-- dump date 20120504_134730 -- class Genbank::misc_feature -- table misc_feature_note -- id note 471853000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 471853000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471853000003 Walker A motif; other site 471853000004 ATP binding site [chemical binding]; other site 471853000005 Walker B motif; other site 471853000006 arginine finger; other site 471853000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 471853000008 DnaA box-binding interface [nucleotide binding]; other site 471853000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 471853000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 471853000011 putative DNA binding surface [nucleotide binding]; other site 471853000012 dimer interface [polypeptide binding]; other site 471853000013 beta-clamp/clamp loader binding surface; other site 471853000014 beta-clamp/translesion DNA polymerase binding surface; other site 471853000015 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853000016 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 471853000017 recombination protein F; Reviewed; Region: recF; PRK00064 471853000018 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 471853000019 Walker A/P-loop; other site 471853000020 ATP binding site [chemical binding]; other site 471853000021 Q-loop/lid; other site 471853000022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853000023 ABC transporter signature motif; other site 471853000024 Walker B; other site 471853000025 D-loop; other site 471853000026 H-loop/switch region; other site 471853000027 Protein of unknown function (DUF721); Region: DUF721; cl02324 471853000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 471853000029 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 471853000030 anchoring element; other site 471853000031 dimer interface [polypeptide binding]; other site 471853000032 ATP binding site [chemical binding]; other site 471853000033 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 471853000034 active site 471853000035 putative metal-binding site [ion binding]; other site 471853000036 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 471853000037 DNA gyrase subunit A; Validated; Region: PRK05560 471853000038 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 471853000039 CAP-like domain; other site 471853000040 active site 471853000041 primary dimer interface [polypeptide binding]; other site 471853000042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471853000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471853000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471853000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471853000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471853000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471853000048 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 471853000049 YCII-related domain; Region: YCII; cl00999 471853000050 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853000051 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471853000052 active site 471853000053 metal binding site [ion binding]; metal-binding site 471853000054 Cupin domain; Region: Cupin_2; cl09118 471853000055 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853000056 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853000057 DNA binding site [nucleotide binding] 471853000058 domain linker motif; other site 471853000059 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853000060 dimerization interface [polypeptide binding]; other site 471853000061 ligand binding site [chemical binding]; other site 471853000062 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853000063 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853000064 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853000065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000066 putative PBP binding loops; other site 471853000067 dimer interface [polypeptide binding]; other site 471853000068 ABC-ATPase subunit interface; other site 471853000069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000070 dimer interface [polypeptide binding]; other site 471853000071 conserved gate region; other site 471853000072 putative PBP binding loops; other site 471853000073 ABC-ATPase subunit interface; other site 471853000074 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 471853000075 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 471853000076 active site 471853000077 Rhomboid family; Region: Rhomboid; cl11446 471853000078 Uncharacterized protein family (UPF0233); Region: UPF0233; cl11506 471853000079 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 471853000080 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 471853000081 active site 471853000082 catalytic site [active] 471853000083 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 471853000084 Glutamine amidotransferase class-I; Region: GATase; pfam00117 471853000085 glutamine binding [chemical binding]; other site 471853000086 catalytic triad [active] 471853000087 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471853000088 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471853000089 active site 471853000090 ATP binding site [chemical binding]; other site 471853000091 substrate binding site [chemical binding]; other site 471853000092 activation loop (A-loop); other site 471853000093 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471853000094 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471853000095 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471853000096 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471853000097 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471853000098 active site 471853000099 ATP binding site [chemical binding]; other site 471853000100 substrate binding site [chemical binding]; other site 471853000101 activation loop (A-loop); other site 471853000102 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 471853000103 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 471853000104 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 471853000105 active site 471853000106 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471853000107 phosphopeptide binding site; other site 471853000108 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 471853000109 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471853000110 phosphopeptide binding site; other site 471853000111 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471853000112 salt bridge; other site 471853000113 non-specific DNA binding site [nucleotide binding]; other site 471853000114 sequence-specific DNA binding site [nucleotide binding]; other site 471853000115 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 471853000116 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 471853000117 active site 471853000118 catalytic site [active] 471853000119 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 471853000120 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853000121 ligand binding site [chemical binding]; other site 471853000122 dimerization interface [polypeptide binding]; other site 471853000123 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 471853000124 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 471853000125 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 471853000126 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 471853000127 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471853000128 substrate binding site [chemical binding]; other site 471853000129 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471853000130 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000131 dimer interface [polypeptide binding]; other site 471853000132 conserved gate region; other site 471853000133 putative PBP binding loops; other site 471853000134 ABC-ATPase subunit interface; other site 471853000135 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 471853000136 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000137 dimer interface [polypeptide binding]; other site 471853000138 conserved gate region; other site 471853000139 putative PBP binding loops; other site 471853000140 ABC-ATPase subunit interface; other site 471853000141 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 471853000142 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471853000143 Walker A/P-loop; other site 471853000144 ATP binding site [chemical binding]; other site 471853000145 Q-loop/lid; other site 471853000146 ABC transporter signature motif; other site 471853000147 Walker B; other site 471853000148 D-loop; other site 471853000149 H-loop/switch region; other site 471853000150 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853000151 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 471853000152 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471853000153 Walker A/P-loop; other site 471853000154 ATP binding site [chemical binding]; other site 471853000155 Q-loop/lid; other site 471853000156 ABC transporter signature motif; other site 471853000157 Walker B; other site 471853000158 D-loop; other site 471853000159 H-loop/switch region; other site 471853000160 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853000161 Helix-turn-helix domains; Region: HTH; cl00088 471853000162 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471853000163 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471853000164 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 471853000165 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853000166 DNA-binding site [nucleotide binding]; DNA binding site 471853000167 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471853000168 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853000169 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853000170 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 471853000171 active site 471853000172 catalytic tetrad [active] 471853000173 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 471853000174 FMN binding site [chemical binding]; other site 471853000175 dimer interface [polypeptide binding]; other site 471853000176 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 471853000177 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853000178 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 471853000179 dimer interface [polypeptide binding]; other site 471853000180 catalytic triad [active] 471853000181 cyanate transporter; Region: CynX; TIGR00896 471853000182 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 471853000183 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 471853000184 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 471853000185 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 471853000186 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853000187 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853000188 DNA binding site [nucleotide binding] 471853000189 domain linker motif; other site 471853000190 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853000191 dimerization interface [polypeptide binding]; other site 471853000192 ligand binding site [chemical binding]; other site 471853000193 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853000194 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853000195 DNA binding site [nucleotide binding] 471853000196 domain linker motif; other site 471853000197 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853000198 ligand binding site [chemical binding]; other site 471853000199 dimerization interface [polypeptide binding]; other site 471853000200 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 471853000201 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 471853000202 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853000203 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853000204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000205 dimer interface [polypeptide binding]; other site 471853000206 conserved gate region; other site 471853000207 putative PBP binding loops; other site 471853000208 ABC-ATPase subunit interface; other site 471853000209 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853000210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853000211 Protein of unknown function, DUF624; Region: DUF624; cl02369 471853000212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 471853000213 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 471853000214 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853000215 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 471853000216 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 471853000217 Cupin domain; Region: Cupin_2; cl09118 471853000218 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 471853000219 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853000220 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 471853000221 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 471853000222 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 471853000223 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 471853000224 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471853000225 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 471853000226 active site 471853000227 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471853000228 FAD binding domain; Region: FAD_binding_4; pfam01565 471853000229 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471853000230 Berberine and berberine like; Region: BBE; pfam08031 471853000231 Cupin domain; Region: Cupin_2; cl09118 471853000232 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 471853000233 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 471853000234 YCII-related domain; Region: YCII; cl00999 471853000235 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471853000236 catalytic core [active] 471853000237 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 471853000238 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 471853000239 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 471853000240 active site 471853000241 substrate binding site [chemical binding]; other site 471853000242 ATP binding site [chemical binding]; other site 471853000243 Helix-turn-helix domains; Region: HTH; cl00088 471853000244 Helix-turn-helix domains; Region: HTH; cl00088 471853000245 dimerization interface [polypeptide binding]; other site 471853000246 DNA binding residues [nucleotide binding] 471853000247 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 471853000248 active site 471853000249 catalytic residues [active] 471853000250 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 471853000251 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 471853000252 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853000253 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471853000254 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 471853000255 YceI-like domain; Region: YceI; cl01001 471853000256 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853000257 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471853000258 active site 471853000259 catalytic tetrad [active] 471853000260 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 471853000261 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 471853000262 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471853000263 catalytic residue [active] 471853000264 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 471853000265 homotrimer interaction site [polypeptide binding]; other site 471853000266 putative active site [active] 471853000267 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 471853000268 catalytic residues [active] 471853000269 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 471853000270 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 471853000271 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 471853000272 Class I ribonucleotide reductase; Region: RNR_I; cd01679 471853000273 active site 471853000274 dimer interface [polypeptide binding]; other site 471853000275 catalytic residues [active] 471853000276 effector binding site; other site 471853000277 R2 peptide binding site; other site 471853000278 GIY-YIG domain of uncharacterized hypothetical protein found in phycodnavirus PBCV-1 DNA virus, T. thermophila Tlr element eoncoding protein Tlr8p, and similar proteins found in bacteria; Region: GIY-YIG_HE_Tlr8p_PBC-V_like; cd10443 471853000279 GIY-YIG motif/motif A; other site 471853000280 putative active site [active] 471853000281 putative metal binding site [ion binding]; other site 471853000282 GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cl14912 471853000283 GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cl14912 471853000284 DNA binding site [nucleotide binding] 471853000285 DNA binding site [nucleotide binding] 471853000286 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 471853000287 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 471853000288 dimer interface [polypeptide binding]; other site 471853000289 putative radical transfer pathway; other site 471853000290 diiron center [ion binding]; other site 471853000291 tyrosyl radical; other site 471853000292 Short C-terminal domain; Region: SHOCT; cl01373 471853000293 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853000294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853000295 active site 471853000296 phosphorylation site [posttranslational modification] 471853000297 intermolecular recognition site; other site 471853000298 dimerization interface [polypeptide binding]; other site 471853000299 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853000300 DNA binding residues [nucleotide binding] 471853000301 dimerization interface [polypeptide binding]; other site 471853000302 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471853000303 Histidine kinase; Region: HisKA_3; pfam07730 471853000304 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471853000305 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 471853000306 active site 471853000307 substrate binding site [chemical binding]; other site 471853000308 ATP binding site [chemical binding]; other site 471853000309 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471853000310 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 471853000311 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853000312 DNA-binding site [nucleotide binding]; DNA binding site 471853000313 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 471853000314 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471853000315 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 471853000316 active site 471853000317 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471853000318 active site 471853000319 ATP binding site [chemical binding]; other site 471853000320 substrate binding site [chemical binding]; other site 471853000321 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 471853000322 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 471853000323 FAD binding pocket [chemical binding]; other site 471853000324 FAD binding motif [chemical binding]; other site 471853000325 phosphate binding motif [ion binding]; other site 471853000326 NAD binding pocket [chemical binding]; other site 471853000327 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 471853000328 NodB motif; other site 471853000329 active site 471853000330 catalytic site [active] 471853000331 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 471853000332 Amidohydrolase; Region: Amidohydro_4; pfam13147 471853000333 active site 471853000334 Low molecular weight phosphatase family; Region: LMWPc; cd00115 471853000335 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 471853000336 active site 471853000337 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 471853000338 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 471853000339 putative dimer interface [polypeptide binding]; other site 471853000340 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853000341 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471853000342 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853000343 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471853000344 active site 471853000345 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 471853000346 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853000347 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 471853000348 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471853000349 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853000350 NAD(P) binding site [chemical binding]; other site 471853000351 active site 471853000352 Transcriptional regulators [Transcription]; Region: FadR; COG2186 471853000353 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853000354 DNA-binding site [nucleotide binding]; DNA binding site 471853000355 FCD domain; Region: FCD; cl11656 471853000356 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 471853000357 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 471853000358 active site pocket [active] 471853000359 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 471853000360 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471853000361 classical (c) SDRs; Region: SDR_c; cd05233 471853000362 NAD(P) binding site [chemical binding]; other site 471853000363 active site 471853000364 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853000365 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 471853000366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000367 dimer interface [polypeptide binding]; other site 471853000368 conserved gate region; other site 471853000369 putative PBP binding loops; other site 471853000370 ABC-ATPase subunit interface; other site 471853000371 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853000372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000373 dimer interface [polypeptide binding]; other site 471853000374 conserved gate region; other site 471853000375 putative PBP binding loops; other site 471853000376 ABC-ATPase subunit interface; other site 471853000377 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 471853000378 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 471853000379 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 471853000380 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471853000381 active site 471853000382 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 471853000383 Protein of unknown function (DUF419); Region: DUF419; cl15265 471853000384 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 471853000385 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; cl15460 471853000386 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853000387 Helix-turn-helix domains; Region: HTH; cl00088 471853000388 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471853000389 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853000390 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853000391 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 471853000392 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; cl09957 471853000393 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 471853000394 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 471853000395 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 471853000396 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 471853000397 Walker A/P-loop; other site 471853000398 ATP binding site [chemical binding]; other site 471853000399 Q-loop/lid; other site 471853000400 ABC transporter signature motif; other site 471853000401 Walker B; other site 471853000402 D-loop; other site 471853000403 H-loop/switch region; other site 471853000404 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 471853000405 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471853000406 ABC-ATPase subunit interface; other site 471853000407 dimer interface [polypeptide binding]; other site 471853000408 putative PBP binding regions; other site 471853000409 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 471853000410 ABC-ATPase subunit interface; other site 471853000411 dimer interface [polypeptide binding]; other site 471853000412 putative PBP binding regions; other site 471853000413 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 471853000414 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 471853000415 intersubunit interface [polypeptide binding]; other site 471853000416 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853000417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000418 dimer interface [polypeptide binding]; other site 471853000419 conserved gate region; other site 471853000420 putative PBP binding loops; other site 471853000421 ABC-ATPase subunit interface; other site 471853000422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000423 dimer interface [polypeptide binding]; other site 471853000424 conserved gate region; other site 471853000425 putative PBP binding loops; other site 471853000426 ABC-ATPase subunit interface; other site 471853000427 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 471853000428 active site 471853000429 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 471853000430 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 471853000431 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 471853000432 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 471853000433 putative active site [active] 471853000434 Predicted transcriptional regulator [Transcription]; Region: COG2378 471853000435 Helix-turn-helix domains; Region: HTH; cl00088 471853000436 WYL domain; Region: WYL; cl14852 471853000437 Epoxide hydrolase N terminus; Region: EHN; pfam06441 471853000438 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853000439 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 471853000440 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 471853000441 methylenetetrahydromethanopterin reductase; Provisional; Region: PRK02271 471853000442 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471853000443 TIGR04076 family protein; Region: TIGR04076 471853000444 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 471853000445 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471853000446 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 471853000447 active site 471853000448 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471853000449 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 471853000450 Walker A/P-loop; other site 471853000451 ATP binding site [chemical binding]; other site 471853000452 Q-loop/lid; other site 471853000453 ABC transporter signature motif; other site 471853000454 Walker B; other site 471853000455 D-loop; other site 471853000456 H-loop/switch region; other site 471853000457 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853000458 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 471853000459 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471853000460 Walker A/P-loop; other site 471853000461 ATP binding site [chemical binding]; other site 471853000462 Q-loop/lid; other site 471853000463 ABC transporter signature motif; other site 471853000464 Walker B; other site 471853000465 D-loop; other site 471853000466 H-loop/switch region; other site 471853000467 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853000468 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 471853000469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000470 dimer interface [polypeptide binding]; other site 471853000471 conserved gate region; other site 471853000472 ABC-ATPase subunit interface; other site 471853000473 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471853000474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000475 dimer interface [polypeptide binding]; other site 471853000476 conserved gate region; other site 471853000477 putative PBP binding loops; other site 471853000478 ABC-ATPase subunit interface; other site 471853000479 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 471853000480 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471853000481 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 471853000482 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471853000483 non-specific DNA binding site [nucleotide binding]; other site 471853000484 salt bridge; other site 471853000485 sequence-specific DNA binding site [nucleotide binding]; other site 471853000486 Cupin domain; Region: Cupin_2; cl09118 471853000487 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471853000488 active site 471853000489 metal binding site [ion binding]; metal-binding site 471853000490 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853000491 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471853000492 active site 471853000493 catalytic tetrad [active] 471853000494 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 471853000495 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 471853000496 active site 471853000497 catalytic triad [active] 471853000498 oxyanion hole [active] 471853000499 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cl03513 471853000500 substrate binding site [chemical binding]; other site 471853000501 catalytic residues [active] 471853000502 Helix-turn-helix domains; Region: HTH; cl00088 471853000503 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471853000504 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471853000505 Sulfatase; Region: Sulfatase; cl10460 471853000506 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471853000507 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853000508 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853000509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000510 dimer interface [polypeptide binding]; other site 471853000511 conserved gate region; other site 471853000512 ABC-ATPase subunit interface; other site 471853000513 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853000514 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000515 dimer interface [polypeptide binding]; other site 471853000516 conserved gate region; other site 471853000517 putative PBP binding loops; other site 471853000518 ABC-ATPase subunit interface; other site 471853000519 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 471853000520 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 471853000521 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 471853000522 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 471853000523 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 471853000524 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471853000525 FAD binding domain; Region: FAD_binding_4; pfam01565 471853000526 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 471853000527 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 471853000528 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471853000529 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853000530 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853000531 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853000532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000533 dimer interface [polypeptide binding]; other site 471853000534 conserved gate region; other site 471853000535 putative PBP binding loops; other site 471853000536 ABC-ATPase subunit interface; other site 471853000537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853000538 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853000539 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853000540 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853000541 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853000542 DNA binding site [nucleotide binding] 471853000543 domain linker motif; other site 471853000544 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 471853000545 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 471853000546 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 471853000547 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 471853000548 Dehydratase family; Region: ILVD_EDD; cl00340 471853000549 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853000550 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 471853000551 NAD(P) binding site [chemical binding]; other site 471853000552 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 471853000553 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 471853000554 Protein of unknown function (DUF998); Region: DUF998; pfam06197 471853000555 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 471853000556 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853000557 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 471853000558 Helix-turn-helix domains; Region: HTH; cl00088 471853000559 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853000560 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471853000561 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471853000562 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 471853000563 Epoxide hydrolase N terminus; Region: EHN; pfam06441 471853000564 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853000565 Predicted transcriptional regulator [Transcription]; Region: COG2378 471853000566 Helix-turn-helix domains; Region: HTH; cl00088 471853000567 WYL domain; Region: WYL; cl14852 471853000568 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 471853000569 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 471853000570 intersubunit interface [polypeptide binding]; other site 471853000571 active site 471853000572 catalytic residue [active] 471853000573 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 471853000574 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471853000575 NAD(P) binding site [chemical binding]; other site 471853000576 catalytic residues [active] 471853000577 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 471853000578 SprT homologues; Region: SprT; cl01182 471853000579 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 471853000580 active site 471853000581 catalytic residues [active] 471853000582 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471853000583 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471853000584 DNA binding residues [nucleotide binding] 471853000585 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 471853000586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853000587 S-adenosylmethionine binding site [chemical binding]; other site 471853000588 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 471853000589 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 471853000590 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 471853000591 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 471853000592 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471853000593 Domain of unknown function DUF20; Region: UPF0118; pfam01594 471853000594 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 471853000595 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853000596 Coenzyme A binding pocket [chemical binding]; other site 471853000597 Helix-turn-helix domains; Region: HTH; cl00088 471853000598 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 471853000599 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471853000600 dimerization interface [polypeptide binding]; other site 471853000601 cyclase homology domain; Region: CHD; cd07302 471853000602 nucleotidyl binding site; other site 471853000603 metal binding site [ion binding]; metal-binding site 471853000604 dimer interface [polypeptide binding]; other site 471853000605 Mechanosensitive ion channel; Region: MS_channel; pfam00924 471853000606 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471853000607 ligand binding site [chemical binding]; other site 471853000608 flexible hinge region; other site 471853000609 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 471853000610 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471853000611 ATP binding site [chemical binding]; other site 471853000612 putative Mg++ binding site [ion binding]; other site 471853000613 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471853000614 nucleotide binding region [chemical binding]; other site 471853000615 ATP-binding site [chemical binding]; other site 471853000616 Helicase associated domain (HA2); Region: HA2; cl04503 471853000617 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 471853000618 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 471853000619 hypothetical protein; Provisional; Region: PRK06753 471853000620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853000621 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853000622 S-adenosylmethionine binding site [chemical binding]; other site 471853000623 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 471853000624 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 471853000625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853000626 putative substrate translocation pore; other site 471853000627 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853000628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853000629 active site 471853000630 phosphorylation site [posttranslational modification] 471853000631 intermolecular recognition site; other site 471853000632 dimerization interface [polypeptide binding]; other site 471853000633 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853000634 DNA binding residues [nucleotide binding] 471853000635 dimerization interface [polypeptide binding]; other site 471853000636 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853000637 Coenzyme A binding pocket [chemical binding]; other site 471853000638 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 471853000639 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 471853000640 FAD binding site [chemical binding]; other site 471853000641 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 471853000642 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 471853000643 THF binding site; other site 471853000644 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 471853000645 substrate binding site [chemical binding]; other site 471853000646 THF binding site; other site 471853000647 zinc-binding site [ion binding]; other site 471853000648 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 471853000649 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471853000650 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 471853000651 iron-sulfur cluster [ion binding]; other site 471853000652 [2Fe-2S] cluster binding site [ion binding]; other site 471853000653 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 471853000654 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 471853000655 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853000656 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471853000657 DNA binding residues [nucleotide binding] 471853000658 Putative zinc-finger; Region: zf-HC2; cl15806 471853000659 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 471853000660 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 471853000661 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 471853000662 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853000663 Family description; Region: UvrD_C_2; cl15862 471853000664 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853000665 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853000666 AAA domain; Region: AAA_18; pfam13238 471853000667 active site 471853000668 amino acid transporter; Region: 2A0306; TIGR00909 471853000669 Spore germination protein; Region: Spore_permease; cl15802 471853000670 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 471853000671 diiron binding motif [ion binding]; other site 471853000672 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 471853000673 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 471853000674 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 471853000675 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853000676 Walker A/P-loop; other site 471853000677 ATP binding site [chemical binding]; other site 471853000678 Q-loop/lid; other site 471853000679 ABC transporter signature motif; other site 471853000680 Walker B; other site 471853000681 D-loop; other site 471853000682 H-loop/switch region; other site 471853000683 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 471853000684 Helix-turn-helix domains; Region: HTH; cl00088 471853000685 enterobactin exporter EntS; Provisional; Region: PRK10489 471853000686 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853000687 putative substrate translocation pore; other site 471853000688 Cupin domain; Region: Cupin_2; cl09118 471853000689 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471853000690 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853000691 NAD(P) binding site [chemical binding]; other site 471853000692 active site 471853000693 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 471853000694 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853000695 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471853000696 DNA binding residues [nucleotide binding] 471853000697 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 471853000698 Helix-turn-helix domains; Region: HTH; cl00088 471853000699 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 471853000700 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853000701 Coenzyme A binding pocket [chemical binding]; other site 471853000702 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 471853000703 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 471853000704 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 471853000705 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 471853000706 active site 471853000707 DNA binding site [nucleotide binding] 471853000708 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 471853000709 DNA binding site [nucleotide binding] 471853000710 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 471853000711 hydrophobic ligand binding site; other site 471853000712 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 471853000713 Permease family; Region: Xan_ur_permease; pfam00860 471853000714 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 471853000715 active site 471853000716 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853000717 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853000718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000719 dimer interface [polypeptide binding]; other site 471853000720 putative PBP binding loops; other site 471853000721 ABC-ATPase subunit interface; other site 471853000722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000723 dimer interface [polypeptide binding]; other site 471853000724 conserved gate region; other site 471853000725 putative PBP binding loops; other site 471853000726 ABC-ATPase subunit interface; other site 471853000727 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 471853000728 substrate binding site [chemical binding]; other site 471853000729 dimer interface [polypeptide binding]; other site 471853000730 ATP binding site [chemical binding]; other site 471853000731 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853000732 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853000733 DNA binding site [nucleotide binding] 471853000734 domain linker motif; other site 471853000735 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853000736 ligand binding site [chemical binding]; other site 471853000737 dimerization interface [polypeptide binding]; other site 471853000738 Cupin domain; Region: Cupin_2; cl09118 471853000739 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471853000740 Helix-turn-helix domains; Region: HTH; cl00088 471853000741 WHG domain; Region: WHG; pfam13305 471853000742 Uncharacterized conserved protein [Function unknown]; Region: COG2128 471853000743 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 471853000744 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 471853000745 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853000746 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 471853000747 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853000748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853000749 active site 471853000750 phosphorylation site [posttranslational modification] 471853000751 intermolecular recognition site; other site 471853000752 dimerization interface [polypeptide binding]; other site 471853000753 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853000754 DNA binding residues [nucleotide binding] 471853000755 dimerization interface [polypeptide binding]; other site 471853000756 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471853000757 Histidine kinase; Region: HisKA_3; pfam07730 471853000758 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471853000759 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471853000760 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853000761 Walker A/P-loop; other site 471853000762 ATP binding site [chemical binding]; other site 471853000763 Q-loop/lid; other site 471853000764 ABC transporter signature motif; other site 471853000765 Walker B; other site 471853000766 D-loop; other site 471853000767 H-loop/switch region; other site 471853000768 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 471853000769 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 471853000770 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 471853000771 active site 471853000772 dimer interface [polypeptide binding]; other site 471853000773 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 471853000774 dimer interface [polypeptide binding]; other site 471853000775 active site 471853000776 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471853000777 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 471853000778 substrate binding pocket [chemical binding]; other site 471853000779 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471853000780 Histidine kinase; Region: HisKA_3; pfam07730 471853000781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471853000782 ATP binding site [chemical binding]; other site 471853000783 Mg2+ binding site [ion binding]; other site 471853000784 G-X-G motif; other site 471853000785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853000786 active site 471853000787 phosphorylation site [posttranslational modification] 471853000788 intermolecular recognition site; other site 471853000789 dimerization interface [polypeptide binding]; other site 471853000790 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853000791 dimerization interface [polypeptide binding]; other site 471853000792 DNA binding residues [nucleotide binding] 471853000793 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 471853000794 Short C-terminal domain; Region: SHOCT; cl01373 471853000795 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471853000796 anti sigma factor interaction site; other site 471853000797 regulatory phosphorylation site [posttranslational modification]; other site 471853000798 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 471853000799 Helix-turn-helix domains; Region: HTH; cl00088 471853000800 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 471853000801 Helix-turn-helix domains; Region: HTH; cl00088 471853000802 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853000803 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 471853000804 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971 471853000805 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089 471853000806 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972 471853000807 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471853000808 Sulfatase; Region: Sulfatase; cl10460 471853000809 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853000810 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853000811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853000812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000813 conserved gate region; other site 471853000814 dimer interface [polypeptide binding]; other site 471853000815 putative PBP binding loops; other site 471853000816 ABC-ATPase subunit interface; other site 471853000817 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853000818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000819 dimer interface [polypeptide binding]; other site 471853000820 conserved gate region; other site 471853000821 putative PBP binding loops; other site 471853000822 ABC-ATPase subunit interface; other site 471853000823 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853000824 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853000825 DNA binding site [nucleotide binding] 471853000826 domain linker motif; other site 471853000827 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853000828 ligand binding site [chemical binding]; other site 471853000829 dimerization interface [polypeptide binding]; other site 471853000830 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853000831 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853000832 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 471853000833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000834 dimer interface [polypeptide binding]; other site 471853000835 conserved gate region; other site 471853000836 putative PBP binding loops; other site 471853000837 ABC-ATPase subunit interface; other site 471853000838 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 471853000839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000840 dimer interface [polypeptide binding]; other site 471853000841 conserved gate region; other site 471853000842 putative PBP binding loops; other site 471853000843 ABC-ATPase subunit interface; other site 471853000844 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 471853000845 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 471853000846 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 471853000847 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471853000848 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853000849 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853000850 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853000851 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 471853000852 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 471853000853 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 471853000854 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 471853000855 putative active site [active] 471853000856 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853000857 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000858 dimer interface [polypeptide binding]; other site 471853000859 conserved gate region; other site 471853000860 putative PBP binding loops; other site 471853000861 ABC-ATPase subunit interface; other site 471853000862 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 471853000863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000864 dimer interface [polypeptide binding]; other site 471853000865 conserved gate region; other site 471853000866 putative PBP binding loops; other site 471853000867 ABC-ATPase subunit interface; other site 471853000868 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853000869 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853000870 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 471853000871 CGNR zinc finger; Region: zf-CGNR; pfam11706 471853000872 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 471853000873 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 471853000874 catalytic residues [active] 471853000875 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471853000876 active site 471853000877 substrate binding site [chemical binding]; other site 471853000878 ATP binding site [chemical binding]; other site 471853000879 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 471853000880 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 471853000881 tetramer interface [polypeptide binding]; other site 471853000882 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853000883 catalytic residue [active] 471853000884 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 471853000885 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 471853000886 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 471853000887 DinB superfamily; Region: DinB_2; pfam12867 471853000888 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853000889 TIGR03086 family protein; Region: TIGR03086 471853000890 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853000891 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853000892 active site 471853000893 phosphorylation site [posttranslational modification] 471853000894 intermolecular recognition site; other site 471853000895 dimerization interface [polypeptide binding]; other site 471853000896 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853000897 DNA binding residues [nucleotide binding] 471853000898 dimerization interface [polypeptide binding]; other site 471853000899 Histidine kinase; Region: HisKA_3; pfam07730 471853000900 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471853000901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853000902 Response regulator receiver domain; Region: Response_reg; pfam00072 471853000903 active site 471853000904 phosphorylation site [posttranslational modification] 471853000905 intermolecular recognition site; other site 471853000906 dimerization interface [polypeptide binding]; other site 471853000907 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 471853000908 PAS domain S-box; Region: sensory_box; TIGR00229 471853000909 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471853000910 dimer interface [polypeptide binding]; other site 471853000911 phosphorylation site [posttranslational modification] 471853000912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471853000913 ATP binding site [chemical binding]; other site 471853000914 Mg2+ binding site [ion binding]; other site 471853000915 G-X-G motif; other site 471853000916 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 471853000917 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 471853000918 DXD motif; other site 471853000919 ATP-grasp domain; Region: ATP-grasp_4; cl03087 471853000920 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 471853000921 putative hydrophobic ligand binding site [chemical binding]; other site 471853000922 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853000923 putative DNA binding site [nucleotide binding]; other site 471853000924 putative Zn2+ binding site [ion binding]; other site 471853000925 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 471853000926 glutamate dehydrogenase; Provisional; Region: PRK09414 471853000927 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 471853000928 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853000929 NAD(P) binding pocket [chemical binding]; other site 471853000930 Domain of unknown function (DUF222); Region: DUF222; pfam02720 471853000931 Domain of unknown function (DUF222); Region: DUF222; pfam02720 471853000932 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 471853000933 active site 471853000934 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853000935 Coenzyme A binding pocket [chemical binding]; other site 471853000936 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853000937 putative Zn2+ binding site [ion binding]; other site 471853000938 putative DNA binding site [nucleotide binding]; other site 471853000939 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 471853000940 putative hydrophobic ligand binding site [chemical binding]; other site 471853000941 Helix-turn-helix domains; Region: HTH; cl00088 471853000942 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471853000943 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 471853000944 Walker A/P-loop; other site 471853000945 ATP binding site [chemical binding]; other site 471853000946 Q-loop/lid; other site 471853000947 ABC transporter signature motif; other site 471853000948 Walker B; other site 471853000949 D-loop; other site 471853000950 H-loop/switch region; other site 471853000951 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471853000952 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853000953 DNA binding residues [nucleotide binding] 471853000954 dimerization interface [polypeptide binding]; other site 471853000955 Lamin Tail Domain; Region: LTD; pfam00932 471853000956 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 471853000957 generic binding surface I; other site 471853000958 generic binding surface II; other site 471853000959 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 471853000960 putative active site [active] 471853000961 putative catalytic site [active] 471853000962 putative Mg binding site IVb [ion binding]; other site 471853000963 putative phosphate binding site [ion binding]; other site 471853000964 putative DNA binding site [nucleotide binding]; other site 471853000965 putative Mg binding site IVa [ion binding]; other site 471853000966 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 471853000967 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471853000968 active site 471853000969 metal binding site [ion binding]; metal-binding site 471853000970 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 471853000971 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 471853000972 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 471853000973 ATP-binding site [chemical binding]; other site 471853000974 Gluconate-6-phosphate binding site [chemical binding]; other site 471853000975 pyruvate dehydrogenase; Provisional; Region: PRK06546 471853000976 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 471853000977 PYR/PP interface [polypeptide binding]; other site 471853000978 tetramer interface [polypeptide binding]; other site 471853000979 dimer interface [polypeptide binding]; other site 471853000980 TPP binding site [chemical binding]; other site 471853000981 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 471853000982 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 471853000983 TPP-binding site [chemical binding]; other site 471853000984 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471853000985 catalytic residues [active] 471853000986 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 471853000987 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471853000988 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 471853000989 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 471853000990 putative active site [active] 471853000991 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853000992 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471853000993 putative substrate translocation pore; other site 471853000994 phosphoglucomutase; Validated; Region: PRK07564 471853000995 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 471853000996 active site 471853000997 substrate binding site [chemical binding]; other site 471853000998 metal binding site [ion binding]; metal-binding site 471853000999 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471853001000 active site 471853001001 prephenate dehydratase; Provisional; Region: PRK11898 471853001002 Prephenate dehydratase; Region: PDT; pfam00800 471853001003 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 471853001004 putative L-Phe binding site [chemical binding]; other site 471853001005 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 471853001006 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 471853001007 seryl-tRNA synthetase; Provisional; Region: PRK05431 471853001008 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 471853001009 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 471853001010 dimer interface [polypeptide binding]; other site 471853001011 active site 471853001012 motif 1; other site 471853001013 motif 2; other site 471853001014 motif 3; other site 471853001015 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 471853001016 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853001017 active site 471853001018 motif I; other site 471853001019 motif II; other site 471853001020 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 471853001021 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471853001022 binding surface 471853001023 TPR motif; other site 471853001024 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 471853001025 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 471853001026 YCII-related domain; Region: YCII; cl00999 471853001027 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 471853001028 cyclase homology domain; Region: CHD; cd07302 471853001029 nucleotidyl binding site; other site 471853001030 metal binding site [ion binding]; metal-binding site 471853001031 dimer interface [polypeptide binding]; other site 471853001032 Predicted ATPase [General function prediction only]; Region: COG3899 471853001033 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853001034 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471853001035 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471853001036 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 471853001037 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 471853001038 dimerization interface [polypeptide binding]; other site 471853001039 putative active cleft [active] 471853001040 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 471853001041 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 471853001042 Sulfatase; Region: Sulfatase; cl10460 471853001043 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 471853001044 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853001045 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 471853001046 Walker A/P-loop; other site 471853001047 ATP binding site [chemical binding]; other site 471853001048 Q-loop/lid; other site 471853001049 ABC transporter signature motif; other site 471853001050 Walker B; other site 471853001051 D-loop; other site 471853001052 H-loop/switch region; other site 471853001053 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 471853001054 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471853001055 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 471853001056 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853001057 Predicted ATPase [General function prediction only]; Region: COG3903 471853001058 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471853001059 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 471853001060 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853001061 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 471853001062 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 471853001063 NAD(P) binding site [chemical binding]; other site 471853001064 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 471853001065 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853001066 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471853001067 active site 471853001068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853001069 putative substrate translocation pore; other site 471853001070 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853001071 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853001072 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 471853001073 NAD(P) binding site [chemical binding]; other site 471853001074 active site 471853001075 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853001076 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853001077 active site 471853001078 phosphorylation site [posttranslational modification] 471853001079 intermolecular recognition site; other site 471853001080 dimerization interface [polypeptide binding]; other site 471853001081 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853001082 DNA binding residues [nucleotide binding] 471853001083 dimerization interface [polypeptide binding]; other site 471853001084 Histidine kinase; Region: HisKA_3; pfam07730 471853001085 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471853001086 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 471853001087 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853001088 DNA-binding site [nucleotide binding]; DNA binding site 471853001089 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471853001090 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853001091 homodimer interface [polypeptide binding]; other site 471853001092 catalytic residue [active] 471853001093 DoxX; Region: DoxX; cl00976 471853001094 hypothetical protein; Provisional; Region: PRK06184 471853001095 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853001096 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853001097 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 471853001098 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 471853001099 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 471853001100 NMT1-like family; Region: NMT1_2; cl15260 471853001101 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 471853001102 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 471853001103 Walker A/P-loop; other site 471853001104 ATP binding site [chemical binding]; other site 471853001105 Q-loop/lid; other site 471853001106 ABC transporter signature motif; other site 471853001107 Walker B; other site 471853001108 D-loop; other site 471853001109 H-loop/switch region; other site 471853001110 NIL domain; Region: NIL; cl09633 471853001111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853001112 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 471853001113 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 471853001114 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471853001115 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853001116 homodimer interface [polypeptide binding]; other site 471853001117 catalytic residue [active] 471853001118 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853001119 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471853001120 active site 471853001121 catalytic tetrad [active] 471853001122 Helix-turn-helix domains; Region: HTH; cl00088 471853001123 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 471853001124 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853001125 Helix-turn-helix domains; Region: HTH; cl00088 471853001126 CCC1-related family of proteins; Region: CCC1_like; cl00278 471853001127 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 471853001128 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 471853001129 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853001130 DNA-binding site [nucleotide binding]; DNA binding site 471853001131 UTRA domain; Region: UTRA; cl01230 471853001132 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853001133 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 471853001134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853001135 putative PBP binding loops; other site 471853001136 ABC-ATPase subunit interface; other site 471853001137 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853001138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853001139 dimer interface [polypeptide binding]; other site 471853001140 conserved gate region; other site 471853001141 putative PBP binding loops; other site 471853001142 ABC-ATPase subunit interface; other site 471853001143 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 471853001144 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 471853001145 putative active site cavity [active] 471853001146 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471853001147 Protein of unknown function, DUF488; Region: DUF488; cl01246 471853001148 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 471853001149 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471853001150 Walker A/P-loop; other site 471853001151 ATP binding site [chemical binding]; other site 471853001152 Q-loop/lid; other site 471853001153 ABC transporter signature motif; other site 471853001154 Walker B; other site 471853001155 D-loop; other site 471853001156 H-loop/switch region; other site 471853001157 Domain of unknown function DUF87; Region: DUF87; pfam01935 471853001158 AAA-like domain; Region: AAA_10; pfam12846 471853001159 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853001160 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853001161 DNA binding residues [nucleotide binding] 471853001162 dimerization interface [polypeptide binding]; other site 471853001163 Predicted ATPase [General function prediction only]; Region: COG3903 471853001164 Cupin domain; Region: Cupin_2; cl09118 471853001165 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 471853001166 Protein of unknown function (DUF419); Region: DUF419; cl15265 471853001167 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 471853001168 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853001169 Lipase maturation factor; Region: LMF1; pfam06762 471853001170 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 471853001171 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 471853001172 Walker A/P-loop; other site 471853001173 ATP binding site [chemical binding]; other site 471853001174 Q-loop/lid; other site 471853001175 ABC transporter signature motif; other site 471853001176 Walker B; other site 471853001177 D-loop; other site 471853001178 H-loop/switch region; other site 471853001179 NMT1-like family; Region: NMT1_2; cl15260 471853001180 NMT1/THI5 like; Region: NMT1; pfam09084 471853001181 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 471853001182 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853001183 Domain of unknown function DUF77; Region: DUF77; cl00307 471853001184 aminoglycoside resistance protein; Provisional; Region: PRK13746 471853001185 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 471853001186 active site 471853001187 NTP binding site [chemical binding]; other site 471853001188 metal binding triad [ion binding]; metal-binding site 471853001189 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 471853001190 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 471853001191 FtsX-like permease family; Region: FtsX; cl15850 471853001192 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471853001193 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 471853001194 Walker A/P-loop; other site 471853001195 ATP binding site [chemical binding]; other site 471853001196 Q-loop/lid; other site 471853001197 ABC transporter signature motif; other site 471853001198 Walker B; other site 471853001199 D-loop; other site 471853001200 H-loop/switch region; other site 471853001201 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 471853001202 Predicted transcriptional regulator [Transcription]; Region: COG2378 471853001203 WYL domain; Region: WYL; cl14852 471853001204 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 471853001205 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 471853001206 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471853001207 Helix-turn-helix domains; Region: HTH; cl00088 471853001208 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 471853001209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 471853001210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853001211 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 471853001212 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471853001213 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 471853001214 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 471853001215 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471853001216 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471853001217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853001218 dimer interface [polypeptide binding]; other site 471853001219 conserved gate region; other site 471853001220 putative PBP binding loops; other site 471853001221 ABC-ATPase subunit interface; other site 471853001222 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 471853001223 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 471853001224 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471853001225 Walker A/P-loop; other site 471853001226 ATP binding site [chemical binding]; other site 471853001227 Q-loop/lid; other site 471853001228 ABC transporter signature motif; other site 471853001229 Walker B; other site 471853001230 D-loop; other site 471853001231 H-loop/switch region; other site 471853001232 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471853001233 Walker A/P-loop; other site 471853001234 ATP binding site [chemical binding]; other site 471853001235 Q-loop/lid; other site 471853001236 ABC transporter signature motif; other site 471853001237 Walker B; other site 471853001238 D-loop; other site 471853001239 H-loop/switch region; other site 471853001240 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853001241 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 471853001242 putative substrate binding site [chemical binding]; other site 471853001243 active site 471853001244 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 471853001245 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853001246 putative metal binding site [ion binding]; other site 471853001247 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 471853001248 active site 471853001249 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 471853001250 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853001251 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853001252 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 471853001253 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 471853001254 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 471853001255 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 471853001256 active site 471853001257 DNA binding site [nucleotide binding] 471853001258 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 471853001259 DNA binding site [nucleotide binding] 471853001260 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471853001261 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 471853001262 Walker A/P-loop; other site 471853001263 ATP binding site [chemical binding]; other site 471853001264 Q-loop/lid; other site 471853001265 ABC transporter signature motif; other site 471853001266 Walker B; other site 471853001267 D-loop; other site 471853001268 H-loop/switch region; other site 471853001269 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 471853001270 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853001271 Walker A/P-loop; other site 471853001272 ATP binding site [chemical binding]; other site 471853001273 Q-loop/lid; other site 471853001274 ABC transporter signature motif; other site 471853001275 Walker B; other site 471853001276 D-loop; other site 471853001277 H-loop/switch region; other site 471853001278 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853001279 DNA-binding site [nucleotide binding]; DNA binding site 471853001280 Protein of unknown function (DUF328); Region: DUF328; cl01143 471853001281 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 471853001282 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853001283 putative substrate translocation pore; other site 471853001284 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 471853001285 nucleotide binding site [chemical binding]; other site 471853001286 Helix-turn-helix domains; Region: HTH; cl00088 471853001287 Acylphosphatase; Region: Acylphosphatase; cl00551 471853001288 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 471853001289 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471853001290 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 471853001291 CAAX protease self-immunity; Region: Abi; cl00558 471853001292 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 471853001293 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853001294 putative substrate translocation pore; other site 471853001295 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 471853001296 Helix-turn-helix domains; Region: HTH; cl00088 471853001297 Helix-turn-helix domains; Region: HTH; cl00088 471853001298 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 471853001299 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 471853001300 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471853001301 ATP binding site [chemical binding]; other site 471853001302 putative Mg++ binding site [ion binding]; other site 471853001303 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 471853001304 GIY-YIG motif/motif A; other site 471853001305 active site 471853001306 catalytic site [active] 471853001307 metal binding site [ion binding]; metal-binding site 471853001308 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 471853001309 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 471853001310 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 471853001311 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 471853001312 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 471853001313 HsdM N-terminal domain; Region: HsdM_N; pfam12161 471853001314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853001315 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853001316 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 471853001317 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 471853001318 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853001319 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471853001320 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471853001321 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471853001322 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471853001323 catalytic residue [active] 471853001324 Domain of unknown function (DUF1737); Region: DUF1737; cl10503 471853001325 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 471853001326 active site residue [active] 471853001327 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 471853001328 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471853001329 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471853001330 catalytic residue [active] 471853001331 hypothetical protein; Provisional; Region: PRK11770 471853001332 Domain of unknown function (DUF307); Region: DUF307; pfam03733 471853001333 Domain of unknown function (DUF307); Region: DUF307; pfam03733 471853001334 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471853001335 active site 471853001336 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 471853001337 NADP binding site [chemical binding]; other site 471853001338 substrate binding site [chemical binding]; other site 471853001339 active site 471853001340 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853001341 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 471853001342 nucleoside/Zn binding site; other site 471853001343 dimer interface [polypeptide binding]; other site 471853001344 catalytic motif [active] 471853001345 RNA polymerase factor sigma-70; Validated; Region: PRK08241 471853001346 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853001347 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471853001348 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 471853001349 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 471853001350 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 471853001351 Helix-turn-helix domains; Region: HTH; cl00088 471853001352 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 471853001353 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 471853001354 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471853001355 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 471853001356 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 471853001357 Helix-turn-helix domains; Region: HTH; cl00088 471853001358 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 471853001359 putative dimerization interface [polypeptide binding]; other site 471853001360 CrcB-like protein; Region: CRCB; cl09114 471853001361 CrcB-like protein; Region: CRCB; cl09114 471853001362 NAD-dependent deacetylase; Provisional; Region: PRK05333 471853001363 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 471853001364 NAD+ binding site [chemical binding]; other site 471853001365 substrate binding site [chemical binding]; other site 471853001366 Zn binding site [ion binding]; other site 471853001367 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 471853001368 A new structural DNA glycosylase; Region: AlkD_like; cd06561 471853001369 active site 471853001370 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853001371 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 471853001372 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 471853001373 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 471853001374 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 471853001375 FAD binding pocket [chemical binding]; other site 471853001376 FAD binding motif [chemical binding]; other site 471853001377 phosphate binding motif [ion binding]; other site 471853001378 NAD binding pocket [chemical binding]; other site 471853001379 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 471853001380 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471853001381 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471853001382 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471853001383 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471853001384 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 471853001385 Walker A/P-loop; other site 471853001386 ATP binding site [chemical binding]; other site 471853001387 Q-loop/lid; other site 471853001388 ABC transporter signature motif; other site 471853001389 Walker B; other site 471853001390 D-loop; other site 471853001391 H-loop/switch region; other site 471853001392 Helix-turn-helix domains; Region: HTH; cl00088 471853001393 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853001394 dimerization interface [polypeptide binding]; other site 471853001395 putative DNA binding site [nucleotide binding]; other site 471853001396 putative Zn2+ binding site [ion binding]; other site 471853001397 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 471853001398 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471853001399 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 471853001400 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 471853001401 Helix-turn-helix domains; Region: HTH; cl00088 471853001402 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 471853001403 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 471853001404 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 471853001405 metal binding site [ion binding]; metal-binding site 471853001406 putative dimer interface [polypeptide binding]; other site 471853001407 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 471853001408 active site 471853001409 catalytic residues [active] 471853001410 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 471853001411 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 471853001412 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 471853001413 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853001414 Walker A/P-loop; other site 471853001415 ATP binding site [chemical binding]; other site 471853001416 Q-loop/lid; other site 471853001417 ABC transporter signature motif; other site 471853001418 Walker B; other site 471853001419 D-loop; other site 471853001420 H-loop/switch region; other site 471853001421 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 471853001422 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471853001423 Walker A motif; other site 471853001424 ATP binding site [chemical binding]; other site 471853001425 Walker B motif; other site 471853001426 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 471853001427 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 471853001428 recombination protein RecR; Reviewed; Region: recR; PRK00076 471853001429 RecR protein; Region: RecR; pfam02132 471853001430 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 471853001431 putative active site [active] 471853001432 putative metal-binding site [ion binding]; other site 471853001433 tetramer interface [polypeptide binding]; other site 471853001434 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 471853001435 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 471853001436 Walker A/P-loop; other site 471853001437 ATP binding site [chemical binding]; other site 471853001438 Q-loop/lid; other site 471853001439 ABC transporter signature motif; other site 471853001440 Walker B; other site 471853001441 D-loop; other site 471853001442 H-loop/switch region; other site 471853001443 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 471853001444 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853001445 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853001446 dimer interface [polypeptide binding]; other site 471853001447 conserved gate region; other site 471853001448 putative PBP binding loops; other site 471853001449 ABC-ATPase subunit interface; other site 471853001450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853001451 dimer interface [polypeptide binding]; other site 471853001452 conserved gate region; other site 471853001453 putative PBP binding loops; other site 471853001454 ABC-ATPase subunit interface; other site 471853001455 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853001456 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853001457 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853001458 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853001459 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853001460 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 471853001461 active site 471853001462 catalytic tetrad [active] 471853001463 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853001464 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853001465 DNA binding site [nucleotide binding] 471853001466 domain linker motif; other site 471853001467 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853001468 dimerization interface [polypeptide binding]; other site 471853001469 ligand binding site [chemical binding]; other site 471853001470 aspartate kinase; Reviewed; Region: PRK06635 471853001471 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 471853001472 putative nucleotide binding site [chemical binding]; other site 471853001473 putative catalytic residues [active] 471853001474 putative Mg ion binding site [ion binding]; other site 471853001475 putative aspartate binding site [chemical binding]; other site 471853001476 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 471853001477 putative allosteric regulatory site; other site 471853001478 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 471853001479 putative allosteric regulatory residue; other site 471853001480 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 471853001481 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853001482 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 471853001483 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 471853001484 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 471853001485 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471853001486 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853001487 homodimer interface [polypeptide binding]; other site 471853001488 catalytic residue [active] 471853001489 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471853001490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853001491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853001492 H+ Antiporter protein; Region: 2A0121; TIGR00900 471853001493 putative substrate translocation pore; other site 471853001494 translocation protein TolB; Provisional; Region: tolB; PRK04792 471853001495 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 471853001496 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471853001497 Bacterial Ig-like domain; Region: Big_5; cl01012 471853001498 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 471853001499 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 471853001500 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 471853001501 tetramer interface [polypeptide binding]; other site 471853001502 active site 471853001503 Mg2+/Mn2+ binding site [ion binding]; other site 471853001504 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471853001505 Sulfatase; Region: Sulfatase; cl10460 471853001506 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853001507 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853001508 dimer interface [polypeptide binding]; other site 471853001509 conserved gate region; other site 471853001510 putative PBP binding loops; other site 471853001511 ABC-ATPase subunit interface; other site 471853001512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853001513 dimer interface [polypeptide binding]; other site 471853001514 conserved gate region; other site 471853001515 putative PBP binding loops; other site 471853001516 ABC-ATPase subunit interface; other site 471853001517 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853001518 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 471853001519 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 471853001520 citrate synthase; Provisional; Region: PRK14033 471853001521 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 471853001522 oxalacetate binding site [chemical binding]; other site 471853001523 citrylCoA binding site [chemical binding]; other site 471853001524 coenzyme A binding site [chemical binding]; other site 471853001525 catalytic triad [active] 471853001526 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 471853001527 nudix motif; other site 471853001528 NeuB family; Region: NeuB; cl00496 471853001529 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 471853001530 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 471853001531 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 471853001532 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471853001533 catalytic residue [active] 471853001534 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853001535 D-galactonate transporter; Region: 2A0114; TIGR00893 471853001536 putative substrate translocation pore; other site 471853001537 membrane protein FdrA; Validated; Region: PRK06091 471853001538 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853001539 CoA-ligase; Region: Ligase_CoA; cl02894 471853001540 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 471853001541 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 471853001542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853001543 D-galactonate transporter; Region: 2A0114; TIGR00893 471853001544 putative substrate translocation pore; other site 471853001545 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 471853001546 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 471853001547 putative substrate binding site [chemical binding]; other site 471853001548 nucleotide binding site [chemical binding]; other site 471853001549 nucleotide binding site [chemical binding]; other site 471853001550 homodimer interface [polypeptide binding]; other site 471853001551 Transcriptional regulators [Transcription]; Region: GntR; COG1802 471853001552 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853001553 DNA-binding site [nucleotide binding]; DNA binding site 471853001554 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 471853001555 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471853001556 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853001557 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853001558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853001559 active site 471853001560 phosphorylation site [posttranslational modification] 471853001561 intermolecular recognition site; other site 471853001562 dimerization interface [polypeptide binding]; other site 471853001563 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853001564 DNA binding residues [nucleotide binding] 471853001565 dimerization interface [polypeptide binding]; other site 471853001566 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471853001567 Histidine kinase; Region: HisKA_3; pfam07730 471853001568 SAF domain; Region: SAF; cl00555 471853001569 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 471853001570 Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721 471853001571 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 471853001572 active site 471853001573 trimer interface [polypeptide binding]; other site 471853001574 allosteric site; other site 471853001575 active site lid [active] 471853001576 hexamer (dimer of trimers) interface [polypeptide binding]; other site 471853001577 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471853001578 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 471853001579 active site 471853001580 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853001581 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853001582 DNA binding site [nucleotide binding] 471853001583 domain linker motif; other site 471853001584 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853001585 dimerization interface [polypeptide binding]; other site 471853001586 ligand binding site [chemical binding]; other site 471853001587 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853001588 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853001589 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 471853001590 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 471853001591 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 471853001592 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471853001593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853001594 dimer interface [polypeptide binding]; other site 471853001595 conserved gate region; other site 471853001596 putative PBP binding loops; other site 471853001597 ABC-ATPase subunit interface; other site 471853001598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853001599 dimer interface [polypeptide binding]; other site 471853001600 conserved gate region; other site 471853001601 putative PBP binding loops; other site 471853001602 ABC-ATPase subunit interface; other site 471853001603 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 471853001604 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471853001605 Walker A/P-loop; other site 471853001606 ATP binding site [chemical binding]; other site 471853001607 Q-loop/lid; other site 471853001608 ABC transporter signature motif; other site 471853001609 Walker B; other site 471853001610 D-loop; other site 471853001611 H-loop/switch region; other site 471853001612 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471853001613 Walker A/P-loop; other site 471853001614 ATP binding site [chemical binding]; other site 471853001615 Q-loop/lid; other site 471853001616 ABC transporter signature motif; other site 471853001617 Walker B; other site 471853001618 D-loop; other site 471853001619 H-loop/switch region; other site 471853001620 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853001621 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853001622 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 471853001623 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 471853001624 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 471853001625 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 471853001626 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471853001627 putative active site [active] 471853001628 putative metal binding site [ion binding]; other site 471853001629 Transglycosylase; Region: Transgly; cl07896 471853001630 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 471853001631 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 471853001632 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471853001633 Transcription factor WhiB; Region: Whib; pfam02467 471853001634 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 471853001635 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 471853001636 homotrimer interaction site [polypeptide binding]; other site 471853001637 putative active site [active] 471853001638 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 471853001639 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471853001640 ligand binding site [chemical binding]; other site 471853001641 flexible hinge region; other site 471853001642 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 471853001643 putative switch regulator; other site 471853001644 non-specific DNA interactions [nucleotide binding]; other site 471853001645 DNA binding site [nucleotide binding] 471853001646 sequence specific DNA binding site [nucleotide binding]; other site 471853001647 putative cAMP binding site [chemical binding]; other site 471853001648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853001649 S-adenosylmethionine binding site [chemical binding]; other site 471853001650 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471853001651 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853001652 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471853001653 acetyl-CoA synthetase; Provisional; Region: PRK00174 471853001654 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 471853001655 AMP-binding enzyme; Region: AMP-binding; cl15778 471853001656 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471853001657 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471853001658 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853001659 bacterio-opsin activator; Provisional; Region: PRK13558 471853001660 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 471853001661 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 471853001662 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 471853001663 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 471853001664 Type II/IV secretion system protein; Region: T2SE; pfam00437 471853001665 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 471853001666 ATP binding site [chemical binding]; other site 471853001667 Walker A motif; other site 471853001668 hexamer interface [polypeptide binding]; other site 471853001669 Walker B motif; other site 471853001670 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 471853001671 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471853001672 ATP binding site [chemical binding]; other site 471853001673 putative Mg++ binding site [ion binding]; other site 471853001674 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 471853001675 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471853001676 DNA binding site [nucleotide binding] 471853001677 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 471853001678 active site 471853001679 catalytic triad [active] 471853001680 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 471853001681 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 471853001682 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 471853001683 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 471853001684 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471853001685 anti sigma factor interaction site; other site 471853001686 regulatory phosphorylation site [posttranslational modification]; other site 471853001687 arginine-tRNA ligase; Region: PLN02286 471853001688 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 471853001689 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 471853001690 active site 471853001691 HIGH motif; other site 471853001692 KMSK motif region; other site 471853001693 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 471853001694 tRNA binding surface [nucleotide binding]; other site 471853001695 anticodon binding site; other site 471853001696 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 471853001697 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471853001698 DNA binding residues [nucleotide binding] 471853001699 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 471853001700 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 471853001701 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 471853001702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853001703 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 471853001704 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 471853001705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853001706 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 471853001707 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 471853001708 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853001709 NAD(P) binding site [chemical binding]; other site 471853001710 active site 471853001711 KduI/IolB family; Region: KduI; cl01508 471853001712 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 471853001713 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 471853001714 active site pocket [active] 471853001715 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471853001716 Helix-turn-helix domains; Region: HTH; cl00088 471853001717 Bacterial transcriptional regulator; Region: IclR; pfam01614 471853001718 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853001719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853001720 dimer interface [polypeptide binding]; other site 471853001721 conserved gate region; other site 471853001722 putative PBP binding loops; other site 471853001723 ABC-ATPase subunit interface; other site 471853001724 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853001725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853001726 dimer interface [polypeptide binding]; other site 471853001727 ABC-ATPase subunit interface; other site 471853001728 putative PBP binding loops; other site 471853001729 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853001730 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853001731 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853001732 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 471853001733 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853001734 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 471853001735 putative hydrophobic ligand binding site [chemical binding]; other site 471853001736 CLM binding site; other site 471853001737 L1 loop; other site 471853001738 DNA binding site [nucleotide binding] 471853001739 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 471853001740 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 471853001741 putative DNA binding site [nucleotide binding]; other site 471853001742 putative homodimer interface [polypeptide binding]; other site 471853001743 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 471853001744 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 471853001745 nucleotide binding site [chemical binding]; other site 471853001746 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 471853001747 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 471853001748 active site 471853001749 DNA binding site [nucleotide binding] 471853001750 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 471853001751 DNA binding site [nucleotide binding] 471853001752 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853001753 Helix-turn-helix domains; Region: HTH; cl00088 471853001754 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853001755 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471853001756 active site 471853001757 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 471853001758 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 471853001759 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 471853001760 active site 471853001761 interdomain interaction site; other site 471853001762 putative metal-binding site [ion binding]; other site 471853001763 nucleotide binding site [chemical binding]; other site 471853001764 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 471853001765 domain I; other site 471853001766 phosphate binding site [ion binding]; other site 471853001767 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 471853001768 domain II; other site 471853001769 domain III; other site 471853001770 nucleotide binding site [chemical binding]; other site 471853001771 DNA binding groove [nucleotide binding] 471853001772 catalytic site [active] 471853001773 domain IV; other site 471853001774 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 471853001775 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 471853001776 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853001777 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853001778 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 471853001779 DinB superfamily; Region: DinB_2; pfam12867 471853001780 thymidylate kinase; Validated; Region: tmk; PRK00698 471853001781 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 471853001782 TMP-binding site; other site 471853001783 ATP-binding site [chemical binding]; other site 471853001784 DNA polymerase III subunit delta'; Validated; Region: PRK07940 471853001785 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853001786 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 471853001787 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471853001788 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 471853001789 nucleotide binding site [chemical binding]; other site 471853001790 Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 471853001791 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471853001792 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471853001793 DNA binding residues [nucleotide binding] 471853001794 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 471853001795 DNA-binding site [nucleotide binding]; DNA binding site 471853001796 RNA-binding motif; other site 471853001797 Fatty acid desaturase; Region: FA_desaturase; pfam00487 471853001798 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 471853001799 putative di-iron ligands [ion binding]; other site 471853001800 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 471853001801 nudix motif; other site 471853001802 Helix-turn-helix domains; Region: HTH; cl00088 471853001803 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 471853001804 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853001805 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 471853001806 Walker A/P-loop; other site 471853001807 ATP binding site [chemical binding]; other site 471853001808 Q-loop/lid; other site 471853001809 ABC transporter signature motif; other site 471853001810 Walker B; other site 471853001811 D-loop; other site 471853001812 H-loop/switch region; other site 471853001813 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471853001814 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853001815 NADH(P)-binding; Region: NAD_binding_10; pfam13460 471853001816 NAD(P) binding site [chemical binding]; other site 471853001817 active site 471853001818 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 471853001819 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853001820 active site 471853001821 catalytic tetrad [active] 471853001822 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 471853001823 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471853001824 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853001825 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471853001826 DNA binding residues [nucleotide binding] 471853001827 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 471853001828 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 471853001829 active site 471853001830 catalytic site [active] 471853001831 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471853001832 FAD binding domain; Region: FAD_binding_4; pfam01565 471853001833 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 471853001834 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 471853001835 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 471853001836 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 471853001837 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 471853001838 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 471853001839 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471853001840 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 471853001841 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 471853001842 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 471853001843 homodimer interface [polypeptide binding]; other site 471853001844 substrate-cofactor binding pocket; other site 471853001845 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853001846 catalytic residue [active] 471853001847 NlpC/P60 family; Region: NLPC_P60; cl11438 471853001848 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 471853001849 dimer interface [polypeptide binding]; other site 471853001850 substrate binding site [chemical binding]; other site 471853001851 metal binding sites [ion binding]; metal-binding site 471853001852 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 471853001853 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 471853001854 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 471853001855 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 471853001856 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471853001857 active site 471853001858 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 471853001859 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471853001860 Walker A motif; other site 471853001861 ATP binding site [chemical binding]; other site 471853001862 Walker B motif; other site 471853001863 arginine finger; other site 471853001864 Peptidase family M41; Region: Peptidase_M41; pfam01434 471853001865 GTP cyclohydrolase I; Provisional; Region: PLN03044 471853001866 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 471853001867 homodecamer interface [polypeptide binding]; other site 471853001868 active site 471853001869 putative catalytic site residues [active] 471853001870 zinc binding site [ion binding]; other site 471853001871 GTP-CH-I/GFRP interaction surface; other site 471853001872 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 471853001873 dihydropteroate synthase; Region: DHPS; TIGR01496 471853001874 substrate binding pocket [chemical binding]; other site 471853001875 dimer interface [polypeptide binding]; other site 471853001876 inhibitor binding site; inhibition site 471853001877 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 471853001878 active site 471853001879 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 471853001880 catalytic center binding site [active] 471853001881 ATP binding site [chemical binding]; other site 471853001882 Bacterial PH domain; Region: DUF304; cl01348 471853001883 Bacterial PH domain; Region: DUF304; cl01348 471853001884 Predicted membrane protein [Function unknown]; Region: COG3428 471853001885 Bacterial PH domain; Region: DUF304; cl01348 471853001886 Bacterial PH domain; Region: DUF304; cl01348 471853001887 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 471853001888 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 471853001889 nudix motif; other site 471853001890 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471853001891 Helix-turn-helix domains; Region: HTH; cl00088 471853001892 Helix-turn-helix domains; Region: HTH; cl00088 471853001893 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471853001894 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853001895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853001896 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 471853001897 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471853001898 active site 471853001899 nucleotide binding site [chemical binding]; other site 471853001900 HIGH motif; other site 471853001901 KMSKS motif; other site 471853001902 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853001903 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853001904 active site 471853001905 phosphorylation site [posttranslational modification] 471853001906 intermolecular recognition site; other site 471853001907 dimerization interface [polypeptide binding]; other site 471853001908 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853001909 DNA binding residues [nucleotide binding] 471853001910 dimerization interface [polypeptide binding]; other site 471853001911 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471853001912 Histidine kinase; Region: HisKA_3; pfam07730 471853001913 Predicted membrane protein [Function unknown]; Region: COG2311 471853001914 Protein of unknown function (DUF418); Region: DUF418; cl12135 471853001915 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 471853001916 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 471853001917 dimer interface [polypeptide binding]; other site 471853001918 putative anticodon binding site; other site 471853001919 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 471853001920 motif 1; other site 471853001921 dimer interface [polypeptide binding]; other site 471853001922 active site 471853001923 motif 2; other site 471853001924 motif 3; other site 471853001925 Lsr2; Region: Lsr2; pfam11774 471853001926 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 471853001927 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 471853001928 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853001929 DNA-binding site [nucleotide binding]; DNA binding site 471853001930 UTRA domain; Region: UTRA; cl01230 471853001931 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471853001932 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 471853001933 substrate binding site [chemical binding]; other site 471853001934 ATP binding site [chemical binding]; other site 471853001935 KduI/IolB family; Region: KduI; cl01508 471853001936 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 471853001937 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 471853001938 PYR/PP interface [polypeptide binding]; other site 471853001939 dimer interface [polypeptide binding]; other site 471853001940 TPP binding site [chemical binding]; other site 471853001941 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 471853001942 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 471853001943 TPP-binding site; other site 471853001944 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 471853001945 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471853001946 tetrameric interface [polypeptide binding]; other site 471853001947 NAD binding site [chemical binding]; other site 471853001948 catalytic residues [active] 471853001949 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471853001950 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853001951 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 471853001952 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471853001953 catalytic core [active] 471853001954 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471853001955 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471853001956 Sulfatase; Region: Sulfatase; cl10460 471853001957 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 471853001958 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 471853001959 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 471853001960 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471853001961 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 471853001962 tetramerization interface [polypeptide binding]; other site 471853001963 NAD(P) binding site [chemical binding]; other site 471853001964 catalytic residues [active] 471853001965 Short C-terminal domain; Region: SHOCT; cl01373 471853001966 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471853001967 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 471853001968 DNA binding residues [nucleotide binding] 471853001969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853001970 putative substrate translocation pore; other site 471853001971 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 471853001972 Helix-turn-helix domains; Region: HTH; cl00088 471853001973 WYL domain; Region: WYL; cl14852 471853001974 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 471853001975 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471853001976 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 471853001977 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853001978 DNA binding residues [nucleotide binding] 471853001979 dimerization interface [polypeptide binding]; other site 471853001980 Protease prsW family; Region: PrsW-protease; cl15823 471853001981 Sulfate transporter family; Region: Sulfate_transp; cl15842 471853001982 high affinity sulphate transporter 1; Region: sulP; TIGR00815 471853001983 Sulfate transporter family; Region: Sulfate_transp; cl15842 471853001984 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 471853001985 Mechanosensitive ion channel; Region: MS_channel; pfam00924 471853001986 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 471853001987 Sulfate transporter family; Region: Sulfate_transp; cl15842 471853001988 Sulfate transporter family; Region: Sulfate_transp; cl15842 471853001989 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 471853001990 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 471853001991 Helix-turn-helix domains; Region: HTH; cl00088 471853001992 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853001993 dimerization interface [polypeptide binding]; other site 471853001994 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 471853001995 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 471853001996 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 471853001997 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471853001998 Sulfatase; Region: Sulfatase; cl10460 471853001999 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471853002000 Sulfatase; Region: Sulfatase; cl10460 471853002001 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471853002002 Sulfatase; Region: Sulfatase; cl10460 471853002003 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 471853002004 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 471853002005 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853002006 Q-loop/lid; other site 471853002007 ABC transporter signature motif; other site 471853002008 Walker B; other site 471853002009 D-loop; other site 471853002010 Sulfate transporter family; Region: Sulfate_transp; cl15842 471853002011 Sulfate transporter family; Region: Sulfate_transp; cl15842 471853002012 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 471853002013 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853002014 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853002015 DNA binding residues [nucleotide binding] 471853002016 dimerization interface [polypeptide binding]; other site 471853002017 DinB superfamily; Region: DinB_2; pfam12867 471853002018 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 471853002019 PhoU domain; Region: PhoU; pfam01895 471853002020 PhoU domain; Region: PhoU; pfam01895 471853002021 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 471853002022 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471853002023 dimer interface [polypeptide binding]; other site 471853002024 phosphorylation site [posttranslational modification] 471853002025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471853002026 ATP binding site [chemical binding]; other site 471853002027 Mg2+ binding site [ion binding]; other site 471853002028 G-X-G motif; other site 471853002029 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471853002030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853002031 active site 471853002032 phosphorylation site [posttranslational modification] 471853002033 intermolecular recognition site; other site 471853002034 dimerization interface [polypeptide binding]; other site 471853002035 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471853002036 DNA binding site [nucleotide binding] 471853002037 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 471853002038 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 471853002039 substrate binding site; other site 471853002040 dimer interface; other site 471853002041 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cl10030 471853002042 homotrimer interaction site [polypeptide binding]; other site 471853002043 zinc binding site [ion binding]; other site 471853002044 CDP-binding sites; other site 471853002045 Helix-turn-helix domains; Region: HTH; cl00088 471853002046 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471853002047 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 471853002048 MTABC3 (also known as ABCB6) is a mitochondrial ATP-binding cassette protein involved in iron homeostasis and one of four ABC transporters expressed in the mitochondrial inner membrane, the other three being MDL1(ABC7), MDL2, and ATM1. In fact, the...; Region: ABC_MTABC3_MDL1_MDL2; cd03249 471853002049 Walker A/P-loop; other site 471853002050 ATP binding site [chemical binding]; other site 471853002051 Q-loop/lid; other site 471853002052 ABC transporter signature motif; other site 471853002053 Walker B; other site 471853002054 D-loop; other site 471853002055 H-loop/switch region; other site 471853002056 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 471853002057 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 471853002058 DNA binding site [nucleotide binding] 471853002059 active site 471853002060 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 471853002061 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471853002062 active site 471853002063 HIGH motif; other site 471853002064 nucleotide binding site [chemical binding]; other site 471853002065 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 471853002066 KMSKS motif; other site 471853002067 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 471853002068 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 471853002069 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 471853002070 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 471853002071 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 471853002072 TM1410 hypothetical-related protein; Region: DUF297; cl00997 471853002073 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 471853002074 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471853002075 Walker A/P-loop; other site 471853002076 ATP binding site [chemical binding]; other site 471853002077 Q-loop/lid; other site 471853002078 ABC transporter signature motif; other site 471853002079 Walker B; other site 471853002080 D-loop; other site 471853002081 H-loop/switch region; other site 471853002082 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 471853002083 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 471853002084 Walker A/P-loop; other site 471853002085 ATP binding site [chemical binding]; other site 471853002086 Q-loop/lid; other site 471853002087 ABC transporter signature motif; other site 471853002088 Walker B; other site 471853002089 D-loop; other site 471853002090 H-loop/switch region; other site 471853002091 TOBE domain; Region: TOBE_2; cl01440 471853002092 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 471853002093 dimer interface [polypeptide binding]; other site 471853002094 NADP binding site [chemical binding]; other site 471853002095 catalytic residues [active] 471853002096 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 471853002097 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 471853002098 active site pocket [active] 471853002099 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 471853002100 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 471853002101 catalytic residue [active] 471853002102 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471853002103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853002104 NAD(P) binding site [chemical binding]; other site 471853002105 active site 471853002106 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853002107 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 471853002108 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853002109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853002110 dimer interface [polypeptide binding]; other site 471853002111 conserved gate region; other site 471853002112 putative PBP binding loops; other site 471853002113 ABC-ATPase subunit interface; other site 471853002114 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853002115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853002116 ABC-ATPase subunit interface; other site 471853002117 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853002118 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853002119 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853002120 DNA binding site [nucleotide binding] 471853002121 domain linker motif; other site 471853002122 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853002123 dimerization interface [polypeptide binding]; other site 471853002124 ligand binding site [chemical binding]; other site 471853002125 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 471853002126 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 471853002127 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 471853002128 active site 471853002129 homotetramer interface [polypeptide binding]; other site 471853002130 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471853002131 active site 471853002132 ATP binding site [chemical binding]; other site 471853002133 substrate binding site [chemical binding]; other site 471853002134 activation loop (A-loop); other site 471853002135 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471853002136 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 471853002137 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 471853002138 putative dimerization interface [polypeptide binding]; other site 471853002139 putative ligand binding site [chemical binding]; other site 471853002140 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 471853002141 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853002142 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853002143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853002144 dimer interface [polypeptide binding]; other site 471853002145 conserved gate region; other site 471853002146 putative PBP binding loops; other site 471853002147 ABC-ATPase subunit interface; other site 471853002148 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853002149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853002150 dimer interface [polypeptide binding]; other site 471853002151 conserved gate region; other site 471853002152 putative PBP binding loops; other site 471853002153 ABC-ATPase subunit interface; other site 471853002154 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853002155 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853002156 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 471853002157 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853002158 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 471853002159 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853002160 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853002161 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 471853002162 classical (c) SDRs; Region: SDR_c; cd05233 471853002163 NAD(P) binding site [chemical binding]; other site 471853002164 active site 471853002165 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853002166 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853002167 PQQ-like domain; Region: PQQ_2; pfam13360 471853002168 PQQ-like domain; Region: PQQ_2; pfam13360 471853002169 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 471853002170 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471853002171 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 471853002172 active site 471853002173 catalytic triad [active] 471853002174 oxyanion hole [active] 471853002175 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 471853002176 ligand binding site [chemical binding]; other site 471853002177 active site 471853002178 UGI interface [polypeptide binding]; other site 471853002179 catalytic site [active] 471853002180 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 471853002181 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 471853002182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853002183 Predicted dehydrogenase [General function prediction only]; Region: COG0579 471853002184 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 471853002185 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853002186 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 471853002187 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 471853002188 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 471853002189 ring oligomerisation interface [polypeptide binding]; other site 471853002190 ATP/Mg binding site [chemical binding]; other site 471853002191 stacking interactions; other site 471853002192 hinge regions; other site 471853002193 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 471853002194 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 471853002195 MgtC family; Region: MgtC; pfam02308 471853002196 FOG: CBS domain [General function prediction only]; Region: COG0517 471853002197 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 471853002198 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853002199 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853002200 DNA binding site [nucleotide binding] 471853002201 domain linker motif; other site 471853002202 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 471853002203 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 471853002204 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 471853002205 substrate binding [chemical binding]; other site 471853002206 active site 471853002207 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853002208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853002209 dimer interface [polypeptide binding]; other site 471853002210 conserved gate region; other site 471853002211 putative PBP binding loops; other site 471853002212 ABC-ATPase subunit interface; other site 471853002213 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853002214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853002215 dimer interface [polypeptide binding]; other site 471853002216 conserved gate region; other site 471853002217 putative PBP binding loops; other site 471853002218 ABC-ATPase subunit interface; other site 471853002219 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853002220 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853002221 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 471853002222 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 471853002223 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471853002224 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853002225 NAD(P) binding site [chemical binding]; other site 471853002226 active site 471853002227 Helix-turn-helix domains; Region: HTH; cl00088 471853002228 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 471853002229 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 471853002230 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853002231 NAD(P) binding site [chemical binding]; other site 471853002232 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 471853002233 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 471853002234 substrate-cofactor binding pocket; other site 471853002235 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853002236 catalytic residue [active] 471853002237 Proteins of 100 residues with WXG; Region: WXG100; cl02005 471853002238 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 471853002239 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 471853002240 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 471853002241 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471853002242 dimer interface [polypeptide binding]; other site 471853002243 phosphorylation site [posttranslational modification] 471853002244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471853002245 Mg2+ binding site [ion binding]; other site 471853002246 G-X-G motif; other site 471853002247 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471853002248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853002249 active site 471853002250 phosphorylation site [posttranslational modification] 471853002251 intermolecular recognition site; other site 471853002252 dimerization interface [polypeptide binding]; other site 471853002253 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471853002254 DNA binding site [nucleotide binding] 471853002255 LabA_like proteins; Region: LabA_like; cd06167 471853002256 putative metal binding site [ion binding]; other site 471853002257 PspA/IM30 family; Region: PspA_IM30; pfam04012 471853002258 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 471853002259 catalytic triad [active] 471853002260 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 471853002261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853002262 putative substrate translocation pore; other site 471853002263 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 471853002264 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 471853002265 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471853002266 ATP binding site [chemical binding]; other site 471853002267 putative Mg++ binding site [ion binding]; other site 471853002268 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471853002269 nucleotide binding region [chemical binding]; other site 471853002270 ATP-binding site [chemical binding]; other site 471853002271 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 471853002272 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 471853002273 DNA-binding site [nucleotide binding]; DNA binding site 471853002274 RNA-binding motif; other site 471853002275 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 471853002276 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 471853002277 putative metal binding residues [ion binding]; other site 471853002278 signature motif; other site 471853002279 dimer interface [polypeptide binding]; other site 471853002280 polyP binding site; other site 471853002281 active site 471853002282 substrate binding site [chemical binding]; other site 471853002283 acceptor-phosphate pocket; other site 471853002284 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471853002285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853002286 active site 471853002287 phosphorylation site [posttranslational modification] 471853002288 intermolecular recognition site; other site 471853002289 dimerization interface [polypeptide binding]; other site 471853002290 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471853002291 DNA binding site [nucleotide binding] 471853002292 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 471853002293 putative binding surface; other site 471853002294 active site 471853002295 Response regulator receiver domain; Region: Response_reg; pfam00072 471853002296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853002297 active site 471853002298 phosphorylation site [posttranslational modification] 471853002299 intermolecular recognition site; other site 471853002300 dimerization interface [polypeptide binding]; other site 471853002301 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 471853002302 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471853002303 putative active site [active] 471853002304 heme pocket [chemical binding]; other site 471853002305 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471853002306 dimer interface [polypeptide binding]; other site 471853002307 phosphorylation site [posttranslational modification] 471853002308 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471853002309 ATP binding site [chemical binding]; other site 471853002310 Mg2+ binding site [ion binding]; other site 471853002311 G-X-G motif; other site 471853002312 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC); Region: PvlArgDC; cl00849 471853002313 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 471853002314 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 471853002315 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471853002316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853002317 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 471853002318 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 471853002319 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 471853002320 tetramer interface [polypeptide binding]; other site 471853002321 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 471853002322 tetramer interface [polypeptide binding]; other site 471853002323 active site 471853002324 metal binding site [ion binding]; metal-binding site 471853002325 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 471853002326 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471853002327 NAD(P) binding site [chemical binding]; other site 471853002328 catalytic residues [active] 471853002329 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 471853002330 dihydrodipicolinate synthase; Region: dapA; TIGR00674 471853002331 dimer interface [polypeptide binding]; other site 471853002332 active site 471853002333 catalytic residue [active] 471853002334 hypothetical protein; Provisional; Region: PRK12764 471853002335 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 471853002336 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 471853002337 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 471853002338 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 471853002339 Flavin Reductases; Region: FlaRed; cl00801 471853002340 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471853002341 Helix-turn-helix domains; Region: HTH; cl00088 471853002342 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 471853002343 PYR/PP interface [polypeptide binding]; other site 471853002344 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 471853002345 dimer interface [polypeptide binding]; other site 471853002346 TPP binding site [chemical binding]; other site 471853002347 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 471853002348 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 471853002349 TPP-binding site [chemical binding]; other site 471853002350 Helix-turn-helix domains; Region: HTH; cl00088 471853002351 H+ Antiporter protein; Region: 2A0121; TIGR00900 471853002352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853002353 putative substrate translocation pore; other site 471853002354 HNH/ENDO VII superfamily nuclease with conserved GHE residues; Region: GH-E; pfam14410 471853002355 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 471853002356 Protein of unknown function (DUF2185); Region: DUF2185; cl02019 471853002357 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 471853002358 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471853002359 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471853002360 catalytic residue [active] 471853002361 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 471853002362 Citrate synthase; Region: Citrate_synt; pfam00285 471853002363 citrylCoA binding site [chemical binding]; other site 471853002364 oxalacetate binding site [chemical binding]; other site 471853002365 coenzyme A binding site [chemical binding]; other site 471853002366 catalytic triad [active] 471853002367 Helix-turn-helix domains; Region: HTH; cl00088 471853002368 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 471853002369 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 471853002370 FeoA domain; Region: FeoA; cl00838 471853002371 NlpC/P60 family; Region: NLPC_P60; cl11438 471853002372 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471853002373 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471853002374 Ligand Binding Site [chemical binding]; other site 471853002375 Domain of unknown function (DUF305); Region: DUF305; cl15795 471853002376 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471853002377 ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885 471853002378 inhibitor-cofactor binding pocket; inhibition site 471853002379 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853002380 catalytic residue [active] 471853002381 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 471853002382 Amidinotransferase; Region: Amidinotransf; cl12043 471853002383 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 471853002384 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 471853002385 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853002386 motif II; other site 471853002387 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl01922 471853002388 Asp-box motif; other site 471853002389 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 471853002390 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853002391 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853002392 DNA binding site [nucleotide binding] 471853002393 domain linker motif; other site 471853002394 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853002395 dimerization interface [polypeptide binding]; other site 471853002396 ligand binding site [chemical binding]; other site 471853002397 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 471853002398 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 471853002399 active site 471853002400 catalytic site [active] 471853002401 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853002402 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853002403 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853002404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853002405 dimer interface [polypeptide binding]; other site 471853002406 conserved gate region; other site 471853002407 putative PBP binding loops; other site 471853002408 ABC-ATPase subunit interface; other site 471853002409 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853002410 benzoate transport; Region: 2A0115; TIGR00895 471853002411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853002412 putative substrate translocation pore; other site 471853002413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853002414 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 471853002415 putative active site [active] 471853002416 catalytic triad [active] 471853002417 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 471853002418 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 471853002419 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 471853002420 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 471853002421 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 471853002422 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 471853002423 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 471853002424 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 471853002425 active site 471853002426 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 471853002427 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 471853002428 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 471853002429 dimer interface [polypeptide binding]; other site 471853002430 putative functional site; other site 471853002431 putative MPT binding site; other site 471853002432 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853002433 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 471853002434 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471853002435 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853002436 NAD(P) binding site [chemical binding]; other site 471853002437 active site 471853002438 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 471853002439 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 471853002440 metal binding site [ion binding]; metal-binding site 471853002441 substrate binding pocket [chemical binding]; other site 471853002442 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853002443 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853002444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853002445 dimer interface [polypeptide binding]; other site 471853002446 conserved gate region; other site 471853002447 putative PBP binding loops; other site 471853002448 ABC-ATPase subunit interface; other site 471853002449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853002450 dimer interface [polypeptide binding]; other site 471853002451 conserved gate region; other site 471853002452 putative PBP binding loops; other site 471853002453 ABC-ATPase subunit interface; other site 471853002454 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853002455 DNA binding site [nucleotide binding] 471853002456 domain linker motif; other site 471853002457 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853002458 dimerization interface [polypeptide binding]; other site 471853002459 ligand binding site [chemical binding]; other site 471853002460 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 471853002461 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_5; cd09621 471853002462 putative ligand binding site [chemical binding]; other site 471853002463 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 471853002464 AP (apurinic/apyrimidinic) site pocket; other site 471853002465 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471853002466 DNA interaction; other site 471853002467 Metal-binding active site; metal-binding site 471853002468 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853002469 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853002470 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853002471 dimerization interface [polypeptide binding]; other site 471853002472 ligand binding site [chemical binding]; other site 471853002473 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853002474 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853002475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853002476 dimer interface [polypeptide binding]; other site 471853002477 conserved gate region; other site 471853002478 putative PBP binding loops; other site 471853002479 ABC-ATPase subunit interface; other site 471853002480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853002481 dimer interface [polypeptide binding]; other site 471853002482 conserved gate region; other site 471853002483 putative PBP binding loops; other site 471853002484 ABC-ATPase subunit interface; other site 471853002485 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853002486 DNA binding residues [nucleotide binding] 471853002487 dimerization interface [polypeptide binding]; other site 471853002488 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 471853002489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853002490 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 471853002491 putative active site [active] 471853002492 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471853002493 active site 471853002494 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 471853002495 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471853002496 FAD binding domain; Region: FAD_binding_4; pfam01565 471853002497 Helix-turn-helix domains; Region: HTH; cl00088 471853002498 Helix-turn-helix domains; Region: HTH; cl00088 471853002499 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853002500 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471853002501 active site 471853002502 catalytic tetrad [active] 471853002503 Domain of unknown function (DUF385); Region: DUF385; cl04387 471853002504 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 471853002505 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471853002506 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471853002507 catalytic residue [active] 471853002508 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 471853002509 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 471853002510 putative dimer interface [polypeptide binding]; other site 471853002511 N-terminal domain interface [polypeptide binding]; other site 471853002512 putative substrate binding pocket (H-site) [chemical binding]; other site 471853002513 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 471853002514 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471853002515 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853002516 Cupin domain; Region: Cupin_2; cl09118 471853002517 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471853002518 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853002519 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471853002520 binding surface 471853002521 TPR motif; other site 471853002522 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 471853002523 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853002524 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853002525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853002526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853002527 putative PBP binding loops; other site 471853002528 ABC-ATPase subunit interface; other site 471853002529 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853002530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853002531 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 471853002532 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 471853002533 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471853002534 metal ion-dependent adhesion site (MIDAS); other site 471853002535 Helix-turn-helix domains; Region: HTH; cl00088 471853002536 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 471853002537 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 471853002538 active site 471853002539 Protein of unknown function (DUF419); Region: DUF419; cl15265 471853002540 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 471853002541 Predicted methyltransferases [General function prediction only]; Region: COG0313 471853002542 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 471853002543 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 471853002544 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853002545 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471853002546 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 471853002547 PA14 domain; Region: PA14; cl08459 471853002548 PA14 domain; Region: PA14; cl08459 471853002549 PA14 domain; Region: PA14; cl08459 471853002550 PA14 domain; Region: PA14; cl08459 471853002551 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 471853002552 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 471853002553 Bacterial Ig-like domain; Region: Big_5; cl01012 471853002554 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 471853002555 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 471853002556 Isochorismatase family; Region: Isochorismatase; pfam00857 471853002557 catalytic triad [active] 471853002558 metal binding site [ion binding]; metal-binding site 471853002559 conserved cis-peptide bond; other site 471853002560 aminotransferase; Validated; Region: PRK08175 471853002561 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471853002562 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853002563 homodimer interface [polypeptide binding]; other site 471853002564 catalytic residue [active] 471853002565 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 471853002566 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471853002567 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 471853002568 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853002569 Family description; Region: UvrD_C_2; cl15862 471853002570 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471853002571 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853002572 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 471853002573 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 471853002574 MMPL family; Region: MMPL; pfam03176 471853002575 Transport protein; Region: actII; TIGR00833 471853002576 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471853002577 Helix-turn-helix domains; Region: HTH; cl00088 471853002578 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 471853002579 active site 471853002580 metal binding site [ion binding]; metal-binding site 471853002581 nudix motif; other site 471853002582 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 471853002583 substrate binding pocket [chemical binding]; other site 471853002584 substrate-Mg2+ binding site; other site 471853002585 aspartate-rich region 1; other site 471853002586 aspartate-rich region 2; other site 471853002587 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 471853002588 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 471853002589 active site 471853002590 HIGH motif; other site 471853002591 KMSKS motif; other site 471853002592 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 471853002593 tRNA binding surface [nucleotide binding]; other site 471853002594 anticodon binding site; other site 471853002595 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 471853002596 active site 471853002597 Domain of unknown function (DUF348); Region: DUF348; pfam03990 471853002598 G5 domain; Region: G5; pfam07501 471853002599 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 471853002600 N-acetyl-D-glucosamine binding site [chemical binding]; other site 471853002601 catalytic residue [active] 471853002602 Domain of unknown function (DUF348); Region: DUF348; pfam03990 471853002603 Domain of unknown function (DUF348); Region: DUF348; pfam03990 471853002604 G5 domain; Region: G5; pfam07501 471853002605 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 471853002606 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853002607 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 471853002608 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471853002609 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 471853002610 ABC transporter; Region: ABC_tran_2; pfam12848 471853002611 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 471853002612 Low molecular weight phosphatase family; Region: LMWPc; cl00105 471853002613 active site 471853002614 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 471853002615 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 471853002616 trimer interface [polypeptide binding]; other site 471853002617 putative metal binding site [ion binding]; other site 471853002618 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471853002619 Helix-turn-helix domains; Region: HTH; cl00088 471853002620 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 471853002621 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 471853002622 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 471853002623 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 471853002624 Walker A/P-loop; other site 471853002625 ATP binding site [chemical binding]; other site 471853002626 Q-loop/lid; other site 471853002627 ABC transporter signature motif; other site 471853002628 Walker B; other site 471853002629 D-loop; other site 471853002630 H-loop/switch region; other site 471853002631 Predicted transcriptional regulators [Transcription]; Region: COG1725 471853002632 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853002633 DNA-binding site [nucleotide binding]; DNA binding site 471853002634 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853002635 Helix-turn-helix domains; Region: HTH; cl00088 471853002636 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 471853002637 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 471853002638 DXD motif; other site 471853002639 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 471853002640 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 471853002641 Substrate binding site; other site 471853002642 Mg++ binding site; other site 471853002643 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 471853002644 active site 471853002645 substrate binding site [chemical binding]; other site 471853002646 CoA binding site [chemical binding]; other site 471853002647 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 471853002648 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 471853002649 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471853002650 active site 471853002651 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 471853002652 putative active site [active] 471853002653 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 471853002654 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 471853002655 5S rRNA interface [nucleotide binding]; other site 471853002656 CTC domain interface [polypeptide binding]; other site 471853002657 L16 interface [polypeptide binding]; other site 471853002658 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 471853002659 putative active site [active] 471853002660 catalytic residue [active] 471853002661 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471853002662 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 471853002663 active site 471853002664 nucleotide binding site [chemical binding]; other site 471853002665 HIGH motif; other site 471853002666 KMSKS motif; other site 471853002667 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 471853002668 Probable Catalytic site; other site 471853002669 metal-binding site 471853002670 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 471853002671 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471853002672 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 471853002673 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 471853002674 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 471853002675 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 471853002676 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 471853002677 active site 471853002678 Right handed beta helix region; Region: Beta_helix; pfam13229 471853002679 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471853002680 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 471853002681 Chain length determinant protein; Region: Wzz; cl15801 471853002682 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 471853002683 MatE; Region: MatE; cl10513 471853002684 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471853002685 active site 471853002686 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 471853002687 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853002688 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 471853002689 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853002690 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 471853002691 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 471853002692 Ligand binding site; other site 471853002693 Putative Catalytic site; other site 471853002694 DXD motif; other site 471853002695 GtrA-like protein; Region: GtrA; cl00971 471853002696 Up-frameshift suppressor 2; Region: Upf2; pfam04050 471853002697 OpgC protein; Region: OpgC_C; cl00792 471853002698 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471853002699 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 471853002700 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853002701 Walker A/P-loop; other site 471853002702 ATP binding site [chemical binding]; other site 471853002703 Q-loop/lid; other site 471853002704 ABC transporter signature motif; other site 471853002705 Walker B; other site 471853002706 D-loop; other site 471853002707 H-loop/switch region; other site 471853002708 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 471853002709 putative active site pocket [active] 471853002710 dimerization interface [polypeptide binding]; other site 471853002711 putative catalytic residue [active] 471853002712 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 471853002713 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 471853002714 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471853002715 ATP binding site [chemical binding]; other site 471853002716 putative Mg++ binding site [ion binding]; other site 471853002717 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471853002718 nucleotide binding region [chemical binding]; other site 471853002719 ATP-binding site [chemical binding]; other site 471853002720 TRCF domain; Region: TRCF; cl04088 471853002721 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 471853002722 putative active site [active] 471853002723 putative metal binding site [ion binding]; other site 471853002724 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471853002725 catalytic core [active] 471853002726 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 471853002727 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 471853002728 enolase; Provisional; Region: eno; PRK00077 471853002729 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 471853002730 dimer interface [polypeptide binding]; other site 471853002731 metal binding site [ion binding]; metal-binding site 471853002732 substrate binding pocket [chemical binding]; other site 471853002733 Septum formation initiator; Region: DivIC; cl11433 471853002734 Protein of unknown function (DUF501); Region: DUF501; cl00652 471853002735 DNA polymerase IV; Validated; Region: PRK03858 471853002736 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 471853002737 active site 471853002738 DNA binding site [nucleotide binding] 471853002739 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 471853002740 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 471853002741 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471853002742 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 471853002743 putative dimer interface [polypeptide binding]; other site 471853002744 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853002745 ligand binding site [chemical binding]; other site 471853002746 Zn binding site [ion binding]; other site 471853002747 Helix-turn-helix domains; Region: HTH; cl00088 471853002748 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 471853002749 putative deacylase active site [active] 471853002750 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 471853002751 Fe-S cluster binding site [ion binding]; other site 471853002752 DNA binding site [nucleotide binding] 471853002753 active site 471853002754 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 471853002755 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853002756 Helix-turn-helix domains; Region: HTH; cl00088 471853002757 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 471853002758 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 471853002759 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853002760 Walker A/P-loop; other site 471853002761 ATP binding site [chemical binding]; other site 471853002762 Q-loop/lid; other site 471853002763 ABC transporter signature motif; other site 471853002764 Walker B; other site 471853002765 D-loop; other site 471853002766 H-loop/switch region; other site 471853002767 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471853002768 DNA polymerase IV; Validated; Region: PRK03352 471853002769 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 471853002770 active site 471853002771 DNA binding site [nucleotide binding] 471853002772 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853002773 NAD(P) binding site [chemical binding]; other site 471853002774 active site 471853002775 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471853002776 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 471853002777 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 471853002778 active site 471853002779 DNA binding site [nucleotide binding] 471853002780 catalytic site [active] 471853002781 Uncharacterized conserved protein [Function unknown]; Region: COG1432 471853002782 LabA_like proteins; Region: LabA_like; cd06167 471853002783 putative metal binding site [ion binding]; other site 471853002784 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cl14879 471853002785 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cl14879 471853002786 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 471853002787 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471853002788 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 471853002789 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853002790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853002791 active site 471853002792 phosphorylation site [posttranslational modification] 471853002793 intermolecular recognition site; other site 471853002794 dimerization interface [polypeptide binding]; other site 471853002795 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853002796 DNA binding residues [nucleotide binding] 471853002797 dimerization interface [polypeptide binding]; other site 471853002798 Histidine kinase; Region: HisKA_3; pfam07730 471853002799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471853002800 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471853002801 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471853002802 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 471853002803 Walker A/P-loop; other site 471853002804 ATP binding site [chemical binding]; other site 471853002805 Q-loop/lid; other site 471853002806 ABC transporter signature motif; other site 471853002807 Walker B; other site 471853002808 D-loop; other site 471853002809 H-loop/switch region; other site 471853002810 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 471853002811 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 471853002812 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 471853002813 dimer interface [polypeptide binding]; other site 471853002814 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853002815 catalytic residue [active] 471853002816 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 471853002817 cystathionine gamma-synthase; Provisional; Region: PRK07811 471853002818 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 471853002819 homodimer interface [polypeptide binding]; other site 471853002820 substrate-cofactor binding pocket; other site 471853002821 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853002822 catalytic residue [active] 471853002823 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 471853002824 putative hydrophobic ligand binding site [chemical binding]; other site 471853002825 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853002826 dimerization interface [polypeptide binding]; other site 471853002827 putative DNA binding site [nucleotide binding]; other site 471853002828 putative Zn2+ binding site [ion binding]; other site 471853002829 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 471853002830 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471853002831 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853002832 putative substrate translocation pore; other site 471853002833 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 471853002834 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 471853002835 DinB superfamily; Region: DinB_2; pfam12867 471853002836 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 471853002837 putative hydrophobic ligand binding site [chemical binding]; other site 471853002838 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901 471853002839 putative hydrophobic ligand binding site [chemical binding]; other site 471853002840 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853002841 dimerization interface [polypeptide binding]; other site 471853002842 putative DNA binding site [nucleotide binding]; other site 471853002843 putative Zn2+ binding site [ion binding]; other site 471853002844 hypothetical protein; Provisional; Region: PRK07945 471853002845 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 471853002846 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471853002847 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471853002848 active site 471853002849 metal binding site [ion binding]; metal-binding site 471853002850 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 471853002851 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 471853002852 Phosphotransferase enzyme family; Region: APH; pfam01636 471853002853 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 471853002854 substrate binding site [chemical binding]; other site 471853002855 Protein of unknown function (DUF503); Region: DUF503; cl00669 471853002856 TIGR03086 family protein; Region: TIGR03086 471853002857 NADH(P)-binding; Region: NAD_binding_10; pfam13460 471853002858 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853002859 NAD(P) binding site [chemical binding]; other site 471853002860 active site 471853002861 Helix-turn-helix domains; Region: HTH; cl00088 471853002862 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 471853002863 threonine dehydratase; Provisional; Region: PRK08198 471853002864 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 471853002865 tetramer interface [polypeptide binding]; other site 471853002866 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853002867 catalytic residue [active] 471853002868 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 471853002869 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 471853002870 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 471853002871 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 471853002872 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 471853002873 Predicted membrane protein [Function unknown]; Region: COG2311 471853002874 Protein of unknown function (DUF418); Region: DUF418; cl12135 471853002875 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 471853002876 preprotein translocase subunit SecY; Reviewed; Region: PRK08568 471853002877 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 471853002878 active site 471853002879 catalytic triad [active] 471853002880 dimer interface [polypeptide binding]; other site 471853002881 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 471853002882 Haemolysin-III related; Region: HlyIII; cl03831 471853002883 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 471853002884 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 471853002885 catalytic residue [active] 471853002886 putative FPP diphosphate binding site; other site 471853002887 putative FPP binding hydrophobic cleft; other site 471853002888 dimer interface [polypeptide binding]; other site 471853002889 putative IPP diphosphate binding site; other site 471853002890 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 471853002891 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 471853002892 putative active site [active] 471853002893 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853002894 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 471853002895 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471853002896 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471853002897 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 471853002898 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853002899 ferrochelatase; Reviewed; Region: hemH; PRK00035 471853002900 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 471853002901 C-terminal domain interface [polypeptide binding]; other site 471853002902 active site 471853002903 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 471853002904 active site 471853002905 N-terminal domain interface [polypeptide binding]; other site 471853002906 Chlorite dismutase; Region: Chlor_dismutase; cl01280 471853002907 transcriptional regulator BetI; Validated; Region: PRK00767 471853002908 Helix-turn-helix domains; Region: HTH; cl00088 471853002909 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 471853002910 Helix-turn-helix domains; Region: HTH; cl00088 471853002911 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 471853002912 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853002913 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 471853002914 active site clefts [active] 471853002915 zinc binding site [ion binding]; other site 471853002916 dimer interface [polypeptide binding]; other site 471853002917 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853002918 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853002919 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 471853002920 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853002921 dimer interface [polypeptide binding]; other site 471853002922 conserved gate region; other site 471853002923 putative PBP binding loops; other site 471853002924 ABC-ATPase subunit interface; other site 471853002925 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853002926 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853002927 dimer interface [polypeptide binding]; other site 471853002928 conserved gate region; other site 471853002929 ABC-ATPase subunit interface; other site 471853002930 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 471853002931 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 471853002932 Walker A/P-loop; other site 471853002933 ATP binding site [chemical binding]; other site 471853002934 Q-loop/lid; other site 471853002935 ABC transporter signature motif; other site 471853002936 Walker B; other site 471853002937 D-loop; other site 471853002938 H-loop/switch region; other site 471853002939 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471853002940 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 471853002941 putative substrate binding site [chemical binding]; other site 471853002942 putative ATP binding site [chemical binding]; other site 471853002943 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 471853002944 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 471853002945 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 471853002946 generic binding surface II; other site 471853002947 generic binding surface I; other site 471853002948 LytB protein; Region: LYTB; cl00507 471853002949 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 471853002950 RmuC family; Region: RmuC; pfam02646 471853002951 GTP-binding protein YchF; Reviewed; Region: PRK09601 471853002952 YchF GTPase; Region: YchF; cd01900 471853002953 G1 box; other site 471853002954 GTP/Mg2+ binding site [chemical binding]; other site 471853002955 Switch I region; other site 471853002956 G2 box; other site 471853002957 Switch II region; other site 471853002958 G3 box; other site 471853002959 G4 box; other site 471853002960 G5 box; other site 471853002961 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 471853002962 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471853002963 metal binding site [ion binding]; metal-binding site 471853002964 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853002965 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471853002966 active site 471853002967 metal binding site [ion binding]; metal-binding site 471853002968 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471853002969 active site 471853002970 metal binding site [ion binding]; metal-binding site 471853002971 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 471853002972 heme-binding site [chemical binding]; other site 471853002973 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 471853002974 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 471853002975 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471853002976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853002977 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853002978 dimer interface [polypeptide binding]; other site 471853002979 conserved gate region; other site 471853002980 putative PBP binding loops; other site 471853002981 ABC-ATPase subunit interface; other site 471853002982 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 471853002983 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471853002984 Walker A/P-loop; other site 471853002985 ATP binding site [chemical binding]; other site 471853002986 Q-loop/lid; other site 471853002987 ABC transporter signature motif; other site 471853002988 Walker B; other site 471853002989 D-loop; other site 471853002990 H-loop/switch region; other site 471853002991 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853002992 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471853002993 Walker A/P-loop; other site 471853002994 ATP binding site [chemical binding]; other site 471853002995 Q-loop/lid; other site 471853002996 ABC transporter signature motif; other site 471853002997 Walker B; other site 471853002998 D-loop; other site 471853002999 H-loop/switch region; other site 471853003000 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853003001 BCCT family transporter; Region: BCCT; cl00569 471853003002 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 471853003003 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 471853003004 G1 box; other site 471853003005 putative GEF interaction site [polypeptide binding]; other site 471853003006 GTP/Mg2+ binding site [chemical binding]; other site 471853003007 Switch I region; other site 471853003008 G2 box; other site 471853003009 G3 box; other site 471853003010 Switch II region; other site 471853003011 G4 box; other site 471853003012 G5 box; other site 471853003013 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 471853003014 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 471853003015 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 471853003016 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 471853003017 VanW like protein; Region: VanW; pfam04294 471853003018 Ferredoxin [Energy production and conversion]; Region: COG1146 471853003019 4Fe-4S binding domain; Region: Fer4; cl02805 471853003020 succinyldiaminopimelate transaminase; Region: DapC_actino; TIGR03539 471853003021 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471853003022 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853003023 homodimer interface [polypeptide binding]; other site 471853003024 catalytic residue [active] 471853003025 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 471853003026 dimer interface [polypeptide binding]; other site 471853003027 Citrate synthase; Region: Citrate_synt; pfam00285 471853003028 active site 471853003029 citrylCoA binding site [chemical binding]; other site 471853003030 NADH binding [chemical binding]; other site 471853003031 cationic pore residues; other site 471853003032 oxalacetate/citrate binding site [chemical binding]; other site 471853003033 coenzyme A binding site [chemical binding]; other site 471853003034 catalytic triad [active] 471853003035 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 471853003036 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 471853003037 putative trimer interface [polypeptide binding]; other site 471853003038 putative CoA binding site [chemical binding]; other site 471853003039 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 471853003040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853003041 Cupin domain; Region: Cupin_2; cl09118 471853003042 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853003043 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471853003044 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853003045 META domain; Region: META; cl01245 471853003046 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 471853003047 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 471853003048 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 471853003049 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471853003050 ATP-grasp domain; Region: ATP-grasp_4; cl03087 471853003051 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 471853003052 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 471853003053 carboxyltransferase (CT) interaction site; other site 471853003054 biotinylation site [posttranslational modification]; other site 471853003055 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853003056 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471853003057 active site 471853003058 metal binding site [ion binding]; metal-binding site 471853003059 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471853003060 active site 471853003061 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853003062 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853003063 Coenzyme A binding pocket [chemical binding]; other site 471853003064 Maf-like protein; Region: Maf; pfam02545 471853003065 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 471853003066 active site 471853003067 dimer interface [polypeptide binding]; other site 471853003068 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 471853003069 nudix motif; other site 471853003070 Helix-turn-helix domains; Region: HTH; cl00088 471853003071 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853003072 NAD(P) binding site [chemical binding]; other site 471853003073 active site 471853003074 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 471853003075 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 471853003076 conserved cys residue [active] 471853003077 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853003078 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853003079 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 471853003080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853003081 NAD(P) binding site [chemical binding]; other site 471853003082 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 471853003083 active site 471853003084 Helix-turn-helix domains; Region: HTH; cl00088 471853003085 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 471853003086 substrate binding site [chemical binding]; other site 471853003087 dimer interface [polypeptide binding]; other site 471853003088 ATP binding site [chemical binding]; other site 471853003089 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 471853003090 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 471853003091 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 471853003092 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 471853003093 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 471853003094 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 471853003095 cyclase homology domain; Region: CHD; cd07302 471853003096 nucleotidyl binding site; other site 471853003097 metal binding site [ion binding]; metal-binding site 471853003098 dimer interface [polypeptide binding]; other site 471853003099 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471853003100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853003101 active site 471853003102 phosphorylation site [posttranslational modification] 471853003103 intermolecular recognition site; other site 471853003104 dimerization interface [polypeptide binding]; other site 471853003105 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471853003106 DNA binding site [nucleotide binding] 471853003107 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 471853003108 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471853003109 phosphorylation site [posttranslational modification] 471853003110 dimer interface [polypeptide binding]; other site 471853003111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471853003112 ATP binding site [chemical binding]; other site 471853003113 Mg2+ binding site [ion binding]; other site 471853003114 G-X-G motif; other site 471853003115 GtrA-like protein; Region: GtrA; cl00971 471853003116 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 471853003117 ATP-grasp domain; Region: ATP-grasp_4; cl03087 471853003118 AIR carboxylase; Region: AIRC; cl00310 471853003119 OpgC protein; Region: OpgC_C; cl00792 471853003120 Acyltransferase family; Region: Acyl_transf_3; pfam01757 471853003121 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471853003122 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 471853003123 active site 471853003124 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 471853003125 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 471853003126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853003127 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 471853003128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853003129 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853003130 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 471853003131 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 471853003132 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 471853003133 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853003134 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 471853003135 NAD(P) binding site [chemical binding]; other site 471853003136 active site 471853003137 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471853003138 active site 471853003139 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471853003140 active site 471853003141 OpgC protein; Region: OpgC_C; cl00792 471853003142 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 471853003143 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853003144 UDP-galactopyranose mutase; Region: GLF; pfam03275 471853003145 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 471853003146 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 471853003147 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 471853003148 active site 471853003149 metal-binding site 471853003150 LicD family; Region: LicD; cl01378 471853003151 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 471853003152 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 471853003153 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 471853003154 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471853003155 active site 471853003156 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 471853003157 Stage II sporulation protein; Region: SpoIID; pfam08486 471853003158 Family description; Region: VCBS; pfam13517 471853003159 Family description; Region: VCBS; pfam13517 471853003160 Family description; Region: VCBS; pfam13517 471853003161 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 471853003162 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 471853003163 inhibitor-cofactor binding pocket; inhibition site 471853003164 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853003165 catalytic residue [active] 471853003166 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 471853003167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853003168 NAD(P) binding site [chemical binding]; other site 471853003169 active site 471853003170 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 471853003171 trimer interface [polypeptide binding]; other site 471853003172 active site 471853003173 substrate binding site [chemical binding]; other site 471853003174 CoA binding site [chemical binding]; other site 471853003175 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853003176 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853003177 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 471853003178 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 471853003179 inhibitor-cofactor binding pocket; inhibition site 471853003180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853003181 catalytic residue [active] 471853003182 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 471853003183 putative trimer interface [polypeptide binding]; other site 471853003184 putative CoA binding site [chemical binding]; other site 471853003185 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 471853003186 hydroxyglutarate oxidase; Provisional; Region: PRK11728 471853003187 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853003188 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 471853003189 amidase catalytic site [active] 471853003190 Zn binding residues [ion binding]; other site 471853003191 substrate binding site [chemical binding]; other site 471853003192 Family description; Region: VCBS; pfam13517 471853003193 Family description; Region: VCBS; pfam13517 471853003194 Family description; Region: VCBS; pfam13517 471853003195 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 471853003196 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 471853003197 NAD binding site [chemical binding]; other site 471853003198 substrate binding site [chemical binding]; other site 471853003199 homodimer interface [polypeptide binding]; other site 471853003200 active site 471853003201 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 471853003202 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 471853003203 substrate binding site; other site 471853003204 tetramer interface; other site 471853003205 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 471853003206 trimer interface [polypeptide binding]; other site 471853003207 active site 471853003208 substrate binding site [chemical binding]; other site 471853003209 CoA binding site [chemical binding]; other site 471853003210 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 471853003211 active site 471853003212 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 471853003213 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 471853003214 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 471853003215 active site 471853003216 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 471853003217 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853003218 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 471853003219 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471853003220 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471853003221 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 471853003222 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 471853003223 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853003224 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 471853003225 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 471853003226 homodimer interface [polypeptide binding]; other site 471853003227 active site 471853003228 putative glycosyl transferase; Provisional; Region: PRK10073 471853003229 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 471853003230 active site 471853003231 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853003232 NAD(P) binding site [chemical binding]; other site 471853003233 active site 471853003234 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 471853003235 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 471853003236 active site 471853003237 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 471853003238 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471853003239 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853003240 S-adenosylmethionine binding site [chemical binding]; other site 471853003241 LicD family; Region: LicD; cl01378 471853003242 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853003243 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853003244 AMP-binding enzyme; Region: AMP-binding; cl15778 471853003245 Transcription factor WhiB; Region: Whib; pfam02467 471853003246 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471853003247 mycofactocin system glycosyltransferase; Region: actino_glycTran; TIGR03965 471853003248 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 471853003249 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 471853003250 NADP binding site [chemical binding]; other site 471853003251 active site 471853003252 putative substrate binding site [chemical binding]; other site 471853003253 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 471853003254 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853003255 dimerization interface [polypeptide binding]; other site 471853003256 putative DNA binding site [nucleotide binding]; other site 471853003257 putative Zn2+ binding site [ion binding]; other site 471853003258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853003259 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 471853003260 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 471853003261 active site 471853003262 dimer interface [polypeptide binding]; other site 471853003263 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 471853003264 motif 1; other site 471853003265 motif 2; other site 471853003266 motif 3; other site 471853003267 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 471853003268 anticodon binding site; other site 471853003269 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 471853003270 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 471853003271 active site 471853003272 catalytic site [active] 471853003273 Trm112p-like protein; Region: Trm112p; cl01066 471853003274 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 471853003275 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471853003276 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471853003277 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 471853003278 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 471853003279 Walker A/P-loop; other site 471853003280 ATP binding site [chemical binding]; other site 471853003281 Q-loop/lid; other site 471853003282 ABC transporter signature motif; other site 471853003283 Walker B; other site 471853003284 D-loop; other site 471853003285 H-loop/switch region; other site 471853003286 Cation efflux family; Region: Cation_efflux; cl00316 471853003287 Cupin domain; Region: Cupin_2; cl09118 471853003288 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853003289 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471853003290 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 471853003291 NMT1-like family; Region: NMT1_2; cl15260 471853003292 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 471853003293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853003294 dimer interface [polypeptide binding]; other site 471853003295 conserved gate region; other site 471853003296 putative PBP binding loops; other site 471853003297 ABC-ATPase subunit interface; other site 471853003298 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 471853003299 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 471853003300 Walker A/P-loop; other site 471853003301 ATP binding site [chemical binding]; other site 471853003302 Q-loop/lid; other site 471853003303 ABC transporter signature motif; other site 471853003304 Walker B; other site 471853003305 D-loop; other site 471853003306 H-loop/switch region; other site 471853003307 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 471853003308 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 471853003309 active site 471853003310 substrate binding site [chemical binding]; other site 471853003311 ATP binding site [chemical binding]; other site 471853003312 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 471853003313 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 471853003314 dimer interface [polypeptide binding]; other site 471853003315 putative functional site; other site 471853003316 putative MPT binding site; other site 471853003317 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 471853003318 DNA binding residues [nucleotide binding] 471853003319 TOBE domain; Region: TOBE_2; cl01440 471853003320 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 471853003321 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853003322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853003323 dimer interface [polypeptide binding]; other site 471853003324 conserved gate region; other site 471853003325 putative PBP binding loops; other site 471853003326 ABC-ATPase subunit interface; other site 471853003327 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 471853003328 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853003329 Walker A/P-loop; other site 471853003330 ATP binding site [chemical binding]; other site 471853003331 Q-loop/lid; other site 471853003332 ABC transporter signature motif; other site 471853003333 Walker B; other site 471853003334 D-loop; other site 471853003335 H-loop/switch region; other site 471853003336 TOBE domain; Region: TOBE_2; cl01440 471853003337 Adenosylhomocysteinase; Provisional; Region: PTZ00075 471853003338 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401 471853003339 oligomerization interface [polypeptide binding]; other site 471853003340 active site 471853003341 NAD+ binding site [chemical binding]; other site 471853003342 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853003343 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 471853003344 Walker A/P-loop; other site 471853003345 ATP binding site [chemical binding]; other site 471853003346 Q-loop/lid; other site 471853003347 ABC transporter signature motif; other site 471853003348 Walker B; other site 471853003349 D-loop; other site 471853003350 H-loop/switch region; other site 471853003351 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471853003352 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 471853003353 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 471853003354 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 471853003355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853003356 active site 471853003357 phosphorylation site [posttranslational modification] 471853003358 intermolecular recognition site; other site 471853003359 dimerization interface [polypeptide binding]; other site 471853003360 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471853003361 DNA binding site [nucleotide binding] 471853003362 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471853003363 dimerization interface [polypeptide binding]; other site 471853003364 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471853003365 dimer interface [polypeptide binding]; other site 471853003366 phosphorylation site [posttranslational modification] 471853003367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471853003368 lipoprotein LpqB; Provisional; Region: PRK13614 471853003369 Sporulation and spore germination; Region: Germane; cl11253 471853003370 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 471853003371 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 471853003372 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 471853003373 30S subunit binding site; other site 471853003374 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 471853003375 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 471853003376 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853003377 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 471853003378 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471853003379 nucleotide binding region [chemical binding]; other site 471853003380 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853003381 Predicted ATPase [General function prediction only]; Region: COG3899 471853003382 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853003383 DNA binding residues [nucleotide binding] 471853003384 dimerization interface [polypeptide binding]; other site 471853003385 Domain of unknown function DUF87; Region: DUF87; pfam01935 471853003386 AAA-like domain; Region: AAA_10; pfam12846 471853003387 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 471853003388 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 471853003389 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 471853003390 putative ligand binding site [chemical binding]; other site 471853003391 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 471853003392 Ca binding site [ion binding]; other site 471853003393 carbohydrate binding site [chemical binding]; other site 471853003394 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 471853003395 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471853003396 SAF domain; Region: SAF; cl00555 471853003397 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 471853003398 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 471853003399 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853003400 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 471853003401 active site 471853003402 Predicted GTPases [General function prediction only]; Region: COG1162 471853003403 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 471853003404 GTPase/Zn-binding domain interface [polypeptide binding]; other site 471853003405 GTP/Mg2+ binding site [chemical binding]; other site 471853003406 G4 box; other site 471853003407 G5 box; other site 471853003408 G1 box; other site 471853003409 Switch I region; other site 471853003410 G2 box; other site 471853003411 G3 box; other site 471853003412 Switch II region; other site 471853003413 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 471853003414 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 471853003415 hinge; other site 471853003416 active site 471853003417 DoxX; Region: DoxX; cl00976 471853003418 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 471853003419 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853003420 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471853003421 DNA binding residues [nucleotide binding] 471853003422 Putative zinc-finger; Region: zf-HC2; cl15806 471853003423 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853003424 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471853003425 NAD(P) binding site [chemical binding]; other site 471853003426 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 471853003427 active site 471853003428 catalytic triad [active] 471853003429 oxyanion hole [active] 471853003430 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 471853003431 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 471853003432 conserved cys residue [active] 471853003433 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853003434 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 471853003435 transcriptional regulator NarP; Provisional; Region: PRK10403 471853003436 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853003437 DNA binding residues [nucleotide binding] 471853003438 dimerization interface [polypeptide binding]; other site 471853003439 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 471853003440 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 471853003441 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; Region: SucA; COG0567 471853003442 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 471853003443 TPP-binding site [chemical binding]; other site 471853003444 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 471853003445 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471853003446 dimerization interface [polypeptide binding]; other site 471853003447 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471853003448 dimer interface [polypeptide binding]; other site 471853003449 phosphorylation site [posttranslational modification] 471853003450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471853003451 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471853003452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853003453 active site 471853003454 phosphorylation site [posttranslational modification] 471853003455 intermolecular recognition site; other site 471853003456 dimerization interface [polypeptide binding]; other site 471853003457 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471853003458 DNA binding site [nucleotide binding] 471853003459 hypothetical protein; Region: PHA02030 471853003460 Peptidase family M23; Region: Peptidase_M23; pfam01551 471853003461 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 471853003462 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 471853003463 active site 471853003464 catalytic residues [active] 471853003465 diaminopimelate decarboxylase; Region: lysA; TIGR01048 471853003466 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 471853003467 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471853003468 catalytic residue [active] 471853003469 homoserine dehydrogenase; Provisional; Region: PRK06349 471853003470 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853003471 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 471853003472 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 471853003473 threonine synthase; Reviewed; Region: PRK06721 471853003474 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 471853003475 homodimer interface [polypeptide binding]; other site 471853003476 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853003477 catalytic residue [active] 471853003478 homoserine kinase; Provisional; Region: PRK01212 471853003479 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 471853003480 transcription termination factor Rho; Provisional; Region: PRK12608 471853003481 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 471853003482 RNA binding site [nucleotide binding]; other site 471853003483 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853003484 Walker A motif; other site 471853003485 ATP binding site [chemical binding]; other site 471853003486 Walker B motif; other site 471853003487 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 471853003488 RF-1 domain; Region: RF-1; cl02875 471853003489 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 471853003490 RF-1 domain; Region: RF-1; cl02875 471853003491 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 471853003492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853003493 S-adenosylmethionine binding site [chemical binding]; other site 471853003494 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 471853003495 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 471853003496 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 471853003497 Mg++ binding site [ion binding]; other site 471853003498 putative catalytic motif [active] 471853003499 substrate binding site [chemical binding]; other site 471853003500 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 471853003501 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 471853003502 active site 471853003503 PhoD-like phosphatase; Region: PhoD; pfam09423 471853003504 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 471853003505 putative active site [active] 471853003506 putative metal binding site [ion binding]; other site 471853003507 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853003508 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853003509 DNA binding site [nucleotide binding] 471853003510 domain linker motif; other site 471853003511 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853003512 ligand binding site [chemical binding]; other site 471853003513 dimerization interface [polypeptide binding]; other site 471853003514 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 471853003515 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853003516 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 471853003517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853003518 dimer interface [polypeptide binding]; other site 471853003519 conserved gate region; other site 471853003520 putative PBP binding loops; other site 471853003521 ABC-ATPase subunit interface; other site 471853003522 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853003523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853003524 dimer interface [polypeptide binding]; other site 471853003525 conserved gate region; other site 471853003526 putative PBP binding loops; other site 471853003527 ABC-ATPase subunit interface; other site 471853003528 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 471853003529 Sulfatase; Region: Sulfatase; cl10460 471853003530 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471853003531 ATP synthase A chain; Region: ATP-synt_A; cl00413 471853003532 ATP synthase subunit C; Region: ATP-synt_C; cl00466 471853003533 Plant ATP synthase F0; Region: YMF19; cl07975 471853003534 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 471853003535 Plant ATP synthase F0; Region: YMF19; cl07975 471853003536 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 471853003537 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 471853003538 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 471853003539 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 471853003540 beta subunit interaction interface [polypeptide binding]; other site 471853003541 Walker A motif; other site 471853003542 ATP binding site [chemical binding]; other site 471853003543 Walker B motif; other site 471853003544 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 471853003545 ATP synthase; Region: ATP-synt; cl00365 471853003546 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 471853003547 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 471853003548 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 471853003549 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 471853003550 alpha subunit interaction interface [polypeptide binding]; other site 471853003551 Walker A motif; other site 471853003552 ATP binding site [chemical binding]; other site 471853003553 Walker B motif; other site 471853003554 inhibitor binding site; inhibition site 471853003555 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 471853003556 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 471853003557 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 471853003558 Protein of unknown function DUF91; Region: DUF91; cl00709 471853003559 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853003560 Helix-turn-helix domains; Region: HTH; cl00088 471853003561 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 471853003562 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471853003563 active site 471853003564 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 471853003565 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 471853003566 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 471853003567 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 471853003568 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853003569 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853003570 DNA binding site [nucleotide binding] 471853003571 domain linker motif; other site 471853003572 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853003573 dimerization interface [polypeptide binding]; other site 471853003574 ligand binding site [chemical binding]; other site 471853003575 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 471853003576 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 471853003577 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 471853003578 Fibronectin type III-like domain; Region: Fn3-like; cl15273 471853003579 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853003580 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853003581 dimer interface [polypeptide binding]; other site 471853003582 conserved gate region; other site 471853003583 ABC-ATPase subunit interface; other site 471853003584 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853003585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853003586 dimer interface [polypeptide binding]; other site 471853003587 conserved gate region; other site 471853003588 putative PBP binding loops; other site 471853003589 ABC-ATPase subunit interface; other site 471853003590 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853003591 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853003592 DNA binding site [nucleotide binding] 471853003593 domain linker motif; other site 471853003594 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853003595 dimerization interface [polypeptide binding]; other site 471853003596 ligand binding site [chemical binding]; other site 471853003597 putative alpha-glucosidase; Provisional; Region: PRK10658 471853003598 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 471853003599 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 471853003600 active site 471853003601 homotrimer interface [polypeptide binding]; other site 471853003602 catalytic site [active] 471853003603 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 471853003604 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471853003605 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853003606 Walker A/P-loop; other site 471853003607 ATP binding site [chemical binding]; other site 471853003608 Q-loop/lid; other site 471853003609 ABC transporter signature motif; other site 471853003610 Walker B; other site 471853003611 D-loop; other site 471853003612 H-loop/switch region; other site 471853003613 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 471853003614 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853003615 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853003616 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 471853003617 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 471853003618 glycogen branching enzyme; Provisional; Region: PRK05402 471853003619 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 471853003620 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 471853003621 active site 471853003622 catalytic site [active] 471853003623 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 471853003624 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 471853003625 trehalose synthase; Region: treS_nterm; TIGR02456 471853003626 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 471853003627 active site 471853003628 catalytic site [active] 471853003629 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 471853003630 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 471853003631 active site 471853003632 homodimer interface [polypeptide binding]; other site 471853003633 catalytic site [active] 471853003634 acceptor binding site [chemical binding]; other site 471853003635 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 471853003636 putative homodimer interface [polypeptide binding]; other site 471853003637 putative active site pocket [active] 471853003638 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 471853003639 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 471853003640 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 471853003641 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 471853003642 active site 471853003643 HIGH motif; other site 471853003644 dimer interface [polypeptide binding]; other site 471853003645 KMSKS motif; other site 471853003646 RDD family; Region: RDD; cl00746 471853003647 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 471853003648 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853003649 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 471853003650 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 471853003651 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 471853003652 active site 471853003653 catalytic site [active] 471853003654 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 471853003655 Ligand binding site [chemical binding]; other site 471853003656 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 471853003657 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 471853003658 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 471853003659 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 471853003660 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 471853003661 putative active site [active] 471853003662 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471853003663 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471853003664 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 471853003665 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 471853003666 Walker A/P-loop; other site 471853003667 ATP binding site [chemical binding]; other site 471853003668 Q-loop/lid; other site 471853003669 ABC transporter signature motif; other site 471853003670 Walker B; other site 471853003671 D-loop; other site 471853003672 H-loop/switch region; other site 471853003673 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 471853003674 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 471853003675 TM-ABC transporter signature motif; other site 471853003676 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 471853003677 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 471853003678 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853003679 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853003680 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 471853003681 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471853003682 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 471853003683 Metal-binding active site; metal-binding site 471853003684 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 471853003685 Phosphotransferase enzyme family; Region: APH; pfam01636 471853003686 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471853003687 active site 471853003688 ATP binding site [chemical binding]; other site 471853003689 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853003690 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 471853003691 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853003692 DNA binding residues [nucleotide binding] 471853003693 Putative sensor; Region: Sensor; pfam13796 471853003694 Histidine kinase; Region: HisKA_3; pfam07730 471853003695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471853003696 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471853003697 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 471853003698 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471853003699 catalytic residue [active] 471853003700 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853003701 NAD(P) binding site [chemical binding]; other site 471853003702 active site 471853003703 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 471853003704 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 471853003705 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 471853003706 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471853003707 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 471853003708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853003709 putative substrate translocation pore; other site 471853003710 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 471853003711 Helix-turn-helix domains; Region: HTH; cl00088 471853003712 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 471853003713 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 471853003714 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 471853003715 nucleotide binding pocket [chemical binding]; other site 471853003716 K-X-D-G motif; other site 471853003717 catalytic site [active] 471853003718 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 471853003719 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 471853003720 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 471853003721 Dimer interface [polypeptide binding]; other site 471853003722 LamB/YcsF family; Region: LamB_YcsF; cl00664 471853003723 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 471853003724 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 471853003725 uridine kinase; Validated; Region: PRK06696 471853003726 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 471853003727 glycosyltransferase, MGT family; Region: MGT; TIGR01426 471853003728 active site 471853003729 TDP-binding site; other site 471853003730 acceptor substrate-binding pocket; other site 471853003731 Helix-turn-helix domains; Region: HTH; cl00088 471853003732 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 471853003733 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 471853003734 Amidase; Region: Amidase; cl11426 471853003735 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 471853003736 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 471853003737 GatB domain; Region: GatB_Yqey; cl11497 471853003738 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471853003739 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853003740 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 471853003741 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 471853003742 metal binding site [ion binding]; metal-binding site 471853003743 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 471853003744 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 471853003745 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471853003746 ABC-ATPase subunit interface; other site 471853003747 dimer interface [polypeptide binding]; other site 471853003748 putative PBP binding regions; other site 471853003749 Helix-turn-helix domains; Region: HTH; cl00088 471853003750 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 471853003751 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 471853003752 FeoA domain; Region: FeoA; cl00838 471853003753 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 471853003754 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 471853003755 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 471853003756 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 471853003757 putative active site [active] 471853003758 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 471853003759 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853003760 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 471853003761 substrate binding site [chemical binding]; other site 471853003762 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471853003763 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 471853003764 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471853003765 substrate binding site [chemical binding]; other site 471853003766 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471853003767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853003768 dimer interface [polypeptide binding]; other site 471853003769 conserved gate region; other site 471853003770 putative PBP binding loops; other site 471853003771 ABC-ATPase subunit interface; other site 471853003772 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 471853003773 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 471853003774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853003775 dimer interface [polypeptide binding]; other site 471853003776 conserved gate region; other site 471853003777 putative PBP binding loops; other site 471853003778 ABC-ATPase subunit interface; other site 471853003779 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 471853003780 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471853003781 Walker A/P-loop; other site 471853003782 ATP binding site [chemical binding]; other site 471853003783 Q-loop/lid; other site 471853003784 ABC transporter signature motif; other site 471853003785 Walker B; other site 471853003786 D-loop; other site 471853003787 H-loop/switch region; other site 471853003788 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853003789 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 471853003790 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471853003791 Walker A/P-loop; other site 471853003792 ATP binding site [chemical binding]; other site 471853003793 Q-loop/lid; other site 471853003794 ABC transporter signature motif; other site 471853003795 Walker B; other site 471853003796 D-loop; other site 471853003797 H-loop/switch region; other site 471853003798 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853003799 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 471853003800 Dehydratase family; Region: ILVD_EDD; cl00340 471853003801 Dehydratase family; Region: ILVD_EDD; cl00340 471853003802 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 471853003803 aromatic arch; other site 471853003804 DCoH dimer interaction site [polypeptide binding]; other site 471853003805 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 471853003806 DCoH tetramer interaction site [polypeptide binding]; other site 471853003807 substrate binding site [chemical binding]; other site 471853003808 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 471853003809 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 471853003810 PYR/PP interface [polypeptide binding]; other site 471853003811 dimer interface [polypeptide binding]; other site 471853003812 TPP binding site [chemical binding]; other site 471853003813 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 471853003814 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 471853003815 TPP-binding site [chemical binding]; other site 471853003816 dimer interface [polypeptide binding]; other site 471853003817 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 471853003818 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 471853003819 putative valine binding site [chemical binding]; other site 471853003820 dimer interface [polypeptide binding]; other site 471853003821 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 471853003822 ketol-acid reductoisomerase; Provisional; Region: PRK05479 471853003823 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853003824 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 471853003825 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 471853003826 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 471853003827 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 471853003828 minor groove reading motif; other site 471853003829 helix-hairpin-helix signature motif; other site 471853003830 substrate binding pocket [chemical binding]; other site 471853003831 active site 471853003832 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 471853003833 active site 471853003834 catalytic residues [active] 471853003835 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 471853003836 Strictosidine synthase; Region: Str_synth; pfam03088 471853003837 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 471853003838 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 471853003839 tartrate dehydrogenase; Provisional; Region: PRK08194 471853003840 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 471853003841 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 471853003842 homodimer interface [polypeptide binding]; other site 471853003843 substrate-cofactor binding pocket; other site 471853003844 catalytic residue [active] 471853003845 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 471853003846 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471853003847 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 471853003848 Helix-turn-helix domains; Region: HTH; cl00088 471853003849 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 471853003850 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 471853003851 active site 471853003852 catalytic residues [active] 471853003853 metal binding site [ion binding]; metal-binding site 471853003854 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 471853003855 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 471853003856 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471853003857 non-specific DNA binding site [nucleotide binding]; other site 471853003858 salt bridge; other site 471853003859 sequence-specific DNA binding site [nucleotide binding]; other site 471853003860 Cupin domain; Region: Cupin_2; cl09118 471853003861 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 471853003862 Protein of unknown function (DUF419); Region: DUF419; cl15265 471853003863 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 471853003864 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 471853003865 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 471853003866 minor groove reading motif; other site 471853003867 helix-hairpin-helix signature motif; other site 471853003868 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471853003869 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 471853003870 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471853003871 catalytic residue [active] 471853003872 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 471853003873 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 471853003874 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853003875 DNA-binding site [nucleotide binding]; DNA binding site 471853003876 FCD domain; Region: FCD; cl11656 471853003877 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 471853003878 inhibitor site; inhibition site 471853003879 active site 471853003880 dimer interface [polypeptide binding]; other site 471853003881 catalytic residue [active] 471853003882 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 471853003883 catalytic site [active] 471853003884 BNR repeat-like domain; Region: BNR_2; pfam13088 471853003885 Asp-box motif; other site 471853003886 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853003887 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853003888 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853003889 dimer interface [polypeptide binding]; other site 471853003890 conserved gate region; other site 471853003891 ABC-ATPase subunit interface; other site 471853003892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853003893 dimer interface [polypeptide binding]; other site 471853003894 conserved gate region; other site 471853003895 putative PBP binding loops; other site 471853003896 ABC-ATPase subunit interface; other site 471853003897 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 471853003898 catalytic site [active] 471853003899 BNR repeat-like domain; Region: BNR_2; pfam13088 471853003900 Asp-box motif; other site 471853003901 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 471853003902 putative deacylase active site [active] 471853003903 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 471853003904 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 471853003905 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853003906 ski2-like helicase; Provisional; Region: PRK02362 471853003907 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471853003908 nucleotide binding region [chemical binding]; other site 471853003909 ATP-binding site [chemical binding]; other site 471853003910 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 471853003911 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471853003912 DNA binding residues [nucleotide binding] 471853003913 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 471853003914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 471853003915 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 471853003916 Transcriptional regulators [Transcription]; Region: GntR; COG1802 471853003917 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853003918 DNA-binding site [nucleotide binding]; DNA binding site 471853003919 FCD domain; Region: FCD; cl11656 471853003920 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 471853003921 nucleoside/Zn binding site; other site 471853003922 dimer interface [polypeptide binding]; other site 471853003923 catalytic motif [active] 471853003924 cytosine deaminase; Provisional; Region: PRK05985 471853003925 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 471853003926 active site 471853003927 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 471853003928 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 471853003929 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853003930 NAD(P) binding site [chemical binding]; other site 471853003931 active site 471853003932 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853003933 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853003934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853003935 dimer interface [polypeptide binding]; other site 471853003936 conserved gate region; other site 471853003937 putative PBP binding loops; other site 471853003938 ABC-ATPase subunit interface; other site 471853003939 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853003940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853003941 dimer interface [polypeptide binding]; other site 471853003942 conserved gate region; other site 471853003943 ABC-ATPase subunit interface; other site 471853003944 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 471853003945 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 471853003946 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 471853003947 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 471853003948 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471853003949 inhibitor-cofactor binding pocket; inhibition site 471853003950 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853003951 catalytic residue [active] 471853003952 Uncharacterized conserved protein [Function unknown]; Region: COG5476 471853003953 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 471853003954 MlrC C-terminus; Region: MlrC_C; pfam07171 471853003955 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 471853003956 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 471853003957 active site pocket [active] 471853003958 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 471853003959 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471853003960 active site 471853003961 metal binding site [ion binding]; metal-binding site 471853003962 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 471853003963 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471853003964 Helix-turn-helix domains; Region: HTH; cl00088 471853003965 Bacterial transcriptional regulator; Region: IclR; pfam01614 471853003966 H+ Antiporter protein; Region: 2A0121; TIGR00900 471853003967 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 471853003968 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471853003969 ATP binding site [chemical binding]; other site 471853003970 putative Mg++ binding site [ion binding]; other site 471853003971 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471853003972 nucleotide binding region [chemical binding]; other site 471853003973 ATP-binding site [chemical binding]; other site 471853003974 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853003975 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853003976 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853003977 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853003978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853003979 putative PBP binding loops; other site 471853003980 dimer interface [polypeptide binding]; other site 471853003981 ABC-ATPase subunit interface; other site 471853003982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853003983 dimer interface [polypeptide binding]; other site 471853003984 conserved gate region; other site 471853003985 putative PBP binding loops; other site 471853003986 ABC-ATPase subunit interface; other site 471853003987 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 471853003988 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 471853003989 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853003990 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853003991 DNA binding site [nucleotide binding] 471853003992 domain linker motif; other site 471853003993 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853003994 ligand binding site [chemical binding]; other site 471853003995 dimerization interface [polypeptide binding]; other site 471853003996 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 471853003997 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 471853003998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 471853003999 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 471853004000 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 471853004001 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 471853004002 active site 471853004003 catalytic site [active] 471853004004 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 471853004005 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 471853004006 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 471853004007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004008 putative PBP binding loops; other site 471853004009 dimer interface [polypeptide binding]; other site 471853004010 ABC-ATPase subunit interface; other site 471853004011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004012 dimer interface [polypeptide binding]; other site 471853004013 conserved gate region; other site 471853004014 putative PBP binding loops; other site 471853004015 ABC-ATPase subunit interface; other site 471853004016 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 471853004017 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853004018 short chain dehydrogenase; Provisional; Region: PRK06138 471853004019 classical (c) SDRs; Region: SDR_c; cd05233 471853004020 NAD(P) binding site [chemical binding]; other site 471853004021 active site 471853004022 enolase; Provisional; Region: eno; PRK00077 471853004023 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 471853004024 dimer interface [polypeptide binding]; other site 471853004025 metal binding site [ion binding]; metal-binding site 471853004026 substrate binding pocket [chemical binding]; other site 471853004027 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471853004028 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 471853004029 substrate binding site [chemical binding]; other site 471853004030 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 471853004031 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 471853004032 putative NAD(P) binding site [chemical binding]; other site 471853004033 catalytic Zn binding site [ion binding]; other site 471853004034 Dehydratase family; Region: ILVD_EDD; cl00340 471853004035 Helix-turn-helix domains; Region: HTH; cl00088 471853004036 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471853004037 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471853004038 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 471853004039 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 471853004040 Protein of unknown function DUF91; Region: DUF91; cl00709 471853004041 HsdM N-terminal domain; Region: HsdM_N; pfam12161 471853004042 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 471853004043 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853004044 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 471853004045 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 471853004046 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 471853004047 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 471853004048 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 471853004049 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471853004050 ATP binding site [chemical binding]; other site 471853004051 putative Mg++ binding site [ion binding]; other site 471853004052 TIR domain; Region: TIR_2; cl15770 471853004053 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 471853004054 nucleotide binding site/active site [active] 471853004055 HIT family signature motif; other site 471853004056 catalytic residue [active] 471853004057 Protein of unknown function DUF262; Region: DUF262; cl14890 471853004058 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 471853004059 Right handed beta helix region; Region: Beta_helix; pfam13229 471853004060 PhoD-like phosphatase; Region: PhoD; pfam09423 471853004061 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 471853004062 putative active site [active] 471853004063 putative metal binding site [ion binding]; other site 471853004064 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 471853004065 active site 471853004066 metal binding site [ion binding]; metal-binding site 471853004067 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 471853004068 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 471853004069 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853004070 active site 471853004071 motif I; other site 471853004072 motif II; other site 471853004073 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853004074 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 471853004075 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853004076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004077 dimer interface [polypeptide binding]; other site 471853004078 putative PBP binding loops; other site 471853004079 ABC-ATPase subunit interface; other site 471853004080 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853004081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004082 dimer interface [polypeptide binding]; other site 471853004083 conserved gate region; other site 471853004084 putative PBP binding loops; other site 471853004085 ABC-ATPase subunit interface; other site 471853004086 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853004087 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 471853004088 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 471853004089 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 471853004090 active site 471853004091 catalytic site [active] 471853004092 Carbohydrate kinase and ribulose-phosphate 3-epimerase fusion proteins-like; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CarbK-RPE_like; cd07783 471853004093 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 471853004094 N- and C-terminal domain interface [polypeptide binding]; other site 471853004095 putative active site [active] 471853004096 putative MgATP binding site [chemical binding]; other site 471853004097 catalytic site [active] 471853004098 metal binding site [ion binding]; metal-binding site 471853004099 putative carbohydrate binding site [chemical binding]; other site 471853004100 putative homodimer interface [polypeptide binding]; other site 471853004101 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 471853004102 Helix-turn-helix domains; Region: HTH; cl00088 471853004103 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 471853004104 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 471853004105 inhibitor site; inhibition site 471853004106 active site 471853004107 dimer interface [polypeptide binding]; other site 471853004108 catalytic residue [active] 471853004109 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl01922 471853004110 catalytic site [active] 471853004111 Asp-box motif; other site 471853004112 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853004113 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853004114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004115 dimer interface [polypeptide binding]; other site 471853004116 conserved gate region; other site 471853004117 putative PBP binding loops; other site 471853004118 ABC-ATPase subunit interface; other site 471853004119 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853004120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004121 dimer interface [polypeptide binding]; other site 471853004122 conserved gate region; other site 471853004123 putative PBP binding loops; other site 471853004124 ABC-ATPase subunit interface; other site 471853004125 Transcriptional regulators [Transcription]; Region: GntR; COG1802 471853004126 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853004127 DNA-binding site [nucleotide binding]; DNA binding site 471853004128 FCD domain; Region: FCD; cl11656 471853004129 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471853004130 Helix-turn-helix domains; Region: HTH; cl00088 471853004131 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853004132 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853004133 DNA binding site [nucleotide binding] 471853004134 domain linker motif; other site 471853004135 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853004136 dimerization interface [polypeptide binding]; other site 471853004137 ligand binding site [chemical binding]; other site 471853004138 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 471853004139 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853004140 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853004141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853004142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004143 dimer interface [polypeptide binding]; other site 471853004144 conserved gate region; other site 471853004145 putative PBP binding loops; other site 471853004146 ABC-ATPase subunit interface; other site 471853004147 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471853004148 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853004149 Walker A/P-loop; other site 471853004150 ATP binding site [chemical binding]; other site 471853004151 Q-loop/lid; other site 471853004152 ABC transporter signature motif; other site 471853004153 Walker B; other site 471853004154 D-loop; other site 471853004155 H-loop/switch region; other site 471853004156 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853004157 Q-loop/lid; other site 471853004158 ABC transporter signature motif; other site 471853004159 Sulfatase; Region: Sulfatase; cl10460 471853004160 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853004161 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853004162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004163 dimer interface [polypeptide binding]; other site 471853004164 conserved gate region; other site 471853004165 putative PBP binding loops; other site 471853004166 ABC-ATPase subunit interface; other site 471853004167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004168 dimer interface [polypeptide binding]; other site 471853004169 conserved gate region; other site 471853004170 putative PBP binding loops; other site 471853004171 ABC-ATPase subunit interface; other site 471853004172 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 471853004173 putative metal binding site [ion binding]; other site 471853004174 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar3; cd08577 471853004175 putative active site [active] 471853004176 catalytic site [active] 471853004177 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 471853004178 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853004179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004180 dimer interface [polypeptide binding]; other site 471853004181 conserved gate region; other site 471853004182 putative PBP binding loops; other site 471853004183 ABC-ATPase subunit interface; other site 471853004184 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 471853004185 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004186 dimer interface [polypeptide binding]; other site 471853004187 putative PBP binding loops; other site 471853004188 ABC-ATPase subunit interface; other site 471853004189 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853004190 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853004191 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853004192 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853004193 DNA binding site [nucleotide binding] 471853004194 domain linker motif; other site 471853004195 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853004196 dimerization interface [polypeptide binding]; other site 471853004197 ligand binding site [chemical binding]; other site 471853004198 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471853004199 non-specific DNA binding site [nucleotide binding]; other site 471853004200 salt bridge; other site 471853004201 sequence-specific DNA binding site [nucleotide binding]; other site 471853004202 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853004203 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471853004204 active site 471853004205 metal binding site [ion binding]; metal-binding site 471853004206 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 471853004207 nudix motif; other site 471853004208 Transcriptional regulators [Transcription]; Region: GntR; COG1802 471853004209 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853004210 DNA-binding site [nucleotide binding]; DNA binding site 471853004211 FCD domain; Region: FCD; cl11656 471853004212 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 471853004213 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853004214 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471853004215 active site 471853004216 catalytic tetrad [active] 471853004217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004218 dimer interface [polypeptide binding]; other site 471853004219 conserved gate region; other site 471853004220 putative PBP binding loops; other site 471853004221 ABC-ATPase subunit interface; other site 471853004222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004223 dimer interface [polypeptide binding]; other site 471853004224 conserved gate region; other site 471853004225 putative PBP binding loops; other site 471853004226 ABC-ATPase subunit interface; other site 471853004227 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853004228 acetoin reductase; Validated; Region: PRK08643 471853004229 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853004230 NAD(P) binding site [chemical binding]; other site 471853004231 active site 471853004232 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK09260 471853004233 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853004234 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 471853004235 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471853004236 dihydroxyacetone kinase; Provisional; Region: PRK14479 471853004237 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 471853004238 DAK2 domain; Region: Dak2; cl03685 471853004239 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 471853004240 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 471853004241 substrate binding site [chemical binding]; other site 471853004242 dimer interface [polypeptide binding]; other site 471853004243 catalytic triad [active] 471853004244 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 471853004245 active site 471853004246 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 471853004247 YCII-related domain; Region: YCII; cl00999 471853004248 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 471853004249 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 471853004250 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471853004251 Walker A/P-loop; other site 471853004252 ATP binding site [chemical binding]; other site 471853004253 Q-loop/lid; other site 471853004254 ABC transporter signature motif; other site 471853004255 Walker B; other site 471853004256 D-loop; other site 471853004257 H-loop/switch region; other site 471853004258 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471853004259 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 471853004260 Walker A/P-loop; other site 471853004261 ATP binding site [chemical binding]; other site 471853004262 Q-loop/lid; other site 471853004263 ABC transporter signature motif; other site 471853004264 Walker B; other site 471853004265 D-loop; other site 471853004266 H-loop/switch region; other site 471853004267 Methyltransferase domain; Region: Methyltransf_31; pfam13847 471853004268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853004269 S-adenosylmethionine binding site [chemical binding]; other site 471853004270 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471853004271 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471853004272 DNA binding residues [nucleotide binding] 471853004273 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471853004274 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471853004275 DNA binding residues [nucleotide binding] 471853004276 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 471853004277 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 471853004278 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 471853004279 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 471853004280 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 471853004281 HIGH motif; other site 471853004282 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 471853004283 active site 471853004284 KMSKS motif; other site 471853004285 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 471853004286 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853004287 motif II; other site 471853004288 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853004289 Coenzyme A binding pocket [chemical binding]; other site 471853004290 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 471853004291 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853004292 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 471853004293 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 471853004294 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 471853004295 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471853004296 Helix-turn-helix domains; Region: HTH; cl00088 471853004297 Bacterial transcriptional regulator; Region: IclR; pfam01614 471853004298 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 471853004299 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 471853004300 substrate binding site [chemical binding]; other site 471853004301 ligand binding site [chemical binding]; other site 471853004302 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 471853004303 substrate binding site [chemical binding]; other site 471853004304 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 471853004305 alpha-amylase; Reviewed; Region: malS; PRK09505 471853004306 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853004307 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853004308 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 471853004309 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853004310 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853004311 DNA binding site [nucleotide binding] 471853004312 domain linker motif; other site 471853004313 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853004314 dimerization interface [polypeptide binding]; other site 471853004315 ligand binding site [chemical binding]; other site 471853004316 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853004317 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853004318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004319 dimer interface [polypeptide binding]; other site 471853004320 conserved gate region; other site 471853004321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853004322 ABC-ATPase subunit interface; other site 471853004323 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853004324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853004325 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 471853004326 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471853004327 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471853004328 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 471853004329 Walker A/P-loop; other site 471853004330 ATP binding site [chemical binding]; other site 471853004331 Q-loop/lid; other site 471853004332 ABC transporter signature motif; other site 471853004333 Walker B; other site 471853004334 D-loop; other site 471853004335 H-loop/switch region; other site 471853004336 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471853004337 Histidine kinase; Region: HisKA_3; pfam07730 471853004338 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853004339 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853004340 active site 471853004341 phosphorylation site [posttranslational modification] 471853004342 intermolecular recognition site; other site 471853004343 dimerization interface [polypeptide binding]; other site 471853004344 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853004345 DNA binding residues [nucleotide binding] 471853004346 dimerization interface [polypeptide binding]; other site 471853004347 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 471853004348 putative acyl-acceptor binding pocket; other site 471853004349 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 471853004350 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853004351 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 471853004352 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 471853004353 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 471853004354 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 471853004355 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 471853004356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853004357 putative substrate translocation pore; other site 471853004358 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 471853004359 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471853004360 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471853004361 catalytic residue [active] 471853004362 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 471853004363 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 471853004364 ATP-grasp domain; Region: ATP-grasp_4; cl03087 471853004365 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 471853004366 thiamine monophosphate kinase; Provisional; Region: PRK05731 471853004367 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 471853004368 ATP binding site [chemical binding]; other site 471853004369 dimerization interface [polypeptide binding]; other site 471853004370 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 471853004371 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853004372 Coenzyme A binding pocket [chemical binding]; other site 471853004373 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 471853004374 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 471853004375 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 471853004376 ssDNA binding site; other site 471853004377 generic binding surface II; other site 471853004378 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471853004379 ATP binding site [chemical binding]; other site 471853004380 putative Mg++ binding site [ion binding]; other site 471853004381 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471853004382 nucleotide binding region [chemical binding]; other site 471853004383 ATP-binding site [chemical binding]; other site 471853004384 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 471853004385 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853004386 Walker A/P-loop; other site 471853004387 ATP binding site [chemical binding]; other site 471853004388 Q-loop/lid; other site 471853004389 ABC transporter signature motif; other site 471853004390 Walker B; other site 471853004391 D-loop; other site 471853004392 H-loop/switch region; other site 471853004393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853004394 H+ Antiporter protein; Region: 2A0121; TIGR00900 471853004395 putative substrate translocation pore; other site 471853004396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853004397 S-adenosylmethionine binding site [chemical binding]; other site 471853004398 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 471853004399 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 471853004400 active site 471853004401 (T/H)XGH motif; other site 471853004402 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 471853004403 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 471853004404 ribonuclease III; Reviewed; Region: rnc; PRK00102 471853004405 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 471853004406 dimerization interface [polypeptide binding]; other site 471853004407 active site 471853004408 metal binding site [ion binding]; metal-binding site 471853004409 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 471853004410 dsRNA binding site [nucleotide binding]; other site 471853004411 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 471853004412 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 471853004413 DNA binding site [nucleotide binding] 471853004414 catalytic residue [active] 471853004415 H2TH interface [polypeptide binding]; other site 471853004416 putative catalytic residues [active] 471853004417 turnover-facilitating residue; other site 471853004418 intercalation triad [nucleotide binding]; other site 471853004419 8OG recognition residue [nucleotide binding]; other site 471853004420 putative reading head residues; other site 471853004421 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 471853004422 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 471853004423 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853004424 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853004425 active site 471853004426 phosphorylation site [posttranslational modification] 471853004427 intermolecular recognition site; other site 471853004428 dimerization interface [polypeptide binding]; other site 471853004429 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853004430 DNA binding residues [nucleotide binding] 471853004431 dimerization interface [polypeptide binding]; other site 471853004432 BLMT, a bleomycin resistance protein encoded on the transposon Tn5, and similar proteins; Region: BLMT_like; cd08350 471853004433 dimer interface [polypeptide binding]; other site 471853004434 ligand binding site [chemical binding]; other site 471853004435 GAF domain; Region: GAF; cl15785 471853004436 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471853004437 Histidine kinase; Region: HisKA_3; pfam07730 471853004438 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 471853004439 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 471853004440 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 471853004441 Walker A/P-loop; other site 471853004442 ATP binding site [chemical binding]; other site 471853004443 Q-loop/lid; other site 471853004444 ABC transporter signature motif; other site 471853004445 Walker B; other site 471853004446 D-loop; other site 471853004447 H-loop/switch region; other site 471853004448 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 471853004449 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853004450 Walker A/P-loop; other site 471853004451 ATP binding site [chemical binding]; other site 471853004452 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 471853004453 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 471853004454 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 471853004455 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 471853004456 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 471853004457 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 471853004458 homodimer interface [polypeptide binding]; other site 471853004459 oligonucleotide binding site [chemical binding]; other site 471853004460 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 471853004461 active site pocket [active] 471853004462 oxyanion hole [active] 471853004463 catalytic triad [active] 471853004464 active site nucleophile [active] 471853004465 Dodecin; Region: Dodecin; cl01328 471853004466 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 471853004467 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 471853004468 GTPase CgtA; Reviewed; Region: obgE; PRK12296 471853004469 GTP1/OBG; Region: GTP1_OBG; pfam01018 471853004470 Obg GTPase; Region: Obg; cd01898 471853004471 G1 box; other site 471853004472 GTP/Mg2+ binding site [chemical binding]; other site 471853004473 Switch I region; other site 471853004474 G2 box; other site 471853004475 G3 box; other site 471853004476 Switch II region; other site 471853004477 G4 box; other site 471853004478 G5 box; other site 471853004479 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 471853004480 gamma-glutamyl kinase; Provisional; Region: PRK05429 471853004481 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 471853004482 nucleotide binding site [chemical binding]; other site 471853004483 homotetrameric interface [polypeptide binding]; other site 471853004484 putative phosphate binding site [ion binding]; other site 471853004485 putative allosteric binding site; other site 471853004486 PUA domain; Region: PUA; cl00607 471853004487 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 471853004488 substrate binding site [chemical binding]; other site 471853004489 ATP binding site [chemical binding]; other site 471853004490 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 471853004491 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 471853004492 active site 471853004493 intersubunit interface [polypeptide binding]; other site 471853004494 catalytic residue [active] 471853004495 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471853004496 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471853004497 DNA binding residues [nucleotide binding] 471853004498 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 471853004499 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 471853004500 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 471853004501 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 471853004502 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 471853004503 active site 471853004504 (T/H)XGH motif; other site 471853004505 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 471853004506 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 471853004507 active site 471853004508 catalytic site [active] 471853004509 Oligomerisation domain; Region: Oligomerisation; cl00519 471853004510 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471853004511 catalytic core [active] 471853004512 phosphoethanolamine N-methyltransferase; Region: PLN02336 471853004513 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853004514 ZIP Zinc transporter; Region: Zip; pfam02535 471853004515 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471853004516 DNA binding site [nucleotide binding] 471853004517 Int/Topo IB signature motif; other site 471853004518 active site 471853004519 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853004520 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 471853004521 dimer interface [polypeptide binding]; other site 471853004522 Lsr2; Region: Lsr2; pfam11774 471853004523 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 471853004524 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 471853004525 active site 471853004526 metal binding site [ion binding]; metal-binding site 471853004527 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 471853004528 Helix-turn-helix domains; Region: HTH; cl00088 471853004529 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853004530 dimerization interface [polypeptide binding]; other site 471853004531 LysE type translocator; Region: LysE; cl00565 471853004532 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853004533 S-adenosylmethionine binding site [chemical binding]; other site 471853004534 Helix-turn-helix domains; Region: HTH; cl00088 471853004535 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471853004536 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853004537 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853004538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853004539 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853004540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004541 dimer interface [polypeptide binding]; other site 471853004542 conserved gate region; other site 471853004543 putative PBP binding loops; other site 471853004544 ABC-ATPase subunit interface; other site 471853004545 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853004546 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853004547 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 471853004548 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853004549 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853004550 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 471853004551 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853004552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853004553 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 471853004554 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 471853004555 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 471853004556 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 471853004557 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase; Provisional; Region: PTZ00322 471853004558 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 471853004559 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 471853004560 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 471853004561 Moco binding site; other site 471853004562 metal coordination site [ion binding]; other site 471853004563 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 471853004564 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471853004565 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853004566 Walker A/P-loop; other site 471853004567 ATP binding site [chemical binding]; other site 471853004568 Q-loop/lid; other site 471853004569 ABC transporter signature motif; other site 471853004570 Walker B; other site 471853004571 D-loop; other site 471853004572 H-loop/switch region; other site 471853004573 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471853004574 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 471853004575 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 471853004576 Walker A/P-loop; other site 471853004577 ATP binding site [chemical binding]; other site 471853004578 Q-loop/lid; other site 471853004579 ABC transporter signature motif; other site 471853004580 Walker B; other site 471853004581 D-loop; other site 471853004582 H-loop/switch region; other site 471853004583 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853004584 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 471853004585 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471853004586 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 471853004587 active site 471853004588 ATP binding site [chemical binding]; other site 471853004589 GAF domain; Region: GAF; cl15785 471853004590 ANTAR domain; Region: ANTAR; cl04297 471853004591 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 471853004592 nucleoside/Zn binding site; other site 471853004593 catalytic motif [active] 471853004594 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471853004595 FAD binding domain; Region: FAD_binding_4; pfam01565 471853004596 Helix-turn-helix domains; Region: HTH; cl00088 471853004597 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471853004598 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471853004599 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 471853004600 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 471853004601 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 471853004602 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 471853004603 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 471853004604 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 471853004605 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 471853004606 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 471853004607 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 471853004608 methylenetetrahydromethanopterin reductase; Provisional; Region: PRK02271 471853004609 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471853004610 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 471853004611 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471853004612 active site 471853004613 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853004614 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 471853004615 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004616 dimer interface [polypeptide binding]; other site 471853004617 conserved gate region; other site 471853004618 putative PBP binding loops; other site 471853004619 ABC-ATPase subunit interface; other site 471853004620 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853004621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004622 dimer interface [polypeptide binding]; other site 471853004623 conserved gate region; other site 471853004624 putative PBP binding loops; other site 471853004625 ABC-ATPase subunit interface; other site 471853004626 cytosine deaminase; Provisional; Region: PRK05985 471853004627 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 471853004628 active site 471853004629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853004630 putative substrate translocation pore; other site 471853004631 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 471853004632 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 471853004633 metal binding site [ion binding]; metal-binding site 471853004634 substrate binding pocket [chemical binding]; other site 471853004635 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 471853004636 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853004637 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 471853004638 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471853004639 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471853004640 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 471853004641 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 471853004642 XdhC Rossmann domain; Region: XdhC_C; pfam13478 471853004643 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 471853004644 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471853004645 FeS/SAM binding site; other site 471853004646 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 471853004647 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 471853004648 MoaE interaction surface [polypeptide binding]; other site 471853004649 MoeB interaction surface [polypeptide binding]; other site 471853004650 thiocarboxylated glycine; other site 471853004651 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 471853004652 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 471853004653 MoaE homodimer interface [polypeptide binding]; other site 471853004654 MoaD interaction [polypeptide binding]; other site 471853004655 active site residues [active] 471853004656 bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604 471853004657 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 471853004658 trimer interface [polypeptide binding]; other site 471853004659 dimer interface [polypeptide binding]; other site 471853004660 putative active site [active] 471853004661 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 471853004662 MPT binding site; other site 471853004663 trimer interface [polypeptide binding]; other site 471853004664 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 471853004665 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 471853004666 ATP binding site [chemical binding]; other site 471853004667 substrate interface [chemical binding]; other site 471853004668 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 471853004669 active site residue [active] 471853004670 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853004671 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853004672 DNA binding site [nucleotide binding] 471853004673 domain linker motif; other site 471853004674 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853004675 ligand binding site [chemical binding]; other site 471853004676 dimerization interface [polypeptide binding]; other site 471853004677 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 471853004678 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853004679 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853004680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004681 dimer interface [polypeptide binding]; other site 471853004682 conserved gate region; other site 471853004683 putative PBP binding loops; other site 471853004684 ABC-ATPase subunit interface; other site 471853004685 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853004686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004687 dimer interface [polypeptide binding]; other site 471853004688 conserved gate region; other site 471853004689 putative PBP binding loops; other site 471853004690 ABC-ATPase subunit interface; other site 471853004691 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 471853004692 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853004693 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 471853004694 YCII-related domain; Region: YCII; cl00999 471853004695 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 471853004696 Predicted sugar phosphate isomerase involved in capsule formation [Cell envelope biogenesis, outer membrane]; Region: GutQ; COG0794 471853004697 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 471853004698 putative active site [active] 471853004699 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471853004700 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 471853004701 substrate binding site [chemical binding]; other site 471853004702 dimer interface [polypeptide binding]; other site 471853004703 ATP binding site [chemical binding]; other site 471853004704 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 471853004705 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 471853004706 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853004707 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 471853004708 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853004709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004710 dimer interface [polypeptide binding]; other site 471853004711 conserved gate region; other site 471853004712 putative PBP binding loops; other site 471853004713 ABC-ATPase subunit interface; other site 471853004714 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853004715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004716 dimer interface [polypeptide binding]; other site 471853004717 conserved gate region; other site 471853004718 putative PBP binding loops; other site 471853004719 ABC-ATPase subunit interface; other site 471853004720 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853004721 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 471853004722 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 471853004723 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 471853004724 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 471853004725 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471853004726 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471853004727 active site 471853004728 metal binding site [ion binding]; metal-binding site 471853004729 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824 471853004730 putative hydrophobic ligand binding site [chemical binding]; other site 471853004731 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 471853004732 Uncharacterized conserved protein [Function unknown]; Region: COG3595 471853004733 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 471853004734 Vitamin K epoxide reductase family; Region: VKOR; cl01729 471853004735 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 471853004736 Domain of unknown function DUF21; Region: DUF21; pfam01595 471853004737 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471853004738 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 471853004739 Domain of unknown function DUF21; Region: DUF21; pfam01595 471853004740 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471853004741 Transporter associated domain; Region: CorC_HlyC; cl08393 471853004742 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 471853004743 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471853004744 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471853004745 Helix-turn-helix domains; Region: HTH; cl00088 471853004746 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 471853004747 Helix-turn-helix domains; Region: HTH; cl00088 471853004748 Domain of unknown function (DUF385); Region: DUF385; cl04387 471853004749 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 471853004750 Ferritin-like domain; Region: Ferritin; pfam00210 471853004751 dimerization interface [polypeptide binding]; other site 471853004752 DPS ferroxidase diiron center [ion binding]; other site 471853004753 ion pore; other site 471853004754 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 471853004755 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471853004756 active site 471853004757 HIGH motif; other site 471853004758 nucleotide binding site [chemical binding]; other site 471853004759 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471853004760 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 471853004761 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471853004762 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471853004763 active site 471853004764 KMSKS motif; other site 471853004765 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 471853004766 tRNA binding surface [nucleotide binding]; other site 471853004767 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 471853004768 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853004769 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853004770 active site 471853004771 phosphorylation site [posttranslational modification] 471853004772 intermolecular recognition site; other site 471853004773 dimerization interface [polypeptide binding]; other site 471853004774 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853004775 DNA binding residues [nucleotide binding] 471853004776 dimerization interface [polypeptide binding]; other site 471853004777 Histidine kinase; Region: HisKA_3; pfam07730 471853004778 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471853004779 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853004780 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 471853004781 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853004782 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 471853004783 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853004784 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 471853004785 Competence protein; Region: Competence; cl00471 471853004786 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471853004787 hypothetical protein; Reviewed; Region: PRK07914 471853004788 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 471853004789 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 471853004790 PemK-like protein; Region: PemK; cl00995 471853004791 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 471853004792 GTP-binding protein LepA; Provisional; Region: PRK05433 471853004793 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 471853004794 G1 box; other site 471853004795 putative GEF interaction site [polypeptide binding]; other site 471853004796 GTP/Mg2+ binding site [chemical binding]; other site 471853004797 Switch I region; other site 471853004798 G2 box; other site 471853004799 G3 box; other site 471853004800 Switch II region; other site 471853004801 G4 box; other site 471853004802 G5 box; other site 471853004803 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 471853004804 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 471853004805 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 471853004806 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 471853004807 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471853004808 FeS/SAM binding site; other site 471853004809 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 471853004810 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 471853004811 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 471853004812 Helix-turn-helix domains; Region: HTH; cl00088 471853004813 HrcA protein C terminal domain; Region: HrcA; pfam01628 471853004814 chaperone protein DnaJ; Provisional; Region: PRK14278 471853004815 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 471853004816 HSP70 interaction site [polypeptide binding]; other site 471853004817 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 471853004818 Zn binding sites [ion binding]; other site 471853004819 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 471853004820 dimer interface [polypeptide binding]; other site 471853004821 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 471853004822 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853004823 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 471853004824 GTPase Era; Reviewed; Region: era; PRK00089 471853004825 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 471853004826 G1 box; other site 471853004827 GTP/Mg2+ binding site [chemical binding]; other site 471853004828 Switch I region; other site 471853004829 G2 box; other site 471853004830 Switch II region; other site 471853004831 G3 box; other site 471853004832 G4 box; other site 471853004833 G5 box; other site 471853004834 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 471853004835 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 471853004836 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 471853004837 active site 471853004838 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471853004839 phosphopeptide binding site; other site 471853004840 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471853004841 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471853004842 active site 471853004843 ATP binding site [chemical binding]; other site 471853004844 substrate binding site [chemical binding]; other site 471853004845 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471853004846 substrate binding site [chemical binding]; other site 471853004847 activation loop (A-loop); other site 471853004848 activation loop (A-loop); other site 471853004849 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 471853004850 Interdomain contacts; other site 471853004851 Cytokine receptor motif; other site 471853004852 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 471853004853 Interdomain contacts; other site 471853004854 Cytokine receptor motif; other site 471853004855 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 471853004856 MoxR-like ATPases [General function prediction only]; Region: COG0714 471853004857 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471853004858 Walker A motif; other site 471853004859 ATP binding site [chemical binding]; other site 471853004860 Walker B motif; other site 471853004861 arginine finger; other site 471853004862 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 471853004863 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471853004864 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 471853004865 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 471853004866 2-isopropylmalate synthase; Validated; Region: PRK03739 471853004867 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 471853004868 active site 471853004869 catalytic residues [active] 471853004870 metal binding site [ion binding]; metal-binding site 471853004871 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 471853004872 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 471853004873 Lumazine binding domain; Region: Lum_binding; pfam00677 471853004874 Lumazine binding domain; Region: Lum_binding; pfam00677 471853004875 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 471853004876 Recombination protein O N terminal; Region: RecO_N; cl15812 471853004877 Recombination protein O C terminal; Region: RecO_C; pfam02565 471853004878 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 471853004879 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 471853004880 catalytic residue [active] 471853004881 putative FPP diphosphate binding site; other site 471853004882 putative FPP binding hydrophobic cleft; other site 471853004883 dimer interface [polypeptide binding]; other site 471853004884 putative IPP diphosphate binding site; other site 471853004885 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 471853004886 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 471853004887 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 471853004888 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 471853004889 metal binding site 2 [ion binding]; metal-binding site 471853004890 putative DNA binding helix; other site 471853004891 metal binding site 1 [ion binding]; metal-binding site 471853004892 dimer interface [polypeptide binding]; other site 471853004893 structural Zn2+ binding site [ion binding]; other site 471853004894 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 471853004895 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 471853004896 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 471853004897 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 471853004898 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 471853004899 intersubunit interface [polypeptide binding]; other site 471853004900 glycyl-tRNA synthetase; Provisional; Region: PRK04173 471853004901 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 471853004902 motif 1; other site 471853004903 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 471853004904 active site 471853004905 motif 2; other site 471853004906 motif 3; other site 471853004907 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 471853004908 anticodon binding site; other site 471853004909 YibE/F-like protein; Region: YibE_F; cl02259 471853004910 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 471853004911 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 471853004912 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 471853004913 FMN binding site [chemical binding]; other site 471853004914 active site 471853004915 catalytic residues [active] 471853004916 substrate binding site [chemical binding]; other site 471853004917 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853004918 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853004919 DNA binding site [nucleotide binding] 471853004920 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 471853004921 putative dimerization interface [polypeptide binding]; other site 471853004922 putative ligand binding site [chemical binding]; other site 471853004923 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 471853004924 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004925 dimer interface [polypeptide binding]; other site 471853004926 conserved gate region; other site 471853004927 putative PBP binding loops; other site 471853004928 ABC-ATPase subunit interface; other site 471853004929 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 471853004930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004931 dimer interface [polypeptide binding]; other site 471853004932 conserved gate region; other site 471853004933 putative PBP binding loops; other site 471853004934 ABC-ATPase subunit interface; other site 471853004935 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 471853004936 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 471853004937 active site 471853004938 catalytic site [active] 471853004939 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 471853004940 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 471853004941 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 471853004942 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 471853004943 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471853004944 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471853004945 DNA primase, catalytic core; Region: dnaG; TIGR01391 471853004946 CHC2 zinc finger; Region: zf-CHC2; cl15369 471853004947 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 471853004948 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 471853004949 active site 471853004950 metal binding site [ion binding]; metal-binding site 471853004951 interdomain interaction site; other site 471853004952 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 471853004953 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471853004954 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853004955 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 471853004956 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 471853004957 active site 471853004958 non-prolyl cis peptide bond; other site 471853004959 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 471853004960 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471853004961 active site 471853004962 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 471853004963 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471853004964 Walker A/P-loop; other site 471853004965 ATP binding site [chemical binding]; other site 471853004966 Q-loop/lid; other site 471853004967 ABC transporter signature motif; other site 471853004968 Walker B; other site 471853004969 D-loop; other site 471853004970 H-loop/switch region; other site 471853004971 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853004972 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471853004973 Walker A/P-loop; other site 471853004974 ATP binding site [chemical binding]; other site 471853004975 Q-loop/lid; other site 471853004976 ABC transporter signature motif; other site 471853004977 Walker B; other site 471853004978 D-loop; other site 471853004979 H-loop/switch region; other site 471853004980 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853004981 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 471853004982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004983 dimer interface [polypeptide binding]; other site 471853004984 conserved gate region; other site 471853004985 putative PBP binding loops; other site 471853004986 ABC-ATPase subunit interface; other site 471853004987 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471853004988 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004989 dimer interface [polypeptide binding]; other site 471853004990 conserved gate region; other site 471853004991 putative PBP binding loops; other site 471853004992 ABC-ATPase subunit interface; other site 471853004993 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 471853004994 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471853004995 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 471853004996 active site 471853004997 catalytic residues [active] 471853004998 metal binding site [ion binding]; metal-binding site 471853004999 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 471853005000 Phosphotransferase enzyme family; Region: APH; pfam01636 471853005001 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471853005002 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471853005003 active site 471853005004 metal binding site [ion binding]; metal-binding site 471853005005 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 471853005006 Predicted acetyltransferase [General function prediction only]; Region: COG3981 471853005007 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853005008 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 471853005009 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 471853005010 dimer interface [polypeptide binding]; other site 471853005011 active site 471853005012 Phosphopantetheine attachment site; Region: PP-binding; cl09936 471853005013 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 471853005014 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 471853005015 dimer interface [polypeptide binding]; other site 471853005016 active site 471853005017 CoA binding pocket [chemical binding]; other site 471853005018 Acyl transferase domain; Region: Acyl_transf_1; cl08282 471853005019 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 471853005020 Helix-turn-helix domains; Region: HTH; cl00088 471853005021 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 471853005022 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 471853005023 dimer interface [polypeptide binding]; other site 471853005024 TPP-binding site [chemical binding]; other site 471853005025 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 471853005026 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471853005027 CAAX protease self-immunity; Region: Abi; cl00558 471853005028 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 471853005029 Cupin domain; Region: Cupin_2; cl09118 471853005030 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471853005031 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853005032 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 471853005033 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853005034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853005035 active site 471853005036 phosphorylation site [posttranslational modification] 471853005037 intermolecular recognition site; other site 471853005038 dimerization interface [polypeptide binding]; other site 471853005039 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853005040 DNA binding residues [nucleotide binding] 471853005041 dimerization interface [polypeptide binding]; other site 471853005042 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 471853005043 Histidine kinase; Region: HisKA_3; pfam07730 471853005044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471853005045 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471853005046 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 471853005047 putative NAD(P) binding site [chemical binding]; other site 471853005048 Domain of unknown function (DUF385); Region: DUF385; cl04387 471853005049 Putative glycolipid-binding; Region: Glycolipid_bind; cl01425 471853005050 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471853005051 active site 471853005052 metal binding site [ion binding]; metal-binding site 471853005053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853005054 S-adenosylmethionine binding site [chemical binding]; other site 471853005055 Acyltransferase family; Region: Acyl_transf_3; pfam01757 471853005056 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 471853005057 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 471853005058 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 471853005059 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 471853005060 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471853005061 active site 471853005062 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 471853005063 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 471853005064 Protein of unknown function (DUF328); Region: DUF328; cl01143 471853005065 Arginase family; Region: Arginase; cl00306 471853005066 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 471853005067 Helix-turn-helix domains; Region: HTH; cl00088 471853005068 Bacterial transcriptional regulator; Region: IclR; pfam01614 471853005069 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 471853005070 active sites [active] 471853005071 tetramer interface [polypeptide binding]; other site 471853005072 urocanate hydratase; Provisional; Region: PRK05414 471853005073 imidazolonepropionase; Provisional; Region: PRK14085 471853005074 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471853005075 active site 471853005076 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 471853005077 Helix-turn-helix domains; Region: HTH; cl00088 471853005078 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 471853005079 A new structural DNA glycosylase; Region: AlkD_like; cd06561 471853005080 active site 471853005081 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471853005082 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471853005083 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471853005084 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 471853005085 oligomerization interface [polypeptide binding]; other site 471853005086 active site 471853005087 metal binding site [ion binding]; metal-binding site 471853005088 NAD synthetase; Provisional; Region: PRK13981 471853005089 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 471853005090 multimer interface [polypeptide binding]; other site 471853005091 active site 471853005092 catalytic triad [active] 471853005093 protein interface 1 [polypeptide binding]; other site 471853005094 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 471853005095 homodimer interface [polypeptide binding]; other site 471853005096 NAD binding pocket [chemical binding]; other site 471853005097 ATP binding pocket [chemical binding]; other site 471853005098 Mg binding site [ion binding]; other site 471853005099 active-site loop [active] 471853005100 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 471853005101 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 471853005102 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 471853005103 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 471853005104 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 471853005105 metal binding triad; other site 471853005106 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 471853005107 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 471853005108 metal binding triad; other site 471853005109 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 471853005110 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853005111 Predicted ATPase [General function prediction only]; Region: COG3899 471853005112 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853005113 DNA binding residues [nucleotide binding] 471853005114 dimerization interface [polypeptide binding]; other site 471853005115 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 471853005116 glutamine synthetase, type I; Region: GlnA; TIGR00653 471853005117 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 471853005118 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 471853005119 RDD family; Region: RDD; cl00746 471853005120 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 471853005121 lipoyl synthase; Provisional; Region: PRK05481 471853005122 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471853005123 FeS/SAM binding site; other site 471853005124 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 471853005125 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471853005126 active site 471853005127 ATP binding site [chemical binding]; other site 471853005128 substrate binding site [chemical binding]; other site 471853005129 activation loop (A-loop); other site 471853005130 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853005131 active site 471853005132 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471853005133 E3 interaction surface; other site 471853005134 lipoyl attachment site [posttranslational modification]; other site 471853005135 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471853005136 E3 interaction surface; other site 471853005137 lipoyl attachment site [posttranslational modification]; other site 471853005138 e3 binding domain; Region: E3_binding; pfam02817 471853005139 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 471853005140 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 471853005141 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 471853005142 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471853005143 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471853005144 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 471853005145 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 471853005146 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 471853005147 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 471853005148 Helix-turn-helix domains; Region: HTH; cl00088 471853005149 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 471853005150 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 471853005151 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853005152 Protein of unknown function, DUF624; Region: DUF624; cl02369 471853005153 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853005154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853005155 dimer interface [polypeptide binding]; other site 471853005156 conserved gate region; other site 471853005157 putative PBP binding loops; other site 471853005158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853005159 ABC-ATPase subunit interface; other site 471853005160 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 471853005161 interface (dimer of trimers) [polypeptide binding]; other site 471853005162 Substrate-binding/catalytic site; other site 471853005163 Zn-binding sites [ion binding]; other site 471853005164 hypothetical protein; Provisional; Region: PRK05415 471853005165 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 471853005166 quinone interaction residues [chemical binding]; other site 471853005167 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 471853005168 active site 471853005169 catalytic residues [active] 471853005170 FMN binding site [chemical binding]; other site 471853005171 substrate binding site [chemical binding]; other site 471853005172 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 471853005173 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853005174 active site 471853005175 catalytic tetrad [active] 471853005176 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 471853005177 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 471853005178 active site 471853005179 metal binding site [ion binding]; metal-binding site 471853005180 dimer interface [polypeptide binding]; other site 471853005181 Glycerate kinase family; Region: Gly_kinase; cl00841 471853005182 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 471853005183 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 471853005184 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 471853005185 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 471853005186 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 471853005187 D-pathway; other site 471853005188 Putative ubiquinol binding site [chemical binding]; other site 471853005189 Low-spin heme (heme b) binding site [chemical binding]; other site 471853005190 Putative water exit pathway; other site 471853005191 Binuclear center (heme o3/CuB) [ion binding]; other site 471853005192 K-pathway; other site 471853005193 Putative proton exit pathway; other site 471853005194 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 471853005195 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 471853005196 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 471853005197 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 471853005198 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 471853005199 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 471853005200 heme bH binding site [chemical binding]; other site 471853005201 intrachain domain interface; other site 471853005202 heme bL binding site [chemical binding]; other site 471853005203 interchain domain interface [polypeptide binding]; other site 471853005204 Qo binding site; other site 471853005205 Rieske iron-sulfur protein SoxL2; Region: soxL2; TIGR03171 471853005206 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 471853005207 iron-sulfur cluster [ion binding]; other site 471853005208 [2Fe-2S] cluster binding site [ion binding]; other site 471853005209 Cytochrome c; Region: Cytochrom_C; cl11414 471853005210 Cytochrome c; Region: Cytochrom_C; cl11414 471853005211 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 471853005212 Subunit I/III interface [polypeptide binding]; other site 471853005213 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471853005214 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 471853005215 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 471853005216 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 471853005217 Helix-turn-helix domains; Region: HTH; cl00088 471853005218 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471853005219 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 471853005220 NAD(P) binding site [chemical binding]; other site 471853005221 catalytic residues [active] 471853005222 Helix-turn-helix domains; Region: HTH; cl00088 471853005223 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 471853005224 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471853005225 catalytic residue [active] 471853005226 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 471853005227 FAD binding domain; Region: FAD_binding_4; pfam01565 471853005228 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 471853005229 hypothetical protein; Validated; Region: PRK07883 471853005230 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 471853005231 active site 471853005232 substrate binding site [chemical binding]; other site 471853005233 catalytic site [active] 471853005234 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 471853005235 GIY-YIG motif/motif A; other site 471853005236 active site 471853005237 catalytic site [active] 471853005238 putative DNA binding site [nucleotide binding]; other site 471853005239 metal binding site [ion binding]; metal-binding site 471853005240 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 471853005241 AMP-binding enzyme; Region: AMP-binding; cl15778 471853005242 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 471853005243 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471853005244 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 471853005245 putative acyl-acceptor binding pocket; other site 471853005246 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 471853005247 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 471853005248 active site 471853005249 ADP/pyrophosphate binding site [chemical binding]; other site 471853005250 allosteric effector site; other site 471853005251 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 471853005252 fructose-1,6-bisphosphate binding site; other site 471853005253 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 471853005254 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 471853005255 Moco binding site; other site 471853005256 metal coordination site [ion binding]; other site 471853005257 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471853005258 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471853005259 active site 471853005260 ATP binding site [chemical binding]; other site 471853005261 substrate binding site [chemical binding]; other site 471853005262 activation loop (A-loop); other site 471853005263 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471853005264 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471853005265 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 471853005266 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471853005267 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 471853005268 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 471853005269 substrate binding pocket [chemical binding]; other site 471853005270 substrate-Mg2+ binding site; other site 471853005271 aspartate-rich region 1; other site 471853005272 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 471853005273 aspartate-rich region 2; other site 471853005274 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 471853005275 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471853005276 Ligand Binding Site [chemical binding]; other site 471853005277 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 471853005278 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 471853005279 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 471853005280 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 471853005281 lipoyl attachment site [posttranslational modification]; other site 471853005282 glycine dehydrogenase; Provisional; Region: PRK05367 471853005283 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 471853005284 tetramer interface [polypeptide binding]; other site 471853005285 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853005286 catalytic residue [active] 471853005287 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 471853005288 tetramer interface [polypeptide binding]; other site 471853005289 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853005290 catalytic residue [active] 471853005291 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 471853005292 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 471853005293 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853005294 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 471853005295 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471853005296 DNA binding residues [nucleotide binding] 471853005297 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853005298 dimerization interface [polypeptide binding]; other site 471853005299 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853005300 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853005301 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 471853005302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471853005303 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 471853005304 ATP binding site [chemical binding]; other site 471853005305 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 471853005306 active site 471853005307 metal binding site [ion binding]; metal-binding site 471853005308 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 471853005309 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853005310 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853005311 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 471853005312 active site 471853005313 metal binding site [ion binding]; metal-binding site 471853005314 dimer interface [polypeptide binding]; other site 471853005315 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 471853005316 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 471853005317 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 471853005318 CAP-like domain; other site 471853005319 active site 471853005320 primary dimer interface [polypeptide binding]; other site 471853005321 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471853005322 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471853005323 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 471853005324 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853005325 CoA-ligase; Region: Ligase_CoA; cl02894 471853005326 ATP-grasp domain; Region: ATP-grasp_4; cl03087 471853005327 Sulfatase; Region: Sulfatase; cl10460 471853005328 thymidine kinase; Provisional; Region: PRK04296 471853005329 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 471853005330 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 471853005331 active site 471853005332 dimerization interface [polypeptide binding]; other site 471853005333 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 471853005334 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 471853005335 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 471853005336 trimer interface [polypeptide binding]; other site 471853005337 active site 471853005338 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 471853005339 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 471853005340 ssDNA binding site; other site 471853005341 generic binding surface II; other site 471853005342 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 471853005343 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853005344 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 471853005345 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 471853005346 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853005347 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 471853005348 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 471853005349 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 471853005350 TRAM domain; Region: TRAM; cl01282 471853005351 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 471853005352 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 471853005353 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471853005354 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853005355 motif II; other site 471853005356 aconitate hydratase; Validated; Region: PRK09277 471853005357 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 471853005358 substrate binding site [chemical binding]; other site 471853005359 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 471853005360 ligand binding site [chemical binding]; other site 471853005361 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 471853005362 substrate binding site [chemical binding]; other site 471853005363 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 471853005364 reactive center loop; other site 471853005365 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 471853005366 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471853005367 active site 471853005368 substrate binding site [chemical binding]; other site 471853005369 ATP binding site [chemical binding]; other site 471853005370 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 471853005371 putative active site [active] 471853005372 putative CoA binding site [chemical binding]; other site 471853005373 nudix motif; other site 471853005374 metal binding site [ion binding]; metal-binding site 471853005375 UPF0126 domain; Region: UPF0126; pfam03458 471853005376 UPF0126 domain; Region: UPF0126; pfam03458 471853005377 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 471853005378 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 471853005379 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 471853005380 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 471853005381 active site 471853005382 YCII-related domain; Region: YCII; cl00999 471853005383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853005384 dimer interface [polypeptide binding]; other site 471853005385 conserved gate region; other site 471853005386 ABC-ATPase subunit interface; other site 471853005387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853005388 dimer interface [polypeptide binding]; other site 471853005389 conserved gate region; other site 471853005390 putative PBP binding loops; other site 471853005391 ABC-ATPase subunit interface; other site 471853005392 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853005393 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853005394 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853005395 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853005396 DNA binding site [nucleotide binding] 471853005397 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 471853005398 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 471853005399 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 471853005400 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 471853005401 TPP-binding site; other site 471853005402 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 471853005403 PYR/PP interface [polypeptide binding]; other site 471853005404 dimer interface [polypeptide binding]; other site 471853005405 TPP binding site [chemical binding]; other site 471853005406 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471853005407 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471853005408 substrate binding site [chemical binding]; other site 471853005409 oxyanion hole (OAH) forming residues; other site 471853005410 trimer interface [polypeptide binding]; other site 471853005411 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853005412 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 471853005413 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471853005414 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 471853005415 dimer interface [polypeptide binding]; other site 471853005416 active site 471853005417 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 471853005418 putative active site [active] 471853005419 putative substrate binding site [chemical binding]; other site 471853005420 catalytic site [active] 471853005421 HRDC domain; Region: HRDC; cl02578 471853005422 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 471853005423 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 471853005424 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 471853005425 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 471853005426 ATP-grasp domain; Region: ATP-grasp_4; cl03087 471853005427 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 471853005428 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853005429 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 471853005430 nucleotide binding site/active site [active] 471853005431 HIT family signature motif; other site 471853005432 catalytic residue [active] 471853005433 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 471853005434 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 471853005435 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 471853005436 catalytic site [active] 471853005437 active site 471853005438 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 471853005439 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 471853005440 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 471853005441 active site 471853005442 catalytic site [active] 471853005443 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 471853005444 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 471853005445 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 471853005446 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 471853005447 active site 471853005448 catalytic site [active] 471853005449 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 471853005450 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 471853005451 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 471853005452 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 471853005453 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853005454 catalytic residue [active] 471853005455 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 471853005456 inhibitor site; inhibition site 471853005457 active site 471853005458 dimer interface [polypeptide binding]; other site 471853005459 catalytic residue [active] 471853005460 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 471853005461 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 471853005462 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 471853005463 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 471853005464 active site 471853005465 dimer interface [polypeptide binding]; other site 471853005466 motif 1; other site 471853005467 motif 2; other site 471853005468 motif 3; other site 471853005469 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 471853005470 anticodon binding site; other site 471853005471 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 471853005472 nucleotide binding site/active site [active] 471853005473 HIT family signature motif; other site 471853005474 catalytic residue [active] 471853005475 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 471853005476 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853005477 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 471853005478 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 471853005479 putative acyl-acceptor binding pocket; other site 471853005480 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471853005481 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 471853005482 Protease prsW family; Region: PrsW-protease; cl15823 471853005483 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 471853005484 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 471853005485 active site 471853005486 multimer interface [polypeptide binding]; other site 471853005487 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 471853005488 nudix motif; other site 471853005489 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 471853005490 predicted active site [active] 471853005491 catalytic triad [active] 471853005492 Transcriptional regulator; Region: Transcrip_reg; cl00361 471853005493 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 471853005494 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 471853005495 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 471853005496 active site 471853005497 putative DNA-binding cleft [nucleotide binding]; other site 471853005498 dimer interface [polypeptide binding]; other site 471853005499 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 471853005500 RuvA N terminal domain; Region: RuvA_N; pfam01330 471853005501 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 471853005502 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471853005503 Walker A motif; other site 471853005504 ATP binding site [chemical binding]; other site 471853005505 Walker B motif; other site 471853005506 arginine finger; other site 471853005507 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 471853005508 Preprotein translocase subunit; Region: YajC; cl00806 471853005509 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 471853005510 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 471853005511 Protein export membrane protein; Region: SecD_SecF; cl14618 471853005512 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 471853005513 Protein export membrane protein; Region: SecD_SecF; cl14618 471853005514 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 471853005515 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 471853005516 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 471853005517 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 471853005518 synthetase active site [active] 471853005519 NTP binding site [chemical binding]; other site 471853005520 metal binding site [ion binding]; metal-binding site 471853005521 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 471853005522 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 471853005523 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 471853005524 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 471853005525 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 471853005526 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 471853005527 active site 471853005528 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 471853005529 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 471853005530 dimer interface [polypeptide binding]; other site 471853005531 motif 1; other site 471853005532 active site 471853005533 motif 2; other site 471853005534 motif 3; other site 471853005535 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 471853005536 anticodon binding site; other site 471853005537 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471853005538 Radical SAM superfamily; Region: Radical_SAM; pfam04055 471853005539 FeS/SAM binding site; other site 471853005540 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 471853005541 ATP binding site [chemical binding]; other site 471853005542 Mg++ binding site [ion binding]; other site 471853005543 motif III; other site 471853005544 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471853005545 nucleotide binding region [chemical binding]; other site 471853005546 ATP-binding site [chemical binding]; other site 471853005547 DbpA RNA binding domain; Region: DbpA; pfam03880 471853005548 aspartate aminotransferase; Provisional; Region: PRK05764 471853005549 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471853005550 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853005551 homodimer interface [polypeptide binding]; other site 471853005552 catalytic residue [active] 471853005553 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 471853005554 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 471853005555 dimer interface [polypeptide binding]; other site 471853005556 anticodon binding site; other site 471853005557 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 471853005558 homodimer interface [polypeptide binding]; other site 471853005559 motif 1; other site 471853005560 active site 471853005561 motif 2; other site 471853005562 GAD domain; Region: GAD; pfam02938 471853005563 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 471853005564 active site 471853005565 motif 3; other site 471853005566 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 471853005567 recombination factor protein RarA; Reviewed; Region: PRK13342 471853005568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471853005569 Walker A motif; other site 471853005570 ATP binding site [chemical binding]; other site 471853005571 Walker B motif; other site 471853005572 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 471853005573 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 471853005574 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 471853005575 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471853005576 RNA binding surface [nucleotide binding]; other site 471853005577 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 471853005578 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 471853005579 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 471853005580 motif 1; other site 471853005581 active site 471853005582 motif 2; other site 471853005583 motif 3; other site 471853005584 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 471853005585 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 471853005586 YceG-like family; Region: YceG; pfam02618 471853005587 proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675 471853005588 dimerization interface [polypeptide binding]; other site 471853005589 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 471853005590 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 471853005591 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 471853005592 shikimate binding site; other site 471853005593 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 471853005594 Tetramer interface [polypeptide binding]; other site 471853005595 active site 471853005596 FMN-binding site [chemical binding]; other site 471853005597 shikimate kinase; Reviewed; Region: aroK; PRK00131 471853005598 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 471853005599 ADP binding site [chemical binding]; other site 471853005600 magnesium binding site [ion binding]; other site 471853005601 putative shikimate binding site; other site 471853005602 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 471853005603 dimer interface [polypeptide binding]; other site 471853005604 active site 471853005605 metal binding site [ion binding]; metal-binding site 471853005606 Helix-turn-helix domains; Region: HTH; cl00088 471853005607 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 471853005608 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 471853005609 tetramer interface [polypeptide binding]; other site 471853005610 active site 471853005611 Mg2+/Mn2+ binding site [ion binding]; other site 471853005612 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 471853005613 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471853005614 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471853005615 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853005616 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 471853005617 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 471853005618 elongation factor P; Validated; Region: PRK00529 471853005619 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 471853005620 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 471853005621 RNA binding site [nucleotide binding]; other site 471853005622 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 471853005623 RNA binding site [nucleotide binding]; other site 471853005624 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 471853005625 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 471853005626 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 471853005627 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 471853005628 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853005629 dihydroorotase; Validated; Region: pyrC; PRK09357 471853005630 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471853005631 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 471853005632 active site 471853005633 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 471853005634 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 471853005635 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 471853005636 catalytic site [active] 471853005637 subunit interface [polypeptide binding]; other site 471853005638 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 471853005639 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471853005640 ATP-grasp domain; Region: ATP-grasp_4; cl03087 471853005641 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 471853005642 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471853005643 ATP-grasp domain; Region: ATP-grasp_4; cl03087 471853005644 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 471853005645 IMP binding site; other site 471853005646 dimer interface [polypeptide binding]; other site 471853005647 interdomain contacts; other site 471853005648 partial ornithine binding site; other site 471853005649 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 471853005650 active site 471853005651 dimer interface [polypeptide binding]; other site 471853005652 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 471853005653 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 471853005654 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 471853005655 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 471853005656 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 471853005657 Guanylate kinase; Region: Guanylate_kin; pfam00625 471853005658 catalytic site [active] 471853005659 G-X2-G-X-G-K; other site 471853005660 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 471853005661 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 471853005662 Flavoprotein; Region: Flavoprotein; cl08021 471853005663 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 471853005664 S-adenosylmethionine synthetase; Validated; Region: PRK05250 471853005665 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 471853005666 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 471853005667 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 471853005668 primosome assembly protein PriA; Provisional; Region: PRK14873 471853005669 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 471853005670 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853005671 motif II; other site 471853005672 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 471853005673 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 471853005674 putative active site [active] 471853005675 substrate binding site [chemical binding]; other site 471853005676 putative cosubstrate binding site; other site 471853005677 catalytic site [active] 471853005678 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 471853005679 substrate binding site [chemical binding]; other site 471853005680 16S rRNA methyltransferase B; Provisional; Region: PRK14902 471853005681 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 471853005682 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 471853005683 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 471853005684 substrate binding site [chemical binding]; other site 471853005685 hexamer interface [polypeptide binding]; other site 471853005686 metal binding site [ion binding]; metal-binding site 471853005687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853005688 NMT1-like family; Region: NMT1_2; cl15260 471853005689 NMT1/THI5 like; Region: NMT1; pfam09084 471853005690 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 471853005691 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 471853005692 ATP phosphoribosyltransferase; Region: HisG; cl15266 471853005693 HisG, C-terminal domain; Region: HisG_C; cl06867 471853005694 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 471853005695 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 471853005696 Protein of unknown function (DUF952); Region: DUF952; cl01393 471853005697 Predicted transcriptional regulator [Transcription]; Region: COG2378 471853005698 WYL domain; Region: WYL; cl14852 471853005699 Predicted transcriptional regulator [Transcription]; Region: COG2378 471853005700 WYL domain; Region: WYL; cl14852 471853005701 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 471853005702 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 471853005703 diacylglycerol kinase; Reviewed; Region: PRK11914 471853005704 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 471853005705 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471853005706 ATP binding site [chemical binding]; other site 471853005707 putative Mg++ binding site [ion binding]; other site 471853005708 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471853005709 nucleotide binding region [chemical binding]; other site 471853005710 ATP-binding site [chemical binding]; other site 471853005711 rRNA-processing arch domain; Region: rRNA_proc-arch; pfam13234 471853005712 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 471853005713 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 471853005714 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 471853005715 putative active site [active] 471853005716 catalytic triad [active] 471853005717 putative dimer interface [polypeptide binding]; other site 471853005718 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 471853005719 DXD motif; other site 471853005720 Putative Catalytic site; other site 471853005721 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 471853005722 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 471853005723 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 471853005724 nucleotide binding site/active site [active] 471853005725 HIT family signature motif; other site 471853005726 catalytic residue [active] 471853005727 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853005728 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471853005729 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853005730 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853005731 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 471853005732 Domain of unknown function (DUF385); Region: DUF385; cl04387 471853005733 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 471853005734 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 471853005735 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853005736 Walker A/P-loop; other site 471853005737 ATP binding site [chemical binding]; other site 471853005738 Q-loop/lid; other site 471853005739 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 471853005740 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853005741 Walker A/P-loop; other site 471853005742 ATP binding site [chemical binding]; other site 471853005743 Q-loop/lid; other site 471853005744 ABC transporter signature motif; other site 471853005745 Walker B; other site 471853005746 D-loop; other site 471853005747 H-loop/switch region; other site 471853005748 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 471853005749 DinB superfamily; Region: DinB_2; pfam12867 471853005750 Protein of unknown function (DUF796); Region: DUF796; cl01226 471853005751 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471853005752 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 471853005753 hydrophobic ligand binding site; other site 471853005754 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 471853005755 Helix-turn-helix domains; Region: HTH; cl00088 471853005756 SCP-2 sterol transfer family; Region: SCP2; cl01225 471853005757 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 471853005758 DinB superfamily; Region: DinB_2; pfam12867 471853005759 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 471853005760 aromatic arch; other site 471853005761 DCoH dimer interaction site [polypeptide binding]; other site 471853005762 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 471853005763 DCoH tetramer interaction site [polypeptide binding]; other site 471853005764 substrate binding site [chemical binding]; other site 471853005765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853005766 S-adenosylmethionine binding site [chemical binding]; other site 471853005767 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 471853005768 YCII-related domain; Region: YCII; cl00999 471853005769 YCII-related domain; Region: YCII; cl00999 471853005770 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 471853005771 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471853005772 TPR motif; other site 471853005773 binding surface 471853005774 AAA domain; Region: AAA_33; pfam13671 471853005775 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853005776 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 471853005777 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471853005778 Sulfatase; Region: Sulfatase; cl10460 471853005779 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 471853005780 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 471853005781 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471853005782 substrate binding site [chemical binding]; other site 471853005783 ATP binding site [chemical binding]; other site 471853005784 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471853005785 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471853005786 DNA binding residues [nucleotide binding] 471853005787 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471853005788 Bifunctional nuclease; Region: DNase-RNase; cl00553 471853005789 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 471853005790 DNA binding residues [nucleotide binding] 471853005791 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471853005792 phosphopeptide binding site; other site 471853005793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 471853005794 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 471853005795 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 471853005796 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 471853005797 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471853005798 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 471853005799 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 471853005800 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471853005801 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471853005802 active site 471853005803 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 471853005804 RNA/DNA hybrid binding site [nucleotide binding]; other site 471853005805 active site 471853005806 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 471853005807 DinB superfamily; Region: DinB_2; pfam12867 471853005808 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 471853005809 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 471853005810 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 471853005811 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 471853005812 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 471853005813 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 471853005814 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 471853005815 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 471853005816 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 471853005817 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 471853005818 CAAX protease self-immunity; Region: Abi; cl00558 471853005819 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 471853005820 PhoD-like phosphatase; Region: PhoD; pfam09423 471853005821 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 471853005822 putative active site [active] 471853005823 putative metal binding site [ion binding]; other site 471853005824 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471853005825 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 471853005826 The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins; Region: Luminal_IRE1_like; cl14874 471853005827 PQQ-like domain; Region: PQQ_2; pfam13360 471853005828 maltose O-acetyltransferase; Provisional; Region: PRK10092 471853005829 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 471853005830 active site 471853005831 substrate binding site [chemical binding]; other site 471853005832 trimer interface [polypeptide binding]; other site 471853005833 CoA binding site [chemical binding]; other site 471853005834 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 471853005835 Helix-turn-helix domains; Region: HTH; cl00088 471853005836 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 471853005837 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853005838 active site 471853005839 catalytic tetrad [active] 471853005840 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 471853005841 tellurite resistance protein TehB; Provisional; Region: PRK11207 471853005842 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853005843 S-adenosylmethionine binding site [chemical binding]; other site 471853005844 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471853005845 Carboxylesterase family; Region: COesterase; pfam00135 471853005846 substrate binding pocket [chemical binding]; other site 471853005847 catalytic triad [active] 471853005848 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 471853005849 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 471853005850 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853005851 Coenzyme A binding pocket [chemical binding]; other site 471853005852 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 471853005853 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 471853005854 conserved cys residue [active] 471853005855 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853005856 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853005857 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 471853005858 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 471853005859 Helix-turn-helix domains; Region: HTH; cl00088 471853005860 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853005861 RF-1 domain; Region: RF-1; cl02875 471853005862 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 471853005863 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471853005864 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 471853005865 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 471853005866 cofactor binding site; other site 471853005867 DNA binding site [nucleotide binding] 471853005868 substrate interaction site [chemical binding]; other site 471853005869 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471853005870 short chain dehydrogenase; Provisional; Region: PRK06114 471853005871 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853005872 NAD(P) binding site [chemical binding]; other site 471853005873 active site 471853005874 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 471853005875 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 471853005876 dimer interface [polypeptide binding]; other site 471853005877 active site 471853005878 catalytic residue [active] 471853005879 GTP-binding protein Der; Reviewed; Region: PRK03003 471853005880 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 471853005881 G1 box; other site 471853005882 GTP/Mg2+ binding site [chemical binding]; other site 471853005883 Switch I region; other site 471853005884 G2 box; other site 471853005885 Switch II region; other site 471853005886 G3 box; other site 471853005887 G4 box; other site 471853005888 G5 box; other site 471853005889 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 471853005890 G1 box; other site 471853005891 GTP/Mg2+ binding site [chemical binding]; other site 471853005892 Switch I region; other site 471853005893 G2 box; other site 471853005894 G3 box; other site 471853005895 Switch II region; other site 471853005896 G4 box; other site 471853005897 G5 box; other site 471853005898 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 471853005899 putative acyl-acceptor binding pocket; other site 471853005900 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 471853005901 CMP-binding site; other site 471853005902 The sites determining sugar specificity; other site 471853005903 prephenate dehydrogenase; Validated; Region: PRK06545 471853005904 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853005905 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 471853005906 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 471853005907 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471853005908 RNA binding surface [nucleotide binding]; other site 471853005909 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 471853005910 active site 471853005911 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 471853005912 ScpA/B protein; Region: ScpA_ScpB; cl00598 471853005913 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 471853005914 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471853005915 P-loop; other site 471853005916 Magnesium ion binding site [ion binding]; other site 471853005917 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471853005918 Magnesium ion binding site [ion binding]; other site 471853005919 Integral membrane protein TerC family; Region: TerC; cl10468 471853005920 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 471853005921 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 471853005922 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471853005923 DNA binding site [nucleotide binding] 471853005924 Int/Topo IB signature motif; other site 471853005925 active site 471853005926 UbiA prenyltransferase family; Region: UbiA; cl00337 471853005927 transketolase; Reviewed; Region: PRK05899 471853005928 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 471853005929 TPP-binding site [chemical binding]; other site 471853005930 dimer interface [polypeptide binding]; other site 471853005931 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 471853005932 PYR/PP interface [polypeptide binding]; other site 471853005933 dimer interface [polypeptide binding]; other site 471853005934 TPP binding site [chemical binding]; other site 471853005935 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471853005936 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 471853005937 putative active site [active] 471853005938 catalytic residue [active] 471853005939 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 471853005940 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 471853005941 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 471853005942 opcA protein; Region: OpcA; TIGR00534 471853005943 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 471853005944 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 471853005945 putative active site [active] 471853005946 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 471853005947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853005948 S-adenosylmethionine binding site [chemical binding]; other site 471853005949 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 471853005950 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 471853005951 substrate binding site [chemical binding]; other site 471853005952 dimer interface [polypeptide binding]; other site 471853005953 catalytic triad [active] 471853005954 Phosphoglycerate kinase; Region: PGK; pfam00162 471853005955 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 471853005956 substrate binding site [chemical binding]; other site 471853005957 hinge regions; other site 471853005958 ADP binding site [chemical binding]; other site 471853005959 catalytic site [active] 471853005960 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853005961 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 471853005962 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 471853005963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 471853005964 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 471853005965 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 471853005966 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 471853005967 phosphate binding site [ion binding]; other site 471853005968 putative substrate binding pocket [chemical binding]; other site 471853005969 dimer interface [polypeptide binding]; other site 471853005970 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 471853005971 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 471853005972 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 471853005973 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 471853005974 GIY-YIG motif/motif A; other site 471853005975 active site 471853005976 catalytic site [active] 471853005977 putative DNA binding site [nucleotide binding]; other site 471853005978 metal binding site [ion binding]; metal-binding site 471853005979 UvrB/uvrC motif; Region: UVR; pfam02151 471853005980 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 471853005981 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 471853005982 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 471853005983 putative catalytic site [active] 471853005984 putative metal binding site [ion binding]; other site 471853005985 putative phosphate binding site [ion binding]; other site 471853005986 OsmC-like protein; Region: OsmC; cl00767 471853005987 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 471853005988 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 471853005989 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 471853005990 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 471853005991 MOSC domain; Region: MOSC; pfam03473 471853005992 YCII-related domain; Region: YCII; cl00999 471853005993 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 471853005994 Membrane transport protein; Region: Mem_trans; cl09117 471853005995 Integral membrane protein TerC family; Region: TerC; cl10468 471853005996 Integral membrane protein TerC family; Region: TerC; cl10468 471853005997 excinuclease ABC subunit B; Provisional; Region: PRK05298 471853005998 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853005999 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471853006000 nucleotide binding region [chemical binding]; other site 471853006001 ATP-binding site [chemical binding]; other site 471853006002 Ultra-violet resistance protein B; Region: UvrB; pfam12344 471853006003 UvrB/uvrC motif; Region: UVR; pfam02151 471853006004 OsmC-like protein; Region: OsmC; cl00767 471853006005 uridine kinase; Validated; Region: PRK06696 471853006006 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853006007 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 471853006008 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 471853006009 CoA-binding site [chemical binding]; other site 471853006010 ATP-binding [chemical binding]; other site 471853006011 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 471853006012 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853006013 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853006014 active site 471853006015 phosphorylation site [posttranslational modification] 471853006016 intermolecular recognition site; other site 471853006017 dimerization interface [polypeptide binding]; other site 471853006018 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853006019 DNA binding residues [nucleotide binding] 471853006020 dimerization interface [polypeptide binding]; other site 471853006021 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471853006022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471853006023 ATP binding site [chemical binding]; other site 471853006024 Mg2+ binding site [ion binding]; other site 471853006025 G-X-G motif; other site 471853006026 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 471853006027 putative substrate binding pocket [chemical binding]; other site 471853006028 AC domain interface; other site 471853006029 catalytic triad [active] 471853006030 AB domain interface; other site 471853006031 interchain disulfide; other site 471853006032 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 471853006033 active site 471853006034 ADP-ribose binding site [chemical binding]; other site 471853006035 dimer interface [polypeptide binding]; other site 471853006036 nudix motif; other site 471853006037 metal binding site [ion binding]; metal-binding site 471853006038 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 471853006039 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 471853006040 RNA binding site [nucleotide binding]; other site 471853006041 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 471853006042 RNA binding site [nucleotide binding]; other site 471853006043 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 471853006044 RNA binding site [nucleotide binding]; other site 471853006045 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 471853006046 RNA binding site [nucleotide binding]; other site 471853006047 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 471853006048 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471853006049 Walker A/P-loop; other site 471853006050 ATP binding site [chemical binding]; other site 471853006051 Q-loop/lid; other site 471853006052 ABC transporter signature motif; other site 471853006053 Walker B; other site 471853006054 D-loop; other site 471853006055 H-loop/switch region; other site 471853006056 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853006057 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471853006058 Walker A/P-loop; other site 471853006059 ATP binding site [chemical binding]; other site 471853006060 Q-loop/lid; other site 471853006061 ABC transporter signature motif; other site 471853006062 Walker B; other site 471853006063 D-loop; other site 471853006064 H-loop/switch region; other site 471853006065 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853006066 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 471853006067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853006068 putative PBP binding loops; other site 471853006069 dimer interface [polypeptide binding]; other site 471853006070 ABC-ATPase subunit interface; other site 471853006071 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471853006072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853006073 dimer interface [polypeptide binding]; other site 471853006074 conserved gate region; other site 471853006075 putative PBP binding loops; other site 471853006076 ABC-ATPase subunit interface; other site 471853006077 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 471853006078 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471853006079 peptide binding site [polypeptide binding]; other site 471853006080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853006081 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 471853006082 DNA polymerase I; Provisional; Region: PRK05755 471853006083 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 471853006084 active site 471853006085 metal binding site 1 [ion binding]; metal-binding site 471853006086 putative 5' ssDNA interaction site; other site 471853006087 metal binding site 3; metal-binding site 471853006088 metal binding site 2 [ion binding]; metal-binding site 471853006089 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 471853006090 putative DNA binding site [nucleotide binding]; other site 471853006091 putative metal binding site [ion binding]; other site 471853006092 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 471853006093 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 471853006094 active site 471853006095 DNA binding site [nucleotide binding] 471853006096 catalytic site [active] 471853006097 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 471853006098 CoenzymeA binding site [chemical binding]; other site 471853006099 subunit interaction site [polypeptide binding]; other site 471853006100 PHB binding site; other site 471853006101 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 471853006102 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 471853006103 TM-ABC transporter signature motif; other site 471853006104 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 471853006105 TM-ABC transporter signature motif; other site 471853006106 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 471853006107 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 471853006108 Walker A/P-loop; other site 471853006109 ATP binding site [chemical binding]; other site 471853006110 Q-loop/lid; other site 471853006111 ABC transporter signature motif; other site 471853006112 Walker B; other site 471853006113 D-loop; other site 471853006114 H-loop/switch region; other site 471853006115 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 471853006116 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 471853006117 Walker A/P-loop; other site 471853006118 ATP binding site [chemical binding]; other site 471853006119 Q-loop/lid; other site 471853006120 ABC transporter signature motif; other site 471853006121 Walker B; other site 471853006122 D-loop; other site 471853006123 H-loop/switch region; other site 471853006124 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 471853006125 ligand binding site [chemical binding]; other site 471853006126 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 471853006127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853006128 active site 471853006129 phosphorylation site [posttranslational modification] 471853006130 intermolecular recognition site; other site 471853006131 dimerization interface [polypeptide binding]; other site 471853006132 ANTAR domain; Region: ANTAR; cl04297 471853006133 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 471853006134 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853006135 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 471853006136 YCII-related domain; Region: YCII; cl00999 471853006137 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471853006138 active site 471853006139 ATP binding site [chemical binding]; other site 471853006140 substrate binding site [chemical binding]; other site 471853006141 activation loop (A-loop); other site 471853006142 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 471853006143 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 471853006144 pyruvate kinase; Provisional; Region: PRK06247 471853006145 domain interfaces; other site 471853006146 active site 471853006147 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 471853006148 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853006149 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 471853006150 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 471853006151 active site 471853006152 dimer interface [polypeptide binding]; other site 471853006153 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 471853006154 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 471853006155 active site 471853006156 FMN binding site [chemical binding]; other site 471853006157 substrate binding site [chemical binding]; other site 471853006158 3Fe-4S cluster binding site [ion binding]; other site 471853006159 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 471853006160 domain interface; other site 471853006161 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 471853006162 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 471853006163 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 471853006164 substrate binding site [chemical binding]; other site 471853006165 active site 471853006166 catalytic residues [active] 471853006167 heterodimer interface [polypeptide binding]; other site 471853006168 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 471853006169 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 471853006170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853006171 catalytic residue [active] 471853006172 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 471853006173 active site 471853006174 ribulose/triose binding site [chemical binding]; other site 471853006175 phosphate binding site [ion binding]; other site 471853006176 substrate (anthranilate) binding pocket [chemical binding]; other site 471853006177 product (indole) binding pocket [chemical binding]; other site 471853006178 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 471853006179 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 471853006180 anthranilate synthase component I; Provisional; Region: PRK13571 471853006181 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 471853006182 chorismate binding enzyme; Region: Chorismate_bind; cl10555 471853006183 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 471853006184 TIGR03085 family protein; Region: TIGR03085 471853006185 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471853006186 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 471853006187 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853006188 Walker A/P-loop; other site 471853006189 ATP binding site [chemical binding]; other site 471853006190 Q-loop/lid; other site 471853006191 ABC transporter signature motif; other site 471853006192 Walker B; other site 471853006193 D-loop; other site 471853006194 H-loop/switch region; other site 471853006195 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471853006196 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853006197 Walker A/P-loop; other site 471853006198 ATP binding site [chemical binding]; other site 471853006199 Q-loop/lid; other site 471853006200 ABC transporter signature motif; other site 471853006201 Walker B; other site 471853006202 D-loop; other site 471853006203 H-loop/switch region; other site 471853006204 OsmC-like protein; Region: OsmC; cl00767 471853006205 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 471853006206 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471853006207 putative NAD(P) binding site [chemical binding]; other site 471853006208 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471853006209 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471853006210 non-specific DNA binding site [nucleotide binding]; other site 471853006211 salt bridge; other site 471853006212 sequence-specific DNA binding site [nucleotide binding]; other site 471853006213 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 471853006214 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 471853006215 substrate binding site [chemical binding]; other site 471853006216 glutamase interaction surface [polypeptide binding]; other site 471853006217 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 471853006218 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 471853006219 active site 471853006220 Pup-ligase protein; Region: Pup_ligase; cl15463 471853006221 Proteasome subunit beta type-5; Provisional; Region: PTZ00488 471853006222 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 471853006223 active site 471853006224 Pup-like protein; Region: Pup; cl05289 471853006225 Pup-ligase protein; Region: Pup_ligase; cl15463 471853006226 proteasome ATPase; Region: pup_AAA; TIGR03689 471853006227 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471853006228 Walker B motif; other site 471853006229 arginine finger; other site 471853006230 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 471853006231 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853006232 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 471853006233 active site 471853006234 putative substrate binding region [chemical binding]; other site 471853006235 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 471853006236 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853006237 motif II; other site 471853006238 PAC2 family; Region: PAC2; cl00847 471853006239 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471853006240 tRNA synthetases class I (C) catalytic domain; Region: tRNA-synt_1e; pfam01406 471853006241 active site 471853006242 HIGH motif; other site 471853006243 nucleotide binding site [chemical binding]; other site 471853006244 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471853006245 active site 471853006246 KMSKS motif; other site 471853006247 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 471853006248 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 471853006249 Bacitracin resistance protein BacA; Region: BacA; cl00858 471853006250 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 471853006251 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853006252 active site 471853006253 catalytic tetrad [active] 471853006254 hypothetical protein; Provisional; Region: PRK07906 471853006255 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 471853006256 putative metal binding site [ion binding]; other site 471853006257 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 471853006258 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 471853006259 active site 471853006260 Zn binding site [ion binding]; other site 471853006261 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 471853006262 YCII-related domain; Region: YCII; cl00999 471853006263 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 471853006264 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853006265 MFS/sugar transport protein; Region: MFS_2; pfam13347 471853006266 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 471853006267 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 471853006268 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 471853006269 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853006270 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853006271 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853006272 DNA binding site [nucleotide binding] 471853006273 domain linker motif; other site 471853006274 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853006275 dimerization interface [polypeptide binding]; other site 471853006276 ligand binding site [chemical binding]; other site 471853006277 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853006278 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853006279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853006280 putative PBP binding loops; other site 471853006281 dimer interface [polypeptide binding]; other site 471853006282 ABC-ATPase subunit interface; other site 471853006283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853006284 dimer interface [polypeptide binding]; other site 471853006285 conserved gate region; other site 471853006286 putative PBP binding loops; other site 471853006287 ABC-ATPase subunit interface; other site 471853006288 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 471853006289 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 471853006290 putative NAD(P) binding site [chemical binding]; other site 471853006291 catalytic Zn binding site [ion binding]; other site 471853006292 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853006293 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853006294 Peptidase family M23; Region: Peptidase_M23; pfam01551 471853006295 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 471853006296 active site 471853006297 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853006298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853006299 dimer interface [polypeptide binding]; other site 471853006300 conserved gate region; other site 471853006301 putative PBP binding loops; other site 471853006302 ABC-ATPase subunit interface; other site 471853006303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853006304 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853006305 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853006306 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853006307 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853006308 DNA binding site [nucleotide binding] 471853006309 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853006310 ligand binding site [chemical binding]; other site 471853006311 dimerization interface [polypeptide binding]; other site 471853006312 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 471853006313 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 471853006314 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471853006315 Predicted ATPase [General function prediction only]; Region: COG4637 471853006316 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853006317 Walker A/P-loop; other site 471853006318 ATP binding site [chemical binding]; other site 471853006319 Q-loop/lid; other site 471853006320 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 471853006321 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 471853006322 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 471853006323 motif I; other site 471853006324 active site 471853006325 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853006326 motif II; other site 471853006327 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471853006328 Domain of unknown function DUF20; Region: UPF0118; pfam01594 471853006329 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 471853006330 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 471853006331 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 471853006332 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 471853006333 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 471853006334 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 471853006335 generic binding surface I; other site 471853006336 generic binding surface II; other site 471853006337 Y-family of DNA polymerases; Region: PolY; cl12025 471853006338 active site 471853006339 DNA binding site [nucleotide binding] 471853006340 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 471853006341 substrate binding site [chemical binding]; other site 471853006342 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 471853006343 putative deacylase active site [active] 471853006344 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 471853006345 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 471853006346 FAD binding pocket [chemical binding]; other site 471853006347 FAD binding motif [chemical binding]; other site 471853006348 phosphate binding motif [ion binding]; other site 471853006349 NAD binding pocket [chemical binding]; other site 471853006350 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 471853006351 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 471853006352 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 471853006353 ABC-ATPase subunit interface; other site 471853006354 dimer interface [polypeptide binding]; other site 471853006355 putative PBP binding regions; other site 471853006356 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 471853006357 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 471853006358 siderophore binding site; other site 471853006359 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 471853006360 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 471853006361 Walker A/P-loop; other site 471853006362 ATP binding site [chemical binding]; other site 471853006363 Q-loop/lid; other site 471853006364 ABC transporter signature motif; other site 471853006365 Walker B; other site 471853006366 D-loop; other site 471853006367 H-loop/switch region; other site 471853006368 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 471853006369 Flavin Reductases; Region: FlaRed; cl00801 471853006370 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 471853006371 homotrimer interaction site [polypeptide binding]; other site 471853006372 putative active site [active] 471853006373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853006374 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 471853006375 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 471853006376 Walker A/P-loop; other site 471853006377 ATP binding site [chemical binding]; other site 471853006378 Q-loop/lid; other site 471853006379 ABC transporter signature motif; other site 471853006380 Walker B; other site 471853006381 D-loop; other site 471853006382 H-loop/switch region; other site 471853006383 NIL domain; Region: NIL; cl09633 471853006384 NMT1-like family; Region: NMT1_2; cl15260 471853006385 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853006386 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 471853006387 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471853006388 Helix-turn-helix domains; Region: HTH; cl00088 471853006389 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853006390 Coenzyme A binding pocket [chemical binding]; other site 471853006391 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 471853006392 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 471853006393 Helix-turn-helix domains; Region: HTH; cl00088 471853006394 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 471853006395 Protein of unknown function (DUF998); Region: DUF998; pfam06197 471853006396 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471853006397 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 471853006398 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 471853006399 Walker A/P-loop; other site 471853006400 ATP binding site [chemical binding]; other site 471853006401 Q-loop/lid; other site 471853006402 ABC transporter signature motif; other site 471853006403 Walker B; other site 471853006404 D-loop; other site 471853006405 H-loop/switch region; other site 471853006406 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471853006407 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 471853006408 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853006409 Walker A/P-loop; other site 471853006410 ATP binding site [chemical binding]; other site 471853006411 Q-loop/lid; other site 471853006412 ABC transporter signature motif; other site 471853006413 Walker B; other site 471853006414 D-loop; other site 471853006415 H-loop/switch region; other site 471853006416 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 471853006417 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 471853006418 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 471853006419 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853006420 Walker A/P-loop; other site 471853006421 ATP binding site [chemical binding]; other site 471853006422 Q-loop/lid; other site 471853006423 ABC transporter signature motif; other site 471853006424 Walker B; other site 471853006425 D-loop; other site 471853006426 H-loop/switch region; other site 471853006427 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 471853006428 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 471853006429 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 471853006430 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 471853006431 ligand binding site; other site 471853006432 oligomer interface; other site 471853006433 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 471853006434 sulfate 1 binding site; other site 471853006435 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853006436 motif II; other site 471853006437 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471853006438 catalytic core [active] 471853006439 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 471853006440 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853006441 NAD(P) binding site [chemical binding]; other site 471853006442 active site 471853006443 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853006444 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 471853006445 NAD(P) binding site [chemical binding]; other site 471853006446 active site 471853006447 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 471853006448 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 471853006449 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471853006450 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853006451 Walker A/P-loop; other site 471853006452 ATP binding site [chemical binding]; other site 471853006453 Q-loop/lid; other site 471853006454 ABC transporter signature motif; other site 471853006455 Walker B; other site 471853006456 D-loop; other site 471853006457 H-loop/switch region; other site 471853006458 ABC transporter; Region: ABC_tran_2; pfam12848 471853006459 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 471853006460 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853006461 Helix-turn-helix domains; Region: HTH; cl00088 471853006462 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 471853006463 putative dimer interface [polypeptide binding]; other site 471853006464 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 471853006465 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 471853006466 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 471853006467 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 471853006468 Domain of unknown function (DUF222); Region: DUF222; pfam02720 471853006469 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 471853006470 active site 471853006471 Domain of unknown function DUF59; Region: DUF59; cl00941 471853006472 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 471853006473 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 471853006474 trimerization site [polypeptide binding]; other site 471853006475 active site 471853006476 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 471853006477 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 471853006478 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471853006479 catalytic residue [active] 471853006480 FeS assembly ATPase SufC; Region: sufC; TIGR01978 471853006481 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 471853006482 Walker A/P-loop; other site 471853006483 ATP binding site [chemical binding]; other site 471853006484 Q-loop/lid; other site 471853006485 ABC transporter signature motif; other site 471853006486 Walker B; other site 471853006487 D-loop; other site 471853006488 H-loop/switch region; other site 471853006489 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 471853006490 [2Fe-2S] cluster binding site [ion binding]; other site 471853006491 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 471853006492 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 471853006493 FeS assembly protein SufB; Region: sufB; TIGR01980 471853006494 Predicted transcriptional regulator [Transcription]; Region: COG2345 471853006495 Helix-turn-helix domains; Region: HTH; cl00088 471853006496 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471853006497 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 471853006498 Walker A/P-loop; other site 471853006499 ATP binding site [chemical binding]; other site 471853006500 Q-loop/lid; other site 471853006501 ABC transporter signature motif; other site 471853006502 Walker B; other site 471853006503 D-loop; other site 471853006504 H-loop/switch region; other site 471853006505 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 471853006506 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853006507 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 471853006508 NAD(P) binding site [chemical binding]; other site 471853006509 active site 471853006510 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 471853006511 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 471853006512 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 471853006513 dimer interface [polypeptide binding]; other site 471853006514 ADP-ribose binding site [chemical binding]; other site 471853006515 active site 471853006516 nudix motif; other site 471853006517 metal binding site [ion binding]; metal-binding site 471853006518 CTP synthetase; Validated; Region: pyrG; PRK05380 471853006519 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 471853006520 Catalytic site [active] 471853006521 active site 471853006522 UTP binding site [chemical binding]; other site 471853006523 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 471853006524 active site 471853006525 putative oxyanion hole; other site 471853006526 catalytic triad [active] 471853006527 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471853006528 MviN-like protein; Region: MVIN; pfam03023 471853006529 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 471853006530 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 471853006531 Thiamine pyrophosphokinase; Region: TPK; cl08415 471853006532 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 471853006533 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 471853006534 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853006535 Walker A/P-loop; other site 471853006536 ATP binding site [chemical binding]; other site 471853006537 Q-loop/lid; other site 471853006538 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853006539 ABC transporter signature motif; other site 471853006540 Walker B; other site 471853006541 D-loop; other site 471853006542 H-loop/switch region; other site 471853006543 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 471853006544 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 471853006545 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 471853006546 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 471853006547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 471853006548 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 471853006549 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 471853006550 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 471853006551 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 471853006552 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 471853006553 active site 471853006554 HIGH motif; other site 471853006555 dimer interface [polypeptide binding]; other site 471853006556 KMSKS motif; other site 471853006557 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 471853006558 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 471853006559 active site 471853006560 DNA binding site [nucleotide binding] 471853006561 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853006562 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853006563 argininosuccinate lyase; Provisional; Region: PRK00855 471853006564 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 471853006565 active sites [active] 471853006566 tetramer interface [polypeptide binding]; other site 471853006567 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 471853006568 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 471853006569 ANP binding site [chemical binding]; other site 471853006570 Substrate Binding Site II [chemical binding]; other site 471853006571 Substrate Binding Site I [chemical binding]; other site 471853006572 arginine repressor; Provisional; Region: PRK03341 471853006573 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 471853006574 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 471853006575 ornithine carbamoyltransferase; Provisional; Region: PRK00779 471853006576 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 471853006577 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853006578 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 471853006579 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471853006580 inhibitor-cofactor binding pocket; inhibition site 471853006581 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853006582 catalytic residue [active] 471853006583 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 471853006584 feedback inhibition sensing region; other site 471853006585 homohexameric interface [polypeptide binding]; other site 471853006586 nucleotide binding site [chemical binding]; other site 471853006587 N-acetyl-L-glutamate binding site [chemical binding]; other site 471853006588 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 471853006589 heterotetramer interface [polypeptide binding]; other site 471853006590 active site pocket [active] 471853006591 cleavage site 471853006592 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 471853006593 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853006594 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 471853006595 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 471853006596 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 471853006597 NADP binding site [chemical binding]; other site 471853006598 dimer interface [polypeptide binding]; other site 471853006599 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 471853006600 classical (c) SDRs; Region: SDR_c; cd05233 471853006601 NAD(P) binding site [chemical binding]; other site 471853006602 active site 471853006603 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 471853006604 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 471853006605 putative tRNA-binding site [nucleotide binding]; other site 471853006606 B3/4 domain; Region: B3_4; cl11458 471853006607 tRNA synthetase B5 domain; Region: B5; cl08394 471853006608 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 471853006609 motif 1; other site 471853006610 dimer interface [polypeptide binding]; other site 471853006611 active site 471853006612 motif 2; other site 471853006613 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 471853006614 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 471853006615 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 471853006616 dimer interface [polypeptide binding]; other site 471853006617 motif 1; other site 471853006618 active site 471853006619 motif 2; other site 471853006620 motif 3; other site 471853006621 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 471853006622 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471853006623 active site 471853006624 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 471853006625 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 471853006626 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 471853006627 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 471853006628 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 471853006629 ribosomal protein L20; Region: rpl20; CHL00068 471853006630 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 471853006631 23S rRNA binding site [nucleotide binding]; other site 471853006632 L21 binding site [polypeptide binding]; other site 471853006633 L13 binding site [polypeptide binding]; other site 471853006634 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 471853006635 translation initiation factor IF-3; Region: infC; TIGR00168 471853006636 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 471853006637 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 471853006638 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 471853006639 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 471853006640 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 471853006641 catalytic residues [active] 471853006642 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 471853006643 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 471853006644 putative active site [active] 471853006645 oxyanion strand; other site 471853006646 catalytic triad [active] 471853006647 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 471853006648 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 471853006649 putative active site pocket [active] 471853006650 4-fold oligomerization interface [polypeptide binding]; other site 471853006651 metal binding residues [ion binding]; metal-binding site 471853006652 3-fold/trimer interface [polypeptide binding]; other site 471853006653 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 471853006654 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471853006655 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853006656 homodimer interface [polypeptide binding]; other site 471853006657 catalytic residue [active] 471853006658 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471853006659 ATP binding site [chemical binding]; other site 471853006660 putative Mg++ binding site [ion binding]; other site 471853006661 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471853006662 nucleotide binding region [chemical binding]; other site 471853006663 ATP-binding site [chemical binding]; other site 471853006664 PspC domain; Region: PspC; cl00864 471853006665 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853006666 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 471853006667 histidinol dehydrogenase; Region: hisD; TIGR00069 471853006668 NAD binding site [chemical binding]; other site 471853006669 dimerization interface [polypeptide binding]; other site 471853006670 product binding site; other site 471853006671 substrate binding site [chemical binding]; other site 471853006672 zinc binding site [ion binding]; other site 471853006673 catalytic residues [active] 471853006674 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 471853006675 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 471853006676 nudix motif; other site 471853006677 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 471853006678 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 471853006679 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 471853006680 generic binding surface II; other site 471853006681 generic binding surface I; other site 471853006682 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853006683 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 471853006684 active site 471853006685 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 471853006686 DivIVA domain; Region: DivI1A_domain; TIGR03544 471853006687 Plant ATP synthase F0; Region: YMF19; cl07975 471853006688 Protein of unknown function (DUF552); Region: DUF552; cl00775 471853006689 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 471853006690 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 471853006691 cell division protein FtsZ; Validated; Region: PRK09330 471853006692 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 471853006693 nucleotide binding site [chemical binding]; other site 471853006694 SulA interaction site; other site 471853006695 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 471853006696 Cell division protein FtsQ; Region: FtsQ; pfam03799 471853006697 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 471853006698 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 471853006699 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471853006700 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471853006701 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 471853006702 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 471853006703 active site 471853006704 homodimer interface [polypeptide binding]; other site 471853006705 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 471853006706 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 471853006707 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471853006708 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 471853006709 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 471853006710 Mg++ binding site [ion binding]; other site 471853006711 putative catalytic motif [active] 471853006712 putative substrate binding site [chemical binding]; other site 471853006713 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 471853006714 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 471853006715 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471853006716 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471853006717 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 471853006718 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471853006719 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471853006720 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 471853006721 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 471853006722 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 471853006723 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 471853006724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853006725 cell division protein MraZ; Reviewed; Region: PRK00326 471853006726 MraZ protein; Region: MraZ; pfam02381 471853006727 MraZ protein; Region: MraZ; pfam02381 471853006728 MoxR-like ATPases [General function prediction only]; Region: COG0714 471853006729 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471853006730 ATP binding site [chemical binding]; other site 471853006731 Walker A motif; other site 471853006732 Walker B motif; other site 471853006733 arginine finger; other site 471853006734 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 471853006735 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471853006736 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 471853006737 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 471853006738 DNA polymerase IV; Validated; Region: PRK03858 471853006739 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 471853006740 active site 471853006741 DNA binding site [nucleotide binding] 471853006742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 471853006743 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 471853006744 DNA-binding site [nucleotide binding]; DNA binding site 471853006745 RNA-binding motif; other site 471853006746 PAC2 family; Region: PAC2; cl00847 471853006747 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 471853006748 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853006749 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 471853006750 Family description; Region: UvrD_C_2; cl15862 471853006751 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 471853006752 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853006753 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 471853006754 L-serine binding site [chemical binding]; other site 471853006755 ACT domain interface; other site 471853006756 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 471853006757 ATP cone domain; Region: ATP-cone; pfam03477 471853006758 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 471853006759 putative peptidoglycan binding site; other site 471853006760 LexA repressor; Validated; Region: PRK00215 471853006761 Helix-turn-helix domains; Region: HTH; cl00088 471853006762 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 471853006763 Catalytic site [active] 471853006764 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 471853006765 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 471853006766 NAD binding site [chemical binding]; other site 471853006767 dimer interface [polypeptide binding]; other site 471853006768 substrate binding site [chemical binding]; other site 471853006769 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471853006770 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 471853006771 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853006772 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853006773 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 471853006774 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 471853006775 HflX GTPase family; Region: HflX; cd01878 471853006776 G1 box; other site 471853006777 GTP/Mg2+ binding site [chemical binding]; other site 471853006778 Switch I region; other site 471853006779 G2 box; other site 471853006780 G3 box; other site 471853006781 Switch II region; other site 471853006782 G4 box; other site 471853006783 G5 box; other site 471853006784 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853006785 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 471853006786 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 471853006787 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 471853006788 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 471853006789 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853006790 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 471853006791 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 471853006792 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 471853006793 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 471853006794 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 471853006795 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 471853006796 Walker A/P-loop; other site 471853006797 ATP binding site [chemical binding]; other site 471853006798 Q-loop/lid; other site 471853006799 ABC transporter signature motif; other site 471853006800 Walker B; other site 471853006801 D-loop; other site 471853006802 H-loop/switch region; other site 471853006803 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 471853006804 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 471853006805 substrate binding pocket [chemical binding]; other site 471853006806 membrane-bound complex binding site; other site 471853006807 hinge residues; other site 471853006808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853006809 dimer interface [polypeptide binding]; other site 471853006810 conserved gate region; other site 471853006811 ABC-ATPase subunit interface; other site 471853006812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853006813 dimer interface [polypeptide binding]; other site 471853006814 conserved gate region; other site 471853006815 putative PBP binding loops; other site 471853006816 ABC-ATPase subunit interface; other site 471853006817 RecX family; Region: RecX; cl00936 471853006818 recombinase A; Provisional; Region: recA; PRK09354 471853006819 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 471853006820 hexamer interface [polypeptide binding]; other site 471853006821 Walker A motif; other site 471853006822 ATP binding site [chemical binding]; other site 471853006823 Walker B motif; other site 471853006824 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853006825 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853006826 active site 471853006827 phosphorylation site [posttranslational modification] 471853006828 intermolecular recognition site; other site 471853006829 dimerization interface [polypeptide binding]; other site 471853006830 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853006831 DNA binding residues [nucleotide binding] 471853006832 dimerization interface [polypeptide binding]; other site 471853006833 Histidine kinase; Region: HisKA_3; pfam07730 471853006834 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471853006835 Pectinacetylesterase; Region: PAE; pfam03283 471853006836 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 471853006837 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471853006838 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 471853006839 ATP binding site [chemical binding]; other site 471853006840 putative Mg++ binding site [ion binding]; other site 471853006841 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471853006842 nucleotide binding region [chemical binding]; other site 471853006843 ATP-binding site [chemical binding]; other site 471853006844 DEAD/H associated; Region: DEAD_assoc; pfam08494 471853006845 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 471853006846 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 471853006847 putative DNA binding site [nucleotide binding]; other site 471853006848 catalytic residue [active] 471853006849 putative H2TH interface [polypeptide binding]; other site 471853006850 putative catalytic residues [active] 471853006851 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 471853006852 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471853006853 non-specific DNA binding site [nucleotide binding]; other site 471853006854 salt bridge; other site 471853006855 sequence-specific DNA binding site [nucleotide binding]; other site 471853006856 Competence-damaged protein; Region: CinA; cl00666 471853006857 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 471853006858 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 471853006859 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 471853006860 putative active site [active] 471853006861 putative metal binding site [ion binding]; other site 471853006862 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 471853006863 Sulfatase; Region: Sulfatase; cl10460 471853006864 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471853006865 active site 471853006866 metal binding site [ion binding]; metal-binding site 471853006867 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 471853006868 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 471853006869 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853006870 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 471853006871 Helix-turn-helix domains; Region: HTH; cl00088 471853006872 WHG domain; Region: WHG; pfam13305 471853006873 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 471853006874 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471853006875 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 471853006876 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 471853006877 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 471853006878 dimer interface [polypeptide binding]; other site 471853006879 active site 471853006880 catalytic residue [active] 471853006881 AzlC protein; Region: AzlC; cl00570 471853006882 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853006883 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 471853006884 dihydrodipicolinate reductase; Provisional; Region: PRK00048 471853006885 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853006886 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 471853006887 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 471853006888 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 471853006889 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471853006890 classical (c) SDRs; Region: SDR_c; cd05233 471853006891 NAD(P) binding site [chemical binding]; other site 471853006892 active site 471853006893 H+ Antiporter protein; Region: 2A0121; TIGR00900 471853006894 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853006895 putative substrate translocation pore; other site 471853006896 Helix-turn-helix domains; Region: HTH; cl00088 471853006897 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 471853006898 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853006899 dimerization interface [polypeptide binding]; other site 471853006900 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 471853006901 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 471853006902 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471853006903 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 471853006904 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 471853006905 oligomer interface [polypeptide binding]; other site 471853006906 RNA binding site [nucleotide binding]; other site 471853006907 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 471853006908 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 471853006909 RNase E interface [polypeptide binding]; other site 471853006910 trimer interface [polypeptide binding]; other site 471853006911 active site 471853006912 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 471853006913 putative nucleic acid binding region [nucleotide binding]; other site 471853006914 G-X-X-G motif; other site 471853006915 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 471853006916 RNA binding site [nucleotide binding]; other site 471853006917 domain interface; other site 471853006918 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 471853006919 16S/18S rRNA binding site [nucleotide binding]; other site 471853006920 S13e-L30e interaction site [polypeptide binding]; other site 471853006921 25S rRNA binding site [nucleotide binding]; other site 471853006922 tetracycline repressor protein TetR; Provisional; Region: PRK13756 471853006923 Helix-turn-helix domains; Region: HTH; cl00088 471853006924 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853006925 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853006926 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853006927 active site 471853006928 phosphorylation site [posttranslational modification] 471853006929 intermolecular recognition site; other site 471853006930 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853006931 dimerization interface [polypeptide binding]; other site 471853006932 DNA binding residues [nucleotide binding] 471853006933 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471853006934 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471853006935 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471853006936 FtsX-like permease family; Region: FtsX; cl15850 471853006937 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471853006938 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 471853006939 Walker A/P-loop; other site 471853006940 ATP binding site [chemical binding]; other site 471853006941 Q-loop/lid; other site 471853006942 ABC transporter signature motif; other site 471853006943 Walker B; other site 471853006944 D-loop; other site 471853006945 H-loop/switch region; other site 471853006946 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 471853006947 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 471853006948 active site 471853006949 Riboflavin kinase; Region: Flavokinase; cl03312 471853006950 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 471853006951 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 471853006952 RNA binding site [nucleotide binding]; other site 471853006953 active site 471853006954 Ribosome-binding factor A; Region: RBFA; cl00542 471853006955 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 471853006956 translation initiation factor IF-2; Region: IF-2; TIGR00487 471853006957 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 471853006958 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 471853006959 G1 box; other site 471853006960 putative GEF interaction site [polypeptide binding]; other site 471853006961 GTP/Mg2+ binding site [chemical binding]; other site 471853006962 Switch I region; other site 471853006963 G2 box; other site 471853006964 G3 box; other site 471853006965 Switch II region; other site 471853006966 G4 box; other site 471853006967 G5 box; other site 471853006968 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 471853006969 Translation-initiation factor 2; Region: IF-2; pfam11987 471853006970 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 471853006971 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 471853006972 putative RNA binding cleft [nucleotide binding]; other site 471853006973 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 471853006974 NusA N-terminal domain; Region: NusA_N; pfam08529 471853006975 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 471853006976 RNA binding site [nucleotide binding]; other site 471853006977 homodimer interface [polypeptide binding]; other site 471853006978 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 471853006979 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 471853006980 G-X-X-G motif; other site 471853006981 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 471853006982 ribosome maturation protein RimP; Reviewed; Region: PRK00092 471853006983 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 471853006984 Sm1 motif; other site 471853006985 D3 - B interaction site; other site 471853006986 D1 - D2 interaction site; other site 471853006987 Hfq - Hfq interaction site; other site 471853006988 RNA binding pocket [nucleotide binding]; other site 471853006989 Sm2 motif; other site 471853006990 prolyl-tRNA synthetase; Provisional; Region: PRK09194 471853006991 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 471853006992 dimer interface [polypeptide binding]; other site 471853006993 motif 1; other site 471853006994 active site 471853006995 motif 2; other site 471853006996 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 471853006997 putative deacylase active site [active] 471853006998 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 471853006999 active site 471853007000 motif 3; other site 471853007001 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 471853007002 anticodon binding site; other site 471853007003 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 471853007004 homotrimer interaction site [polypeptide binding]; other site 471853007005 putative active site [active] 471853007006 Helix-turn-helix domains; Region: HTH; cl00088 471853007007 WYL domain; Region: WYL; cl14852 471853007008 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 471853007009 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853007010 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 471853007011 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 471853007012 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 471853007013 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 471853007014 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 471853007015 active site 471853007016 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 471853007017 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 471853007018 putative substrate binding region [chemical binding]; other site 471853007019 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 471853007020 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 471853007021 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 471853007022 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 471853007023 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 471853007024 DivIVA domain; Region: DivI1A_domain; TIGR03544 471853007025 DivIVA domain; Region: DivI1A_domain; TIGR03544 471853007026 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 471853007027 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471853007028 FeS/SAM binding site; other site 471853007029 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 471853007030 ribosome recycling factor; Reviewed; Region: frr; PRK00083 471853007031 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 471853007032 hinge region; other site 471853007033 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 471853007034 putative nucleotide binding site [chemical binding]; other site 471853007035 uridine monophosphate binding site [chemical binding]; other site 471853007036 homohexameric interface [polypeptide binding]; other site 471853007037 elongation factor Ts; Provisional; Region: tsf; PRK09377 471853007038 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 471853007039 Elongation factor TS; Region: EF_TS; pfam00889 471853007040 Elongation factor TS; Region: EF_TS; pfam00889 471853007041 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 471853007042 rRNA interaction site [nucleotide binding]; other site 471853007043 S8 interaction site; other site 471853007044 putative laminin-1 binding site; other site 471853007045 Peptidase family M23; Region: Peptidase_M23; pfam01551 471853007046 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 471853007047 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471853007048 DNA binding site [nucleotide binding] 471853007049 Int/Topo IB signature motif; other site 471853007050 active site 471853007051 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 471853007052 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 471853007053 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 471853007054 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 471853007055 catalytic residues [active] 471853007056 catalytic nucleophile [active] 471853007057 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 471853007058 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 471853007059 polymerase nucleotide-binding site; other site 471853007060 DNA-binding residues [nucleotide binding]; DNA binding site 471853007061 nucleotide binding site [chemical binding]; other site 471853007062 primase nucleotide-binding site [nucleotide binding]; other site 471853007063 AAA domain; Region: AAA_25; pfam13481 471853007064 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 471853007065 Restriction endonuclease; Region: Mrr_cat; cl00516 471853007066 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 471853007067 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 471853007068 RNA/DNA hybrid binding site [nucleotide binding]; other site 471853007069 active site 471853007070 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 471853007071 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 471853007072 Catalytic site [active] 471853007073 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 471853007074 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 471853007075 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853007076 RimM N-terminal domain; Region: RimM; pfam01782 471853007077 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 471853007078 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 471853007079 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 471853007080 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 471853007081 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 471853007082 signal recognition particle protein; Provisional; Region: PRK10867 471853007083 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 471853007084 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 471853007085 P loop; other site 471853007086 GTP binding site [chemical binding]; other site 471853007087 Signal peptide binding domain; Region: SRP_SPB; pfam02978 471853007088 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 471853007089 metal binding triad; other site 471853007090 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 471853007091 PII uridylyl-transferase; Provisional; Region: glnD; PRK01759 471853007092 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 471853007093 Nitrogen regulatory protein P-II; Region: P-II; cl00412 471853007094 Nitrogen regulatory protein P-II; Region: P-II; smart00938 471853007095 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 471853007096 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 471853007097 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853007098 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 471853007099 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 471853007100 Walker A/P-loop; other site 471853007101 ATP binding site [chemical binding]; other site 471853007102 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 471853007103 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 471853007104 ABC transporter signature motif; other site 471853007105 Walker B; other site 471853007106 D-loop; other site 471853007107 H-loop/switch region; other site 471853007108 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853007109 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853007110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007111 dimer interface [polypeptide binding]; other site 471853007112 conserved gate region; other site 471853007113 putative PBP binding loops; other site 471853007114 ABC-ATPase subunit interface; other site 471853007115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007116 dimer interface [polypeptide binding]; other site 471853007117 conserved gate region; other site 471853007118 putative PBP binding loops; other site 471853007119 ABC-ATPase subunit interface; other site 471853007120 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 471853007121 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853007122 Walker A/P-loop; other site 471853007123 ATP binding site [chemical binding]; other site 471853007124 Q-loop/lid; other site 471853007125 ABC transporter signature motif; other site 471853007126 Walker B; other site 471853007127 D-loop; other site 471853007128 H-loop/switch region; other site 471853007129 TOBE domain; Region: TOBE_2; cl01440 471853007130 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 471853007131 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 471853007132 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 471853007133 active site 471853007134 multimer interface [polypeptide binding]; other site 471853007135 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 471853007136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853007137 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471853007138 putative substrate translocation pore; other site 471853007139 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853007140 Helix-turn-helix domains; Region: HTH; cl00088 471853007141 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 471853007142 DAK2 domain; Region: Dak2; cl03685 471853007143 Helix-turn-helix domains; Region: HTH; cl00088 471853007144 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 471853007145 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853007146 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 471853007147 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471853007148 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 471853007149 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 471853007150 HIGH motif; other site 471853007151 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 471853007152 active site 471853007153 KMSKS motif; other site 471853007154 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 471853007155 tRNA binding surface [nucleotide binding]; other site 471853007156 anticodon binding site; other site 471853007157 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 471853007158 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 471853007159 nucleotide binding site/active site [active] 471853007160 HIT family signature motif; other site 471853007161 catalytic residue [active] 471853007162 Domain of unknown function (DUF222); Region: DUF222; pfam02720 471853007163 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 471853007164 active site 471853007165 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853007166 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 471853007167 NAD(P) binding site [chemical binding]; other site 471853007168 active site 471853007169 hypothetical protein; Provisional; Region: PRK06062 471853007170 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471853007171 inhibitor-cofactor binding pocket; inhibition site 471853007172 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853007173 catalytic residue [active] 471853007174 NMT1/THI5 like; Region: NMT1; pfam09084 471853007175 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853007176 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 471853007177 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 471853007178 Walker A/P-loop; other site 471853007179 ATP binding site [chemical binding]; other site 471853007180 Q-loop/lid; other site 471853007181 ABC transporter signature motif; other site 471853007182 Walker B; other site 471853007183 D-loop; other site 471853007184 H-loop/switch region; other site 471853007185 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853007186 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 471853007187 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471853007188 phenylhydantoinase; Validated; Region: PRK08323 471853007189 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 471853007190 tetramer interface [polypeptide binding]; other site 471853007191 active site 471853007192 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 471853007193 N-carbamolyputrescine amidase; Region: PLN02747 471853007194 active site 471853007195 catalytic triad [active] 471853007196 dimer interface [polypeptide binding]; other site 471853007197 putative transporter; Provisional; Region: PRK11021 471853007198 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853007199 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471853007200 active site 471853007201 catalytic tetrad [active] 471853007202 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 471853007203 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 471853007204 intersubunit interface [polypeptide binding]; other site 471853007205 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471853007206 ABC-ATPase subunit interface; other site 471853007207 dimer interface [polypeptide binding]; other site 471853007208 putative PBP binding regions; other site 471853007209 proposed F420-0 ABC transporter, ATP-binding protein; Region: F420-0_ABC_ATP; TIGR03873 471853007210 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 471853007211 Walker A/P-loop; other site 471853007212 ATP binding site [chemical binding]; other site 471853007213 Q-loop/lid; other site 471853007214 ABC transporter signature motif; other site 471853007215 Walker B; other site 471853007216 D-loop; other site 471853007217 H-loop/switch region; other site 471853007218 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 471853007219 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 471853007220 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471853007221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853007222 NAD(P) binding site [chemical binding]; other site 471853007223 LDH/MDH dimer interface [polypeptide binding]; other site 471853007224 substrate binding site [chemical binding]; other site 471853007225 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471853007226 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 471853007227 substrate binding site [chemical binding]; other site 471853007228 ATP binding site [chemical binding]; other site 471853007229 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 471853007230 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853007231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853007232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007233 dimer interface [polypeptide binding]; other site 471853007234 conserved gate region; other site 471853007235 putative PBP binding loops; other site 471853007236 ABC-ATPase subunit interface; other site 471853007237 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 471853007238 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471853007239 active site 471853007240 HIGH motif; other site 471853007241 nucleotide binding site [chemical binding]; other site 471853007242 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471853007243 active site 471853007244 KMSKS motif; other site 471853007245 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 471853007246 tRNA binding surface [nucleotide binding]; other site 471853007247 anticodon binding site; other site 471853007248 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 471853007249 AMP-binding enzyme; Region: AMP-binding; cl15778 471853007250 Chorismate mutase type II; Region: CM_2; cl00693 471853007251 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 471853007252 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 471853007253 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853007254 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471853007255 Walker A motif; other site 471853007256 ATP binding site [chemical binding]; other site 471853007257 Walker B motif; other site 471853007258 arginine finger; other site 471853007259 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 471853007260 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 471853007261 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 471853007262 oligomer interface [polypeptide binding]; other site 471853007263 active site residues [active] 471853007264 Clp protease; Region: CLP_protease; pfam00574 471853007265 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 471853007266 oligomer interface [polypeptide binding]; other site 471853007267 active site residues [active] 471853007268 trigger factor; Provisional; Region: tig; PRK01490 471853007269 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 471853007270 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 471853007271 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471853007272 Sulfatase; Region: Sulfatase; cl10460 471853007273 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853007274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007275 dimer interface [polypeptide binding]; other site 471853007276 conserved gate region; other site 471853007277 putative PBP binding loops; other site 471853007278 ABC-ATPase subunit interface; other site 471853007279 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853007280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007281 putative PBP binding loops; other site 471853007282 dimer interface [polypeptide binding]; other site 471853007283 ABC-ATPase subunit interface; other site 471853007284 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853007285 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853007286 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853007287 DNA binding site [nucleotide binding] 471853007288 domain linker motif; other site 471853007289 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853007290 ligand binding site [chemical binding]; other site 471853007291 dimerization interface [polypeptide binding]; other site 471853007292 Cupin domain; Region: Cupin_2; cl09118 471853007293 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 471853007294 hydrophobic ligand binding site; other site 471853007295 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471853007296 active site 471853007297 ATP binding site [chemical binding]; other site 471853007298 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 471853007299 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 471853007300 dimer interface [polypeptide binding]; other site 471853007301 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853007302 catalytic residue [active] 471853007303 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 471853007304 serine O-acetyltransferase; Region: cysE; TIGR01172 471853007305 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 471853007306 trimer interface [polypeptide binding]; other site 471853007307 active site 471853007308 substrate binding site [chemical binding]; other site 471853007309 CoA binding site [chemical binding]; other site 471853007310 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 471853007311 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 471853007312 multifunctional aminopeptidase A; Provisional; Region: PRK00913 471853007313 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 471853007314 interface (dimer of trimers) [polypeptide binding]; other site 471853007315 Substrate-binding/catalytic site; other site 471853007316 Zn-binding sites [ion binding]; other site 471853007317 Domain of unknown function DUF20; Region: UPF0118; pfam01594 471853007318 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 471853007319 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 471853007320 putative DNA binding site [nucleotide binding]; other site 471853007321 catalytic residue [active] 471853007322 putative H2TH interface [polypeptide binding]; other site 471853007323 putative catalytic residues [active] 471853007324 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 471853007325 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 471853007326 DNA binding site [nucleotide binding] 471853007327 active site 471853007328 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 471853007329 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 471853007330 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 471853007331 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 471853007332 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 471853007333 active site 471853007334 Zn binding site [ion binding]; other site 471853007335 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 471853007336 PQQ-like domain; Region: PQQ_2; pfam13360 471853007337 hypothetical protein; Provisional; Region: PRK01346 471853007338 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853007339 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853007340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853007341 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 471853007342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007343 putative PBP binding loops; other site 471853007344 dimer interface [polypeptide binding]; other site 471853007345 ABC-ATPase subunit interface; other site 471853007346 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853007347 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007348 dimer interface [polypeptide binding]; other site 471853007349 conserved gate region; other site 471853007350 putative PBP binding loops; other site 471853007351 ABC-ATPase subunit interface; other site 471853007352 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 471853007353 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471853007354 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 471853007355 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 471853007356 Zn binding site [ion binding]; other site 471853007357 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471853007358 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853007359 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 471853007360 HPr interaction site; other site 471853007361 glycerol kinase (GK) interaction site [polypeptide binding]; other site 471853007362 active site 471853007363 phosphorylation site [posttranslational modification] 471853007364 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 471853007365 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 471853007366 Mechanosensitive ion channel; Region: MS_channel; pfam00924 471853007367 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 471853007368 active site turn [active] 471853007369 phosphorylation site [posttranslational modification] 471853007370 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 471853007371 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 471853007372 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 471853007373 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 471853007374 apolar tunnel; other site 471853007375 heme binding site [chemical binding]; other site 471853007376 dimerization interface [polypeptide binding]; other site 471853007377 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 471853007378 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 471853007379 active site 471853007380 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 471853007381 catalytic triad [active] 471853007382 dimer interface [polypeptide binding]; other site 471853007383 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 471853007384 active site 471853007385 YfjP GTPase; Region: YfjP; cd11383 471853007386 G1 box; other site 471853007387 GTP/Mg2+ binding site [chemical binding]; other site 471853007388 Switch I region; other site 471853007389 G2 box; other site 471853007390 Switch II region; other site 471853007391 G3 box; other site 471853007392 G4 box; other site 471853007393 G5 box; other site 471853007394 Dynamin family; Region: Dynamin_N; pfam00350 471853007395 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 471853007396 G1 box; other site 471853007397 GTP/Mg2+ binding site [chemical binding]; other site 471853007398 G2 box; other site 471853007399 Switch I region; other site 471853007400 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 471853007401 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 471853007402 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 471853007403 ABC transporter; Region: ABC_tran_2; pfam12848 471853007404 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 471853007405 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 471853007406 dimer interface [polypeptide binding]; other site 471853007407 ssDNA binding site [nucleotide binding]; other site 471853007408 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471853007409 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853007410 G1 box; other site 471853007411 GTP/Mg2+ binding site [chemical binding]; other site 471853007412 G2 box; other site 471853007413 Switch I region; other site 471853007414 G3 box; other site 471853007415 Switch II region; other site 471853007416 G4 box; other site 471853007417 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 471853007418 G1 box; other site 471853007419 GTP/Mg2+ binding site [chemical binding]; other site 471853007420 G2 box; other site 471853007421 Switch I region; other site 471853007422 G3 box; other site 471853007423 Switch II region; other site 471853007424 G4 box; other site 471853007425 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853007426 S-adenosylmethionine binding site [chemical binding]; other site 471853007427 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 471853007428 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471853007429 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 471853007430 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471853007431 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 471853007432 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 471853007433 Fe-S metabolism associated domain; Region: SufE; cl00951 471853007434 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 471853007435 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 471853007436 active site residue [active] 471853007437 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 471853007438 active site residue [active] 471853007439 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 471853007440 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 471853007441 active site 471853007442 catalytic site [active] 471853007443 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 471853007444 putative active site [active] 471853007445 putative substrate binding site [chemical binding]; other site 471853007446 catalytic site [active] 471853007447 dimer interface [polypeptide binding]; other site 471853007448 Predicted lipoprotein of unknown function (DUF2380); Region: DUF2380; cl15289 471853007449 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471853007450 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853007451 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853007452 putative DNA binding site [nucleotide binding]; other site 471853007453 putative Zn2+ binding site [ion binding]; other site 471853007454 Low molecular weight phosphatase family; Region: LMWPc; cl00105 471853007455 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 471853007456 active site 471853007457 Low molecular weight phosphatase family; Region: LMWPc; cd00115 471853007458 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 471853007459 active site 471853007460 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 471853007461 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853007462 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853007463 dimerization interface [polypeptide binding]; other site 471853007464 putative DNA binding site [nucleotide binding]; other site 471853007465 putative Zn2+ binding site [ion binding]; other site 471853007466 Fatty acid desaturase; Region: FA_desaturase; pfam00487 471853007467 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 471853007468 putative di-iron ligands [ion binding]; other site 471853007469 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 471853007470 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 471853007471 Walker A/P-loop; other site 471853007472 ATP binding site [chemical binding]; other site 471853007473 Q-loop/lid; other site 471853007474 ABC transporter signature motif; other site 471853007475 Walker B; other site 471853007476 D-loop; other site 471853007477 H-loop/switch region; other site 471853007478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853007479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853007480 NMT1-like family; Region: NMT1_2; cl15260 471853007481 NMT1-like family; Region: NMT1_2; cl15260 471853007482 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 471853007483 catalytic triad [active] 471853007484 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 471853007485 homotrimer interaction site [polypeptide binding]; other site 471853007486 putative active site [active] 471853007487 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 471853007488 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 471853007489 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 471853007490 putative active site [active] 471853007491 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 471853007492 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853007493 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 471853007494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853007495 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 471853007496 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 471853007497 Walker A/P-loop; other site 471853007498 ATP binding site [chemical binding]; other site 471853007499 Q-loop/lid; other site 471853007500 ABC transporter signature motif; other site 471853007501 Walker B; other site 471853007502 D-loop; other site 471853007503 H-loop/switch region; other site 471853007504 NMT1-like family; Region: NMT1_2; cl15260 471853007505 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 471853007506 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 471853007507 CCC1-related family of proteins; Region: CCC1_like; cl00278 471853007508 Protein of unknown function DUF72; Region: DUF72; cl00777 471853007509 NmrA-like family; Region: NmrA; pfam05368 471853007510 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853007511 NAD(P) binding site [chemical binding]; other site 471853007512 active site 471853007513 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 471853007514 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853007515 NAD(P) binding site [chemical binding]; other site 471853007516 endonuclease IV; Provisional; Region: PRK01060 471853007517 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 471853007518 AP (apurinic/apyrimidinic) site pocket; other site 471853007519 DNA interaction; other site 471853007520 Metal-binding active site; metal-binding site 471853007521 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853007522 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 471853007523 Helix-turn-helix domains; Region: HTH; cl00088 471853007524 FAD binding domain; Region: FAD_binding_4; pfam01565 471853007525 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853007526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853007527 active site 471853007528 phosphorylation site [posttranslational modification] 471853007529 intermolecular recognition site; other site 471853007530 dimerization interface [polypeptide binding]; other site 471853007531 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853007532 dimerization interface [polypeptide binding]; other site 471853007533 DNA binding residues [nucleotide binding] 471853007534 Histidine kinase; Region: HisKA_3; pfam07730 471853007535 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471853007536 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 471853007537 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 471853007538 Walker A/P-loop; other site 471853007539 ATP binding site [chemical binding]; other site 471853007540 Q-loop/lid; other site 471853007541 ABC transporter signature motif; other site 471853007542 Walker B; other site 471853007543 D-loop; other site 471853007544 H-loop/switch region; other site 471853007545 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 471853007546 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853007547 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 471853007548 OPT oligopeptide transporter protein; Region: OPT; cl14607 471853007549 Family description; Region: UvrD_C_2; cl15862 471853007550 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853007551 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 471853007552 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471853007553 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853007554 Predicted ATPase [General function prediction only]; Region: COG3899 471853007555 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853007556 DNA binding residues [nucleotide binding] 471853007557 dimerization interface [polypeptide binding]; other site 471853007558 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 471853007559 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 471853007560 metal binding site [ion binding]; metal-binding site 471853007561 substrate binding pocket [chemical binding]; other site 471853007562 aldose dehydrogenase; Validated; Region: PRK06398 471853007563 classical (c) SDRs; Region: SDR_c; cd05233 471853007564 NAD(P) binding site [chemical binding]; other site 471853007565 active site 471853007566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007567 dimer interface [polypeptide binding]; other site 471853007568 conserved gate region; other site 471853007569 putative PBP binding loops; other site 471853007570 ABC-ATPase subunit interface; other site 471853007571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007572 dimer interface [polypeptide binding]; other site 471853007573 conserved gate region; other site 471853007574 putative PBP binding loops; other site 471853007575 ABC-ATPase subunit interface; other site 471853007576 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853007577 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853007578 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 471853007579 Transcriptional regulators [Transcription]; Region: FadR; COG2186 471853007580 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853007581 DNA-binding site [nucleotide binding]; DNA binding site 471853007582 FCD domain; Region: FCD; cl11656 471853007583 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 471853007584 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853007585 S-adenosylmethionine binding site [chemical binding]; other site 471853007586 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 471853007587 Histidine kinase; Region: HisKA_3; pfam07730 471853007588 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471853007589 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853007590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853007591 active site 471853007592 phosphorylation site [posttranslational modification] 471853007593 intermolecular recognition site; other site 471853007594 dimerization interface [polypeptide binding]; other site 471853007595 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853007596 DNA binding residues [nucleotide binding] 471853007597 dimerization interface [polypeptide binding]; other site 471853007598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853007599 putative substrate translocation pore; other site 471853007600 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 471853007601 amino acid transporter; Region: 2A0306; TIGR00909 471853007602 Spore germination protein; Region: Spore_permease; cl15802 471853007603 Spore germination protein; Region: Spore_permease; cl15802 471853007604 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 471853007605 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 471853007606 Fibronectin type III-like domain; Region: Fn3-like; cl15273 471853007607 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853007608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007609 dimer interface [polypeptide binding]; other site 471853007610 conserved gate region; other site 471853007611 putative PBP binding loops; other site 471853007612 ABC-ATPase subunit interface; other site 471853007613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007614 dimer interface [polypeptide binding]; other site 471853007615 conserved gate region; other site 471853007616 putative PBP binding loops; other site 471853007617 ABC-ATPase subunit interface; other site 471853007618 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853007619 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853007620 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853007621 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853007622 DNA binding site [nucleotide binding] 471853007623 domain linker motif; other site 471853007624 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 471853007625 Phosphotransferase enzyme family; Region: APH; pfam01636 471853007626 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471853007627 active site 471853007628 ATP binding site [chemical binding]; other site 471853007629 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 471853007630 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853007631 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853007632 DNA binding site [nucleotide binding] 471853007633 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853007634 ligand binding site [chemical binding]; other site 471853007635 dimerization interface [polypeptide binding]; other site 471853007636 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 471853007637 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471853007638 Walker A/P-loop; other site 471853007639 ATP binding site [chemical binding]; other site 471853007640 Q-loop/lid; other site 471853007641 ABC transporter signature motif; other site 471853007642 Walker B; other site 471853007643 D-loop; other site 471853007644 H-loop/switch region; other site 471853007645 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853007646 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 471853007647 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471853007648 Walker A/P-loop; other site 471853007649 ATP binding site [chemical binding]; other site 471853007650 Q-loop/lid; other site 471853007651 ABC transporter signature motif; other site 471853007652 Walker B; other site 471853007653 D-loop; other site 471853007654 H-loop/switch region; other site 471853007655 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853007656 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 471853007657 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007658 dimer interface [polypeptide binding]; other site 471853007659 conserved gate region; other site 471853007660 putative PBP binding loops; other site 471853007661 ABC-ATPase subunit interface; other site 471853007662 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471853007663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007664 dimer interface [polypeptide binding]; other site 471853007665 conserved gate region; other site 471853007666 putative PBP binding loops; other site 471853007667 ABC-ATPase subunit interface; other site 471853007668 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 471853007669 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 471853007670 substrate binding site [chemical binding]; other site 471853007671 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 471853007672 nudix motif; other site 471853007673 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 471853007674 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471853007675 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471853007676 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853007677 Walker A/P-loop; other site 471853007678 ATP binding site [chemical binding]; other site 471853007679 Q-loop/lid; other site 471853007680 ABC transporter signature motif; other site 471853007681 Walker B; other site 471853007682 D-loop; other site 471853007683 H-loop/switch region; other site 471853007684 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853007685 Walker A/P-loop; other site 471853007686 ATP binding site [chemical binding]; other site 471853007687 Q-loop/lid; other site 471853007688 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 471853007689 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 471853007690 active site 471853007691 dimerization interface [polypeptide binding]; other site 471853007692 Ribonuclease PH; Region: RNase_PH_bact; cd11362 471853007693 hexamer interface [polypeptide binding]; other site 471853007694 active site 471853007695 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 471853007696 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 471853007697 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471853007698 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 471853007699 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 471853007700 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 471853007701 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 471853007702 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 471853007703 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 471853007704 active site 471853007705 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 471853007706 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471853007707 ATP binding site [chemical binding]; other site 471853007708 putative Mg++ binding site [ion binding]; other site 471853007709 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 471853007710 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471853007711 substrate binding pocket [chemical binding]; other site 471853007712 catalytic triad [active] 471853007713 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 471853007714 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 471853007715 active site 471853007716 catalytic site [active] 471853007717 metal binding site [ion binding]; metal-binding site 471853007718 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 471853007719 active site 471853007720 trimer interface [polypeptide binding]; other site 471853007721 allosteric site; other site 471853007722 active site lid [active] 471853007723 hexamer (dimer of trimers) interface [polypeptide binding]; other site 471853007724 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 471853007725 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 471853007726 Walker A/P-loop; other site 471853007727 ATP binding site [chemical binding]; other site 471853007728 Q-loop/lid; other site 471853007729 ABC transporter signature motif; other site 471853007730 Walker B; other site 471853007731 D-loop; other site 471853007732 H-loop/switch region; other site 471853007733 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 471853007734 IHF dimer interface [polypeptide binding]; other site 471853007735 IHF - DNA interface [nucleotide binding]; other site 471853007736 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471853007737 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471853007738 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853007739 ATP binding site [chemical binding]; other site 471853007740 putative Mg++ binding site [ion binding]; other site 471853007741 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471853007742 nucleotide binding region [chemical binding]; other site 471853007743 ATP-binding site [chemical binding]; other site 471853007744 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 471853007745 AAA domain; Region: AAA_33; pfam13671 471853007746 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853007747 active site 471853007748 hypothetical protein; Provisional; Region: PRK01346 471853007749 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853007750 Coenzyme A binding pocket [chemical binding]; other site 471853007751 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 471853007752 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471853007753 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471853007754 Sulfatase; Region: Sulfatase; cl10460 471853007755 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 471853007756 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 471853007757 SmpB-tmRNA interface; other site 471853007758 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 471853007759 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 471853007760 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 471853007761 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 471853007762 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853007763 Walker A/P-loop; other site 471853007764 ATP binding site [chemical binding]; other site 471853007765 Q-loop/lid; other site 471853007766 ABC transporter signature motif; other site 471853007767 Walker B; other site 471853007768 D-loop; other site 471853007769 H-loop/switch region; other site 471853007770 pyruvate phosphate dikinase; Provisional; Region: PRK09279 471853007771 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 471853007772 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 471853007773 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 471853007774 peptide chain release factor 2; Validated; Region: prfB; PRK00578 471853007775 RF-1 domain; Region: RF-1; cl02875 471853007776 RF-1 domain; Region: RF-1; cl02875 471853007777 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471853007778 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471853007779 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471853007780 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 471853007781 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471853007782 catalytic residue [active] 471853007783 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 471853007784 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 471853007785 dimerization interface [polypeptide binding]; other site 471853007786 active site 471853007787 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853007788 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 471853007789 Quinolinate synthetase A protein; Region: NadA; cl00420 471853007790 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 471853007791 nudix motif; other site 471853007792 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 471853007793 Helix-turn-helix domains; Region: HTH; cl00088 471853007794 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 471853007795 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853007796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853007797 putative substrate translocation pore; other site 471853007798 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 471853007799 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 471853007800 Filamin/ABP280 repeat; Region: Filamin; cl02665 471853007801 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 471853007802 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 471853007803 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 471853007804 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 471853007805 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853007806 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 471853007807 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 471853007808 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 471853007809 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 471853007810 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 471853007811 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 471853007812 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 471853007813 Walker A motif; other site 471853007814 hexamer interface [polypeptide binding]; other site 471853007815 ATP binding site [chemical binding]; other site 471853007816 Walker B motif; other site 471853007817 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 471853007818 putative dimer interface [polypeptide binding]; other site 471853007819 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853007820 Helix-turn-helix domain; Region: HTH_18; pfam12833 471853007821 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 471853007822 DinB superfamily; Region: DinB_2; pfam12867 471853007823 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 471853007824 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 471853007825 putative active site [active] 471853007826 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 471853007827 active site 471853007828 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 471853007829 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 471853007830 active site 471853007831 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471853007832 DNA binding site [nucleotide binding] 471853007833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853007834 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 471853007835 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 471853007836 nitrite reductase subunit NirD; Provisional; Region: PRK14989 471853007837 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 471853007838 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 471853007839 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 471853007840 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 471853007841 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 471853007842 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 471853007843 [4Fe-4S] binding site [ion binding]; other site 471853007844 molybdopterin cofactor binding site; other site 471853007845 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 471853007846 molybdopterin cofactor binding site; other site 471853007847 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 471853007848 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 471853007849 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 471853007850 [4Fe-4S] binding site [ion binding]; other site 471853007851 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471853007852 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471853007853 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471853007854 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 471853007855 molybdopterin cofactor binding site; other site 471853007856 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 471853007857 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 471853007858 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 471853007859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853007860 putative substrate translocation pore; other site 471853007861 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 471853007862 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 471853007863 GTP binding site; other site 471853007864 aminotransferase; Validated; Region: PRK07777 471853007865 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471853007866 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853007867 homodimer interface [polypeptide binding]; other site 471853007868 catalytic residue [active] 471853007869 Protein of unknown function (DUF419); Region: DUF419; cl15265 471853007870 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471853007871 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471853007872 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 471853007873 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 471853007874 catalytic site [active] 471853007875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007876 dimer interface [polypeptide binding]; other site 471853007877 conserved gate region; other site 471853007878 putative PBP binding loops; other site 471853007879 ABC-ATPase subunit interface; other site 471853007880 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853007881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007882 dimer interface [polypeptide binding]; other site 471853007883 conserved gate region; other site 471853007884 putative PBP binding loops; other site 471853007885 ABC-ATPase subunit interface; other site 471853007886 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853007887 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853007888 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 471853007889 Histidine kinase; Region: HisKA_3; pfam07730 471853007890 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471853007891 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853007892 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853007893 active site 471853007894 phosphorylation site [posttranslational modification] 471853007895 intermolecular recognition site; other site 471853007896 dimerization interface [polypeptide binding]; other site 471853007897 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853007898 DNA binding residues [nucleotide binding] 471853007899 dimerization interface [polypeptide binding]; other site 471853007900 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471853007901 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 471853007902 Walker A/P-loop; other site 471853007903 ATP binding site [chemical binding]; other site 471853007904 Q-loop/lid; other site 471853007905 ABC transporter signature motif; other site 471853007906 Walker B; other site 471853007907 D-loop; other site 471853007908 H-loop/switch region; other site 471853007909 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471853007910 FtsX-like permease family; Region: FtsX; cl15850 471853007911 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 471853007912 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853007913 Transcription factor WhiB; Region: Whib; pfam02467 471853007914 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 471853007915 PAS fold; Region: PAS_4; pfam08448 471853007916 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 471853007917 Histidine kinase; Region: HisKA_2; cl06527 471853007918 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 471853007919 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 471853007920 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 471853007921 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007922 dimer interface [polypeptide binding]; other site 471853007923 conserved gate region; other site 471853007924 putative PBP binding loops; other site 471853007925 ABC-ATPase subunit interface; other site 471853007926 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 471853007927 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007928 dimer interface [polypeptide binding]; other site 471853007929 conserved gate region; other site 471853007930 putative PBP binding loops; other site 471853007931 ABC-ATPase subunit interface; other site 471853007932 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853007933 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471853007934 Helix-turn-helix domains; Region: HTH; cl00088 471853007935 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 471853007936 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853007937 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853007938 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853007939 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007940 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 471853007941 ABC-ATPase subunit interface; other site 471853007942 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853007943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007944 dimer interface [polypeptide binding]; other site 471853007945 conserved gate region; other site 471853007946 putative PBP binding loops; other site 471853007947 ABC-ATPase subunit interface; other site 471853007948 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 471853007949 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853007950 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853007951 DNA binding site [nucleotide binding] 471853007952 domain linker motif; other site 471853007953 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 471853007954 putative dimerization interface [polypeptide binding]; other site 471853007955 putative ligand binding site [chemical binding]; other site 471853007956 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 471853007957 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 471853007958 active site 471853007959 catalytic site [active] 471853007960 Lamin Tail Domain; Region: LTD; pfam00932 471853007961 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471853007962 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853007963 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853007964 DNA binding site [nucleotide binding] 471853007965 domain linker motif; other site 471853007966 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853007967 dimerization interface [polypeptide binding]; other site 471853007968 ligand binding site [chemical binding]; other site 471853007969 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 471853007970 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853007971 Walker A/P-loop; other site 471853007972 ATP binding site [chemical binding]; other site 471853007973 Q-loop/lid; other site 471853007974 ABC transporter signature motif; other site 471853007975 Walker B; other site 471853007976 D-loop; other site 471853007977 H-loop/switch region; other site 471853007978 TOBE domain; Region: TOBE_2; cl01440 471853007979 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853007980 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853007981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007982 dimer interface [polypeptide binding]; other site 471853007983 conserved gate region; other site 471853007984 putative PBP binding loops; other site 471853007985 ABC-ATPase subunit interface; other site 471853007986 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007987 dimer interface [polypeptide binding]; other site 471853007988 conserved gate region; other site 471853007989 putative PBP binding loops; other site 471853007990 ABC-ATPase subunit interface; other site 471853007991 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 471853007992 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853007993 active site 471853007994 motif I; other site 471853007995 motif II; other site 471853007996 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 471853007997 Proline dehydrogenase; Region: Pro_dh; cl03282 471853007998 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 471853007999 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471853008000 NAD(P) binding site [chemical binding]; other site 471853008001 catalytic residues [active] 471853008002 PAS fold; Region: PAS_4; pfam08448 471853008003 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471853008004 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853008005 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 471853008006 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853008007 Coenzyme A binding pocket [chemical binding]; other site 471853008008 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853008009 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 471853008010 Helix-turn-helix domains; Region: HTH; cl00088 471853008011 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 471853008012 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853008013 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471853008014 NAD(P) binding site [chemical binding]; other site 471853008015 active site 471853008016 OsmC-like protein; Region: OsmC; cl00767 471853008017 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853008018 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471853008019 active site 471853008020 catalytic tetrad [active] 471853008021 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853008022 dimerization interface [polypeptide binding]; other site 471853008023 putative DNA binding site [nucleotide binding]; other site 471853008024 putative Zn2+ binding site [ion binding]; other site 471853008025 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 471853008026 putative hydrophobic ligand binding site [chemical binding]; other site 471853008027 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 471853008028 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853008029 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471853008030 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 471853008031 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471853008032 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 471853008033 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471853008034 Glycerate kinase family; Region: Gly_kinase; cl00841 471853008035 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 471853008036 dimerization interface [polypeptide binding]; other site 471853008037 active site 471853008038 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 471853008039 folate binding site [chemical binding]; other site 471853008040 NADP+ binding site [chemical binding]; other site 471853008041 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 471853008042 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853008043 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853008044 DNA binding site [nucleotide binding] 471853008045 domain linker motif; other site 471853008046 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853008047 ligand binding site [chemical binding]; other site 471853008048 dimerization interface [polypeptide binding]; other site 471853008049 MoxR-like ATPases [General function prediction only]; Region: COG0714 471853008050 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853008051 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 471853008052 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471853008053 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 471853008054 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 471853008055 putative DNA binding site [nucleotide binding]; other site 471853008056 catalytic residue [active] 471853008057 putative H2TH interface [polypeptide binding]; other site 471853008058 putative catalytic residues [active] 471853008059 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 471853008060 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 471853008061 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853008062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853008063 dimer interface [polypeptide binding]; other site 471853008064 conserved gate region; other site 471853008065 putative PBP binding loops; other site 471853008066 ABC-ATPase subunit interface; other site 471853008067 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 471853008068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853008069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853008070 putative PBP binding loops; other site 471853008071 dimer interface [polypeptide binding]; other site 471853008072 ABC-ATPase subunit interface; other site 471853008073 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853008074 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853008075 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853008076 DNA binding site [nucleotide binding] 471853008077 domain linker motif; other site 471853008078 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853008079 dimerization interface [polypeptide binding]; other site 471853008080 ligand binding site [chemical binding]; other site 471853008081 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 471853008082 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 471853008083 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 471853008084 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471853008085 FAD binding domain; Region: FAD_binding_4; pfam01565 471853008086 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 471853008087 A new structural DNA glycosylase; Region: AlkD_like; cd06561 471853008088 active site 471853008089 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853008090 dimerization interface [polypeptide binding]; other site 471853008091 putative DNA binding site [nucleotide binding]; other site 471853008092 putative Zn2+ binding site [ion binding]; other site 471853008093 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 471853008094 putative hydrophobic ligand binding site [chemical binding]; other site 471853008095 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 471853008096 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 471853008097 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 471853008098 DinB superfamily; Region: DinB_2; pfam12867 471853008099 Helix-turn-helix domains; Region: HTH; cl00088 471853008100 WYL domain; Region: WYL; cl14852 471853008101 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 471853008102 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 471853008103 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 471853008104 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 471853008105 Protein of unknown function DUF45; Region: DUF45; cl00636 471853008106 MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816 471853008107 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471853008108 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 471853008109 Walker A/P-loop; other site 471853008110 ATP binding site [chemical binding]; other site 471853008111 Q-loop/lid; other site 471853008112 ABC transporter signature motif; other site 471853008113 Walker B; other site 471853008114 D-loop; other site 471853008115 H-loop/switch region; other site 471853008116 PhoD-like phosphatase; Region: PhoD; pfam09423 471853008117 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 471853008118 putative active site [active] 471853008119 putative metal binding site [ion binding]; other site 471853008120 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 471853008121 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853008122 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 471853008123 Family description; Region: UvrD_C_2; cl15862 471853008124 HRDC domain; Region: HRDC; cl02578 471853008125 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 471853008126 catalytic residues [active] 471853008127 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 471853008128 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 471853008129 putative NADH binding site [chemical binding]; other site 471853008130 putative active site [active] 471853008131 nudix motif; other site 471853008132 putative metal binding site [ion binding]; other site 471853008133 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471853008134 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 471853008135 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853008136 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 471853008137 Family description; Region: UvrD_C_2; cl15862 471853008138 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 471853008139 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 471853008140 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 471853008141 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 471853008142 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 471853008143 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 471853008144 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 471853008145 dinuclear metal binding motif [ion binding]; other site 471853008146 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 471853008147 DEAD-like helicases superfamily; Region: DEXDc; smart00487 471853008148 ATP binding site [chemical binding]; other site 471853008149 Mg++ binding site [ion binding]; other site 471853008150 motif III; other site 471853008151 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471853008152 nucleotide binding region [chemical binding]; other site 471853008153 ATP-binding site [chemical binding]; other site 471853008154 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 471853008155 MarC family integral membrane protein; Region: MarC; cl00919 471853008156 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 471853008157 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 471853008158 proline aminopeptidase P II; Provisional; Region: PRK10879 471853008159 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 471853008160 active site 471853008161 Predicted membrane protein [Function unknown]; Region: COG3463 471853008162 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 471853008163 MgtE intracellular N domain; Region: MgtE_N; cl15244 471853008164 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 471853008165 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 471853008166 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 471853008167 Domain of unknown function DUF59; Region: DUF59; cl00941 471853008168 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 471853008169 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 471853008170 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471853008171 active site 471853008172 metal binding site [ion binding]; metal-binding site 471853008173 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 471853008174 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 471853008175 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 471853008176 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 471853008177 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 471853008178 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853008179 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471853008180 DNA binding residues [nucleotide binding] 471853008181 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853008182 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471853008183 multifunctional aminopeptidase A; Provisional; Region: PRK00913 471853008184 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 471853008185 interface (dimer of trimers) [polypeptide binding]; other site 471853008186 Substrate-binding/catalytic site; other site 471853008187 Zn-binding sites [ion binding]; other site 471853008188 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 471853008189 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 471853008190 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 471853008191 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 471853008192 metal binding site [ion binding]; metal-binding site 471853008193 putative dimer interface [polypeptide binding]; other site 471853008194 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471853008195 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853008196 Walker A/P-loop; other site 471853008197 ATP binding site [chemical binding]; other site 471853008198 Q-loop/lid; other site 471853008199 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853008200 ABC transporter signature motif; other site 471853008201 Walker B; other site 471853008202 D-loop; other site 471853008203 H-loop/switch region; other site 471853008204 ABC transporter; Region: ABC_tran_2; pfam12848 471853008205 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853008206 Walker A/P-loop; other site 471853008207 ATP binding site [chemical binding]; other site 471853008208 Q-loop/lid; other site 471853008209 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 471853008210 ABC transporter signature motif; other site 471853008211 Walker B; other site 471853008212 D-loop; other site 471853008213 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471853008214 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 471853008215 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471853008216 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471853008217 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 471853008218 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 471853008219 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 471853008220 active site 471853008221 substrate binding site [chemical binding]; other site 471853008222 metal binding site [ion binding]; metal-binding site 471853008223 Helix-turn-helix domains; Region: HTH; cl00088 471853008224 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 471853008225 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471853008226 active site 471853008227 Domain of unknown function (DUF202); Region: DUF202; cl09954 471853008228 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 471853008229 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 471853008230 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 471853008231 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 471853008232 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 471853008233 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 471853008234 active site 471853008235 TDP-binding site; other site 471853008236 acceptor substrate-binding pocket; other site 471853008237 homodimer interface [polypeptide binding]; other site 471853008238 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 471853008239 active site 471853008240 catalytic motif [active] 471853008241 Zn binding site [ion binding]; other site 471853008242 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 471853008243 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 471853008244 TM-ABC transporter signature motif; other site 471853008245 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 471853008246 TM-ABC transporter signature motif; other site 471853008247 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 471853008248 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 471853008249 Walker A/P-loop; other site 471853008250 ATP binding site [chemical binding]; other site 471853008251 Q-loop/lid; other site 471853008252 ABC transporter signature motif; other site 471853008253 Walker B; other site 471853008254 D-loop; other site 471853008255 H-loop/switch region; other site 471853008256 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 471853008257 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 471853008258 ligand binding site [chemical binding]; other site 471853008259 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 471853008260 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 471853008261 metal binding site [ion binding]; metal-binding site 471853008262 putative dimer interface [polypeptide binding]; other site 471853008263 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471853008264 active site 471853008265 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 471853008266 putative Iron-sulfur protein interface [polypeptide binding]; other site 471853008267 putative proximal heme binding site [chemical binding]; other site 471853008268 putative SdhD-like interface [polypeptide binding]; other site 471853008269 putative distal heme binding site [chemical binding]; other site 471853008270 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 471853008271 putative Iron-sulfur protein interface [polypeptide binding]; other site 471853008272 putative proximal heme binding site [chemical binding]; other site 471853008273 putative SdhC-like subunit interface [polypeptide binding]; other site 471853008274 putative distal heme binding site [chemical binding]; other site 471853008275 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 471853008276 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853008277 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 471853008278 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 471853008279 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 471853008280 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 471853008281 active site 471853008282 ATP binding site [chemical binding]; other site 471853008283 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 471853008284 hypothetical protein; Provisional; Region: PRK13679 471853008285 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 471853008286 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 471853008287 active site 471853008288 HIGH motif; other site 471853008289 dimer interface [polypeptide binding]; other site 471853008290 KMSKS motif; other site 471853008291 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 471853008292 Helix-turn-helix domains; Region: HTH; cl00088 471853008293 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 471853008294 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 471853008295 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 471853008296 dimer interface [polypeptide binding]; other site 471853008297 active site 471853008298 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 471853008299 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 471853008300 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 471853008301 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 471853008302 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 471853008303 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471853008304 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 471853008305 Walker A/P-loop; other site 471853008306 ATP binding site [chemical binding]; other site 471853008307 Q-loop/lid; other site 471853008308 ABC transporter signature motif; other site 471853008309 Walker B; other site 471853008310 D-loop; other site 471853008311 H-loop/switch region; other site 471853008312 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471853008313 FtsX-like permease family; Region: FtsX; cl15850 471853008314 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 471853008315 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853008316 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471853008317 DNA binding residues [nucleotide binding] 471853008318 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853008319 putative DNA binding site [nucleotide binding]; other site 471853008320 putative Zn2+ binding site [ion binding]; other site 471853008321 Dynein light intermediate chain (DLIC); Region: DLIC; pfam05783 471853008322 H+ Antiporter protein; Region: 2A0121; TIGR00900 471853008323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853008324 TIGR03086 family protein; Region: TIGR03086 471853008325 Helix-turn-helix domain; Region: HTH_18; pfam12833 471853008326 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853008327 Cupin domain; Region: Cupin_2; cl09118 471853008328 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 471853008329 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471853008330 classical (c) SDRs; Region: SDR_c; cd05233 471853008331 NAD(P) binding site [chemical binding]; other site 471853008332 active site 471853008333 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 471853008334 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 471853008335 inhibitor site; inhibition site 471853008336 active site 471853008337 dimer interface [polypeptide binding]; other site 471853008338 catalytic residue [active] 471853008339 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 471853008340 active site 471853008341 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853008342 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853008343 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 471853008344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853008345 dimer interface [polypeptide binding]; other site 471853008346 conserved gate region; other site 471853008347 putative PBP binding loops; other site 471853008348 ABC-ATPase subunit interface; other site 471853008349 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853008350 dimer interface [polypeptide binding]; other site 471853008351 conserved gate region; other site 471853008352 putative PBP binding loops; other site 471853008353 ABC-ATPase subunit interface; other site 471853008354 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 471853008355 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471853008356 active site 471853008357 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471853008358 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471853008359 Helix-turn-helix domains; Region: HTH; cl00088 471853008360 Bacterial transcriptional regulator; Region: IclR; pfam01614 471853008361 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 471853008362 homotrimer interaction site [polypeptide binding]; other site 471853008363 putative active site [active] 471853008364 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 471853008365 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 471853008366 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471853008367 catalytic residue [active] 471853008368 classical (c) SDRs; Region: SDR_c; cd05233 471853008369 NAD(P) binding site [chemical binding]; other site 471853008370 active site 471853008371 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 471853008372 putative active site [active] 471853008373 putative DNA binding site [nucleotide binding]; other site 471853008374 putative phosphate binding site [ion binding]; other site 471853008375 putative catalytic site [active] 471853008376 metal binding site A [ion binding]; metal-binding site 471853008377 putative AP binding site [nucleotide binding]; other site 471853008378 putative metal binding site B [ion binding]; other site 471853008379 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 471853008380 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 471853008381 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 471853008382 homodimer interface [polypeptide binding]; other site 471853008383 NADP binding site [chemical binding]; other site 471853008384 substrate binding site [chemical binding]; other site 471853008385 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 471853008386 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 471853008387 dimer interface [polypeptide binding]; other site 471853008388 glycine-pyridoxal phosphate binding site [chemical binding]; other site 471853008389 active site 471853008390 folate binding site [chemical binding]; other site 471853008391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 471853008392 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 471853008393 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 471853008394 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853008395 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 471853008396 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 471853008397 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 471853008398 putative substrate binding site [chemical binding]; other site 471853008399 putative active site [active] 471853008400 putative cosubstrate binding site; other site 471853008401 catalytic site [active] 471853008402 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 471853008403 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 471853008404 Walker A/P-loop; other site 471853008405 ATP binding site [chemical binding]; other site 471853008406 Q-loop/lid; other site 471853008407 ABC transporter signature motif; other site 471853008408 Walker B; other site 471853008409 D-loop; other site 471853008410 H-loop/switch region; other site 471853008411 Helix-turn-helix domains; Region: HTH; cl00088 471853008412 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471853008413 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471853008414 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 471853008415 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 471853008416 TM-ABC transporter signature motif; other site 471853008417 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 471853008418 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 471853008419 Walker A/P-loop; other site 471853008420 ATP binding site [chemical binding]; other site 471853008421 Q-loop/lid; other site 471853008422 ABC transporter signature motif; other site 471853008423 Walker B; other site 471853008424 D-loop; other site 471853008425 H-loop/switch region; other site 471853008426 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 471853008427 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 471853008428 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 471853008429 putative ligand binding site [chemical binding]; other site 471853008430 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 471853008431 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 471853008432 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 471853008433 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 471853008434 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853008435 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853008436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853008437 dimer interface [polypeptide binding]; other site 471853008438 conserved gate region; other site 471853008439 putative PBP binding loops; other site 471853008440 ABC-ATPase subunit interface; other site 471853008441 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853008442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853008443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853008444 dimer interface [polypeptide binding]; other site 471853008445 conserved gate region; other site 471853008446 putative PBP binding loops; other site 471853008447 ABC-ATPase subunit interface; other site 471853008448 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 471853008449 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; cl15460 471853008450 Helix-turn-helix domains; Region: HTH; cl00088 471853008451 hypothetical protein; Provisional; Region: PRK07588 471853008452 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853008453 malate dehydrogenase; Provisional; Region: PRK05442 471853008454 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 471853008455 NAD(P) binding site [chemical binding]; other site 471853008456 dimer interface [polypeptide binding]; other site 471853008457 malate binding site [chemical binding]; other site 471853008458 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 471853008459 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 471853008460 amphipathic channel; other site 471853008461 Asn-Pro-Ala signature motifs; other site 471853008462 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 471853008463 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 471853008464 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 471853008465 purine monophosphate binding site [chemical binding]; other site 471853008466 dimer interface [polypeptide binding]; other site 471853008467 putative catalytic residues [active] 471853008468 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 471853008469 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 471853008470 active site 471853008471 cosubstrate binding site; other site 471853008472 substrate binding site [chemical binding]; other site 471853008473 catalytic site [active] 471853008474 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 471853008475 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853008476 CoA-ligase; Region: Ligase_CoA; cl02894 471853008477 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 471853008478 ATP-grasp domain; Region: ATP-grasp_4; cl03087 471853008479 CoA-ligase; Region: Ligase_CoA; cl02894 471853008480 Clp amino terminal domain; Region: Clp_N; pfam02861 471853008481 OpgC protein; Region: OpgC_C; cl00792 471853008482 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 471853008483 active site 471853008484 catalytic triad [active] 471853008485 oxyanion hole [active] 471853008486 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853008487 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 471853008488 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 471853008489 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853008490 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 471853008491 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 471853008492 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853008493 Family description; Region: UvrD_C_2; cl15862 471853008494 Histidine kinase; Region: HisKA_3; pfam07730 471853008495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471853008496 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853008497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853008498 active site 471853008499 phosphorylation site [posttranslational modification] 471853008500 intermolecular recognition site; other site 471853008501 dimerization interface [polypeptide binding]; other site 471853008502 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853008503 DNA binding residues [nucleotide binding] 471853008504 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 471853008505 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853008506 Walker A/P-loop; other site 471853008507 ATP binding site [chemical binding]; other site 471853008508 Q-loop/lid; other site 471853008509 ABC transporter signature motif; other site 471853008510 Walker B; other site 471853008511 D-loop; other site 471853008512 H-loop/switch region; other site 471853008513 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 471853008514 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 471853008515 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 471853008516 trimer interface [polypeptide binding]; other site 471853008517 active site 471853008518 dimer interface [polypeptide binding]; other site 471853008519 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853008520 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853008521 DNA binding residues [nucleotide binding] 471853008522 dimerization interface [polypeptide binding]; other site 471853008523 PspC domain; Region: PspC; cl00864 471853008524 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471853008525 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471853008526 PspC domain; Region: PspC; cl00864 471853008527 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 471853008528 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 471853008529 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471853008530 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471853008531 GMP synthase; Reviewed; Region: guaA; PRK00074 471853008532 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 471853008533 AMP/PPi binding site [chemical binding]; other site 471853008534 candidate oxyanion hole; other site 471853008535 catalytic triad [active] 471853008536 potential glutamine specificity residues [chemical binding]; other site 471853008537 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 471853008538 ATP Binding subdomain [chemical binding]; other site 471853008539 Ligand Binding sites [chemical binding]; other site 471853008540 Dimerization subdomain; other site 471853008541 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 471853008542 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471853008543 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 471853008544 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853008545 Walker A/P-loop; other site 471853008546 ATP binding site [chemical binding]; other site 471853008547 Q-loop/lid; other site 471853008548 ABC transporter signature motif; other site 471853008549 Walker B; other site 471853008550 D-loop; other site 471853008551 H-loop/switch region; other site 471853008552 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471853008553 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 471853008554 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853008555 Walker A/P-loop; other site 471853008556 ATP binding site [chemical binding]; other site 471853008557 Q-loop/lid; other site 471853008558 ABC transporter signature motif; other site 471853008559 Walker B; other site 471853008560 D-loop; other site 471853008561 H-loop/switch region; other site 471853008562 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 471853008563 active site 471853008564 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 471853008565 putative dimer interface [polypeptide binding]; other site 471853008566 Helix-turn-helix domains; Region: HTH; cl00088 471853008567 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 471853008568 putative phosphoketolase; Provisional; Region: PRK05261 471853008569 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 471853008570 TPP-binding site; other site 471853008571 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 471853008572 XFP C-terminal domain; Region: XFP_C; pfam09363 471853008573 phosphate acetyltransferase; Reviewed; Region: PRK05632 471853008574 DRTGG domain; Region: DRTGG; cl12147 471853008575 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 471853008576 Acetokinase family; Region: Acetate_kinase; cl01029 471853008577 propionate/acetate kinase; Provisional; Region: PRK12379 471853008578 fumarate hydratase; Reviewed; Region: fumC; PRK00485 471853008579 aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596 471853008580 active sites [active] 471853008581 tetramer interface [polypeptide binding]; other site 471853008582 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853008583 Coenzyme A binding pocket [chemical binding]; other site 471853008584 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 471853008585 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 471853008586 active site 471853008587 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 471853008588 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 471853008589 active site 471853008590 substrate binding site [chemical binding]; other site 471853008591 catalytic site [active] 471853008592 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 471853008593 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 471853008594 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 471853008595 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 471853008596 active site 471853008597 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 471853008598 DNA binding residues [nucleotide binding] 471853008599 Transcription factor WhiB; Region: Whib; pfam02467 471853008600 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 471853008601 oligomerisation interface [polypeptide binding]; other site 471853008602 mobile loop; other site 471853008603 roof hairpin; other site 471853008604 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853008605 S-adenosylmethionine binding site [chemical binding]; other site 471853008606 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 471853008607 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 471853008608 Predicted transcriptional regulator [Transcription]; Region: COG2378 471853008609 Helix-turn-helix domains; Region: HTH; cl00088 471853008610 WYL domain; Region: WYL; cl14852 471853008611 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471853008612 active site 471853008613 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853008614 metal binding site [ion binding]; metal-binding site 471853008615 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 471853008616 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853008617 Helix-turn-helix domains; Region: HTH; cl00088 471853008618 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 471853008619 UGMP family protein; Validated; Region: PRK09604 471853008620 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 471853008621 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 471853008622 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 471853008623 active site residue [active] 471853008624 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 471853008625 active site residue [active] 471853008626 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 471853008627 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 471853008628 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 471853008629 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 471853008630 alanine racemase; Reviewed; Region: alr; PRK00053 471853008631 active site 471853008632 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471853008633 dimer interface [polypeptide binding]; other site 471853008634 substrate binding site [chemical binding]; other site 471853008635 catalytic residues [active] 471853008636 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 471853008637 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853008638 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853008639 DNA binding site [nucleotide binding] 471853008640 domain linker motif; other site 471853008641 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 471853008642 putative dimerization interface [polypeptide binding]; other site 471853008643 putative ligand binding site [chemical binding]; other site 471853008644 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 471853008645 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 471853008646 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 471853008647 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 471853008648 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 471853008649 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853008650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853008651 dimer interface [polypeptide binding]; other site 471853008652 conserved gate region; other site 471853008653 ABC-ATPase subunit interface; other site 471853008654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853008655 dimer interface [polypeptide binding]; other site 471853008656 conserved gate region; other site 471853008657 putative PBP binding loops; other site 471853008658 ABC-ATPase subunit interface; other site 471853008659 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 471853008660 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 471853008661 RNHCP domain; Region: RNHCP; pfam12647 471853008662 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 471853008663 active site 471853008664 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 471853008665 nucleotide binding site/active site [active] 471853008666 HIT family signature motif; other site 471853008667 catalytic residue [active] 471853008668 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 471853008669 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471853008670 substrate binding site [chemical binding]; other site 471853008671 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471853008672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853008673 active site 471853008674 phosphorylation site [posttranslational modification] 471853008675 intermolecular recognition site; other site 471853008676 dimerization interface [polypeptide binding]; other site 471853008677 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471853008678 DNA binding site [nucleotide binding] 471853008679 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471853008680 dimer interface [polypeptide binding]; other site 471853008681 phosphorylation site [posttranslational modification] 471853008682 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471853008683 ATP binding site [chemical binding]; other site 471853008684 Mg2+ binding site [ion binding]; other site 471853008685 G-X-G motif; other site 471853008686 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 471853008687 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853008688 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 471853008689 NAD(P) binding site [chemical binding]; other site 471853008690 active site 471853008691 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 471853008692 Ligand binding site; other site 471853008693 Putative Catalytic site; other site 471853008694 DXD motif; other site 471853008695 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471853008696 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853008697 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 471853008698 Moco binding site; other site 471853008699 metal coordination site [ion binding]; other site 471853008700 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471853008701 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 471853008702 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 471853008703 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 471853008704 glutaminase active site [active] 471853008705 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 471853008706 dimer interface [polypeptide binding]; other site 471853008707 active site 471853008708 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 471853008709 dimer interface [polypeptide binding]; other site 471853008710 active site 471853008711 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 471853008712 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471853008713 binding surface 471853008714 TPR motif; other site 471853008715 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 471853008716 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471853008717 TPR motif; other site 471853008718 binding surface 471853008719 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471853008720 Helix-turn-helix domains; Region: HTH; cl00088 471853008721 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 471853008722 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471853008723 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471853008724 pantothenate kinase; Provisional; Region: PRK05439 471853008725 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 471853008726 ATP-binding site [chemical binding]; other site 471853008727 CoA-binding site [chemical binding]; other site 471853008728 Mg2+-binding site [ion binding]; other site 471853008729 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 471853008730 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 471853008731 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 471853008732 active site 471853008733 catalytic residues [active] 471853008734 metal binding site [ion binding]; metal-binding site 471853008735 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 471853008736 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 471853008737 active site 471853008738 substrate binding site [chemical binding]; other site 471853008739 metal binding site [ion binding]; metal-binding site 471853008740 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 471853008741 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 471853008742 23S rRNA interface [nucleotide binding]; other site 471853008743 L3 interface [polypeptide binding]; other site 471853008744 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853008745 short chain dehydrogenase; Provisional; Region: PRK06197 471853008746 NAD(P) binding site [chemical binding]; other site 471853008747 active site 471853008748 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 471853008749 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 471853008750 dimerization interface 3.5A [polypeptide binding]; other site 471853008751 active site 471853008752 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471853008753 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853008754 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 471853008755 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 471853008756 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 471853008757 alphaNTD - beta interaction site [polypeptide binding]; other site 471853008758 alphaNTD homodimer interface [polypeptide binding]; other site 471853008759 alphaNTD - beta' interaction site [polypeptide binding]; other site 471853008760 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 471853008761 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 471853008762 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 471853008763 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 471853008764 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 471853008765 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 471853008766 rRNA binding site [nucleotide binding]; other site 471853008767 predicted 30S ribosome binding site; other site 471853008768 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 471853008769 active site 471853008770 Bacterial sugar transferase; Region: Bac_transf; cl00939 471853008771 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853008772 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 471853008773 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853008774 DNA binding residues [nucleotide binding] 471853008775 dimerization interface [polypeptide binding]; other site 471853008776 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 471853008777 active site 471853008778 adenylate kinase; Reviewed; Region: adk; PRK00279 471853008779 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 471853008780 AMP-binding site [chemical binding]; other site 471853008781 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 471853008782 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 471853008783 SecY translocase; Region: SecY; pfam00344 471853008784 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 471853008785 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 471853008786 23S rRNA binding site [nucleotide binding]; other site 471853008787 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 471853008788 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 471853008789 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 471853008790 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 471853008791 23S rRNA interface [nucleotide binding]; other site 471853008792 5S rRNA interface [nucleotide binding]; other site 471853008793 L27 interface [polypeptide binding]; other site 471853008794 L5 interface [polypeptide binding]; other site 471853008795 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 471853008796 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 471853008797 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 471853008798 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 471853008799 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 471853008800 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 471853008801 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 471853008802 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 471853008803 KOW motif; Region: KOW; cl00354 471853008804 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 471853008805 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 471853008806 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 471853008807 23S rRNA interface [nucleotide binding]; other site 471853008808 putative translocon interaction site; other site 471853008809 signal recognition particle (SRP54) interaction site; other site 471853008810 L23 interface [polypeptide binding]; other site 471853008811 trigger factor interaction site; other site 471853008812 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 471853008813 23S rRNA interface [nucleotide binding]; other site 471853008814 5S rRNA interface [nucleotide binding]; other site 471853008815 putative antibiotic binding site [chemical binding]; other site 471853008816 L25 interface [polypeptide binding]; other site 471853008817 L27 interface [polypeptide binding]; other site 471853008818 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 471853008819 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 471853008820 G-X-X-G motif; other site 471853008821 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 471853008822 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 471853008823 putative translocon binding site; other site 471853008824 protein-rRNA interface [nucleotide binding]; other site 471853008825 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 471853008826 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 471853008827 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 471853008828 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 471853008829 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 471853008830 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 471853008831 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 471853008832 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 471853008833 elongation factor Tu; Reviewed; Region: PRK00049 471853008834 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 471853008835 G1 box; other site 471853008836 GEF interaction site [polypeptide binding]; other site 471853008837 GTP/Mg2+ binding site [chemical binding]; other site 471853008838 Switch I region; other site 471853008839 G2 box; other site 471853008840 G3 box; other site 471853008841 Switch II region; other site 471853008842 G4 box; other site 471853008843 G5 box; other site 471853008844 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 471853008845 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 471853008846 Antibiotic Binding Site [chemical binding]; other site 471853008847 elongation factor G; Reviewed; Region: PRK00007 471853008848 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 471853008849 G1 box; other site 471853008850 putative GEF interaction site [polypeptide binding]; other site 471853008851 GTP/Mg2+ binding site [chemical binding]; other site 471853008852 Switch I region; other site 471853008853 G2 box; other site 471853008854 G3 box; other site 471853008855 Switch II region; other site 471853008856 G4 box; other site 471853008857 G5 box; other site 471853008858 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 471853008859 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 471853008860 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 471853008861 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 471853008862 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 471853008863 S17 interaction site [polypeptide binding]; other site 471853008864 S8 interaction site; other site 471853008865 16S rRNA interaction site [nucleotide binding]; other site 471853008866 streptomycin interaction site [chemical binding]; other site 471853008867 23S rRNA interaction site [nucleotide binding]; other site 471853008868 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 471853008869 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 471853008870 MFS/sugar transport protein; Region: MFS_2; pfam13347 471853008871 YdjC-like protein; Region: YdjC; cl01344 471853008872 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 471853008873 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 471853008874 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 471853008875 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853008876 Walker A/P-loop; other site 471853008877 ATP binding site [chemical binding]; other site 471853008878 Q-loop/lid; other site 471853008879 ABC transporter signature motif; other site 471853008880 Walker B; other site 471853008881 D-loop; other site 471853008882 H-loop/switch region; other site 471853008883 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 471853008884 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 471853008885 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 471853008886 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 471853008887 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 471853008888 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 471853008889 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 471853008890 G-loop; other site 471853008891 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 471853008892 DNA binding site [nucleotide binding] 471853008893 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 471853008894 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 471853008895 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 471853008896 RPB12 interaction site [polypeptide binding]; other site 471853008897 RPB1 interaction site [polypeptide binding]; other site 471853008898 RPB10 interaction site [polypeptide binding]; other site 471853008899 RPB11 interaction site [polypeptide binding]; other site 471853008900 RPB3 interaction site [polypeptide binding]; other site 471853008901 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 471853008902 core dimer interface [polypeptide binding]; other site 471853008903 peripheral dimer interface [polypeptide binding]; other site 471853008904 L10 interface [polypeptide binding]; other site 471853008905 L11 interface [polypeptide binding]; other site 471853008906 putative EF-Tu interaction site [polypeptide binding]; other site 471853008907 putative EF-G interaction site [polypeptide binding]; other site 471853008908 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 471853008909 23S rRNA interface [nucleotide binding]; other site 471853008910 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 471853008911 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 471853008912 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 471853008913 mRNA/rRNA interface [nucleotide binding]; other site 471853008914 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 471853008915 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 471853008916 23S rRNA interface [nucleotide binding]; other site 471853008917 putative thiostrepton binding site; other site 471853008918 L7/L12 interface [polypeptide binding]; other site 471853008919 L25 interface [polypeptide binding]; other site 471853008920 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 471853008921 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 471853008922 putative homodimer interface [polypeptide binding]; other site 471853008923 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 471853008924 aspartate aminotransferase; Provisional; Region: PRK05764 471853008925 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471853008926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853008927 homodimer interface [polypeptide binding]; other site 471853008928 catalytic residue [active] 471853008929 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471853008930 dimerization interface [polypeptide binding]; other site 471853008931 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471853008932 dimer interface [polypeptide binding]; other site 471853008933 phosphorylation site [posttranslational modification] 471853008934 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471853008935 ATP binding site [chemical binding]; other site 471853008936 Mg2+ binding site [ion binding]; other site 471853008937 G-X-G motif; other site 471853008938 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471853008939 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853008940 active site 471853008941 phosphorylation site [posttranslational modification] 471853008942 intermolecular recognition site; other site 471853008943 dimerization interface [polypeptide binding]; other site 471853008944 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471853008945 DNA binding site [nucleotide binding] 471853008946 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 471853008947 active site 471853008948 ATP binding site [chemical binding]; other site 471853008949 substrate binding site [chemical binding]; other site 471853008950 Protein of unknown function (DUF419); Region: DUF419; cl15265 471853008951 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471853008952 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 471853008953 Walker A/P-loop; other site 471853008954 ATP binding site [chemical binding]; other site 471853008955 Q-loop/lid; other site 471853008956 ABC transporter signature motif; other site 471853008957 Walker B; other site 471853008958 D-loop; other site 471853008959 H-loop/switch region; other site 471853008960 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471853008961 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 471853008962 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471853008963 active site 471853008964 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471853008965 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 471853008966 Walker A/P-loop; other site 471853008967 ATP binding site [chemical binding]; other site 471853008968 Q-loop/lid; other site 471853008969 ABC transporter signature motif; other site 471853008970 Walker B; other site 471853008971 D-loop; other site 471853008972 H-loop/switch region; other site 471853008973 Helix-turn-helix domains; Region: HTH; cl00088 471853008974 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 471853008975 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 471853008976 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 471853008977 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853008978 DNA binding site [nucleotide binding] 471853008979 domain linker motif; other site 471853008980 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 471853008981 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 471853008982 active site 2 [active] 471853008983 active site 1 [active] 471853008984 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 471853008985 active site 471853008986 catalytic site [active] 471853008987 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 471853008988 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 471853008989 catalytic Zn binding site [ion binding]; other site 471853008990 structural Zn binding site [ion binding]; other site 471853008991 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853008992 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 471853008993 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 471853008994 motif II; other site 471853008995 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 471853008996 Protein of unknown function (DUF520); Region: DUF520; cl00723 471853008997 Helix-turn-helix domains; Region: HTH; cl00088 471853008998 Peptidase family M48; Region: Peptidase_M48; cl12018 471853008999 ferredoxin-NADP+ reductase; Region: PLN02852 471853009000 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853009001 Predicted permeases [General function prediction only]; Region: RarD; COG2962 471853009002 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 471853009003 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 471853009004 active site 471853009005 catalytic residues [active] 471853009006 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 471853009007 catalytic residues [active] 471853009008 Protein of unknown function (DUF690); Region: DUF690; cl04939 471853009009 Ubiquitin-like proteins; Region: UBQ; cl00155 471853009010 Proteins of 100 residues with WXG; Region: WXG100; cl02005 471853009011 Proteins of 100 residues with WXG; Region: WXG100; cl02005 471853009012 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 471853009013 active site 471853009014 catalytic residues [active] 471853009015 Proteins of 100 residues with WXG; Region: WXG100; cl02005 471853009016 Proteins of 100 residues with WXG; Region: WXG100; cl02005 471853009017 RDD family; Region: RDD; cl00746 471853009018 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 471853009019 phosphopeptide binding site; other site 471853009020 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 471853009021 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853009022 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 471853009023 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853009024 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853009025 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 471853009026 substrate binding pocket [chemical binding]; other site 471853009027 chain length determination region; other site 471853009028 substrate-Mg2+ binding site; other site 471853009029 catalytic residues [active] 471853009030 aspartate-rich region 1; other site 471853009031 active site lid residues [active] 471853009032 aspartate-rich region 2; other site 471853009033 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 471853009034 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 471853009035 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 471853009036 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 471853009037 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 471853009038 NADH dehydrogenase subunit 4; Provisional; Region: ND4; MTH00206 471853009039 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 471853009040 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 471853009041 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 471853009042 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 471853009043 4Fe-4S binding domain; Region: Fer4; cl02805 471853009044 4Fe-4S binding domain; Region: Fer4; cl02805 471853009045 NADH dehydrogenase; Region: NADHdh; cl00469 471853009046 NADH dehydrogenase subunit G; Validated; Region: PRK07860 471853009047 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471853009048 catalytic loop [active] 471853009049 iron binding site [ion binding]; other site 471853009050 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 471853009051 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471853009052 molybdopterin cofactor binding site; other site 471853009053 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 471853009054 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 471853009055 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 471853009056 SLBB domain; Region: SLBB; pfam10531 471853009057 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 471853009058 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 471853009059 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 471853009060 putative dimer interface [polypeptide binding]; other site 471853009061 [2Fe-2S] cluster binding site [ion binding]; other site 471853009062 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 471853009063 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 471853009064 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771 471853009065 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 471853009066 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 471853009067 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853009068 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 471853009069 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 471853009070 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853009071 S-adenosylmethionine binding site [chemical binding]; other site 471853009072 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 471853009073 chorismate binding enzyme; Region: Chorismate_bind; cl10555 471853009074 cell division protein ZipA; Provisional; Region: PRK03427 471853009075 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 471853009076 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 471853009077 protein binding site [polypeptide binding]; other site 471853009078 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 471853009079 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 471853009080 dimer interface [polypeptide binding]; other site 471853009081 tetramer interface [polypeptide binding]; other site 471853009082 PYR/PP interface [polypeptide binding]; other site 471853009083 TPP binding site [chemical binding]; other site 471853009084 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 471853009085 TPP-binding site; other site 471853009086 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 471853009087 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 471853009088 active site 471853009089 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 471853009090 Domain of unknown function DUF21; Region: DUF21; pfam01595 471853009091 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471853009092 Transporter associated domain; Region: CorC_HlyC; cl08393 471853009093 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 471853009094 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 471853009095 tetramer interface [polypeptide binding]; other site 471853009096 heme binding pocket [chemical binding]; other site 471853009097 NADPH binding site [chemical binding]; other site 471853009098 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 471853009099 metal binding site 2 [ion binding]; metal-binding site 471853009100 putative DNA binding helix; other site 471853009101 metal binding site 1 [ion binding]; metal-binding site 471853009102 dimer interface [polypeptide binding]; other site 471853009103 structural Zn2+ binding site [ion binding]; other site 471853009104 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 471853009105 MgtE intracellular N domain; Region: MgtE_N; cl15244 471853009106 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 471853009107 Divalent cation transporter; Region: MgtE; cl00786 471853009108 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 471853009109 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 471853009110 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471853009111 substrate binding site [chemical binding]; other site 471853009112 oxyanion hole (OAH) forming residues; other site 471853009113 trimer interface [polypeptide binding]; other site 471853009114 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 471853009115 AMP-binding enzyme; Region: AMP-binding; cl15778 471853009116 UbiA prenyltransferase family; Region: UbiA; cl00337 471853009117 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 471853009118 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 471853009119 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 471853009120 ResB-like family; Region: ResB; pfam05140 471853009121 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 471853009122 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 471853009123 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 471853009124 catalytic residues [active] 471853009125 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471853009126 catalytic core [active] 471853009127 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 471853009128 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471853009129 Helix-turn-helix domains; Region: HTH; cl00088 471853009130 YceI-like domain; Region: YceI; cl01001 471853009131 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471853009132 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 471853009133 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853009134 motif II; other site 471853009135 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471853009136 non-specific DNA binding site [nucleotide binding]; other site 471853009137 salt bridge; other site 471853009138 sequence-specific DNA binding site [nucleotide binding]; other site 471853009139 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 471853009140 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats with a...; Region: EPT_RTPC-like; cl00288 471853009141 putative active site [active] 471853009142 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 471853009143 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 471853009144 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 471853009145 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471853009146 Domain of unknown function DUF77; Region: DUF77; cl00307 471853009147 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 471853009148 glycosyltransferase, MGT family; Region: MGT; TIGR01426 471853009149 active site 471853009150 TDP-binding site; other site 471853009151 acceptor substrate-binding pocket; other site 471853009152 RNA polymerase factor sigma-70; Validated; Region: PRK08241 471853009153 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853009154 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 471853009155 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853009156 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 471853009157 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 471853009158 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 471853009159 Cation transport protein; Region: TrkH; cl10514 471853009160 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 471853009161 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853009162 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 471853009163 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 471853009164 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853009165 NAD(P) binding site [chemical binding]; other site 471853009166 L-arabinose isomerase; Provisional; Region: PRK02929 471853009167 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 471853009168 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 471853009169 trimer interface [polypeptide binding]; other site 471853009170 putative substrate binding site [chemical binding]; other site 471853009171 putative metal binding site [ion binding]; other site 471853009172 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 471853009173 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 471853009174 intersubunit interface [polypeptide binding]; other site 471853009175 active site 471853009176 Zn2+ binding site [ion binding]; other site 471853009177 ribulokinase; Provisional; Region: PRK04123 471853009178 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 471853009179 N- and C-terminal domain interface [polypeptide binding]; other site 471853009180 active site 471853009181 MgATP binding site [chemical binding]; other site 471853009182 catalytic site [active] 471853009183 metal binding site [ion binding]; metal-binding site 471853009184 carbohydrate binding site [chemical binding]; other site 471853009185 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853009186 DNA binding site [nucleotide binding] 471853009187 lac repressor; Reviewed; Region: lacI; PRK09526 471853009188 domain linker motif; other site 471853009189 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 471853009190 ligand binding site [chemical binding]; other site 471853009191 dimerization interface (open form) [polypeptide binding]; other site 471853009192 dimerization interface (closed form) [polypeptide binding]; other site 471853009193 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 471853009194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853009195 DNA repair protein RadA; Provisional; Region: PRK11823 471853009196 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853009197 Walker A motif; other site 471853009198 ATP binding site [chemical binding]; other site 471853009199 Walker B motif; other site 471853009200 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 471853009201 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 471853009202 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 471853009203 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 471853009204 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 471853009205 minor groove reading motif; other site 471853009206 helix-hairpin-helix signature motif; other site 471853009207 substrate binding pocket [chemical binding]; other site 471853009208 active site 471853009209 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 471853009210 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 471853009211 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853009212 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 471853009213 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471853009214 DNA binding residues [nucleotide binding] 471853009215 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 471853009216 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 471853009217 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 471853009218 amphipathic channel; other site 471853009219 Asn-Pro-Ala signature motifs; other site 471853009220 glycerol kinase; Provisional; Region: glpK; PRK00047 471853009221 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 471853009222 N- and C-terminal domain interface [polypeptide binding]; other site 471853009223 putative active site [active] 471853009224 putative MgATP binding site [chemical binding]; other site 471853009225 catalytic site [active] 471853009226 metal binding site [ion binding]; metal-binding site 471853009227 putative homotetramer interface [polypeptide binding]; other site 471853009228 putative glycerol binding site [chemical binding]; other site 471853009229 homodimer interface [polypeptide binding]; other site 471853009230 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 471853009231 substrate binding site [chemical binding]; other site 471853009232 active site 471853009233 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 471853009234 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 471853009235 phosphate binding site [ion binding]; other site 471853009236 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853009237 active site 471853009238 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 471853009239 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 471853009240 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 471853009241 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 471853009242 Domain of unknown function (DUF385); Region: DUF385; cl04387 471853009243 tetracycline repressor protein TetR; Provisional; Region: PRK13756 471853009244 Helix-turn-helix domains; Region: HTH; cl00088 471853009245 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 471853009246 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 471853009247 Spore germination protein; Region: Spore_permease; cl15802 471853009248 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853009249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853009250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853009251 dimer interface [polypeptide binding]; other site 471853009252 conserved gate region; other site 471853009253 putative PBP binding loops; other site 471853009254 ABC-ATPase subunit interface; other site 471853009255 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853009256 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853009257 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 471853009258 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 471853009259 N- and C-terminal domain interface [polypeptide binding]; other site 471853009260 D-xylulose kinase; Region: XylB; TIGR01312 471853009261 active site 471853009262 MgATP binding site [chemical binding]; other site 471853009263 catalytic site [active] 471853009264 metal binding site [ion binding]; metal-binding site 471853009265 carbohydrate binding site [chemical binding]; other site 471853009266 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 471853009267 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471853009268 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471853009269 short chain dehydrogenase; Validated; Region: PRK07069 471853009270 classical (c) SDRs; Region: SDR_c; cd05233 471853009271 NAD(P) binding site [chemical binding]; other site 471853009272 active site 471853009273 Predicted membrane protein [Function unknown]; Region: COG3428 471853009274 Bacterial PH domain; Region: DUF304; cl01348 471853009275 Bacterial PH domain; Region: DUF304; cl01348 471853009276 Bacterial PH domain; Region: DUF304; cl01348 471853009277 Glucuronate isomerase; Region: UxaC; cl00829 471853009278 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853009279 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853009280 DNA binding site [nucleotide binding] 471853009281 domain linker motif; other site 471853009282 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853009283 dimerization interface [polypeptide binding]; other site 471853009284 ligand binding site [chemical binding]; other site 471853009285 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471853009286 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853009287 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853009288 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 471853009289 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471853009290 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 471853009291 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 471853009292 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 471853009293 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 471853009294 metal binding site [ion binding]; metal-binding site 471853009295 substrate binding pocket [chemical binding]; other site 471853009296 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853009297 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853009298 DNA binding site [nucleotide binding] 471853009299 domain linker motif; other site 471853009300 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 471853009301 putative dimerization interface [polypeptide binding]; other site 471853009302 putative ligand binding site [chemical binding]; other site 471853009303 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 471853009304 Protein of unknown function, DUF624; Region: DUF624; cl02369 471853009305 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 471853009306 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 471853009307 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 471853009308 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 471853009309 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853009310 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853009311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853009312 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853009313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853009314 dimer interface [polypeptide binding]; other site 471853009315 conserved gate region; other site 471853009316 putative PBP binding loops; other site 471853009317 ABC-ATPase subunit interface; other site 471853009318 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 471853009319 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 471853009320 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 471853009321 Fibronectin type III-like domain; Region: Fn3-like; cl15273 471853009322 Helix-turn-helix domains; Region: HTH; cl00088 471853009323 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 471853009324 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 471853009325 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 471853009326 FAD binding pocket [chemical binding]; other site 471853009327 FAD binding motif [chemical binding]; other site 471853009328 phosphate binding motif [ion binding]; other site 471853009329 NAD binding pocket [chemical binding]; other site 471853009330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853009331 putative substrate translocation pore; other site 471853009332 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 471853009333 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853009334 Helix-turn-helix domains; Region: HTH; cl00088 471853009335 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 471853009336 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853009337 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 471853009338 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 471853009339 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 471853009340 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 471853009341 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471853009342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853009343 dimer interface [polypeptide binding]; other site 471853009344 conserved gate region; other site 471853009345 putative PBP binding loops; other site 471853009346 ABC-ATPase subunit interface; other site 471853009347 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 471853009348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853009349 dimer interface [polypeptide binding]; other site 471853009350 conserved gate region; other site 471853009351 putative PBP binding loops; other site 471853009352 ABC-ATPase subunit interface; other site 471853009353 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 471853009354 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471853009355 Walker A/P-loop; other site 471853009356 ATP binding site [chemical binding]; other site 471853009357 Q-loop/lid; other site 471853009358 ABC transporter signature motif; other site 471853009359 Walker B; other site 471853009360 D-loop; other site 471853009361 H-loop/switch region; other site 471853009362 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853009363 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471853009364 Walker A/P-loop; other site 471853009365 ATP binding site [chemical binding]; other site 471853009366 Q-loop/lid; other site 471853009367 ABC transporter signature motif; other site 471853009368 Walker B; other site 471853009369 D-loop; other site 471853009370 H-loop/switch region; other site 471853009371 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853009372 Domain of unknown function (DUF222); Region: DUF222; pfam02720 471853009373 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 471853009374 active site 471853009375 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 471853009376 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 471853009377 inhibitor-cofactor binding pocket; inhibition site 471853009378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853009379 catalytic residue [active] 471853009380 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 471853009381 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 471853009382 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853009383 inhibitor-cofactor binding pocket; inhibition site 471853009384 catalytic residue [active] 471853009385 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853009386 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853009387 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 471853009388 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853009389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853009390 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 471853009391 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471853009392 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853009393 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 471853009394 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 471853009395 inhibitor site; inhibition site 471853009396 active site 471853009397 dimer interface [polypeptide binding]; other site 471853009398 catalytic residue [active] 471853009399 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471853009400 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 471853009401 active site 471853009402 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 471853009403 active site 471853009404 trimer interface [polypeptide binding]; other site 471853009405 allosteric site; other site 471853009406 active site lid [active] 471853009407 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 471853009408 dimerization interface [polypeptide binding]; other site 471853009409 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 471853009410 putative active cleft [active] 471853009411 Sodium:solute symporter family; Region: SSF; cl00456 471853009412 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 471853009413 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853009414 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 471853009415 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853009416 dimerization interface [polypeptide binding]; other site 471853009417 ligand binding site [chemical binding]; other site 471853009418 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 471853009419 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853009420 DNA binding site [nucleotide binding] 471853009421 domain linker motif; other site 471853009422 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853009423 ligand binding site [chemical binding]; other site 471853009424 dimerization interface [polypeptide binding]; other site 471853009425 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 471853009426 Pectate lyase; Region: Pec_lyase_C; cl01593 471853009427 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853009428 G1 box; other site 471853009429 GTP/Mg2+ binding site [chemical binding]; other site 471853009430 G2 box; other site 471853009431 Switch I region; other site 471853009432 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853009433 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853009434 Methane oxygenase PmoA; Region: PmoA; pfam14100 471853009435 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853009436 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853009437 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 471853009438 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853009439 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853009440 Protein of unknown function (DUF993); Region: DUF993; pfam06187 471853009441 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471853009442 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853009443 Predicted ATPase [General function prediction only]; Region: COG3899 471853009444 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471853009445 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853009446 DNA binding residues [nucleotide binding] 471853009447 dimerization interface [polypeptide binding]; other site 471853009448 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 471853009449 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 471853009450 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 471853009451 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 471853009452 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471853009453 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 471853009454 Sodium:solute symporter family; Region: SSF; cl00456 471853009455 Protein of unknown function, DUF485; Region: DUF485; cl01231 471853009456 Sodium:solute symporter family; Region: SSF; cl00456 471853009457 Sodium:solute symporter family; Region: SSF; cl00456 471853009458 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471853009459 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853009460 active site 471853009461 phosphorylation site [posttranslational modification] 471853009462 intermolecular recognition site; other site 471853009463 dimerization interface [polypeptide binding]; other site 471853009464 LytTr DNA-binding domain; Region: LytTR; cl04498 471853009465 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 471853009466 Histidine kinase; Region: His_kinase; pfam06580 471853009467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471853009468 ATP binding site [chemical binding]; other site 471853009469 Mg2+ binding site [ion binding]; other site 471853009470 G-X-G motif; other site 471853009471 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 471853009472 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 471853009473 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 471853009474 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 471853009475 Protein of unknown function (DUF419); Region: DUF419; cl15265 471853009476 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 471853009477 putative active site [active] 471853009478 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853009479 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853009480 DNA binding site [nucleotide binding] 471853009481 domain linker motif; other site 471853009482 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853009483 dimerization interface [polypeptide binding]; other site 471853009484 ligand binding site [chemical binding]; other site 471853009485 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471853009486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853009487 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853009488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853009489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853009490 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853009491 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 471853009492 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cd00036 471853009493 chitin/cellulose binding site [chemical binding]; other site 471853009494 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 471853009495 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 471853009496 sugar binding site [chemical binding]; other site 471853009497 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 471853009498 galactonate dehydratase; Provisional; Region: PRK14017 471853009499 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 471853009500 metal binding site [ion binding]; metal-binding site 471853009501 substrate binding pocket [chemical binding]; other site 471853009502 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 471853009503 active site 471853009504 catalytic triad [active] 471853009505 oxyanion hole [active] 471853009506 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471853009507 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471853009508 active site 471853009509 metal binding site [ion binding]; metal-binding site 471853009510 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853009511 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853009512 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471853009513 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 471853009514 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 471853009515 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853009516 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853009517 DNA binding site [nucleotide binding] 471853009518 domain linker motif; other site 471853009519 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853009520 ligand binding site [chemical binding]; other site 471853009521 dimerization interface [polypeptide binding]; other site 471853009522 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 471853009523 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 471853009524 substrate binding site [chemical binding]; other site 471853009525 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471853009526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853009527 dimer interface [polypeptide binding]; other site 471853009528 conserved gate region; other site 471853009529 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 471853009530 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 471853009531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853009532 dimer interface [polypeptide binding]; other site 471853009533 conserved gate region; other site 471853009534 putative PBP binding loops; other site 471853009535 ABC-ATPase subunit interface; other site 471853009536 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 471853009537 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471853009538 Walker A/P-loop; other site 471853009539 ATP binding site [chemical binding]; other site 471853009540 Q-loop/lid; other site 471853009541 ABC transporter signature motif; other site 471853009542 Walker B; other site 471853009543 D-loop; other site 471853009544 H-loop/switch region; other site 471853009545 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853009546 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471853009547 Walker A/P-loop; other site 471853009548 ATP binding site [chemical binding]; other site 471853009549 Q-loop/lid; other site 471853009550 ABC transporter signature motif; other site 471853009551 Walker B; other site 471853009552 D-loop; other site 471853009553 H-loop/switch region; other site 471853009554 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853009555 Clp protease ATP binding subunit; Region: clpC; CHL00095 471853009556 Clp amino terminal domain; Region: Clp_N; pfam02861 471853009557 Clp amino terminal domain; Region: Clp_N; pfam02861 471853009558 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471853009559 Walker A motif; other site 471853009560 ATP binding site [chemical binding]; other site 471853009561 Walker B motif; other site 471853009562 arginine finger; other site 471853009563 UvrB/uvrC motif; Region: UVR; pfam02151 471853009564 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471853009565 Walker A motif; other site 471853009566 ATP binding site [chemical binding]; other site 471853009567 Walker B motif; other site 471853009568 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 471853009569 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 471853009570 ADP-ribose binding site [chemical binding]; other site 471853009571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853009572 putative substrate translocation pore; other site 471853009573 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 471853009574 Helix-turn-helix domains; Region: HTH; cl00088 471853009575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853009576 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 471853009577 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 471853009578 putative active site [active] 471853009579 dimerization interface [polypeptide binding]; other site 471853009580 putative tRNAtyr binding site [nucleotide binding]; other site 471853009581 L-asparaginase II; Region: Asparaginase_II; cl01842 471853009582 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 471853009583 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 471853009584 putative active site [active] 471853009585 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 471853009586 Predicted membrane protein [Function unknown]; Region: COG4129 471853009587 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 471853009588 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 471853009589 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 471853009590 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 471853009591 heme-binding site [chemical binding]; other site 471853009592 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471853009593 DNA binding site [nucleotide binding] 471853009594 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 471853009595 Phosphate transporter family; Region: PHO4; cl00396 471853009596 Septum formation; Region: Septum_form; pfam13845 471853009597 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 471853009598 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 471853009599 Walker A/P-loop; other site 471853009600 ATP binding site [chemical binding]; other site 471853009601 Q-loop/lid; other site 471853009602 ABC transporter signature motif; other site 471853009603 Walker B; other site 471853009604 D-loop; other site 471853009605 H-loop/switch region; other site 471853009606 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 471853009607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853009608 dimer interface [polypeptide binding]; other site 471853009609 conserved gate region; other site 471853009610 putative PBP binding loops; other site 471853009611 ABC-ATPase subunit interface; other site 471853009612 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853009613 dimer interface [polypeptide binding]; other site 471853009614 conserved gate region; other site 471853009615 putative PBP binding loops; other site 471853009616 ABC-ATPase subunit interface; other site 471853009617 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853009618 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 471853009619 active site 471853009620 Ap6A binding site [chemical binding]; other site 471853009621 nudix motif; other site 471853009622 metal binding site [ion binding]; metal-binding site 471853009623 polyphosphate kinase; Provisional; Region: PRK05443 471853009624 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 471853009625 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 471853009626 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 471853009627 putative domain interface [polypeptide binding]; other site 471853009628 putative active site [active] 471853009629 catalytic site [active] 471853009630 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 471853009631 putative domain interface [polypeptide binding]; other site 471853009632 putative active site [active] 471853009633 catalytic site [active] 471853009634 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 471853009635 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853009636 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853009637 Coenzyme A binding pocket [chemical binding]; other site 471853009638 RNA polymerase sigma factor; Provisional; Region: PRK12537 471853009639 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853009640 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471853009641 DNA binding residues [nucleotide binding] 471853009642 Anti-sigma-K factor rskA; Region: RskA; pfam10099 471853009643 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 471853009644 META domain; Region: META; cl01245 471853009645 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853009646 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 471853009647 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 471853009648 homodimer interface [polypeptide binding]; other site 471853009649 substrate-cofactor binding pocket; other site 471853009650 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853009651 catalytic residue [active] 471853009652 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 471853009653 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853009654 dimer interface [polypeptide binding]; other site 471853009655 conserved gate region; other site 471853009656 putative PBP binding loops; other site 471853009657 ABC-ATPase subunit interface; other site 471853009658 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 471853009659 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 471853009660 substrate binding pocket [chemical binding]; other site 471853009661 membrane-bound complex binding site; other site 471853009662 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 471853009663 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471853009664 Walker A/P-loop; other site 471853009665 ATP binding site [chemical binding]; other site 471853009666 Q-loop/lid; other site 471853009667 ABC transporter signature motif; other site 471853009668 Walker B; other site 471853009669 D-loop; other site 471853009670 H-loop/switch region; other site 471853009671 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 471853009672 H+ Antiporter protein; Region: 2A0121; TIGR00900 471853009673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853009674 putative substrate translocation pore; other site 471853009675 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 471853009676 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 471853009677 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 471853009678 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 471853009679 Right handed beta helix region; Region: Beta_helix; pfam13229 471853009680 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 471853009681 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 471853009682 inhibitor site; inhibition site 471853009683 active site 471853009684 dimer interface [polypeptide binding]; other site 471853009685 catalytic residue [active] 471853009686 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 471853009687 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 471853009688 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471853009689 Walker A/P-loop; other site 471853009690 ATP binding site [chemical binding]; other site 471853009691 Q-loop/lid; other site 471853009692 ABC transporter signature motif; other site 471853009693 Walker B; other site 471853009694 D-loop; other site 471853009695 H-loop/switch region; other site 471853009696 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853009697 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 471853009698 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471853009699 Walker A/P-loop; other site 471853009700 ATP binding site [chemical binding]; other site 471853009701 Q-loop/lid; other site 471853009702 ABC transporter signature motif; other site 471853009703 Walker B; other site 471853009704 D-loop; other site 471853009705 H-loop/switch region; other site 471853009706 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853009707 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 471853009708 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471853009709 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 471853009710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853009711 dimer interface [polypeptide binding]; other site 471853009712 conserved gate region; other site 471853009713 putative PBP binding loops; other site 471853009714 ABC-ATPase subunit interface; other site 471853009715 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471853009716 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853009717 dimer interface [polypeptide binding]; other site 471853009718 conserved gate region; other site 471853009719 ABC-ATPase subunit interface; other site 471853009720 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853009721 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853009722 DNA binding site [nucleotide binding] 471853009723 domain linker motif; other site 471853009724 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853009725 ligand binding site [chemical binding]; other site 471853009726 dimerization interface [polypeptide binding]; other site 471853009727 Domain of unknown function (DUF385); Region: DUF385; cl04387 471853009728 YCII-related domain; Region: YCII; cl00999 471853009729 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 471853009730 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 471853009731 CAAX protease self-immunity; Region: Abi; cl00558 471853009732 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 471853009733 Asp23 family; Region: Asp23; cl00574 471853009734 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471853009735 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853009736 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471853009737 DNA binding residues [nucleotide binding] 471853009738 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471853009739 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853009740 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471853009741 DNA binding residues [nucleotide binding] 471853009742 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 471853009743 active site 471853009744 putative catalytic site [active] 471853009745 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 471853009746 Fasciclin domain; Region: Fasciclin; cl02663 471853009747 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853009748 Pirin-related protein [General function prediction only]; Region: COG1741 471853009749 Cupin domain; Region: Cupin_2; cl09118 471853009750 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 471853009751 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 471853009752 Membrane transport protein; Region: Mem_trans; cl09117 471853009753 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 471853009754 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 471853009755 SelR domain; Region: SelR; pfam01641 471853009756 Uncharacterized conserved protein [Function unknown]; Region: COG2966 471853009757 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 471853009758 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 471853009759 glycerate dehydrogenase; Provisional; Region: PRK06932 471853009760 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853009761 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 471853009762 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853009763 DEAD-like helicases superfamily; Region: DEXDc; smart00487 471853009764 ATP binding site [chemical binding]; other site 471853009765 putative Mg++ binding site [ion binding]; other site 471853009766 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471853009767 nucleotide binding region [chemical binding]; other site 471853009768 ATP-binding site [chemical binding]; other site 471853009769 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 471853009770 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 471853009771 putative NAD(P) binding site [chemical binding]; other site 471853009772 putative active site [active] 471853009773 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 471853009774 UbiA prenyltransferase family; Region: UbiA; cl00337 471853009775 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 471853009776 phytoene desaturase; Region: crtI_fam; TIGR02734 471853009777 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853009778 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 471853009779 substrate binding pocket [chemical binding]; other site 471853009780 substrate-Mg2+ binding site; other site 471853009781 aspartate-rich region 1; other site 471853009782 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 471853009783 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 471853009784 substrate binding site [chemical binding]; other site 471853009785 ATP binding site [chemical binding]; other site 471853009786 Survival protein SurE; Region: SurE; cl00448 471853009787 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 471853009788 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853009789 NAD(P) binding site [chemical binding]; other site 471853009790 active site 471853009791 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 471853009792 Cation efflux family; Region: Cation_efflux; cl00316 471853009793 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853009794 dimerization interface [polypeptide binding]; other site 471853009795 putative DNA binding site [nucleotide binding]; other site 471853009796 putative Zn2+ binding site [ion binding]; other site 471853009797 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 471853009798 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471853009799 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471853009800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853009801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853009802 dimer interface [polypeptide binding]; other site 471853009803 conserved gate region; other site 471853009804 putative PBP binding loops; other site 471853009805 ABC-ATPase subunit interface; other site 471853009806 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 471853009807 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471853009808 Walker A/P-loop; other site 471853009809 ATP binding site [chemical binding]; other site 471853009810 Q-loop/lid; other site 471853009811 ABC transporter signature motif; other site 471853009812 Walker B; other site 471853009813 D-loop; other site 471853009814 H-loop/switch region; other site 471853009815 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 471853009816 Walker A/P-loop; other site 471853009817 ATP binding site [chemical binding]; other site 471853009818 Q-loop/lid; other site 471853009819 ABC transporter signature motif; other site 471853009820 Walker B; other site 471853009821 D-loop; other site 471853009822 H-loop/switch region; other site 471853009823 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853009824 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 471853009825 active site 471853009826 catalytic site [active] 471853009827 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 471853009828 dinuclear metal binding motif [ion binding]; other site 471853009829 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 471853009830 dinuclear metal binding motif [ion binding]; other site 471853009831 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 471853009832 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 471853009833 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 471853009834 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 471853009835 DNA binding residues [nucleotide binding] 471853009836 putative dimer interface [polypeptide binding]; other site 471853009837 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 471853009838 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853009839 active site 471853009840 catalytic tetrad [active] 471853009841 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471853009842 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853009843 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853009844 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 471853009845 NAD(P) binding site [chemical binding]; other site 471853009846 active site 471853009847 5'-3' exonuclease; Region: 53EXOc; smart00475 471853009848 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 471853009849 active site 471853009850 metal binding site 1 [ion binding]; metal-binding site 471853009851 putative 5' ssDNA interaction site; other site 471853009852 metal binding site 3; metal-binding site 471853009853 metal binding site 2 [ion binding]; metal-binding site 471853009854 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 471853009855 putative DNA binding site [nucleotide binding]; other site 471853009856 putative metal binding site [ion binding]; other site 471853009857 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 471853009858 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 471853009859 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 471853009860 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 471853009861 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 471853009862 dimerization interface [polypeptide binding]; other site 471853009863 putative ATP binding site [chemical binding]; other site 471853009864 amidophosphoribosyltransferase; Provisional; Region: PRK07847 471853009865 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 471853009866 active site 471853009867 tetramer interface [polypeptide binding]; other site 471853009868 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471853009869 active site 471853009870 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 471853009871 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471853009872 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 471853009873 Cupin domain; Region: Cupin_2; cl09118 471853009874 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471853009875 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853009876 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 471853009877 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 471853009878 hypothetical protein; Provisional; Region: PRK07877 471853009879 Uncharacterized conserved protein [Function unknown]; Region: COG2128 471853009880 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 471853009881 RNB domain; Region: RNB; pfam00773 471853009882 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 471853009883 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 471853009884 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 471853009885 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853009886 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471853009887 DNA binding residues [nucleotide binding] 471853009888 ribosome small subunit-dependent GTPase A; Region: TIGR00157 471853009889 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 471853009890 GTPase/Zn-binding domain interface [polypeptide binding]; other site 471853009891 GTP/Mg2+ binding site [chemical binding]; other site 471853009892 G4 box; other site 471853009893 G5 box; other site 471853009894 G1 box; other site 471853009895 Switch I region; other site 471853009896 G2 box; other site 471853009897 G3 box; other site 471853009898 Switch II region; other site 471853009899 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 471853009900 Malic enzyme, N-terminal domain; Region: malic; pfam00390 471853009901 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853009902 NAD(P) binding pocket [chemical binding]; other site 471853009903 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 471853009904 Aspartase; Region: Aspartase; cd01357 471853009905 active sites [active] 471853009906 tetramer interface [polypeptide binding]; other site 471853009907 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471853009908 active site 471853009909 ATP binding site [chemical binding]; other site 471853009910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853009911 putative substrate translocation pore; other site 471853009912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853009913 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 471853009914 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853009915 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 471853009916 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 471853009917 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 471853009918 intersubunit interface [polypeptide binding]; other site 471853009919 active site 471853009920 zinc binding site [ion binding]; other site 471853009921 Na+ binding site [ion binding]; other site 471853009922 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 471853009923 putative substrate binding site [chemical binding]; other site 471853009924 putative ATP binding site [chemical binding]; other site 471853009925 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471853009926 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 471853009927 dimer interface [polypeptide binding]; other site 471853009928 active site 471853009929 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 471853009930 dimer interface [polypeptide binding]; other site 471853009931 active site 471853009932 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 471853009933 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853009934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853009935 active site 471853009936 phosphorylation site [posttranslational modification] 471853009937 intermolecular recognition site; other site 471853009938 dimerization interface [polypeptide binding]; other site 471853009939 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853009940 dimerization interface [polypeptide binding]; other site 471853009941 DNA binding residues [nucleotide binding] 471853009942 Histidine kinase; Region: HisKA_3; pfam07730 471853009943 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 471853009944 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471853009945 ATP binding site [chemical binding]; other site 471853009946 Mg2+ binding site [ion binding]; other site 471853009947 G-X-G motif; other site 471853009948 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471853009949 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 471853009950 Walker A/P-loop; other site 471853009951 ATP binding site [chemical binding]; other site 471853009952 Q-loop/lid; other site 471853009953 ABC transporter signature motif; other site 471853009954 Walker B; other site 471853009955 D-loop; other site 471853009956 H-loop/switch region; other site 471853009957 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 471853009958 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 471853009959 dimerization interface [polypeptide binding]; other site 471853009960 ATP binding site [chemical binding]; other site 471853009961 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 471853009962 dimerization interface [polypeptide binding]; other site 471853009963 ATP binding site [chemical binding]; other site 471853009964 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471853009965 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853009966 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 471853009967 Walker A/P-loop; other site 471853009968 ATP binding site [chemical binding]; other site 471853009969 Q-loop/lid; other site 471853009970 ABC transporter signature motif; other site 471853009971 Walker B; other site 471853009972 D-loop; other site 471853009973 H-loop/switch region; other site 471853009974 Helix-turn-helix domains; Region: HTH; cl00088 471853009975 AAA domain; Region: AAA_33; pfam13671 471853009976 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 471853009977 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471853009978 Helix-turn-helix domains; Region: HTH; cl00088 471853009979 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 471853009980 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 471853009981 metal binding site [ion binding]; metal-binding site 471853009982 substrate binding pocket [chemical binding]; other site 471853009983 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853009984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853009985 dimer interface [polypeptide binding]; other site 471853009986 conserved gate region; other site 471853009987 putative PBP binding loops; other site 471853009988 ABC-ATPase subunit interface; other site 471853009989 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853009990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853009991 dimer interface [polypeptide binding]; other site 471853009992 conserved gate region; other site 471853009993 putative PBP binding loops; other site 471853009994 ABC-ATPase subunit interface; other site 471853009995 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853009996 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853009997 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 471853009998 Helix-turn-helix domains; Region: HTH; cl00088 471853009999 DNA-binding site [nucleotide binding]; DNA binding site 471853010000 FCD domain; Region: FCD; cl11656 471853010001 2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505 471853010002 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853010003 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 471853010004 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 471853010005 FAD binding pocket [chemical binding]; other site 471853010006 FAD binding motif [chemical binding]; other site 471853010007 phosphate binding motif [ion binding]; other site 471853010008 NAD binding pocket [chemical binding]; other site 471853010009 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 471853010010 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471853010011 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 471853010012 active site 471853010013 catalytic residues [active] 471853010014 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 471853010015 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 471853010016 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 471853010017 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853010018 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 471853010019 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471853010020 acyl-coenzyme A oxidase; Region: PLN02636 471853010021 active site 471853010022 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853010023 Helix-turn-helix domains; Region: HTH; cl00088 471853010024 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 471853010025 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853010026 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853010027 DNA binding site [nucleotide binding] 471853010028 domain linker motif; other site 471853010029 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853010030 ligand binding site [chemical binding]; other site 471853010031 dimerization interface [polypeptide binding]; other site 471853010032 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 471853010033 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853010034 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 471853010035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010036 dimer interface [polypeptide binding]; other site 471853010037 conserved gate region; other site 471853010038 putative PBP binding loops; other site 471853010039 ABC-ATPase subunit interface; other site 471853010040 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853010041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010042 dimer interface [polypeptide binding]; other site 471853010043 conserved gate region; other site 471853010044 ABC-ATPase subunit interface; other site 471853010045 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 471853010046 Putative glucoamylase; Region: Glycoamylase; pfam10091 471853010047 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 471853010048 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 471853010049 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 471853010050 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 471853010051 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 471853010052 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 471853010053 Fibronectin type III-like domain; Region: Fn3-like; cl15273 471853010054 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 471853010055 cofactor binding site; other site 471853010056 metal binding site [ion binding]; metal-binding site 471853010057 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 471853010058 Helix-turn-helix domains; Region: HTH; cl00088 471853010059 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471853010060 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 471853010061 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 471853010062 Walker A/P-loop; other site 471853010063 ATP binding site [chemical binding]; other site 471853010064 Q-loop/lid; other site 471853010065 ABC transporter signature motif; other site 471853010066 Walker B; other site 471853010067 D-loop; other site 471853010068 H-loop/switch region; other site 471853010069 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471853010070 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 471853010071 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853010072 Walker A/P-loop; other site 471853010073 ATP binding site [chemical binding]; other site 471853010074 Q-loop/lid; other site 471853010075 ABC transporter signature motif; other site 471853010076 Walker B; other site 471853010077 D-loop; other site 471853010078 H-loop/switch region; other site 471853010079 stage V sporulation protein K; Region: spore_V_K; TIGR02881 471853010080 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471853010081 Walker A motif; other site 471853010082 ATP binding site [chemical binding]; other site 471853010083 Walker B motif; other site 471853010084 arginine finger; other site 471853010085 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 471853010086 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471853010087 dimer interface [polypeptide binding]; other site 471853010088 active site 471853010089 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 471853010090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853010091 NAD(P) binding site [chemical binding]; other site 471853010092 active site 471853010093 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 471853010094 active site 2 [active] 471853010095 active site 1 [active] 471853010096 META domain; Region: META; cl01245 471853010097 META domain; Region: META; cl01245 471853010098 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853010099 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 471853010100 Coenzyme A binding pocket [chemical binding]; other site 471853010101 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 471853010102 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853010103 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853010104 Coenzyme A binding pocket [chemical binding]; other site 471853010105 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 471853010106 putative active site [active] 471853010107 catalytic triad [active] 471853010108 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 471853010109 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 471853010110 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 471853010111 ATP binding site [chemical binding]; other site 471853010112 active site 471853010113 substrate binding site [chemical binding]; other site 471853010114 Epoxide hydrolase N terminus; Region: EHN; pfam06441 471853010115 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853010116 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471853010117 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 471853010118 putative NAD(P) binding site [chemical binding]; other site 471853010119 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853010120 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 471853010121 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 471853010122 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471853010123 extended (e) SDRs; Region: SDR_e; cd08946 471853010124 NAD(P) binding site [chemical binding]; other site 471853010125 active site 471853010126 substrate binding site [chemical binding]; other site 471853010127 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 471853010128 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 471853010129 ATP-grasp domain; Region: ATP-grasp_4; cl03087 471853010130 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 471853010131 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 471853010132 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 471853010133 active site 471853010134 substrate-binding site [chemical binding]; other site 471853010135 metal-binding site [ion binding] 471853010136 GTP binding site [chemical binding]; other site 471853010137 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 471853010138 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 471853010139 PQQ-like domain; Region: PQQ_2; pfam13360 471853010140 Protein of unknown function (DUF402); Region: DUF402; cl00979 471853010141 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853010142 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853010143 DNA binding site [nucleotide binding] 471853010144 domain linker motif; other site 471853010145 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853010146 dimerization interface [polypeptide binding]; other site 471853010147 ligand binding site [chemical binding]; other site 471853010148 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 471853010149 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471853010150 DNA binding residues [nucleotide binding] 471853010151 dimer interface [polypeptide binding]; other site 471853010152 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 471853010153 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853010154 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 471853010155 putative dimer interface [polypeptide binding]; other site 471853010156 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853010157 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 471853010158 active site 471853010159 Domain of unknown function (DUF718); Region: DUF718; cl01281 471853010160 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853010161 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853010162 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853010163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010164 dimer interface [polypeptide binding]; other site 471853010165 conserved gate region; other site 471853010166 putative PBP binding loops; other site 471853010167 ABC-ATPase subunit interface; other site 471853010168 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853010169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010170 dimer interface [polypeptide binding]; other site 471853010171 ABC-ATPase subunit interface; other site 471853010172 putative PBP binding loops; other site 471853010173 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 471853010174 hexamer (dimer of trimers) interface [polypeptide binding]; other site 471853010175 substrate binding site [chemical binding]; other site 471853010176 trimer interface [polypeptide binding]; other site 471853010177 Mn binding site [ion binding]; other site 471853010178 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 471853010179 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471853010180 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853010181 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 471853010182 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 471853010183 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853010184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010185 dimer interface [polypeptide binding]; other site 471853010186 conserved gate region; other site 471853010187 putative PBP binding loops; other site 471853010188 ABC-ATPase subunit interface; other site 471853010189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853010190 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853010191 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 471853010192 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 471853010193 short chain dehydrogenase; Validated; Region: PRK08324 471853010194 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 471853010195 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853010196 NAD(P) binding site [chemical binding]; other site 471853010197 active site 471853010198 L-rhamnulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 471853010199 N- and C-terminal domain interface [polypeptide binding]; other site 471853010200 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 471853010201 active site 471853010202 catalytic site [active] 471853010203 metal binding site [ion binding]; metal-binding site 471853010204 ATP binding site [chemical binding]; other site 471853010205 carbohydrate binding site [chemical binding]; other site 471853010206 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 471853010207 active site 471853010208 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471853010209 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 471853010210 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853010211 active site 471853010212 catalytic tetrad [active] 471853010213 Helix-turn-helix domains; Region: HTH; cl00088 471853010214 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 471853010215 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 471853010216 Walker A/P-loop; other site 471853010217 ATP binding site [chemical binding]; other site 471853010218 Q-loop/lid; other site 471853010219 ABC transporter signature motif; other site 471853010220 Walker B; other site 471853010221 D-loop; other site 471853010222 H-loop/switch region; other site 471853010223 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471853010224 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 471853010225 Catalytic site; other site 471853010226 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 471853010227 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 471853010228 GDP-binding site [chemical binding]; other site 471853010229 ACT binding site; other site 471853010230 IMP binding site; other site 471853010231 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 471853010232 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471853010233 anti sigma factor interaction site; other site 471853010234 regulatory phosphorylation site [posttranslational modification]; other site 471853010235 PAS domain; Region: PAS_9; pfam13426 471853010236 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 471853010237 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 471853010238 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 471853010239 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471853010240 anti sigma factor interaction site; other site 471853010241 regulatory phosphorylation site [posttranslational modification]; other site 471853010242 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 471853010243 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 471853010244 active site 471853010245 intersubunit interface [polypeptide binding]; other site 471853010246 zinc binding site [ion binding]; other site 471853010247 Na+ binding site [ion binding]; other site 471853010248 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 471853010249 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471853010250 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 471853010251 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853010252 UMP phosphatase; Provisional; Region: PRK10444 471853010253 active site 471853010254 motif I; other site 471853010255 motif II; other site 471853010256 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853010257 LemA family; Region: LemA; cl00742 471853010258 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 471853010259 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 471853010260 classical (c) SDRs; Region: SDR_c; cd05233 471853010261 NAD(P) binding site [chemical binding]; other site 471853010262 active site 471853010263 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 471853010264 putative phosphate binding site [ion binding]; other site 471853010265 putative catalytic site [active] 471853010266 active site 471853010267 metal binding site A [ion binding]; metal-binding site 471853010268 DNA binding site [nucleotide binding] 471853010269 putative AP binding site [nucleotide binding]; other site 471853010270 putative metal binding site B [ion binding]; other site 471853010271 Septum formation; Region: Septum_form; pfam13845 471853010272 Septum formation; Region: Septum_form; pfam13845 471853010273 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853010274 NAD(P) binding site [chemical binding]; other site 471853010275 active site 471853010276 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853010277 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 471853010278 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471853010279 Walker A motif; other site 471853010280 ATP binding site [chemical binding]; other site 471853010281 Walker B motif; other site 471853010282 arginine finger; other site 471853010283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471853010284 Walker A motif; other site 471853010285 ATP binding site [chemical binding]; other site 471853010286 Walker B motif; other site 471853010287 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 471853010288 Predicted transcriptional regulators [Transcription]; Region: COG1510 471853010289 Helix-turn-helix domains; Region: HTH; cl00088 471853010290 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 471853010291 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471853010292 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596 471853010293 active site 471853010294 Zn binding site [ion binding]; other site 471853010295 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471853010296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010297 dimer interface [polypeptide binding]; other site 471853010298 conserved gate region; other site 471853010299 ABC-ATPase subunit interface; other site 471853010300 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 471853010301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010302 dimer interface [polypeptide binding]; other site 471853010303 conserved gate region; other site 471853010304 putative PBP binding loops; other site 471853010305 ABC-ATPase subunit interface; other site 471853010306 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471853010307 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471853010308 active site 471853010309 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 471853010310 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 471853010311 putative NAD(P) binding site [chemical binding]; other site 471853010312 catalytic Zn binding site [ion binding]; other site 471853010313 structural Zn binding site [ion binding]; other site 471853010314 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471853010315 catalytic core [active] 471853010316 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853010317 S-adenosylmethionine binding site [chemical binding]; other site 471853010318 FAD binding domain; Region: FAD_binding_4; pfam01565 471853010319 Berberine and berberine like; Region: BBE; pfam08031 471853010320 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 471853010321 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853010322 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 471853010323 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 471853010324 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 471853010325 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 471853010326 protein binding site [polypeptide binding]; other site 471853010327 Amidase; Region: Amidase; cl11426 471853010328 RNHCP domain; Region: RNHCP; pfam12647 471853010329 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 471853010330 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471853010331 Helix-turn-helix domains; Region: HTH; cl00088 471853010332 Bacterial transcriptional regulator; Region: IclR; pfam01614 471853010333 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 471853010334 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853010335 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 471853010336 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 471853010337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010338 dimer interface [polypeptide binding]; other site 471853010339 conserved gate region; other site 471853010340 putative PBP binding loops; other site 471853010341 ABC-ATPase subunit interface; other site 471853010342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010343 dimer interface [polypeptide binding]; other site 471853010344 conserved gate region; other site 471853010345 putative PBP binding loops; other site 471853010346 ABC-ATPase subunit interface; other site 471853010347 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 471853010348 putative catalytic site [active] 471853010349 putative metal binding site [ion binding]; other site 471853010350 putative phosphate binding site [ion binding]; other site 471853010351 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 471853010352 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 471853010353 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 471853010354 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 471853010355 Helix-turn-helix domains; Region: HTH; cl00088 471853010356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853010357 putative substrate translocation pore; other site 471853010358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853010359 Cation efflux family; Region: Cation_efflux; cl00316 471853010360 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 471853010361 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 471853010362 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853010363 Walker A/P-loop; other site 471853010364 ATP binding site [chemical binding]; other site 471853010365 Q-loop/lid; other site 471853010366 ABC transporter signature motif; other site 471853010367 Walker B; other site 471853010368 D-loop; other site 471853010369 H-loop/switch region; other site 471853010370 Helix-turn-helix domains; Region: HTH; cl00088 471853010371 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853010372 Helix-turn-helix domains; Region: HTH; cl00088 471853010373 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853010374 dimerization interface [polypeptide binding]; other site 471853010375 putative DNA binding site [nucleotide binding]; other site 471853010376 putative Zn2+ binding site [ion binding]; other site 471853010377 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 471853010378 putative hydrophobic ligand binding site [chemical binding]; other site 471853010379 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 471853010380 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471853010381 Phosphotransferase enzyme family; Region: APH; pfam01636 471853010382 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471853010383 active site 471853010384 ATP binding site [chemical binding]; other site 471853010385 substrate binding site [chemical binding]; other site 471853010386 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471853010387 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 471853010388 putative NAD(P) binding site [chemical binding]; other site 471853010389 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 471853010390 Clp protease; Region: CLP_protease; pfam00574 471853010391 oligomer interface [polypeptide binding]; other site 471853010392 active site residues [active] 471853010393 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 471853010394 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 471853010395 oligomer interface [polypeptide binding]; other site 471853010396 active site residues [active] 471853010397 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 471853010398 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 471853010399 elongation factor G; Reviewed; Region: PRK12740 471853010400 G1 box; other site 471853010401 putative GEF interaction site [polypeptide binding]; other site 471853010402 GTP/Mg2+ binding site [chemical binding]; other site 471853010403 Switch I region; other site 471853010404 G2 box; other site 471853010405 G3 box; other site 471853010406 Switch II region; other site 471853010407 G4 box; other site 471853010408 G5 box; other site 471853010409 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 471853010410 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 471853010411 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 471853010412 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 471853010413 putative hydrophobic ligand binding site [chemical binding]; other site 471853010414 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853010415 dimerization interface [polypeptide binding]; other site 471853010416 putative DNA binding site [nucleotide binding]; other site 471853010417 putative Zn2+ binding site [ion binding]; other site 471853010418 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 471853010419 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 471853010420 catalytic residues [active] 471853010421 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471853010422 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 471853010423 DNA binding residues [nucleotide binding] 471853010424 putative dimer interface [polypeptide binding]; other site 471853010425 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 471853010426 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 471853010427 HSP70 interaction site [polypeptide binding]; other site 471853010428 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 471853010429 substrate binding site [polypeptide binding]; other site 471853010430 dimer interface [polypeptide binding]; other site 471853010431 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 471853010432 dimer interface [polypeptide binding]; other site 471853010433 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 471853010434 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 471853010435 Phosphotransferase enzyme family; Region: APH; pfam01636 471853010436 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471853010437 active site 471853010438 ATP binding site [chemical binding]; other site 471853010439 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471853010440 Helix-turn-helix domains; Region: HTH; cl00088 471853010441 Bacterial transcriptional regulator; Region: IclR; pfam01614 471853010442 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853010443 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853010444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010445 dimer interface [polypeptide binding]; other site 471853010446 conserved gate region; other site 471853010447 putative PBP binding loops; other site 471853010448 ABC-ATPase subunit interface; other site 471853010449 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853010450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010451 dimer interface [polypeptide binding]; other site 471853010452 conserved gate region; other site 471853010453 putative PBP binding loops; other site 471853010454 ABC-ATPase subunit interface; other site 471853010455 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 471853010456 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 471853010457 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 471853010458 active site 471853010459 catalytic residues [active] 471853010460 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471853010461 classical (c) SDRs; Region: SDR_c; cd05233 471853010462 NAD(P) binding site [chemical binding]; other site 471853010463 active site 471853010464 D-mannonate dehydratase (UxuA); Region: UxuA; pfam03786 471853010465 mannonate dehydratase; Region: uxuA; TIGR00695 471853010466 mannonate dehydratase; Region: uxuA; TIGR00695 471853010467 Protein of unknown function (DUF402); Region: DUF402; cl00979 471853010468 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 471853010469 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853010470 S-adenosylmethionine binding site [chemical binding]; other site 471853010471 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 471853010472 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853010473 dimerization interface [polypeptide binding]; other site 471853010474 putative DNA binding site [nucleotide binding]; other site 471853010475 putative Zn2+ binding site [ion binding]; other site 471853010476 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471853010477 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 471853010478 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853010479 Walker A/P-loop; other site 471853010480 ATP binding site [chemical binding]; other site 471853010481 Q-loop/lid; other site 471853010482 ABC transporter signature motif; other site 471853010483 Walker B; other site 471853010484 D-loop; other site 471853010485 H-loop/switch region; other site 471853010486 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 471853010487 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853010488 Q-loop/lid; other site 471853010489 ABC transporter signature motif; other site 471853010490 Walker B; other site 471853010491 D-loop; other site 471853010492 H-loop/switch region; other site 471853010493 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 471853010494 NAD(P) binding site [chemical binding]; other site 471853010495 catalytic residues [active] 471853010496 AAA domain; Region: AAA_33; pfam13671 471853010497 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 471853010498 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 471853010499 DinB superfamily; Region: DinB_2; pfam12867 471853010500 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 471853010501 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 471853010502 active site 471853010503 NTP binding site [chemical binding]; other site 471853010504 metal binding triad [ion binding]; metal-binding site 471853010505 Domain of unknown function (DUF222); Region: DUF222; pfam02720 471853010506 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 471853010507 active site 471853010508 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 471853010509 putative acyl-acceptor binding pocket; other site 471853010510 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 471853010511 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 471853010512 putative dimer interface [polypeptide binding]; other site 471853010513 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471853010514 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471853010515 catalytic residue [active] 471853010516 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 471853010517 TPR repeat; Region: TPR_11; pfam13414 471853010518 Helix-turn-helix domains; Region: HTH; cl00088 471853010519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853010520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853010521 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 471853010522 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471853010523 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 471853010524 coenzyme A binding site [chemical binding]; other site 471853010525 citrylCoA binding site [chemical binding]; other site 471853010526 oxalacetate binding site [chemical binding]; other site 471853010527 catalytic triad [active] 471853010528 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 471853010529 Citrate synthase; Region: Citrate_synt; pfam00285 471853010530 oxalacetate binding site [chemical binding]; other site 471853010531 citrylCoA binding site [chemical binding]; other site 471853010532 coenzyme A binding site [chemical binding]; other site 471853010533 catalytic triad [active] 471853010534 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 471853010535 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853010536 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 471853010537 active site 471853010538 NTP binding site [chemical binding]; other site 471853010539 metal binding triad [ion binding]; metal-binding site 471853010540 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 471853010541 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 471853010542 catalytic residue [active] 471853010543 putative FPP diphosphate binding site; other site 471853010544 putative FPP binding hydrophobic cleft; other site 471853010545 dimer interface [polypeptide binding]; other site 471853010546 putative IPP diphosphate binding site; other site 471853010547 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471853010548 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471853010549 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 471853010550 Walker A/P-loop; other site 471853010551 ATP binding site [chemical binding]; other site 471853010552 Q-loop/lid; other site 471853010553 ABC transporter signature motif; other site 471853010554 Walker B; other site 471853010555 D-loop; other site 471853010556 H-loop/switch region; other site 471853010557 Helix-turn-helix domains; Region: HTH; cl00088 471853010558 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 471853010559 nudix motif; other site 471853010560 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 471853010561 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853010562 Coenzyme A binding pocket [chemical binding]; other site 471853010563 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 471853010564 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 471853010565 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 471853010566 YCII-related domain; Region: YCII; cl00999 471853010567 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 471853010568 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 471853010569 Transcriptional regulators [Transcription]; Region: FadR; COG2186 471853010570 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853010571 DNA-binding site [nucleotide binding]; DNA binding site 471853010572 FCD domain; Region: FCD; cl11656 471853010573 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 471853010574 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 471853010575 putative active site cavity [active] 471853010576 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471853010577 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471853010578 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 471853010579 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 471853010580 inhibitor site; inhibition site 471853010581 active site 471853010582 dimer interface [polypeptide binding]; other site 471853010583 catalytic residue [active] 471853010584 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853010585 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 471853010586 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853010587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010588 dimer interface [polypeptide binding]; other site 471853010589 conserved gate region; other site 471853010590 putative PBP binding loops; other site 471853010591 ABC-ATPase subunit interface; other site 471853010592 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 471853010593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010594 dimer interface [polypeptide binding]; other site 471853010595 conserved gate region; other site 471853010596 putative PBP binding loops; other site 471853010597 ABC-ATPase subunit interface; other site 471853010598 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853010599 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853010600 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853010601 DNA-binding site [nucleotide binding]; DNA binding site 471853010602 FCD domain; Region: FCD; cl11656 471853010603 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 471853010604 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 471853010605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853010606 active site 471853010607 phosphorylation site [posttranslational modification] 471853010608 intermolecular recognition site; other site 471853010609 dimerization interface [polypeptide binding]; other site 471853010610 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471853010611 DNA binding site [nucleotide binding] 471853010612 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 471853010613 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 471853010614 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 471853010615 Ligand Binding Site [chemical binding]; other site 471853010616 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 471853010617 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471853010618 dimer interface [polypeptide binding]; other site 471853010619 phosphorylation site [posttranslational modification] 471853010620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471853010621 K+-transporting ATPase, c chain; Region: KdpC; cl00944 471853010622 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 471853010623 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471853010624 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 471853010625 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 471853010626 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 471853010627 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853010628 Coenzyme A binding pocket [chemical binding]; other site 471853010629 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 471853010630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853010631 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 471853010632 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 471853010633 Walker A/P-loop; other site 471853010634 ATP binding site [chemical binding]; other site 471853010635 Q-loop/lid; other site 471853010636 ABC transporter signature motif; other site 471853010637 Walker B; other site 471853010638 D-loop; other site 471853010639 H-loop/switch region; other site 471853010640 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 471853010641 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471853010642 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853010643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010644 dimer interface [polypeptide binding]; other site 471853010645 conserved gate region; other site 471853010646 putative PBP binding loops; other site 471853010647 ABC-ATPase subunit interface; other site 471853010648 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853010649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010650 putative PBP binding loops; other site 471853010651 dimer interface [polypeptide binding]; other site 471853010652 ABC-ATPase subunit interface; other site 471853010653 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853010654 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853010655 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853010656 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 471853010657 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; cl15424 471853010658 Uncharacterized protein family (UPF0261); Region: UPF0261; cl02262 471853010659 Helix-turn-helix domains; Region: HTH; cl00088 471853010660 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471853010661 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471853010662 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 471853010663 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471853010664 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 471853010665 Walker A/P-loop; other site 471853010666 ATP binding site [chemical binding]; other site 471853010667 Q-loop/lid; other site 471853010668 ABC transporter signature motif; other site 471853010669 Walker B; other site 471853010670 D-loop; other site 471853010671 H-loop/switch region; other site 471853010672 Histidine kinase; Region: HisKA_3; pfam07730 471853010673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471853010674 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853010675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853010676 active site 471853010677 phosphorylation site [posttranslational modification] 471853010678 intermolecular recognition site; other site 471853010679 dimerization interface [polypeptide binding]; other site 471853010680 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853010681 DNA binding residues [nucleotide binding] 471853010682 dimerization interface [polypeptide binding]; other site 471853010683 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 471853010684 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853010685 G1 box; other site 471853010686 GTP/Mg2+ binding site [chemical binding]; other site 471853010687 G2 box; other site 471853010688 Switch I region; other site 471853010689 G3 box; other site 471853010690 Switch II region; other site 471853010691 G4 box; other site 471853010692 G5 box; other site 471853010693 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 471853010694 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 471853010695 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 471853010696 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471853010697 active site 471853010698 ATP binding site [chemical binding]; other site 471853010699 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 471853010700 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853010701 Walker A/P-loop; other site 471853010702 ATP binding site [chemical binding]; other site 471853010703 Q-loop/lid; other site 471853010704 ABC transporter signature motif; other site 471853010705 Walker B; other site 471853010706 D-loop; other site 471853010707 H-loop/switch region; other site 471853010708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010709 ABC-ATPase subunit interface; other site 471853010710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853010711 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853010712 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 471853010713 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 471853010714 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 471853010715 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 471853010716 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 471853010717 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 471853010718 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 471853010719 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 471853010720 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 471853010721 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 471853010722 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 471853010723 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 471853010724 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 471853010725 active site 471853010726 PQQ-like domain; Region: PQQ_2; pfam13360 471853010727 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 471853010728 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 471853010729 trimer interface [polypeptide binding]; other site 471853010730 active site 471853010731 Predicted membrane protein [Function unknown]; Region: COG2364 471853010732 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 471853010733 TIGR02569 family protein; Region: TIGR02569_actnb 471853010734 Domain of unknown function (DUF385); Region: DUF385; cl04387 471853010735 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471853010736 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853010737 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 471853010738 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 471853010739 trimer interface [polypeptide binding]; other site 471853010740 active site 471853010741 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 471853010742 catalytic site [active] 471853010743 short chain dehydrogenase; Provisional; Region: PRK06701 471853010744 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853010745 NAD(P) binding site [chemical binding]; other site 471853010746 active site 471853010747 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 471853010748 Protein of unknown function (DUF419); Region: DUF419; cl15265 471853010749 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 471853010750 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853010751 Coenzyme A binding pocket [chemical binding]; other site 471853010752 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 471853010753 putative acyltransferase; Provisional; Region: PRK05790 471853010754 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471853010755 dimer interface [polypeptide binding]; other site 471853010756 active site 471853010757 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 471853010758 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 471853010759 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 471853010760 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 471853010761 putative active site [active] 471853010762 putative catalytic site [active] 471853010763 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471853010764 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471853010765 active site 471853010766 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 471853010767 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471853010768 ATP-grasp domain; Region: ATP-grasp_4; cl03087 471853010769 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 471853010770 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 471853010771 carboxyltransferase (CT) interaction site; other site 471853010772 biotinylation site [posttranslational modification]; other site 471853010773 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 471853010774 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 471853010775 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 471853010776 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471853010777 E3 interaction surface; other site 471853010778 lipoyl attachment site [posttranslational modification]; other site 471853010779 e3 binding domain; Region: E3_binding; pfam02817 471853010780 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 471853010781 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 471853010782 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 471853010783 tetramer interface [polypeptide binding]; other site 471853010784 TPP-binding site [chemical binding]; other site 471853010785 heterodimer interface [polypeptide binding]; other site 471853010786 phosphorylation loop region [posttranslational modification] 471853010787 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 471853010788 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 471853010789 alpha subunit interface [polypeptide binding]; other site 471853010790 TPP binding site [chemical binding]; other site 471853010791 heterodimer interface [polypeptide binding]; other site 471853010792 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471853010793 Helix-turn-helix domains; Region: HTH; cl00088 471853010794 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853010795 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 471853010796 hypothetical protein; Reviewed; Region: PRK00024 471853010797 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853010798 Uncharacterized conserved protein [Function unknown]; Region: COG2308 471853010799 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl00503 471853010800 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980 471853010801 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 471853010802 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 471853010803 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 471853010804 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471853010805 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 471853010806 active site 471853010807 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 471853010808 active site 471853010809 8-oxo-dGMP binding site [chemical binding]; other site 471853010810 nudix motif; other site 471853010811 metal binding site [ion binding]; metal-binding site 471853010812 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 471853010813 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853010814 putative DNA binding site [nucleotide binding]; other site 471853010815 dimerization interface [polypeptide binding]; other site 471853010816 putative Zn2+ binding site [ion binding]; other site 471853010817 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 471853010818 putative hydrophobic ligand binding site [chemical binding]; other site 471853010819 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 471853010820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853010821 putative substrate translocation pore; other site 471853010822 division inhibitor protein; Provisional; Region: slmA; PRK09480 471853010823 Helix-turn-helix domains; Region: HTH; cl00088 471853010824 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 471853010825 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 471853010826 heme binding pocket [chemical binding]; other site 471853010827 heme ligand [chemical binding]; other site 471853010828 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 471853010829 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853010830 Walker A/P-loop; other site 471853010831 ATP binding site [chemical binding]; other site 471853010832 Q-loop/lid; other site 471853010833 ABC transporter signature motif; other site 471853010834 Walker B; other site 471853010835 D-loop; other site 471853010836 H-loop/switch region; other site 471853010837 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471853010838 dimer interface [polypeptide binding]; other site 471853010839 putative PBP binding regions; other site 471853010840 ABC-ATPase subunit interface; other site 471853010841 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 471853010842 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 471853010843 intersubunit interface [polypeptide binding]; other site 471853010844 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853010845 Helix-turn-helix domains; Region: HTH; cl00088 471853010846 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 471853010847 short chain dehydrogenase; Validated; Region: PRK05855 471853010848 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471853010849 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853010850 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 471853010851 Walker A/P-loop; other site 471853010852 ATP binding site [chemical binding]; other site 471853010853 Q-loop/lid; other site 471853010854 ABC transporter signature motif; other site 471853010855 Walker B; other site 471853010856 D-loop; other site 471853010857 H-loop/switch region; other site 471853010858 Helix-turn-helix domains; Region: HTH; cl00088 471853010859 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 471853010860 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 471853010861 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 471853010862 PA/protease or protease-like domain interface [polypeptide binding]; other site 471853010863 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 471853010864 catalytic residues [active] 471853010865 Predicted transcriptional regulators [Transcription]; Region: COG1378 471853010866 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471853010867 active site 471853010868 substrate binding site [chemical binding]; other site 471853010869 ATP binding site [chemical binding]; other site 471853010870 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853010871 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 471853010872 Walker A/P-loop; other site 471853010873 ATP binding site [chemical binding]; other site 471853010874 Q-loop/lid; other site 471853010875 ABC transporter signature motif; other site 471853010876 Walker B; other site 471853010877 D-loop; other site 471853010878 H-loop/switch region; other site 471853010879 Histidine kinase; Region: HisKA_3; pfam07730 471853010880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471853010881 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853010882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853010883 active site 471853010884 phosphorylation site [posttranslational modification] 471853010885 intermolecular recognition site; other site 471853010886 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853010887 DNA binding residues [nucleotide binding] 471853010888 dimerization interface [polypeptide binding]; other site 471853010889 tetracycline repressor protein TetR; Provisional; Region: PRK13756 471853010890 Helix-turn-helix domains; Region: HTH; cl00088 471853010891 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853010892 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853010893 DNA binding site [nucleotide binding] 471853010894 domain linker motif; other site 471853010895 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853010896 dimerization interface [polypeptide binding]; other site 471853010897 ligand binding site [chemical binding]; other site 471853010898 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853010899 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010900 dimer interface [polypeptide binding]; other site 471853010901 conserved gate region; other site 471853010902 putative PBP binding loops; other site 471853010903 ABC-ATPase subunit interface; other site 471853010904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010905 dimer interface [polypeptide binding]; other site 471853010906 conserved gate region; other site 471853010907 putative PBP binding loops; other site 471853010908 ABC-ATPase subunit interface; other site 471853010909 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853010910 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853010911 Sulfatase; Region: Sulfatase; cl10460 471853010912 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471853010913 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471853010914 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 471853010915 NHL repeat; Region: NHL; pfam01436 471853010916 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 471853010917 active site 471853010918 metal binding site [ion binding]; metal-binding site 471853010919 Helix-turn-helix domains; Region: HTH; cl00088 471853010920 WYL domain; Region: WYL; cl14852 471853010921 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853010922 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 471853010923 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 471853010924 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471853010925 ATP binding site [chemical binding]; other site 471853010926 putative Mg++ binding site [ion binding]; other site 471853010927 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 471853010928 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 471853010929 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853010930 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 471853010931 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 471853010932 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 471853010933 HsdM N-terminal domain; Region: HsdM_N; pfam12161 471853010934 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 471853010935 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853010936 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 471853010937 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 471853010938 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 471853010939 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 471853010940 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471853010941 substrate binding pocket [chemical binding]; other site 471853010942 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853010943 hexokinase; Provisional; Region: PTZ00107 471853010944 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853010945 DNA-binding site [nucleotide binding]; DNA binding site 471853010946 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471853010947 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853010948 homodimer interface [polypeptide binding]; other site 471853010949 catalytic residue [active] 471853010950 Predicted membrane protein [Function unknown]; Region: COG2364 471853010951 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 471853010952 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 471853010953 putative deacylase active site [active] 471853010954 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853010955 putative DNA binding site [nucleotide binding]; other site 471853010956 dimerization interface [polypeptide binding]; other site 471853010957 putative Zn2+ binding site [ion binding]; other site 471853010958 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 471853010959 putative hydrophobic ligand binding site [chemical binding]; other site 471853010960 CLM binding site; other site 471853010961 L1 loop; other site 471853010962 DNA binding site [nucleotide binding] 471853010963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 471853010964 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 471853010965 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 471853010966 Protein of unknown function (DUF805); Region: DUF805; cl01224 471853010967 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 471853010968 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 471853010969 Predicted membrane protein [Function unknown]; Region: COG1470 471853010970 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 471853010971 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 471853010972 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471853010973 Helix-turn-helix domains; Region: HTH; cl00088 471853010974 Bacterial transcriptional regulator; Region: IclR; pfam01614 471853010975 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471853010976 classical (c) SDRs; Region: SDR_c; cd05233 471853010977 NAD(P) binding site [chemical binding]; other site 471853010978 active site 471853010979 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 471853010980 inhibitor site; inhibition site 471853010981 active site 471853010982 dimer interface [polypeptide binding]; other site 471853010983 catalytic residue [active] 471853010984 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853010985 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 471853010986 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010987 dimer interface [polypeptide binding]; other site 471853010988 putative PBP binding loops; other site 471853010989 ABC-ATPase subunit interface; other site 471853010990 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853010991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010992 ABC-ATPase subunit interface; other site 471853010993 putative PBP binding loops; other site 471853010994 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 471853010995 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 471853010996 active site pocket [active] 471853010997 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 471853010998 oxidoreductase; Provisional; Region: PRK12743 471853010999 classical (c) SDRs; Region: SDR_c; cd05233 471853011000 NAD(P) binding site [chemical binding]; other site 471853011001 active site 471853011002 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 471853011003 translocation protein TolB; Provisional; Region: tolB; PRK02889 471853011004 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471853011005 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 471853011006 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471853011007 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 471853011008 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853011009 S-adenosylmethionine binding site [chemical binding]; other site 471853011010 CHRD domain; Region: CHRD; cl06473 471853011011 Copper resistance protein D; Region: CopD; cl00563 471853011012 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 471853011013 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 471853011014 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 471853011015 MoxR-like ATPases [General function prediction only]; Region: COG0714 471853011016 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853011017 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 471853011018 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471853011019 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471853011020 metal ion-dependent adhesion site (MIDAS); other site 471853011021 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 471853011022 metal ion-dependent adhesion site (MIDAS); other site 471853011023 Helix-turn-helix domains; Region: HTH; cl00088 471853011024 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853011025 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471853011026 E3 interaction surface; other site 471853011027 lipoyl attachment site [posttranslational modification]; other site 471853011028 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 471853011029 e3 binding domain; Region: E3_binding; pfam02817 471853011030 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 471853011031 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 471853011032 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 471853011033 alpha subunit interface [polypeptide binding]; other site 471853011034 TPP binding site [chemical binding]; other site 471853011035 heterodimer interface [polypeptide binding]; other site 471853011036 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471853011037 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 471853011038 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 471853011039 TPP-binding site [chemical binding]; other site 471853011040 tetramer interface [polypeptide binding]; other site 471853011041 heterodimer interface [polypeptide binding]; other site 471853011042 phosphorylation loop region [posttranslational modification] 471853011043 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 471853011044 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471853011045 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853011046 homodimer interface [polypeptide binding]; other site 471853011047 catalytic residue [active] 471853011048 Membrane protein of unknown function; Region: DUF360; cl00850 471853011049 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 471853011050 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 471853011051 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471853011052 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 471853011053 nucleoside/Zn binding site; other site 471853011054 dimer interface [polypeptide binding]; other site 471853011055 catalytic motif [active] 471853011056 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 471853011057 putative dimer interface [polypeptide binding]; other site 471853011058 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853011059 adenylosuccinate lyase; Provisional; Region: PRK09285 471853011060 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 471853011061 tetramer interface [polypeptide binding]; other site 471853011062 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471853011063 active site 471853011064 metal binding site [ion binding]; metal-binding site 471853011065 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 471853011066 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471853011067 P-loop; other site 471853011068 Magnesium ion binding site [ion binding]; other site 471853011069 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853011070 DNA-binding site [nucleotide binding]; DNA binding site 471853011071 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853011072 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853011073 dimerization interface [polypeptide binding]; other site 471853011074 ligand binding site [chemical binding]; other site 471853011075 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471853011076 Sulfatase; Region: Sulfatase; cl10460 471853011077 Helix-turn-helix domains; Region: HTH; cl00088 471853011078 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471853011079 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471853011080 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 471853011081 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853011082 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853011083 dimer interface [polypeptide binding]; other site 471853011084 conserved gate region; other site 471853011085 putative PBP binding loops; other site 471853011086 ABC-ATPase subunit interface; other site 471853011087 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853011088 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853011089 dimer interface [polypeptide binding]; other site 471853011090 conserved gate region; other site 471853011091 putative PBP binding loops; other site 471853011092 ABC-ATPase subunit interface; other site 471853011093 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471853011094 Sulfatase; Region: Sulfatase; cl10460 471853011095 PhoD-like phosphatase; Region: PhoD; pfam09423 471853011096 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 471853011097 putative active site [active] 471853011098 putative metal binding site [ion binding]; other site 471853011099 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 471853011100 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853011101 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853011102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853011103 dimer interface [polypeptide binding]; other site 471853011104 conserved gate region; other site 471853011105 putative PBP binding loops; other site 471853011106 ABC-ATPase subunit interface; other site 471853011107 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853011108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853011109 dimer interface [polypeptide binding]; other site 471853011110 conserved gate region; other site 471853011111 putative PBP binding loops; other site 471853011112 ABC-ATPase subunit interface; other site 471853011113 Protein of unknown function (DUF1237); Region: DUF1237; cl15402 471853011114 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 471853011115 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853011116 Coenzyme A binding pocket [chemical binding]; other site 471853011117 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853011118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853011119 dimer interface [polypeptide binding]; other site 471853011120 conserved gate region; other site 471853011121 putative PBP binding loops; other site 471853011122 ABC-ATPase subunit interface; other site 471853011123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853011124 dimer interface [polypeptide binding]; other site 471853011125 conserved gate region; other site 471853011126 putative PBP binding loops; other site 471853011127 ABC-ATPase subunit interface; other site 471853011128 carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein; Region: chitin_NgcE; TIGR03851 471853011129 hypothetical protein; Provisional; Region: PRK02947 471853011130 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 471853011131 putative active site [active] 471853011132 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 471853011133 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 471853011134 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 471853011135 putative active site [active] 471853011136 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 471853011137 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 471853011138 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853011139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853011140 active site 471853011141 phosphorylation site [posttranslational modification] 471853011142 intermolecular recognition site; other site 471853011143 dimerization interface [polypeptide binding]; other site 471853011144 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853011145 DNA binding residues [nucleotide binding] 471853011146 dimerization interface [polypeptide binding]; other site 471853011147 Histidine kinase; Region: HisKA_3; pfam07730 471853011148 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 471853011149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471853011150 multicopper oxidase; Provisional; Region: PRK10965 471853011151 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 471853011152 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 471853011153 Helix-turn-helix domains; Region: HTH; cl00088 471853011154 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853011155 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827 471853011156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853011157 NAD(P) binding pocket [chemical binding]; other site 471853011158 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 471853011159 methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463 471853011160 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 471853011161 substrate binding site [chemical binding]; other site 471853011162 active site 471853011163 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 471853011164 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 471853011165 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 471853011166 domain interfaces; other site 471853011167 active site 471853011168 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 471853011169 active site 471853011170 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cl00338 471853011171 dimer interface [polypeptide binding]; other site 471853011172 active site 471853011173 Schiff base residues; other site 471853011174 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471853011175 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471853011176 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471853011177 catalytic residue [active] 471853011178 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 471853011179 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 471853011180 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 471853011181 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 471853011182 metal-binding site [ion binding] 471853011183 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471853011184 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 471853011185 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 471853011186 metal-binding site [ion binding] 471853011187 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 471853011188 putative homotetramer interface [polypeptide binding]; other site 471853011189 putative homodimer interface [polypeptide binding]; other site 471853011190 putative allosteric switch controlling residues; other site 471853011191 putative metal binding site [ion binding]; other site 471853011192 putative homodimer-homodimer interface [polypeptide binding]; other site 471853011193 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 471853011194 metal-binding site [ion binding] 471853011195 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471853011196 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 471853011197 Walker A/P-loop; other site 471853011198 ATP binding site [chemical binding]; other site 471853011199 Q-loop/lid; other site 471853011200 ABC transporter signature motif; other site 471853011201 Walker B; other site 471853011202 D-loop; other site 471853011203 H-loop/switch region; other site 471853011204 Helix-turn-helix domains; Region: HTH; cl00088 471853011205 CAAX protease self-immunity; Region: Abi; cl00558 471853011206 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 471853011207 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853011208 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 471853011209 CAAX protease self-immunity; Region: Abi; cl00558 471853011210 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 471853011211 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 471853011212 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 471853011213 active site 471853011214 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 471853011215 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471853011216 galactonate dehydratase; Provisional; Region: PRK14017 471853011217 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 471853011218 metal binding site [ion binding]; metal-binding site 471853011219 substrate binding pocket [chemical binding]; other site 471853011220 Carboxylesterase family; Region: COesterase; pfam00135 471853011221 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 471853011222 substrate binding pocket [chemical binding]; other site 471853011223 catalytic triad [active] 471853011224 Transcriptional regulators [Transcription]; Region: FadR; COG2186 471853011225 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853011226 DNA-binding site [nucleotide binding]; DNA binding site 471853011227 FCD domain; Region: FCD; cl11656 471853011228 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 471853011229 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 471853011230 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853011231 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853011232 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853011233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853011234 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853011235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853011236 dimer interface [polypeptide binding]; other site 471853011237 conserved gate region; other site 471853011238 putative PBP binding loops; other site 471853011239 ABC-ATPase subunit interface; other site 471853011240 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853011241 Helix-turn-helix domains; Region: HTH; cl00088 471853011242 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 471853011243 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 471853011244 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 471853011245 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 471853011246 Fibronectin type III-like domain; Region: Fn3-like; cl15273 471853011247 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 471853011248 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853011249 NADH(P)-binding; Region: NAD_binding_10; pfam13460 471853011250 NAD(P) binding site [chemical binding]; other site 471853011251 active site 471853011252 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 471853011253 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 471853011254 active site 471853011255 catalytic site [active] 471853011256 metal binding site [ion binding]; metal-binding site 471853011257 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 471853011258 NMT1-like family; Region: NMT1_2; cl15260 471853011259 CutC family; Region: CutC; cl01218 471853011260 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 471853011261 MlrC C-terminus; Region: MlrC_C; pfam07171 471853011262 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 471853011263 endonuclease III; Region: ENDO3c; smart00478 471853011264 minor groove reading motif; other site 471853011265 helix-hairpin-helix signature motif; other site 471853011266 substrate binding pocket [chemical binding]; other site 471853011267 active site 471853011268 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 471853011269 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 471853011270 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 471853011271 DNA binding site [nucleotide binding] 471853011272 active site 471853011273 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853011274 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 471853011275 Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458 471853011276 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853011277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853011278 dimer interface [polypeptide binding]; other site 471853011279 conserved gate region; other site 471853011280 putative PBP binding loops; other site 471853011281 ABC-ATPase subunit interface; other site 471853011282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853011283 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853011284 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853011285 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853011286 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853011287 Helix-turn-helix domains; Region: HTH; cl00088 471853011288 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853011289 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853011290 dimerization interface [polypeptide binding]; other site 471853011291 ligand binding site [chemical binding]; other site 471853011292 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cl03513 471853011293 substrate binding site [chemical binding]; other site 471853011294 catalytic residues [active] 471853011295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853011296 S-adenosylmethionine binding site [chemical binding]; other site 471853011297 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 471853011298 Helix-turn-helix domains; Region: HTH; cl00088 471853011299 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471853011300 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 471853011301 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 471853011302 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 471853011303 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 471853011304 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 471853011305 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 471853011306 metal binding site [ion binding]; metal-binding site 471853011307 substrate binding pocket [chemical binding]; other site 471853011308 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471853011309 classical (c) SDRs; Region: SDR_c; cd05233 471853011310 NAD(P) binding site [chemical binding]; other site 471853011311 active site 471853011312 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 471853011313 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853011314 active site 471853011315 catalytic tetrad [active] 471853011316 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 471853011317 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853011318 active site 471853011319 catalytic tetrad [active] 471853011320 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 471853011321 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 471853011322 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 471853011323 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 471853011324 YCII-related domain; Region: YCII; cl00999 471853011325 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 471853011326 putative hydrophobic ligand binding site [chemical binding]; other site 471853011327 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471853011328 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 471853011329 Walker A/P-loop; other site 471853011330 ATP binding site [chemical binding]; other site 471853011331 Q-loop/lid; other site 471853011332 ABC transporter signature motif; other site 471853011333 Walker B; other site 471853011334 D-loop; other site 471853011335 H-loop/switch region; other site 471853011336 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853011337 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 471853011338 Walker A/P-loop; other site 471853011339 ATP binding site [chemical binding]; other site 471853011340 Q-loop/lid; other site 471853011341 ABC transporter signature motif; other site 471853011342 Walker B; other site 471853011343 D-loop; other site 471853011344 H-loop/switch region; other site 471853011345 ABC-2 type transporter; Region: ABC2_membrane; cl11417 471853011346 Helix-turn-helix domains; Region: HTH; cl00088 471853011347 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 471853011348 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 471853011349 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853011350 S-adenosylmethionine binding site [chemical binding]; other site 471853011351 YCII-related domain; Region: YCII; cl00999 471853011352 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 471853011353 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853011354 Possible enoyl reductase; Region: MDR_enoyl_red; cd08244 471853011355 putative NAD(P) binding site [chemical binding]; other site 471853011356 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 471853011357 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853011358 NAD(P) binding pocket [chemical binding]; other site 471853011359 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 471853011360 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 471853011361 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 471853011362 HIGH motif; other site 471853011363 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 471853011364 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471853011365 active site 471853011366 KMSKS motif; other site 471853011367 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 471853011368 tRNA binding surface [nucleotide binding]; other site 471853011369 anticodon binding site; other site 471853011370 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 471853011371 Moco binding site; other site 471853011372 metal coordination site [ion binding]; other site 471853011373 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 471853011374 FAD binding pocket [chemical binding]; other site 471853011375 FAD binding motif [chemical binding]; other site 471853011376 phosphate binding motif [ion binding]; other site 471853011377 beta-alpha-beta structure motif; other site 471853011378 NAD binding pocket [chemical binding]; other site 471853011379 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 471853011380 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 471853011381 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 471853011382 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 471853011383 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such...; Region: APH_ChoK_like_1; cd05155 471853011384 putative active site [active] 471853011385 putative substrate binding site [chemical binding]; other site 471853011386 ATP binding site [chemical binding]; other site 471853011387 Protein of unknown function (DUF419); Region: DUF419; cl15265 471853011388 DoxX; Region: DoxX; cl00976 471853011389 H+ Antiporter protein; Region: 2A0121; TIGR00900 471853011390 Helix-turn-helix domains; Region: HTH; cl00088 471853011391 Helix-turn-helix domains; Region: HTH; cl00088 471853011392 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 471853011393 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 471853011394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853011395 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853011396 NAD(P) binding site [chemical binding]; other site 471853011397 active site 471853011398 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471853011399 Sulfatase; Region: Sulfatase; cl10460 471853011400 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 471853011401 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 471853011402 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 471853011403 YCII-related domain; Region: YCII; cl00999 471853011404 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 471853011405 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 471853011406 Interdomain contacts; other site 471853011407 Cytokine receptor motif; other site 471853011408 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 471853011409 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853011410 active site 471853011411 catalytic tetrad [active] 471853011412 Cupin domain; Region: Cupin_2; cl09118 471853011413 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 471853011414 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 471853011415 catalytic Zn binding site [ion binding]; other site 471853011416 NAD(P) binding site [chemical binding]; other site 471853011417 structural Zn binding site [ion binding]; other site 471853011418 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 471853011419 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 471853011420 active site 471853011421 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 471853011422 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788 471853011423 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853011424 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471853011425 active site 471853011426 catalytic tetrad [active] 471853011427 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 471853011428 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 471853011429 YCII-related domain; Region: YCII; cl00999 471853011430 Protein of unknown function (DUF998); Region: DUF998; pfam06197 471853011431 F0F1-type ATP synthase, beta subunit [Energy production and conversion]; Region: AtpD; COG0055 471853011432 Short C-terminal domain; Region: SHOCT; cl01373 471853011433 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 471853011434 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853011435 DNA binding residues [nucleotide binding] 471853011436 dimerization interface [polypeptide binding]; other site 471853011437 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471853011438 Sulfatase; Region: Sulfatase; cl10460 471853011439 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 471853011440 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 471853011441 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471853011442 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853011443 S-adenosylmethionine binding site [chemical binding]; other site 471853011444 tetracycline repressor protein TetR; Provisional; Region: PRK13756 471853011445 Helix-turn-helix domains; Region: HTH; cl00088 471853011446 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 471853011447 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471853011448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 471853011449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853011450 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 471853011451 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 471853011452 hypothetical protein; Validated; Region: PRK07883 471853011453 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 471853011454 GIY-YIG motif/motif A; other site 471853011455 active site 471853011456 catalytic site [active] 471853011457 putative DNA binding site [nucleotide binding]; other site 471853011458 metal binding site [ion binding]; metal-binding site 471853011459 Domain of unknown function (DUF385); Region: DUF385; cl04387 471853011460 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 471853011461 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853011462 motif II; other site 471853011463 DoxX; Region: DoxX; cl00976 471853011464 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 471853011465 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853011466 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 471853011467 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 471853011468 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 471853011469 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 471853011470 amidohydrolase; Region: amidohydrolases; TIGR01891 471853011471 metal binding site [ion binding]; metal-binding site 471853011472 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471853011473 Helix-turn-helix domains; Region: HTH; cl00088 471853011474 Domain of unknown function (DUF385); Region: DUF385; cl04387 471853011475 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 471853011476 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 471853011477 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 471853011478 Family description; Region: UvrD_C_2; cl15862 471853011479 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 471853011480 synthetase active site [active] 471853011481 NTP binding site [chemical binding]; other site 471853011482 metal binding site [ion binding]; metal-binding site 471853011483 Histidine kinase; Region: HisKA_3; pfam07730 471853011484 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 471853011485 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853011486 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853011487 DNA binding residues [nucleotide binding] 471853011488 dimerization interface [polypeptide binding]; other site 471853011489 Helix-turn-helix domains; Region: HTH; cl00088 471853011490 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471853011491 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 471853011492 Walker A/P-loop; other site 471853011493 ATP binding site [chemical binding]; other site 471853011494 Q-loop/lid; other site 471853011495 ABC transporter signature motif; other site 471853011496 Walker B; other site 471853011497 D-loop; other site 471853011498 H-loop/switch region; other site 471853011499 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471853011500 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 471853011501 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853011502 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853011503 dimerization interface [polypeptide binding]; other site 471853011504 putative DNA binding site [nucleotide binding]; other site 471853011505 putative Zn2+ binding site [ion binding]; other site 471853011506 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 471853011507 putative hydrophobic ligand binding site [chemical binding]; other site 471853011508 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 471853011509 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 471853011510 nucleotide binding site [chemical binding]; other site 471853011511 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 471853011512 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 471853011513 Dimer interface [polypeptide binding]; other site 471853011514 anticodon binding site; other site 471853011515 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 471853011516 motif 1; other site 471853011517 dimer interface [polypeptide binding]; other site 471853011518 active site 471853011519 motif 2; other site 471853011520 motif 3; other site 471853011521 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 471853011522 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 471853011523 short chain dehydrogenase; Provisional; Region: PRK06197 471853011524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853011525 NAD(P) binding site [chemical binding]; other site 471853011526 active site 471853011527 replicative DNA helicase; Region: DnaB; TIGR00665 471853011528 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 471853011529 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 471853011530 Walker A motif; other site 471853011531 ATP binding site [chemical binding]; other site 471853011532 Walker B motif; other site 471853011533 DNA binding loops [nucleotide binding] 471853011534 MatE; Region: MatE; cl10513 471853011535 MatE; Region: MatE; cl10513 471853011536 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 471853011537 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 471853011538 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 471853011539 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 471853011540 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 471853011541 dimer interface [polypeptide binding]; other site 471853011542 ssDNA binding site [nucleotide binding]; other site 471853011543 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471853011544 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 471853011545 Transglycosylase; Region: Transgly; cl07896 471853011546 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 471853011547 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 471853011548 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471853011549 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471853011550 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 471853011551 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471853011552 tetrameric interface [polypeptide binding]; other site 471853011553 NAD binding site [chemical binding]; other site 471853011554 catalytic residues [active] 471853011555 classical (c) SDRs; Region: SDR_c; cd05233 471853011556 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 471853011557 NAD(P) binding site [chemical binding]; other site 471853011558 active site 471853011559 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853011560 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853011561 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 471853011562 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471853011563 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 471853011564 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 471853011565 putative NAD(P) binding site [chemical binding]; other site 471853011566 catalytic Zn binding site [ion binding]; other site 471853011567 structural Zn binding site [ion binding]; other site 471853011568 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 471853011569 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471853011570 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 471853011571 substrate binding site [chemical binding]; other site 471853011572 ATP binding site [chemical binding]; other site 471853011573 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 471853011574 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853011575 DNA-binding site [nucleotide binding]; DNA binding site 471853011576 UTRA domain; Region: UTRA; cl01230 471853011577 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853011578 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853011579 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 471853011580 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 471853011581 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471853011582 classical (c) SDRs; Region: SDR_c; cd05233 471853011583 NAD(P) binding site [chemical binding]; other site 471853011584 active site 471853011585 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 471853011586 active site 471853011587 catalytic residues [active] 471853011588 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853011589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853011590 dimer interface [polypeptide binding]; other site 471853011591 conserved gate region; other site 471853011592 putative PBP binding loops; other site 471853011593 ABC-ATPase subunit interface; other site 471853011594 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 471853011595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853011596 dimer interface [polypeptide binding]; other site 471853011597 conserved gate region; other site 471853011598 putative PBP binding loops; other site 471853011599 ABC-ATPase subunit interface; other site 471853011600 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853011601 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853011602 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 471853011603 active site 471853011604 Helix-turn-helix domains; Region: HTH; cl00088 471853011605 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 471853011606 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 471853011607 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 471853011608 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471853011609 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 471853011610 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853011611 motif II; other site 471853011612 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 471853011613 H+ Antiporter protein; Region: 2A0121; TIGR00900 471853011614 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853011615 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 471853011616 Epoxide hydrolase N terminus; Region: EHN; pfam06441 471853011617 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853011618 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 471853011619 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 471853011620 active site 471853011621 NTP binding site [chemical binding]; other site 471853011622 metal binding triad [ion binding]; metal-binding site 471853011623 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 471853011624 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 471853011625 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 471853011626 active site 471853011627 Ap6A binding site [chemical binding]; other site 471853011628 nudix motif; other site 471853011629 metal binding site [ion binding]; metal-binding site 471853011630 MviN-like protein; Region: MVIN; pfam03023 471853011631 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 471853011632 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471853011633 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471853011634 catalytic residues [active] 471853011635 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 471853011636 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471853011637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853011638 homodimer interface [polypeptide binding]; other site 471853011639 catalytic residue [active] 471853011640 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 471853011641 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 471853011642 ATP-grasp domain; Region: ATP-grasp_4; cl03087 471853011643 ParB-like partition proteins; Region: parB_part; TIGR00180 471853011644 ParB-like nuclease domain; Region: ParBc; cl02129 471853011645 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 471853011646 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471853011647 P-loop; other site 471853011648 Magnesium ion binding site [ion binding]; other site 471853011649 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471853011650 Magnesium ion binding site [ion binding]; other site 471853011651 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754 471853011652 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 471853011653 G-X-X-G motif; other site 471853011654 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 471853011655 RxxxH motif; other site 471853011656 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 471853011657 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 471853011658 Haemolytic domain; Region: Haemolytic; cl00506 471853011659 Ribonuclease P; Region: Ribonuclease_P; cl00457 471853011660 Ribosomal protein L34; Region: Ribosomal_L34; cl00370