR motif; other site
435590005506	TPR repeat; Region: TPR_11; pfam13414
435590005507	TPR repeat; Region: TPR_11; pfam13414
435590005508	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590005509	binding surface
435590005510	TPR motif; other site
435590005511	N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525
435590005512	beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555
435590005513	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590005514	ATP binding site [chemical binding]; other site
435590005515	putative Mg++ binding site [ion binding]; other site
435590005516	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590005517	nucleotide binding region [chemical binding]; other site
435590005518	ATP-binding site [chemical binding]; other site
435590005519	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
435590005520	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
435590005521	DHH family; Region: DHH; pfam01368
435590005522	DHHA1 domain; Region: DHHA1; pfam02272
435590005523	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298
435590005524	active site
435590005525	Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433
435590005526	proline aminopeptidase P II; Provisional; Region: PRK10879
435590005527	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
435590005528	active site
435590005529	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
435590005530	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
435590005531	active site
435590005532	nucleophile elbow; other site
435590005533	phosphodiesterase; Provisional; Region: PRK12704
435590005534	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
435590005535	Cell division protein ZapA; Region: ZapA; cl01146
435590005536	Protein of unknown function (DUF454); Region: DUF454; cl01063
435590005537	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
435590005538	active site
435590005539	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
435590005540	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590005541	FeS/SAM binding site; other site
435590005542	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
435590005543	putative active site [active]
435590005544	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
435590005545	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
435590005546	Divergent AAA domain; Region: AAA_4; pfam04326
435590005547	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590005548	Two component regulator propeller; Region: Reg_prop; pfam07494
435590005549	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590005550	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590005551	dimer interface [polypeptide binding]; other site
435590005552	phosphorylation site [posttranslational modification]
435590005553	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590005554	ATP binding site [chemical binding]; other site
435590005555	Mg2+ binding site [ion binding]; other site
435590005556	G-X-G motif; other site
435590005557	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590005558	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590005559	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
435590005560	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
435590005561	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
435590005562	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
435590005563	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
435590005564	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
435590005565	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
435590005566	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590005567	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
435590005568	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590005569	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590005570	Protein of unknown function (DUF3946); Region: DUF3946; pfam13102
435590005571	Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185
435590005572	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
435590005573	Int/Topo IB signature motif; other site
435590005574	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
435590005575	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
435590005576	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
435590005577	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590005578	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590005579	G1 box; other site
435590005580	GTP/Mg2+ binding site [chemical binding]; other site
435590005581	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
435590005582	putative active site [active]
435590005583	putative metal binding site [ion binding]; other site
435590005584	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
435590005585	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590005586	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590005587	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590005588	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
435590005589	Domain of unknown function (DUF1896); Region: DUF1896; pfam08989
435590005590	Protein of unknown function (DUF4099); Region: DUF4099; pfam13351
435590005591	Protein of unknown function (DUF3945); Region: DUF3945; pfam13101
435590005592	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590005593	FRG domain; Region: FRG; cl07460
435590005594	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590005595	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
435590005596	Walker A motif; other site
435590005597	ATP binding site [chemical binding]; other site
435590005598	Walker B motif; other site
435590005599	TSC-22/dip/bun family; Region: TSC22; cl01853
435590005600	YWFCY protein; Region: YWFCY; pfam14293
435590005601	YWFCY protein; Region: YWFCY; pfam14293
435590005602	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
435590005603	Protein of unknown function (DUF3408); Region: DUF3408; pfam11888
435590005604	Domain of unknown function (DUF4134); Region: DUF4134; pfam13572
435590005605	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
435590005606	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
435590005607	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
435590005608	putative active site [active]
435590005609	putative NTP binding site [chemical binding]; other site
435590005610	putative nucleic acid binding site [nucleotide binding]; other site
435590005611	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
435590005612	Domain of unknown function (DUF4133); Region: DUF4133; pfam13571
435590005613	Bacteroides conjugation system ATPase, TraG family; Region: Bac_Flav_CT_G; TIGR03783
435590005614	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
435590005615	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
435590005616	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
435590005617	putative active site [active]
435590005618	putative NTP binding site [chemical binding]; other site
435590005619	putative nucleic acid binding site [nucleotide binding]; other site
435590005620	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
435590005621	Bacteroides conjugation system ATPase, TraG family; Region: Bac_Flav_CT_G; TIGR03783
435590005622	Domain of unknown function (DUF4141); Region: DUF4141; pfam13605
435590005623	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
435590005624	Bacteroides conjugative transposon TraJ protein; Region: Bac_Flav_CT_J; TIGR03782
435590005625	Bacteroides conjugative transposon TraK protein; Region: Bac_Flav_CT_K; TIGR03781
435590005626	Protein of unknown function (DUF3989); Region: DUF3989; pfam13150
435590005627	Bacteroides conjugative transposon TraM protein; Region: Bac_Flav_CT_M; TIGR03779
435590005628	Protein of unknown function (DUF3714); Region: DUF3714; pfam12508
435590005629	Protein of unknown function (DUF3714); Region: DUF3714; pfam12508
435590005630	Bacteroides conjugative transposon TraN protein; Region: Bac_Flav_CT_N; TIGR03780
435590005631	Domain of unknown function (DUF4138); Region: DUF4138; pfam13595
435590005632	Conjugative transposon protein TraO; Region: TraO; pfam10626
435590005633	Domain of unknown function, B. Theta Gene description (DUF3872); Region: DUF3872; pfam12988
435590005634	Peptidase family M48; Region: Peptidase_M48; cl12018
435590005635	ParB-like nuclease domain; Region: ParBc; cl02129
435590005636	PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734
435590005637	MAEBL; Provisional; Region: PTZ00121
435590005638	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590005639	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590005640	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590005641	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590005642	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590005643	dimer interface [polypeptide binding]; other site
435590005644	phosphorylation site [posttranslational modification]
435590005645	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590005646	ATP binding site [chemical binding]; other site
435590005647	G-X-G motif; other site
435590005648	Response regulator receiver domain; Region: Response_reg; pfam00072
435590005649	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590005650	active site
435590005651	phosphorylation site [posttranslational modification]
435590005652	intermolecular recognition site; other site
435590005653	dimerization interface [polypeptide binding]; other site
435590005654	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590005655	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590005656	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590005657	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590005658	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590005659	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590005660	SusD family; Region: SusD; pfam07980
435590005661	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
435590005662	active site
435590005663	catalytic triad [active]
435590005664	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
435590005665	putative active site [active]
435590005666	putative metal binding site [ion binding]; other site
435590005667	Beta-galactosidase; Region: Glyco_hydro_42; cl03154
435590005668	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
435590005669	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
435590005670	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590005671	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
435590005672	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
435590005673	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
435590005674	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590005675	Two component regulator propeller; Region: Reg_prop; pfam07494
435590005676	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590005677	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590005678	dimer interface [polypeptide binding]; other site
435590005679	phosphorylation site [posttranslational modification]
435590005680	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590005681	ATP binding site [chemical binding]; other site
435590005682	G-X-G motif; other site
435590005683	Response regulator receiver domain; Region: Response_reg; pfam00072
435590005684	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590005685	active site
435590005686	phosphorylation site [posttranslational modification]
435590005687	intermolecular recognition site; other site
435590005688	dimerization interface [polypeptide binding]; other site
435590005689	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590005690	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590005691	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590005692	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590005693	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590005694	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590005695	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590005696	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
435590005697	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
435590005698	active site
435590005699	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
435590005700	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
435590005701	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
435590005702	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
435590005703	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590005704	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
435590005705	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590005706	mannonate dehydratase; Region: uxuA; TIGR00695
435590005707	mannonate dehydratase; Provisional; Region: PRK03906
435590005708	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
435590005709	putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935
435590005710	putative NAD(P) binding site [chemical binding]; other site
435590005711	active site
435590005712	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
435590005713	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590005714	ATP binding site [chemical binding]; other site
435590005715	Mg2+ binding site [ion binding]; other site
435590005716	G-X-G motif; other site
435590005717	Response regulator receiver domain; Region: Response_reg; pfam00072
435590005718	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590005719	active site
435590005720	phosphorylation site [posttranslational modification]
435590005721	intermolecular recognition site; other site
435590005722	dimerization interface [polypeptide binding]; other site
435590005723	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
435590005724	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590005725	active site
435590005726	phosphorylation site [posttranslational modification]
435590005727	intermolecular recognition site; other site
435590005728	dimerization interface [polypeptide binding]; other site
435590005729	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590005730	Walker A motif; other site
435590005731	ATP binding site [chemical binding]; other site
435590005732	Walker B motif; other site
435590005733	arginine finger; other site
435590005734	Helix-turn-helix domains; Region: HTH; cl00088
435590005735	RteC protein; Region: RteC; pfam09357
435590005736	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
435590005737	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
435590005738	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
435590005739	ligand binding site [chemical binding]; other site
435590005740	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590005741	Lipocalin-like domain; Region: Lipocalin_6; pfam13944
435590005742	Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY_like; cd07472
435590005743	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590005744	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
435590005745	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
435590005746	N-terminal plug; other site
435590005747	ligand-binding site [chemical binding]; other site
435590005748	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
435590005749	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
435590005750	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
435590005751	Uncharacterized conserved protein (DUF2149); Region: DUF2149; cl01960
435590005752	Domain of unknown function (DUF4091); Region: DUF4091; pfam13320
435590005753	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
435590005754	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
435590005755	catalytic residues [active]
435590005756	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
435590005757	Susd and RagB outer membrane lipoprotein; Region: SusD-like; pfam12741
435590005758	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590005759	Secretin and TonB N terminus short domain; Region: STN; cl06624
435590005760	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590005761	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590005762	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590005763	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590005764	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590005765	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
435590005766	FecR protein; Region: FecR; pfam04773
435590005767	Phosphoglycerate kinase; Region: PGK; pfam00162
435590005768	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
435590005769	substrate binding site [chemical binding]; other site
435590005770	hinge regions; other site
435590005771	ADP binding site [chemical binding]; other site
435590005772	catalytic site [active]
435590005773	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
435590005774	Cupin domain; Region: Cupin_2; cl09118
435590005775	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
435590005776	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
435590005777	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
435590005778	active site
435590005779	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
435590005780	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
435590005781	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
435590005782	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590005783	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590005784	DNA binding residues [nucleotide binding]
435590005785	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
435590005786	putative efflux protein, MATE family; Region: matE; TIGR00797
435590005787	MatE; Region: MatE; cl10513
435590005788	MatE; Region: MatE; cl10513
435590005789	signal recognition particle protein; Provisional; Region: PRK10867
435590005790	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
435590005791	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
435590005792	P loop; other site
435590005793	GTP binding site [chemical binding]; other site
435590005794	Signal peptide binding domain; Region: SRP_SPB; pfam02978
435590005795	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14185
435590005796	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
435590005797	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
435590005798	homodimer interface [polypeptide binding]; other site
435590005799	NADP binding site [chemical binding]; other site
435590005800	substrate binding site [chemical binding]; other site
435590005801	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
435590005802	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
435590005803	putative active site [active]
435590005804	putative metal binding site [ion binding]; other site
435590005805	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
435590005806	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590005807	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590005808	DNA binding residues [nucleotide binding]
435590005809	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
435590005810	FecR protein; Region: FecR; pfam04773
435590005811	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590005812	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590005813	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590005814	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590005815	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590005816	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
435590005817	catalytic residues [active]
435590005818	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
435590005819	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
435590005820	catalytic residues [active]
435590005821	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
435590005822	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590005823	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
435590005824	Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017
435590005825	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
435590005826	active site
435590005827	catalytic residues [active]
435590005828	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590005829	Two component regulator propeller; Region: Reg_prop; pfam07494
435590005830	Two component regulator propeller; Region: Reg_prop; pfam07494
435590005831	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590005832	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590005833	dimer interface [polypeptide binding]; other site
435590005834	phosphorylation site [posttranslational modification]
435590005835	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590005836	ATP binding site [chemical binding]; other site
435590005837	Mg2+ binding site [ion binding]; other site
435590005838	G-X-G motif; other site
435590005839	Response regulator receiver domain; Region: Response_reg; pfam00072
435590005840	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590005841	active site
435590005842	phosphorylation site [posttranslational modification]
435590005843	intermolecular recognition site; other site
435590005844	dimerization interface [polypeptide binding]; other site
435590005845	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590005846	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590005847	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590005848	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590005849	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590005850	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590005851	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590005852	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590005853	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590005854	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
435590005855	active site
435590005856	Glycosyl hydrolase family 43; Region: GH43_bXyl_2; cd08991
435590005857	active site
435590005858	Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999
435590005859	putative substrate binding site [chemical binding]; other site
435590005860	active site
435590005861	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
435590005862	active site
435590005863	chorismate binding enzyme; Region: Chorismate_bind; cl10555
435590005864	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224
435590005865	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590005866	Major Facilitator Superfamily; Region: MFS_1; pfam07690
435590005867	putative substrate translocation pore; other site
435590005868	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
435590005869	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
435590005870	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
435590005871	dimer interface [polypeptide binding]; other site
435590005872	motif 1; other site
435590005873	active site
435590005874	motif 2; other site
435590005875	motif 3; other site
435590005876	Domain of unknown function (DUF4348); Region: DUF4348; pfam14254
435590005877	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
435590005878	FAD binding domain; Region: FAD_binding_4; pfam01565
435590005879	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
435590005880	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
435590005881	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
435590005882	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
435590005883	minor groove reading motif; other site
435590005884	helix-hairpin-helix signature motif; other site
435590005885	substrate binding pocket [chemical binding]; other site
435590005886	active site
435590005887	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
435590005888	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
435590005889	Amidinotransferase; Region: Amidinotransf; cl12043
435590005890	Amidinotransferase; Region: Amidinotransf; cl12043
435590005891	ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885
435590005892	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
435590005893	inhibitor-cofactor binding pocket; inhibition site
435590005894	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590005895	catalytic residue [active]
435590005896	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756
435590005897	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
435590005898	Ligand Binding Site [chemical binding]; other site
435590005899	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
435590005900	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971
435590005901	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590005902	Walker A motif; other site
435590005903	ATP binding site [chemical binding]; other site
435590005904	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590005905	Walker B motif; other site
435590005906	arginine finger; other site
435590005907	Septum formation initiator; Region: DivIC; cl11433
435590005908	Peptidase S46; Region: Peptidase_S46; pfam10459
435590005909	Peptidase S46; Region: Peptidase_S46; pfam10459
435590005910	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
435590005911	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
435590005912	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
435590005913	putative acyl-acceptor binding pocket; other site
435590005914	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
435590005915	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
435590005916	putative active site [active]
435590005917	putative metal binding site [ion binding]; other site
435590005918	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
435590005919	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
435590005920	dihydroorotase; Reviewed; Region: PRK09236
435590005921	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
435590005922	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
435590005923	active site
435590005924	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
435590005925	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
435590005926	Ligand binding site; other site
435590005927	Putative Catalytic site; other site
435590005928	DXD motif; other site
435590005929	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
435590005930	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
435590005931	NlpE N-terminal domain; Region: NlpE; cl01138
435590005932	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
435590005933	C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561
435590005934	Catalytic dyad [active]
435590005935	aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801
435590005936	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
435590005937	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590005938	homodimer interface [polypeptide binding]; other site
435590005939	catalytic residue [active]
435590005940	aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802
435590005941	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
435590005942	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
435590005943	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
435590005944	Transposase domain (DUF772); Region: DUF772; cl15789
435590005945	Transposase domain (DUF772); Region: DUF772; cl15789
435590005946	TPR repeat; Region: TPR_11; pfam13414
435590005947	TPR repeat; Region: TPR_11; pfam13414
435590005948	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590005949	binding surface
435590005950	TPR motif; other site
435590005951	Tetratricopeptide repeat; Region: TPR_16; pfam13432
435590005952	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590005953	binding surface
435590005954	TPR motif; other site
435590005955	Predicted membrane protein [Function unknown]; Region: COG2311
435590005956	Protein of unknown function (DUF418); Region: DUF418; cl12135
435590005957	Protein of unknown function (DUF418); Region: DUF418; cl12135
435590005958	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
435590005959	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
435590005960	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590005961	ATP binding site [chemical binding]; other site
435590005962	putative Mg++ binding site [ion binding]; other site
435590005963	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590005964	nucleotide binding region [chemical binding]; other site
435590005965	ATP-binding site [chemical binding]; other site
435590005966	TRCF domain; Region: TRCF; cl04088
435590005967	Gram-negative bacterial tonB protein; Region: TonB; cl10048
435590005968	Predicted amidohydrolase [General function prediction only]; Region: COG0388
435590005969	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
435590005970	putative active site [active]
435590005971	catalytic triad [active]
435590005972	multimer interface [polypeptide binding]; other site
435590005973	dimer interface [polypeptide binding]; other site
435590005974	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
435590005975	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
435590005976	dimer interface [polypeptide binding]; other site
435590005977	PYR/PP interface [polypeptide binding]; other site
435590005978	TPP binding site [chemical binding]; other site
435590005979	substrate binding site [chemical binding]; other site
435590005980	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
435590005981	TPP-binding site; other site
435590005982	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
435590005983	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
435590005984	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
435590005985	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590005986	homodimer interface [polypeptide binding]; other site
435590005987	catalytic residue [active]
435590005988	AMP-binding enzyme; Region: AMP-binding; cl15778
435590005989	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
435590005990	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
435590005991	C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882
435590005992	Uncharacterized conserved protein [Function unknown]; Region: COG4715
435590005993	SWIM zinc finger; Region: SWIM; cl15408
435590005994	Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452
435590005995	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
435590005996	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
435590005997	hypothetical protein; Provisional; Region: PRK00955
435590005998	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
435590005999	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
435590006000	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
435590006001	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
435590006002	Interdomain contacts; other site
435590006003	Cytokine receptor motif; other site
435590006004	Right handed beta helix region; Region: Beta_helix; pfam13229
435590006005	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
435590006006	putative acyl-acceptor binding pocket; other site
435590006007	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
435590006008	active site
435590006009	ADP/pyrophosphate binding site [chemical binding]; other site
435590006010	dimerization interface [polypeptide binding]; other site
435590006011	allosteric effector site; other site
435590006012	fructose-1,6-bisphosphate binding site; other site
435590006013	YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524
435590006014	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
435590006015	active site
435590006016	hypothetical protein; Provisional; Region: PRK11770
435590006017	Domain of unknown function (DUF307); Region: DUF307; pfam03733
435590006018	Domain of unknown function (DUF307); Region: DUF307; pfam03733
435590006019	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
435590006020	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590006021	S-adenosylmethionine binding site [chemical binding]; other site
435590006022	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
435590006023	catalytic residues [active]
435590006024	Domain of unknonw function from B. Theta Gene description (DUF3874); Region: DUF3874; pfam12990
435590006025	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
435590006026	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
435590006027	catalytic residues [active]
435590006028	catalytic nucleophile [active]
435590006029	Presynaptic Site I dimer interface [polypeptide binding]; other site
435590006030	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
435590006031	Synaptic Flat tetramer interface [polypeptide binding]; other site
435590006032	Synaptic Site I dimer interface [polypeptide binding]; other site
435590006033	DNA binding site [nucleotide binding]
435590006034	Recombinase; Region: Recombinase; pfam07508
435590006035	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
435590006036	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
435590006037	Radical SAM superfamily; Region: Radical_SAM; pfam04055
435590006038	Domain of unknown function, B. Theta Gene description (DUF3871); Region: DUF3871; pfam12987
435590006039	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590006040	DNA binding site [nucleotide binding]
435590006041	Int/Topo IB signature motif; other site
435590006042	active site
435590006043	VirE N-terminal domain; Region: VirE_N; pfam08800
435590006044	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
435590006045	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
435590006046	Domain of unknown function (DUF4421); Region: DUF4421; pfam14391
435590006047	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
435590006048	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590006049	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
435590006050	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
435590006051	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
435590006052	substrate binding pocket [chemical binding]; other site
435590006053	membrane-bound complex binding site; other site
435590006054	hinge residues; other site
435590006055	Domain of unknown function (DUF4289); Region: DUF4289; pfam14121
435590006056	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
435590006057	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
435590006058	TPP-binding site [chemical binding]; other site
435590006059	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
435590006060	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
435590006061	dimer interface [polypeptide binding]; other site
435590006062	PYR/PP interface [polypeptide binding]; other site
435590006063	TPP binding site [chemical binding]; other site
435590006064	substrate binding site [chemical binding]; other site
435590006065	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
435590006066	Ferredoxin [Energy production and conversion]; Region: COG1146
435590006067	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
435590006068	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
435590006069	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
435590006070	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
435590006071	transketolase; Reviewed; Region: PRK05899
435590006072	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
435590006073	TPP-binding site [chemical binding]; other site
435590006074	dimer interface [polypeptide binding]; other site
435590006075	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
435590006076	PYR/PP interface [polypeptide binding]; other site
435590006077	dimer interface [polypeptide binding]; other site
435590006078	TPP binding site [chemical binding]; other site
435590006079	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
435590006080	L-ribulokinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778
435590006081	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
435590006082	putative N- and C-terminal domain interface [polypeptide binding]; other site
435590006083	putative active site [active]
435590006084	putative MgATP binding site [chemical binding]; other site
435590006085	catalytic site [active]
435590006086	metal binding site [ion binding]; metal-binding site
435590006087	putative carbohydrate binding site [chemical binding]; other site
435590006088	L-arabinose isomerase; Provisional; Region: PRK02929
435590006089	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
435590006090	hexamer (dimer of trimers) interface [polypeptide binding]; other site
435590006091	trimer interface [polypeptide binding]; other site
435590006092	substrate binding site [chemical binding]; other site
435590006093	Mn binding site [ion binding]; other site
435590006094	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
435590006095	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
435590006096	intersubunit interface [polypeptide binding]; other site
435590006097	active site
435590006098	Zn2+ binding site [ion binding]; other site
435590006099	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
435590006100	nudix motif; other site
435590006101	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
435590006102	Sodium:solute symporter family; Region: SSF; cl00456
435590006103	Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017
435590006104	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
435590006105	active site
435590006106	catalytic residues [active]
435590006107	galactokinase; Provisional; Region: PRK05322
435590006108	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
435590006109	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
435590006110	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
435590006111	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
435590006112	Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017
435590006113	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
435590006114	active site
435590006115	catalytic residues [active]
435590006116	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
435590006117	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
435590006118	chaperone protein DnaJ; Provisional; Region: PRK14289
435590006119	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
435590006120	HSP70 interaction site [polypeptide binding]; other site
435590006121	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
435590006122	Zn binding sites [ion binding]; other site
435590006123	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
435590006124	dimer interface [polypeptide binding]; other site
435590006125	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
435590006126	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
435590006127	dimer interface [polypeptide binding]; other site
435590006128	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
435590006129	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
435590006130	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590006131	Walker A/P-loop; other site
435590006132	ATP binding site [chemical binding]; other site
435590006133	Q-loop/lid; other site
435590006134	ABC transporter signature motif; other site
435590006135	Walker B; other site
435590006136	D-loop; other site
435590006137	H-loop/switch region; other site
435590006138	ABC transporter; Region: ABC_tran_2; pfam12848
435590006139	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
435590006140	Domain of unknown function (DUF303); Region: DUF303; pfam03629
435590006141	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
435590006142	active site
435590006143	catalytic triad [active]
435590006144	oxyanion hole [active]
435590006145	Protein of unknown function (DUF1006); Region: DUF1006; cl15826
435590006146	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
435590006147	active site
435590006148	catalytic motif [active]
435590006149	Zn binding site [ion binding]; other site
435590006150	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
435590006151	SmpA / OmlA family; Region: SmpA_OmlA; cl01095
435590006152	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
435590006153	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590006154	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590006155	DNA binding residues [nucleotide binding]
435590006156	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620
435590006157	putative ligand binding site [chemical binding]; other site
435590006158	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
435590006159	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
435590006160	putative peptidoglycan binding site; other site
435590006161	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107
435590006162	bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000
435590006163	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
435590006164	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
435590006165	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590006166	FtsX-like permease family; Region: FtsX; cl15850
435590006167	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
435590006168	FtsX-like permease family; Region: FtsX; cl15850
435590006169	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
435590006170	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
435590006171	Walker A/P-loop; other site
435590006172	ATP binding site [chemical binding]; other site
435590006173	Q-loop/lid; other site
435590006174	ABC transporter signature motif; other site
435590006175	Walker B; other site
435590006176	D-loop; other site
435590006177	H-loop/switch region; other site
435590006178	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590006179	FtsX-like permease family; Region: FtsX; cl15850
435590006180	FtsX-like permease family; Region: FtsX; cl15850
435590006181	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590006182	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
435590006183	FtsX-like permease family; Region: FtsX; cl15850
435590006184	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
435590006185	FtsX-like permease family; Region: FtsX; cl15850
435590006186	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590006187	FtsX-like permease family; Region: FtsX; cl15850
435590006188	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590006189	FtsX-like permease family; Region: FtsX; cl15850
435590006190	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
435590006191	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
435590006192	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590006193	active site
435590006194	phosphorylation site [posttranslational modification]
435590006195	intermolecular recognition site; other site
435590006196	dimerization interface [polypeptide binding]; other site
435590006197	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590006198	Walker A motif; other site
435590006199	ATP binding site [chemical binding]; other site
435590006200	Walker B motif; other site
435590006201	arginine finger; other site
435590006202	Helix-turn-helix domains; Region: HTH; cl00088
435590006203	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
435590006204	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
435590006205	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
435590006206	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590006207	ATP binding site [chemical binding]; other site
435590006208	Mg2+ binding site [ion binding]; other site
435590006209	G-X-G motif; other site
435590006210	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
435590006211	substrate binding pocket [chemical binding]; other site
435590006212	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
435590006213	membrane-bound complex binding site; other site
435590006214	hinge residues; other site
435590006215	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
435590006216	N-acetyl-D-glucosamine binding site [chemical binding]; other site
435590006217	catalytic residue [active]
435590006218	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
435590006219	Sugar specificity; other site
435590006220	Pyrimidine base specificity; other site
435590006221	ATP-binding site [chemical binding]; other site
435590006222	Stress responsive A/B Barrel Domain; Region: Dabb; cl15807
435590006223	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
435590006224	CoenzymeA binding site [chemical binding]; other site
435590006225	subunit interaction site [polypeptide binding]; other site
435590006226	PHB binding site; other site
435590006227	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
435590006228	ATP phosphoribosyltransferase; Region: HisG; cl15266
435590006229	HisG, C-terminal domain; Region: HisG_C; cl06867
435590006230	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
435590006231	histidinol dehydrogenase; Region: hisD; TIGR00069
435590006232	NAD binding site [chemical binding]; other site
435590006233	dimerization interface [polypeptide binding]; other site
435590006234	product binding site; other site
435590006235	substrate binding site [chemical binding]; other site
435590006236	zinc binding site [ion binding]; other site
435590006237	catalytic residues [active]
435590006238	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
435590006239	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
435590006240	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590006241	homodimer interface [polypeptide binding]; other site
435590006242	catalytic residue [active]
435590006243	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
435590006244	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
435590006245	active site
435590006246	motif I; other site
435590006247	motif II; other site
435590006248	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
435590006249	putative active site pocket [active]
435590006250	4-fold oligomerization interface [polypeptide binding]; other site
435590006251	metal binding residues [ion binding]; metal-binding site
435590006252	3-fold/trimer interface [polypeptide binding]; other site
435590006253	NAD synthetase; Reviewed; Region: nadE; PRK02628
435590006254	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
435590006255	multimer interface [polypeptide binding]; other site
435590006256	active site
435590006257	catalytic triad [active]
435590006258	protein interface 1 [polypeptide binding]; other site
435590006259	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
435590006260	homodimer interface [polypeptide binding]; other site
435590006261	NAD binding pocket [chemical binding]; other site
435590006262	ATP binding pocket [chemical binding]; other site
435590006263	Mg binding site [ion binding]; other site
435590006264	active-site loop [active]
435590006265	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
435590006266	metal binding site 2 [ion binding]; metal-binding site
435590006267	putative DNA binding helix; other site
435590006268	metal binding site 1 [ion binding]; metal-binding site
435590006269	dimer interface [polypeptide binding]; other site
435590006270	structural Zn2+ binding site [ion binding]; other site
435590006271	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
435590006272	Rubredoxin; Region: Rubredoxin; pfam00301
435590006273	iron binding site [ion binding]; other site
435590006274	rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046
435590006275	diiron binding motif [ion binding]; other site
435590006276	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
435590006277	catalytic residues [active]
435590006278	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
435590006279	catalytic residues [active]
435590006280	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
435590006281	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
435590006282	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
435590006283	metal binding site [ion binding]; metal-binding site
435590006284	dimer interface [polypeptide binding]; other site
435590006285	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
435590006286	putative catalytic site [active]
435590006287	putative metal binding site [ion binding]; other site
435590006288	putative phosphate binding site [ion binding]; other site
435590006289	Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679
435590006290	Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590
435590006291	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
435590006292	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
435590006293	dimerization interface [polypeptide binding]; other site
435590006294	active site
435590006295	recombinase A; Provisional; Region: recA; PRK09354
435590006296	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
435590006297	hexamer interface [polypeptide binding]; other site
435590006298	Walker A motif; other site
435590006299	ATP binding site [chemical binding]; other site
435590006300	Walker B motif; other site
435590006301	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
435590006302	catalytic triad [active]
435590006303	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
435590006304	META domain; Region: META; cl01245
435590006305	META domain; Region: META; cl01245
435590006306	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
435590006307	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
435590006308	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
435590006309	Divergent AAA domain; Region: AAA_4; pfam04326
435590006310	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
435590006311	Helix-turn-helix domains; Region: HTH; cl00088
435590006312	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590006313	DNA binding site [nucleotide binding]
435590006314	Int/Topo IB signature motif; other site
435590006315	active site
435590006316	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
435590006317	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
435590006318	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
435590006319	motif I; other site
435590006320	active site
435590006321	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
435590006322	SLBB domain; Region: SLBB; pfam10531
435590006323	tyrosine kinase; Provisional; Region: PRK11519
435590006324	Chain length determinant protein; Region: Wzz; cl15801
435590006325	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
435590006326	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
435590006327	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
435590006328	P loop; other site
435590006329	Nucleotide binding site [chemical binding]; other site
435590006330	DTAP/Switch II; other site
435590006331	Switch I; other site
435590006332	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
435590006333	Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035
435590006334	4Fe-4S binding domain; Region: Fer4; cl02805
435590006335	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
435590006336	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
435590006337	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
435590006338	active site
435590006339	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590006340	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
435590006341	putative ADP-binding pocket [chemical binding]; other site
435590006342	4Fe-4S binding domain; Region: Fer4; cl02805
435590006343	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
435590006344	4Fe-4S binding domain; Region: Fer4; cl02805
435590006345	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
435590006346	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
435590006347	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
435590006348	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590006349	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
435590006350	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590006351	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
435590006352	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
435590006353	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
435590006354	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
435590006355	substrate binding site; other site
435590006356	tetramer interface; other site
435590006357	Cupin domain; Region: Cupin_2; cl09118
435590006358	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
435590006359	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
435590006360	NADP binding site [chemical binding]; other site
435590006361	active site
435590006362	putative substrate binding site [chemical binding]; other site
435590006363	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
435590006364	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
435590006365	NAD binding site [chemical binding]; other site
435590006366	substrate binding site [chemical binding]; other site
435590006367	homodimer interface [polypeptide binding]; other site
435590006368	active site
435590006369	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590006370	Bacterial sugar transferase; Region: Bac_transf; cl00939
435590006371	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
435590006372	amidase catalytic site [active]
435590006373	Zn binding residues [ion binding]; other site
435590006374	substrate binding site [chemical binding]; other site
435590006375	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
435590006376	Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707
435590006377	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
435590006378	VirE N-terminal domain; Region: VirE_N; pfam08800
435590006379	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590006380	ATP binding site [chemical binding]; other site
435590006381	putative Mg++ binding site [ion binding]; other site
435590006382	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590006383	nucleotide binding region [chemical binding]; other site
435590006384	ATP-binding site [chemical binding]; other site
435590006385	Domain of unknown function (DUF4250); Region: DUF4250; pfam14056
435590006386	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590006387	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824
435590006388	AMP-binding enzyme; Region: AMP-binding; cl15778
435590006389	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
435590006390	o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927
435590006391	active site
435590006392	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
435590006393	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
435590006394	substrate binding site [chemical binding]; other site
435590006395	oxyanion hole (OAH) forming residues; other site
435590006396	trimer interface [polypeptide binding]; other site
435590006397	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173
435590006398	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
435590006399	dimer interface [polypeptide binding]; other site
435590006400	tetramer interface [polypeptide binding]; other site
435590006401	PYR/PP interface [polypeptide binding]; other site
435590006402	TPP binding site [chemical binding]; other site
435590006403	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
435590006404	TPP-binding site; other site
435590006405	aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824
435590006406	chorismate binding enzyme; Region: Chorismate_bind; cl10555
435590006407	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
435590006408	CoenzymeA binding site [chemical binding]; other site
435590006409	subunit interaction site [polypeptide binding]; other site
435590006410	PHB binding site; other site
435590006411	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
435590006412	MatE; Region: MatE; cl10513
435590006413	MatE; Region: MatE; cl10513
435590006414	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
435590006415	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
435590006416	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
435590006417	Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524
435590006418	active site residue [active]
435590006419	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436
435590006420	CPxP  motif; other site
435590006421	DsrE/DsrF-like family; Region: DrsE; cl00672
435590006422	Helix-turn-helix domains; Region: HTH; cl00088
435590006423	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
435590006424	Voltage gated chloride channel; Region: Voltage_CLC; pfam00654
435590006425	Cl- selectivity filter; other site
435590006426	Cl- binding residues [ion binding]; other site
435590006427	pore gating glutamate residue; other site
435590006428	dimer interface [polypeptide binding]; other site
435590006429	H+/Cl- coupling transport residue; other site
435590006430	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
435590006431	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
435590006432	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590006433	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590006434	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590006435	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590006436	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590006437	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590006438	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590006439	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590006440	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
435590006441	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
435590006442	catalytic residues [active]
435590006443	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590006444	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590006445	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590006446	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590006447	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590006448	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
435590006449	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590006450	endonuclease IV; Provisional; Region: PRK01060
435590006451	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
435590006452	AP (apurinic/apyrimidinic) site pocket; other site
435590006453	DNA interaction; other site
435590006454	Metal-binding active site; metal-binding site
435590006455	type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897
435590006456	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
435590006457	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
435590006458	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
435590006459	catalytic residue [active]
435590006460	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
435590006461	Cation transport protein; Region: TrkH; cl10514
435590006462	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
435590006463	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590006464	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
435590006465	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
435590006466	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
435590006467	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
435590006468	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
435590006469	Shewanella-like phosphatases, metallophosphatase domain; Region: MPP_Shelphs; cd07425
435590006470	active site
435590006471	metal binding site [ion binding]; metal-binding site
435590006472	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590006473	Secretin and TonB N terminus short domain; Region: STN; cl06624
435590006474	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590006475	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590006476	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590006477	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590006478	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590006479	FecR protein; Region: FecR; pfam04773
435590006480	Helix-turn-helix domains; Region: HTH; cl00088
435590006481	DNA binding residues [nucleotide binding]
435590006482	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
435590006483	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590006484	Walker A/P-loop; other site
435590006485	ATP binding site [chemical binding]; other site
435590006486	Q-loop/lid; other site
435590006487	ABC transporter signature motif; other site
435590006488	Walker B; other site
435590006489	D-loop; other site
435590006490	H-loop/switch region; other site
435590006491	Plant ATP synthase F0; Region: YMF19; cl07975
435590006492	Smr domain; Region: Smr; cl02619
435590006493	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
435590006494	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
435590006495	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
435590006496	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
435590006497	Axonemal dynein light chain; Region: Ax_dynein_light; pfam10211
435590006498	CHC2 zinc finger; Region: zf-CHC2; cl15369
435590006499	DNA primase, catalytic core; Region: dnaG; TIGR01391
435590006500	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
435590006501	AAA domain; Region: AAA_25; pfam13481
435590006502	Protein of unknown function (DUF3853); Region: DUF3853; pfam12964
435590006503	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590006504	DNA binding site [nucleotide binding]
435590006505	Int/Topo IB signature motif; other site
435590006506	active site
435590006507	Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185
435590006508	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
435590006509	Int/Topo IB signature motif; other site
435590006510	ORF6N domain; Region: ORF6N; pfam10543
435590006511	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
435590006512	MPN+ (JAMM) motif; other site
435590006513	Zinc-binding site [ion binding]; other site
435590006514	Antirestriction protein (ArdA); Region: ArdA; cl01953
435590006515	Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950
435590006516	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590006517	Walker A/P-loop; other site
435590006518	ATP binding site [chemical binding]; other site
435590006519	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
435590006520	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
435590006521	active site
435590006522	metal binding site [ion binding]; metal-binding site
435590006523	interdomain interaction site; other site
435590006524	AAA domain; Region: AAA_25; pfam13481
435590006525	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
435590006526	Bacterial PH domain; Region: DUF304; cl01348
435590006527	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
435590006528	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
435590006529	ligand binding site [chemical binding]; other site
435590006530	flexible hinge region; other site
435590006531	OpgC protein; Region: OpgC_C; cl00792
435590006532	Acyltransferase family; Region: Acyl_transf_3; pfam01757
435590006533	Helix-turn-helix domains; Region: HTH; cl00088
435590006534	metal binding site 2 [ion binding]; metal-binding site
435590006535	putative DNA binding helix; other site
435590006536	metal binding site 1 [ion binding]; metal-binding site
435590006537	dimer interface [polypeptide binding]; other site
435590006538	structural Zn2+ binding site [ion binding]; other site
435590006539	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
435590006540	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
435590006541	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
435590006542	Predicted esterase [General function prediction only]; Region: COG0627
435590006543	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
435590006544	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
435590006545	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
435590006546	putative NAD(P) binding site [chemical binding]; other site
435590006547	homodimer interface [polypeptide binding]; other site
435590006548	homotetramer interface [polypeptide binding]; other site
435590006549	active site
435590006550	Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438
435590006551	Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816
435590006552	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
435590006553	carboxyltransferase (CT) interaction site; other site
435590006554	biotinylation site [posttranslational modification]; other site
435590006555	Lamin Tail Domain; Region: LTD; pfam00932
435590006556	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
435590006557	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
435590006558	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
435590006559	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
435590006560	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
435590006561	dimer interface [polypeptide binding]; other site
435590006562	substrate binding site [chemical binding]; other site
435590006563	metal binding site [ion binding]; metal-binding site
435590006564	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
435590006565	NAD(P)H:flavin oxidoreductase-like family 2.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_2; cd02151
435590006566	putative FMN binding site [chemical binding]; other site
435590006567	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
435590006568	Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778
435590006569	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
435590006570	Maf-like protein; Region: Maf; pfam02545
435590006571	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
435590006572	active site
435590006573	dimer interface [polypeptide binding]; other site
435590006574	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
435590006575	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590006576	Protein of unknown function (DUF3843); Region: DUF3843; pfam12954
435590006577	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
435590006578	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
435590006579	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590006580	putative substrate translocation pore; other site
435590006581	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
435590006582	catalytic residues [active]
435590006583	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590006584	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590006585	PepSY-associated TM helix; Region: PepSY_TM_2; cl15813
435590006586	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
435590006587	Protein of unknown function (DUF1699); Region: DUF1699; pfam08004
435590006588	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
435590006589	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
435590006590	Walker A/P-loop; other site
435590006591	ATP binding site [chemical binding]; other site
435590006592	Q-loop/lid; other site
435590006593	ABC transporter signature motif; other site
435590006594	Walker B; other site
435590006595	D-loop; other site
435590006596	H-loop/switch region; other site
435590006597	GGGtGRT protein; Region: GGGtGRT; pfam14057
435590006598	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
435590006599	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528
435590006600	Domain of unknown function (DUF4375); Region: DUF4375; pfam14300
435590006601	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
435590006602	NigD-like protein; Region: NigD; pfam12667
435590006603	Protein of unknown function (DUF3988); Region: DUF3988; pfam13149
435590006604	Protein of unknown function (DUF3988); Region: DUF3988; pfam13149
435590006605	Protein of unknown function (DUF3988); Region: DUF3988; pfam13149
435590006606	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590006607	DNA binding site [nucleotide binding]
435590006608	Int/Topo IB signature motif; other site
435590006609	active site
435590006610	Yip1 domain; Region: Yip1; cl12048
435590006611	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
435590006612	SmpB-tmRNA interface; other site
435590006613	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
435590006614	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
435590006615	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
435590006616	substrate binding pocket [chemical binding]; other site
435590006617	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
435590006618	B12 binding site [chemical binding]; other site
435590006619	cobalt ligand [ion binding]; other site
435590006620	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
435590006621	Substrate binding site; other site
435590006622	metal-binding site
435590006623	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
435590006624	Phosphotransferase enzyme family; Region: APH; pfam01636
435590006625	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
435590006626	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
435590006627	xanthine permease; Region: pbuX; TIGR03173
435590006628	Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503
435590006629	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
435590006630	active site
435590006631	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863
435590006632	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
435590006633	putative FMN binding site [chemical binding]; other site
435590006634	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
435590006635	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
435590006636	metal binding site [ion binding]; metal-binding site
435590006637	putative dimer interface [polypeptide binding]; other site
435590006638	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
435590006639	Tetramer interface [polypeptide binding]; other site
435590006640	active site
435590006641	FMN-binding site [chemical binding]; other site
435590006642	LemA family; Region: LemA; cl00742
435590006643	Repair protein; Region: Repair_PSII; cl01535
435590006644	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
435590006645	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
435590006646	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
435590006647	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
435590006648	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
435590006649	shikimate binding site; other site
435590006650	NAD(P) binding site [chemical binding]; other site
435590006651	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
435590006652	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590006653	S-adenosylmethionine binding site [chemical binding]; other site
435590006654	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
435590006655	ATP binding site [chemical binding]; other site
435590006656	active site
435590006657	substrate binding site [chemical binding]; other site
435590006658	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
435590006659	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590006660	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
435590006661	PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570
435590006662	dimerization interface 3.5A [polypeptide binding]; other site
435590006663	active site
435590006664	Domain of unknown function (DUF4130; Region: DUF4130; cl14836
435590006665	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
435590006666	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
435590006667	FeS/SAM binding site; other site
435590006668	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
435590006669	catalytic residues [active]
435590006670	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590006671	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590006672	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590006673	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590006674	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590006675	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590006676	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
435590006677	Dehydratase family; Region: ILVD_EDD; cl00340
435590006678	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
435590006679	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
435590006680	PYR/PP interface [polypeptide binding]; other site
435590006681	dimer interface [polypeptide binding]; other site
435590006682	TPP binding site [chemical binding]; other site
435590006683	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
435590006684	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
435590006685	TPP-binding site [chemical binding]; other site
435590006686	dimer interface [polypeptide binding]; other site
435590006687	Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440
435590006688	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
435590006689	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
435590006690	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
435590006691	active site
435590006692	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
435590006693	active site 2 [active]
435590006694	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590006695	ketol-acid reductoisomerase; Region: ilvC; TIGR00465
435590006696	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
435590006697	Gram-negative bacterial tonB protein; Region: TonB; cl10048
435590006698	Gram-negative bacterial tonB protein; Region: TonB; cl10048
435590006699	Gram-negative bacterial tonB protein; Region: TonB; cl10048
435590006700	SurA N-terminal domain; Region: SurA_N_3; cl07813
435590006701	periplasmic folding chaperone; Provisional; Region: PRK10788
435590006702	PPIC-type PPIASE domain; Region: Rotamase; cl08278
435590006703	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
435590006704	Domain of unknown function DUF21; Region: DUF21; pfam01595
435590006705	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
435590006706	Transporter associated domain; Region: CorC_HlyC; cl08393
435590006707	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
435590006708	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590006709	binding surface
435590006710	TPR motif; other site
435590006711	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
435590006712	Type III pantothenate kinase; Region: Pan_kinase; cl09130
435590006713	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
435590006714	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
435590006715	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901
435590006716	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
435590006717	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590006718	nucleotide binding region [chemical binding]; other site
435590006719	ATP-binding site [chemical binding]; other site
435590006720	SEC-C motif; Region: SEC-C; pfam02810
435590006721	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
435590006722	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590006723	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590006724	DNA binding residues [nucleotide binding]
435590006725	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
435590006726	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
435590006727	active site
435590006728	HIGH motif; other site
435590006729	nucleotide binding site [chemical binding]; other site
435590006730	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
435590006731	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
435590006732	active site
435590006733	KMSKS motif; other site
435590006734	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
435590006735	tRNA binding surface [nucleotide binding]; other site
435590006736	anticodon binding site; other site
435590006737	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
435590006738	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
435590006739	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
435590006740	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
435590006741	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590006742	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590006743	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590006744	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590006745	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
435590006746	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590006747	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590006748	DNA binding residues [nucleotide binding]
435590006749	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
435590006750	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
435590006751	DNA-binding site [nucleotide binding]; DNA binding site
435590006752	RNA-binding motif; other site
435590006753	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
435590006754	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
435590006755	RNA binding site [nucleotide binding]; other site
435590006756	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
435590006757	RNA binding site [nucleotide binding]; other site
435590006758	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688
435590006759	RNA binding site [nucleotide binding]; other site
435590006760	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
435590006761	RNA binding site [nucleotide binding]; other site
435590006762	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
435590006763	RNA binding site [nucleotide binding]; other site
435590006764	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
435590006765	Protein of unknown function (DUF541); Region: SIMPL; cl01077
435590006766	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
435590006767	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
435590006768	putative active site [active]
435590006769	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
435590006770	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
435590006771	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
435590006772	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590006773	active site
435590006774	phosphorylation site [posttranslational modification]
435590006775	intermolecular recognition site; other site
435590006776	dimerization interface [polypeptide binding]; other site
435590006777	LytTr DNA-binding domain; Region: LytTR; cl04498
435590006778	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
435590006779	Histidine kinase; Region: His_kinase; pfam06580
435590006780	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
435590006781	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
435590006782	Domain of unknown function (DUF4251); Region: DUF4251; pfam14059
435590006783	Domain of unknown function (DUF4251); Region: DUF4251; pfam14059
435590006784	muropeptide transporter; Validated; Region: ampG; PRK11010
435590006785	AmpG-related permease; Region: 2A0125; TIGR00901
435590006786	Stage II sporulation protein; Region: SpoIID; pfam08486
435590006787	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
435590006788	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
435590006789	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
435590006790	active site
435590006791	ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360
435590006792	ATP adenylyltransferase; Region: ATP_transf; pfam09830
435590006793	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14466
435590006794	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
435590006795	FeS/SAM binding site; other site
435590006796	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
435590006797	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
435590006798	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
435590006799	active site
435590006800	alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768
435590006801	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
435590006802	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
435590006803	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
435590006804	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
435590006805	motif II; other site
435590006806	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
435590006807	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590006808	putative substrate translocation pore; other site
435590006809	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
435590006810	Ribokinase-like subgroup D.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_D; cd01937
435590006811	substrate binding site [chemical binding]; other site
435590006812	ATP binding site [chemical binding]; other site
435590006813	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
435590006814	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590006815	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
435590006816	Walker A motif; other site
435590006817	ATP binding site [chemical binding]; other site
435590006818	Walker B motif; other site
435590006819	arginine finger; other site
435590006820	transcriptional regulator PpsR; Region: PpsR-CrtJ; TIGR02040
435590006821	Helix-turn-helix domains; Region: HTH; cl00088
435590006822	Lipopolysaccharide-assembly; Region: LptE; cl01125
435590006823	Preprotein translocase SecG subunit; Region: SecG; cl09123
435590006824	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
435590006825	active site
435590006826	DNA binding site [nucleotide binding]
435590006827	putative phosphate binding site [ion binding]; other site
435590006828	putative catalytic site [active]
435590006829	metal binding site A [ion binding]; metal-binding site
435590006830	AP binding site [nucleotide binding]; other site
435590006831	metal binding site B [ion binding]; metal-binding site
435590006832	Pirin-related protein [General function prediction only]; Region: COG1741
435590006833	Cupin domain; Region: Cupin_2; cl09118
435590006834	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
435590006835	homopentamer interface [polypeptide binding]; other site
435590006836	active site
435590006837	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
435590006838	TPR motif; other site
435590006839	binding surface
435590006840	recombination protein F; Reviewed; Region: recF; PRK00064
435590006841	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590006842	Walker A/P-loop; other site
435590006843	ATP binding site [chemical binding]; other site
435590006844	Q-loop/lid; other site
435590006845	ABC transporter signature motif; other site
435590006846	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590006847	ABC transporter signature motif; other site
435590006848	Walker B; other site
435590006849	D-loop; other site
435590006850	H-loop/switch region; other site
435590006851	Protein of unknown function (DUF721); Region: DUF721; cl02324
435590006852	Transposase domain (DUF772); Region: DUF772; cl15789
435590006853	Transposase domain (DUF772); Region: DUF772; cl15789
435590006854	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360
435590006855	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
435590006856	C-terminal peptidase (prc); Region: prc; TIGR00225
435590006857	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
435590006858	protein binding site [polypeptide binding]; other site
435590006859	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
435590006860	Catalytic dyad [active]
435590006861	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
435590006862	catalytic motif [active]
435590006863	Zn binding site [ion binding]; other site
435590006864	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
435590006865	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
435590006866	active site
435590006867	Zn binding site [ion binding]; other site
435590006868	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
435590006869	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
435590006870	ligand binding site [chemical binding]; other site
435590006871	flexible hinge region; other site
435590006872	Helix-turn-helix domains; Region: HTH; cl00088
435590006873	MarC family integral membrane protein; Region: MarC; cl00919
435590006874	ApbE family; Region: ApbE; cl00643
435590006875	Domain of unknown function DUF; Region: DUF204; pfam02659
435590006876	Domain of unknown function DUF; Region: DUF204; pfam02659
435590006877	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
435590006878	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
435590006879	Ligand binding site; other site
435590006880	Putative Catalytic site; other site
435590006881	DXD motif; other site
435590006882	Protein of unknown function (DUF4199); Region: DUF4199; pfam13858
435590006883	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590006884	ATP binding site [chemical binding]; other site
435590006885	putative Mg++ binding site [ion binding]; other site
435590006886	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590006887	nucleotide binding region [chemical binding]; other site
435590006888	ATP-binding site [chemical binding]; other site
435590006889	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
435590006890	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
435590006891	enolase; Provisional; Region: eno; PRK00077
435590006892	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
435590006893	dimer interface [polypeptide binding]; other site
435590006894	metal binding site [ion binding]; metal-binding site
435590006895	substrate binding pocket [chemical binding]; other site
435590006896	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
435590006897	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
435590006898	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
435590006899	Putative collagen-binding domain of a collagenase; Region: Collagen_bind_2; pfam12904
435590006900	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
435590006901	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801
435590006902	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl01922
435590006903	BNR repeat-like domain; Region: BNR_2; pfam13088
435590006904	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
435590006905	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
435590006906	Right handed beta helix region; Region: Beta_helix; pfam13229
435590006907	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801
435590006908	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
435590006909	active site
435590006910	motif I; other site
435590006911	motif II; other site
435590006912	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
435590006913	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
435590006914	Substrate binding site; other site
435590006915	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
435590006916	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
435590006917	NADP binding site [chemical binding]; other site
435590006918	active site
435590006919	putative substrate binding site [chemical binding]; other site
435590006920	GDP-mannose 4,6-dehydratase; Region: gmd; TIGR01472
435590006921	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
435590006922	NADP-binding site; other site
435590006923	homotetramer interface [polypeptide binding]; other site
435590006924	substrate binding site [chemical binding]; other site
435590006925	homodimer interface [polypeptide binding]; other site
435590006926	active site
435590006927	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
435590006928	metal-binding site
435590006929	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
435590006930	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
435590006931	putative metal binding site; other site
435590006932	Acyltransferase family; Region: Acyl_transf_3; pfam01757
435590006933	putative acyl transferase; Provisional; Region: PRK10502
435590006934	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
435590006935	putative trimer interface [polypeptide binding]; other site
435590006936	putative active site [active]
435590006937	putative substrate binding site [chemical binding]; other site
435590006938	putative CoA binding site [chemical binding]; other site
435590006939	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590006940	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
435590006941	putative ADP-binding pocket [chemical binding]; other site
435590006942	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
435590006943	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
435590006944	substrate binding site [chemical binding]; other site
435590006945	ATP binding site [chemical binding]; other site
435590006946	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
435590006947	4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944
435590006948	active site
435590006949	catalytic residues [active]
435590006950	metal binding site [ion binding]; metal-binding site
435590006951	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
435590006952	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641
435590006953	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
435590006954	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590006955	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
435590006956	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
435590006957	putative trimer interface [polypeptide binding]; other site
435590006958	putative CoA binding site [chemical binding]; other site
435590006959	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
435590006960	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
435590006961	active site
435590006962	NTP binding site [chemical binding]; other site
435590006963	metal binding triad [ion binding]; metal-binding site
435590006964	antibiotic binding site [chemical binding]; other site
435590006965	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
435590006966	transcriptional activator RfaH; Region: RfaH; TIGR01955
435590006967	KOW motif; Region: KOW; cl00354
435590006968	VirE N-terminal domain; Region: VirE_N; pfam08800
435590006969	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
435590006970	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
435590006971	IHF dimer interface [polypeptide binding]; other site
435590006972	IHF - DNA interface [nucleotide binding]; other site
435590006973	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
435590006974	amidase catalytic site [active]
435590006975	Zn binding residues [ion binding]; other site
435590006976	substrate binding site [chemical binding]; other site
435590006977	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
435590006978	Chain length determinant protein; Region: Wzz; cl15801
435590006979	Chain length determinant protein; Region: Wzz; cl15801
435590006980	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
435590006981	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590006982	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
435590006983	SLBB domain; Region: SLBB; pfam10531
435590006984	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
435590006985	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590006986	Bacterial sugar transferase; Region: Bac_transf; cl00939
435590006987	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590006988	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
435590006989	DNA binding site [nucleotide binding]
435590006990	Int/Topo IB signature motif; other site
435590006991	active site
435590006992	Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842
435590006993	Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842
435590006994	Domain of unknown function, B. Theta Gene description (DUF3868); Region: DUF3868; pfam12984
435590006995	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
435590006996	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
435590006997	Protein of unknown function (DUF3575); Region: DUF3575; pfam12099
435590006998	Domain of unknown function, B. Theta Gene description (DUF3868); Region: DUF3868; pfam12984
435590006999	Protein of unknown function (DUF3575); Region: DUF3575; pfam12099
435590007000	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590007001	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
435590007002	DNA binding site [nucleotide binding]
435590007003	Int/Topo IB signature motif; other site
435590007004	active site
435590007005	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
435590007006	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
435590007007	active site
435590007008	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
435590007009	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590007010	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
435590007011	Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721
435590007012	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
435590007013	putative transporter; Validated; Region: PRK03818
435590007014	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
435590007015	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
435590007016	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
435590007017	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
435590007018	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590007019	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590007020	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590007021	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590007022	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590007023	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590007024	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590007025	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590007026	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590007027	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590007028	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590007029	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
435590007030	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
435590007031	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590007032	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
435590007033	Beta galactosidase small chain; Region: Bgal_small_N; cl03787
435590007034	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
435590007035	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590007036	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
435590007037	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
435590007038	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
435590007039	Domain of unknown function (DUF303); Region: DUF303; pfam03629
435590007040	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
435590007041	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
435590007042	active site
435590007043	magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383
435590007044	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
435590007045	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
435590007046	Helix-turn-helix domains; Region: HTH; cl00088
435590007047	Helix-turn-helix domains; Region: HTH; cl00088
435590007048	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
435590007049	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
435590007050	Phosphate transporter family; Region: PHO4; cl00396
435590007051	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
435590007052	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
435590007053	N-terminal plug; other site
435590007054	ligand-binding site [chemical binding]; other site
435590007055	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
435590007056	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
435590007057	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
435590007058	homodimer interface [polypeptide binding]; other site
435590007059	substrate-cofactor binding pocket; other site
435590007060	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590007061	catalytic residue [active]
435590007062	L-lactate permease; Region: Lactate_perm; cl00701
435590007063	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590007064	two-component sensor protein; Provisional; Region: cpxA; PRK09470
435590007065	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590007066	ATP binding site [chemical binding]; other site
435590007067	Mg2+ binding site [ion binding]; other site
435590007068	G-X-G motif; other site
435590007069	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590007070	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590007071	active site
435590007072	phosphorylation site [posttranslational modification]
435590007073	intermolecular recognition site; other site
435590007074	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
435590007075	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
435590007076	Mechanosensitive ion channel; Region: MS_channel; pfam00924
435590007077	AMP-binding domain protein; Validated; Region: PRK08315
435590007078	AMP-binding enzyme; Region: AMP-binding; cl15778
435590007079	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
435590007080	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
435590007081	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
435590007082	non-specific DNA binding site [nucleotide binding]; other site
435590007083	salt bridge; other site
435590007084	sequence-specific DNA binding site [nucleotide binding]; other site
435590007085	Cupin domain; Region: Cupin_2; cl09118
435590007086	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
435590007087	Lumazine binding domain; Region: Lum_binding; pfam00677
435590007088	Lumazine binding domain; Region: Lum_binding; pfam00677
435590007089	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
435590007090	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
435590007091	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
435590007092	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
435590007093	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
435590007094	HSP70 interaction site [polypeptide binding]; other site
435590007095	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
435590007096	dimer interface [polypeptide binding]; other site
435590007097	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590007098	dimer interface [polypeptide binding]; other site
435590007099	phosphorylation site [posttranslational modification]
435590007100	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590007101	ATP binding site [chemical binding]; other site
435590007102	Mg2+ binding site [ion binding]; other site
435590007103	G-X-G motif; other site
435590007104	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
435590007105	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
435590007106	active site
435590007107	metal binding site [ion binding]; metal-binding site
435590007108	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
435590007109	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590007110	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
435590007111	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
435590007112	N-terminal plug; other site
435590007113	ligand-binding site [chemical binding]; other site
435590007114	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
435590007115	BNR repeat-like domain; Region: BNR_2; pfam13088
435590007116	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
435590007117	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
435590007118	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801
435590007119	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
435590007120	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
435590007121	putative diguanylate cyclase; Provisional; Region: PRK09776
435590007122	adaptive-response sensory kinase; Validated; Region: PRK09303
435590007123	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590007124	dimer interface [polypeptide binding]; other site
435590007125	phosphorylation site [posttranslational modification]
435590007126	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590007127	ATP binding site [chemical binding]; other site
435590007128	Mg2+ binding site [ion binding]; other site
435590007129	G-X-G motif; other site
435590007130	Response regulator receiver domain; Region: Response_reg; pfam00072
435590007131	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590007132	active site
435590007133	phosphorylation site [posttranslational modification]
435590007134	intermolecular recognition site; other site
435590007135	dimerization interface [polypeptide binding]; other site
435590007136	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
435590007137	Protein of unknown function, DUF417; Region: DUF417; cl01162
435590007138	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
435590007139	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
435590007140	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
435590007141	protein binding site [polypeptide binding]; other site
435590007142	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
435590007143	protein binding site [polypeptide binding]; other site
435590007144	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
435590007145	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
435590007146	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590007147	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
435590007148	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590007149	DNA binding residues [nucleotide binding]
435590007150	Clostripain family; Region: Peptidase_C11; cl04055
435590007151	manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845
435590007152	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
435590007153	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
435590007154	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
435590007155	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
435590007156	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
435590007157	MatE; Region: MatE; cl10513
435590007158	MatE; Region: MatE; cl10513
435590007159	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
435590007160	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
435590007161	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
435590007162	motif II; other site
435590007163	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
435590007164	oligomerization interface [polypeptide binding]; other site
435590007165	active site
435590007166	metal binding site [ion binding]; metal-binding site
435590007167	Major Facilitator Superfamily; Region: MFS_1; pfam07690
435590007168	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590007169	putative substrate translocation pore; other site
435590007170	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
435590007171	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
435590007172	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
435590007173	ABC transporter; Region: ABC_tran_2; pfam12848
435590007174	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
435590007175	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590007176	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590007177	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
435590007178	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590007179	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
435590007180	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
435590007181	N-terminal plug; other site
435590007182	ligand-binding site [chemical binding]; other site
435590007183	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
435590007184	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
435590007185	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
435590007186	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
435590007187	Ferritin-like domain; Region: Ferritin; pfam00210
435590007188	ferroxidase diiron center [ion binding]; other site
435590007189	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
435590007190	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
435590007191	OPT oligopeptide transporter protein; Region: OPT; cl14607
435590007192	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
435590007193	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
435590007194	active site
435590007195	metal binding site [ion binding]; metal-binding site
435590007196	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
435590007197	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526
435590007198	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
435590007199	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
435590007200	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
435590007201	synthetase active site [active]
435590007202	NTP binding site [chemical binding]; other site
435590007203	metal binding site [ion binding]; metal-binding site
435590007204	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
435590007205	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
435590007206	Domain of unknown function (DUF4301); Region: DUF4301; pfam14134
435590007207	Peptide-N-glycosidase F, N terminal; Region: N-glycanase_N; pfam09112
435590007208	Peptide-N-glycosidase F, C terminal; Region: N-glycanase_C; pfam09113
435590007209	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
435590007210	A new structural DNA glycosylase; Region: AlkD_like; cd06561
435590007211	active site
435590007212	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
435590007213	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
435590007214	Coenzyme A binding pocket [chemical binding]; other site
435590007215	Helix-turn-helix domains; Region: HTH; cl00088
435590007216	PspC domain; Region: PspC; cl00864
435590007217	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
435590007218	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590007219	ATP-grasp domain; Region: ATP-grasp_4; cl03087
435590007220	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
435590007221	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
435590007222	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
435590007223	Imelysin; Region: Peptidase_M75; cl09159
435590007224	Sulfatase; Region: Sulfatase; cl10460
435590007225	Rhomboid family; Region: Rhomboid; cl11446
435590007226	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
435590007227	glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561
435590007228	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801
435590007229	glycogen/starch synthases, ADP-glucose type; Region: glgA; TIGR02095
435590007230	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
435590007231	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
435590007232	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
435590007233	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
435590007234	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
435590007235	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
435590007236	catalytic residue [active]
435590007237	Protein of unknown function (DUF452); Region: DUF452; cl01062
435590007238	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
435590007239	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590007240	S-adenosylmethionine binding site [chemical binding]; other site
435590007241	AAA domain; Region: AAA_26; pfam13500
435590007242	Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109
435590007243	ADP binding site [chemical binding]; other site
435590007244	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
435590007245	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590007246	putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938
435590007247	Walker A/P-loop; other site
435590007248	ATP binding site [chemical binding]; other site
435590007249	Q-loop/lid; other site
435590007250	ABC transporter signature motif; other site
435590007251	Walker B; other site
435590007252	D-loop; other site
435590007253	H-loop/switch region; other site
435590007254	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590007255	Walker A/P-loop; other site
435590007256	ATP binding site [chemical binding]; other site
435590007257	Q-loop/lid; other site
435590007258	ABC transporter signature motif; other site
435590007259	Walker B; other site
435590007260	D-loop; other site
435590007261	H-loop/switch region; other site
435590007262	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
435590007263	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
435590007264	inhibitor site; inhibition site
435590007265	active site
435590007266	dimer interface [polypeptide binding]; other site
435590007267	catalytic residue [active]
435590007268	Sodium:solute symporter family; Region: SSF; cl00456
435590007269	Sodium:solute symporter family; Region: SSF; cl00456
435590007270	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
435590007271	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
435590007272	FMN binding site [chemical binding]; other site
435590007273	substrate binding site [chemical binding]; other site
435590007274	putative catalytic residue [active]
435590007275	Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040
435590007276	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
435590007277	active site
435590007278	homodimer interface [polypeptide binding]; other site
435590007279	homotetramer interface [polypeptide binding]; other site
435590007280	Phosphate-selective porin O and P; Region: Porin_O_P; cl01524
435590007281	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
435590007282	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
435590007283	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590007284	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
435590007285	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
435590007286	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
435590007287	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
435590007288	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
435590007289	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
435590007290	putative active site [active]
435590007291	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
435590007292	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
435590007293	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
435590007294	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
435590007295	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
435590007296	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
435590007297	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
435590007298	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
435590007299	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
435590007300	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
435590007301	Walker A/P-loop; other site
435590007302	ATP binding site [chemical binding]; other site
435590007303	Q-loop/lid; other site
435590007304	ABC transporter signature motif; other site
435590007305	Walker B; other site
435590007306	D-loop; other site
435590007307	H-loop/switch region; other site
435590007308	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
435590007309	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590007310	FtsX-like permease family; Region: FtsX; cl15850
435590007311	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
435590007312	Histidine kinase; Region: His_kinase; pfam06580
435590007313	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
435590007314	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590007315	active site
435590007316	phosphorylation site [posttranslational modification]
435590007317	intermolecular recognition site; other site
435590007318	dimerization interface [polypeptide binding]; other site
435590007319	LytTr DNA-binding domain; Region: LytTR; cl04498
435590007320	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590007321	Int/Topo IB signature motif; other site
435590007322	active site
435590007323	DNA binding site [nucleotide binding]
435590007324	Peptidase M15; Region: Peptidase_M15_3; cl01194
435590007325	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590007326	DNA binding site [nucleotide binding]
435590007327	Int/Topo IB signature motif; other site
435590007328	active site
435590007329	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
435590007330	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590007331	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590007332	DNA binding residues [nucleotide binding]
435590007333	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
435590007334	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
435590007335	Phage capsid family; Region: Phage_capsid; pfam05065
435590007336	Phage capsid family; Region: Phage_capsid; pfam05065
435590007337	CpXC protein; Region: CpXC; pfam14353
435590007338	Phage portal protein; Region: Phage_portal; pfam04860
435590007339	Phage-related protein [Function unknown]; Region: COG4695; cl01923
435590007340	Phage terminase large subunit; Region: Terminase_3; cl12054
435590007341	Terminase small subunit; Region: Terminase_2; cl01513
435590007342	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
435590007343	extended (e) SDRs; Region: SDR_e; cd08946
435590007344	NAD(P) binding site [chemical binding]; other site
435590007345	active site
435590007346	substrate binding site [chemical binding]; other site
435590007347	Domain of unknown function (DUF3560); Region: DUF3560; pfam12083
435590007348	ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256
435590007349	ParB-like nuclease domain; Region: ParBc; cl02129
435590007350	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
435590007351	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
435590007352	Active Sites [active]
435590007353	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590007354	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
435590007355	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590007356	DNA binding site [nucleotide binding]
435590007357	Int/Topo IB signature motif; other site
435590007358	active site
435590007359	NUMOD4 motif; Region: NUMOD4; pfam07463
435590007360	DNA-directed RNA polymerase subunit A'; Validated; Region: PRK08566
435590007361	PcfJ-like protein; Region: PcfJ; pfam14284
435590007362	PcfK-like protein; Region: PcfK; pfam14058
435590007363	Domain of unknown function (DUF4373); Region: DUF4373; pfam14297
435590007364	Endodeoxyribonuclease RusA; Region: RusA; cl01885
435590007365	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590007366	ATP binding site [chemical binding]; other site
435590007367	putative Mg++ binding site [ion binding]; other site
435590007368	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590007369	nucleotide binding region [chemical binding]; other site
435590007370	ATP-binding site [chemical binding]; other site
435590007371	NinB protein; Region: NinB; cl14671
435590007372	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
435590007373	dimer interface [polypeptide binding]; other site
435590007374	ssDNA binding site [nucleotide binding]; other site
435590007375	tetramer (dimer of dimers) interface [polypeptide binding]; other site
435590007376	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
435590007377	Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936
435590007378	TspO/MBR family; Region: TspO_MBR; cl01379
435590007379	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
435590007380	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
435590007381	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
435590007382	DNA binding residues [nucleotide binding]
435590007383	dimerization interface [polypeptide binding]; other site
435590007384	Cysteine-rich domain; Region: CCG; pfam02754
435590007385	Cysteine-rich domain; Region: CCG; pfam02754
435590007386	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
435590007387	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674
435590007388	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674
435590007389	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
435590007390	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590007391	FeS/SAM binding site; other site
435590007392	Pyruvate formate lyase 1; Region: PFL1; cd01678
435590007393	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
435590007394	coenzyme A binding site [chemical binding]; other site
435590007395	active site
435590007396	catalytic residues [active]
435590007397	glycine loop; other site
435590007398	Transposase; Region: DDE_Tnp_ISL3; pfam01610
435590007399	FeoA domain; Region: FeoA; cl00838
435590007400	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
435590007401	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
435590007402	G1 box; other site
435590007403	GTP/Mg2+ binding site [chemical binding]; other site
435590007404	Switch I region; other site
435590007405	G2 box; other site
435590007406	G3 box; other site
435590007407	Switch II region; other site
435590007408	G4 box; other site
435590007409	G5 box; other site
435590007410	Nucleoside recognition; Region: Gate; cl00486
435590007411	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
435590007412	Nucleoside recognition; Region: Gate; cl00486
435590007413	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
435590007414	Ligand Binding Site [chemical binding]; other site
435590007415	B3/4 domain; Region: B3_4; cl11458
435590007416	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
435590007417	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
435590007418	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590007419	binding surface
435590007420	TPR motif; other site
435590007421	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
435590007422	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
435590007423	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
435590007424	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
435590007425	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
435590007426	Walker A/P-loop; other site
435590007427	ATP binding site [chemical binding]; other site
435590007428	Q-loop/lid; other site
435590007429	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
435590007430	ABC transporter signature motif; other site
435590007431	Walker B; other site
435590007432	D-loop; other site
435590007433	H-loop/switch region; other site
435590007434	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
435590007435	Flavoprotein; Region: Flavoprotein; cl08021
435590007436	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
435590007437	DNA polymerase III subunit epsilon; Validated; Region: PRK06309
435590007438	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
435590007439	active site
435590007440	substrate binding site [chemical binding]; other site
435590007441	catalytic site [active]
435590007442	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
435590007443	DNA polymerase III subunit beta; Validated; Region: PRK05643
435590007444	putative DNA binding surface [nucleotide binding]; other site
435590007445	dimer interface [polypeptide binding]; other site
435590007446	beta-clamp/translesion DNA polymerase binding surface; other site
435590007447	beta-clamp/clamp loader binding surface; other site
435590007448	Domain of unknown function (DUF3127); Region: DUF3127; pfam11325
435590007449	Domain of unknown function (DUF4270); Region: DUF4270; pfam14092
435590007450	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
435590007451	Pantoate-beta-alanine ligase; Region: PanC; cd00560
435590007452	pantoate--beta-alanine ligase; Region: panC; TIGR00018
435590007453	active site
435590007454	ATP-binding site [chemical binding]; other site
435590007455	pantoate-binding site; other site
435590007456	HXXH motif; other site
435590007457	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
435590007458	tetramerization interface [polypeptide binding]; other site
435590007459	active site
435590007460	Transposase domain (DUF772); Region: DUF772; cl15789
435590007461	Transposase domain (DUF772); Region: DUF772; cl15789
435590007462	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
435590007463	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
435590007464	putative transporter; Validated; Region: PRK03818
435590007465	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
435590007466	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
435590007467	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
435590007468	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
435590007469	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
435590007470	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
435590007471	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
435590007472	putative NADH binding site [chemical binding]; other site
435590007473	putative active site [active]
435590007474	nudix motif; other site
435590007475	putative metal binding site [ion binding]; other site
435590007476	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
435590007477	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
435590007478	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
435590007479	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
435590007480	RNA binding site [nucleotide binding]; other site
435590007481	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
435590007482	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
435590007483	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
435590007484	Abi-like protein; Region: Abi_2; cl01988
435590007485	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
435590007486	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590007487	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
435590007488	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590007489	Two component regulator propeller; Region: Reg_prop; pfam07494
435590007490	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590007491	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590007492	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590007493	dimer interface [polypeptide binding]; other site
435590007494	phosphorylation site [posttranslational modification]
435590007495	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590007496	ATP binding site [chemical binding]; other site
435590007497	Mg2+ binding site [ion binding]; other site
435590007498	G-X-G motif; other site
435590007499	Response regulator receiver domain; Region: Response_reg; pfam00072
435590007500	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590007501	active site
435590007502	phosphorylation site [posttranslational modification]
435590007503	intermolecular recognition site; other site
435590007504	dimerization interface [polypeptide binding]; other site
435590007505	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590007506	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590007507	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
435590007508	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590007509	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590007510	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590007511	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590007512	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590007513	Pectate lyase; Region: Pec_lyase_C; cl01593
435590007514	Protein of unknown function (DUF3826); Region: DUF3826; pfam12875
435590007515	Pectate lyase; Region: Pec_lyase_C; cl01593
435590007516	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
435590007517	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590007518	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590007519	DNA binding residues [nucleotide binding]
435590007520	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590007521	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590007522	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590007523	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590007524	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590007525	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590007526	Transposase domain (DUF772); Region: DUF772; cl15789
435590007527	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590007528	Transposase domain (DUF772); Region: DUF772; cl15789
435590007529	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590007530	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590007531	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590007532	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590007533	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590007534	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590007535	Transposase domain (DUF772); Region: DUF772; cl15789
435590007536	Transposase domain (DUF772); Region: DUF772; cl15789
435590007537	methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463
435590007538	The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465
435590007539	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
435590007540	putative transporter; Provisional; Region: PRK10484
435590007541	Sodium:solute symporter family; Region: SSF; cl00456
435590007542	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
435590007543	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
435590007544	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
435590007545	B12 binding site [chemical binding]; other site
435590007546	cobalt ligand [ion binding]; other site
435590007547	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
435590007548	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
435590007549	active site
435590007550	homotrimer interface [polypeptide binding]; other site
435590007551	catalytic site [active]
435590007552	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
435590007553	Right handed beta helix region; Region: Beta_helix; pfam13229
435590007554	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
435590007555	transcription termination factor Rho; Provisional; Region: rho; PRK09376
435590007556	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
435590007557	RNA binding site [nucleotide binding]; other site
435590007558	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
435590007559	multimer interface [polypeptide binding]; other site
435590007560	Walker A motif; other site
435590007561	ATP binding site [chemical binding]; other site
435590007562	Walker B motif; other site
435590007563	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
435590007564	homotrimer interaction site [polypeptide binding]; other site
435590007565	putative active site [active]
435590007566	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
435590007567	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
435590007568	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
435590007569	dimer interface [polypeptide binding]; other site
435590007570	active site
435590007571	metal binding site [ion binding]; metal-binding site
435590007572	glutathione binding site [chemical binding]; other site
435590007573	Domain of unknown function (DUF3805); Region: DUF3805; pfam12712
435590007574	Domain of unknown function (DUF3806); Region: DUF3806; pfam12713
435590007575	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
435590007576	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590007577	Walker A/P-loop; other site
435590007578	ATP binding site [chemical binding]; other site
435590007579	Q-loop/lid; other site
435590007580	ABC transporter signature motif; other site
435590007581	Walker B; other site
435590007582	D-loop; other site
435590007583	H-loop/switch region; other site
435590007584	ABC transporter; Region: ABC_tran_2; pfam12848
435590007585	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
435590007586	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
435590007587	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590007588	DNA binding site [nucleotide binding]
435590007589	Int/Topo IB signature motif; other site
435590007590	active site
435590007591	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766
435590007592	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
435590007593	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
435590007594	Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035
435590007595	4Fe-4S binding domain; Region: Fer4; cl02805
435590007596	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
435590007597	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
435590007598	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
435590007599	active site
435590007600	homodimer interface [polypeptide binding]; other site
435590007601	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u8; cd10932
435590007602	NodB motif; other site
435590007603	putative active site [active]
435590007604	putative catalytic site [active]
435590007605	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
435590007606	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
435590007607	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
435590007608	active site
435590007609	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
435590007610	substrate binding site; other site
435590007611	dimer interface; other site
435590007612	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590007613	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
435590007614	NAD(P) binding site [chemical binding]; other site
435590007615	active site
435590007616	LicD family; Region: LicD; cl01378
435590007617	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
435590007618	Probable Catalytic site; other site
435590007619	metal-binding site
435590007620	extended (e) SDRs; Region: SDR_e; cd08946
435590007621	NAD(P) binding site [chemical binding]; other site
435590007622	active site
435590007623	substrate binding site [chemical binding]; other site
435590007624	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
435590007625	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
435590007626	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
435590007627	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
435590007628	amidase catalytic site [active]
435590007629	Zn binding residues [ion binding]; other site
435590007630	substrate binding site [chemical binding]; other site
435590007631	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
435590007632	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
435590007633	VirE N-terminal domain; Region: VirE_N; pfam08800
435590007634	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
435590007635	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
435590007636	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
435590007637	metal binding triad [ion binding]; metal-binding site
435590007638	HEPN domain; Region: HEPN; cl00824
435590007639	DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095
435590007640	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590007641	ATP binding site [chemical binding]; other site
435590007642	putative Mg++ binding site [ion binding]; other site
435590007643	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590007644	nucleotide binding region [chemical binding]; other site
435590007645	ATP-binding site [chemical binding]; other site
435590007646	Predicted GTPase [General function prediction only]; Region: COG0218
435590007647	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
435590007648	G1 box; other site
435590007649	GTP/Mg2+ binding site [chemical binding]; other site
435590007650	Switch I region; other site
435590007651	G2 box; other site
435590007652	G3 box; other site
435590007653	Switch II region; other site
435590007654	G4 box; other site
435590007655	G5 box; other site
435590007656	Sodium:solute symporter family; Region: SSF; cl00456
435590007657	recombination protein RecR; Reviewed; Region: recR; PRK00076
435590007658	RecR protein; Region: RecR; pfam02132
435590007659	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
435590007660	putative active site [active]
435590007661	putative metal-binding site [ion binding]; other site
435590007662	tetramer interface [polypeptide binding]; other site
435590007663	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
435590007664	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
435590007665	Uncharacterized ACR, COG1678; Region: DUF179; cl00731
435590007666	Gram-negative bacterial tonB protein; Region: TonB; cl10048
435590007667	Domain of unknown function (DUF1858); Region: DUF1858; cl14817
435590007668	iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652
435590007669	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
435590007670	hybrid cluster protein; Provisional; Region: PRK05290
435590007671	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
435590007672	ACS interaction site; other site
435590007673	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
435590007674	hybrid metal cluster; other site
435590007675	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
435590007676	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
435590007677	ligand binding site [chemical binding]; other site
435590007678	flexible hinge region; other site
435590007679	Helix-turn-helix domains; Region: HTH; cl00088
435590007680	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
435590007681	Sulfatase; Region: Sulfatase; cl10460
435590007682	NigD-like protein; Region: NigD; pfam12667
435590007683	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
435590007684	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590007685	active site
435590007686	phosphorylation site [posttranslational modification]
435590007687	intermolecular recognition site; other site
435590007688	dimerization interface [polypeptide binding]; other site
435590007689	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
435590007690	DNA binding site [nucleotide binding]
435590007691	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
435590007692	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590007693	dimer interface [polypeptide binding]; other site
435590007694	phosphorylation site [posttranslational modification]
435590007695	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590007696	ATP binding site [chemical binding]; other site
435590007697	Mg2+ binding site [ion binding]; other site
435590007698	G-X-G motif; other site
435590007699	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
435590007700	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
435590007701	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
435590007702	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
435590007703	putative active site [active]
435590007704	putative metal binding site [ion binding]; other site
435590007705	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
435590007706	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
435590007707	polyphosphate kinase; Provisional; Region: PRK05443
435590007708	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
435590007709	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
435590007710	Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164
435590007711	domain interface [polypeptide binding]; other site
435590007712	active site
435590007713	catalytic site [active]
435590007714	Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167
435590007715	domain interface [polypeptide binding]; other site
435590007716	active site
435590007717	catalytic site [active]
435590007718	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
435590007719	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
435590007720	M28 Zn-Peptidases; Region: M28_like_4; cd08015
435590007721	metal binding site [ion binding]; metal-binding site
435590007722	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
435590007723	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
435590007724	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
435590007725	alpha subunit interaction interface [polypeptide binding]; other site
435590007726	Walker A motif; other site
435590007727	ATP binding site [chemical binding]; other site
435590007728	Walker B motif; other site
435590007729	inhibitor binding site; inhibition site
435590007730	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
435590007731	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
435590007732	ATP synthase A chain; Region: ATP-synt_A; cl00413
435590007733	ATP synthase subunit C; Region: ATP-synt_C; cl00466
435590007734	Plant ATP synthase F0; Region: YMF19; cl07975
435590007735	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
435590007736	Plant ATP synthase F0; Region: YMF19; cl07975
435590007737	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
435590007738	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
435590007739	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
435590007740	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
435590007741	beta subunit interaction interface [polypeptide binding]; other site
435590007742	Walker A motif; other site
435590007743	ATP binding site [chemical binding]; other site
435590007744	Walker B motif; other site
435590007745	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
435590007746	ATP synthase; Region: ATP-synt; cl00365
435590007747	F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422
435590007748	Methyltransferase domain; Region: Methyltransf_31; pfam13847
435590007749	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590007750	S-adenosylmethionine binding site [chemical binding]; other site
435590007751	regulatory ATPase RavA; Provisional; Region: PRK13531
435590007752	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590007753	Walker A motif; other site
435590007754	ATP binding site [chemical binding]; other site
435590007755	Walker B motif; other site
435590007756	arginine finger; other site
435590007757	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425
435590007758	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
435590007759	metal ion-dependent adhesion site (MIDAS); other site
435590007760	Phosphate-selective porin O and P; Region: Porin_O_P; cl01524
435590007761	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
435590007762	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
435590007763	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
435590007764	catalytic residue [active]
435590007765	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
435590007766	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
435590007767	motif II; other site
435590007768	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
435590007769	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590007770	Family description; Region: UvrD_C_2; cl15862
435590007771	Protein of unknown function (DUF3584); Region: DUF3584; pfam12128
435590007772	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
435590007773	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
435590007774	dimer interface [polypeptide binding]; other site
435590007775	active site
435590007776	metal binding site [ion binding]; metal-binding site
435590007777	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
435590007778	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
435590007779	Potassium binding sites [ion binding]; other site
435590007780	Cesium cation binding sites [ion binding]; other site
435590007781	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
435590007782	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
435590007783	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
435590007784	glycine dehydrogenase; Provisional; Region: PRK05367
435590007785	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
435590007786	tetramer interface [polypeptide binding]; other site
435590007787	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590007788	catalytic residue [active]
435590007789	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
435590007790	tetramer interface [polypeptide binding]; other site
435590007791	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590007792	catalytic residue [active]
435590007793	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
435590007794	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590007795	S-adenosylmethionine binding site [chemical binding]; other site
435590007796	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
435590007797	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
435590007798	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
435590007799	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
435590007800	metal-binding site [ion binding]
435590007801	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
435590007802	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
435590007803	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
435590007804	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
435590007805	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
435590007806	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
435590007807	AMP-binding enzyme; Region: AMP-binding; cl15778
435590007808	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
435590007809	Domain of unknown function (DUF4286); Region: DUF4286; pfam14114
435590007810	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529
435590007811	putative DNA-binding cleft [nucleotide binding]; other site
435590007812	dimer interface [polypeptide binding]; other site
435590007813	active site
435590007814	pullulanase, type I; Region: pulA_typeI; TIGR02104
435590007815	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
435590007816	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
435590007817	Ca binding site [ion binding]; other site
435590007818	active site
435590007819	catalytic site [active]
435590007820	mannonate dehydratase; Provisional; Region: PRK03906
435590007821	mannonate dehydratase; Region: uxuA; TIGR00695
435590007822	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
435590007823	active site
435590007824	nucleophile elbow; other site
435590007825	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
435590007826	Surface antigen; Region: Bac_surface_Ag; cl03097
435590007827	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
435590007828	active site
435590007829	substrate binding site [chemical binding]; other site
435590007830	catalytic site [active]
435590007831	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
435590007832	Phosphate-selective porin O and P; Region: Porin_O_P; cl01524
435590007833	excinuclease ABC subunit B; Provisional; Region: PRK05298
435590007834	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590007835	ATP binding site [chemical binding]; other site
435590007836	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590007837	nucleotide binding region [chemical binding]; other site
435590007838	ATP-binding site [chemical binding]; other site
435590007839	Ultra-violet resistance protein B; Region: UvrB; pfam12344
435590007840	UvrB/uvrC motif; Region: UVR; pfam02151
435590007841	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
435590007842	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
435590007843	Domain of unknown function (DUF4293); Region: DUF4293; pfam14126
435590007844	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
435590007845	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
435590007846	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
435590007847	putative peptidoglycan binding site; other site
435590007848	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
435590007849	putative peptidoglycan binding site; other site
435590007850	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
435590007851	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
435590007852	putative peptidoglycan binding site; other site
435590007853	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
435590007854	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
435590007855	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
435590007856	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
435590007857	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
435590007858	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
435590007859	putative deacylase active site [active]
435590007860	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
435590007861	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
435590007862	Membrane protein of unknown function (DUF340); Region: DUF340; cl01028
435590007863	Domain of unknown function (DUF4373); Region: DUF4373; pfam14297
435590007864	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
435590007865	SAF domain; Region: SAF; cl00555
435590007866	Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721
435590007867	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
435590007868	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
435590007869	DNA binding site [nucleotide binding]
435590007870	domain linker motif; other site
435590007871	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
435590007872	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
435590007873	ligand binding site [chemical binding]; other site
435590007874	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
435590007875	substrate binding site [chemical binding]; other site
435590007876	ATP binding site [chemical binding]; other site
435590007877	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
435590007878	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
435590007879	active site
435590007880	intersubunit interface [polypeptide binding]; other site
435590007881	catalytic residue [active]
435590007882	Peptidase family M48; Region: Peptidase_M48; cl12018
435590007883	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590007884	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590007885	isoleucyl-tRNA synthetase; Region: ileS; TIGR00392
435590007886	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
435590007887	HIGH motif; other site
435590007888	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
435590007889	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
435590007890	active site
435590007891	KMSKS motif; other site
435590007892	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
435590007893	tRNA binding surface [nucleotide binding]; other site
435590007894	anticodon binding site; other site
435590007895	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
435590007896	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
435590007897	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
435590007898	lipoprotein signal peptidase; Provisional; Region: PRK14787
435590007899	Domain of unknown function (DUF4296); Region: DUF4296; pfam14129
435590007900	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
435590007901	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
435590007902	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
435590007903	Surface antigen; Region: Bac_surface_Ag; cl03097
435590007904	Protein of unknown function (DUF3829); Region: DUF3829; pfam12889
435590007905	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
435590007906	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
435590007907	DNA binding site [nucleotide binding]
435590007908	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
435590007909	catalytic residues [active]
435590007910	Glucuronate isomerase; Region: UxaC; cl00829
435590007911	altronate oxidoreductase; Provisional; Region: PRK03643
435590007912	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
435590007913	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
435590007914	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
435590007915	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
435590007916	Periplasmic binding protein TroA_d.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141
435590007917	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
435590007918	putative ligand binding site [chemical binding]; other site
435590007919	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
435590007920	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
435590007921	ABC-ATPase subunit  interface; other site
435590007922	dimer interface [polypeptide binding]; other site
435590007923	putative PBP binding regions; other site
435590007924	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
435590007925	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
435590007926	Walker A/P-loop; other site
435590007927	ATP binding site [chemical binding]; other site
435590007928	Q-loop/lid; other site
435590007929	ABC transporter signature motif; other site
435590007930	Walker B; other site
435590007931	D-loop; other site
435590007932	H-loop/switch region; other site
435590007933	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922
435590007934	CbiD; Region: CbiD; cl00828
435590007935	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
435590007936	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
435590007937	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
435590007938	Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133
435590007939	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
435590007940	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
435590007941	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
435590007942	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
435590007943	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590007944	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
435590007945	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
435590007946	Precorrin-8X methylmutase; Region: CbiC; pfam02570
435590007947	Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913
435590007948	Flavin Reductases; Region: FlaRed; cl00801
435590007949	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
435590007950	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
435590007951	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
435590007952	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
435590007953	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
435590007954	Coenzyme A binding pocket [chemical binding]; other site
435590007955	Protein of unknown function (DUF3795); Region: DUF3795; pfam12675
435590007956	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590007957	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590007958	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590007959	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590007960	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315
435590007961	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
435590007962	TPP-binding site; other site
435590007963	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
435590007964	PYR/PP interface [polypeptide binding]; other site
435590007965	dimer interface [polypeptide binding]; other site
435590007966	TPP binding site [chemical binding]; other site
435590007967	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
435590007968	Periplasmic binding protein TroA_d.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141
435590007969	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
435590007970	putative ligand binding site [chemical binding]; other site
435590007971	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590007972	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
435590007973	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
435590007974	N-terminal plug; other site
435590007975	ligand-binding site [chemical binding]; other site
435590007976	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590007977	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
435590007978	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
435590007979	N-terminal plug; other site
435590007980	ligand-binding site [chemical binding]; other site
435590007981	Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219
435590007982	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
435590007983	FAD binding site [chemical binding]; other site
435590007984	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
435590007985	dimer interface [polypeptide binding]; other site
435590007986	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
435590007987	putative radical transfer pathway; other site
435590007988	diiron center [ion binding]; other site
435590007989	tyrosyl radical; other site
435590007990	ribonucleotide-diphosphate reductase subunit alpha; Provisional; Region: PRK12364
435590007991	ATP cone domain; Region: ATP-cone; pfam03477
435590007992	Class I ribonucleotide reductase; Region: RNR_I; cd01679
435590007993	active site
435590007994	dimer interface [polypeptide binding]; other site
435590007995	catalytic residues [active]
435590007996	effector binding site; other site
435590007997	R2 peptide binding site; other site
435590007998	RNA polymerase sigma factor; Provisional; Region: PRK12546
435590007999	Putative cyclase; Region: Cyclase; cl00814
435590008000	putative transporter; Validated; Region: PRK03818
435590008001	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
435590008002	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
435590008003	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
435590008004	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
435590008005	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
435590008006	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
435590008007	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
435590008008	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
435590008009	carboxyltransferase (CT) interaction site; other site
435590008010	biotinylation site [posttranslational modification]; other site
435590008011	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
435590008012	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
435590008013	ATP-grasp domain; Region: ATP-grasp_4; cl03087
435590008014	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
435590008015	ATP cone domain; Region: ATP-cone; pfam03477
435590008016	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08271
435590008017	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
435590008018	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
435590008019	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
435590008020	Cobalt chelatase (CbiK); Region: CbiK; pfam06180
435590008021	active site
435590008022	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
435590008023	active site
435590008024	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
435590008025	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
435590008026	N-terminal plug; other site
435590008027	ligand-binding site [chemical binding]; other site
435590008028	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590008029	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
435590008030	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
435590008031	N-terminal plug; other site
435590008032	ligand-binding site [chemical binding]; other site
435590008033	putative transporter; Validated; Region: PRK03818
435590008034	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
435590008035	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
435590008036	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
435590008037	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
435590008038	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
435590008039	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590008040	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
435590008041	catalytic triad [active]
435590008042	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
435590008043	cobyric acid synthase; Provisional; Region: PRK00784
435590008044	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590008045	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590008046	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
435590008047	catalytic triad [active]
435590008048	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
435590008049	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
435590008050	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590008051	homodimer interface [polypeptide binding]; other site
435590008052	catalytic residue [active]
435590008053	CobD/Cbib protein; Region: CobD_Cbib; cl00561
435590008054	Protein of unknown function (DUF3946); Region: DUF3946; pfam13102
435590008055	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590008056	DNA binding site [nucleotide binding]
435590008057	Int/Topo IB signature motif; other site
435590008058	active site
435590008059	Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253
435590008060	DEAD-like helicases superfamily; Region: DEXDc; smart00487
435590008061	Domain of unknown function, B. Theta Gene description (DUF3871); Region: DUF3871; pfam12987
435590008062	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
435590008063	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
435590008064	Transposase domain (DUF772); Region: DUF772; cl15789
435590008065	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590008066	Transposase domain (DUF772); Region: DUF772; cl15789
435590008067	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
435590008068	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590008069	Protein of unknown function (DUF1622); Region: DUF1622; cl01991
435590008070	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
435590008071	catalytic core [active]
435590008072	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
435590008073	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
435590008074	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
435590008075	active site pocket [active]
435590008076	putative dimer interface [polypeptide binding]; other site
435590008077	putative cataytic base [active]
435590008078	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
435590008079	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
435590008080	homotrimer interface [polypeptide binding]; other site
435590008081	Walker A motif; other site
435590008082	GTP binding site [chemical binding]; other site
435590008083	Walker B motif; other site
435590008084	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
435590008085	phosphopeptide binding site; other site
435590008086	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147
435590008087	Sporulation related domain; Region: SPOR; cl10051
435590008088	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
435590008089	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590008090	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
435590008091	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590008092	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
435590008093	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
435590008094	ATP binding site [chemical binding]; other site
435590008095	Mg++ binding site [ion binding]; other site
435590008096	motif III; other site
435590008097	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590008098	nucleotide binding region [chemical binding]; other site
435590008099	ATP-binding site [chemical binding]; other site
435590008100	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
435590008101	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
435590008102	phosphoserine phosphatase SerB; Region: serB; TIGR00338
435590008103	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
435590008104	motif II; other site
435590008105	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
435590008106	catalytic residues [active]
435590008107	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
435590008108	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
435590008109	motif II; other site
435590008110	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
435590008111	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
435590008112	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
435590008113	tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449
435590008114	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
435590008115	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590008116	Walker A motif; other site
435590008117	ATP binding site [chemical binding]; other site
435590008118	Walker B motif; other site
435590008119	arginine finger; other site
435590008120	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
435590008121	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
435590008122	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590008123	S-adenosylmethionine binding site [chemical binding]; other site
435590008124	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
435590008125	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
435590008126	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
435590008127	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
435590008128	substrate-cofactor binding pocket; other site
435590008129	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590008130	catalytic residue [active]
435590008131	Predicted permeases [General function prediction only]; Region: RarD; COG2962
435590008132	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590008133	FtsX-like permease family; Region: FtsX; cl15850
435590008134	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
435590008135	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
435590008136	Walker A/P-loop; other site
435590008137	ATP binding site [chemical binding]; other site
435590008138	Q-loop/lid; other site
435590008139	ABC transporter signature motif; other site
435590008140	Walker B; other site
435590008141	D-loop; other site
435590008142	H-loop/switch region; other site
435590008143	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590008144	FtsX-like permease family; Region: FtsX; cl15850
435590008145	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590008146	FtsX-like permease family; Region: FtsX; cl15850
435590008147	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590008148	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
435590008149	FtsX-like permease family; Region: FtsX; cl15850
435590008150	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590008151	FtsX-like permease family; Region: FtsX; cl15850
435590008152	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
435590008153	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
435590008154	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
435590008155	Sel1 repeat; Region: Sel1; cl02723
435590008156	Sel1 repeat; Region: Sel1; cl02723
435590008157	Sel1 repeat; Region: Sel1; cl02723
435590008158	Sel1 repeat; Region: Sel1; cl02723
435590008159	Sel1 repeat; Region: Sel1; cl02723
435590008160	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
435590008161	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590008162	active site
435590008163	phosphorylation site [posttranslational modification]
435590008164	intermolecular recognition site; other site
435590008165	dimerization interface [polypeptide binding]; other site
435590008166	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590008167	Walker A motif; other site
435590008168	ATP binding site [chemical binding]; other site
435590008169	Walker B motif; other site
435590008170	arginine finger; other site
435590008171	Helix-turn-helix domains; Region: HTH; cl00088
435590008172	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
435590008173	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590008174	ATP binding site [chemical binding]; other site
435590008175	Mg2+ binding site [ion binding]; other site
435590008176	G-X-G motif; other site
435590008177	Protein of unknown function (DUF3946); Region: DUF3946; pfam13102
435590008178	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590008179	DNA binding site [nucleotide binding]
435590008180	Int/Topo IB signature motif; other site
435590008181	active site
435590008182	Domain of unknown function, B. Theta Gene description (DUF3871); Region: DUF3871; pfam12987
435590008183	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
435590008184	MPN+ (JAMM) motif; other site
435590008185	Zinc-binding site [ion binding]; other site
435590008186	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
435590008187	catalytic residues [active]
435590008188	catalytic nucleophile [active]
435590008189	Domain of unknown function (DUF4405); Region: DUF4405; pfam14358
435590008190	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
435590008191	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
435590008192	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
435590008193	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
435590008194	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
435590008195	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
435590008196	Bacteroidetes-Associated Carbohydrate-binding Often N-terminal; Region: BACON; pfam13004
435590008197	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
435590008198	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
435590008199	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
435590008200	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590008201	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590008202	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
435590008203	Walker A motif; other site
435590008204	ATP binding site [chemical binding]; other site
435590008205	Walker B motif; other site
435590008206	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
435590008207	Integrase core domain; Region: rve; cl01316
435590008208	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590008209	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590008210	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590008211	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590008212	SusD family; Region: SusD; pfam07980
435590008213	Ion channel; Region: Ion_trans_2; cl11596
435590008214	Transposase, Mutator family; Region: Transposase_mut; pfam00872
435590008215	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
435590008216	NVEALA protein; Region: NVEALA; pfam14055
435590008217	KilA-N domain; Region: KilA-N; pfam04383
435590008218	Glycosyl transferase family 11; Region: Glyco_transf_11; pfam01531
435590008219	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
435590008220	Mechanosensitive ion channel; Region: MS_channel; pfam00924
435590008221	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
435590008222	Ion transport protein; Region: Ion_trans; pfam00520
435590008223	Ion channel; Region: Ion_trans_2; cl11596
435590008224	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
435590008225	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
435590008226	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
435590008227	Protein of unknown function (DUF2023); Region: DUF2023; pfam09633
435590008228	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
435590008229	catalytic residues [active]
435590008230	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
435590008231	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
435590008232	dimer interface [polypeptide binding]; other site
435590008233	anticodon binding site; other site
435590008234	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
435590008235	homodimer interface [polypeptide binding]; other site
435590008236	motif 1; other site
435590008237	active site
435590008238	motif 2; other site
435590008239	GAD domain; Region: GAD; pfam02938
435590008240	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
435590008241	motif 3; other site
435590008242	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
435590008243	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
435590008244	DNA binding site [nucleotide binding]
435590008245	active site
435590008246	Domain of unknown function (DUF4251); Region: DUF4251; pfam14059
435590008247	N-carbamolyputrescine amidase; Region: PLN02747
435590008248	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
435590008249	putative active site; other site
435590008250	catalytic triad [active]
435590008251	putative dimer interface [polypeptide binding]; other site
435590008252	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113
435590008253	agmatine deiminase; Region: agmatine_aguA; TIGR03380
435590008254	Family of unknown function (DUF490); Region: DUF490; pfam04357
435590008255	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
435590008256	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
435590008257	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
435590008258	trimer interface [polypeptide binding]; other site
435590008259	active site
435590008260	G bulge; other site
435590008261	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
435590008262	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
435590008263	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
435590008264	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
435590008265	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
435590008266	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
435590008267	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
435590008268	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
435590008269	FMN-binding domain; Region: FMN_bind; cl01081
435590008270	Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC [Energy production and conversion]; Region: NqrC; COG2869
435590008271	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
435590008272	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
435590008273	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
435590008274	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
435590008275	catalytic loop [active]
435590008276	iron binding site [ion binding]; other site
435590008277	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
435590008278	FAD binding pocket [chemical binding]; other site
435590008279	FAD binding motif [chemical binding]; other site
435590008280	phosphate binding motif [ion binding]; other site
435590008281	beta-alpha-beta structure motif; other site
435590008282	NAD binding pocket [chemical binding]; other site
435590008283	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
435590008284	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590008285	ATP binding site [chemical binding]; other site
435590008286	putative Mg++ binding site [ion binding]; other site
435590008287	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590008288	nucleotide binding region [chemical binding]; other site
435590008289	ATP-binding site [chemical binding]; other site
435590008290	DbpA RNA binding domain; Region: DbpA; pfam03880
435590008291	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
435590008292	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
435590008293	homodimer interface [polypeptide binding]; other site
435590008294	substrate-cofactor binding pocket; other site
435590008295	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590008296	catalytic residue [active]
435590008297	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
435590008298	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
435590008299	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590008300	Protein of unknown function (DUF1015); Region: DUF1015; cl01715
435590008301	Predicted permeases [General function prediction only]; Region: RarD; COG2962
435590008302	EamA-like transporter family; Region: EamA; cl01037
435590008303	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
435590008304	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
435590008305	active site
435590008306	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
435590008307	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
435590008308	RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590
435590008309	RNA/DNA binding site [nucleotide binding]; other site
435590008310	RRM dimerization site [polypeptide binding]; other site
435590008311	Uncharacterized protein containing a ferredoxin domain [Function unknown]; Region: COG4739
435590008312	Uncharacterized protein containing a ferredoxin domain (DUF2148); Region: DUF2148; pfam09918
435590008313	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
435590008314	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
435590008315	active site
435590008316	motif I; other site
435590008317	motif II; other site
435590008318	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
435590008319	RmuC family; Region: RmuC; pfam02646
435590008320	MgtC family; Region: MgtC; pfam02308
435590008321	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
435590008322	dimerization interface [polypeptide binding]; other site
435590008323	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
435590008324	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590008325	dimer interface [polypeptide binding]; other site
435590008326	phosphorylation site [posttranslational modification]
435590008327	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590008328	ATP binding site [chemical binding]; other site
435590008329	Mg2+ binding site [ion binding]; other site
435590008330	G-X-G motif; other site
435590008331	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
435590008332	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
435590008333	Ligand Binding Site [chemical binding]; other site
435590008334	Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384
435590008335	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
435590008336	dimer interface [polypeptide binding]; other site
435590008337	ADP-ribose binding site [chemical binding]; other site
435590008338	active site
435590008339	nudix motif; other site
435590008340	metal binding site [ion binding]; metal-binding site
435590008341	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590008342	S-adenosylmethionine binding site [chemical binding]; other site
435590008343	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
435590008344	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
435590008345	Coenzyme A binding pocket [chemical binding]; other site
435590008346	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
435590008347	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
435590008348	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
435590008349	putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501
435590008350	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
435590008351	active site
435590008352	homotetramer interface [polypeptide binding]; other site
435590008353	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
435590008354	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
435590008355	substrate binding site [chemical binding]; other site
435590008356	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
435590008357	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
435590008358	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
435590008359	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
435590008360	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
435590008361	motif II; other site
435590008362	K+-transporting ATPase, c chain; Region: KdpC; cl00944
435590008363	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
435590008364	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
435590008365	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
435590008366	Potassium-transporting ATPase A subunit; Region: KdpA; cl00903
435590008367	Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908
435590008368	putative ADP-ribose binding site [chemical binding]; other site
435590008369	putative active site [active]
435590008370	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
435590008371	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590008372	active site
435590008373	phosphorylation site [posttranslational modification]
435590008374	intermolecular recognition site; other site
435590008375	dimerization interface [polypeptide binding]; other site
435590008376	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590008377	Walker B motif; other site
435590008378	arginine finger; other site
435590008379	Helix-turn-helix domains; Region: HTH; cl00088
435590008380	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
435590008381	This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea.  This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily.  The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294
435590008382	Walker A/P-loop; other site
435590008383	ATP binding site [chemical binding]; other site
435590008384	Q-loop/lid; other site
435590008385	ABC transporter signature motif; other site
435590008386	Walker B; other site
435590008387	D-loop; other site
435590008388	H-loop/switch region; other site
435590008389	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
435590008390	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
435590008391	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
435590008392	dimer interface [polypeptide binding]; other site
435590008393	conserved gate region; other site
435590008394	putative PBP binding loops; other site
435590008395	ABC-ATPase subunit interface; other site
435590008396	NMT1-like family; Region: NMT1_2; cl15260
435590008397	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
435590008398	EamA-like transporter family; Region: EamA; cl01037
435590008399	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
435590008400	EamA-like transporter family; Region: EamA; cl01037
435590008401	maltose O-acetyltransferase; Provisional; Region: PRK10092
435590008402	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
435590008403	active site
435590008404	substrate binding site [chemical binding]; other site
435590008405	trimer interface [polypeptide binding]; other site
435590008406	CoA binding site [chemical binding]; other site
435590008407	Protein of unknown function (DUF2582); Region: DUF2582; pfam10771
435590008408	methionine aminopeptidase; Provisional; Region: PRK12318
435590008409	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
435590008410	active site
435590008411	UGMP family protein; Validated; Region: PRK09604
435590008412	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
435590008413	Thymidylate synthase; Region: dTMP_synthase; cl15399
435590008414	Competence-damaged protein; Region: CinA; cl00666
435590008415	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
435590008416	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
435590008417	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
435590008418	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
435590008419	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590008420	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
435590008421	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
435590008422	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590008423	FeS/SAM binding site; other site
435590008424	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
435590008425	IHF dimer interface [polypeptide binding]; other site
435590008426	IHF - DNA interface [nucleotide binding]; other site
435590008427	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
435590008428	IHF dimer interface [polypeptide binding]; other site
435590008429	IHF - DNA interface [nucleotide binding]; other site
435590008430	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107
435590008431	MoxR-like ATPases [General function prediction only]; Region: COG0714
435590008432	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590008433	Walker A motif; other site
435590008434	ATP binding site [chemical binding]; other site
435590008435	Walker B motif; other site
435590008436	arginine finger; other site
435590008437	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
435590008438	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
435590008439	Aerotolerance regulator N-terminal; Region: BatA; cl06567
435590008440	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
435590008441	metal ion-dependent adhesion site (MIDAS); other site
435590008442	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
435590008443	metal ion-dependent adhesion site (MIDAS); other site
435590008444	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590008445	binding surface
435590008446	TPR motif; other site
435590008447	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590008448	Oxygen tolerance; Region: BatD; pfam13584
435590008449	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590008450	binding surface
435590008451	Tetratricopeptide repeat; Region: TPR_16; pfam13432
435590008452	TPR motif; other site
435590008453	PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395
435590008454	active site
435590008455	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
435590008456	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
435590008457	Ligand Binding Site [chemical binding]; other site
435590008458	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
435590008459	Transposase domain (DUF772); Region: DUF772; cl15789
435590008460	Transposase domain (DUF772); Region: DUF772; cl15789
435590008461	DNA gyrase subunit A; Validated; Region: PRK05560
435590008462	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
435590008463	CAP-like domain; other site
435590008464	active site
435590008465	primary dimer interface [polypeptide binding]; other site
435590008466	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
435590008467	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
435590008468	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
435590008469	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
435590008470	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
435590008471	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
435590008472	Clp protease ATP binding subunit; Region: clpC; CHL00095
435590008473	Clp amino terminal domain; Region: Clp_N; pfam02861
435590008474	Clp amino terminal domain; Region: Clp_N; pfam02861
435590008475	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590008476	Walker A motif; other site
435590008477	ATP binding site [chemical binding]; other site
435590008478	Walker B motif; other site
435590008479	arginine finger; other site
435590008480	UvrB/uvrC motif; Region: UVR; pfam02151
435590008481	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590008482	Walker A motif; other site
435590008483	ATP binding site [chemical binding]; other site
435590008484	Walker B motif; other site
435590008485	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
435590008486	heat shock protein 90; Provisional; Region: PRK05218
435590008487	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590008488	ATP binding site [chemical binding]; other site
435590008489	Mg2+ binding site [ion binding]; other site
435590008490	G-X-G motif; other site
435590008491	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
435590008492	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
435590008493	active site
435590008494	nucleophile elbow; other site
435590008495	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
435590008496	dihydrodipicolinate synthase; Region: dapA; TIGR00674
435590008497	dimer interface [polypeptide binding]; other site
435590008498	active site
435590008499	catalytic residue [active]
435590008500	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
435590008501	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
435590008502	nucleotide binding pocket [chemical binding]; other site
435590008503	K-X-D-G motif; other site
435590008504	catalytic site [active]
435590008505	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
435590008506	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
435590008507	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
435590008508	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
435590008509	Dimer interface [polypeptide binding]; other site
435590008510	BRCT sequence motif; other site
435590008511	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
435590008512	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
435590008513	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
435590008514	heterodimer interface [polypeptide binding]; other site
435590008515	active site
435590008516	FMN binding site [chemical binding]; other site
435590008517	homodimer interface [polypeptide binding]; other site
435590008518	substrate binding site [chemical binding]; other site
435590008519	2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543
435590008520	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
435590008521	FAD binding pocket [chemical binding]; other site
435590008522	FAD binding motif [chemical binding]; other site
435590008523	phosphate binding motif [ion binding]; other site
435590008524	beta-alpha-beta structure motif; other site
435590008525	NAD binding pocket [chemical binding]; other site
435590008526	Iron coordination center [ion binding]; other site
435590008527	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
435590008528	sequence-specific DNA binding site [nucleotide binding]; other site
435590008529	salt bridge; other site
435590008530	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
435590008531	DNA polymerase III, delta subunit; Region: holA; TIGR01128
435590008532	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
435590008533	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
435590008534	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
435590008535	Putative zinc ribbon domain; Region: DUF164; pfam02591
435590008536	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
435590008537	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
435590008538	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
435590008539	Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424
435590008540	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
435590008541	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
435590008542	Walker A/P-loop; other site
435590008543	ATP binding site [chemical binding]; other site
435590008544	Q-loop/lid; other site
435590008545	ABC transporter signature motif; other site
435590008546	Walker B; other site
435590008547	D-loop; other site
435590008548	H-loop/switch region; other site
435590008549	prolyl-tRNA synthetase; Provisional; Region: PRK08661
435590008550	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_arch_euk; cd00778
435590008551	dimer interface [polypeptide binding]; other site
435590008552	motif 1; other site
435590008553	active site
435590008554	motif 2; other site
435590008555	motif 3; other site
435590008556	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
435590008557	anticodon binding site; other site
435590008558	zinc-binding site [ion binding]; other site
435590008559	1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296
435590008560	N-terminal Early set domain associated with the catalytic domain of eukaryotic glycogen branching enzyme (also called 1,4 alpha glucan branching enzyme); Region: E_set_GBE_euk_N; cd02854
435590008561	Alpha amylase catalytic domain found in bacterial and eukaryotic branching enzymes; Region: AmyAc_bac_euk_BE; cd11321
435590008562	active site
435590008563	catalytic site [active]
435590008564	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706
435590008565	Domain of unknown function (DUF386); Region: DUF386; cl01047
435590008566	Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374
435590008567	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
435590008568	active site
435590008569	dimerization interface [polypeptide binding]; other site
435590008570	phosphatidylinositol phosphate kinase; Provisional; Region: PLN03185
435590008571	phosphatidylinositol phosphate kinase; Provisional; Region: PLN03185
435590008572	MORN repeat; Region: MORN; cl14787
435590008573	MORN repeat; Region: MORN; cl14787
435590008574	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
435590008575	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
435590008576	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
435590008577	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233
435590008578	catalytic center binding site [active]
435590008579	ATP binding site [chemical binding]; other site
435590008580	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
435590008581	ABC-2 type transporter; Region: ABC2_membrane; cl11417
435590008582	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
435590008583	active site
435590008584	intersubunit interactions; other site
435590008585	catalytic residue [active]
435590008586	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590008587	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590008588	exodeoxyribonuclease X; Provisional; Region: PRK07983
435590008589	Transglycosylase; Region: Transgly; cl07896
435590008590	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
435590008591	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
435590008592	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
435590008593	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590008594	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
435590008595	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
435590008596	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
435590008597	Flavin Reductases; Region: FlaRed; cl00801
435590008598	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
435590008599	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
435590008600	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
435590008601	dimer interface [polypeptide binding]; other site
435590008602	glycine-pyridoxal phosphate binding site [chemical binding]; other site
435590008603	active site
435590008604	folate binding site [chemical binding]; other site
435590008605	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
435590008606	MatE; Region: MatE; cl10513
435590008607	MatE; Region: MatE; cl10513
435590008608	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
435590008609	ligand binding site [chemical binding]; other site
435590008610	Transglycosylase; Region: Transgly; cl07896
435590008611	Protein of unknown function (DUF1460); Region: DUF1460; pfam07313
435590008612	oxaloacetate decarboxylase alpha subunit; Region: oadA; TIGR01108
435590008613	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
435590008614	active site
435590008615	catalytic residues [active]
435590008616	metal binding site [ion binding]; metal-binding site
435590008617	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
435590008618	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
435590008619	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590008620	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
435590008621	Transposase; Region: DDE_Tnp_ISL3; pfam01610
435590008622	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
435590008623	Predicted membrane protein [Function unknown]; Region: COG2860
435590008624	UPF0126 domain; Region: UPF0126; pfam03458
435590008625	UPF0126 domain; Region: UPF0126; pfam03458
435590008626	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
435590008627	active site
435590008628	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
435590008629	homodimer interface [polypeptide binding]; other site
435590008630	Protein of unknown function (DUF3078); Region: DUF3078; pfam11276
435590008631	CTP synthetase; Validated; Region: pyrG; PRK05380
435590008632	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
435590008633	Catalytic site [active]
435590008634	active site
435590008635	UTP binding site [chemical binding]; other site
435590008636	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
435590008637	active site
435590008638	putative oxyanion hole; other site
435590008639	catalytic triad [active]
435590008640	membrane protein insertase; Provisional; Region: PRK01318
435590008641	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
435590008642	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
435590008643	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
435590008644	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
435590008645	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
435590008646	RNA binding surface [nucleotide binding]; other site
435590008647	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
435590008648	active site
435590008649	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
435590008650	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590008651	S-adenosylmethionine binding site [chemical binding]; other site
435590008652	pyruvate phosphate dikinase; Provisional; Region: PRK09279
435590008653	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
435590008654	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
435590008655	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
435590008656	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
435590008657	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590008658	DNA binding site [nucleotide binding]
435590008659	Int/Topo IB signature motif; other site
435590008660	active site
435590008661	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
435590008662	Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584
435590008663	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
435590008664	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
435590008665	P-loop; other site
435590008666	Magnesium ion binding site [ion binding]; other site
435590008667	Domain of unknown function (DUF4134); Region: DUF4134; pfam13572
435590008668	Bacteroides conjugation system ATPase, TraG family; Region: Bac_Flav_CT_G; TIGR03783
435590008669	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590008670	Walker A motif; other site
435590008671	ATP binding site [chemical binding]; other site
435590008672	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
435590008673	Bacteroides conjugation system ATPase, TraG family; Region: Bac_Flav_CT_G; TIGR03783
435590008674	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
435590008675	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
435590008676	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
435590008677	putative active site [active]
435590008678	putative NTP binding site [chemical binding]; other site
435590008679	putative nucleic acid binding site [nucleotide binding]; other site
435590008680	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
435590008681	Bacteroides conjugation system ATPase, TraG family; Region: Bac_Flav_CT_G; TIGR03783
435590008682	Bacteroides conjugative transposon TraJ protein; Region: Bac_Flav_CT_J; TIGR03782
435590008683	Bacteroides conjugative transposon TraK protein; Region: Bac_Flav_CT_K; TIGR03781
435590008684	Protein of unknown function (DUF3714); Region: DUF3714; pfam12508
435590008685	Domain of unknown function (DUF4138); Region: DUF4138; pfam13595
435590008686	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590008687	Walker B motif; other site
435590008688	TraX protein; Region: TraX; cl05434
435590008689	Protein of unknown function (DUF4099); Region: DUF4099; pfam13351
435590008690	Protein of unknown function (DUF3945); Region: DUF3945; pfam13101
435590008691	MutS domain I; Region: MutS_I; pfam01624
435590008692	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
435590008693	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
435590008694	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
435590008695	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
435590008696	DNA topoisomerase III; Validated; Region: PRK08173
435590008697	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
435590008698	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
435590008699	PcfK-like protein; Region: PcfK; pfam14058
435590008700	DNA directed RNA polymerase, 7 kDa subunit; Region: DNA_RNApol_7kD; cl00874
435590008701	PcfJ-like protein; Region: PcfJ; pfam14284
435590008702	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
435590008703	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
435590008704	P-loop; other site
435590008705	Magnesium ion binding site [ion binding]; other site
435590008706	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
435590008707	Magnesium ion binding site [ion binding]; other site
435590008708	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
435590008709	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
435590008710	active site
435590008711	HIRAN domain; Region: HIRAN; cl07418
435590008712	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
435590008713	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
435590008714	active site
435590008715	motif I; other site
435590008716	motif II; other site
435590008717	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
435590008718	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
435590008719	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
435590008720	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
435590008721	DNA binding site [nucleotide binding]
435590008722	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590008723	Family description; Region: UvrD_C_2; cl15862
435590008724	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
435590008725	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
435590008726	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590008727	ATP binding site [chemical binding]; other site
435590008728	putative Mg++ binding site [ion binding]; other site
435590008729	Protein of unknown function DUF262; Region: DUF262; cl14890
435590008730	Protein of unknown function DUF262; Region: DUF262; cl14890
435590008731	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
435590008732	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
435590008733	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
435590008734	HsdM N-terminal domain; Region: HsdM_N; pfam12161
435590008735	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
435590008736	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590008737	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
435590008738	non-specific DNA binding site [nucleotide binding]; other site
435590008739	salt bridge; other site
435590008740	sequence-specific DNA binding site [nucleotide binding]; other site
435590008741	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
435590008742	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
435590008743	Protein of unknown function (DUF1273); Region: DUF1273; cl01859
435590008744	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
435590008745	Catalytic site [active]
435590008746	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
435590008747	non-specific DNA binding site [nucleotide binding]; other site
435590008748	salt bridge; other site
435590008749	sequence-specific DNA binding site [nucleotide binding]; other site
435590008750	HNH endonuclease; Region: HNH_3; pfam13392
435590008751	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
435590008752	IHF - DNA interface [nucleotide binding]; other site
435590008753	IHF dimer interface [polypeptide binding]; other site
435590008754	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
435590008755	Divergent AAA domain; Region: AAA_4; pfam04326
435590008756	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
435590008757	Helix-turn-helix domains; Region: HTH; cl00088
435590008758	CHC2 zinc finger; Region: zf-CHC2; cl15369
435590008759	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
435590008760	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
435590008761	active site
435590008762	metal binding site [ion binding]; metal-binding site
435590008763	interdomain interaction site; other site
435590008764	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
435590008765	Peptidase C26; Region: Peptidase_C26; pfam07722
435590008766	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
435590008767	catalytic triad [active]
435590008768	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
435590008769	active site
435590008770	dimer interface [polypeptide binding]; other site
435590008771	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590008772	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
435590008773	FtsX-like permease family; Region: FtsX; cl15850
435590008774	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590008775	FtsX-like permease family; Region: FtsX; cl15850
435590008776	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
435590008777	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
435590008778	Walker A/P-loop; other site
435590008779	ATP binding site [chemical binding]; other site
435590008780	Q-loop/lid; other site
435590008781	ABC transporter signature motif; other site
435590008782	Walker B; other site
435590008783	D-loop; other site
435590008784	H-loop/switch region; other site
435590008785	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590008786	FtsX-like permease family; Region: FtsX; cl15850
435590008787	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590008788	FtsX-like permease family; Region: FtsX; cl15850
435590008789	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
435590008790	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
435590008791	active site
435590008792	Zn binding site [ion binding]; other site
435590008793	OpgC protein; Region: OpgC_C; cl00792
435590008794	Acyltransferase family; Region: Acyl_transf_3; pfam01757
435590008795	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
435590008796	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
435590008797	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590008798	This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812
435590008799	putative ADP-binding pocket [chemical binding]; other site
435590008800	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
435590008801	Transposase domain (DUF772); Region: DUF772; cl15789
435590008802	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590008803	putative glycosyl transferase; Provisional; Region: PRK10073
435590008804	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
435590008805	active site
435590008806	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
435590008807	trimer interface [polypeptide binding]; other site
435590008808	active site
435590008809	substrate binding site [chemical binding]; other site
435590008810	CoA binding site [chemical binding]; other site
435590008811	Glycosyl transferase family 11; Region: Glyco_transf_11; pfam01531
435590008812	O-Antigen ligase; Region: Wzy_C; cl04850
435590008813	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
435590008814	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
435590008815	active site
435590008816	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
435590008817	MatE; Region: MatE; cl10513
435590008818	MatE; Region: MatE; cl10513
435590008819	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), UpxY; Region: NGN_SP_UpxY; cd09895
435590008820	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
435590008821	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
435590008822	non-specific DNA binding site [nucleotide binding]; other site
435590008823	salt bridge; other site
435590008824	sequence-specific DNA binding site [nucleotide binding]; other site
435590008825	Protein of unknown function (DUF3791); Region: DUF3791; pfam12668
435590008826	Protein of unknown function (DUF3990); Region: DUF3990; pfam13151
435590008827	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
435590008828	catalytic residues [active]
435590008829	dimer interface [polypeptide binding]; other site
435590008830	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
435590008831	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
435590008832	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
435590008833	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590008834	active site
435590008835	phosphorylation site [posttranslational modification]
435590008836	intermolecular recognition site; other site
435590008837	dimerization interface [polypeptide binding]; other site
435590008838	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590008839	Walker A motif; other site
435590008840	ATP binding site [chemical binding]; other site
435590008841	Walker B motif; other site
435590008842	arginine finger; other site
435590008843	Helix-turn-helix domains; Region: HTH; cl00088
435590008844	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
435590008845	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590008846	ATP binding site [chemical binding]; other site
435590008847	Mg2+ binding site [ion binding]; other site
435590008848	G-X-G motif; other site
435590008849	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
435590008850	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590008851	Family description; Region: UvrD_C_2; cl15862
435590008852	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
435590008853	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
435590008854	Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893
435590008855	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
435590008856	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14609
435590008857	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
435590008858	replicative DNA helicase; Region: DnaB; TIGR00665
435590008859	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
435590008860	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
435590008861	Walker A motif; other site
435590008862	ATP binding site [chemical binding]; other site
435590008863	Walker B motif; other site
435590008864	DNA binding loops [nucleotide binding]
435590008865	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
435590008866	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
435590008867	putative tRNA-binding site [nucleotide binding]; other site
435590008868	B3/4 domain; Region: B3_4; cl11458
435590008869	tRNA synthetase B5 domain; Region: B5; cl08394
435590008870	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
435590008871	dimer interface [polypeptide binding]; other site
435590008872	motif 1; other site
435590008873	motif 3; other site
435590008874	motif 2; other site
435590008875	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386
435590008876	Transcriptional regulator; Region: Transcrip_reg; cl00361
435590008877	TSCPD domain; Region: TSCPD; cl14834
435590008878	transposase/IS protein; Provisional; Region: PRK09183
435590008879	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590008880	Walker A motif; other site
435590008881	ATP binding site [chemical binding]; other site
435590008882	Walker B motif; other site
435590008883	arginine finger; other site
435590008884	Helix-turn-helix domains; Region: HTH; cl00088
435590008885	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
435590008886	Integrase core domain; Region: rve; cl01316
435590008887	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590008888	Walker A motif; other site
435590008889	ATP binding site [chemical binding]; other site
435590008890	Walker B motif; other site
435590008891	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
435590008892	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
435590008893	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
435590008894	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590008895	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
435590008896	Magnesium ion binding site [ion binding]; other site
435590008897	Protein of unknown function (DUF3988); Region: DUF3988; pfam13149
435590008898	Fic family protein [Function unknown]; Region: COG3177
435590008899	Fic/DOC family; Region: Fic; cl00960
435590008900	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
435590008901	Competence protein CoiA-like family; Region: CoiA; cl11541
435590008902	Transposase; Region: DDE_Tnp_ISL3; pfam01610
435590008903	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
435590008904	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590008905	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590008906	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590008907	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590008908	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
435590008909	ligand binding site [chemical binding]; other site
435590008910	flexible hinge region; other site
435590008911	transposase/IS protein; Provisional; Region: PRK09183
435590008912	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590008913	Walker A motif; other site
435590008914	ATP binding site [chemical binding]; other site
435590008915	Walker B motif; other site
435590008916	Transposase domain (DUF772); Region: DUF772; cl15789
435590008917	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590008918	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
435590008919	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
435590008920	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590008921	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590008922	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590008923	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590008924	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590008925	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
435590008926	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
435590008927	putative active site [active]
435590008928	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
435590008929	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
435590008930	active site
435590008931	dimer interfaces [polypeptide binding]; other site
435590008932	catalytic residues [active]
435590008933	Arginase family; Region: Arginase; cl00306
435590008934	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
435590008935	putative homodimer interface [polypeptide binding]; other site
435590008936	putative active site pocket [active]
435590008937	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
435590008938	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
435590008939	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
435590008940	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
435590008941	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
435590008942	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
435590008943	active site
435590008944	ADP/pyrophosphate binding site [chemical binding]; other site
435590008945	dimerization interface [polypeptide binding]; other site
435590008946	allosteric effector site; other site
435590008947	fructose-1,6-bisphosphate binding site; other site
435590008948	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590008949	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
435590008950	putative dimer interface [polypeptide binding]; other site
435590008951	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
435590008952	catalytic core [active]
435590008953	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
435590008954	fructose-bisphosphate aldolase; Provisional; Region: PRK09250
435590008955	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
435590008956	putative active site; other site
435590008957	catalytic residue [active]
435590008958	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
435590008959	Ferritin-like domain; Region: Ferritin; pfam00210
435590008960	ferroxidase diiron center [ion binding]; other site
435590008961	MarC family integral membrane protein; Region: MarC; cl00919
435590008962	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
435590008963	dinuclear metal binding motif [ion binding]; other site
435590008964	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590008965	FtsX-like permease family; Region: FtsX; cl15850
435590008966	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
435590008967	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590008968	FtsX-like permease family; Region: FtsX; cl15850
435590008969	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
435590008970	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
435590008971	Walker A/P-loop; other site
435590008972	ATP binding site [chemical binding]; other site
435590008973	Q-loop/lid; other site
435590008974	ABC transporter signature motif; other site
435590008975	Walker B; other site
435590008976	D-loop; other site
435590008977	H-loop/switch region; other site
435590008978	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
435590008979	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
435590008980	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
435590008981	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
435590008982	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
435590008983	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590008984	active site
435590008985	phosphorylation site [posttranslational modification]
435590008986	intermolecular recognition site; other site
435590008987	dimerization interface [polypeptide binding]; other site
435590008988	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590008989	Walker A motif; other site
435590008990	ATP binding site [chemical binding]; other site
435590008991	Walker B motif; other site
435590008992	arginine finger; other site
435590008993	Helix-turn-helix domains; Region: HTH; cl00088
435590008994	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
435590008995	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
435590008996	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590008997	ATP binding site [chemical binding]; other site
435590008998	Mg2+ binding site [ion binding]; other site
435590008999	G-X-G motif; other site
435590009000	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
435590009001	Coenzyme A binding pocket [chemical binding]; other site
435590009002	Predicted amidohydrolase [General function prediction only]; Region: COG0388
435590009003	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
435590009004	putative active site [active]
435590009005	catalytic triad [active]
435590009006	putative dimer interface [polypeptide binding]; other site
435590009007	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
435590009008	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
435590009009	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
435590009010	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
435590009011	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
435590009012	dimer interface [polypeptide binding]; other site
435590009013	active site
435590009014	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
435590009015	catalytic residues [active]
435590009016	substrate binding site [chemical binding]; other site
435590009017	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
435590009018	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590009019	Family description; Region: UvrD_C_2; cl15862
435590009020	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
435590009021	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
435590009022	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
435590009023	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
435590009024	thiS-thiF/thiG interaction site; other site
435590009025	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
435590009026	thiamine phosphate binding site [chemical binding]; other site
435590009027	active site
435590009028	pyrophosphate binding site [ion binding]; other site
435590009029	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
435590009030	ThiS interaction site; other site
435590009031	putative active site [active]
435590009032	tetramer interface [polypeptide binding]; other site
435590009033	ThiC-associated domain; Region: ThiC-associated; pfam13667
435590009034	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
435590009035	ThiC family; Region: ThiC; cl08031
435590009036	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
435590009037	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
435590009038	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590009039	FeS/SAM binding site; other site
435590009040	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
435590009041	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
435590009042	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
435590009043	ATP binding site [chemical binding]; other site
435590009044	substrate interface [chemical binding]; other site
435590009045	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503
435590009046	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
435590009047	thiamine phosphate binding site [chemical binding]; other site
435590009048	active site
435590009049	pyrophosphate binding site [ion binding]; other site
435590009050	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
435590009051	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
435590009052	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
435590009053	active site
435590009054	Transposase domain (DUF772); Region: DUF772; cl15789
435590009055	Transposase domain (DUF772); Region: DUF772; cl15789
435590009056	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
435590009057	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
435590009058	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
435590009059	dimer interface [polypeptide binding]; other site
435590009060	conserved gate region; other site
435590009061	putative PBP binding loops; other site
435590009062	ABC-ATPase subunit interface; other site
435590009063	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
435590009064	dimer interface [polypeptide binding]; other site
435590009065	conserved gate region; other site
435590009066	putative PBP binding loops; other site
435590009067	ABC-ATPase subunit interface; other site
435590009068	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
435590009069	PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D.  PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300
435590009070	Walker A/P-loop; other site
435590009071	ATP binding site [chemical binding]; other site
435590009072	Q-loop/lid; other site
435590009073	ABC transporter signature motif; other site
435590009074	Walker B; other site
435590009075	D-loop; other site
435590009076	H-loop/switch region; other site
435590009077	TOBE domain; Region: TOBE_2; cl01440
435590009078	TOBE domain; Region: TOBE_2; cl01440
435590009079	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
435590009080	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
435590009081	catalytic residues [active]
435590009082	Transposase domain (DUF772); Region: DUF772; cl15789
435590009083	Transposase domain (DUF772); Region: DUF772; cl15789
435590009084	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
435590009085	putative homodimer interface [polypeptide binding]; other site
435590009086	putative active site pocket [active]
435590009087	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
435590009088	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
435590009089	Glycogen synthase; Region: Glycogen_syn; pfam05693
435590009090	V-type ATP synthase subunit K; Validated; Region: PRK08344
435590009091	ATP synthase subunit C; Region: ATP-synt_C; cl00466
435590009092	ATP synthase subunit C; Region: ATP-synt_C; cl00466
435590009093	V-type ATP synthase subunit I; Validated; Region: PRK05771
435590009094	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
435590009095	ATP synthase subunit D; Region: ATP-synt_D; cl00613
435590009096	V-type ATP synthase subunit B; Provisional; Region: PRK02118
435590009097	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
435590009098	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
435590009099	Walker A motif homologous position; other site
435590009100	Walker B motif; other site
435590009101	V-type ATP synthase subunit A; Provisional; Region: PRK04192
435590009102	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
435590009103	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
435590009104	Walker A motif/ATP binding site; other site
435590009105	Walker B motif; other site
435590009106	Protein of unknown function (DUF2764); Region: DUF2764; pfam10962
435590009107	Plant ATP synthase F0; Region: YMF19; cl07975
435590009108	ATP synthase (E/31 kDa) subunit; Region: vATP-synt_E; pfam01991
435590009109	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
435590009110	ABC-2 type transporter; Region: ABC2_membrane; cl11417
435590009111	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
435590009112	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
435590009113	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
435590009114	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
435590009115	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
435590009116	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
435590009117	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
435590009118	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
435590009119	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
435590009120	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
435590009121	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
435590009122	ligand binding site [chemical binding]; other site
435590009123	flexible hinge region; other site
435590009124	Helix-turn-helix domains; Region: HTH; cl00088
435590009125	DPS-like protein, ferritin-like diiron-binding domain; Region: DPSL; cd01052
435590009126	Ferritin-like domain; Region: Ferritin; pfam00210
435590009127	diiron binding motif [ion binding]; other site
435590009128	NeuB family; Region: NeuB; cl00496
435590009129	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
435590009130	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
435590009131	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590009132	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
435590009133	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590009134	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
435590009135	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
435590009136	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
435590009137	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
435590009138	GMP synthase; Reviewed; Region: guaA; PRK00074
435590009139	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
435590009140	AMP/PPi binding site [chemical binding]; other site
435590009141	candidate oxyanion hole; other site
435590009142	catalytic triad [active]
435590009143	potential glutamine specificity residues [chemical binding]; other site
435590009144	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
435590009145	ATP Binding subdomain [chemical binding]; other site
435590009146	Ligand Binding sites [chemical binding]; other site
435590009147	Dimerization subdomain; other site
435590009148	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
435590009149	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
435590009150	GMP synthase, PP-ATPase domain/subunit [Nucleotide transport and metabolism]; Region: GuaA; COG0519
435590009151	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
435590009152	ATP Binding subdomain [chemical binding]; other site
435590009153	Ligand Binding sites [chemical binding]; other site
435590009154	Dimerization subdomain; other site
435590009155	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
435590009156	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
435590009157	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
435590009158	active site
435590009159	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
435590009160	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
435590009161	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
435590009162	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
435590009163	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
435590009164	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
435590009165	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
435590009166	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
435590009167	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
435590009168	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
435590009169	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
435590009170	Histidine kinase; Region: His_kinase; pfam06580
435590009171	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590009172	Response regulator receiver domain; Region: Response_reg; pfam00072
435590009173	active site
435590009174	phosphorylation site [posttranslational modification]
435590009175	intermolecular recognition site; other site
435590009176	dimerization interface [polypeptide binding]; other site
435590009177	LytTr DNA-binding domain; Region: LytTR; cl04498
435590009178	Proline dehydrogenase; Region: Pro_dh; cl03282
435590009179	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
435590009180	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
435590009181	Glutamate binding site [chemical binding]; other site
435590009182	NAD binding site [chemical binding]; other site
435590009183	catalytic residues [active]
435590009184	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
435590009185	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590009186	Walker A/P-loop; other site
435590009187	ATP binding site [chemical binding]; other site
435590009188	ABC transporter; Region: ABC_tran; pfam00005
435590009189	Q-loop/lid; other site
435590009190	ABC transporter signature motif; other site
435590009191	Walker B; other site
435590009192	D-loop; other site
435590009193	H-loop/switch region; other site
435590009194	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611
435590009195	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
435590009196	Bifunctional nuclease; Region: DNase-RNase; cl00553
435590009197	UvrB/uvrC motif; Region: UVR; pfam02151
435590009198	nucleoside transporter; Region: 2A0110; TIGR00889
435590009199	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
435590009200	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590009201	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590009202	DNA binding residues [nucleotide binding]
435590009203	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
435590009204	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590009205	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590009206	DNA binding residues [nucleotide binding]
435590009207	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
435590009208	Methyltransferase domain; Region: Methyltransf_31; pfam13847
435590009209	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590009210	S-adenosylmethionine binding site [chemical binding]; other site
435590009211	PUA domain; Region: PUA; cl00607
435590009212	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
435590009213	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590009214	S-adenosylmethionine binding site [chemical binding]; other site
435590009215	DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141
435590009216	putative active site [active]
435590009217	catalytic site [active]
435590009218	putative substrate binding site [chemical binding]; other site
435590009219	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
435590009220	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590009221	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
435590009222	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065
435590009223	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
435590009224	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
435590009225	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
435590009226	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
435590009227	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
435590009228	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
435590009229	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
435590009230	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
435590009231	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
435590009232	Walker A/P-loop; other site
435590009233	ATP binding site [chemical binding]; other site
435590009234	Q-loop/lid; other site
435590009235	ABC transporter signature motif; other site
435590009236	Walker B; other site
435590009237	D-loop; other site
435590009238	H-loop/switch region; other site
435590009239	NlpC/P60 family; Region: NLPC_P60; cl11438
435590009240	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
435590009241	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
435590009242	motif II; other site
435590009243	Protein of unknown function (DUF3667); Region: DUF3667; pfam12412
435590009244	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
435590009245	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
435590009246	Thiamine pyrophosphokinase; Region: TPK; cd07995
435590009247	active site
435590009248	dimerization interface [polypeptide binding]; other site
435590009249	thiamine binding site [chemical binding]; other site
435590009250	Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256
435590009251	seryl-tRNA synthetase; Provisional; Region: PRK05431
435590009252	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
435590009253	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770
435590009254	dimer interface [polypeptide binding]; other site
435590009255	active site
435590009256	motif 1; other site
435590009257	motif 2; other site
435590009258	motif 3; other site
435590009259	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
435590009260	glucose/galactose transporter; Region: gluP; TIGR01272
435590009261	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420
435590009262	putative bifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta; Provisional; Region: PRK12778
435590009263	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
435590009264	FAD binding pocket [chemical binding]; other site
435590009265	FAD binding motif [chemical binding]; other site
435590009266	phosphate binding motif [ion binding]; other site
435590009267	beta-alpha-beta structure motif; other site
435590009268	NAD binding pocket [chemical binding]; other site
435590009269	Iron coordination center [ion binding]; other site
435590009270	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590009271	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
435590009272	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
435590009273	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
435590009274	Ligand Binding Site [chemical binding]; other site
435590009275	TIGR00269 family protein; Region: TIGR00269
435590009276	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590009277	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
435590009278	TPR motif; other site
435590009279	binding surface
435590009280	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
435590009281	SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057
435590009282	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
435590009283	GAF domain; Region: GAF; cl15785
435590009284	GAF domain; Region: GAF_2; pfam13185
435590009285	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
435590009286	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
435590009287	trmE is a tRNA modification GTPase; Region: trmE; cd04164
435590009288	G1 box; other site
435590009289	GTP/Mg2+ binding site [chemical binding]; other site
435590009290	Switch I region; other site
435590009291	G2 box; other site
435590009292	Switch II region; other site
435590009293	G3 box; other site
435590009294	G4 box; other site
435590009295	G5 box; other site
435590009296	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
435590009297	Protein of unknown function (DUF4065); Region: DUF4065; cl01445
435590009298	Protein of unknown function (DUF4065); Region: DUF4065; cl01445
435590009299	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590009300	AAA domain; Region: AAA_21; pfam13304
435590009301	Walker A/P-loop; other site
435590009302	ATP binding site [chemical binding]; other site
435590009303	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
435590009304	Abi-like protein; Region: Abi_2; cl01988
435590009305	Transposase, Mutator family; Region: Transposase_mut; pfam00872
435590009306	Transposase, Mutator family; Region: Transposase_mut; pfam00872
435590009307	Transposase, Mutator family; Region: Transposase_mut; pfam00872
435590009308	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
435590009309	TIR domain; Region: TIR_2; cl15770
435590009310	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924
435590009311	Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795
435590009312	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
435590009313	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
435590009314	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590009315	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
435590009316	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
435590009317	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
435590009318	RloB-like protein; Region: RloB; pfam13707
435590009319	AAA domain; Region: AAA_21; pfam13304
435590009320	RloB-like protein; Region: RloB; pfam13707
435590009321	Predicted ATPases [General function prediction only]; Region: COG1106
435590009322	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590009323	Walker A/P-loop; other site
435590009324	ATP binding site [chemical binding]; other site
435590009325	Q-loop/lid; other site
435590009326	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
435590009327	Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584
435590009328	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
435590009329	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
435590009330	Int/Topo IB signature motif; other site
435590009331	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
435590009332	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
435590009333	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
435590009334	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
435590009335	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
435590009336	Integrase core domain; Region: rve; cl01316
435590009337	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
435590009338	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
435590009339	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
435590009340	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
435590009341	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
435590009342	BRO family, N-terminal domain; Region: Bro-N; cl10591
435590009343	Virulence protein [General function prediction only]; Region: COG3943
435590009344	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
435590009345	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
435590009346	HsdM N-terminal domain; Region: HsdM_N; pfam12161
435590009347	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
435590009348	S-adenosylmethionine binding site [chemical binding]; other site
435590009349	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590009350	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
435590009351	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
435590009352	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590009353	ATP binding site [chemical binding]; other site
435590009354	putative Mg++ binding site [ion binding]; other site
435590009355	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
435590009356	non-specific DNA binding site [nucleotide binding]; other site
435590009357	salt bridge; other site
435590009358	sequence-specific DNA binding site [nucleotide binding]; other site
435590009359	HipA-like N-terminal domain; Region: HipA_N; pfam07805
435590009360	HipA-like C-terminal domain; Region: HipA_C; pfam07804
435590009361	HipA N-terminal domain; Region: Couple_hipA; cl11853
435590009362	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
435590009363	non-specific DNA binding site [nucleotide binding]; other site
435590009364	salt bridge; other site
435590009365	sequence-specific DNA binding site [nucleotide binding]; other site
435590009366	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
435590009367	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590009368	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
435590009369	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590009370	ParB-like nuclease domain; Region: ParBc; cl02129
435590009371	Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969
435590009372	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
435590009373	Active Sites [active]
435590009374	Domain of unknown function (DUF3440); Region: DUF3440; pfam11922
435590009375	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590009376	SusD family; Region: SusD; pfam07980
435590009377	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590009378	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590009379	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590009380	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590009381	Domain of unknown function (DUF4425); Region: DUF4425; pfam14466
435590009382	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590009383	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590009384	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590009385	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590009386	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590009387	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590009388	starch binding outer membrane protein SusD; Region: SusD; cl15876
435590009389	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590009390	Walker A motif; other site
435590009391	ATP binding site [chemical binding]; other site
435590009392	Walker B motif; other site
435590009393	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
435590009394	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108
435590009395	Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185
435590009396	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
435590009397	Int/Topo IB signature motif; other site
435590009398	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
435590009399	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
435590009400	Protein of unknown function (DUF3946); Region: DUF3946; pfam13102
435590009401	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590009402	Int/Topo IB signature motif; other site
435590009403	active site
435590009404	DNA binding site [nucleotide binding]
435590009405	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
435590009406	conserved cys residue [active]
435590009407	Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584
435590009408	Protein of unknown function (DUF3408); Region: DUF3408; pfam11888
435590009409	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
435590009410	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
435590009411	Virulence protein [General function prediction only]; Region: COG3943
435590009412	Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185
435590009413	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
435590009414	Int/Topo IB signature motif; other site
435590009415	Tn4399 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases, including cLV25, a Bacteroides fragilis chromosomal transfer factor integrase similar to the...; Region: INT_Tn4399; cd01185
435590009416	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
435590009417	Int/Topo IB signature motif; other site
435590009418	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
435590009419	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
435590009420	Restriction endonuclease; Region: Mrr_cat; cl00516
435590009421	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
435590009422	non-specific DNA binding site [nucleotide binding]; other site
435590009423	salt bridge; other site
435590009424	sequence-specific DNA binding site [nucleotide binding]; other site
435590009425	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590009426	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590009427	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
435590009428	Divergent AAA domain; Region: AAA_4; pfam04326
435590009429	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
435590009430	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
435590009431	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590009432	ATP binding site [chemical binding]; other site
435590009433	putative Mg++ binding site [ion binding]; other site
435590009434	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590009435	nucleotide binding region [chemical binding]; other site
435590009436	ATP-binding site [chemical binding]; other site
435590009437	PglZ domain; Region: PglZ; pfam08665
435590009438	HIRAN domain; Region: HIRAN; cl07418
435590009439	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
435590009440	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
435590009441	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
435590009442	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590009443	ATP binding site [chemical binding]; other site
435590009444	putative Mg++ binding site [ion binding]; other site
435590009445	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590009446	nucleotide binding region [chemical binding]; other site
435590009447	ATP-binding site [chemical binding]; other site
435590009448	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
435590009449	putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055
435590009450	FeS/SAM binding site; other site
435590009451	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
435590009452	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
435590009453	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
435590009454	oligomer interface [polypeptide binding]; other site
435590009455	active site
435590009456	metal binding site [ion binding]; metal-binding site
435590009457	Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176
435590009458	putative homodimer interface [polypeptide binding]; other site
435590009459	putative active site [active]
435590009460	catalytic site [active]
435590009461	ATP-dependent helicase HepA; Validated; Region: PRK04914
435590009462	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590009463	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
435590009464	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
435590009465	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
435590009466	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
435590009467	MatE; Region: MatE; cl10513
435590009468	MatE; Region: MatE; cl10513
435590009469	HipA N-terminal domain; Region: Couple_hipA; cl11853
435590009470	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
435590009471	HipA-like N-terminal domain; Region: HipA_N; pfam07805
435590009472	HipA-like C-terminal domain; Region: HipA_C; pfam07804
435590009473	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
435590009474	non-specific DNA binding site [nucleotide binding]; other site
435590009475	salt bridge; other site
435590009476	sequence-specific DNA binding site [nucleotide binding]; other site
435590009477	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
435590009478	Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404
435590009479	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
435590009480	putative active site [active]
435590009481	putative metal binding site [ion binding]; other site
435590009482	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
435590009483	putative active site [active]
435590009484	putative metal binding site [ion binding]; other site
435590009485	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
435590009486	non-specific DNA binding site [nucleotide binding]; other site
435590009487	salt bridge; other site
435590009488	sequence-specific DNA binding site [nucleotide binding]; other site
435590009489	Protein of unknown function (DUF3791); Region: DUF3791; pfam12668
435590009490	Transposase domain (DUF772); Region: DUF772; cl15789
435590009491	Transposase domain (DUF772); Region: DUF772; cl15789
435590009492	Helix-turn-helix domains; Region: HTH; cl00088
435590009493	Winged helix-turn helix; Region: HTH_29; pfam13551
435590009494	Integrase core domain; Region: rve; cl01316
435590009495	transcription elongation factor NusA-like protein; Validated; Region: PRK08406
435590009496	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
435590009497	Formaldehyde dehydrogenases; Region: FDH_like; cd05278
435590009498	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
435590009499	catalytic Zn binding site [ion binding]; other site
435590009500	NAD(P) binding site [chemical binding]; other site
435590009501	structural Zn binding site [ion binding]; other site
435590009502	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
435590009503	putative dimer interface [polypeptide binding]; other site
435590009504	GtrA-like protein; Region: GtrA; cl00971
435590009505	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590009506	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
435590009507	NAD(P) binding site [chemical binding]; other site
435590009508	active site
435590009509	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
435590009510	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
435590009511	putative metal binding site [ion binding]; other site
435590009512	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
435590009513	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
435590009514	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
435590009515	putative active site [active]
435590009516	putative catalytic site [active]
435590009517	Nitrous oxide-stimulated promoter; Region: YgbA_NO; cl08119
435590009518	Low molecular weight phosphatase family; Region: LMWPc; cl00105
435590009519	active site
435590009520	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
435590009521	active site
435590009522	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
435590009523	MatE; Region: MatE; cl10513
435590009524	MatE; Region: MatE; cl10513
435590009525	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
435590009526	Cation transport protein; Region: TrkH; cl10514
435590009527	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
435590009528	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
435590009529	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
435590009530	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
435590009531	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
435590009532	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
435590009533	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590009534	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
435590009535	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
435590009536	dimer interface [polypeptide binding]; other site
435590009537	PYR/PP interface [polypeptide binding]; other site
435590009538	TPP binding site [chemical binding]; other site
435590009539	substrate binding site [chemical binding]; other site
435590009540	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
435590009541	Domain of unknown function; Region: EKR; cl11037
435590009542	4Fe-4S binding domain; Region: Fer4; cl02805
435590009543	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
435590009544	TPP-binding site [chemical binding]; other site
435590009545	dimer interface [polypeptide binding]; other site
435590009546	Sulfatase; Region: Sulfatase; cl10460
435590009547	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
435590009548	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
435590009549	Transposase domain (DUF772); Region: DUF772; cl15789
435590009550	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
435590009551	Transposase domain (DUF772); Region: DUF772; cl15789
435590009552	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
435590009553	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590009554	active site
435590009555	phosphorylation site [posttranslational modification]
435590009556	intermolecular recognition site; other site
435590009557	dimerization interface [polypeptide binding]; other site
435590009558	LytTr DNA-binding domain; Region: LytTR; cl04498
435590009559	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590009560	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590009561	binding surface
435590009562	TPR motif; other site
435590009563	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590009564	Histidine kinase; Region: His_kinase; pfam06580
435590009565	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
435590009566	Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017
435590009567	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
435590009568	active site
435590009569	catalytic residues [active]
435590009570	EamA-like transporter family; Region: EamA; cl01037
435590009571	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
435590009572	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
435590009573	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
435590009574	active site
435590009575	substrate binding site [chemical binding]; other site
435590009576	metal binding site [ion binding]; metal-binding site
435590009577	Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690
435590009578	Peptidase family C69; Region: Peptidase_C69; pfam03577
435590009579	Peptidase family M23; Region: Peptidase_M23; pfam01551
435590009580	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
435590009581	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379
435590009582	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590009583	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
435590009584	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
435590009585	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
435590009586	Helix-turn-helix domains; Region: HTH; cl00088
435590009587	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
435590009588	putative dimerization interface [polypeptide binding]; other site
435590009589	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
435590009590	Clp amino terminal domain; Region: Clp_N; pfam02861
435590009591	Clp amino terminal domain; Region: Clp_N; pfam02861
435590009592	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590009593	Walker A motif; other site
435590009594	ATP binding site [chemical binding]; other site
435590009595	Walker B motif; other site
435590009596	arginine finger; other site
435590009597	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590009598	Walker A motif; other site
435590009599	ATP binding site [chemical binding]; other site
435590009600	Walker B motif; other site
435590009601	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
435590009602	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
435590009603	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
435590009604	CoA-binding site [chemical binding]; other site
435590009605	ATP-binding [chemical binding]; other site
435590009606	YbbR-like protein; Region: YbbR; pfam07949
435590009607	Preprotein translocase subunit; Region: YajC; cl00806
435590009608	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
435590009609	Protein of unknown function (DUF3276); Region: DUF3276; cl15305
435590009610	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
435590009611	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
435590009612	5S rRNA interface [nucleotide binding]; other site
435590009613	CTC domain interface [polypeptide binding]; other site
435590009614	L16 interface [polypeptide binding]; other site
435590009615	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
435590009616	putative active site [active]
435590009617	catalytic residue [active]
435590009618	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
435590009619	RNA binding surface [nucleotide binding]; other site
435590009620	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
435590009621	nucleotide binding site/active site [active]
435590009622	HIT family signature motif; other site
435590009623	catalytic residue [active]
435590009624	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
435590009625	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
435590009626	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
435590009627	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
435590009628	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
435590009629	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
435590009630	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
435590009631	peptidase T; Region: peptidase-T; TIGR01882
435590009632	metal binding site [ion binding]; metal-binding site
435590009633	dimer interface [polypeptide binding]; other site
435590009634	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
435590009635	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
435590009636	active site
435590009637	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
435590009638	active site
435590009639	CrcB-like protein; Region: CRCB; cl09114
435590009640	NigD-like protein; Region: NigD; pfam12667
435590009641	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590009642	Two component regulator propeller; Region: Reg_prop; pfam07494
435590009643	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
435590009644	Y_Y_Y domain; Region: Y_Y_Y; pfam07495
435590009645	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590009646	dimer interface [polypeptide binding]; other site
435590009647	phosphorylation site [posttranslational modification]
435590009648	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590009649	ATP binding site [chemical binding]; other site
435590009650	Mg2+ binding site [ion binding]; other site
435590009651	G-X-G motif; other site
435590009652	Response regulator receiver domain; Region: Response_reg; pfam00072
435590009653	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590009654	active site
435590009655	phosphorylation site [posttranslational modification]
435590009656	intermolecular recognition site; other site
435590009657	dimerization interface [polypeptide binding]; other site
435590009658	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
435590009659	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590009660	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
435590009661	active site
435590009662	Domain of unknown function (DUF303); Region: DUF303; pfam03629
435590009663	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
435590009664	Domain of unknown function (DUF303); Region: DUF303; pfam03629
435590009665	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
435590009666	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
435590009667	beta-D-glucuronidase; Provisional; Region: PRK10150
435590009668	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590009669	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
435590009670	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
435590009671	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
435590009672	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
435590009673	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
435590009674	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
435590009675	putative active site [active]
435590009676	putative substrate binding site [chemical binding]; other site
435590009677	putative cosubstrate binding site; other site
435590009678	catalytic site [active]
435590009679	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181
435590009680	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
435590009681	putative active site [active]
435590009682	oxyanion strand; other site
435590009683	catalytic triad [active]
435590009684	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
435590009685	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
435590009686	catalytic residues [active]
435590009687	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
435590009688	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
435590009689	substrate binding site [chemical binding]; other site
435590009690	glutamase interaction surface [polypeptide binding]; other site
435590009691	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
435590009692	Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344
435590009693	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
435590009694	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
435590009695	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590009696	Walker A/P-loop; other site
435590009697	ATP binding site [chemical binding]; other site
435590009698	Q-loop/lid; other site
435590009699	ABC transporter signature motif; other site
435590009700	Walker B; other site
435590009701	D-loop; other site
435590009702	H-loop/switch region; other site
435590009703	aspartate kinase III; Validated; Region: PRK09084
435590009704	AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243
435590009705	putative catalytic residues [active]
435590009706	nucleotide binding site [chemical binding]; other site
435590009707	aspartate binding site [chemical binding]; other site
435590009708	ACT domains located C-terminal to the catalytic domain of  the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912
435590009709	dimer interface [polypeptide binding]; other site
435590009710	allosteric regulatory binding pocket; other site
435590009711	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
435590009712	dimer interface [polypeptide binding]; other site
435590009713	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
435590009714	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
435590009715	active site
435590009716	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
435590009717	substrate binding site [chemical binding]; other site
435590009718	catalytic residues [active]
435590009719	dimer interface [polypeptide binding]; other site
435590009720	Transposase domain (DUF772); Region: DUF772; cl15789
435590009721	Transposase domain (DUF772); Region: DUF772; cl15789
435590009722	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
435590009723	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
435590009724	active site
435590009725	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
435590009726	Membrane protein of unknown function (DUF340); Region: DUF340; cl01028
435590009727	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
435590009728	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
435590009729	FtsX-like permease family; Region: FtsX; cl15850
435590009730	aspartate aminotransferase; Provisional; Region: PRK07568
435590009731	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
435590009732	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590009733	homodimer interface [polypeptide binding]; other site
435590009734	catalytic residue [active]
435590009735	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
435590009736	substrate binding site [chemical binding]; other site
435590009737	trimer interface [polypeptide binding]; other site
435590009738	hexamer (dimer of trimers) interface [polypeptide binding]; other site
435590009739	Mn binding site [ion binding]; other site
435590009740	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
435590009741	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
435590009742	catalytic residue [active]
435590009743	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
435590009744	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
435590009745	phosphate binding site [ion binding]; other site
435590009746	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
435590009747	AMP-binding enzyme; Region: AMP-binding; cl15778
435590009748	Domain of unknown function (DUF3943); Region: DUF3943; pfam13084
435590009749	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
435590009750	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
435590009751	ligand binding site [chemical binding]; other site
435590009752	flexible hinge region; other site
435590009753	Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690
435590009754	Peptidase family C69; Region: Peptidase_C69; pfam03577
435590009755	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298
435590009756	active site
435590009757	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
435590009758	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
435590009759	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
435590009760	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
435590009761	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
435590009762	Aspartase; Region: Aspartase; cd01357
435590009763	active sites [active]
435590009764	tetramer interface [polypeptide binding]; other site
435590009765	Uncharacterized conserved protein [Function unknown]; Region: COG1284
435590009766	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
435590009767	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
435590009768	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498
435590009769	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
435590009770	UDP-glucose 4-epimerase; Region: PLN02240
435590009771	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
435590009772	NAD binding site [chemical binding]; other site
435590009773	homodimer interface [polypeptide binding]; other site
435590009774	active site
435590009775	substrate binding site [chemical binding]; other site
435590009776	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
435590009777	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
435590009778	FMN-binding domain; Region: FMN_bind; cl01081
435590009779	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
435590009780	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
435590009781	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
435590009782	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
435590009783	SLBB domain; Region: SLBB; pfam10531
435590009784	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
435590009785	ferredoxin; Validated; Region: PRK07118
435590009786	Putative Fe-S cluster; Region: FeS; pfam04060
435590009787	4Fe-4S binding domain; Region: Fer4; cl02805
435590009788	4Fe-4S binding domain; Region: Fer4; cl02805
435590009789	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178
435590009790	threonine dehydratase; Provisional; Region: PRK08198
435590009791	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
435590009792	tetramer interface [polypeptide binding]; other site
435590009793	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590009794	catalytic residue [active]
435590009795	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
435590009796	EamA-like transporter family; Region: EamA; cl01037
435590009797	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
435590009798	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590009799	putative substrate translocation pore; other site
435590009800	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
435590009801	tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812
435590009802	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590009803	catalytic residue [active]
435590009804	Glutaminase; Region: Glutaminase; cl00907
435590009805	CutC family; Region: CutC; cl01218
435590009806	Transposase domain (DUF772); Region: DUF772; cl15789
435590009807	Transposase domain (DUF772); Region: DUF772; cl15789
435590009808	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
435590009809	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
435590009810	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
435590009811	Ion channel; Region: Ion_trans_2; cl11596
435590009812	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
435590009813	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590009814	dimer interface [polypeptide binding]; other site
435590009815	phosphorylation site [posttranslational modification]
435590009816	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590009817	ATP binding site [chemical binding]; other site
435590009818	Mg2+ binding site [ion binding]; other site
435590009819	G-X-G motif; other site
435590009820	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
435590009821	GTP-binding protein LepA; Provisional; Region: PRK05433
435590009822	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
435590009823	G1 box; other site
435590009824	putative GEF interaction site [polypeptide binding]; other site
435590009825	GTP/Mg2+ binding site [chemical binding]; other site
435590009826	Switch I region; other site
435590009827	G2 box; other site
435590009828	G3 box; other site
435590009829	Switch II region; other site
435590009830	G4 box; other site
435590009831	G5 box; other site
435590009832	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
435590009833	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
435590009834	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
435590009835	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
435590009836	Predicted ATPase [General function prediction only]; Region: COG4637
435590009837	ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules.  The...; Region: ABC_ATPase; cd00267
435590009838	ABC transporter signature motif; other site
435590009839	Walker B; other site
435590009840	D-loop; other site
435590009841	H-loop/switch region; other site
435590009842	Protein of unknown function (DUF2582); Region: DUF2582; pfam10771
435590009843	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920
435590009844	2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410
435590009845	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590009846	recombination factor protein RarA; Reviewed; Region: PRK13342
435590009847	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
435590009848	Walker A motif; other site
435590009849	ATP binding site [chemical binding]; other site
435590009850	Walker B motif; other site
435590009851	arginine finger; other site
435590009852	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
435590009853	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
435590009854	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
435590009855	amidase catalytic site [active]
435590009856	Zn binding residues [ion binding]; other site
435590009857	substrate binding site [chemical binding]; other site
435590009858	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
435590009859	active site
435590009860	metal binding site [ion binding]; metal-binding site
435590009861	interdomain interaction site; other site
435590009862	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590009863	AAA domain; Region: AAA_25; pfam13481
435590009864	Walker A motif; other site
435590009865	ATP binding site [chemical binding]; other site
435590009866	Walker B motif; other site
435590009867	Domain of unknown function (DUF4373); Region: DUF4373; pfam14297
435590009868	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
435590009869	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
435590009870	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
435590009871	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590009872	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
435590009873	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
435590009874	active site
435590009875	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
435590009876	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
435590009877	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
435590009878	metal-binding site
435590009879	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
435590009880	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590009881	MatE; Region: MatE; cl10513
435590009882	Transcription antiterminator [Transcription]; Region: NusG; COG0250
435590009883	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766
435590009884	Protein of unknown function DUF86; Region: DUF86; cl01031
435590009885	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
435590009886	active site
435590009887	NTP binding site [chemical binding]; other site
435590009888	metal binding triad [ion binding]; metal-binding site
435590009889	antibiotic binding site [chemical binding]; other site
435590009890	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590009891	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
435590009892	PhoU domain; Region: PhoU; pfam01895
435590009893	PhoU domain; Region: PhoU; pfam01895
435590009894	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14245
435590009895	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
435590009896	Walker A/P-loop; other site
435590009897	ATP binding site [chemical binding]; other site
435590009898	Q-loop/lid; other site
435590009899	ABC transporter signature motif; other site
435590009900	Walker B; other site
435590009901	D-loop; other site
435590009902	H-loop/switch region; other site
435590009903	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
435590009904	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
435590009905	dimer interface [polypeptide binding]; other site
435590009906	conserved gate region; other site
435590009907	putative PBP binding loops; other site
435590009908	ABC-ATPase subunit interface; other site
435590009909	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
435590009910	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
435590009911	dimer interface [polypeptide binding]; other site
435590009912	conserved gate region; other site
435590009913	putative PBP binding loops; other site
435590009914	ABC-ATPase subunit interface; other site
435590009915	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
435590009916	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
435590009917	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
435590009918	active site
435590009919	HIGH motif; other site
435590009920	nucleotide binding site [chemical binding]; other site
435590009921	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
435590009922	active site
435590009923	KMSKS motif; other site
435590009924	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
435590009925	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
435590009926	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590009927	binding surface
435590009928	TPR motif; other site
435590009929	Tetratricopeptide repeat; Region: TPR_12; pfam13424
435590009930	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
435590009931	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
435590009932	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
435590009933	dimer interface [polypeptide binding]; other site
435590009934	catalytic triad [active]
435590009935	peroxidatic and resolving cysteines [active]
435590009936	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
435590009937	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
435590009938	NADP binding site [chemical binding]; other site
435590009939	active site
435590009940	putative substrate binding site [chemical binding]; other site
435590009941	GDP-mannose 4,6-dehydratase; Region: gmd; TIGR01472
435590009942	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
435590009943	NADP-binding site; other site
435590009944	homotetramer interface [polypeptide binding]; other site
435590009945	substrate binding site [chemical binding]; other site
435590009946	homodimer interface [polypeptide binding]; other site
435590009947	active site
435590009948	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
435590009949	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
435590009950	Substrate binding site; other site
435590009951	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
435590009952	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590009953	Bacterial sugar transferase; Region: Bac_transf; cl00939
435590009954	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
435590009955	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
435590009956	substrate binding site; other site
435590009957	tetramer interface; other site
435590009958	Cupin domain; Region: Cupin_2; cl09118
435590009959	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
435590009960	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
435590009961	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
435590009962	SLBB domain; Region: SLBB; pfam10531
435590009963	SLBB domain; Region: SLBB; pfam10531
435590009964	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
435590009965	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
435590009966	SLBB domain; Region: SLBB; pfam10531
435590009967	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
435590009968	SLBB domain; Region: SLBB; pfam10531
435590009969	L-rhamnose isomerase (RhaA); Region: RhaA; cl09945
435590009970	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
435590009971	D-xylulose kinases, subgroup 2; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_2; cd07810
435590009972	putative N- and C-terminal domain interface [polypeptide binding]; other site
435590009973	putative active site [active]
435590009974	catalytic site [active]
435590009975	metal binding site [ion binding]; metal-binding site
435590009976	putative xylulose binding site [chemical binding]; other site
435590009977	putative ATP binding site [chemical binding]; other site
435590009978	putative homodimer interface [polypeptide binding]; other site
435590009979	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
435590009980	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
435590009981	Response regulator receiver domain; Region: Response_reg; pfam00072
435590009982	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590009983	active site
435590009984	phosphorylation site [posttranslational modification]
435590009985	intermolecular recognition site; other site
435590009986	dimerization interface [polypeptide binding]; other site
435590009987	Bacterial sugar transferase; Region: Bac_transf; cl00939
435590009988	Bacterial sugar transferase; Region: Bac_transf; cl00939
435590009989	Outer membrane efflux protein; Region: OEP; pfam02321
435590009990	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
435590009991	O-Antigen ligase; Region: Wzy_C; cl04850
435590009992	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
435590009993	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
435590009994	Probable Catalytic site; other site
435590009995	metal-binding site
435590009996	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
435590009997	DXD motif; other site
435590009998	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
435590009999	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
435590010000	DXD motif; other site
435590010001	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
435590010002	trimer interface [polypeptide binding]; other site
435590010003	active site
435590010004	substrate binding site [chemical binding]; other site
435590010005	CoA binding site [chemical binding]; other site
435590010006	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
435590010007	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
435590010008	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
435590010009	active site
435590010010	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
435590010011	metal-binding site
435590010012	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
435590010013	ABC_KpsT_Wzt   The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export.  Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220
435590010014	Walker A/P-loop; other site
435590010015	ATP binding site [chemical binding]; other site
435590010016	Q-loop/lid; other site
435590010017	ABC transporter signature motif; other site
435590010018	Walker B; other site
435590010019	D-loop; other site
435590010020	H-loop/switch region; other site
435590010021	ABC-2 type transporter; Region: ABC2_membrane; cl11417
435590010022	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590010023	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
435590010024	putative ADP-binding pocket [chemical binding]; other site
435590010025	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
435590010026	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
435590010027	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
435590010028	active site
435590010029	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
435590010030	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590010031	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
435590010032	putative ADP-binding pocket [chemical binding]; other site
435590010033	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
435590010034	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590010035	putative ADP-binding pocket [chemical binding]; other site
435590010036	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
435590010037	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590010038	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
435590010039	putative ADP-binding pocket [chemical binding]; other site
435590010040	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
435590010041	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590010042	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
435590010043	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
435590010044	active site
435590010045	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590010046	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
435590010047	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
435590010048	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
435590010049	Response regulator receiver domain; Region: Response_reg; pfam00072
435590010050	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590010051	active site
435590010052	phosphorylation site [posttranslational modification]
435590010053	intermolecular recognition site; other site
435590010054	dimerization interface [polypeptide binding]; other site
435590010055	PAS fold; Region: PAS; pfam00989
435590010056	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590010057	dimer interface [polypeptide binding]; other site
435590010058	phosphorylation site [posttranslational modification]
435590010059	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590010060	ATP binding site [chemical binding]; other site
435590010061	Mg2+ binding site [ion binding]; other site
435590010062	G-X-G motif; other site
435590010063	Response regulator receiver domain; Region: Response_reg; pfam00072
435590010064	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590010065	active site
435590010066	phosphorylation site [posttranslational modification]
435590010067	intermolecular recognition site; other site
435590010068	dimerization interface [polypeptide binding]; other site
435590010069	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084
435590010070	putative catalytic site [active]
435590010071	putative metal binding site [ion binding]; other site
435590010072	putative phosphate binding site [ion binding]; other site
435590010073	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590010074	active site
435590010075	phosphorylation site [posttranslational modification]
435590010076	intermolecular recognition site; other site
435590010077	dimerization interface [polypeptide binding]; other site
435590010078	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590010079	dimer interface [polypeptide binding]; other site
435590010080	phosphorylation site [posttranslational modification]
435590010081	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590010082	ATP binding site [chemical binding]; other site
435590010083	Mg2+ binding site [ion binding]; other site
435590010084	G-X-G motif; other site
435590010085	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
435590010086	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
435590010087	NAD binding site [chemical binding]; other site
435590010088	putative substrate binding site 2 [chemical binding]; other site
435590010089	putative substrate binding site 1 [chemical binding]; other site
435590010090	active site
435590010091	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
435590010092	dimer interface [polypeptide binding]; other site
435590010093	substrate binding site [chemical binding]; other site
435590010094	ATP binding site [chemical binding]; other site
435590010095	Acyl transferase domain; Region: Acyl_transf_1; cl08282
435590010096	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
435590010097	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
435590010098	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
435590010099	active site
435590010100	nucleophile elbow; other site
435590010101	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_3; cd11349
435590010102	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
435590010103	active site
435590010104	catalytic site [active]
435590010105	HpaII restriction endonuclease; Region: RE_HpaII; pfam09561
435590010106	Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile.  CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902
435590010107	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
435590010108	Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: AlaS; COG0013
435590010109	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
435590010110	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
435590010111	putative dimer interface [polypeptide binding]; other site
435590010112	PAS fold; Region: PAS_4; pfam08448
435590010113	PAS domain; Region: PAS_9; pfam13426
435590010114	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
435590010115	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590010116	dimer interface [polypeptide binding]; other site
435590010117	phosphorylation site [posttranslational modification]
435590010118	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590010119	ATP binding site [chemical binding]; other site
435590010120	Mg2+ binding site [ion binding]; other site
435590010121	G-X-G motif; other site
435590010122	Response regulator receiver domain; Region: Response_reg; pfam00072
435590010123	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590010124	active site
435590010125	phosphorylation site [posttranslational modification]
435590010126	intermolecular recognition site; other site
435590010127	dimerization interface [polypeptide binding]; other site
435590010128	carbamoyl-phosphate synthase, large subunit; Region: CPSaseII_lrg; TIGR01369
435590010129	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
435590010130	ATP-grasp domain; Region: ATP-grasp_4; cl03087
435590010131	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
435590010132	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
435590010133	ATP-grasp domain; Region: ATP-grasp_4; cl03087
435590010134	Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain; Region: MGS_CPS_I_III; cd01423
435590010135	probable substrate binding site [chemical binding]; other site
435590010136	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
435590010137	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056
435590010138	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
435590010139	catalytic site [active]
435590010140	subunit interface [polypeptide binding]; other site
435590010141	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
435590010142	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
435590010143	active site
435590010144	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
435590010145	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
435590010146	glutaminase active site [active]
435590010147	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
435590010148	dimer interface [polypeptide binding]; other site
435590010149	active site
435590010150	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
435590010151	dimer interface [polypeptide binding]; other site
435590010152	active site
435590010153	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
435590010154	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
435590010155	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
435590010156	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
435590010157	Nitrogen regulatory protein P-II; Region: P-II; cl00412
435590010158	Nitrogen regulatory protein P-II; Region: P-II; smart00938
435590010159	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
435590010160	LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542
435590010161	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
435590010162	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590010163	homodimer interface [polypeptide binding]; other site
435590010164	catalytic residue [active]
435590010165	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
435590010166	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
435590010167	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
435590010168	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
435590010169	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
435590010170	active site
435590010171	dimer interface [polypeptide binding]; other site
435590010172	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
435590010173	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
435590010174	active site
435590010175	FMN binding site [chemical binding]; other site
435590010176	substrate binding site [chemical binding]; other site
435590010177	3Fe-4S cluster binding site [ion binding]; other site
435590010178	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
435590010179	domain interface; other site
435590010180	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
435590010181	asparagine synthetase B; Provisional; Region: asnB; PRK09431
435590010182	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
435590010183	active site
435590010184	dimer interface [polypeptide binding]; other site
435590010185	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
435590010186	Ligand Binding Site [chemical binding]; other site
435590010187	Molecular Tunnel; other site
435590010188	Transposase domain (DUF772); Region: DUF772; cl15789
435590010189	Transposase domain (DUF772); Region: DUF772; cl15789
435590010190	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590010191	ATP binding site [chemical binding]; other site
435590010192	putative Mg++ binding site [ion binding]; other site
435590010193	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
435590010194	nucleotide binding region [chemical binding]; other site
435590010195	ATP-binding site [chemical binding]; other site
435590010196	HEPN domain; Region: HEPN; cl00824
435590010197	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
435590010198	active site
435590010199	NTP binding site [chemical binding]; other site
435590010200	metal binding triad [ion binding]; metal-binding site
435590010201	antibiotic binding site [chemical binding]; other site
435590010202	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
435590010203	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
435590010204	extended (e) SDRs; Region: SDR_e; cd08946
435590010205	NAD(P) binding site [chemical binding]; other site
435590010206	active site
435590010207	substrate binding site [chemical binding]; other site
435590010208	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
435590010209	putative ADP-binding pocket [chemical binding]; other site
435590010210	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
435590010211	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
435590010212	Integrase core domain; Region: rve; cl01316
435590010213	chromosome segregation protein; Provisional; Region: PRK02224
435590010214	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891
435590010215	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
435590010216	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
435590010217	active site
435590010218	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
435590010219	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
435590010220	inhibitor-cofactor binding pocket; inhibition site
435590010221	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590010222	catalytic residue [active]
435590010223	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
435590010224	substrate binding site; other site
435590010225	Cupin domain; Region: Cupin_2; cl09118
435590010226	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
435590010227	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590010228	NAD(P) binding site [chemical binding]; other site
435590010229	active site
435590010230	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
435590010231	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
435590010232	catalytic residue [active]
435590010233	MatE; Region: MatE; cl10513
435590010234	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
435590010235	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
435590010236	active site
435590010237	4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944
435590010238	active site
435590010239	catalytic residues [active]
435590010240	metal binding site [ion binding]; metal-binding site
435590010241	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
435590010242	Ligand binding site; other site
435590010243	oligomer interface; other site
435590010244	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
435590010245	NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426
435590010246	Substrate binding site; other site
435590010247	metal-binding site
435590010248	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
435590010249	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
435590010250	NeuB family; Region: NeuB; cl00496
435590010251	SAF domain; Region: SAF; cl00555
435590010252	carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767
435590010253	ATP-grasp domain; Region: ATP-grasp_4; cl03087
435590010254	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme MccE; Region: PLPDE_III_MccE_like; cd06841
435590010255	diaminopimelate decarboxylase; Region: lysA; TIGR01048
435590010256	dimer interface [polypeptide binding]; other site
435590010257	active site
435590010258	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
435590010259	catalytic residues [active]
435590010260	substrate binding site [chemical binding]; other site
435590010261	UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568
435590010262	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
435590010263	active site
435590010264	homodimer interface [polypeptide binding]; other site
435590010265	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
435590010266	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
435590010267	inhibitor-cofactor binding pocket; inhibition site
435590010268	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590010269	catalytic residue [active]
435590010270	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590010271	NAD(P) binding site [chemical binding]; other site
435590010272	active site
435590010273	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
435590010274	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
435590010275	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
435590010276	amidase catalytic site [active]
435590010277	Zn binding residues [ion binding]; other site
435590010278	substrate binding site [chemical binding]; other site
435590010279	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620
435590010280	putative ligand binding site [chemical binding]; other site
435590010281	Uncharacterized BCR, COG1649; Region: DUF187; cl15398
435590010282	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
435590010283	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
435590010284	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
435590010285	active site
435590010286	substrate binding site [chemical binding]; other site
435590010287	Mg2+ binding site [ion binding]; other site
435590010288	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
435590010289	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412
435590010290	YceG-like family; Region: YceG; pfam02618
435590010291	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
435590010292	dimerization interface [polypeptide binding]; other site
435590010293	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
435590010294	4Fe-4S binding domain; Region: Fer4; cl02805
435590010295	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
435590010296	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
435590010297	23S rRNA binding site [nucleotide binding]; other site
435590010298	L21 binding site [polypeptide binding]; other site
435590010299	L13 binding site [polypeptide binding]; other site
435590010300	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
435590010301	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
435590010302	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
435590010303	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
435590010304	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
435590010305	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
435590010306	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
435590010307	active site
435590010308	dimer interface [polypeptide binding]; other site
435590010309	motif 1; other site
435590010310	motif 2; other site
435590010311	motif 3; other site
435590010312	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
435590010313	anticodon binding site; other site
435590010314	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590010315	TPR motif; other site
435590010316	binding surface
435590010317	TPR repeat; Region: TPR_11; pfam13414
435590010318	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590010319	binding surface
435590010320	TPR repeat; Region: TPR_11; pfam13414
435590010321	TPR motif; other site
435590010322	TPR repeat; Region: TPR_11; pfam13414
435590010323	TPR repeat; Region: TPR_11; pfam13414
435590010324	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590010325	binding surface
435590010326	TPR motif; other site
435590010327	Tetratricopeptide repeat; Region: TPR_16; pfam13432
435590010328	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
435590010329	binding surface
435590010330	TPR motif; other site
435590010331	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
435590010332	active site
435590010333	catalytic residues [active]
435590010334	metal binding site [ion binding]; metal-binding site
435590010335	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
435590010336	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
435590010337	Domain of unknown function (DUF3869); Region: DUF3869; pfam12985
435590010338	Domain of unknown function (DUF3870); Region: DUF3870; pfam12986
435590010339	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl01155
435590010340	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
435590010341	ligand binding site [chemical binding]; other site
435590010342	Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201
435590010343	Sporulation related domain; Region: SPOR; cl10051
435590010344	Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946
435590010345	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
435590010346	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
435590010347	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
435590010348	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
435590010349	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
435590010350	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
435590010351	protein binding site [polypeptide binding]; other site
435590010352	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
435590010353	Domain interface; other site
435590010354	Peptide binding site; other site
435590010355	Active site tetrad [active]
435590010356	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
435590010357	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590010358	putative substrate translocation pore; other site
435590010359	Sulfatase; Region: Sulfatase; cl10460
435590010360	Surface antigen; Region: Bac_surface_Ag; cl03097
435590010361	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
435590010362	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
435590010363	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
435590010364	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
435590010365	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
435590010366	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
435590010367	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590010368	Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842
435590010369	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
435590010370	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
435590010371	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
435590010372	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
435590010373	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
435590010374	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590010375	catalytic residue [active]
435590010376	anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
435590010377	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
435590010378	chorismate binding enzyme; Region: Chorismate_bind; cl10555
435590010379	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
435590010380	Glutamine amidotransferase class-I; Region: GATase; pfam00117
435590010381	glutamine binding [chemical binding]; other site
435590010382	catalytic triad [active]
435590010383	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
435590010384	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
435590010385	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
435590010386	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
435590010387	active site
435590010388	ribulose/triose binding site [chemical binding]; other site
435590010389	phosphate binding site [ion binding]; other site
435590010390	substrate (anthranilate) binding pocket [chemical binding]; other site
435590010391	product (indole) binding pocket [chemical binding]; other site
435590010392	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405
435590010393	active site
435590010394	tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111
435590010395	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
435590010396	substrate binding site [chemical binding]; other site
435590010397	active site
435590010398	catalytic residues [active]
435590010399	heterodimer interface [polypeptide binding]; other site
435590010400	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
435590010401	active site
435590010402	homodimer interface [polypeptide binding]; other site
435590010403	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
435590010404	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
435590010405	active site
435590010406	phosphorylation site [posttranslational modification]
435590010407	intermolecular recognition site; other site
435590010408	dimerization interface [polypeptide binding]; other site
435590010409	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
435590010410	DNA binding site [nucleotide binding]
435590010411	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
435590010412	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
435590010413	dimer interface [polypeptide binding]; other site
435590010414	phosphorylation site [posttranslational modification]
435590010415	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
435590010416	ATP binding site [chemical binding]; other site
435590010417	Mg2+ binding site [ion binding]; other site
435590010418	G-X-G motif; other site
435590010419	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
435590010420	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
435590010421	gliding motility-associated protein GldE; Region: GldE; TIGR03520
435590010422	Domain of unknown function DUF21; Region: DUF21; pfam01595
435590010423	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
435590010424	Transporter associated domain; Region: CorC_HlyC; cl08393
435590010425	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
435590010426	dimer interface [polypeptide binding]; other site
435590010427	ssDNA binding site [nucleotide binding]; other site
435590010428	tetramer (dimer of dimers) interface [polypeptide binding]; other site
435590010429	A/G-specific adenine glycosylase; Region: mutY; TIGR01084
435590010430	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
435590010431	minor groove reading motif; other site
435590010432	helix-hairpin-helix signature motif; other site
435590010433	substrate binding pocket [chemical binding]; other site
435590010434	active site
435590010435	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
435590010436	DNA binding and oxoG recognition site [nucleotide binding]
435590010437	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
435590010438	IHF - DNA interface [nucleotide binding]; other site
435590010439	IHF dimer interface [polypeptide binding]; other site
435590010440	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
435590010441	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
435590010442	homodimer interface [polypeptide binding]; other site
435590010443	oligonucleotide binding site [chemical binding]; other site
435590010444	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
435590010445	active site
435590010446	metal binding site [ion binding]; metal-binding site
435590010447	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
435590010448	catalytic residues [active]
435590010449	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
435590010450	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
435590010451	dimer interface [polypeptide binding]; other site
435590010452	putative anticodon binding site; other site
435590010453	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
435590010454	motif 1; other site
435590010455	active site
435590010456	motif 2; other site
435590010457	motif 3; other site
435590010458	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
435590010459	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590010460	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
435590010461	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
435590010462	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
435590010463	active site
435590010464	dimer interface [polypeptide binding]; other site
435590010465	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
435590010466	dimer interface [polypeptide binding]; other site
435590010467	active site
435590010468	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
435590010469	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
435590010470	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
435590010471	motif II; other site
435590010472	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
435590010473	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590010474	Secretin and TonB N terminus short domain; Region: STN; cl06624
435590010475	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590010476	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590010477	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590010478	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590010479	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
435590010480	FecR protein; Region: FecR; pfam04773
435590010481	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
435590010482	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
435590010483	DNA binding residues [nucleotide binding]
435590010484	Helix-turn-helix domains; Region: HTH; cl00088
435590010485	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
435590010486	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
435590010487	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
435590010488	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
435590010489	catalytic residue [active]
435590010490	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
435590010491	N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942
435590010492	dimerization interface [polypeptide binding]; other site
435590010493	putative active cleft [active]
435590010494	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
435590010495	putative substrate translocation pore; other site
435590010496	Major Facilitator Superfamily; Region: MFS_1; pfam07690
435590010497	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
435590010498	active site
435590010499	trimer interface [polypeptide binding]; other site
435590010500	allosteric site; other site
435590010501	active site lid [active]
435590010502	hexamer (dimer of trimers) interface [polypeptide binding]; other site
435590010503	glucosamine-6-phosphate deaminase-like protein; Validated; Region: PRK02122
435590010504	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
435590010505	active site
435590010506	trimer interface [polypeptide binding]; other site
435590010507	allosteric site; other site
435590010508	active site lid [active]
435590010509	hexamer (dimer of trimers) interface [polypeptide binding]; other site
435590010510	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
435590010511	Protein of unknown function (DUF2400); Region: DUF2400; cl09884
435590010512	Helix-turn-helix domain; Region: HTH_18; pfam12833
435590010513	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
435590010514	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
435590010515	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
435590010516	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
435590010517	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
435590010518	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
435590010519	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
435590010520	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
435590010521	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
435590010522	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
435590010523	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
435590010524	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
435590010525	Walker A/P-loop; other site
435590010526	ATP binding site [chemical binding]; other site
435590010527	Q-loop/lid; other site
435590010528	ABC transporter signature motif; other site
435590010529	Walker B; other site
435590010530	D-loop; other site
435590010531	H-loop/switch region; other site
435590010532	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
435590010533	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
435590010534	active site
435590010535	dimer interface [polypeptide binding]; other site
435590010536	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
435590010537	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590010538	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
435590010539	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590010540	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
435590010541	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; cl15460
435590010542	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
435590010543	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
435590010544	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
435590010545	active site
435590010546	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
435590010547	cyclically-permuted mutatrotase family protein; Region: mutarot_permut; TIGR03548
435590010548	Kelch motif; Region: Kelch_1; cl02701
435590010549	Kelch motif; Region: Kelch_1; cl02701
435590010550	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
435590010551	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
435590010552	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
435590010553	active site
435590010554	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
435590010555	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
435590010556	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
435590010557	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
435590010558	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
435590010559	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
435590010560	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
435590010561	active site
435590010562	catalytic triad [active]
435590010563	oxyanion hole [active]
435590010564	Domain of unknown function (DUF303); Region: DUF303; pfam03629
435590010565	sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828
435590010566	active site
435590010567	catalytic triad [active]
435590010568	oxyanion hole [active]
435590010569	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
435590010570	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
435590010571	active site
435590010572	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
435590010573	catalytic site [active]
435590010574	Asp-box motif; other site
435590010575	starch binding outer membrane protein SusD; Region: SusD; cd08977
435590010576	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
435590010577	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590010578	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
435590010579	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590010580	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
435590010581	dimer interface [polypeptide binding]; other site
435590010582	active site
435590010583	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
435590010584	ligand binding site [chemical binding]; other site
435590010585	active site
435590010586	UGI interface [polypeptide binding]; other site
435590010587	catalytic site [active]
435590010588	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
435590010589	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
435590010590	Zn2+ binding site [ion binding]; other site
435590010591	Mg2+ binding site [ion binding]; other site
435590010592	Protein of unknown function (DUF1343); Region: DUF1343; cl01598
435590010593	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
435590010594	Catalytic site [active]
435590010595	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
435590010596	active site
435590010597	metal-binding site [ion binding]
435590010598	nucleotide-binding site [chemical binding]; other site
435590010599	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
435590010600	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
435590010601	Walker A/P-loop; other site
435590010602	ATP binding site [chemical binding]; other site
435590010603	Q-loop/lid; other site
435590010604	ABC transporter signature motif; other site
435590010605	Walker B; other site
435590010606	D-loop; other site
435590010607	H-loop/switch region; other site
435590010608	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
435590010609	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
435590010610	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
435590010611	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
435590010612	VanD integrase, IntD, and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases including those similar to IntD, a putative integrase-like protein, a component...; Region: INT_VanD; cd01196
435590010613	Int/Topo IB signature motif; other site
435590010614	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
435590010615	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
435590010616	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
435590010617	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
435590010618	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
435590010619	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
435590010620	HsdM N-terminal domain; Region: HsdM_N; pfam12161
435590010621	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
435590010622	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
435590010623	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
435590010624	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
435590010625	ATP binding site [chemical binding]; other site
435590010626	putative Mg++ binding site [ion binding]; other site
435590010627	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
435590010628	non-specific DNA binding site [nucleotide binding]; other site
435590010629	salt bridge; other site
435590010630	sequence-specific DNA binding site [nucleotide binding]; other site
435590010631	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447
435590010632	GIY-YIG motif/motif A; other site
435590010633	putative active site [active]
435590010634	putative metal binding site [ion binding]; other site
435590010635	Domain of unknown function (DUF4357); Region: DUF4357; pfam14267
435590010636	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
435590010637	Protein of unknown function DUF262; Region: DUF262; cl14890
435590010638	Protein of unknown function DUF262; Region: DUF262; cl14890
435590010639	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
435590010640	Putative esterase; Region: Esterase; pfam00756
435590010641	maltose O-acetyltransferase; Provisional; Region: PRK10092
435590010642	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
435590010643	active site
435590010644	substrate binding site [chemical binding]; other site
435590010645	trimer interface [polypeptide binding]; other site
435590010646	CoA binding site [chemical binding]; other site
435590010647	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
435590010648	Protein of unknown function (DUF3737); Region: DUF3737; pfam12541
435590010649	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
435590010650	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
435590010651	pyridoxal 5'-phosphate binding site [chemical binding]; other site
435590010652	homodimer interface [polypeptide binding]; other site
435590010653	catalytic residue [active]
435590010654	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
435590010655	dimerization interface [polypeptide binding]; other site
435590010656	putative DNA binding site [nucleotide binding]; other site
435590010657	putative Zn2+ binding site [ion binding]; other site
435590010658	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
435590010659	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
435590010660	Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953
435590010661	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
435590010662	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
435590010663	P loop; other site
435590010664	Nucleotide binding site [chemical binding]; other site
435590010665	DTAP/Switch II; other site
435590010666	Switch I; other site
435590010667	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
435590010668	P loop; other site
435590010669	Nucleotide binding site [chemical binding]; other site
435590010670	DTAP/Switch II; other site
435590010671	Switch I; other site
435590010672	Low molecular weight phosphatase family; Region: LMWPc; cd00115
435590010673	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
435590010674	active site
435590010675	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
435590010676	Membrane transport protein; Region: Mem_trans; cl09117
435590010677	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
435590010678	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
435590010679	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl00284
435590010680	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
435590010681	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
435590010682	active site
435590010683	metal binding site [ion binding]; metal-binding site
435590010684	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
435590010685	mce related protein; Region: MCE; pfam02470